TDMS Study 05123-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: LITRI NICKEL OXIDE DATE: 05/20/95
EXPERIMENT: 05123 TEST: 06 TIME: 05:42:06
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: Y0-ES-30108 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C00862
PATHOLOGIST: P. HALEY CAS: 1313-99-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: LITRI NICKEL OXIDE DATE: 05/20/95
EXPERIMENT: 05123 TEST: 06 TIME: 05:42:06
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: Y0-ES-30108 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C00862
PATHOLOGIST: P. HALEY CAS: 1313-99-1
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/M3 |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 36 CENSORED DEATHS 4 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 4 162 162 162 290 341 392 430 470 508 |
| 510 512 559 559 559 584 590 599 601 602 |
| 603 607 629 629 643 643 653 660 666 675 |
| 689 694 697 713 713 732 |
| CENSORED DEATHS |
| 77 77 77 78 |
| |
|--------------------------------------------------------------------------------|
| DOSE = O MG/M3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 2 CENSORED DEATHS 16 TERMINAL 2 |
| |
| UNCENSORED DEATHS |
| 593 637 |
| CENSORED DEATHS |
| 77 77 77 77 77 77 199 199 199 199 |
| 199 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.25MGM3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 24 105 135 157 226 290 298 341 442 445 |
| 471 480 493 508 512 539 593 604 610 612 |
| 612 616 626 637 643 644 649 669 675 679 |
| 683 692 694 706 717 726 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.25MGM3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 3 |
| |
| UNCENSORED DEATHS |
| 501 539 557 567 676 717 728 |
| CENSORED DEATHS |
| 199 199 199 199 199 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5MG/M3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 31 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 155 356 463 483 483 489 516 539 539 540 |
| 552 580 603 605 629 648 649 660 660 665 |
| 665 676 676 677 684 696 704 709 712 718 |
| 730 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5MG/M3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 6 CENSORED DEATHS 10 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 245 368 482 539 679 694 |
| CENSORED DEATHS |
| 199 199 199 199 199 458 458 458 458 458 |
| |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5.0MG/M3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 137 194 224 241 271 422 428 459 489 499 |
| 501 527 538 543 559 574 580 597 601 612 |
| 616 635 641 659 659 670 697 698 698 704 |
| 706 713 714 716 726 726 736 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5.0MG/M3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 9 CENSORED DEATHS 10 TERMINAL 1 |
| |
| UNCENSORED DEATHS |
| 21 317 431 571 580 615 670 676 698 |
| CENSORED DEATHS |
| 199 199 199 199 199 458 458 458 458 458 |
| |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 737 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/M3 | 98.3 92.8 92.8 89.2 87.4 83.7 78.3 61.9 49.2 34.6 |
| | |
| | |
|O | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 75.0 50.0 50.0 |
|MG/M3 LUN|TX |
| | |
|1.25MGM3 | 98.3 93.3 91.7 86.7 86.7 80.0 73.3 70.0 55.0 38.3 |
| | |
| | |
|1.25MGM3 | 100.0 100.0 100.0 100.0 100.0 100.0 80.0 60.0 60.0 30.0 |
|LUNGTX | |
| | |
|2.5MG/M3 | 100.0 98.3 98.3 96.7 96.7 91.7 83.3 76.7 65.0 48.3 |
| | |
| | |
|2.5MG/M3 | 100.0 100.0 93.3 93.3 86.7 75.8 65.0 65.0 65.0 43.3 |
|LUNGTX | |
| | |
|5.0MG/M3 | 100.0 98.3 93.3 91.7 90.0 86.7 76.7 68.3 58.3 38.3 |
| | |
| | |
|5.0MG/M3 | 95.0 95.0 95.0 88.2 88.2 81.4 81.4 58.2 46.5 11.6 |
|LUNGTX | |
| | |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/M3 O 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3 5.0MG/M3 5.0MG/M3 |
| MG/M3 LUNG X LUNGTX LUNGTX LUNGTX |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 34.6% 50.0% 38.3% 30.0% 48.3% 43.3% 38.3% 11.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.986N ----- P=0.768N P=0.950N P=0.097N P=0.762N P=0.601N P=0.357 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 534.5 615.0 521.1 612.1 595.5 501.2 559.7 508.8 |
|NATURAL DEATHS (C) | (30.2) (22.0) (32.1) (34.9) (22.2) (71.6) (27.1) (73.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 568.7 322.6 603.8 489.1 663.9 462.0 627.7 430.1 |
|(STANDARD ERROR) | (28.1) (52.5) (24.0) (44.9) (14.6) (46.2) (20.1) (46.2) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/M3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 1 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 29 117 132 357 510 549 559 586 599 618 |
| 622 638 642 688 694 695 728 728 |
| CENSORED DEATHS |
| 14 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 MG/M3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 4 CENSORED DEATHS 10 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 11 24 92 229 |
| CENSORED DEATHS |
| 200 200 200 200 200 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.25MGM3 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 203 317 469 510 566 583 603 609 640 644 |
| 652 676 683 683 690 692 695 711 720 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.25MGM3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 6 CENSORED DEATHS 10 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 46 162 593 597 626 657 |
| CENSORED DEATHS |
| 200 200 200 200 200 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5MG/M3 |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 16 CENSORED DEATHS 1 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 16 19 58 321 326 451 538 570 584 587 |
| 630 640 659 669 670 681 |
| CENSORED DEATHS |
| 315 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5MG/M3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 4 CENSORED DEATHS 10 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 36 566 670 676 |
| CENSORED DEATHS |
| 200 200 200 200 200 459 459 459 459 459 |
| |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5.0MG/M3 |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 70 141 293 426 495 510 533 584 595 602 |
| 619 640 644 670 673 675 684 699 713 720 |
| 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5.0MG/M3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 5 CENSORED DEATHS 10 TERMINAL 5 |
| |
| UNCENSORED DEATHS |
| 469 498 644 658 696 |
| CENSORED DEATHS |
| 200 200 200 200 200 459 459 459 459 459 |
| |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/M3 | 98.3 94.9 94.9 93.2 93.2 93.2 91.5 84.7 78.0 69.5 |
| | |
| | |
|0 | 90.0 85.0 77.9 77.9 77.9 77.9 77.9 77.9 77.9 77.9 |
|MG/M3 LUN|TX |
| | |
|1.25MGM3 | 100.0 100.0 98.3 96.7 96.7 95.0 93.3 88.3 81.7 66.7 |
| | |
| | |
|1.25MGM3 | 95.0 90.0 90.0 90.0 90.0 90.0 90.0 67.5 45.0 45.0 |
|LUNGTX | |
| | |
|2.5MG/M3 | 94.9 94.9 94.9 91.5 91.5 89.7 88.0 82.8 77.7 72.5 |
| | |
| | |
|2.5MG/M3 | 95.0 95.0 95.0 95.0 95.0 95.0 95.0 84.4 84.4 63.3 |
|LUNGTX | |
| | |
|5.0MG/M3 | 98.3 96.6 96.6 94.9 94.9 93.2 88.1 83.1 78.0 64.4 |
| | |
| | |
|5.0MG/M3 | 100.0 100.0 100.0 100.0 100.0 90.0 80.0 80.0 60.0 50.0 |
|LUNGTX | |
| | |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/M3 0 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3 5.0MG/M3 5.0MG/M3 |
| MG/M3 LUNG X LUNGTX LUNGTX LUNGTX |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 69.5% 77.9% 66.7% 45.0% 72.5% 63.3% 64.4% 50.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.747 ----- P=0.956 P=0.201 P=0.943N P=0.998 P=0.696 P=0.541 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 527.3 89.0 603.6 446.8 463.7 487.0 557.7 593.0 |
|NATURAL DEATHS (C) | (51.7) (49.9) (30.7) ( 110) (60.5) ( 152) (40.3) (45.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 656.6 401.3 687.2 444.6 650.0 480.9 668.0 495.3 |
|(STANDARD ERROR) | (22.2) (58.1) (12.7) (50.9) (23.0) (52.4) (17.8) (46.0) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NICKEL OXIDE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/M3 = 1
O MG/M3 LUNGTX = 2
1.25MGM3 = 3
1.25MGM3 LUNGTX = 4
2.5MG/M3 = 5
2.5MG/M3 LUNGTX = 6
5.0MG/M3 = 7
5.0MG/M3 LUNGTX = 8
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 11 83 7 5 6 4 2
| 1 3 3 3 51 7 7 5 5
| 8 3 3 7 7 8 5 5
| 31 3 6 7 1 6 7 55
90 + 13 1 1 77 5 4 5 4
| 3 8 3 6 1 1 3 7 67 5 5
| 1 1 7 7 55
| 8 3 13 71 7 55 85
80 + 3 3 11 74 4 5 5
| 3 31 77 1 5 5
P | 6 3 3 7 7 2 52 5
E | 3 1 771 373 5 5
R 70 + 44881 1133
C | 7 7
E | 6 7 7 5 5
N | 113 337 7
T 60 + 4 1 133 45
| 8 8 1 13 77 5 55
S | 3 36 655
U | 1 1 33 7755
R 50 + 2 1 1133 4 52
V | 8 1133377 55
I | 1 13377
V | 113 33 6
A 40 + 1 144 7
L | 1 3 13
| 88 11
|
30 + 4 4
|
|
| 8 8
20 +
|
|
| 8 8
10 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 53 obs hidden.
NICKEL OXIDE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/M3 = 1
0 MG/M3 LUNGTX = 2
1.25MGM3 = 3
1.25MGM3 LUNGTX = 4
2.5MG/M3 = 5
2.5MG/M3 LUNGTX = 6
5.0MG/M3 = 7
5.0MG/M3 LUNGTX = 8
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 25 164 7 3 8
| 5 1 57 1 1 7 3 7 3 3
| 2 2 64 5 1 4 7 5 1 7 3 3 6
| 55 1 7 5 7 1 1 3 3
P 90 + 2 2 4 5 8 87 5 11 3 4 3
E | 5 1 5 1 713 3
R | 2 2 6 71 1 6
C | 5 7 15 1 3 3
E 80 + 8 44 5 5 5 33
N | 2 1 557311 2
T | 565
| 7531 3 1 5
S 70 + 8 8 7 7 331 1
U | 4 4 733 3
R | 77 7
V | 6 6
I 60 + 8 8
V | 4 4
A |
L |
50 + 8 8
|
| 4 4
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 45 obs hidden.