TDMS Study 05123-06 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
NICKEL OXIDE
NTP Experiment-Test: 05123-06 Report: PEIRPT05
Study Type: CHRONIC Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 1313-99-1
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/M3 0 MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 20 60 20 60 20
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund Sacrifice 12 3 15 3 6 3
Natural Death 6 1 5 3 10 1
Accidently Killed 1 1
Survivors
Moribund Sacrifice 2
Terminal Sacrifice 40 38 42
Natural Death 1
Terminal Sacrifice 6 4 6
Other 1
Animals Examined Microscopically 60 14 60 16 59 14
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (57) (8) (56) (8) (54) (8)
Intestine Large, Colon (57) (8) (58) (8) (55) (8)
Intestine Large, Rectum (52) (8) (47) (8) (40) (8)
Intestine Large, Cecum (57) (8) (57) (8) (54) (8)
Intestine Small, Duodenum (57) (8) (56) (9) (53) (8)
Intestine Small, Jejunum (56) (8) (56) (8) (53) (8)
Intestine Small, Ileum (55) (8) (54) (8) (53) (8)
Liver (60) (9) (60) (11) (59) (9)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hemangiosarcoma, Metastatic, Uterus 1 (2%)
Hepatocellular Carcinoma 7 (12%) 10 (17%) 6 (10%) 2 (22%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 5 (8%) 7 (12%) 1 (9%) 7 (12%) 1 (11%)
Hepatocellular Adenoma, Multiple 1 (2%)
Hepatocellular Adenoma, Multiple, Multiple 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (2) (2) (1)
Hemangiosarcoma 1 (50%)
Pancreas (60) (9) (60) (11) (58) (9)
Salivary Glands (60) (9) (60) (11) (59) (9)
Stomach, Forestomach (60) (9) (59) (9) (58) (9)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (59) (9) (59) (9) (58) (9)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/M3 0 MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (9) (60) (11) (59) (9)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (9) (60) (11) (59) (9)
Adrenal Medulla (60) (7) (59) (11) (59) (9)
Pheochromocytoma Malignant 2 (3%)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Pituitary Gland (59) (9) (60) (11) (57) (9)
Pars Distalis, Adenoma 6 (10%) 8 (13%) 1 (9%) 8 (14%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (59) (8) (60) (11) (59) (9)
Bilateral, Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Adenoma 2 (3%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (1) (1)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
Fat, Hemangiosarcoma 1 (100%)
Thoracic, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (54) (8) (56) (11) (53) (9)
Duct, Adenoma 1 (2%)
Ovary (57) (9) (60) (11) (57) (8)
Cystadenoma 1 (2%) 3 (5%)
Granulosa-Theca Tumor Benign 1 (2%)
Teratoma Benign 1 (2%) 1 (11%) 1 (9%)
Thecoma Benign 1 (2%)
Uterus (60) (9) (60) (11) (58) (9)
Carcinoma 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 1 (9%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Page 3
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/M3 0 MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Leiomyoma 1 (2%)
Polyp Stromal 2 (3%) 4 (7%)
Sarcoma Stromal 1 (2%) 1 (2%)
Cervix, Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (9) (59) (11) (58) (9)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Lymph Node (15) (8) (1) (9) (1)
Axillary, Hemangiosarcoma 1 (7%) 1 (11%)
Lymph Node, Bronchial (53) (9) (58) (14) (56) (13)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 2 (3%)
Lymph Node, Mandibular (58) (8) (58) (11) (55) (9)
Sarcoma, Metastatic, Skin 1 (9%)
Lymph Node, Mesenteric (53) (6) (58) (10) (51) (8)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Lymph Node, Mediastinal (35) (2) (27) (7) (31) (5)
Alveolar/Bronchiolar Carcinoma, Metastatic 1 (4%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (3%) 1 (4%)
Spleen (60) (9) (60) (12) (59) (9)
Hemangiosarcoma 2 (3%) 2 (3%) 5 (8%)
Thymus (56) (8) (55) (11) (57) (8)
Alveolar/Bronchiolar Carcinoma, Metastatic 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 2 (4%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (9) (60) (11) (59) (9)
Adenoma 1 (2%)
Carcinoma 2 (3%) 3 (5%)
Skin (4) (6) (2) (5) (1)
Hemangiosarcoma 1 (17%)
Melanoma NOS 1 (17%)
Sarcoma 1 (50%) 1 (20%)
Pinna, Sarcoma 1 (50%)
Sebaceous Gland, Adenoma 1 (20%)
Subcutaneous Tissue, Hemangiosarcoma 1 (25%) 1 (17%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/M3 0 MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (9) (59) (11) (59) (9)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Skeletal Muscle (3)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (33%)
Rhabdomyosarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (9) (60) (11) (59) (9)
Carcinoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (58) (9) (57) (11) (58) (9)
Lung (60) (14) (60) (16) (59) (14)
Alveolar/Bronchiolar Adenoma 2 (3%) 2 (3%) 10 (17%) 1 (7%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (3%)
Alveolar/Bronchiolar Carcinoma 4 (7%) 10 (17%) 4 (7%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (6%)
Basosquamous Tumor Malignant, Metastatic, Ear 1 (2%)
Hepatocellular Carcinoma, Metastatic 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (1) (1)
Basosquamous Tumor Malignant 1 (50%)
Fibrosarcoma 1 (100%)
External Ear, Fibrosarcoma 1 (50%)
Harderian Gland (1) (2)
Adenoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (14) (60) (16) (59) (14)
Urinary Bladder (60) (8) (58) (9) (56) (9)
Page 5
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/M3 0 MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(14) *(60) *(16) *(59) *(14)
Histiocytic Sarcoma 2 (3%)
Lymphoma Malignant 13 (22%) 11 (18%) 1 (6%) 9 (15%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/M3 0 MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 36 1 44 6 42 4
Total Primary Neoplasms 67 1 71 8 69 4
Total Animals with Benign Neoplasms 20 1 25 3 27 2
Total Benign Neoplasms 24 1 28 3 37 2
Total Animals with Malignant Neoplasms 30 33 4 26 2
Total Malignant Neoplasms 43 42 5 32 2
Total Animals with Metastatic Neoplasms 5 5 1 3
Total Metastatic Neoplasm 10 10 1 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 20
Scheduled Sacrifice 10
Early Deaths
Moribund Sacrifice 12 4
Natural Death 9 1
Survivors
Terminal Sacrifice 38
Terminal Sacrifice 5
Other 1
Animals Examined Microscopically 59 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (58) (10)
Squamous Cell Carcinoma 1 (2%)
Gallbladder (52) (9)
Sarcoma, Metastatic, Mesentery 1 (2%)
Intestine Large, Colon (53) (9)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Intestine Large, Cecum (52) (9)
Leiomyosarcoma 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Intestine Small, Duodenum (52) (9)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Intestine Small, Ileum (50) (9)
Liver (58) (10)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 3 (5%) 1 (10%)
Hepatocellular Adenoma 5 (9%)
Hepatocholangiocarcinoma 1 (2%)
Histiocytic Sarcoma 2 (3%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Mesentery (2) (1)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (50%)
Sarcoma 1 (50%)
Pancreas (57) (10)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Salivary Glands (58) (10)
Stomach, Forestomach (55) (10)
Sarcoma, Metastatic, Mesentery 1 (2%)
Squamous Cell Papilloma 1 (10%)
Page 8
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Stomach, Glandular (55) (10)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Tooth (2)
Odontoma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (10)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (57) (10)
Adenoma 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Islets, Pancreatic (57) (10)
Pituitary Gland (57) (10)
Pars Distalis, Adenoma 6 (11%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (59) (10)
Follicular Cell, Adenoma 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Hemangiosarcoma, Metastatic 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (58) (10)
Sarcoma, Metastatic, Mesentery 1 (2%)
Teratoma Malignant 1 (2%)
Uterus (58) (11)
Hemangiosarcoma 1 (2%)
Polyp Stromal 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Teratoma Malignant, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (58) (10)
Hemangiosarcoma, Metastatic 1 (10%)
Lymph Node (9)
Pancreatic, Histiocytic Sarcoma 1 (11%)
Pancreatic, Sarcoma, Metastatic, Mesentery 1 (11%)
Renal, Sarcoma, Metastatic, Mesentery 1 (11%)
Lymph Node, Bronchial (57) (15)
Histiocytic Sarcoma 2 (4%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Lymph Node, Mandibular (54) (9)
Lymph Node, Mesenteric (51) (9)
Hemangioma 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Lymph Node, Mediastinal (24) (9)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (4%)
Histiocytic Sarcoma 1 (4%)
Sarcoma, Metastatic, Mesentery 1 (4%)
Spleen (58) (10)
Hemangiosarcoma 2 (20%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 2 (3%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Thymus (52) (9)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (10)
Carcinoma 3 (5%)
Skin (11) (2)
Sarcoma 1 (9%)
Squamous Cell Papilloma 1 (9%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (3)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (33%)
Sarcoma, Metastatic, Mesentery 1 (33%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (10)
Hypothalamus, Carcinoma, Metastatic 1 (2%)
Pons, Carcinoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (15)
Alveolar/Bronchiolar Adenoma 3 (5%)
Alveolar/Bronchiolar Carcinoma 3 (5%) 2 (13%)
Hepatocellular Carcinoma, Metastatic 1 (7%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 2 (3%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Teratoma Malignant, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3)
Adenoma 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (15)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Teratoma Malignant, Metastatic 1 (2%)
Urinary Bladder (52) (10)
Sarcoma, Metastatic, Mesentery 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(59) *(15)
Histiocytic Sarcoma 2 (3%)
Lymphoma Malignant 7 (12%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 36 4
Total Primary Neoplasms 50 7
Total Animals with Benign Neoplasms 22 2
Total Benign Neoplasms 23 2
Total Animals with Malignant Neoplasms 24 4
Total Malignant Neoplasms 27 5
Total Animals with Metastatic Neoplasms 4 2
Total Metastatic Neoplasm 37 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/M3 O MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 20 60 20 60 20
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund Sacrifice 22 1 20 6 23 3
Natural Death 14 1 17 1 8 3
Accidently Killed 4 6
Survivors
Terminal Sacrifice 19 23 29
Terminal Sacrifice 2 3 4
Other 1
Animals Examined Microscopically 55 12 60 17 60 16
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (54) (7) (60) (12) (60) (11)
Squamous Cell Carcinoma 1 (2%)
Intestine Small, Duodenum (49) (7) (46) (12) (53) (8)
Adenoma 1 (2%)
Intestine Small, Ileum (49) (7) (43) (11) (52) (8)
Liver (55) (8) (60) (12) (60) (13)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatocellular Carcinoma 6 (11%) 1 (13%) 11 (18%) 3 (25%) 8 (13%) 1 (8%)
Hepatocellular Carcinoma, Multiple 3 (5%) 2 (3%) 1 (8%)
Hepatocellular Adenoma 7 (13%) 2 (25%) 5 (8%) 1 (8%) 11 (18%) 4 (31%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (2%) 1 (8%)
Mesentery (1) (1)
Lipoma 1 (100%)
Salivary Glands (55) (7) (60) (12) (60) (11)
Stomach, Forestomach (52) (7) (57) (11) (60) (10)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Tooth (2) (5) (4)
Odontoma 1 (20%) 2 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (55) (7) (60) (12) (60) (11)
____________________________________________________________________________________________________________________________________
Page 13
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/M3 O MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (55) (7) (60) (12) (59) (11)
Adenoma 2 (4%)
Capsule, Adenoma 2 (4%) 1 (2%)
Islets, Pancreatic (52) (7) (57) (12) (60) (11)
Adenoma 1 (2%)
Thyroid Gland (53) (7) (60) (12) (60) (11)
Bilateral, Follicular Cell, Adenoma 2 (3%)
Follicular Cell, Adenoma 2 (4%) 1 (14%) 1 (2%) 1 (9%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (1) (3)
Hemangiosarcoma 1 (100%)
Lipoma 1 (33%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (54) (7) (60) (12) (60) (11)
Sarcoma 1 (2%)
Prostate (51) (7) (55) (11) (57) (11)
Testes (55) (7) (59) (12) (60) (11)
Interstitial Cell, Adenoma 2 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (54) (7) (59) (12) (60) (11)
Hemangiosarcoma, Metastatic 1 (14%)
Lymph Node (21) (2) (13) (6) (17) (3)
Lymph Node, Bronchial (43) (11) (50) (14) (56) (15)
Lymph Node, Mandibular (45) (7) (51) (11) (57) (11)
Lymph Node, Mesenteric (43) (7) (48) (12) (52) (9)
Lymph Node, Mediastinal (16) (8) (19) (2) (19) (8)
Hemangiosarcoma, Metastatic 1 (5%)
Spleen (54) (7) (60) (12) (60) (11)
Hemangiosarcoma 1 (2%) 1 (2%) 2 (3%)
Thymus (43) (7) (49) (8) (47) (10)
____________________________________________________________________________________________________________________________________
Page 14
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/M3 O MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (16) (18) (5) (22) (2)
Hamartoma 1 (6%)
Subcutaneous Tissue, Hemangioma 1 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (55) (7) (60) (12) (60) (11)
Hemangiosarcoma, Metastatic 1 (14%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (55) (12) (60) (17) (60) (16)
Alveolar/Bronchiolar Adenoma 7 (13%) 2 (17%) 5 (8%) 6 (10%)
Alveolar/Bronchiolar Carcinoma 4 (7%) 8 (13%) 1 (6%) 9 (15%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Hepatocellular Carcinoma, Metastatic 1 (8%) 1 (6%) 3 (5%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Nose (53) (12) (59) (17) (60) (16)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (2)
Adenoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (55) (12) (60) (17) (60) (16)
Urinary Bladder (52) (7) (56) (12) (59) (10)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(55) *(12) *(60) *(17) *(60) *(16)
Lymphoma Malignant 2 (4%) 1 (2%) 1 (6%) 2 (3%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 15
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/M3 O MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 28 6 33 6 38 7
Total Primary Neoplasms 38 7 45 6 52 8
Total Animals with Benign Neoplasms 18 4 16 1 23 6
Total Benign Neoplasms 23 5 18 1 29 6
Total Animals with Malignant Neoplasms 14 2 24 5 21 2
Total Malignant Neoplasms 15 2 27 5 23 2
Total Animals with Metastatic Neoplasms 2 1 1 4
Total Metastatic Neoplasm 3 1 1 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 16
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 20
Scheduled Sacrifice 10
Early Deaths
Moribund Sacrifice 22 7
Natural Death 15 2
Survivors
Terminal Sacrifice 23
Terminal Sacrifice 1
Animals Examined Microscopically 60 19
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (53) (14)
Intestine Large, Cecum (52) (13)
Intestine Small, Ileum (49) (13)
Liver (60) (14)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hemangiosarcoma 2 (3%)
Hepatocellular Carcinoma 13 (22%)
Hepatocellular Carcinoma, Multiple 2 (3%)
Hepatocellular Adenoma 8 (13%) 1 (7%)
Hepatocholangiocarcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Stomach, Forestomach (58) (14)
Squamous Cell Papilloma 1 (2%)
Tooth (1)
Odontoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (14)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
Page 17
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (14)
Adenoma 1 (2%)
Thyroid Gland (60) (14)
Follicular Cell, Adenoma 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (2)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (50%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (50%)
Sarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (12) (4)
Axillary, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (8%)
Lymph Node, Bronchial (55) (16)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Lymph Node, Mandibular (52) (13)
Lymph Node, Mesenteric (54) (14)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Lymph Node, Mediastinal (20) (9)
Spleen (60) (14)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (51) (12)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 18
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (19)
Alveolar/Bronchiolar Adenoma 9 (15%) 2 (11%)
Alveolar/Bronchiolar Carcinoma 4 (7%) 1 (5%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Hepatocellular Carcinoma, Metastatic 4 (7%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3)
Adenoma 2 (67%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (19)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(19)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant 4 (7%) 1 (5%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 19
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 39 5
Total Primary Neoplasms 54 6
Total Animals with Benign Neoplasms 23 3
Total Benign Neoplasms 25 3
Total Animals with Malignant Neoplasms 27 3
Total Malignant Neoplasms 29 3
Total Animals with Metastatic Neoplasms 6
Total Metastatic Neoplasm 15
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 20
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