Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3733

TDMS Study 05123-06 Pathology Tables

NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21

                                                     LUNG TOX CORE ANIMALS




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  1313-99-1

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25026 Other
                               25006 Terminal Sacrifice                25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Exclude 001    0 MG/M3
                               Exclude 002    0 MG/M3
                               Exclude 005    1.25MGM3
                               Exclude 006    1.25MGM3
                               Exclude 010    2.5MG/M3
                               Exclude 013    5.0MG/M3
                               Exclude 014    5.0MG/M3
                               Exclude 009    2.5MG/M3

























Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 7| 0| 0| 0| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 9| 1| 2| 2|                                            |            |
                                           | 6| 9| 0| 0| 3| 2| 2| 1| 4| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |     A      |
    0 MG/M3                                | 8| 8| 8| 9| 9| 0| 0| 2| 3| 5|                                            |     L      |
      LUNGTX                               | 4| 7| 8| 2| 8| 4| 8| 0| 2| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +              +  +  A                                                |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +              +  +  +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +              +  +  +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +              I  +  M                                                |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M              +  M  M                                                |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +              +  +  M                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    M              +  +  +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +              +  +  +                                                |   4        |
      Teratoma Benign                      |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +              +  +  +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +              M  M  M                                                |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +                 +  +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +              M  M  M                                                |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 7| 0| 0| 0| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 9| 1| 2| 2|                                            |            |
                                           | 6| 9| 0| 0| 3| 2| 2| 1| 4| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |     A      |
    0 MG/M3                                | 8| 8| 8| 9| 9| 0| 0| 2| 3| 5|                                            |     L      |
      LUNGTX                               | 4| 7| 8| 2| 8| 4| 8| 0| 2| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M              M  M  M                                                |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +              M  +  +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +              +  +  +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +              +  +  +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +              +  +  +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +              A  +  +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +              +  +  I                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +              +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +              +  +  A                                                |   3        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +              +  +  +                                                |   4        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   3                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 7| 7| 6| 0| 7| 7| 1|                                            |            |
                             DAY ON TEST   | 9| 5| 9| 3| 3| 2| 4| 3| 2| 6|                                            |            |
                                           | 7| 7| 3| 3| 3| 6| 6| 2| 9| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |     A      |
    1.25MGM3                               | 4| 6| 6| 6| 7| 8| 0| 0| 1| 2|                                            |     L      |
      LUNGTX                               | 7| 0| 4| 8| 4| 5| 8| 9| 5| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  A  +        +  A        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  A  +        +  A        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  M  +        +  A        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  A  +        +  A        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +        +  A        +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A  +        +  A        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A  +        +  A        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | A  +  +        +  A        +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A  +  +        +  A        +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +        +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  M        M                                             |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +        +                                             |   6        |
      Pars Distalis, Adenoma               | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +        +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +  +        +                                             |   6        |
      Teratoma Benign                      |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +  +        +                                             |   6        |
      Hemangiosarcoma                      |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   4                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 7| 7| 6| 0| 7| 7| 1|                                            |            |
                             DAY ON TEST   | 9| 5| 9| 3| 3| 2| 4| 3| 2| 6|                                            |            |
                                           | 7| 7| 3| 3| 3| 6| 6| 2| 9| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |     A      |
    1.25MGM3                               | 4| 6| 6| 6| 7| 8| 0| 0| 1| 2|                                            |     L      |
      LUNGTX                               | 7| 0| 4| 8| 4| 5| 8| 9| 5| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Iliac, Lymphoma Malignant            | X                                                                        |          1 |
      Renal, Lymphoma Malignant            | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +        +  +        M                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +        +  +        M                                             |   5        |
      Sarcoma, Metastatic, Skin            |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +  M        +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M        I  M        M                                             |   1        |
      Lymphoma Malignant                   | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +        +  +        +                                             |   6        |
      Lymphoma Malignant                   | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +        +                                                         |   2        |
      Sarcoma                              |       X                                                                  |          1 |
      Pinna, Sarcoma                       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +        +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +        +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +        +                                             |   6        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | A  +  +        +  +        +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +        +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +        +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | A  +  +        +  A        +                                             |   4        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +        +  +        +                                             |   6        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 7| 7| 6| 0| 7| 7| 1|                                            |            |
                             DAY ON TEST   | 9| 5| 9| 3| 3| 2| 4| 3| 2| 6|                                            |            |
                                           | 7| 7| 3| 3| 3| 6| 6| 2| 9| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|                                            |     A      |
    1.25MGM3                               | 4| 6| 6| 6| 7| 8| 0| 0| 1| 2|                                            |     L      |
      LUNGTX                               | 7| 0| 4| 8| 4| 5| 8| 9| 5| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 5| 6| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 3| 7| 3| 3| 3| 3|                                            |            |
                                           | 6| 2| 6| 0| 1| 6| 0| 1| 2| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    2.5MG/M3                               | 1| 1| 1| 3| 4| 4| 5| 5| 6| 7|                                            |     L      |
      LUNGTX                               | 0| 1| 4| 3| 5| 9| 1| 4| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +     +                                                         |   4        |
      Hepatocellular Carcinoma             |       X  X                                                               |          2 |
      Hepatocellular Adenoma               |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  M     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M     +  +     +                                                         |   3        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 5| 6| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 7| 3| 7| 3| 3| 3| 3|                                            |            |
                                           | 6| 2| 6| 0| 1| 6| 0| 1| 2| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    2.5MG/M3                               | 1| 1| 1| 3| 4| 4| 5| 5| 6| 7|                                            |     L      |
      LUNGTX                               | 0| 1| 4| 3| 5| 9| 1| 4| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M     +  M     +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  M     +                                                         |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Nose                                    | A     +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +     +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +     +                                                         |   4        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +     +                                                         |   4        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +  +     +                                                         |   4        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 7| 7| 7| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 4| 6| 3| 3| 3| 9| 9| 5| 3|                                            |            |
                                           | 0| 4| 9| 3| 0| 1| 6| 8| 8| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                                            |     A      |
    5.0MG/M3                               | 8| 9| 9| 9| 0| 0| 1| 2| 2| 2|                                            |     L      |
      LUNGTX                               | 0| 1| 5| 8| 1| 7| 7| 0| 1| 3|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +           +  A  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +           +  A  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    M  +           +  A  +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +           +  A  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +           +  A  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +           +  A  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +           +  A  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +           +  +  +                                                |   5        |
      Hepatocellular Carcinoma             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +           +  +  +                                                |   5        |
      Squamous Cell Papilloma              |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M  +           +  +  M                                                |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +           +  +  +                                                |   5        |
      Follicular Cell, Adenoma             |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                                      |   1        |
      Hemangiosarcoma, Metastatic          |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   9                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 7| 7| 7| 6| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 4| 6| 3| 3| 3| 9| 9| 5| 3|                                            |            |
                                           | 0| 4| 9| 3| 0| 1| 6| 8| 8| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                                            |     A      |
    5.0MG/M3                               | 8| 9| 9| 9| 0| 0| 1| 2| 2| 2|                                            |     L      |
      LUNGTX                               | 0| 1| 5| 8| 1| 7| 7| 0| 1| 3|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +           +  +  +                                                |   5        |
      Hemangiosarcoma, Metastatic          |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    M  +           +  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +           M  +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +           +  +  +                                                |   5        |
      Hemangiosarcoma                      |                   X     X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +           +  +  +                                                |   5        |
      Alveolar/Bronchiolar Carcinoma       |       X           X                                                      |          2 |
      Hepatocellular Carcinoma, Metastatic |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +           +  +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +           +  +  +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +           +  +  +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +           +  +  +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 7| 9| 3| 7| 7| 7| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    O MG/M3                                | 0| 2| 3| 5| 7| 7| 7| 7| 7| 8|                                            |     L      |
      LUNGTX                               | 2| 7| 9| 1| 2| 3| 4| 6| 7| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   1        |
      Hemangiosarcoma                      | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +                                                                  |   2        |
      Hemangiosarcoma, Metastatic          | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  11                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 7| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 7| 9| 3| 7| 7| 7| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    O MG/M3                                | 0| 2| 3| 5| 7| 7| 7| 7| 7| 8|                                            |     L      |
      LUNGTX                               | 2| 7| 9| 1| 2| 3| 4| 6| 7| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +                                                                  |   2        |
      Hemangiosarcoma, Metastatic          | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +                                                                  |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +                                                                  |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  12                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 5| 7| 7| 7| 5| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 5| 0| 1| 3| 3| 6| 3| 2|                                            |            |
                                           | 7| 6| 7| 1| 7| 7| 7| 7| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |     A      |
    1.25MGM3                               | 7| 7| 8| 8| 9| 9| 0| 0| 1| 3|                                            |     L      |
      LUNGTX                               | 0| 2| 2| 5| 4| 8| 8| 9| 3| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    M  +  +  +        +  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    M  +  M  +        M  +  +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    A  +  +  +        +  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +        +  +  +                                             |   7        |
      Hepatocellular Carcinoma             |    X                       X                                             |          2 |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +     +        +  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +     +        +  +  +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +        +  +  +                                             |   7        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  M  +        +  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +        +  +  +                                             |   7        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +  +  +        +  +  +                                             |   7        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |       +     +        +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +  +  +        M  +  +                                             |   6        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +        +  +  +                                             |   7        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 5| 7| 7| 7| 5| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 5| 0| 1| 3| 3| 6| 3| 2|                                            |            |
                                           | 7| 6| 7| 1| 7| 7| 7| 7| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |     A      |
    1.25MGM3                               | 7| 7| 8| 8| 9| 9| 0| 0| 1| 3|                                            |     L      |
      LUNGTX                               | 0| 2| 2| 5| 4| 8| 8| 9| 3| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +        +  +  +                                             |   5        |
      Iliac, Lymphoma Malignant            |          X                                                               |          1 |
      Inguinal, Lymphoma Malignant         |          X                                                               |          1 |
      Renal, Lymphoma Malignant            |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  M  +  +        +  +  +                                             |   6        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +        +  M  +                                             |   6        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +        +  +  +                                             |   7        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M  M  M  M        M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +        +  +  +                                             |   7        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M  +  +  I        +  +  I                                             |   4        |
      Lymphoma Malignant                   |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +        +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +     +        +     +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +        +  +  +                                             |   7        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +        +  +  +                                             |   7        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +  +  I        +  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +        +  +  +                                             |   7        |
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |          1 |
      Hepatocellular Carcinoma, Metastatic |                            X                                             |          1 |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +        +  +  +                                             |   7        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +        +  +  +                                             |   7        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  14                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 5| 7| 7| 7| 5| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 5| 0| 1| 3| 3| 6| 3| 2|                                            |            |
                                           | 7| 6| 7| 1| 7| 7| 7| 7| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                                            |     A      |
    1.25MGM3                               | 7| 7| 8| 8| 9| 9| 0| 0| 1| 3|                                            |     L      |
      LUNGTX                               | 0| 2| 2| 5| 4| 8| 8| 9| 3| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +        +  +  +                                             |   7        |
      Lymphoma Malignant                   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +        +  +  +                                             |   7        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +        +  +  +                                             |   7        |
      Lymphoma Malignant                   |          X                                                               |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  15                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 4| 2| 3| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 3| 3| 8| 4| 6| 3| 7| 3|                                            |            |
                                           | 9| 4| 8| 9| 2| 5| 8| 7| 9| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5MG/M3                               | 2| 3| 4| 6| 6| 7| 7| 7| 8| 9|                                            |     L      |
      LUNGTX                               | 3| 9| 1| 4| 9| 2| 3| 6| 1| 9|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A        +  +  M     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +        +  A  A     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +        +  A  A     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +        +  A  A     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A        +  A  A     +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A        +  A  A     +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A        +  A  A     +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +        +  +  +     +                                                |   6        |
      Hepatocellular Carcinoma, Multiple   |                         X                                                |          1 |
      Hepatocellular Adenoma, Multiple     |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +        +  A  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +        +  A  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +        +  +  +     +                                                |   6        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +        +  M  M     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +        +  +  +     +                                                |   6        |
      Follicular Cell, Adenoma             |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Penis                                   |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +        +  +  +     +                                                |   6        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  16                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 4| 2| 3| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 3| 3| 8| 4| 6| 3| 7| 3|                                            |            |
                                           | 9| 4| 8| 9| 2| 5| 8| 7| 9| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5MG/M3                               | 2| 3| 4| 6| 6| 7| 7| 7| 8| 9|                                            |     L      |
      LUNGTX                               | 3| 9| 1| 4| 9| 2| 3| 6| 1| 9|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +           +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +        +  M  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +        +  M  M     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +        M  M  M     M                                                |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M        +  +  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +        +     +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                       +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +        +  +  +     +                                                |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +        +  +  +     +                                                |   6        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +        +  +  +     +                                                |   6        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +        +  +  +     +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +        +  +  +     +                                                |   6        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +        +  +  +     +                                                |   6        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  17                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 0| 6| 6| 5| 4| 7| 5| 6| 3|                                            |            |
                             DAY ON TEST   | 9| 2| 1| 7| 8| 3| 3| 7| 7| 1|                                            |            |
                                           | 8| 1| 5| 0| 0| 1| 7| 1| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    5.0MG/M3                               | 8| 9| 0| 3| 3| 3| 3| 4| 4| 5|                                            |     L      |
      LUNGTX                               | 2| 9| 7| 1| 2| 4| 5| 1| 5| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  +  +  +     +  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +     M  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +     M  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +     +  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +     +  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +     +  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +  +                                             |   9        |
      Hepatocellular Adenoma               |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +     +  +  M                                             |   8        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +     +  M  M                                             |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                +           +                                             |   2        |
      Sarcoma                              |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Penis                                   | +        +              +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +     +  +  M                                             |   8        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  18                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 0| 6| 6| 5| 4| 7| 5| 6| 3|                                            |            |
                             DAY ON TEST   | 9| 2| 1| 7| 8| 3| 3| 7| 7| 1|                                            |            |
                                           | 8| 1| 5| 0| 0| 1| 7| 1| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    5.0MG/M3                               | 8| 9| 0| 3| 3| 3| 3| 4| 4| 5|                                            |     L      |
      LUNGTX                               | 2| 9| 7| 1| 2| 4| 5| 1| 5| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +     +                                                         |   4        |
      Iliac, Lymphoma Malignant            |       X                                                                  |          1 |
      Inguinal, Lymphoma Malignant         |       X                                                                  |          1 |
      Renal, Lymphoma Malignant            |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +     +  +  M                                             |   7        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M     +  +  +                                             |   8        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +  +                                             |   9        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  M  +  M     +  +  M                                             |   5        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +  +  +                                             |   9        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +     M  M  +                                             |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +              +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +     +  +  +                                             |   9        |
      Alveolar/Bronchiolar Adenoma         |       X  X                                                               |          2 |
      Alveolar/Bronchiolar Carcinoma       |                      X                                                   |          1 |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +     +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  19                                                               
NTP Experiment-Test: 05123-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 04/08/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 0| 6| 6| 5| 4| 7| 5| 6| 3|                                            |            |
                             DAY ON TEST   | 9| 2| 1| 7| 8| 3| 3| 7| 7| 1|                                            |            |
                                           | 8| 1| 5| 0| 0| 1| 7| 1| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    5.0MG/M3                               | 8| 9| 0| 3| 3| 3| 3| 4| 4| 5|                                            |     L      |
      LUNGTX                               | 2| 9| 7| 1| 2| 4| 5| 1| 5| 7|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +     +  +  +                                             |   9        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +                                             |   9        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +     +  +  +                                             |   9        |
      Lymphoma Malignant                   |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  20                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------