TDMS Study 05123-06 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
NICKEL OXIDE
NTP Experiment-Test: 05123-06 Report: PEIRPT09
Study Type: CHRONIC Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
2 YEAR CORE STUDY
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 1313-99-1
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25026 Other
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Merge 002 002,004 0 MG/M3
Merge 006 006,008 1.25MGM3
Merge 010 010,012 2.5MG/M3
Merge 014 014,016 5.0MG/M3
Merge 001 001,003 0 MG/M3
Merge 005 005,007 1.25MGM3
Merge 009 009,011 2.5MG/M3
Merge 013 013,015 5.0MG/M3
Page 1
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 5| 7| 5| 1| 2| 7| 6| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 1| 0| 0| 6| 3| 7| 7|
DAY ON TEST | 1| 3| 9| 1| 2| 2| 3| 3| 3| 3| 1| 2| 3| 2| 9| 3| 3| 3| 3| 2| 9| 4| 5| 3| 3|
| 0| 0| 9| 7| 9| 9| 8| 2| 0| 6| 4| 8| 0| 9| 5| 0| 3| 2| 2| 9| 2| 2| 7| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 2| 3| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + M + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Basophilic Focus | X |
Clear Cell Focus | |
Eosinophilic Focus | |
Inflammation, Chronic, Focal | |
Inflammation, Chronic | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 3 |
Spindle Cell, Hyperplasia | 3 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + I + + + +|
Degeneration | |
Hyperplasia | |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M M + + + + M + + M + + M + M + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 5| 7| 5| 1| 2| 7| 6| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 1| 0| 0| 6| 3| 7| 7|
DAY ON TEST | 1| 3| 9| 1| 2| 2| 3| 3| 3| 3| 1| 2| 3| 2| 9| 3| 3| 3| 3| 2| 9| 4| 5| 3| 3|
| 0| 0| 9| 7| 9| 9| 8| 2| 0| 6| 4| 8| 0| 9| 5| 0| 3| 2| 2| 9| 2| 2| 7| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 2| 3| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Angiectasis | 1 2 |
Pars Distalis, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 1 2 2 3 2 3 2|
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + M + + M + I + + I + + M + + + + + +|
Ectasia | |
Inflammation, Chronic | |
Pigmentation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + I +|
Abscess | |
Cyst | X X X X|
Inflammation, Suppurative | |
Rete Ovarii, Thrombosis | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 3 4 1 3 3 3 2 1 3 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
Myeloid Cell, Hyperplasia | 4 2 |
__________________________________________________________________________|
Lymph Node | + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + I I + + + + + + M + + + + + + + M + M + M + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | 2 4 2 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + M A M + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M M + + + M M M + + + + + + + M M M M M + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + M + M + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 5| 7| 5| 1| 2| 7| 6| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 1| 0| 0| 6| 3| 7| 7|
DAY ON TEST | 1| 3| 9| 1| 2| 2| 3| 3| 3| 3| 1| 2| 3| 2| 9| 3| 3| 3| 3| 2| 9| 4| 5| 3| 3|
| 0| 0| 9| 7| 9| 9| 8| 2| 0| 6| 4| 8| 0| 9| 5| 0| 3| 2| 2| 9| 2| 2| 7| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 2| 3| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | |
__________________________________________________________________________|
Skin | + +|
Inflammation, Chronic Active | |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
Hyperostosis | 1 1 1 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 2 |
Pigmentation, Hemosiderin | 1 2 |
Alveolus, Hyperplasia, Macrophage | 3 |
__________________________________________________________________________|
Nose | + + + A + + + + + + + + + + + + + + + + A + + + +|
Capillary, Thrombosis | 4 |
Olfactory Epithelium, Degeneration | 1 1 2 1 |
Respiratory Epithelium, Degeneration | 2 1 1 1 2 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Inflammation,| |
Suppurative | 3 1 1 1 2 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Metaplasia, Osseous | 1 |
Nephropathy | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 5| 7| 5| 1| 2| 7| 6| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 1| 0| 0| 6| 3| 7| 7|
DAY ON TEST | 1| 3| 9| 1| 2| 2| 3| 3| 3| 3| 1| 2| 3| 2| 9| 3| 3| 3| 3| 2| 9| 4| 5| 3| 3|
| 0| 0| 9| 7| 9| 9| 8| 2| 0| 6| 4| 8| 0| 9| 5| 0| 3| 2| 2| 9| 2| 2| 7| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 2| 3| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Glomerulus, Thrombosis | 2 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 3| 3| 3| 1| 3| 3| 3| 3| 2| 8| 3| 3| 3| 2| 1| 3| 3| 9| 8| 3| 3| 2|
| 8| 9| 9| 6| 2| 2| 1| 1| 0| 3| 3| 9| 6| 2| 2| 2| 4| 8| 1| 0| 4| 8| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A M + M + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A A + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + M + + + A A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Basophilic Focus | |
Clear Cell Focus | X X |
Eosinophilic Focus | X X |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | |
Hepatocyte, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tooth | + +|
Developmental Malformation | X |
Inflammation | 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Vacuolization Cytoplasmic | |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
Degeneration | 3 |
Hyperplasia | 2 |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M I + + + M + + + + + + + + + M + + + I + + + M|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 3| 3| 3| 1| 3| 3| 3| 3| 2| 8| 3| 3| 3| 2| 1| 3| 3| 9| 8| 3| 3| 2|
| 8| 9| 9| 6| 2| 2| 1| 1| 0| 3| 3| 9| 6| 2| 2| 2| 4| 8| 1| 0| 4| 8| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 4 4 4|
Pars Distalis, Hyperplasia | 4 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Cystic | 1 1 1 4 2 1 2 1 3 1 |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Inflammation, Chronic | 4 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + M +|
Abscess | 4 |
Cyst | X X |
Inflammation, Suppurative | 3 |
Rete Ovarii, Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 1 3 4 1 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Hyperplasia, Lymphoid | 4 |
Renal, Hyperplasia, Lymphoid | 4 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + + + + + + + + M + + + + + + + I|
Hyperplasia, Lymphoid | 2 1 2 2 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia, Lymphoid | 2 3 4 3 2 3 1|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + M M + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 3 2 2 1|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M M M M + M M + + + M M M + M + + M M|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 2 2 |
Hyperplasia, Lymphoid | 4 3 2 2 1 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + I + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 3| 3| 3| 1| 3| 3| 3| 3| 2| 8| 3| 3| 3| 2| 1| 3| 3| 9| 8| 3| 3| 2|
| 8| 9| 9| 6| 2| 2| 1| 1| 0| 3| 3| 9| 6| 2| 2| 2| 4| 8| 1| 0| 4| 8| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 3 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Glandular | 2 2 2 1 |
__________________________________________________________________________|
Skin | + |
Inflammation, Chronic Active | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
Hyperostosis | X X X X X X X|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Pigmentation, Hemosiderin | |
Alveolus, Hyperplasia, Macrophage | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capillary, Thrombosis | |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 |
Respiratory Epithelium, Degeneration | 1 2 2 1 2 2 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Inflammation,| |
Suppurative | 1 2 1 2 1 1 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + I + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Metaplasia, Osseous | |
Nephropathy | 3 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 6| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 3| 3| 3| 1| 3| 3| 3| 3| 2| 8| 3| 3| 3| 2| 1| 3| 3| 9| 8| 3| 3| 2|
| 8| 9| 9| 6| 2| 2| 1| 1| 0| 3| 3| 9| 6| 2| 2| 2| 4| 8| 1| 0| 4| 8| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Glomerulus, Thrombosis | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 2| 2| 4| 3| 3| 3| 3| | |
| 2| 0| 1| 2| 6| 3| 1| 9| 9| 9| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/M3 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 63 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M A + + + + + + + + + M + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 64 |
Abscess | | 1 4.0|
Basophilic Focus | | 1 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | | 2 |
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 64 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 64 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 64 |
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 63 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Developmental Malformation | | 1 |
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 64 |
Arteriole, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + | 64 |
Hyperplasia | | 1 1.0|
Vacuolization Cytoplasmic | | 1 3.0|
Spindle Cell, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + | 62 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 2| 2| 4| 3| 3| 3| 3| | |
| 2| 0| 1| 2| 6| 3| 1| 9| 9| 9| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/M3 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Degeneration | | 1 3.0|
Hyperplasia | | 1 2.0|
Spindle Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 63 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + | 63 |
Pars Distalis, Angiectasis | | 7 3.0|
Pars Distalis, Hyperplasia | 2 4 3 1 | 10 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 62 |
Hyperplasia, Cystic | 2 2 3 4 2 1 1 | 26 1.9|
Infiltration Cellular, Lymphocyte | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + + + + | 57 |
Ectasia | 2 | 1 2.0|
Inflammation, Chronic | 1 | 2 2.5|
Pigmentation | 2 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Ovary | + + M + + + + + + + + + + + | 61 |
Abscess | 3 | 2 3.5|
Cyst | X X | 8 |
Inflammation, Suppurative | | 1 3.0|
Rete Ovarii, Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 64 |
Inflammation, Suppurative | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 1 2 1 | 24 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 64 |
Myelofibrosis | 4 | 3 2.0|
Myeloid Cell, Hyperplasia | 3 2 | 5 2.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 15 |
Iliac, Hyperplasia, Lymphoid | 3 3 | 3 3.3|
Renal, Hyperplasia, Lymphoid | 3 3 | 4 3.5|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + I + + + + | 54 |
Hyperplasia, Lymphoid | 3 4 2 2 1 1 1 | 14 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 61 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 2| 2| 4| 3| 3| 3| 3| | |
| 2| 0| 1| 2| 6| 3| 1| 9| 9| 9| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/M3 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 4 3 3 2 | 16 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M + + + + + + + M + + + + | 54 |
Hyperplasia, Lymphoid | 2 1 | 8 2.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + M + + M + + M M | 35 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 64 |
Hematopoietic Cell Proliferation | 3 2 | 8 2.8|
Hyperplasia, Lymphoid | 3 3 2 1 | 12 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + | 59 |
Atrophy | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + | 63 |
Hyperplasia, Glandular | 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Skin | + | 4 |
Inflammation, Chronic Active | 4 | 1 4.0|
Subcutaneous Tissue, Edema | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 64 |
Fracture | X | 1 |
Hyperostosis | X X X X X X X | 17 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 64 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + M + + | 62 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 64 |
Inflammation, Chronic | 2 1 | 7 1.4|
Pigmentation, Hemosiderin | | 2 1.5|
Alveolus, Hyperplasia, Macrophage | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 62 |
Capillary, Thrombosis | | 1 4.0|
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 | 16 1.1|
Respiratory Epithelium, Degeneration | 1 1 2 1 1 1 1 1 | 19 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 2| 2| 4| 3| 3| 3| 3| | |
| 2| 0| 1| 2| 6| 3| 1| 9| 9| 9| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/M3 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Hyperplasia | | 1 1.0|
Respiratory Epithelium, Inflammation,| | |
Suppurative | 1 1 1 | 17 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 10 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 63 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 64 |
Hydronephrosis | 2 | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | | 2 2.5|
Glomerulus, Thrombosis | | 1 2.0|
Renal Tubule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 63 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 9| 3| 3| 3| 2| 2| 9| 0| 3| 2| 6| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 2| 6| 1| 1| 7| 3| 0| 1| 9| 9| 5| 9| 3| 9| 9| 7| 1| 3| 3| 3| 2| 0| 2| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + M + + + A A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + A A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + M + + + A M + M + + + M + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + A A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + A + + + A + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + A + + + A A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + A + M + A A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Inflammation, Chronic, Focal | 2 1|
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| |
Sinusoid, Amyloid Deposition | |
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + I|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 1 4 1 2 |
Pars Distalis, Hyperplasia | 2 3 1 3 3 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 9| 3| 3| 3| 2| 2| 9| 0| 3| 2| 6| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 2| 6| 1| 1| 7| 3| 0| 1| 9| 9| 5| 9| 3| 9| 9| 7| 1| 3| 3| 3| 2| 0| 2| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 2 2 3 2 1 2 1 1 1 1 1|
Inflammation, Suppurative | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | I + + + + + + + M + + + + + + + + + + + + + + + +|
Ectasia | |
Pigmentation | 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Bilateral, Dilatation | 3 |
Endometrium, Hyperplasia, Cystic | 2 4 2 1 2 2 4 2 3 2 1 2 2 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 2 |
Necrosis | |
Myeloid Cell, Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hyperplasia, Lymphoid | 3 3 |
Iliac, Pigmentation | 1 |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + I + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 3 2 2 2 2 2 2 2 2 3 2 2 1 2|
Pigmentation | 1 2 1 2 1 2 2 1 1 2 1 1 2 1 2 2 1 1 2 1 2 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 4 3 4 3 2 2 2 2|
Hyperplasia, Macrophage | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + M + + + + + + + + + + + + +|
Congestion | 3 2 2 |
Ectasia | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + I + + M + + M M M + + M I M + + + M + M + + M|
Hyperplasia, Lymphoid | 4 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 9| 3| 3| 3| 2| 2| 9| 0| 3| 2| 6| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 2| 6| 1| 1| 7| 3| 0| 1| 9| 9| 5| 9| 3| 9| 9| 7| 1| 3| 3| 3| 2| 0| 2| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 2 3 |
Hyperplasia, Lymphoid | 2 2 4 2 3 4 2 2 2 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 3 |
__________________________________________________________________________|
Skin | + + |
Alopecia | |
Pinna, Cyst Epithelial Inclusion | X |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 1 2 4 1 2 X X X X X|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
Pons, Compression | |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | I + + + + + + + + + + + + + + + + + + + + + + + I|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 1 1 1 2 1 2 1 2 1 2 1 2 1 1 1 2 2|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolus, Hyperplasia, Macrophage | 3 2 |
Alveolus, Pigmentation | 2 1 2 2 2 1 1 2 1 2 1 2 1 2 1 1 2 2 1 1 2 1 1 2 1|
Alveolus, Proteinosis | 1 2 2 2 |
__________________________________________________________________________|
Nose | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Degeneration | 1 1 2 1 |
Respiratory Epithelium, Degeneration | 1 2 1 1 1 1 2 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Inflammation,| |
Chronic | |
Respiratory Epithelium, Inflammation,| |
Suppurative | 1 1 1 1 2 1 |
Respiratory Epithelium, Metaplasia, | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 9| 3| 3| 3| 2| 2| 9| 0| 3| 2| 6| 5| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 2| 6| 1| 1| 7| 3| 0| 1| 9| 9| 5| 9| 3| 9| 9| 7| 1| 3| 3| 3| 2| 0| 2| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Squamous | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
External Ear, Hyperkeratosis | 2|
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Nephropathy | |
Pelvis, Infiltration Cellular, | |
Lymphocyte | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 2| 7| 6| 3| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 4| 7| 8| 3| 2| 3| 3| 3| 3| 2| 2| 0| 9| 3| 8| 0| 3| 8| 1| 3| 3| 1|
| 4| 9| 0| 0| 6| 3| 1| 9| 1| 6| 0| 2| 6| 6| 3| 0| 0| 3| 3| 1| 3| 7| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M M + M M + M + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + M|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Inflammation, Chronic, Focal | |
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Sinusoid, Amyloid Deposition | 3 |
__________________________________________________________________________|
Mesentery | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 1 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Spindle Cell, Hyperplasia | 4 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + M + + M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Hyperplasia | 2 2 2|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 2| 7| 6| 3| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 4| 7| 8| 3| 2| 3| 3| 3| 3| 2| 2| 0| 9| 3| 8| 0| 3| 8| 1| 3| 3| 1|
| 4| 9| 0| 0| 6| 3| 1| 9| 1| 6| 0| 2| 6| 6| 3| 0| 0| 3| 3| 1| 3| 7| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 2 1 1 2 3 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + M +|
Ectasia | 2 |
Pigmentation | 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Bilateral, Dilatation | |
Endometrium, Hyperplasia, Cystic | 2 2 3 2 3 3 3 2 1 1 3 1 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + M + + + + + +|
Myelofibrosis | |
Necrosis | 4 |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + +|
Iliac, Hyperplasia, Lymphoid | |
Iliac, Pigmentation | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + + + + +|
Congestion | 1 |
Hyperplasia, Lymphoid | 2 2 2 2 1 3 2 2 2 1 2 1|
Pigmentation | 2 1 2 1 2 1 1 2 2 1 1 1 1 2 1 1 2 1 1 2 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 3 4 2 2 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + M + M I M I I + + + M + M M I + M M M|
Hyperplasia, Lymphoid | 4 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 2| 7| 6| 3| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 4| 7| 8| 3| 2| 3| 3| 3| 3| 2| 2| 0| 9| 3| 8| 0| 3| 8| 1| 3| 3| 1|
| 4| 9| 0| 0| 6| 3| 1| 9| 1| 6| 0| 2| 6| 6| 3| 0| 0| 3| 3| 1| 3| 7| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 4 2 3 |
Hyperplasia, Lymphoid | 2 4 4 2 2 2 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + M + + + + + + + + M I + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 1 |
__________________________________________________________________________|
Skin | + + + + |
Alopecia | 1 |
Pinna, Cyst Epithelial Inclusion | |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + I + + + + + +|
Hyperostosis | X 2 X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | 4 |
Pons, Compression | 4 |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + I + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 |
Inflammation, Chronic | 1 1 3 2 1 1 2 1 1 1 3 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolus, Hyperplasia, Macrophage | |
Alveolus, Pigmentation | 1 1 1 2 2 2 1 1 1 1 2 1 1 2 1 2 1 1 1 1 1 1 1 1|
Alveolus, Proteinosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 |
Respiratory Epithelium, Degeneration | 2 1 1 1 2 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Inflammation,| |
Chronic | |
Respiratory Epithelium, Inflammation,| |
Suppurative | 1 1 2 1 3 1 1 2 2 |
Respiratory Epithelium, Metaplasia, | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 2| 7| 6| 3| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 4| 7| 8| 3| 2| 3| 3| 3| 3| 2| 2| 0| 9| 3| 8| 0| 3| 8| 1| 3| 3| 1|
| 4| 9| 0| 0| 6| 3| 1| 9| 1| 6| 0| 2| 6| 6| 3| 0| 0| 3| 3| 1| 3| 7| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Squamous | 2 1 1 1 1 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
External Ear, Hyperkeratosis | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Nephropathy | 1 4 |
Pelvis, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 1| | |
DAY ON TEST | 3| 3| 3| 5| 9| 3| 4| 3| 3| 2| 3| 2| 1| 3| 3| 6| | |
| 0| 3| 2| 2| 2| 3| 6| 1| 0| 9| 3| 0| 0| 3| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25MGM3 | 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 8| 0| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + A + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + | 61 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + A + M + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + A + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + A + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + A + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + A + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 66 |
Basophilic Focus | | 1 |
Inflammation, Chronic, Focal | 2 | 3 1.7|
Hepatocyte, Hyperplasia | 2 | 1 2.0|
Hepatocyte, Necrosis | 2 | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| | 1 2.0|
Sinusoid, Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Artery, Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + | 66 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + A + + + + + + + + + | 63 |
Hyperkeratosis | 2 2 | 8 1.8|
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + A + + + + + + + + + | 63 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + | 66 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + | 66 |
Hyperplasia | | 2 1.5|
Spindle Cell, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + | 65 |
Spindle Cell, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 1| | |
DAY ON TEST | 3| 3| 3| 5| 9| 3| 4| 3| 3| 2| 3| 2| 1| 3| 3| 6| | |
| 0| 3| 2| 2| 2| 3| 6| 1| 0| 9| 3| 0| 0| 3| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25MGM3 | 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 8| 0| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + M + + + + + M + + M | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + | 66 |
Pars Distalis, Angiectasis | 1 3 4 | 10 2.4|
Pars Distalis, Hyperplasia | 3 | 9 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + | 66 |
Hyperplasia, Cystic | 1 1 2 2 2 | 26 1.7|
Inflammation, Suppurative | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + | 62 |
Ectasia | 2 | 2 2.0|
Pigmentation | | 4 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + | 66 |
Congestion | | 1 2.0|
Cyst | X X | 14 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + | 66 |
Dilatation | | 1 2.0|
Bilateral, Dilatation | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 4 3 3 3 3 | 34 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + | 65 |
Myelofibrosis | | 2 2.5|
Necrosis | | 1 4.0|
Myeloid Cell, Hyperplasia | 3 | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 9 |
Iliac, Hyperplasia, Lymphoid | | 2 3.0|
Iliac, Pigmentation | | 1 1.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + M | 63 |
Congestion | 2 | 2 1.5|
Hyperplasia, Lymphoid | 2 1 3 2 3 2 3 2 2 1 | 37 2.0|
Pigmentation | 1 2 2 2 2 2 2 2 1 1 2 1 2 1 | 58 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + I + + + + + + + + + + + M | 63 |
Congestion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 1| | |
DAY ON TEST | 3| 3| 3| 5| 9| 3| 4| 3| 3| 2| 3| 2| 1| 3| 3| 6| | |
| 0| 3| 2| 2| 2| 3| 6| 1| 0| 9| 3| 0| 0| 3| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25MGM3 | 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 8| 0| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 3 3 4 4 4 3 | 18 3.0|
Hyperplasia, Macrophage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + | 63 |
Congestion | 4 | 4 2.8|
Ectasia | | 1 3.0|
Hyperplasia, Lymphoid | 4 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + I M M I M M + I M + M M + M | 28 |
Hyperplasia, Lymphoid | | 3 3.0|
Pigmentation | | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + | 66 |
Hematopoietic Cell Proliferation | | 6 2.7|
Hyperplasia, Lymphoid | 3 2 | 17 2.6|
Hyperplasia, Macrophage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + | 61 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + | 66 |
Hyperplasia, Glandular | 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Skin | + + | 8 |
Alopecia | | 1 1.0|
Pinna, Cyst Epithelial Inclusion | | 1 |
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + | 65 |
Hyperostosis | X X X X X X X | 25 2.1|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + | 66 |
Hypothalamus, Compression | 2 | 2 3.0|
Pons, Compression | | 1 4.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + | 63 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + | 66 |
Hemorrhage | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 1| | |
DAY ON TEST | 3| 3| 3| 5| 9| 3| 4| 3| 3| 2| 3| 2| 1| 3| 3| 6| | |
| 0| 3| 2| 2| 2| 3| 6| 1| 0| 9| 3| 0| 0| 3| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25MGM3 | 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 8| 0| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 1 1 2 4 1 2 2 1 1 1 | 43 1.4|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 | 35 1.0|
Alveolus, Hyperplasia, Macrophage | | 2 2.5|
Alveolus, Pigmentation | 1 1 1 1 1 1 2 2 1 2 1 1 1 1 1 | 64 1.3|
Alveolus, Proteinosis | 1 1 1 | 8 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 65 |
Inflammation, Suppurative | | 1 1.0|
Olfactory Epithelium, Degeneration | 1 | 10 1.1|
Respiratory Epithelium, Degeneration | 1 1 1 | 15 1.3|
Respiratory Epithelium, Hyperplasia | | 1 1.0|
Respiratory Epithelium, Inflammation,| | |
Chronic | 1 | 1 1.0|
Respiratory Epithelium, Inflammation,| | |
Suppurative | 2 2 1 | 18 1.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 9 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + | 66 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
External Ear, Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + | 66 |
Inflammation, Chronic | | 1 2.0|
Nephropathy | 1 | 3 2.0|
Pelvis, Infiltration Cellular, | | |
Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + M + + + + | 62 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 3| 0| 6| 5| 5| 5| 5| 7| 7| 5| 3| 3| 7| 0| 7| 7| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 5| 3| 1| 3| 4| 7| 6| 3| 8| 3| 2| 8| 2| 2| 2| 1| 3| 3| 3| 7|
| 9| 1| 3| 6| 2| 1| 3| 5| 6| 0| 0| 6| 8| 4| 2| 9| 7| 1| 6| 9| 9| 6| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + A + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + A + + + + + + + + + + + + M M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + A + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + A + + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + A + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + A + + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | |
Inflammation, Chronic, Focal | 1 1 |
Mixed Cell Focus | |
Hepatocyte, Fatty Change | 2 |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | 2 |
Cyst | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 3| 0| 6| 5| 5| 5| 5| 7| 7| 5| 3| 3| 7| 0| 7| 7| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 5| 3| 1| 3| 4| 7| 6| 3| 8| 3| 2| 8| 2| 2| 2| 1| 3| 3| 3| 7|
| 9| 1| 3| 6| 2| 1| 3| 5| 6| 0| 0| 6| 8| 4| 2| 9| 7| 1| 6| 9| 9| 6| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M + + M + M + M M M + + + + + + + M M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Angiectasis | 1 3 3 |
Pars Distalis, Hyperplasia | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 1 1 1 3 1 4 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + I + + + + M + + + + + + + + + + + + + +|
Pigmentation | 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cyst | X X X X X |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Endometrium, Hyperplasia, Cystic | 2 3 2 2 2 2 2 2 3 1 4 1 4 3 1 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + M + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + +|
Iliac, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + I + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 2 1 3 2 3 1 2 2 1 2 2 |
Pigmentation | 1 2 1 2 2 2 1 1 2 2 2 2 1 2 1 1 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + M + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 3 4 1 2 3 3 4 4|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + M + + + + M + + + + M + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 4 2 2 2 |
Inflammation, Chronic Active | 3|
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + I + + + M M + + + + M M + I + + + M + + M +|
Hyperplasia, Lymphoid | 4 3 3 |
Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 3| 0| 6| 5| 5| 5| 5| 7| 7| 5| 3| 3| 7| 0| 7| 7| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 5| 3| 1| 3| 4| 7| 6| 3| 8| 3| 2| 8| 2| 2| 2| 1| 3| 3| 3| 7|
| 9| 1| 3| 6| 2| 1| 3| 5| 6| 0| 0| 6| 8| 4| 2| 9| 7| 1| 6| 9| 9| 6| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 2 2 2 |
Hyperplasia, Lymphoid | 2 2 2 3 4 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 2 |
__________________________________________________________________________|
Skin | + + +|
Alopecia | |
Inflammation, Suppurative | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 1 X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | 2 X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + M + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic | 1 1 1 2 2 2 2 1 1 1 1 2 2 1 2 2 2 1 1|
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolus, Hemorrhage | |
Alveolus, Pigmentation | 2 2 2 2 1 1 1 2 2 2 2 2 2 2 2 2 2 1 2 1 2 1 2 2|
Alveolus, Proteinosis | 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + A + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration | 2 2 |
Respiratory Epithelium, Degeneration | 1 1 |
Respiratory Epithelium, Inflammation,| |
Suppurative | 1 1 1 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 3| 0| 6| 5| 5| 5| 5| 7| 7| 5| 3| 3| 7| 0| 7| 7| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 5| 3| 1| 3| 4| 7| 6| 3| 8| 3| 2| 8| 2| 2| 2| 1| 3| 3| 3| 7|
| 9| 1| 3| 6| 2| 1| 3| 5| 6| 0| 0| 6| 8| 4| 2| 9| 7| 1| 6| 9| 9| 6| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 3 |
Nephropathy | |
Medulla, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 2| 7| 8| 3| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 7| 3| 5| 3| 3| 3| 3|
| 3| 3| 9| 3| 9| 0| 1| 3| 6| 2| 0| 9| 9| 0| 1| 9| 0| 2| 6| 0| 8| 1| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + M M + + + A + + + + + + + + M + M A M + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + A + + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | 2|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + A + + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + A + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + A + + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | X X |
Inflammation, Chronic, Focal | 2 |
Mixed Cell Focus | |
Hepatocyte, Fatty Change | |
Hepatocyte, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Congestion | |
Cyst | X |
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 2| 7| 8| 3| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 7| 3| 5| 3| 3| 3| 3|
| 3| 3| 9| 3| 9| 0| 1| 3| 6| 2| 0| 9| 9| 0| 1| 9| 0| 2| 6| 0| 8| 1| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + M + + + + + + + + + + + + M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 1 2 |
Pars Distalis, Hyperplasia | 4 4 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 2 2 2 2 1 1 4 1 1 1 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | I M + + + + + + + + + + + + + + + + + + + + + M M|
Pigmentation | 2 1 2 |
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Inflammation, Suppurative | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Endometrium, Hyperplasia, Cystic | 2 2 1 2 2 2 2 3 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Myeloid Cell, Hyperplasia | 3 4 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + + + + M + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 2 2 2 2 1 2 3 3 1 1 2 2 2 2 1 2|
Pigmentation | 2 2 1 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 2 3 4 2 2 4 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + M + + + + + + + + + + + M + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 2 3 2|
Inflammation, Chronic Active | |
Inflammation | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M M + + M M M M + M M M M I + M M + + M M|
Hyperplasia, Lymphoid | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 2| 7| 8| 3| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 7| 3| 5| 3| 3| 3| 3|
| 3| 3| 9| 3| 9| 0| 1| 3| 6| 2| 0| 9| 9| 0| 1| 9| 0| 2| 6| 0| 8| 1| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 2 |
Hyperplasia, Lymphoid | 3 2 2 1 2 2 3 1 2 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + I + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 2 1 1 2 |
__________________________________________________________________________|
Skin | + + |
Alopecia | X |
Inflammation, Suppurative | 4 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X X 2 X X X X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic | 3 2 2 3 1 1 1 2 2 2 1 3 2 1 2 2 1 1 2 1 1|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Alveolus, Hemorrhage | |
Alveolus, Pigmentation | 2 2 3 2 1 2 1 2 1 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2|
Alveolus, Proteinosis | 1 2 2 1 1 2 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration | |
Respiratory Epithelium, Degeneration | 1 2 1 2 1 1 |
Respiratory Epithelium, Inflammation,| |
Suppurative | 1 2 1 3 1 2 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 2 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 2| 7| 8| 3| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 7| 3| 5| 3| 3| 3| 3|
| 3| 3| 9| 3| 9| 0| 1| 3| 6| 2| 0| 9| 9| 0| 1| 9| 0| 2| 6| 0| 8| 1| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 3 |
Nephropathy | 1 1 |
Medulla, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 3| 2| 3| 5| 5| 3| 3| 6| 3| 3| 3| 2| | |
| 9| 0| 6| 9| 6| 9| 9| 2| 3| 9| 0| 3| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| | L |
| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 2| 3| 8| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 63 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + + + + + | 57 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + M + A + + + M M M M | 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + | 57 |
Hyperplasia, Lymphoid | | 4 2.3|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + | 56 |
Hyperplasia, Lymphoid | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 63 |
Basophilic Focus | 1 | 1 1.0|
Clear Cell Focus | | 1 |
Eosinophilic Focus | | 2 |
Inflammation, Chronic, Focal | | 3 1.3|
Mixed Cell Focus | X | 1 |
Hepatocyte, Fatty Change | | 1 2.0|
Hepatocyte, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + | 62 |
Atrophy | | 1 3.0|
Congestion | | 1 2.0|
Cyst | | 1 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + | 63 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + + + + | 62 |
Hyperkeratosis | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + | 62 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + | 63 |
Inflammation, Chronic Active | | 1 1.0|
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 3| 2| 3| 5| 5| 3| 3| 6| 3| 3| 3| 2| | |
| 9| 0| 6| 9| 6| 9| 9| 2| 3| 9| 0| 3| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| | L |
| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 2| 3| 8| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + | 63 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + | 63 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + | 62 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + | 61 |
Pars Distalis, Angiectasis | 2 2 1 3 | 11 2.1|
Pars Distalis, Hyperplasia | | 4 3.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + | 63 |
Hyperplasia, Cystic | 1 1 1 3 1 1 1 | 32 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + | 57 |
Pigmentation | | 5 1.4|
__________________________________________________________________________|____________|
Ovary | + + + + + M + + + + + + + | 60 |
Cyst | X X | 9 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + A + + + + + + + | 62 |
Cyst | X | 1 |
Endometrium, Hyperplasia, Cystic | 2 3 2 | 30 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 62 |
Necrosis | | 1 2.0|
Myeloid Cell, Hyperplasia | 2 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 10 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + | 59 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | 2 1 3 2 2 1 2 3 1 1 3 | 40 1.9|
Pigmentation | 2 2 2 2 2 3 2 1 2 2 2 1 | 56 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + A + + M + + + + | 59 |
Congestion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 3| 2| 3| 5| 5| 3| 3| 6| 3| 3| 3| 2| | |
| 9| 0| 6| 9| 6| 9| 9| 2| 3| 9| 0| 3| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| | L |
| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 2| 3| 8| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 4 3 | 18 2.9|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + A + + + + + M + | 54 |
Congestion | | 1 3.0|
Hyperplasia, Lymphoid | 1 | 8 2.3|
Inflammation, Chronic Active | | 1 3.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + + + I + M + + M M | 33 |
Hyperplasia, Lymphoid | | 3 3.3|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 63 |
Hematopoietic Cell Proliferation | | 8 2.8|
Hyperplasia, Lymphoid | 1 2 2 2 2 3 | 22 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + | 60 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + | 63 |
Hyperplasia, Glandular | 1 2 2 | 8 1.6|
__________________________________________________________________________|____________|
Skin | + | 6 |
Alopecia | | 1 |
Inflammation, Suppurative | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + | 63 |
Hyperostosis | X X X X X X X X | 26 1.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 63 |
Hypothalamus, Compression | X | 6 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + | 62 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 63 |
Fibrosis | 2 | 1 2.0|
Inflammation, Chronic | 2 1 1 2 2 1 1 2 1 2 2 2 1 | 53 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 3| 2| 3| 5| 5| 3| 3| 6| 3| 3| 3| 2| | |
| 9| 0| 6| 9| 6| 9| 9| 2| 3| 9| 0| 3| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| | L |
| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 2| 3| 8| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 | 39 1.0|
Alveolus, Hemorrhage | 2 | 1 2.0|
Alveolus, Pigmentation | 2 2 2 2 2 2 2 2 2 3 2 2 2 | 61 1.9|
Alveolus, Proteinosis | 1 1 1 3 1 | 17 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 62 |
Olfactory Epithelium, Degeneration | | 2 2.0|
Respiratory Epithelium, Degeneration | 1 2 1 | 11 1.3|
Respiratory Epithelium, Inflammation,| | |
Suppurative | 1 1 1 1 1 | 18 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 1 1 | 14 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + | 63 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 63 |
Infiltration Cellular, Lymphocyte | | 2 2.0|
Inflammation, Chronic | | 2 3.0|
Nephropathy | 3 | 3 1.7|
Medulla, Cyst | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + | 60 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M M + + + + + + + + + + + A M + + + + + M + M M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + A + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Hepatocyte, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | +|
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Spindle Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + I + + + + + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 4 2 |
Pars Distalis, Hyperplasia | 3 2 4 |
Pars Distalis, Necrosis | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 1 1 3 1 1 3 2 1 3 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + M + + M +|
Ectasia | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Pigmentation | 2 2 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 4 3 2 2 2 3 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Iliac, Hyperplasia, Macrophage | 2 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 3 4 |
Renal, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 3 1 2 2 2 2 3 1 3 2 1 2 1 2 2 2 1 1|
Pigmentation | 2 2 2 2 2 2 1 1 2 1 1 2 2 2 2 1 2 2 3 1 2 3 2 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 3 1 3 4 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 2 1 1 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + I + + M + I + + M M + M + + M M + I + M M M + I|
Hyperplasia, Lymphoid | 4 |
Pigmentation | 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 2 3 3 3 2 2 |
Hyperplasia, Macrophage | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + M + + + + M I + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 2 3 1 1 |
__________________________________________________________________________|
Skin | + + + + + |
Alopecia | 2 |
Edema | |
Hemorrhage | 2 |
Inflammation, Chronic | 4 |
Epidermis, Inflammation, Suppurative | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X X X X X X X |
Pelvis, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | X X 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Inflammation, Chronic | 2 1 1 2 1 3 1 2 1 4 1 3 3 2 2 3 1 2 3 2 3|
Metaplasia, Squamous | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Alveolus, Pigmentation | 3 2 2 3 3 2 3 2 2 3 1 2 2 2 2 2 2 2 3 1 2 3 2 3 3|
Alveolus, Proteinosis | 1 2 2 2 2 1 2 1 3 2 2 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration | 1 1 1 2 |
Respiratory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 1 1|
Respiratory Epithelium, Inflammation,| |
Suppurative | 2 1 1 2 1 1 1 1 1 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 2 3 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cornea, Inflammation | 2 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Nephropathy | 1 |
Cortex, Cyst | |
__________________________________________________________________________|
Urethra | |
Concretion | |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 4| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7|
DAY ON TEST | 3| 4| 2| 4| 7| 6| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 9| 3| 9| 5| 3|
| 3| 4| 9| 4| 3| 9| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 6| 1| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/M3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + A + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | M M + + + + + + + + M A + + + A M M + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + A + + + + + A + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + A + + + A + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | 4 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + A + + + A + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + A + + + A + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M + + M + + + M + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 2 2 1 |
Pars Distalis, Necrosis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 2 2 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 4| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7|
DAY ON TEST | 3| 4| 2| 4| 7| 6| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 9| 3| 9| 5| 3|
| 3| 4| 9| 4| 3| 9| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 6| 1| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/M3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + M + + + + + + + + + + + +|
Ectasia | 1 2 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 4 |
Pigmentation | 2 1 2 2 2 2 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 1 3 3 2 3 2 3 3 1 3 2 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Macrophage | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
Renal, Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + + + + + + + + + + M + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 2 3 2 4 3 2 2 2 2 2 2 3 1 2 3|
Pigmentation | 3 2 2 1 2 1 2 2 2 2 2 1 2 3 2 2 3 2 2 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 4 3 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + M M + + M + + + M + + + +|
Congestion | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 2 3|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + + M M + M M M I M M + M + + M + + M|
Hyperplasia, Lymphoid | |
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 3 3 2 3|
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 4| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7|
DAY ON TEST | 3| 4| 2| 4| 7| 6| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 9| 3| 9| 5| 3|
| 3| 4| 9| 4| 3| 9| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 6| 1| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/M3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 3 2 3 |
__________________________________________________________________________|
Skin | + + + + |
Alopecia | |
Edema | 3 |
Hemorrhage | 2 |
Inflammation, Chronic | |
Epidermis, Inflammation, Suppurative | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 |
Subcutaneous Tissue, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + I + + + + +|
Hyperostosis | X X 2 X X 4 |
Pelvis, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 |
Inflammation, Chronic | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 1 1 2|
Metaplasia, Squamous | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolus, Pigmentation | 2 3 3 3 2 2 2 1 3 2 3 2 2 3 2 2 3 3 2 2 4 2 1 3|
Alveolus, Proteinosis | 1 2 3 2 1 3 2 1 1 2 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration | 1 1 3 |
Respiratory Epithelium, Degeneration | 1 1 1 2 |
Respiratory Epithelium, Inflammation,| |
Suppurative | 2 3 3 1 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 3 3 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 4| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 6| 7| 4| 6| 7|
DAY ON TEST | 3| 4| 2| 4| 7| 6| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 9| 3| 9| 5| 3|
| 3| 4| 9| 4| 3| 9| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 6| 1| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/M3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cornea, Inflammation | 2 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
Nephropathy | 2 |
Cortex, Cyst | X |
__________________________________________________________________________|
Urethra | + |
Concretion | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 8| 3| 8| 3| 3| 2| 4| 3| 3| 3| 9| 3| 2| 3| 2| | |
| 4| 3| 4| 0| 0| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
5.0MG/M3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 4| 5| 6| 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + A + + + + + + + | 63 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + A + + M + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + A + + A + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + A + M A + + M M | 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + A + + A + + + + | 56 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + A + + A + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + A + + A + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + A A + + A + + + + | 54 |
__________________________________________________________________________|____________|
Liver | + + + + + + + A + + + + + + + | 63 |
Basophilic Focus | | 1 |
Clear Cell Focus | | 1 |
Hepatocyte, Necrosis | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Inflammation, Chronic Active | | 1 4.0|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A + + + + + + + | 62 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + A + + + + + + + | 63 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + A + + A + + + + | 60 |
Hyperkeratosis | 3 | 1 3.0|
Hyperplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + A + + + + | 60 |
__________________________________________________________________________|____________|
Tooth | | 2 |
Developmental Malformation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 64 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + A + + + + + + + | 62 |
Hyperplasia | | 1 1.0|
Spindle Cell, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + A + + + + + + + | 62 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A + + + + + + + | 62 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + A + + + + + + + | 62 |
Pars Distalis, Angiectasis | 3 3 1 | 7 2.6|
Pars Distalis, Hyperplasia | 2 2 | 9 2.2|
Pars Distalis, Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 8| 3| 8| 3| 3| 2| 4| 3| 3| 3| 9| 3| 2| 3| 2| | |
| 4| 3| 4| 0| 0| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
5.0MG/M3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 4| 5| 6| 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 64 |
Hyperplasia, Cystic | 4 3 2 1 | 26 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + M M A + + + + + + + | 55 |
Ectasia | | 3 1.7|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
Pigmentation | 1 2 | 12 1.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + A + + + + + + + | 63 |
Angiectasis | | 2 2.5|
Cyst | X X X | 7 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + A + + + + + + + | 63 |
Inflammation, Suppurative | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 2 1 1 2 | 29 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + A + + + + + + + | 63 |
Myelofibrosis | 3 | 2 2.5|
Myeloid Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 9 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Iliac, Hyperplasia, Macrophage | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 2 3.5|
Renal, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + | 62 |
Congestion | | 2 3.0|
Hyperplasia, Lymphoid | 4 3 2 2 2 3 2 3 2 3 2 | 44 2.2|
Pigmentation | 2 2 2 3 2 2 2 3 1 3 2 3 2 3 3 | 60 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + A + + M + + + + | 58 |
Hyperplasia, Lymphoid | 4 4 4 | 14 3.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + M + + M + + + + | 55 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 2 2 | 13 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 8| 3| 8| 3| 3| 2| 4| 3| 3| 3| 9| 3| 2| 3| 2| | |
| 4| 3| 4| 0| 0| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
5.0MG/M3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 4| 5| 6| 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M M M M M M + + + M + M M | 29 |
Hyperplasia, Lymphoid | 2 | 2 3.0|
Pigmentation | 1 2 | 5 1.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + + + + + + | 63 |
Congestion | | 2 4.0|
Hematopoietic Cell Proliferation | 3 2 | 5 2.2|
Hyperplasia, Lymphoid | 2 1 2 3 2 | 17 2.4|
Hyperplasia, Macrophage | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + M + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + A + + + + + + + | 63 |
Hyperplasia, Glandular | 3 | 8 2.3|
__________________________________________________________________________|____________|
Skin | + + + | 12 |
Alopecia | | 1 2.0|
Edema | | 1 3.0|
Hemorrhage | | 2 2.0|
Inflammation, Chronic | | 1 4.0|
Epidermis, Inflammation, Suppurative | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
Subcutaneous Tissue, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 63 |
Hyperostosis | X X X X X X X X X X | 24 3.0|
Pelvis, Fracture | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 64 |
Hypothalamus, Compression | | 4 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + A + + + + + + + | 63 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 64 |
Fibrosis | | 3 1.0|
Inflammation, Chronic | 3 2 1 2 1 2 1 1 2 1 2 2 | 52 1.9|
Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 8| 3| 8| 3| 3| 2| 4| 3| 3| 3| 9| 3| 2| 3| 2| | |
| 4| 3| 4| 0| 0| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
5.0MG/M3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 4| 5| 6| 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 1 | 40 1.0|
Alveolus, Pigmentation | 2 2 2 3 3 2 2 3 3 2 2 4 2 3 3 | 64 2.4|
Alveolus, Proteinosis | 1 1 2 1 | 29 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + A + + A + + + + | 62 |
Olfactory Epithelium, Degeneration | | 7 1.4|
Respiratory Epithelium, Degeneration | 1 1 1 | 17 1.1|
Respiratory Epithelium, Inflammation,| | |
Suppurative | 1 1 1 1 2 | 21 1.6|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 3 | 15 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + A + + + + + + + | 63 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation | | 2 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + A + + + + + + + | 63 |
Necrosis | | 1 3.0|
Nephropathy | | 2 1.5|
Cortex, Cyst | | 1 |
__________________________________________________________________________|____________|
Urethra | | 1 |
Concretion | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + A + + A + + + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 5| 7| 7| 2| 5| 5| 5| 6| 5| 5| 7| 6| 6| 7| 5| 4| 0| 7| 1| 6| 1|
DAY ON TEST | 6| 3| 3| 7| 8| 3| 3| 9| 5| 1| 9| 6| 5| 1| 3| 0| 0| 3| 0| 3| 0| 3| 6| 9| 6|
| 0| 7| 7| 5| 4| 8| 7| 0| 9| 2| 9| 6| 9| 0| 8| 2| 7| 8| 8| 0| 8| 8| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + M + + + + + + + M + + + + + + M + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cyst | X |
Hyperplasia, Macrophage | |
Hepatocyte, Cytomegaly | |
Hepatocyte, Cytoplasmic Alteration | 2 |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + A + + M M M + + M M + + + + M + M M + M|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 5| 7| 7| 2| 5| 5| 5| 6| 5| 5| 7| 6| 6| 7| 5| 4| 0| 7| 1| 6| 1|
DAY ON TEST | 6| 3| 3| 7| 8| 3| 3| 9| 5| 1| 9| 6| 5| 1| 3| 0| 0| 3| 0| 3| 0| 3| 6| 9| 6|
| 0| 7| 7| 5| 4| 8| 7| 0| 9| 2| 9| 6| 9| 0| 8| 2| 7| 8| 8| 0| 8| 8| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | + + + + + + + |
Concretion | 2 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 4 4 4 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 1 2 3 2 2 2|
Inflammation, Chronic | 4 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 4 4 4 4 4 4 1 2 |
Bilateral, Ectasia | 2 4 3 3 2 3 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + M M +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + A + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Iliac, Hyperplasia, Histiocytic | 2 |
Iliac, Hyperplasia, Lymphoid | 3 2 2 2 2 |
Inguinal, Hyperplasia, Lymphoid | 2 2 2 2 2 |
Inguinal, Hyperplasia | 2 |
Inguinal, Pigmentation | 1|
Pancreatic, Inflammation, | |
Granulomatous | |
Renal, Hyperplasia, Histiocytic | 2 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + I + + M + + + + + + + + + + + I +|
Congestion | |
Hyperplasia, Lymphoid | 1 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + A + + + + + + + + + + + M M + M + + + +|
Hyperplasia, Lymphoid | 1 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + M + + + + + + + + + + + + + M + M|
Congestion | 1 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 5| 7| 7| 2| 5| 5| 5| 6| 5| 5| 7| 6| 6| 7| 5| 4| 0| 7| 1| 6| 1|
DAY ON TEST | 6| 3| 3| 7| 8| 3| 3| 9| 5| 1| 9| 6| 5| 1| 3| 0| 0| 3| 0| 3| 0| 3| 6| 9| 6|
| 0| 7| 7| 5| 4| 8| 7| 0| 9| 2| 9| 6| 9| 0| 8| 2| 7| 8| 8| 0| 8| 8| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M M M + + M M M M M M + I M M M + M M M + M|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + M + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 1 1 3 3 2 2 1 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + M M + + + + + M + + + M M + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + |
Alopecia | X |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 4 4 4 4 3 4 4 3 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | |
Hyperostosis | 1 |
Vertebra, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Nose | + + + + A + + + + + + + + + + + + + + + + + + +|
Respiratory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Inflammation,| |
Suppurative | 1 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + I|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 5| 7| 7| 2| 5| 5| 5| 6| 5| 5| 7| 6| 6| 7| 5| 4| 0| 7| 1| 6| 1|
DAY ON TEST | 6| 3| 3| 7| 8| 3| 3| 9| 5| 1| 9| 6| 5| 1| 3| 0| 0| 3| 0| 3| 0| 3| 6| 9| 6|
| 0| 7| 7| 5| 4| 8| 7| 0| 9| 2| 9| 6| 9| 0| 8| 2| 7| 8| 8| 0| 8| 8| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic Active | |
Mineralization | |
Nephropathy | 2 |
Bilateral, Inflammation, Suppurative | |
Bilateral, Papilla, Inflammation, | |
Suppurative | |
Bilateral, Pelvis, Dilatation | |
Cortex, Cyst | |
Cortex, Fibrosis | |
Pelvis, Dilatation | 2 2 2 2 1 |
Pelvis, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
Concretion | |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 4 |
Transitional Epithelium, Hyperplasia | |
Transitional Epithelium, Metaplasia, | |
Squamous | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 1| 7| 3| 7| 7| 6| 7| 4| 7| 7| 5| 7| 7| 3| 6| 7| 7| 6| 6| 6| 5| 5| 6| 7| 7|
DAY ON TEST | 6| 3| 9| 3| 3| 8| 3| 7| 3| 3| 9| 1| 3| 4| 0| 3| 3| 9| 2| 4| 9| 5| 2| 3| 3|
| 2| 9| 2| 7| 9| 9| 7| 0| 8| 8| 3| 3| 2| 1| 3| 7| 7| 4| 9| 3| 0| 9| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 7| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Gallbladder | A + A + + + + M + + + + + M + + + + + + A M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + M A A M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + A A + + +|
Inflammation, Suppurative | 4 |
Ulcer | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Cyst | |
Hyperplasia, Macrophage | |
Hepatocyte, Cytomegaly | |
Hepatocyte, Cytoplasmic Alteration | |
Hepatocyte, Necrosis | 2 1 4 3 4 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Dysplasia | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + M + + M + + + + + M + + + + M + M +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 1| 7| 3| 7| 7| 6| 7| 4| 7| 7| 5| 7| 7| 3| 6| 7| 7| 6| 6| 6| 5| 5| 6| 7| 7|
DAY ON TEST | 6| 3| 9| 3| 3| 8| 3| 7| 3| 3| 9| 1| 3| 4| 0| 3| 3| 9| 2| 4| 9| 5| 2| 3| 3|
| 2| 9| 2| 7| 9| 9| 7| 0| 8| 8| 3| 3| 2| 1| 3| 7| 7| 4| 9| 3| 0| 9| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 7| 0| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Penis | |
Concretion | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 4 3 3 2 4 1|
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 4 4 4 4 3 3 3|
Inflammation, Suppurative | 3 4 4 |
Bilateral, Ectasia | 1 2 3 4 4 3 2 3 3 2 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + A + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Iliac, Hyperplasia, Histiocytic | |
Iliac, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Lymphoid | 1 2 3 2 3 4 |
Inguinal, Hyperplasia | |
Inguinal, Pigmentation | |
Pancreatic, Inflammation, | |
Granulomatous | 4 |
Renal, Hyperplasia, Histiocytic | |
Renal, Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + I + I + + + M + + M + + + I + + + +|
Congestion | 4 |
Hyperplasia, Lymphoid | 4 2 1 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + M M + + + + + + + + + + M + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + M + + + + + + M + + + + + + + I + M + +|
Congestion | 4 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 1| 7| 3| 7| 7| 6| 7| 4| 7| 7| 5| 7| 7| 3| 6| 7| 7| 6| 6| 6| 5| 5| 6| 7| 7|
DAY ON TEST | 6| 3| 9| 3| 3| 8| 3| 7| 3| 3| 9| 1| 3| 4| 0| 3| 3| 9| 2| 4| 9| 5| 2| 3| 3|
| 2| 9| 2| 7| 9| 9| 7| 0| 8| 8| 3| 3| 2| 1| 3| 7| 7| 4| 9| 3| 0| 9| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 7| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 4 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M M M + + M + + M M M + M I M M M M + M M +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 2 2 2 1 |
Hyperplasia, Lymphoid | 2 4 |
__________________________________________________________________________|
Thymus | + + M M + + M + + + + M + + + + + + + M I + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + |
Alopecia | |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 3 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | X |
Hyperostosis | 2 |
Vertebra, Inflammation, Suppurative | |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + I + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Respiratory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Inflammation,| |
Suppurative | 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 1| 7| 3| 7| 7| 6| 7| 4| 7| 7| 5| 7| 7| 3| 6| 7| 7| 6| 6| 6| 5| 5| 6| 7| 7|
DAY ON TEST | 6| 3| 9| 3| 3| 8| 3| 7| 3| 3| 9| 1| 3| 4| 0| 3| 3| 9| 2| 4| 9| 5| 2| 3| 3|
| 2| 9| 2| 7| 9| 9| 7| 0| 8| 8| 3| 3| 2| 1| 3| 7| 7| 4| 9| 3| 0| 9| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 7| 0| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Inflammation, Chronic Active | |
Mineralization | |
Nephropathy | |
Bilateral, Inflammation, Suppurative | 4 |
Bilateral, Papilla, Inflammation, | |
Suppurative | 2 |
Bilateral, Pelvis, Dilatation | 1 |
Cortex, Cyst | X |
Cortex, Fibrosis | 1 |
Pelvis, Dilatation | 3 2 2 |
Pelvis, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
Concretion | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 4 |
Inflammation, Suppurative | 4 |
Transitional Epithelium, Hyperplasia | 2 |
Transitional Epithelium, Metaplasia, | |
Squamous | 2 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 0| 7| 7| 7| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 5| 0| 3| 0| 3| 3| 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 3| 1| 9| 4| 9| 9| 3| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + A + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + A + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M A + A + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A + + M + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + + | 51 |
Inflammation, Suppurative | | 1 4.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 57 |
Basophilic Focus | | 1 1.0|
Cyst | | 1 |
Hyperplasia, Macrophage | 2 | 1 2.0|
Hepatocyte, Cytomegaly | 1 | 1 1.0|
Hepatocyte, Cytoplasmic Alteration | | 1 2.0|
Hepatocyte, Necrosis | | 5 2.8|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | M + + M + + + + | 54 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + | 55 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
Dysplasia | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 57 |
Hyperplasia | 1 | 6 1.3|
Spindle Cell, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | M + + M + + + + | 54 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + + | 37 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 0| 7| 7| 7| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 5| 0| 3| 0| 3| 3| 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 3| 1| 9| 4| 9| 9| 3| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + | 55 |
Hyperplasia, Cystic | 2 2 2 2 1 | 13 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Abscess | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 56 |
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Penis | | 7 |
Concretion | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 5 3.4|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 57 |
Ectasia | 3 3 | 16 2.4|
Inflammation, Chronic | | 2 3.5|
Inflammation, Chronic Active | 4 2 | 9 3.4|
Inflammation, Suppurative | 4 3 4 | 14 3.5|
Bilateral, Ectasia | 2 4 | 23 2.8|
__________________________________________________________________________|____________|
Prostate | + + + M + + + + | 53 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 55 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 57 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 56 |
Myeloid Cell, Hyperplasia | 3 3 | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + + | 22 |
Iliac, Hyperplasia, Histiocytic | | 1 2.0|
Iliac, Hyperplasia, Lymphoid | 3 3 | 8 2.4|
Inguinal, Hyperplasia, Lymphoid | 2 | 12 2.3|
Inguinal, Hyperplasia | | 1 2.0|
Inguinal, Pigmentation | | 1 1.0|
Pancreatic, Inflammation, | | |
Granulomatous | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 0| 7| 7| 7| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 5| 0| 3| 0| 3| 3| 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 3| 1| 9| 4| 9| 9| 3| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hyperplasia, Histiocytic | | 1 2.0|
Renal, Hyperplasia, Lymphoid | 3 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + I + + | 45 |
Congestion | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 5 2.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M + + + | 47 |
Hyperplasia, Lymphoid | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M M M + + | 45 |
Congestion | 3 | 4 2.5|
Hyperplasia, Lymphoid | 3 | 3 3.3|
Inflammation, Suppurative | 3 | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + M M + + M | 18 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 56 |
Hematopoietic Cell Proliferation | 4 | 17 2.1|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + | 45 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Skin | + | 16 |
Alopecia | | 1 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | 4 | 13 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 57 |
Fracture Healed | X | 2 |
Hyperostosis | | 2 1.5|
Vertebra, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 0| 7| 7| 7| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 5| 0| 3| 0| 3| 3| 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 3| 1| 9| 4| 9| 9| 3| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 57 |
Alveolar Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + A + + + + | 55 |
Respiratory Epithelium, Degeneration | | 2 1.0|
Respiratory Epithelium, Inflammation,| | |
Suppurative | 1 | 6 1.2|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 57 |
Atrophy | | 1 4.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | 1 | 1 1.0|
Nephropathy | | 1 2.0|
Bilateral, Inflammation, Suppurative | | 1 4.0|
Bilateral, Papilla, Inflammation, | | |
Suppurative | | 1 2.0|
Bilateral, Pelvis, Dilatation | | 1 1.0|
Cortex, Cyst | | 1 |
Cortex, Fibrosis | | 1 1.0|
Pelvis, Dilatation | 2 | 9 2.0|
Pelvis, Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Urethra | + + | 2 |
Calculus Micro Observation Only | X | 1 |
Concretion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + | 54 |
Calculus Micro Observation Only | | 1 |
Inflammation, Chronic | 4 | 1 4.0|
Inflammation, Chronic Active | | 1 4.0|
Inflammation, Suppurative | | 2 4.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
Transitional Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 6| 7| 7| 7| 7| 1| 5| 7| 7| 5| 7| 6| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 1| 1| 7| 9| 4| 6| 3| 3| 3| 3| 0| 5| 3| 3| 0| 3| 1| 3| 7|
| 8| 6| 7| 9| 9| 8| 2| 2| 6| 4| 1| 9| 8| 9| 8| 9| 5| 7| 9| 8| 1| 8| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + M A A + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + M + M + + + M M A + + + M M + + M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + A + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + A + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + A + A + + M + + A + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X |
Infarct | 3 |
Mixed Cell Focus | X |
Thrombosis | X |
Hepatocyte, Hyperplasia | 2 |
Hepatocyte, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | 3 |
Thrombosis | X |
Vein, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
Bilateral, Hyperplasia | 2 |
Spindle Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 6| 7| 7| 7| 7| 1| 5| 7| 7| 5| 7| 6| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 1| 1| 7| 9| 4| 6| 3| 3| 3| 3| 0| 5| 3| 3| 0| 3| 1| 3| 7|
| 8| 6| 7| 9| 9| 8| 2| 2| 6| 4| 1| 9| 8| 9| 8| 9| 5| 7| 9| 8| 1| 8| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + M + M + M M + M +|
Cyst | |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 1 2 1 2 2 2 1 2 3 2|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Penis | + + +|
Concretion | 4 4|
Hemorrhage | |
Inflammation | |
Inflammation, Suppurative | 4 |
Mineralization | |
Necrosis, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 1 |
Ectasia | 2 2 2 3 3 2 3 |
Hemorrhage | |
Inflammation, Chronic | 3 2 4 |
Inflammation, Chronic Active | 4 4 2|
Inflammation, Suppurative | 3 |
Bilateral, Ectasia | 4 3 4 3 3 3 3 3 3 4 3 4 3|
Bilateral, Inflammation, Chronic | |
Active | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + M + + + + + + M + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 3 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 6| 7| 7| 7| 7| 1| 5| 7| 7| 5| 7| 6| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 1| 1| 7| 9| 4| 6| 3| 3| 3| 3| 0| 5| 3| 3| 0| 3| 1| 3| 7|
| 8| 6| 7| 9| 9| 8| 2| 2| 6| 4| 1| 9| 8| 9| 8| 9| 5| 7| 9| 8| 1| 8| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 4 3 4 |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hyperplasia, Lymphoid | 2 |
Iliac, Inflammation, Suppurative | |
Iliac, Pigmentation | 1 1 |
Inguinal, Hyperplasia, Lymphoid | 3 2 |
Inguinal, Pigmentation | 1 1 |
Renal, Hyperplasia, Lymphoid | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + I M + + + + + M M|
Atrophy | 4 |
Edema | |
Hyperplasia, Lymphoid | 1 2 2 1 2 1 3 |
Pigmentation | 2 1 1 2 2 1 1 2 2 1 2 1 2 2 1 2 1 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M M + + + M + + + + + + + + + + + M +|
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + M + + + + + + + +|
Congestion | 2 2 3 3 2 2 3 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + M M M + M + + + M M + M M M + I M M M M +|
Pigmentation | 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 4 1 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M M + + + + + + + + + + + + + + + +|
Atrophy | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + +|
Alopecia | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 4 3 4 4|
Necrosis | |
Prepuce, Inflammation, Suppurative | 4 4 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 6| 7| 7| 7| 7| 1| 5| 7| 7| 5| 7| 6| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 1| 1| 7| 9| 4| 6| 3| 3| 3| 3| 0| 5| 3| 3| 0| 3| 1| 3| 7|
| 8| 6| 7| 9| 9| 8| 2| 2| 6| 4| 1| 9| 8| 9| 8| 9| 5| 7| 9| 8| 1| 8| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Edema | 3 |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pons, Demyelination | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Macrophage | |
Inflammation, Chronic | 1 1 2 1 2 1 1 1 2 3 1 1|
Thrombosis | 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 |
Alveolus, Pigmentation | 1 1 1 2 1 1 1 2 1 1 1 1 1 2 1 1 1 1 2 1 1 2 1 1|
Alveolus, Proteinosis | 1 1 1 2 1 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Degeneration | 2 1 2 |
Olfactory Epithelium, Inflammation, | |
Suppurative | 3 1 |
Respiratory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Inflammation,| |
Suppurative | 1 1 3 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 3 1 |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 3| 6| 7| 7| 7| 7| 1| 5| 7| 7| 5| 7| 6| 7| 6|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 1| 1| 7| 9| 4| 6| 3| 3| 3| 3| 0| 5| 3| 3| 0| 3| 1| 3| 7|
| 8| 6| 7| 9| 9| 8| 2| 2| 6| 4| 1| 9| 8| 9| 8| 9| 5| 7| 9| 8| 1| 8| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Fibrosis | |
Inflammation, Chronic | 4 |
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | |
Mineralization | |
Nephropathy | |
Cortex, Cyst | X |
Pelvis, Dilatation | 2 1 1 |
Pelvis, Inflammation, Chronic Active | |
Pelvis, Inflammation, Suppurative | |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
Concretion | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
Calculus Micro Observation Only | X |
Crystals | |
Hemorrhage | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 4 |
Inflammation | |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 0| 1| 6| 7| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 5| 7| 2| 5| 4| 4| 6| 4| 7| 7| 2|
DAY ON TEST | 2| 3| 4| 1| 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 6| 2| 2| 3| 9| 4| 1| 8| 3| 3| 9|
| 4| 5| 3| 7| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 7| 6| 6| 9| 3| 5| 2| 0| 8| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + A + + + A + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M A + + + + + + + + + + + + M + + + + M + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + M + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M A + + + + + + + + A + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | M A + + + + M + + + A + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M A + + + + M + + + A + + + + + + + + A + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | |
Infarct | 4 4 |
Mixed Cell Focus | |
Thrombosis | X X |
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | |
Hemorrhage | |
Thrombosis | |
Vein, Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + M + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Tooth | + + + |
Dysplasia | 4 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
Bilateral, Hyperplasia | |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 0| 1| 6| 7| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 5| 7| 2| 5| 4| 4| 6| 4| 7| 7| 2|
DAY ON TEST | 2| 3| 4| 1| 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 6| 2| 2| 3| 9| 4| 1| 8| 3| 3| 9|
| 4| 5| 3| 7| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 7| 6| 6| 9| 3| 5| 2| 0| 8| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M M M + + + M + + + + + M M + M M + M M + + + + M|
Cyst | X |
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + I + + + + + + + + + + M|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 1 2 2 1 2 1 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
__________________________________________________________________________|
Penis | + + + + +|
Concretion | 3 |
Hemorrhage | 4|
Inflammation | 3 |
Inflammation, Suppurative | |
Mineralization | 3 |
Necrosis, Chronic | 3|
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Concretion | |
Ectasia | 2 3 2 3 1 3 2|
Hemorrhage | 3 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 2 4 4 4 |
Inflammation, Suppurative | 4 2 2 2 |
Bilateral, Ectasia | 4 2 3 3 3 3 3 3 3 |
Bilateral, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + M + M + + + + M + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2 3 2 2|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 |
Congestion | 2 |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 0| 1| 6| 7| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 5| 7| 2| 5| 4| 4| 6| 4| 7| 7| 2|
DAY ON TEST | 2| 3| 4| 1| 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 6| 2| 2| 3| 9| 4| 1| 8| 3| 3| 9|
| 4| 5| 3| 7| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 7| 6| 6| 9| 3| 5| 2| 0| 8| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + I + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 2 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 2 2 2 |
Iliac, Inflammation, Suppurative | 3|
Iliac, Pigmentation | 1 1 |
Inguinal, Hyperplasia, Lymphoid | 2 3 2 2 2 |
Inguinal, Pigmentation | |
Renal, Hyperplasia, Lymphoid | |
Renal, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M + + + + + + + + + + + + + + M + + + + + + + +|
Atrophy | |
Edema | |
Hyperplasia, Lymphoid | 1 2 2 4 |
Pigmentation | 1 2 2 2 2 1 1 2 2 1 1 1 3 2 2 1 2 1 1 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + M + + + + + + M + + + + + + +|
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M + + M M + + + + + + M M + + + + + M + + + + +|
Congestion | 2 2 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M M + M + M M M M M M M + M M M M I M M + M|
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 2 2 2 3 3|
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Thymus | + I M I + + + + M + I + I + + + + + + + + + + + +|
Atrophy | 4 |
Pigmentation | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + |
Alopecia | 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 4 |
Inflammation, Suppurative | 3 4 4 4 |
Necrosis | 4 |
Prepuce, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 0| 1| 6| 7| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 5| 7| 2| 5| 4| 4| 6| 4| 7| 7| 2|
DAY ON TEST | 2| 3| 4| 1| 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 6| 2| 2| 3| 9| 4| 1| 8| 3| 3| 9|
| 4| 5| 3| 7| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 7| 6| 6| 9| 3| 5| 2| 0| 8| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Edema | 3 |
Subcutaneous Tissue, Fibrosis | 3 |
Subcutaneous Tissue, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pons, Demyelination | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + I + + + + + + + + + + + + M + + M + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Macrophage | |
Inflammation, Chronic | 1 2 1 1 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 |
Alveolus, Pigmentation | 1 1 1 1 1 1 2 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolus, Proteinosis | 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 |
Olfactory Epithelium, Degeneration | |
Olfactory Epithelium, Inflammation, | |
Suppurative | |
Respiratory Epithelium, Degeneration | 2 |
Respiratory Epithelium, Inflammation,| |
Suppurative | 4 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 1 |
Vomeronasal Organ, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 0| 1| 6| 7| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 5| 7| 2| 5| 4| 4| 6| 4| 7| 7| 2|
DAY ON TEST | 2| 3| 4| 1| 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 6| 2| 2| 3| 9| 4| 1| 8| 3| 3| 9|
| 4| 5| 3| 7| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 7| 6| 6| 9| 3| 5| 2| 0| 8| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Fibrosis | 1 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 3 2 |
Inflammation, Suppurative | 3|
Mineralization | 1 |
Nephropathy | 1 |
Cortex, Cyst | |
Pelvis, Dilatation | 2 3 |
Pelvis, Inflammation, Chronic Active | |
Pelvis, Inflammation, Suppurative | |
__________________________________________________________________________|
Urethra | + + +|
Calculus Micro Observation Only | X X X|
Concretion | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Crystals | 1 |
Hemorrhage | 3 |
Inflammation, Chronic | 4 |
Inflammation, Chronic Active | |
Inflammation | 3 |
Inflammation, Suppurative | 4 4|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 6| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 7| 3| 4| 3| 0| 3| 3| 1| 9| 7| 2| 3| 3| 2| 0| 4| | |
| 9| 1| 9| 9| 7| 6| 7| 9| 7| 2| 9| 8| 8| 8| 6| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.25MGM3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + A + + + + A + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + A A | 61 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M M + + + + + + + A + + + + A A | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + A + + + + A A | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + A + + + + A + + + + A A | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + A + + + + A + + + + A A | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M A + + + A + + + + A + + + + A A | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 67 |
Angiectasis | | 1 2.0|
Basophilic Focus | 2 | 2 2.0|
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | | 1 |
Infarct | 4 4 4 | 6 3.8|
Mixed Cell Focus | | 1 |
Thrombosis | | 3 |
Hepatocyte, Hyperplasia | | 1 2.0|
Hepatocyte, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Hemorrhage | | 1 3.0|
Thrombosis | | 1 |
Vein, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + M | 65 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A A | 63 |
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + A A | 63 |
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 5 |
Dysplasia | | 4 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 67 |
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 6| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 7| 3| 4| 3| 0| 3| 3| 1| 9| 7| 2| 3| 3| 2| 0| 4| | |
| 9| 1| 9| 9| 7| 6| 7| 9| 7| 2| 9| 8| 8| 8| 6| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.25MGM3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 5 1.4|
Bilateral, Hyperplasia | | 1 2.0|
Spindle Cell, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + M | 64 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + M + + + + + + | 48 |
Cyst | | 1 |
Hyperplasia, Cystic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + | 62 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 67 |
Hyperplasia, Cystic | 1 1 1 2 2 1 1 1 | 27 1.6|
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + | 67 |
Granuloma Sperm | | 1 4.0|
__________________________________________________________________________|____________|
Penis | + + + | 11 |
Concretion | 2 4 | 5 3.4|
Hemorrhage | | 1 4.0|
Inflammation | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Mineralization | | 1 3.0|
Necrosis, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + | 66 |
Concretion | | 1 1.0|
Ectasia | 3 2 3 | 17 2.4|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | 2 3 2 | 7 2.4|
Inflammation, Chronic Active | 2 4 4 2 | 12 3.2|
Inflammation, Suppurative | 4 3 2 | 8 2.8|
Bilateral, Ectasia | 2 2 3 3 2 3 3 3 2 3 3 2 | 34 3.0|
Bilateral, Inflammation, Chronic | | |
Active | | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + M | 61 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 6| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 7| 3| 4| 3| 0| 3| 3| 1| 9| 7| 2| 3| 3| 2| 0| 4| | |
| 9| 1| 9| 9| 7| 6| 7| 9| 7| 2| 9| 8| 8| 8| 6| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.25MGM3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Suppurative | | 2 2.5|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + A | 66 |
Dilatation | 2 | 8 2.8|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + | 66 |
Atrophy | | 3 3.0|
Congestion | | 1 2.0|
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 66 |
Myeloid Cell, Hyperplasia | 4 4 3 3 3 3 | 13 3.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 18 |
Iliac, Hyperplasia, Lymphoid | 4 3 3 3 | 8 2.6|
Iliac, Inflammation, Suppurative | | 1 3.0|
Iliac, Pigmentation | | 4 1.0|
Inguinal, Hyperplasia, Lymphoid | 3 3 | 9 2.4|
Inguinal, Pigmentation | | 2 1.0|
Renal, Hyperplasia, Lymphoid | 3 2 | 2 2.5|
Renal, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + + M + M + + + + + + | 56 |
Atrophy | | 1 4.0|
Edema | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 1 2 2 1 2 2 | 18 1.8|
Pigmentation | 2 1 1 1 2 2 1 1 2 2 2 2 1 2 | 55 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M + + + + M + + + + + + | 57 |
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + M + + + + + M | 55 |
Congestion | 2 3 3 | 13 2.4|
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Lymphoid | 3 2 | 4 2.3|
Inflammation, Suppurative | 4 | 1 4.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + + M M M + M M M M M + M M M | 19 |
Pigmentation | | 3 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 67 |
Angiectasis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 6| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 7| 3| 4| 3| 0| 3| 3| 1| 9| 7| 2| 3| 3| 2| 0| 4| | |
| 9| 1| 9| 9| 7| 6| 7| 9| 7| 2| 9| 8| 8| 8| 6| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.25MGM3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 3 3 2 2 2 | 14 2.4|
Hyperplasia, Lymphoid | 2 3 | 5 2.6|
__________________________________________________________________________|____________|
Thymus | M + M + + + + + + I + I + + M + M | 53 |
Atrophy | | 1 4.0|
Pigmentation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 23 |
Alopecia | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 3 | 2 3.5|
Inflammation, Suppurative | 2 2 | 11 3.3|
Necrosis | 4 | 2 4.0|
Prepuce, Inflammation, Suppurative | 3 4 3 | 5 3.6|
Subcutaneous Tissue, Edema | | 2 3.0|
Subcutaneous Tissue, Fibrosis | | 1 3.0|
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 67 |
Fracture Healed | | 1 |
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 67 |
Pons, Demyelination | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + | 64 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 67 |
Hemorrhage | | 1 1.0|
Hyperplasia, Macrophage | 4 | 1 4.0|
Inflammation, Chronic | 2 2 1 1 | 21 1.4|
Thrombosis | | 2 1.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 | 24 1.0|
Alveolus, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 65 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 6| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 7| 3| 4| 3| 0| 3| 3| 1| 9| 7| 2| 3| 3| 2| 0| 4| | |
| 9| 1| 9| 9| 7| 6| 7| 9| 7| 2| 9| 8| 8| 8| 6| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.25MGM3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Proteinosis | 1 | 12 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + A + + + + + + | 66 |
Inflammation, Suppurative | | 2 1.5|
Olfactory Epithelium, Degeneration | 2 | 4 1.8|
Olfactory Epithelium, Inflammation, | | |
Suppurative | | 2 2.0|
Respiratory Epithelium, Degeneration | 2 | 3 1.7|
Respiratory Epithelium, Inflammation,| | |
Suppurative | | 9 1.6|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 7 1.6|
Vomeronasal Organ, Inflammation, | | |
Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 67 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 67 |
Fibrosis | | 1 1.0|
Inflammation, Chronic | | 2 3.0|
Inflammation, Chronic Active | 3 4 4 | 6 2.8|
Inflammation, Suppurative | | 1 3.0|
Mineralization | | 1 1.0|
Nephropathy | | 1 1.0|
Cortex, Cyst | | 1 |
Pelvis, Dilatation | 2 | 6 1.8|
Pelvis, Inflammation, Chronic Active | 2 | 1 2.0|
Pelvis, Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urethra | + | 4 |
Calculus Micro Observation Only | | 3 |
Concretion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + A A | 63 |
Calculus Micro Observation Only | X | 3 |
Crystals | | 1 1.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
Inflammation, Chronic Active | 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 6| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 7| 3| 4| 3| 0| 3| 3| 1| 9| 7| 2| 3| 3| 2| 0| 4| | |
| 9| 1| 9| 9| 7| 6| 7| 9| 7| 2| 9| 8| 8| 8| 6| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.25MGM3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation | | 1 3.0|
Inflammation, Suppurative | 3 4 | 5 3.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 6| 7| 7| 7| 4| 7| 5| 6|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 9| 3| 3| 3| 8| 3| 8| 8|
| 3| 6| 9| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 4| 8| 0| 9| 9| 8| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + + + + A + M + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 |
Clear Cell Focus | |
Congestion | 2 |
Cyst | |
Infarct | |
Inflammation, Suppurative | 2 |
Mixed Cell Focus | |
Thrombosis | X |
Bile Duct, Cyst | |
Hepatocyte, Cytomegaly | 1|
Hepatocyte, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 4 |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ventricle, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | |
Hyperplasia | 1 3 2 |
Bilateral, Spindle Cell, Hyperplasia | |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 6| 7| 7| 7| 4| 7| 5| 6|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 9| 3| 3| 3| 8| 3| 8| 8|
| 3| 6| 9| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 4| 8| 0| 9| 9| 8| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 1 1 3 1 2 2 1 |
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Inflammation, Suppurative | |
Necrosis, Chronic | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Penis | + + + +|
Concretion | 4 4 1 2|
Hemorrhage | 3 |
Inflammation, Suppurative | |
Necrosis, Chronic | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
Ectasia | 3 3 3 3 2 3 3 3 3 4 4 |
Inflammation, Chronic | 2 2 4 2 4 |
Inflammation, Chronic Active | 2 3 3 |
Inflammation, Suppurative | 3 3 4 2 |
Bilateral, Ectasia | 3 3 3 3 1 3 2 3 2 3 4 3 3|
Bilateral, Inflammation, Chronic | |
Active | |
Bilateral, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + M + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2 2 3|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 3 2 3 3 3 3 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 6| 7| 7| 7| 4| 7| 5| 6|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 9| 3| 3| 3| 8| 3| 8| 8|
| 3| 6| 9| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 4| 8| 0| 9| 9| 8| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hyperplasia, Lymphoid | 2 4 3 4 3 3 3 |
Iliac, Pigmentation | 2 |
Inguinal, Hyperplasia, Lymphoid | 4 2 3 3 |
Pancreatic, Hyperplasia, Lymphoid | 4 |
Pancreatic, Inflammation, | |
Granulomatous | 4 |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 1 1 2 3 2 3 3 2 2 2 1 3 1 2|
Inflammation, Chronic Active | 3 |
Pigmentation | 2 2 1 2 2 2 2 2 1 2 1 2 2 1 2 2 2 2 2 1 2 2 1 2 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M + + + M M + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 3 2 4 1 1 |
Hyperplasia, Lymphoid | 4 3 2 |
Hyperplasia, Macrophage | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M M + M M + M M + M I M I + + M + M + M M M|
Inflammation, Chronic | 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 2 2 2 3 1|
Hyperplasia, Lymphoid | 1 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + I + + M + + + + I M + + + + M + +|
Cyst | |
Inflammation, Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + +|
Inflammation, Suppurative | 4 3 4 4 4 4 4|
Necrosis | 4 |
Prepuce, Inflammation, Chronic Active| |
Prepuce, Inflammation, Suppurative | 4|
Prepuce, Necrosis | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 6| 7| 7| 7| 4| 7| 5| 6|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 9| 3| 3| 3| 8| 3| 8| 8|
| 3| 6| 9| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 4| 8| 0| 9| 9| 8| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Developmental Malformation | |
Hyperostosis | 2 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + I + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Chronic | 1 3 1 2 2 2 1 1 2 2 1 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Alveolus, Pigmentation | 2 2 1 2 2 2 2 1 2 2 1 2 2 2 1 2 2 2 2 1 2 2 2 2 2|
Alveolus, Proteinosis | 3 1 1 1 1 1|
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Olfactory Epithelium, Degeneration | 2 |
Respiratory Epithelium, Degeneration | 3 1 |
Respiratory Epithelium, Inflammation,| |
Suppurative | 3 2 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 4 2 4 |
Necrosis | |
Nephropathy | 1 3 |
Cortex, Cyst | |
Cortex, Inflammation, Chronic | 1|
Pelvis, Dilatation | 2 2 |
Pelvis, Inflammation, Chronic | |
Renal Tubule, Mineralization | 1 1 |
__________________________________________________________________________|
Ureter | + + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Urethra | + + + |
Calculus Micro Observation Only | X X |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 6| 7| 7| 7| 4| 7| 5| 6|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 9| 3| 3| 3| 8| 3| 8| 8|
| 3| 6| 9| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 4| 8| 0| 9| 9| 8| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Concretion | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 3 4 |
Transitional Epithelium, Metaplasia, | |
Squamous | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 2| 3| 5| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 8| 3| 4| 6| 5| 3| 3|
| 9| 9| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 2| 7| 5| 8| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + A + A + + + + + + + + + + + + + M + + +|
Necrosis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M M + A + + + + + + + + I M + + + + A A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + M + + + + + + + + + + + + A A + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + A + A + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + A + A + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + A + A + + + M + + + + + + + + A A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Clear Cell Focus | 1 |
Congestion | |
Cyst | |
Infarct | 4 |
Inflammation, Suppurative | |
Mixed Cell Focus | |
Thrombosis | |
Bile Duct, Cyst | X |
Hepatocyte, Cytomegaly | |
Hepatocyte, Necrosis | 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Tooth | +|
Dysplasia | |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 1 |
Bilateral, Spindle Cell, Hyperplasia | 2 |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 2| 3| 5| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 8| 3| 4| 6| 5| 3| 3|
| 9| 9| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 2| 7| 5| 8| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + M M + M M + + + M + + + + + + + + + + M M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 3 2 2 1 1 2 2 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Inflammation, Suppurative | 2 |
Necrosis, Chronic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Penis | + |
Concretion | 4 |
Hemorrhage | |
Inflammation, Suppurative | |
Necrosis, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Ectasia | 3 2 4 4 4 3 2 4 2|
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 3 |
Inflammation, Suppurative | 4 4 3 3 4 4 4 |
Bilateral, Ectasia | 3 3 3 3 3 4 3 3 3 3 3 4 3 2 |
Bilateral, Inflammation, Chronic | |
Active | 2 |
Bilateral, Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + M + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 2 2 4 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 2 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 2| 3| 5| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 8| 3| 4| 6| 5| 3| 3|
| 9| 9| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 2| 7| 5| 8| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hyperplasia, Lymphoid | 3 3 |
Iliac, Pigmentation | 1 1 |
Inguinal, Hyperplasia, Lymphoid | 4 1 2 3 |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Inflammation, | |
Granulomatous | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + I + + + M + + + + + + + + + + M + + M + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 2 2 3 2 1 3 2|
Inflammation, Chronic Active | |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + M M M + +|
Congestion | 3 2 |
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Macrophage | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + + M M M M + M + M + M M M + M + M M M + M|
Inflammation, Chronic | |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 1 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Thymus | + + M + + I + + + + + + + + + + + + + + + + M + +|
Cyst | |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + M + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + |
Inflammation, Suppurative | 4 4 4 4 |
Necrosis | |
Prepuce, Inflammation, Chronic Active| |
Prepuce, Inflammation, Suppurative | 4 4 |
Prepuce, Necrosis | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 2| 3| 5| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 8| 3| 4| 6| 5| 3| 3|
| 9| 9| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 2| 7| 5| 8| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Developmental Malformation | X |
Hyperostosis | 1 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 1 1 2 1 2 1 2 1 2 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 4 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolus, Pigmentation | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 1 1 1 2 2|
Alveolus, Proteinosis | 1 1 2 2 1 1 1 1 3 |
Pleura, Fibrosis | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Degeneration | 1|
Respiratory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Inflammation,| |
Suppurative | 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Necrosis | |
Nephropathy | 4 |
Cortex, Cyst | X X |
Cortex, Inflammation, Chronic | |
Pelvis, Dilatation | 3 1 4 3 2 |
Pelvis, Inflammation, Chronic | |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Ureter | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Urethra | + + |
Calculus Micro Observation Only | X X |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 5| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 2| 3| 5| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 8| 3| 4| 6| 5| 3| 3|
| 9| 9| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 2| 7| 5| 8| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Concretion | |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Transitional Epithelium, Metaplasia, | |
Squamous | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4| | |
DAY ON TEST | 4| 1| 7| 0| 3| 6| 3| 6| 6| 2| 3| 8| 3| 3| 1| 8| | |
| 9| 2| 9| 9| 8| 0| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
2.5MG/M3 | 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + + + + + + + + A | 57 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + M + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + M + M + + + + + + I + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A + + + + + + + + + + + A | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A + + + + + + + + + + + A | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + + + + + + + + + A | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 66 |
Basophilic Focus | | 3 1.0|
Clear Cell Focus | | 1 1.0|
Congestion | | 1 2.0|
Cyst | X | 1 |
Infarct | | 1 4.0|
Inflammation, Suppurative | | 1 2.0|
Mixed Cell Focus | X | 1 |
Thrombosis | | 1 |
Bile Duct, Cyst | | 1 |
Hepatocyte, Cytomegaly | | 1 1.0|
Hepatocyte, Necrosis | 1 | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + | 65 |
Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + | 65 |
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + | 4 |
Dysplasia | | 1 4.0|
Peridontal Tissue, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + | 66 |
Ventricle, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4| | |
DAY ON TEST | 4| 1| 7| 0| 3| 6| 3| 6| 6| 2| 3| 8| 3| 3| 1| 8| | |
| 9| 2| 9| 9| 8| 0| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
2.5MG/M3 | 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | X | 1 |
Hyperplasia | 1 | 6 1.5|
Bilateral, Spindle Cell, Hyperplasia | | 1 2.0|
Spindle Cell, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + | 66 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + M + + + | 63 |
Pars Distalis, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + | 66 |
Hyperplasia, Cystic | 2 1 1 1 1 2 | 25 1.6|
Inflammation, Suppurative | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Inflammation, Suppurative | | 1 2.0|
Necrosis, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + | 66 |
Granuloma Sperm | 4 | 1 4.0|
__________________________________________________________________________|____________|
Penis | + + | 7 |
Concretion | | 5 3.0|
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
Necrosis, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + | 66 |
Atrophy | | 4 2.3|
Ectasia | 4 3 4 2 3 | 25 3.1|
Inflammation, Chronic | | 5 2.8|
Inflammation, Chronic Active | 4 4 | 7 3.0|
Inflammation, Suppurative | 4 3 | 13 3.5|
Bilateral, Ectasia | 3 3 4 3 3 3 3 3 2 3 | 37 2.9|
Bilateral, Inflammation, Chronic | | |
Active | | 1 2.0|
Bilateral, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + | 63 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4| | |
DAY ON TEST | 4| 1| 7| 0| 3| 6| 3| 6| 6| 2| 3| 8| 3| 3| 1| 8| | |
| 9| 2| 9| 9| 8| 0| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
2.5MG/M3 | 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + | 66 |
Dilatation | 3 3 | 11 2.7|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + | 66 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + | 66 |
Myeloid Cell, Hyperplasia | 3 4 2 | 15 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 20 |
Iliac, Hyperplasia, Lymphoid | 4 3 | 11 3.2|
Iliac, Pigmentation | | 3 1.3|
Inguinal, Hyperplasia, Lymphoid | 3 3 2 | 11 2.7|
Pancreatic, Hyperplasia, Lymphoid | | 1 4.0|
Pancreatic, Inflammation, | | |
Granulomatous | | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + I + + | 61 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 2 2 2 | 28 2.0|
Inflammation, Chronic Active | | 1 3.0|
Pigmentation | 2 2 2 2 2 2 2 2 2 1 2 1 1 2 1 | 61 1.9|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + | 63 |
Hyperplasia, Lymphoid | | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + I + + + + | 56 |
Congestion | 3 2 2 | 12 2.3|
Hyperplasia, Lymphoid | 3 | 5 3.2|
Hyperplasia, Macrophage | 3 | 1 3.0|
Inflammation, Suppurative | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M + M + + M + M M I M M M | 21 |
Inflammation, Chronic | | 1 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + | 66 |
Hematopoietic Cell Proliferation | 4 2 1 | 13 2.2|
Hyperplasia, Lymphoid | 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Thymus | M M + + M + M + + + + + + + M + | 52 |
Cyst | X | 1 |
Inflammation, Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4| | |
DAY ON TEST | 4| 1| 7| 0| 3| 6| 3| 6| 6| 2| 3| 8| 3| 3| 1| 8| | |
| 9| 2| 9| 9| 8| 0| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
2.5MG/M3 | 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + | 63 |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 24 |
Inflammation, Suppurative | 4 4 4 4 4 | 16 3.9|
Necrosis | | 1 4.0|
Prepuce, Inflammation, Chronic Active| 3 | 1 3.0|
Prepuce, Inflammation, Suppurative | | 3 4.0|
Prepuce, Necrosis | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + | 66 |
Developmental Malformation | | 1 |
Hyperostosis | | 4 1.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + | 66 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + M + + + + + + + + + + + + | 64 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + | 66 |
Hemorrhage | | 2 1.5|
Inflammation, Chronic | 1 1 1 1 1 3 1 | 34 1.4|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 3.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 | 40 1.0|
Alveolus, Pigmentation | 2 1 1 1 2 1 2 2 1 2 2 1 2 2 2 1 | 66 1.7|
Alveolus, Proteinosis | 2 2 2 1 2 1 1 | 22 1.5|
Pleura, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 66 |
Inflammation, Suppurative | | 1 3.0|
Olfactory Epithelium, Degeneration | | 2 1.5|
Respiratory Epithelium, Degeneration | 1 | 4 1.5|
Respiratory Epithelium, Inflammation,| | |
Suppurative | 1 | 9 1.3|
Respiratory Epithelium, Metaplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4| | |
DAY ON TEST | 4| 1| 7| 0| 3| 6| 3| 6| 6| 2| 3| 8| 3| 3| 1| 8| | |
| 9| 2| 9| 9| 8| 0| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
2.5MG/M3 | 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Squamous | | 8 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + | 66 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + | 66 |
Inflammation, Suppurative | | 4 3.5|
Necrosis | 1 | 1 1.0|
Nephropathy | | 3 2.7|
Cortex, Cyst | | 2 |
Cortex, Inflammation, Chronic | | 1 1.0|
Pelvis, Dilatation | 3 3 | 9 2.6|
Pelvis, Inflammation, Chronic | 3 | 1 3.0|
Renal Tubule, Mineralization | | 2 1.0|
__________________________________________________________________________|____________|
Ureter | | 2 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Urethra | | 5 |
Calculus Micro Observation Only | | 4 |
Concretion | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + | 65 |
Calculus Micro Observation Only | X | 3 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | 4 | 2 3.5|
Inflammation, Suppurative | | 2 3.5|
Transitional Epithelium, Metaplasia, | | |
Squamous | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 1| 7| 7| 7| 5| 7| 7| 2| 7| 7| 0| 5| 1| 6| 7| 7| 7| 6| 5| 6|
DAY ON TEST | 3| 9| 3| 3| 4| 9| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2| 8| 3| 9| 3| 3| 3| 1| 3| 1|
| 9| 8| 8| 6| 3| 4| 9| 9| 8| 7| 7| 9| 1| 9| 7| 1| 0| 7| 8| 9| 9| 7| 5| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + M + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M M + A + M M + + M + M + M + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Basophilic Focus | X |
Developmental Malformation | |
Eosinophilic Focus | X |
Fatty Change | |
Hematopoietic Cell Proliferation | |
Infarct | 4 |
Hepatocyte, Hyperplasia | 1 1 |
Hepatocyte, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + M + + M + M M + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 1| 7| 7| 7| 5| 7| 7| 2| 7| 7| 0| 5| 1| 6| 7| 7| 7| 6| 5| 6|
DAY ON TEST | 3| 9| 3| 3| 4| 9| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2| 8| 3| 9| 3| 3| 3| 1| 3| 1|
| 9| 8| 8| 6| 3| 4| 9| 9| 8| 7| 7| 9| 1| 9| 7| 1| 0| 7| 8| 9| 9| 7| 5| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 2 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | |
Inflammation, Suppurative | |
Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Penis | + + |
Concretion | 2 |
Inflammation | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Ectasia | 2 4 3 3 3 2 2 |
Inflammation, Chronic | 2 3 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 3 2 2 4 4|
Bilateral, Ectasia | 3 3 3 3 4 4 3 2 3 3 4 3 3 2 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + I + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Dilatation | 2 2|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Bilateral, Atrophy | 3 |
Germinal Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 3|
Myeloid Cell, Inflammation | |
__________________________________________________________________________|
Lymph Node | + + + + + +|
Iliac, Hyperplasia, Lymphoid | 2 3 4|
Iliac, Pigmentation | |
Inguinal, Hyperplasia, Lymphoid | 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 1| 7| 7| 7| 5| 7| 7| 2| 7| 7| 0| 5| 1| 6| 7| 7| 7| 6| 5| 6|
DAY ON TEST | 3| 9| 3| 3| 4| 9| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2| 8| 3| 9| 3| 3| 3| 1| 3| 1|
| 9| 8| 8| 6| 3| 4| 9| 9| 8| 7| 7| 9| 1| 9| 7| 1| 0| 7| 8| 9| 9| 7| 5| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + + M + + M + + + + + + + + +|
Congestion | |
Edema | |
Hyperplasia, Lymphoid | 1 2 1 2 2 3 2 1 2 2 2 1 1 |
Pigmentation | 2 2 2 2 2 2 3 2 2 2 3 3 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Congestion | 1 3 2|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mediastinal | I + + + + M M M M + M M M M I M M + + M M M + M +|
Congestion | |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 1 |
Hyperplasia, Lymphoid | 2 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + +|
Alopecia | |
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | 4 |
Inflammation, Suppurative | 4 4 4 2 |
Necrosis | 4 |
Prepuce, Inflammation | 4|
Prepuce, Inflammation, Suppurative | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + I + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 1| 7| 7| 7| 5| 7| 7| 2| 7| 7| 0| 5| 1| 6| 7| 7| 7| 6| 5| 6|
DAY ON TEST | 3| 9| 3| 3| 4| 9| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2| 8| 3| 9| 3| 3| 3| 1| 3| 1|
| 9| 8| 8| 6| 3| 4| 9| 9| 8| 7| 7| 9| 1| 9| 7| 1| 0| 7| 8| 9| 9| 7| 5| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 1 |
Fibrosis | 1 |
Inflammation, Chronic | 2 1 1 1 1 1 1 2 3 1 1 2 1 1 2 3 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolus, Pigmentation | 3 2 3 2 2 1 2 3 2 2 3 3 1 2 3 2 1 2 2 2 3 1 2 3|
Alveolus, Proteinosis | 1 1 1 1 2 3 2 1 2 2 1 1 1 3 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration | |
Respiratory Epithelium, Degeneration | |
Respiratory Epithelium, Inflammation,| |
Suppurative | 1 1 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Nephropathy | 1 |
Pelvis, Dilatation | 1 1 |
Pelvis, Hyperplasia, Squamous | |
Pelvis, Inflammation, Chronic Active | |
Pelvis, Inflammation, Suppurative | |
__________________________________________________________________________|
Ureter | + |
Concretion | 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Urethra | + + + + +|
Calculus Micro Observation Only | X X|
Concretion | 4 4 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 4| 7| 4| 4| 7| 7| 6| 2| 6| 4| 6| 7| 6| 5| 7| 4| 5| 7| 7| 5|
DAY ON TEST | 3| 4| 0| 1| 9| 8| 3| 5| 2| 2| 0| 9| 7| 5| 2| 0| 3| 7| 8| 3| 3| 7| 2| 3| 0|
| 7| 1| 6| 3| 9| 9| 7| 9| 8| 6| 4| 7| 1| 9| 2| 1| 8| 0| 0| 7| 1| 4| 6| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 0| 1| 2| 3| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + A + + M + + A A + + + + + + + + + A|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + A A A + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + M + + + + + M A A A + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + A + + + + A A A + + + + + + + + + A|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + A M + A + + A + + + + A A A + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + A + + A + + + + A A A + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + A + + A + + + + A A A + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Basophilic Focus | |
Developmental Malformation | |
Eosinophilic Focus | |
Fatty Change | 3 |
Hematopoietic Cell Proliferation | |
Infarct | 4 4 3 |
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | 1 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 4| 7| 4| 4| 7| 7| 6| 2| 6| 4| 6| 7| 6| 5| 7| 4| 5| 7| 7| 5|
DAY ON TEST | 3| 4| 0| 1| 9| 8| 3| 5| 2| 2| 0| 9| 7| 5| 2| 0| 3| 7| 8| 3| 3| 7| 2| 3| 0|
| 7| 1| 6| 3| 9| 9| 7| 9| 8| 6| 4| 7| 1| 9| 2| 1| 8| 0| 0| 7| 1| 4| 6| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 0| 1| 2| 3| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 3 2 1 2 2 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | |
Inflammation, Suppurative | |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 3 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Penis | + + + + + + + + |
Concretion | 4 1 3 1 |
Inflammation | |
Inflammation, Suppurative | 4 3 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 3 3 3 2 4 2 3 2 2 |
Inflammation, Chronic | 4 3 3 |
Inflammation, Chronic Active | 3 4 |
Inflammation, Suppurative | 4 4 4 4 |
Bilateral, Ectasia | 3 4 3 4 3 3 4 4 3 4 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + M + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Dilatation | 2 3 2 3 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Bilateral, Atrophy | |
Germinal Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +|
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 3 2 3 3 2 4 3|
Myeloid Cell, Inflammation | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 4 4 3 2|
Iliac, Pigmentation | 1 1|
Inguinal, Hyperplasia, Lymphoid | 2 2 4 3 2|
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 4| 7| 4| 4| 7| 7| 6| 2| 6| 4| 6| 7| 6| 5| 7| 4| 5| 7| 7| 5|
DAY ON TEST | 3| 4| 0| 1| 9| 8| 3| 5| 2| 2| 0| 9| 7| 5| 2| 0| 3| 7| 8| 3| 3| 7| 2| 3| 0|
| 7| 1| 6| 3| 9| 9| 7| 9| 8| 6| 4| 7| 1| 9| 2| 1| 8| 0| 0| 7| 1| 4| 6| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 0| 1| 2| 3| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + A + + + + + + + + + +|
Congestion | 2 |
Edema | 2|
Hyperplasia, Lymphoid | 2 3 2 2 2 1 1 1 1 1 2 |
Pigmentation | 2 1 2 2 2 2 2 2 2 2 1 1 2 3 3 2 1 2 2 2 2 3 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M M + + + + M + + + + + A + + + + + M + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + M M + + + + + + + + + M|
Congestion | 3 3 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M I M + + M + + + M M M + M M M + M M + M M M|
Congestion | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 3|
Hyperplasia, Lymphoid | 2 |
Thrombosis | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + I + + M + M|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + +|
Alopecia | |
Cyst Epithelial Inclusion | X |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 4 4 4 4 4 4|
Necrosis | |
Prepuce, Inflammation | |
Prepuce, Inflammation, Suppurative | 4 4 4 |
Subcutaneous Tissue, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture Healed | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | M + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 4| 7| 4| 4| 7| 7| 6| 2| 6| 4| 6| 7| 6| 5| 7| 4| 5| 7| 7| 5|
DAY ON TEST | 3| 4| 0| 1| 9| 8| 3| 5| 2| 2| 0| 9| 7| 5| 2| 0| 3| 7| 8| 3| 3| 7| 2| 3| 0|
| 7| 1| 6| 3| 9| 9| 7| 9| 8| 6| 4| 7| 1| 9| 2| 1| 8| 0| 0| 7| 1| 4| 6| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 0| 1| 2| 3| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | |
Fibrosis | |
Inflammation, Chronic | 2 2 2 2 1 2 1 2 2 3 1 1 1 1 2 2 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 |
Alveolus, Pigmentation | 3 2 3 3 1 2 2 2 1 3 3 3 2 2 2 2 2 2 2 3 1 2 2 2 2|
Alveolus, Proteinosis | 1 4 3 1 1 2 3 1 4 1 1 1 2 3 2 2|
__________________________________________________________________________|
Nose | + + + + + + + A + + + + + + A + + + + + + + + + +|
Olfactory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Degeneration | |
Respiratory Epithelium, Inflammation,| |
Suppurative | 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 3 4|
Nephropathy | |
Pelvis, Dilatation | 2 2 |
Pelvis, Hyperplasia, Squamous | 2 |
Pelvis, Inflammation, Chronic Active | 2 |
Pelvis, Inflammation, Suppurative | |
__________________________________________________________________________|
Ureter | +|
Concretion | |
Inflammation, Chronic Active | 4|
Inflammation, Suppurative | |
__________________________________________________________________________|
Urethra | + + + + + |
Calculus Micro Observation Only | X X X X X |
Concretion | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | X |
Inflammation, Chronic Active | 2|
Inflammation, Suppurative | 4 4 |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 6| | |
DAY ON TEST | 7| 3| 7| 5| 7| 2| 5| 3| 9| 3| 3| 9| 1| 3| 3| 1| 1| 3| 1| | |
| 1| 7| 0| 9| 6| 4| 9| 9| 7| 7| 9| 8| 6| 7| 9| 7| 4| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5.0MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + A + + + + M + + + + + + + | 58 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + | 62 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + A M + M + + + + M + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + + + M + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + M + + A + + + + + + + + + M + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + | 69 |
Abscess | | 1 4.0|
Basophilic Focus | | 1 |
Developmental Malformation | X | 1 |
Eosinophilic Focus | | 1 |
Fatty Change | | 1 3.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Infarct | | 4 3.8|
Hepatocyte, Hyperplasia | | 2 1.0|
Hepatocyte, Necrosis | 1 | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + | 68 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + | 67 |
Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + | 67 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Dysplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 69 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + | 69 |
Cyst | X | 1 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 6| | |
DAY ON TEST | 7| 3| 7| 5| 7| 2| 5| 3| 9| 3| 3| 9| 1| 3| 3| 1| 1| 3| 1| | |
| 1| 7| 0| 9| 6| 4| 9| 9| 7| 7| 9| 8| 6| 7| 9| 7| 4| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5.0MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + | 68 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + + M + + + + + M + + M | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + I + + + + + + + + + + + + + + + M + | 66 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia, Cystic | 2 2 1 1 2 1 1 4 | 27 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 4 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + M + + + + + + + + + + + + + | 68 |
Inflammation, Chronic | | 2 3.5|
Inflammation, Chronic Active | | 1 1.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Penis | + + + | 13 |
Concretion | | 5 2.2|
Inflammation | 2 | 1 2.0|
Inflammation, Suppurative | 3 3 | 6 3.2|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + | 69 |
Atrophy | | 2 3.5|
Ectasia | 3 3 3 2 | 20 2.7|
Inflammation, Chronic | 1 2 3 | 9 2.6|
Inflammation, Chronic Active | | 2 3.5|
Inflammation, Suppurative | 4 4 | 11 3.5|
Bilateral, Ectasia | 3 3 2 3 4 3 4 4 3 3 3 2 3 | 41 3.2|
__________________________________________________________________________|____________|
Prostate | + + + + + M + + + + + + + + + M + + + | 65 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + | 69 |
Cyst | X | 1 |
Dilatation | 3 3 | 10 2.4|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + | 69 |
Atrophy | 3 | 1 3.0|
Bilateral, Atrophy | | 1 3.0|
Germinal Epithelium, Degeneration | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 6| | |
DAY ON TEST | 7| 3| 7| 5| 7| 2| 5| 3| 9| 3| 3| 9| 1| 3| 3| 1| 1| 3| 1| | |
| 1| 7| 0| 9| 6| 4| 9| 9| 7| 7| 9| 8| 6| 7| 9| 7| 4| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5.0MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + | 68 |
Erythroid Cell, Hyperplasia | 4 | 1 4.0|
Myeloid Cell, Hyperplasia | 3 3 3 2 3 | 13 2.8|
Myeloid Cell, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 16 |
Iliac, Hyperplasia, Lymphoid | 3 | 8 3.1|
Iliac, Pigmentation | | 2 1.0|
Inguinal, Hyperplasia, Lymphoid | 4 | 9 2.8|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + M + + I | 62 |
Congestion | | 1 2.0|
Edema | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 3 3 2 1 2 3 1 | 33 1.8|
Pigmentation | 2 2 2 2 3 1 2 2 2 2 2 2 2 2 3 2 3 | 60 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + M | 60 |
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + | 63 |
Congestion | 3 | 6 2.5|
Hematopoietic Cell Proliferation | 2 1 | 3 1.7|
Hyperplasia, Lymphoid | 2 | 3 1.7|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + I + M + M + + M I I M M M + M M + M | 25 |
Congestion | 2 | 2 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + | 69 |
Hematopoietic Cell Proliferation | 4 3 3 3 3 4 2 | 17 2.5|
Hyperplasia, Lymphoid | 3 2 | 4 2.3|
Thrombosis | X | 2 |
__________________________________________________________________________|____________|
Thymus | M M + M M M + + I + + + + + + + + M + | 58 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 27 |
Alopecia | 2 | 1 2.0|
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic Active | | 1 4.0|
Inflammation, Suppurative | 4 4 4 | 13 3.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 6| | |
DAY ON TEST | 7| 3| 7| 5| 7| 2| 5| 3| 9| 3| 3| 9| 1| 3| 3| 1| 1| 3| 1| | |
| 1| 7| 0| 9| 6| 4| 9| 9| 7| 7| 9| 8| 6| 7| 9| 7| 4| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5.0MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Necrosis | | 1 4.0|
Prepuce, Inflammation | | 1 4.0|
Prepuce, Inflammation, Suppurative | 3 | 4 3.8|
Subcutaneous Tissue, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + I | 68 |
Fracture Healed | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 69 |
Congestion | | 1 1.0|
Fibrosis | | 1 1.0|
Inflammation, Chronic | 2 2 2 1 1 1 1 1 1 1 1 1 2 1 1 | 55 1.4|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 40 1.0|
Alveolus, Pigmentation | 2 2 2 1 2 2 2 2 2 2 3 2 3 2 3 1 2 2 3 | 68 2.1|
Alveolus, Proteinosis | 3 1 2 2 1 1 1 2 1 2 1 3 | 43 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + | 67 |
Olfactory Epithelium, Degeneration | | 1 1.0|
Respiratory Epithelium, Degeneration | 1 | 1 1.0|
Respiratory Epithelium, Inflammation,| | |
Suppurative | 1 | 7 1.1|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + M + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + | 68 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | 4 2 3 1 | 6 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05123-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:50:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 6| 6| | |
DAY ON TEST | 7| 3| 7| 5| 7| 2| 5| 3| 9| 3| 3| 9| 1| 3| 3| 1| 1| 3| 1| | |
| 1| 7| 0| 9| 6| 4| 9| 9| 7| 7| 9| 8| 6| 7| 9| 7| 4| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5.0MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | | 1 1.0|
Pelvis, Dilatation | 2 | 5 1.6|
Pelvis, Hyperplasia, Squamous | | 1 2.0|
Pelvis, Inflammation, Chronic Active | | 1 2.0|
Pelvis, Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ureter | + + | 4 |
Concretion | 3 | 2 2.5|
Inflammation, Chronic Active | | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urethra | + + | 12 |
Calculus Micro Observation Only | X | 8 |
Concretion | 4 | 4 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + | 66 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 1 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | 4 4 | 4 4.0|
Transitional Epithelium, Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------