TDMS Study 05123-05 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
NICKEL OXIDE
NTP Experiment-Test: 05123-05 Report: PEIRPT03
Study Type: CHRONIC Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 001313991
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 58 7 58 7 58 7
Scheduled Sacrifice 5 7 5 7 5 7
Early Deaths
Moribund Sacrifice 27 24 27
Natural Death 5 3 6
Survivors
Terminal Sacrifice 21 26 20
Animals Examined Microscopically 58 7 58 7 58 7
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (57) (58) (58)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Parasite Metazoan 2 (3%) 1 (2%)
Intestine Large, Rectum (57) (58) (57)
Parasite Metazoan 2 (4%) 2 (4%)
Intestine Large, Cecum (57) (58) (58)
Parasite Metazoan 1 (2%)
Liver (58) (1) (58) (58)
Angiectasis 2 (3%) 1 (2%)
Basophilic Focus 26 (45%) 38 (66%) 27 (47%)
Clear Cell Focus 1 (2%)
Congestion 2 (3%) 1 (2%) 3 (5%)
Cyst 1 (2%)
Degeneration, Cystic 1 (2%) 2 (3%)
Eosinophilic Focus 2 (3%) 3 (5%) 3 (5%)
Fatty Change 21 (36%) 18 (31%) 16 (28%)
Fibrosis 1 (2%)
Granuloma 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 7 (12%) 1 (100%) 3 (5%) 9 (16%)
Mixed Cell Focus 1 (2%)
Pigmentation, Bile 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 4 (7%) 3 (5%) 3 (5%)
Hepatocyte, Hyperplasia 4 (7%) 6 (10%) 3 (5%)
Hepatocyte, Necrosis 6 (10%) 7 (12%) 3 (5%)
Portal Vein, Thrombosis 1 (2%)
Pancreas (57) (58) (58)
Atrophy 2 (3%) 1 (2%)
Acinus, Atrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Mineralization 1 (2%)
Stomach, Forestomach (57) (58) (58)
Edema 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%) 4 (7%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Ulcer 3 (5%) 2 (3%)
Stomach, Glandular (57) (58) (58)
Erosion 1 (2%) 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (1) (2)
Aorta, Mineralization 1 (50%)
Aorta, Polyarteritis 1 (100%)
Mesenteric Artery, Polyarteritis 1 (100%)
Mesenteric Artery, Thrombosis 1 (100%)
Vena Cava, Mineralization 1 (50%)
Heart (58) (58) (58)
Atrium, Thrombosis 1 (2%) 1 (2%) 1 (2%)
Vein, Inflammation, Chronic Active 1 (2%)
Ventricle, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58) (58) (58)
Angiectasis 1 (2%) 3 (5%) 3 (5%)
Atrophy 1 (2%)
Congestion 1 (2%) 2 (3%) 2 (3%)
Cyst 1 (2%)
Degeneration 2 (3%)
Degeneration, Fatty 2 (3%) 3 (5%) 5 (9%)
Edema 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Bilateral, Angiectasis 1 (2%)
Adrenal Medulla (56) (57) (57)
Angiectasis 3 (5%) 1 (2%)
Congestion 1 (2%)
Hyperplasia 9 (16%) 12 (21%) 15 (26%)
Islets, Pancreatic (57) (58) (58)
Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Parathyroid Gland (50) (51) (55)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Pituitary Gland (57) (57) (2) (57) (3)
Angiectasis 1 (2%) 1 (2%)
Pars Distalis, Angiectasis 7 (12%) 6 (11%) 6 (11%)
Pars Distalis, Cyst 8 (14%) 8 (14%) 11 (19%)
Pars Distalis, Degeneration 1 (2%)
Pars Distalis, Hyperplasia 9 (16%) 11 (19%) 7 (12%)
Pars Distalis, Hyperplasia, Cystic 1 (2%)
Pars Distalis, Hyperplasia, Diffuse 2 (100%) 3 (100%)
Pars Intermedia, Angiectasis 1 (2%) 1 (2%)
Pars Intermedia, Cyst 1 (2%)
Pars Intermedia, Hypertrophy 1 (2%)
Thyroid Gland (57) (57) (58)
C-Cell, Hyperplasia 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (58) (58) (56)
Atrophy 1 (2%)
Ectasia 5 (9%) 3 (5%) 5 (9%)
Hyperplasia, Cystic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Ovary (58) (58) (58) (2)
Cyst 6 (10%) 7 (12%) 8 (14%) 2 (100%)
Uterus (58) (58) (57)
Cyst 1 (2%)
Dilatation 1 (2%)
Prolapse 1 (2%)
Endometrium, Hyperplasia, Cystic 5 (9%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (57) (58) (58)
Fibrosis 5 (9%) 3 (5%) 3 (5%)
Hyperplasia 14 (25%) 15 (26%) 15 (26%)
Necrosis 1 (2%)
Lymph Node (14) (6) (9)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (17%)
Pigmentation 1 (7%)
Iliac, Hyperplasia, Lymphoid 1 (7%)
Pancreatic, Hyperplasia, Lymphoid 1 (11%)
Pancreatic, Inflammation, Chronic Active 1 (7%)
Popliteal, Pigmentation 1 (7%)
Renal, Congestion 2 (33%)
Renal, Hyperplasia, Lymphoid 1 (11%)
Renal, Pigmentation, Hemosiderin 1 (7%)
Lymph Node, Bronchial (54) (6) (55) (7) (58) (7)
Congestion 2 (4%) 2 (4%) 1 (2%)
Edema 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 5 (9%) 23 (40%) 4 (57%)
Hyperplasia, Macrophage 1 (2%)
Pigmentation 47 (85%) 57 (98%) 7 (100%)
Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mandibular (52) (50) (56)
Congestion 1 (2%)
Hyperplasia, Lymphoid 3 (6%) 2 (4%) 3 (5%)
Pigmentation 2 (4%)
Lymph Node, Mesenteric (56) (58) (58)
Congestion 1 (2%)
Inflammation, Chronic Active 1 (2%)
Pigmentation 4 (7%) 2 (3%)
Lymph Node, Mediastinal (53) (6) (51) (7) (52) (6)
Congestion 1 (2%) 5 (10%) 7 (13%)
Ectasia 1 (2%)
Edema 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 9 (18%) 14 (27%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Pigmentation 37 (73%) 43 (83%) 2 (33%)
Pigmentation, Hemosiderin 1 (2%)
Spleen (58) (58) (58)
Fibrosis 1 (2%) 3 (5%) 3 (5%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infarct 1 (2%) 1 (2%)
Necrosis 1 (2%)
Capsule, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (58) (58)
Hyperplasia, Glandular 1 (2%)
Skin (4) (3) (3)
Inflammation, Suppurative 1 (33%)
Subcutaneous Tissue, Edema 1 (33%)
Subcutaneous Tissue, Fibrosis 1 (33%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58) (58) (58)
Hyperostosis 2 (3%)
Osteopetrosis 4 (7%) 2 (3%)
Femur, Hyperostosis 5 (9%) 2 (3%) 10 (17%)
Skeletal Muscle (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58) (58) (58)
Hemorrhage 1 (2%)
Cerebellum, Compression 1 (2%) 1 (2%)
Cerebrum, Compression 5 (9%) 4 (7%) 3 (5%)
Cerebrum, Ventricle, Dilatation 2 (3%)
Hypothalamus, Compression 2 (3%) 1 (2%) 3 (5%)
Pons, Compression 1 (2%)
Ventricle, Dilatation 2 (3%) 1 (2%) 1 (2%)
Ventricle, Ectasia 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (58) (58) (58)
Inflammation, Chronic 4 (7%) 2 (3%)
Inflammation, Chronic Active 3 (5%) 2 (3%) 2 (3%)
Inflammation, Suppurative 1 (2%) 2 (3%)
Lung (58) (7) (58) (7) (58) (7)
Congestion 1 (2%) 1 (2%)
Hemorrhage 2 (3%)
Inflammation, Chronic 21 (36%) 1 (14%) 56 (97%) 58 (100%) 7 (100%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia, Atypical 1 (2%) 1 (2%) 6 (10%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Alveolar Epithelium, Pigmentation 1 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolus, Pigmentation 57 (98%) 5 (71%) 58 (100%) 7 (100%)
Pleura, Fibrosis 1 (2%)
Nose (58) (7) (58) (7) (57) (7)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Trachea (58) (58) (58)
Inflammation, Chronic Active 2 (3%)
Inflammation, Suppurative 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (2) (6) (1)
Cataract 2 (33%)
Hemorrhage 1 (33%)
Inflammation, Suppurative 1 (33%)
Necrosis 1 (33%)
Synechia 1 (17%)
Bilateral, Cornea, Edema 1 (17%)
Cornea, Degeneration 1 (100%)
Cornea, Edema 2 (33%)
Lens, Cataract 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (7) (58) (7) (58) (7)
Cyst 2 (3%)
Nephropathy 40 (69%) 47 (81%) 40 (69%)
Cortex, Infiltration Cellular, Lymphocyte 1 (14%)
Cortex, Inflammation, Chronic 1 (2%) 1 (2%)
Cortex, Necrosis, Acute 1 (2%)
Pelvis, Dilatation 1 (2%)
Urinary Bladder (57) (58) (58)
Calculus Micro Observation Only 1 (2%) 1 (2%)
Edema 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 58 7
Scheduled Sacrifice 5 6
Early Deaths
Moribund Sacrifice 24 1
Natural Death 3
Survivors
Terminal Sacrifice 26
Animals Examined Microscopically 58 7
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (58) (1)
Parasite Metazoan 5 (9%)
Liver (58) (1)
Angiectasis 1 (2%)
Basophilic Focus 34 (59%)
Degeneration, Cystic 1 (2%)
Eosinophilic Focus 2 (3%)
Fatty Change 15 (26%)
Hepatodiaphragmatic Nodule 4 (7%)
Inflammation, Chronic 1 (2%)
Pigmentation, Bile 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Hepatocyte, Hyperplasia 8 (14%)
Hepatocyte, Necrosis 4 (7%)
Stomach, Forestomach (58) (1)
Hyperkeratosis 3 (5%) 1 (100%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
Tooth (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (58) (1)
Inflammation, Chronic 1 (2%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58) (1)
Congestion 4 (7%)
Degeneration, Fatty 8 (14%)
Edema 1 (2%)
Adrenal Medulla (57) (1)
Angiectasis 1 (2%)
Hyperplasia 22 (39%)
Islets, Pancreatic (58) (1)
Hyperplasia 1 (2%)
Pituitary Gland (58) (2)
Pars Distalis, Angiectasis 5 (9%)
Pars Distalis, Cyst 9 (16%)
Pars Distalis, Hemorrhage 2 (3%)
Pars Distalis, Hyperplasia 12 (21%)
Pars Distalis, Hyperplasia, Diffuse 1 (50%)
Thyroid Gland (58)
C-Cell, Hyperplasia 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (3)
Abscess 1 (33%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (54) (1)
Ectasia 4 (7%)
Duct, Ectasia 1 (2%)
Ovary (58) (1)
Cyst 3 (5%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Bilateral, Cyst 1 (2%)
Uterus (58) (1)
Dilatation 1 (2%)
Endometrium, Hyperplasia, Cystic 7 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (58) (1)
Fibrosis 1 (2%)
Hyperplasia 16 (28%)
Lymph Node (4)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (25%)
Renal, Edema 1 (25%)
Renal, Pigmentation 1 (25%)
Lymph Node, Bronchial (56) (7)
Congestion 2 (4%)
Hyperplasia, Lymphoid 15 (27%) 4 (57%)
Hyperplasia, Macrophage 1 (2%)
Pigmentation 52 (93%) 6 (86%)
Lymph Node, Mandibular (53) (1)
Hyperplasia, Lymphoid 2 (4%) 1 (100%)
Lymph Node, Mesenteric (58) (1)
Hyperplasia, Lymphoid 3 (5%)
Pigmentation 3 (5%)
Lymph Node, Mediastinal (54) (5)
Congestion 1 (2%)
Edema 1 (2%)
Hyperplasia, Lymphoid 17 (31%)
Pigmentation 47 (87%) 3 (60%)
Spleen (58) (1)
Fibrosis 1 (2%)
Hyperplasia 2 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58) (1)
Femur, Hyperostosis 8 (14%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58) (1)
Cerebrum, Compression 5 (9%)
Cerebrum, Ventricle, Dilatation 5 (9%)
Hypothalamus, Compression 5 (9%)
Ventricle, Dilatation 3 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (58) (1)
Inflammation, Chronic 3 (5%)
Lung (58) (7)
Congestion 1 (2%)
Cyst 1 (2%)
Hemorrhage 2 (3%)
Inflammation, Chronic 58 (100%) 7 (100%)
Alveolar Epithelium, Hyperplasia, Atypical 5 (9%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Alveolus, Pigmentation 58 (100%) 7 (100%)
Nose (58) (7)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3)
Cataract 2 (67%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (7)
Nephropathy 42 (72%)
Cortex, Infiltration Cellular, Lymphocyte 1 (14%)
Pelvis, Cyst 1 (14%)
Urinary Bladder (58) (2)
Edema, Focal 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 59 6 58 7 58 7
Scheduled Sacrifice 5 6 5 7 5 7
Early Deaths
Moribund Sacrifice 39 35 32
Natural Death 1 3 6
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 14 15 14
Animals Examined Microscopically 59 6 58 7 58 7
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (59) (58) (58)
Erosion 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%)
Intestine Large, Rectum (59) (58) (57)
Parasite Metazoan 1 (2%) 1 (2%)
Intestine Large, Cecum (59) (58) (57)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Parasite Metazoan 1 (2%)
Ulcer 1 (2%)
Intestine Small, Jejunum (59) (58) (58)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Liver (59) (58) (58) (1)
Angiectasis 1 (2%)
Basophilic Focus 21 (36%) 15 (26%) 22 (38%)
Clear Cell Focus 1 (2%) 1 (2%)
Congestion 1 (2%)
Degeneration, Cystic 16 (27%) 20 (34%) 27 (47%)
Developmental Malformation 1 (2%)
Eosinophilic Focus 3 (5%) 4 (7%) 6 (10%)
Fatty Change 13 (22%) 15 (26%) 20 (34%)
Hepatodiaphragmatic Nodule 4 (7%) 1 (2%) 2 (3%) 1 (100%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Pigmentation, Bile 1 (2%) 1 (2%)
Thrombosis 1 (2%) 1 (2%) 1 (2%)
Thrombosis, Multiple 2 (3%)
Bile Duct, Hyperplasia 17 (29%) 20 (34%) 18 (31%)
Hepatocyte, Hyperplasia 8 (14%) 14 (24%) 9 (16%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Necrosis 8 (14%) 14 (24%) 4 (7%)
Pancreas (59) (58) (58)
Atrophy 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Acinus, Atrophy 5 (8%) 1 (2%) 1 (2%)
Acinus, Fibrosis 1 (2%)
Acinus, Hyperplasia 2 (3%) 1 (2%)
Stomach, Forestomach (59) (58) (58)
Edema 3 (5%)
Hyperkeratosis 1 (2%) 6 (10%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 3 (5%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%) 3 (5%) 3 (5%)
Ulcer, Multiple 2 (3%)
Stomach, Glandular (59) (58) (58)
Erosion 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2) (1)
Aorta, Mineralization 2 (100%) 1 (100%)
Heart (59) (58) (58)
Fibrosis 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 2 (3%)
Atrium, Thrombosis 4 (7%) 6 (10%) 4 (7%)
Epicardium, Degeneration 1 (2%)
Myocardium, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (58) (58)
Angiectasis 2 (3%)
Degeneration, Fatty 2 (3%) 1 (2%) 6 (10%)
Adrenal Medulla (59) (57) (58)
Cyst 1 (2%)
Degeneration, Fatty 1 (2%)
Hyperplasia 25 (42%) 27 (47%) 27 (47%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Islets, Pancreatic (59) (58) (58)
Hyperplasia 3 (5%) 2 (3%)
Parathyroid Gland (54) (55) (54)
Hyperplasia 2 (4%) 2 (4%)
Pituitary Gland (58) (57) (57)
Angiectasis 2 (3%) 3 (5%)
Hyperplasia 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Cyst 2 (3%)
Pars Distalis, Hyperplasia 4 (7%) 3 (5%) 6 (11%)
Pars Distalis, Necrosis 1 (2%)
Pars Distalis, Pigmentation 1 (2%)
Thyroid Gland (59) (58) (57)
Hyperplasia, Cystic 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
C-Cell, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (3) (2) (2)
Developmental Malformation 1 (50%)
Oral, Inflammation, Chronic Active 1 (33%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (4)
Inflammation, Chronic 1 (25%)
Inflammation, Suppurative 2 (50%)
Epididymis (59) (58) (58)
Spermatocele 1 (2%) 2 (3%)
Preputial Gland (59) (58) (58)
Ectasia 2 (3%) 3 (5%) 4 (7%)
Inflammation, Suppurative 3 (5%) 1 (2%)
Bilateral, Ectasia 1 (2%)
Duct, Ectasia 1 (2%)
Prostate (58) (58) (58)
Hyperplasia 1 (2%)
Inflammation, Chronic 3 (5%) 3 (5%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Suppurative 3 (5%) 1 (2%) 4 (7%)
Seminal Vesicle (59) (58) (58)
Atrophy 3 (5%) 3 (5%)
Ectasia 1 (2%) 1 (2%)
Inflammation, Suppurative 2 (3%)
Testes (59) (58) (58)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Atrophy 11 (19%) 7 (12%) 7 (12%)
Hemorrhage 1 (2%)
Bilateral, Atrophy 1 (2%) 2 (3%)
Interstitial Cell, Hyperplasia 8 (14%) 4 (7%) 3 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (58) (58)
Fibrosis 7 (12%) 4 (7%) 5 (9%)
Hyperplasia 24 (41%) 35 (60%) 19 (33%)
Lymph Node (16) (19) (16) (1)
Pigmentation 4 (21%) 1 (100%)
Iliac, Congestion 2 (11%)
Iliac, Ectasia 1 (6%)
Iliac, Hyperplasia, Lymphoid 1 (6%) 1 (5%) 1 (6%)
Iliac, Pigmentation 1 (6%)
Pancreatic, Congestion 1 (5%)
Pancreatic, Hyperplasia, Lymphoid 1 (6%)
Renal, Congestion 2 (11%) 1 (6%)
Renal, Hyperplasia, Lymphoid 1 (6%) 2 (11%) 1 (6%)
Renal, Pigmentation 3 (16%)
Lymph Node, Bronchial (57) (6) (56) (7) (58) (7)
Congestion 1 (2%) 1 (2%)
Congestion, Chronic 1 (17%)
Edema 1 (2%)
Hyperplasia, Lymphoid 1 (17%) 7 (13%) 14 (24%) 7 (100%)
Hyperplasia, Macrophage 1 (2%)
Pigmentation 50 (89%) 56 (97%) 7 (100%)
Lymph Node, Mandibular (54) (56) (55)
Hyperplasia, Lymphoid 5 (9%) 4 (7%) 6 (11%)
Lymph Node, Mesenteric (59) (58) (58)
Congestion 2 (3%)
Edema 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (3%)
Lymph Node, Mediastinal (52) (6) (57) (6) (57) (6)
Congestion 1 (2%) 2 (4%) 1 (17%)
Ectasia 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 5 (10%) 8 (14%) 13 (23%) 3 (50%)
Hyperplasia, Plasma Cell 3 (6%) 2 (4%)
Pigmentation 36 (63%) 47 (82%) 4 (67%)
Spleen (59) (58) (58)
Congestion 1 (2%)
Developmental Malformation 1 (2%) 1 (2%)
Fibrosis 11 (19%) 7 (12%) 15 (26%)
Infarct 4 (7%) 6 (10%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Necrosis 1 (2%) 1 (2%)
Capsule, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (58) (58)
Hyperplasia 1 (2%)
Duct, Ectasia 1 (2%)
Skin (13) (4) (14)
Alopecia 1 (7%)
Cyst Epithelial Inclusion 2 (15%) 2 (50%) 2 (14%)
Hyperkeratosis 1 (8%) 1 (7%)
Necrosis 1 (7%)
Pigmentation 1 (8%)
Epidermis, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59) (58) (58)
Hyperostosis 1 (2%) 2 (3%)
Femur, Hyperostosis 2 (3%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (58) (58)
Cerebellum, Compression 1 (2%) 1 (2%)
Cerebellum, Hemorrhage 2 (3%) 3 (5%)
Cerebellum, Ventricle, Dilatation 1 (2%)
Cerebrum, Compression 5 (9%) 7 (12%)
Cerebrum, Degeneration 1 (2%)
Cerebrum, Hemorrhage 1 (2%) 1 (2%)
Cerebrum, Necrosis 1 (2%)
Cerebrum, Ventricle, Dilatation 2 (3%)
Hypothalamus, Compression 8 (14%) 1 (2%)
Pons, Compression 2 (3%)
Thalamus, Degeneration 1 (2%)
Ventricle, Dilatation 2 (3%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (57) (57) (57)
Inflammation, Chronic 2 (4%)
Inflammation, Suppurative 1 (2%)
Lung (59) (6) (58) (7) (58) (7)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic 32 (54%) 3 (50%) 58 (100%) 58 (100%) 7 (100%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia, Atypical 4 (7%)
Alveolar Epithelium, Hyperplasia, Focal 2 (3%) 1 (2%)
Alveolar Epithelium, Metaplasia, Squamous 1 (2%)
Alveolus, Pigmentation 1 (2%) 58 (100%) 6 (86%) 58 (100%) 7 (100%)
Nose (59) (6) (58) (7) (58) (7)
Inflammation, Chronic Active 1 (2%) 2 (3%) 2 (3%)
Inflammation, Suppurative 5 (8%) 2 (3%) 3 (5%)
Respiratory Epithelium, Inflammation, Focal,
Suppurative 1 (2%)
Trachea (58) (58) (58)
Inflammation, Focal, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (12) (5) (3)
Cataract 5 (42%) 3 (60%) 1 (33%)
Anterior Chamber, Cornea, Inflammation,
Suppurative 1 (8%)
Bilateral, Cornea, Edema 1 (8%)
Cornea, Edema 2 (17%)
Cornea, Inflammation, Suppurative 1 (20%)
Lids, Inflammation, Chronic Active 1 (20%)
Retina, Degeneration 1 (8%)
Sclera, Metaplasia, Osseous 1 (8%)
Vitreous, Inflammation, Chronic 1 (8%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (6) (58) (7) (58) (7)
Cyst 2 (3%) 1 (2%) 2 (3%)
Infarct 1 (2%)
Necrosis 1 (2%)
Nephropathy 52 (88%) 54 (93%) 53 (91%)
Pigmentation 1 (2%)
Bilateral, Nephropathy 1 (2%)
Bilateral, Cortex, Cyst 1 (2%)
Cortex, Cyst 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Medulla, Cyst 1 (2%)
Pelvis, Degeneration 1 (2%)
Pelvis, Inflammation, Suppurative 1 (2%)
Urinary Bladder (59) (3) (58) (3) (58) (5)
Calculus Micro Observation Only 5 (8%) 3 (100%) 2 (3%) 3 (100%) 4 (7%) 5 (100%)
Inflammation, Subacute 1 (2%)
Metaplasia, Squamous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 58 7
Scheduled Sacrifice 5 7
Early Deaths
Moribund Sacrifice 36
Natural Death 4
Survivors
Natural Death 1
Terminal Sacrifice 11
Other 1
Animals Examined Microscopically 57 7
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (57)
Parasite Metazoan 1 (2%)
Intestine Small, Jejunum (57)
Inflammation, Chronic Active 1 (2%)
Liver (57)
Basophilic Focus 20 (35%)
Congestion 4 (7%)
Degeneration, Cystic 28 (49%)
Developmental Malformation 1 (2%)
Eosinophilic Focus 7 (12%)
Fatty Change 11 (19%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 4 (7%)
Infarct 1 (2%)
Mixed Cell Focus 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 25 (44%)
Hepatocyte, Hyperplasia 11 (19%)
Hepatocyte, Necrosis 10 (18%)
Portal Vein, Thrombosis 1 (2%)
Pancreas (57)
Congestion 1 (2%)
Acinus, Atrophy 2 (4%)
Stomach, Forestomach (57)
Hyperkeratosis 1 (2%)
Stomach, Glandular (57)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (57)
Infarct 1 (2%)
Inflammation, Chronic 1 (2%)
Atrium, Congestion 1 (2%)
Atrium, Thrombosis 4 (7%)
Ventricle, Fibrosis 1 (2%)
Ventricle, Inflammation, Chronic 1 (2%)
Ventricle, Mineralization 1 (2%)
Ventricle, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (57)
Degeneration, Fatty 3 (5%)
Adrenal Medulla (57)
Hyperplasia 26 (46%)
Islets, Pancreatic (57)
Hyperplasia 1 (2%)
Parathyroid Gland (54)
Hyperplasia 2 (4%)
Pituitary Gland (57)
Hyperplasia 1 (2%)
Pars Distalis, Angiectasis 3 (5%)
Pars Distalis, Cyst 2 (4%)
Pars Distalis, Hyperplasia 11 (19%)
Thyroid Gland (57)
C-Cell, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1)
Inflammation, Suppurative 1 (100%)
Preputial Gland (56)
Ectasia 1 (2%)
Hyperplasia, Glandular 1 (2%)
Inflammation, Suppurative 3 (5%)
Prostate (57)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Testes (57)
Atrophy 10 (18%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (57)
Fibrosis 4 (7%)
Hyperplasia 36 (63%)
Lymph Node (15)
Hyperplasia, Macrophage 1 (7%)
Iliac, Pigmentation 1 (7%)
Renal, Edema 1 (7%)
Renal, Pigmentation 2 (13%)
Lymph Node, Bronchial (57) (7)
Congestion 3 (5%)
Edema 1 (2%)
Hyperplasia 1 (14%)
Hyperplasia, Lymphoid 22 (39%) 4 (57%)
Pigmentation 56 (98%) 7 (100%)
Lymph Node, Mandibular (56)
Hyperplasia, Lymphoid 3 (5%)
Lymph Node, Mesenteric (56)
Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mediastinal (56) (6)
Congestion 3 (5%)
Hyperplasia, Lymphoid 19 (34%)
Hyperplasia, Plasma Cell 1 (2%)
Pigmentation 54 (96%) 3 (50%)
Spleen (57)
Fibrosis 10 (18%)
Infarct 2 (4%)
Thymus (53)
Congestion 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (57)
Ectasia 1 (2%)
Skin (7)
Cyst Epithelial Inclusion 1 (14%)
Pigmentation 1 (14%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 21
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (57)
Hyperostosis 2 (4%)
Femur, Hyperostosis 4 (7%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (57)
Hemorrhage 1 (2%)
Cerebellum, Compression 1 (2%)
Cerebrum, Compression 5 (9%)
Cerebrum, Necrosis 1 (2%)
Cerebrum, Ventricle, Dilatation 3 (5%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (56)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 2 (4%)
Lung (57) (7)
Congestion 1 (2%)
Cyst 1 (2%)
Hemorrhage 2 (4%)
Inflammation, Chronic 57 (100%) 7 (100%)
Alveolar Epithelium, Hyperplasia, Atypical 3 (5%)
Alveolus, Pigmentation 57 (100%) 6 (86%)
Nose (57) (7)
Inflammation, Chronic Active 5 (9%)
Inflammation, Suppurative 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5)
Cataract 3 (60%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (57) (7)
Cyst 1 (2%)
Fibrosis 1 (2%)
Infarct 2 (4%)
Nephropathy 47 (82%)
Cortex, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 22
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Medulla, Congestion 1 (2%)
Urinary Bladder (57) (4)
Calculus Micro Observation Only 4 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 23
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---------- END OF REPORT ----------
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