TDMS Study 05123-05 Pathology Tables
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:09:51
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 001313991
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25026 Other 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 003 0 MG/M3 LUNGTX
Include 004 0 MG/M3 LUNGTX
Include 007 0.62MGM3 LUNGTX
Include 008 0.62MGM3 LUNGTX
Include 011 1.25MGM3 LUNGTX
Include 012 1.25MGM3 LUNGTX
Include 015 2.5MG/M3 LUNGTX
Include 016 2.5MG/M3 LUNGTX
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:09:51
__________________________________________________________________________________________________________________________________
| 0| | |
DAY ON TEST | 9| | |
| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
2.5MG/M3 | 6| | L |
LUNGTX | 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Liver | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | M | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________|____________|
Ovary | + | 1 |
__________________________________________________________________________|____________|
Uterus | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M | |
__________________________________________________________________________|____________|
Spleen | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 05123-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:09:51
__________________________________________________________________________________________________________________________________
| 0| | |
DAY ON TEST | 9| | |
| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
2.5MG/M3 | 6| | L |
LUNGTX | 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
__________________________________________________________________________|____________|
Lung | + | 1 |
__________________________________________________________________________|____________|
Nose | + | 1 |
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------