TDMS Study 05123-05 Pathology Tables
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
Core Animals
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 001313991
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25026 Other 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 MG/M3
Include 002 0 MG/M3
Include 005 0.62MGM3
Include 006 0.62MGM3
Include 009 1.25MGM3
Include 010 1.25MGM3
Include 013 2.5MG/M3
Include 014 2.5MG/M3
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|
DAY ON TEST | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|
| 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
| 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Tooth | |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Atrium, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + M + + + + + + + + M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X X|
Pars Distalis, Carcinoma | X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|
DAY ON TEST | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|
| 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
| 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Fibrosarcoma | X |
Osteosarcoma | |
Squamous Cell Carcinoma | X |
Oral, Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X|
Carcinoma | X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Benign | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X|
__________________________________________________________________________|
Vagina | + |
Polyp | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Axillary, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X X |
Popliteal, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + M I +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + M + + + + + +|
Leukemia Mononuclear | X X X X X X |
Squamous Cell Carcinoma, Metastatic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + I + + + + + + + + + + M + + + + + + + + M + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | I + + + + + + I + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Thymoma NOS | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|
DAY ON TEST | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|
| 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
| 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma, Multiple | X |
Fibroadenoma | X X X X|
Fibroadenoma, Multiple | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + |
Basal Cell Adenoma | |
Keratoacanthoma | |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Adrenal Cortex| |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|
| 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Atrium, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + I + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X|
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|
| 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
Fibrosarcoma | |
Osteosarcoma | X |
Squamous Cell Carcinoma | X |
Oral, Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Benign | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X X |
__________________________________________________________________________|
Vagina | + |
Polyp | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + +|
Axillary, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X X |
Popliteal, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + I + + + M + + M + + +|
Leukemia Mononuclear | X X X X X X |
Squamous Cell Carcinoma, Metastatic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + M M|
Leukemia Mononuclear | X X X X X X |
Thymoma NOS | X |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|
| 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma, Multiple | |
Fibroadenoma | X X X X X X|
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + |
Basal Cell Adenoma | X |
Keratoacanthoma | X |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Adrenal Cortex| X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Transitional Epithelium, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 2| 8| | |
| 2| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0 MG/M3 | 2| 2| 3| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Leukemia Mononuclear | X X | 20 |
__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 52 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 52 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Odontoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | X | 1 |
Atrium, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Carcinoma | | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 51 |
Leukemia Mononuclear | | 4 |
Pheochromocytoma Benign | | 3 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 52 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | X | 20 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 2| 8| | |
| 2| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0 MG/M3 | 2| 2| 3| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 6 |
Fibrosarcoma | | 1 |
Osteosarcoma | | 1 |
Squamous Cell Carcinoma | | 2 |
Oral, Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
Adenoma | | 1 |
Carcinoma | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Granulosa-Theca Tumor Benign | | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Polyp Stromal | | 9 |
__________________________________________________________________________|____________|
Vagina | | 2 |
Polyp | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 52 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + | 14 |
Axillary, Leukemia Mononuclear | X | 1 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | X | 4 |
Pancreatic, Leukemia Mononuclear | X X | 9 |
Popliteal, Leukemia Mononuclear | X | 1 |
Renal, Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 49 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 47 |
Leukemia Mononuclear | X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 2| 8| | |
| 2| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0 MG/M3 | 2| 2| 3| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Squamous Cell Carcinoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 51 |
Leukemia Mononuclear | X X | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 48 |
Leukemia Mononuclear | X X | 14 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Leukemia Mononuclear | X X | 22 |
__________________________________________________________________________|____________|
Thymus | + + + | 48 |
Leukemia Mononuclear | X | 10 |
Thymoma NOS | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoma | | 1 |
Carcinoma, Multiple | | 1 |
Fibroadenoma | X | 11 |
Fibroadenoma, Multiple | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | | 4 |
Basal Cell Adenoma | | 1 |
Keratoacanthoma | | 1 |
Squamous Cell Papilloma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Carcinoma, Metastatic | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 1 |
Carcinoma, Metastatic, Adrenal Cortex| | 1 |
Leukemia Mononuclear | X X | 20 |
__________________________________________________________________________|____________|
Nose | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 2| 8| | |
| 2| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0 MG/M3 | 2| 2| 3| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Mononuclear | X | 3 |
Transitional Epithelium, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | X X | 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|
| 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma, Metastatic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Osteosarcoma, Metastatic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Osteosarcoma, Metastatic | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + M + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Carcinoma | X X |
Pars Distalis, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fibrous Histiocytoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|
| 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Bilateral, Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Leukemia Mononuclear | |
Axillary, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + M + + + M I + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + M + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + I + + + M M + M + + + + + M + M +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + I + M + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + |
Hemangioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Rib, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|
| 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Carcinoma, Metastatic | X X |
Cerebrum, Carcinoma, Metastatic | X X |
Cerebrum, Osteosarcoma, Metastatic | |
Hypothalamus, Carcinoma, Metastatic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Osteosarcoma, Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesenchymal Tumor NOS | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|
| 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma, Metastatic | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Osteosarcoma, Metastatic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Osteosarcoma, Metastatic | X |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + I + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X |
Pars Distalis, Carcinoma | X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Fibrous Histiocytoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|
| 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Bilateral, Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X|
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Leukemia Mononuclear | X |
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | I + + + + + + + + + + + M + + M M + + + + + + + I|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + |
Hemangioma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Rib, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|
| 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Carcinoma, Metastatic | |
Cerebrum, Carcinoma, Metastatic | X |
Cerebrum, Osteosarcoma, Metastatic | X |
Hypothalamus, Carcinoma, Metastatic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Osteosarcoma, Metastatic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesenchymal Tumor NOS | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| | |
| 0| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.62MGM3 | 5| 5| 5| | L |
| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | | 13 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + M | 52 |
Osteosarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 1 |
Osteosarcoma, Metastatic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 52 |
Leukemia Mononuclear | | 2 |
Pheochromocytoma Benign | | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 1 |
Osteosarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Pars Distalis, Adenoma | X | 21 |
Pars Distalis, Carcinoma | | 3 |
Pars Distalis, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
C-Cell, Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| | |
| 0| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.62MGM3 | 5| 5| 5| | L |
| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Fibrous Histiocytoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
Adenoma | X | 4 |
Bilateral, Adenoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Polyp Stromal | | 2 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
__________________________________________________________________________|____________|
Lymph Node | | 6 |
Leukemia Mononuclear | | 1 |
Axillary, Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | | 3 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 50 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M | 45 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Mononuclear | | 13 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 46 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Hemangiosarcoma | | 1 |
Leukemia Mononuclear | | 19 |
__________________________________________________________________________|____________|
Thymus | + + + | 49 |
Leukemia Mononuclear | | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| | |
| 0| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.62MGM3 | 5| 5| 5| | L |
| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Adenoma | | 1 |
Fibroadenoma | | 11 |
Fibroadenoma, Multiple | | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | | 3 |
Hemangioma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
Rib, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Cerebellum, Carcinoma, Metastatic | | 2 |
Cerebrum, Carcinoma, Metastatic | | 3 |
Cerebrum, Osteosarcoma, Metastatic | | 1 |
Hypothalamus, Carcinoma, Metastatic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Leukemia Mononuclear | | 11 |
Osteosarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + | 53 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Mononuclear | | 2 |
Mesenchymal Tumor NOS | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | | 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|
DAY ON TEST | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|
| 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + I +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Sarcoma, Metastatic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + I + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Leukemia Mononuclear | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X|
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Lipoma | X |
Liposarcoma | X |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|
DAY ON TEST | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|
| 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Adenoma | |
Bilateral, Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + I + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + |
Leukemia Mononuclear | X |
Axillary, Leukemia Mononuclear | X X |
Iliac, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + M + + + M +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + M + + + M + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X|
Carcinoma, Multiple | X |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|
DAY ON TEST | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|
| 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Schwannoma Malignant, | |
Metastatic, Peripheral Nerve | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Carcinoma, Metastatic | |
Cerebrum, Glioma NOS | |
__________________________________________________________________________|
Peripheral Nerve | + |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X|
Alveolar/Bronchiolar Carcinoma, | |
Squamous Differentiation | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Liposarcoma | |
Nephroblastoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|
DAY ON TEST | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|
| 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Sarcoma, Metastatic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Leukemia Mononuclear | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X X|
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Carcinoma | X |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Lipoma | X |
Liposarcoma | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|
DAY ON TEST | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|
| 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Bilateral, Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Polyp Stromal | X X X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Leukemia Mononuclear | |
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + M + + + + M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X|
Carcinoma | X |
Carcinoma, Multiple | |
Fibroadenoma | X X X X X X X X |
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + +|
Subcutaneous Tissue, Fibroma | X|
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|
DAY ON TEST | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|
| 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Schwannoma Malignant, | |
Metastatic, Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Carcinoma, Metastatic | X |
Cerebrum, Glioma NOS | X |
__________________________________________________________________________|
Peripheral Nerve | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Squamous Differentiation | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Liposarcoma | |
Nephroblastoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 5| 6| 4| | |
DAY ON TEST | 1| 2| 3| | |
| 4| 7| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 8| 8| 8| | L |
| 6| 7| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
Sarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Leukemia Mononuclear | X X | 14 |
Sarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Aorta, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Leukemia Mononuclear | | 2 |
Pheochromocytoma Benign | | 5 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Pars Distalis, Adenoma | X | 19 |
Pars Distalis, Carcinoma | | 1 |
Pars Distalis, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Adenoma | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 5| 6| 4| | |
DAY ON TEST | 1| 2| 3| | |
| 4| 7| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 8| 8| 8| | L |
| 6| 7| 9| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Lipoma | | 2 |
Liposarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + | 51 |
Adenoma | | 1 |
Bilateral, Adenoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + | 52 |
Leukemia Mononuclear | | 1 |
Polyp Stromal | | 6 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
__________________________________________________________________________|____________|
Lymph Node | + | 9 |
Leukemia Mononuclear | | 1 |
Axillary, Leukemia Mononuclear | X | 3 |
Iliac, Leukemia Mononuclear | X | 5 |
Pancreatic, Leukemia Mononuclear | | 4 |
Renal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 53 |
Leukemia Mononuclear | X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
Leukemia Mononuclear | X X | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + | 48 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Leukemia Mononuclear | X X | 21 |
__________________________________________________________________________|____________|
Thymus | + M + | 47 |
Leukemia Mononuclear | | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 5| 6| 4| | |
DAY ON TEST | 1| 2| 3| | |
| 4| 7| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 8| 8| 8| | L |
| 6| 7| 9| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoma | | 1 |
Carcinoma | | 2 |
Carcinoma, Multiple | | 1 |
Fibroadenoma | | 13 |
Fibroadenoma, Multiple | | 2 |
__________________________________________________________________________|____________|
Skin | | 3 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
Vertebra, Schwannoma Malignant, | | |
Metastatic, Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Cerebrum, Carcinoma, Metastatic | | 1 |
Cerebrum, Glioma NOS | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Squamous Differentiation | | 2 |
Leukemia Mononuclear | X X | 10 |
__________________________________________________________________________|____________|
Nose | + + + | 52 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 5| 6| 4| | |
DAY ON TEST | 1| 2| 3| | |
| 4| 7| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 8| 8| 8| | L |
| 6| 7| 9| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Liposarcoma | X | 1 |
Nephroblastoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | X X | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4| 7|
DAY ON TEST | 3| 7| 3| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9| 3|
| 2| 1| 2| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 7| 8| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lipoma | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Mesentery | +|
Lipoma | X|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Adenoma | X|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X X X X X X |
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Fibroma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4| 7|
DAY ON TEST | 3| 7| 3| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9| 3|
| 2| 1| 2| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 7| 8| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + M|
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + M + + + M|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + M + M +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + M + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Fibroadenoma | X X X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + |
Fibroma | X |
Papilloma | X |
Squamous Cell Carcinoma | X |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4| 7|
DAY ON TEST | 3| 7| 3| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9| 3|
| 2| 1| 2| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 7| 8| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | |
Cerebellum, Carcinoma, Metastatic | X |
Cerebrum, Carcinoma, Metastatic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma, | |
Squamous Differentiation | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mixed Tumor Malignant | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3| 9|
| 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.5MG/M3 | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lipoma | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Mesentery | |
Lipoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + I + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Adenoma | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Benign | X X X X X |
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Fibroma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3| 9|
| 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.5MG/M3 | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M M + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + I + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + M + + + M + + M + M + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
Fibroadenoma | X X X X X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | |
Fibroma | |
Papilloma | |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3| 9|
| 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.5MG/M3 | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | X |
Cerebellum, Carcinoma, Metastatic | |
Cerebrum, Carcinoma, Metastatic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma, | |
Squamous Differentiation | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mixed Tumor Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 6| 7| 7| | |
DAY ON TEST | 0| 0| 3| | |
| 7| 4| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| | A |
2.5MG/M3 | 1| 1| 2| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
Lipoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X | 17 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Lipoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
Parotid Gland, Adenoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 52 |
Leukemia Mononuclear | | 2 |
Pheochromocytoma Benign | X | 13 |
Bilateral, Pheochromocytoma Benign | | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Adenoma | X X | 20 |
Pars Distalis, Carcinoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Adenoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 6| 7| 7| | |
DAY ON TEST | 0| 0| 3| | |
| 7| 4| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| | A |
2.5MG/M3 | 1| 1| 2| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + | 49 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + | 53 |
__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Polyp Stromal | | 5 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
__________________________________________________________________________|____________|
Lymph Node | | 3 |
Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 51 |
Leukemia Mononuclear | X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 48 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 50 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________|____________|
Thymus | + + + | 46 |
Leukemia Mononuclear | | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoma | | 1 |
Carcinoma | | 1 |
Fibroadenoma | X X | 12 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 6| 7| 7| | |
DAY ON TEST | 0| 0| 3| | |
| 7| 4| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| | A |
2.5MG/M3 | 1| 1| 2| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | | 5 |
Fibroma | | 1 |
Papilloma | | 1 |
Squamous Cell Carcinoma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Carcinoma, Metastatic | | 1 |
Cerebellum, Carcinoma, Metastatic | | 1 |
Cerebrum, Carcinoma, Metastatic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 3 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Squamous Differentiation | | 1 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Nose | + + + | 53 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Mononuclear | | 1 |
Mixed Tumor Malignant | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 6| 7| 7| | |
DAY ON TEST | 0| 0| 3| | |
| 7| 4| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| | A |
2.5MG/M3 | 1| 1| 2| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|
DAY ON TEST | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|
| 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Benign | X X X X X X X|
Bilateral, Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + + + + + + + + M + M + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Distalis, Leukemia Mononuclear | X |
Pars Intermedia, Leukemia Mononuclear| X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|
DAY ON TEST | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|
| 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Oral, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Axillary, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X X X X |
Pancreatic, Leukemia Mononuclear | X X X |
Popliteal, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + I + + + + + + + + + + + + + + I|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | M I + + M + + + + + M + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + M + + + + + + M + M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|
DAY ON TEST | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|
| 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + +|
Basal Cell Adenoma | |
Fibroma | X X|
Keratoacanthoma | X |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Cerebellum, Leukemia Mononuclear | X |
Cerebrum, Leukemia Mononuclear | X |
__________________________________________________________________________|
Peripheral Nerve | |
Ganglion, Paraganglioma Benign | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|
DAY ON TEST | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|
| 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Benign | X X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | |
Pars Intermedia, Leukemia Mononuclear| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|
DAY ON TEST | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|
| 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Oral, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Axillary, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X X X X |
Pancreatic, Leukemia Mononuclear | X X X X X |
Popliteal, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + M + + + + + + + + + M + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + M + + + I + + + + I I M + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|
DAY ON TEST | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|
| 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + |
Basal Cell Adenoma | X |
Fibroma | X |
Keratoacanthoma | |
Subcutaneous Tissue, | |
Neurofibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Cerebellum, Leukemia Mononuclear | |
Cerebrum, Leukemia Mononuclear | X |
__________________________________________________________________________|
Peripheral Nerve | + |
Ganglion, Paraganglioma Benign | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 6| 7| 3| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| | L |
| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 54 |
Peyer's Patch, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Hepatocellular Carcinoma | | 2 |
Hepatocellular Adenoma | | 3 |
Leukemia Mononuclear | X | 27 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
__________________________________________________________________________|____________|
Heart | + + + + | 54 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 54 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 54 |
Leukemia Mononuclear | | 4 |
Pheochromocytoma Benign | X X X | 17 |
Bilateral, Pheochromocytoma Benign | X | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
Adenoma | X | 2 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 50 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 53 |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | X X X | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 6| 7| 3| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| | L |
| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Leukemia Mononuclear | | 1 |
Pars Intermedia, Leukemia Mononuclear| | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 54 |
C-Cell, Adenoma | | 6 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Oral, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 4 |
__________________________________________________________________________|____________|
Epididymis | + + + + | 54 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 54 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + | 53 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 54 |
__________________________________________________________________________|____________|
Testes | + + + + | 54 |
Bilateral, Interstitial Cell, Adenoma| X X | 20 |
Interstitial Cell, Adenoma | X | 20 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 16 |
Axillary, Leukemia Mononuclear | | 1 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | X | 9 |
Pancreatic, Leukemia Mononuclear | | 8 |
Popliteal, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + | 52 |
Leukemia Mononuclear | X | 17 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M | 49 |
Leukemia Mononuclear | | 17 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 6| 7| 3| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| | L |
| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 18 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + | 47 |
Leukemia Mononuclear | X | 18 |
__________________________________________________________________________|____________|
Spleen | + + + + | 54 |
Leukemia Mononuclear | X X | 31 |
__________________________________________________________________________|____________|
Thymus | + + M + | 44 |
Leukemia Mononuclear | | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 54 |
Fibroadenoma | X | 2 |
__________________________________________________________________________|____________|
Skin | + | 13 |
Basal Cell Adenoma | X | 2 |
Fibroma | | 3 |
Keratoacanthoma | | 1 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 54 |
Leukemia Mononuclear | | 1 |
Cerebellum, Leukemia Mononuclear | | 1 |
Cerebrum, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Ganglion, Paraganglioma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 52 |
__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Leukemia Mononuclear | X X | 27 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + | 54 |
__________________________________________________________________________|____________|
Trachea | + + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 6| 7| 3| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| | L |
| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 54 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 54 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 54 |
Leukemia Mononuclear | X X | 31 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|
| 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Peyer's Patch, Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Adenoma, Multiple | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M M + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|
| 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mesothelioma Malignant, Metastatic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Fibrous Histiocytoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X |
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Leukemia Mononuclear | X |
Axillary, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X X |
Renal, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|
| 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + |
Fibroma | |
Keratoacanthoma | X |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pelvis, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granular Cell Tumor NOS | |
Cerebellum, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lids, Fibroma | X |
__________________________________________________________________________|
Harderian Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|
| 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Peyer's Patch, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | |
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Mesothelioma Malignant, Metastatic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X X X X X X|
Bilateral, Pheochromocytoma Benign | X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Adenoma, Multiple | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Distalis, Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|
| 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
Follicular Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Mesothelioma Malignant, Metastatic | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Fibrous Histiocytoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Leukemia Mononuclear | X |
Axillary, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X X |
Inguinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X X X |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + M|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|
| 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + |
Fibroma | X |
Keratoacanthoma | |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pelvis, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granular Cell Tumor NOS | X |
Cerebellum, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lids, Fibroma | |
__________________________________________________________________________|
Harderian Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 7| 3| | |
| 2| 9| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.62MGM3 | 9| 9| 9| | L |
| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
Fibroma | | 1 |
Peyer's Patch, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hemangioma | | 1 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | | 5 |
Hepatocellular Adenoma, Multiple | | 1 |
Leukemia Mononuclear | X | 28 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Mesothelioma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 52 |
Leukemia Mononuclear | | 3 |
Pheochromocytoma Benign | X | 13 |
Bilateral, Pheochromocytoma Benign | X | 11 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 2 |
Adenoma, Multiple | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 7| 3| | |
| 2| 9| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.62MGM3 | 9| 9| 9| | L |
| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Pars Distalis, Adenoma | X X | 18 |
Pars Distalis, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Adenoma | | 5 |
Follicular Cell, Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Mesothelioma Malignant, Metastatic | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + | 53 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 53 |
Adenoma | | 3 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + | 53 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 53 |
__________________________________________________________________________|____________|
Testes | + + + | 53 |
Bilateral, Interstitial Cell, Adenoma| X X | 36 |
Interstitial Cell, Adenoma | X | 10 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
__________________________________________________________________________|____________|
Lymph Node | + + | 19 |
Leukemia Mononuclear | | 2 |
Axillary, Leukemia Mononuclear | | 2 |
Iliac, Leukemia Mononuclear | | 3 |
Inguinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 7 |
Renal, Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 51 |
Leukemia Mononuclear | X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 7| 3| | |
| 2| 9| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.62MGM3 | 9| 9| 9| | L |
| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
Leukemia Mononuclear | | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Mononuclear | X | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 52 |
Leukemia Mononuclear | X | 18 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Leukemia Mononuclear | X | 32 |
__________________________________________________________________________|____________|
Thymus | + + + | 49 |
Leukemia Mononuclear | X | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
__________________________________________________________________________|____________|
Skin | | 4 |
Fibroma | | 1 |
Keratoacanthoma | | 1 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
Pelvis, Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Granular Cell Tumor NOS | | 1 |
Cerebellum, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 52 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X | 23 |
__________________________________________________________________________|____________|
Nose | + + + | 53 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Lids, Fibroma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 7| 3| | |
| 2| 9| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.62MGM3 | 9| 9| 9| | L |
| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | X | 32 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|
| 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anus, Leiomyoma | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|
| 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Lipoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Leukemia Mononuclear | X |
Axillary, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X X X X |
Renal, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Squamous Cell Carcinoma, Metastatic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|
| 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | M + + + M + + + + + + + + + + + M M + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Skin | + + + + + +|
Basal Cell Adenoma | X |
Fibroma | X|
Keratoacanthoma | |
Lipoma | X |
Squamous Cell Papilloma | X |
Trichoepithelioma | |
Scrotum, Fibroma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | X |
Leukemia Mononuclear | |
Cerebellum, Leukemia Mononuclear | |
Cerebrum, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Squamous Differentiation | X |
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Fibroma | X |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|
| 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Renal Tubule, Adenoma | |
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|
DAY ON TEST | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|
| 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +|
Anus, Leiomyoma | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + M + + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|
DAY ON TEST | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|
| 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Lipoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + +|
Leukemia Mononuclear | |
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X X|
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Squamous Cell Carcinoma, Metastatic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|
DAY ON TEST | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|
| 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosarcoma | |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + |
Basal Cell Adenoma | |
Fibroma | |
Keratoacanthoma | X |
Lipoma | |
Squamous Cell Papilloma | |
Trichoepithelioma | X |
Scrotum, Fibroma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | |
Leukemia Mononuclear | |
Cerebellum, Leukemia Mononuclear | |
Cerebrum, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Squamous Differentiation | X |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Fibroma | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|
DAY ON TEST | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|
| 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Renal Tubule, Adenoma | X |
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 5| 4| 6| | |
DAY ON TEST | 1| 5| 8| | |
| 9| 7| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 2| 2| 2| | L |
| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
Anus, Leiomyoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
Peyer's Patch, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | | 3 |
Leukemia Mononuclear | X X X | 20 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Leukemia Mononuclear | X | 3 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X | 17 |
Bilateral, Pheochromocytoma Benign | X | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 2 |
Carcinoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 5| 4| 6| | |
DAY ON TEST | 1| 5| 8| | |
| 9| 7| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 2| 2| 2| | L |
| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + | 49 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Pars Distalis, Adenoma | X | 16 |
Pars Distalis, Leukemia Mononuclear | X | 2 |
Pars Intermedia, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | M + + | 52 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | | 4 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Lipoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + | 53 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 53 |
Adenoma | | 2 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + | 53 |
Adenoma | | 1 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Testes | + + + | 53 |
Bilateral, Interstitial Cell, Adenoma| X | 27 |
Interstitial Cell, Adenoma | X X | 16 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + | 16 |
Leukemia Mononuclear | | 1 |
Axillary, Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | X X | 6 |
Pancreatic, Leukemia Mononuclear | X X | 10 |
Renal, Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 5| 4| 6| | |
DAY ON TEST | 1| 5| 8| | |
| 9| 7| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 2| 2| 2| | L |
| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 53 |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 50 |
Leukemia Mononuclear | X X X | 14 |
Squamous Cell Carcinoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Mononuclear | X X X | 18 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 52 |
Leukemia Mononuclear | X X X | 21 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Fibrosarcoma | X | 1 |
Leukemia Mononuclear | X X X | 26 |
__________________________________________________________________________|____________|
Thymus | + + + | 47 |
Leukemia Mononuclear | X | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Fibroadenoma | X | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Skin | | 14 |
Basal Cell Adenoma | | 1 |
Fibroma | | 1 |
Keratoacanthoma | | 1 |
Lipoma | | 1 |
Squamous Cell Papilloma | | 1 |
Trichoepithelioma | | 1 |
Scrotum, Fibroma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Astrocytoma NOS | | 1 |
Leukemia Mononuclear | X | 1 |
Cerebellum, Leukemia Mononuclear | X | 1 |
Cerebrum, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 5| 4| 6| | |
DAY ON TEST | 1| 5| 8| | |
| 9| 7| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 2| 2| 2| | L |
| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 3 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Squamous Differentiation | | 2 |
Leukemia Mononuclear | X X X | 21 |
__________________________________________________________________________|____________|
Nose | + + + | 53 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Fibroma | | 1 |
__________________________________________________________________________|____________|
Eye | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Mononuclear | X X | 7 |
Renal Tubule, Adenoma | | 1 |
Transitional Epithelium, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | X X X | 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|
| 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic | X |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | |
Histiocytic Sarcoma, Metastatic, Skin| |
Leukemia Mononuclear | X X X X X X X X X X X X X X |
Mesothelioma Malignant, Metastatic | X |
__________________________________________________________________________|
Mesentery | + |
Mesothelioma Malignant, Metastatic, | |
Testes | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Submandibular Gland, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Testes | X |
Lymphatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic | X |
Lymphatic, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|
| 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X X X |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + M + + + + +|
Bilateral, Leukemia Mononuclear | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
Basal Cell Carcinoma | X |
Carcinoma, Metastatic, Lung | X |
Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|
| 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Leukemia Mononuclear | |
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X |
Pheochromocytoma Malignant, | |
Metastatic | X |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + |
Keratoacanthoma | X |
Papilloma | |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Fibrous Histiocytoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
Ganglion, Paraganglioma Benign | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|
| 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Fibrous Histiocytoma, Metastatic | X |
Histiocytic Sarcoma, Metastatic, Skin| |
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant, | |
Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, Skin| |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|
| 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic | |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X |
Histiocytic Sarcoma, Metastatic, Skin| X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Mesentery | |
Mesothelioma Malignant, Metastatic, | |
Testes | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submandibular Gland, Leukemia | |
Mononuclear | X|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Testes | |
Lymphatic, Leukemia Mononuclear | X|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic | |
Lymphatic, Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|
| 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X X X |
Pheochromocytoma Benign | X X X X X X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Leukemia Mononuclear | X|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Basal Cell Carcinoma | |
Carcinoma, Metastatic, Lung | |
Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X X X |
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|
| 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Axillary, Leukemia Mononuclear | X|
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X X X X X|
Renal, Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
Pheochromocytoma Malignant, | |
Metastatic | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + M + + + + + + + +|
Carcinoma, Metastatic, Lung | |
Leukemia Mononuclear | X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphatic, Leukemia Mononuclear | X|
__________________________________________________________________________|
Skin | + + + + |
Keratoacanthoma | |
Papilloma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Fibrous Histiocytoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
Ganglion, Paraganglioma Benign | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|
| 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Fibrous Histiocytoma, Metastatic | |
Histiocytic Sarcoma, Metastatic, Skin| X |
Leukemia Mononuclear | X X X X X X X X X X X|
Pheochromocytoma Malignant, | |
Metastatic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, Skin| X |
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 4| 6| 7| | |
DAY ON TEST | 7| 4| 1| | |
| 5| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 5| | L |
| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 52 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 51 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 52 |
Mesothelioma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 51 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + | 52 |
Fibrous Histiocytoma, Metastatic | | 1 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | | 2 |
Histiocytic Sarcoma, Metastatic, Skin| | 1 |
Leukemia Mononuclear | | 29 |
Mesothelioma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
Leukemia Mononuclear | | 3 |
Mesothelioma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
Submandibular Gland, Leukemia | | |
Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 52 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
Lymphatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 52 |
Mesothelioma Malignant, Metastatic | | 1 |
Lymphatic, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 4| 6| 7| | |
DAY ON TEST | 7| 4| 1| | |
| 5| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 5| | L |
| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 52 |
Carcinoma, Metastatic, Lung | | 1 |
Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 52 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 52 |
Leukemia Mononuclear | X | 5 |
Pheochromocytoma Malignant | | 6 |
Pheochromocytoma Benign | X | 16 |
Bilateral, Pheochromocytoma Benign | X | 16 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 52 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + | 49 |
Bilateral, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Pars Distalis, Adenoma | | 12 |
Pars Distalis, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
C-Cell, Adenoma | | 2 |
Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 4 |
Basal Cell Carcinoma | | 1 |
Carcinoma, Metastatic, Lung | | 1 |
Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + | 52 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 51 |
Adenoma | | 2 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 4| 6| 7| | |
DAY ON TEST | 7| 4| 1| | |
| 5| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 5| | L |
| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 52 |
Leukemia Mononuclear | | 2 |
Mesothelioma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Testes | + + + | 52 |
Leukemia Mononuclear | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X | 26 |
Interstitial Cell, Adenoma | | 21 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 52 |
__________________________________________________________________________|____________|
Lymph Node | | 15 |
Leukemia Mononuclear | | 2 |
Axillary, Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | | 2 |
Pancreatic, Leukemia Mononuclear | | 7 |
Renal, Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 52 |
Leukemia Mononuclear | X | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
Leukemia Mononuclear | X | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 51 |
Leukemia Mononuclear | | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 52 |
Leukemia Mononuclear | X | 16 |
__________________________________________________________________________|____________|
Spleen | + + + | 52 |
Leukemia Mononuclear | X | 35 |
Pheochromocytoma Malignant, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + | 48 |
Carcinoma, Metastatic, Lung | | 1 |
Leukemia Mononuclear | | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 52 |
Lymphatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | | 6 |
Keratoacanthoma | | 1 |
Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 83
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 4| 6| 7| | |
DAY ON TEST | 7| 4| 1| | |
| 5| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 5| | L |
| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 52 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Fibrous Histiocytoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 52 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Ganglion, Paraganglioma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 51 |
__________________________________________________________________________|____________|
Lung | + + + | 52 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Fibrous Histiocytoma, Metastatic | | 1 |
Histiocytic Sarcoma, Metastatic, Skin| | 1 |
Leukemia Mononuclear | X | 14 |
Pheochromocytoma Malignant, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + | 52 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 52 |
Histiocytic Sarcoma, Metastatic, Skin| | 1 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 52 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 84
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:32:20
__________________________________________________________________________________________________________________________________
| 4| 6| 7| | |
DAY ON TEST | 7| 4| 1| | |
| 5| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 5| | L |
| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X | 35 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 85
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