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TDMS Study 05123-05 Pathology Tables

NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:09:51




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  001313991

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25026 Other                             25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 003    0 MG/M3 LUNGTX
                               Include 004    0 MG/M3 LUNGTX
                               Include 007    0.62MGM3 LUNGTX
                               Include 008    0.62MGM3 LUNGTX
                               Include 011    1.25MGM3 LUNGTX
                               Include 012    1.25MGM3 LUNGTX
                               Include 015    2.5MG/M3 LUNGTX
                               Include 016    2.5MG/M3 LUNGTX




























Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:09:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0|                                                                       |            |
                             DAY ON TEST   | 9|                                                                       |            |
                                           | 0|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |     T      |
                               ANIMAL ID   | 4|                                                                       |     A      |
    2.5MG/M3                               | 6|                                                                       |     L      |
     LUNGTX                                | 1|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M                                                                        |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M                                                                        |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M                                                                        |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:09:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0|                                                                       |            |
                             DAY ON TEST   | 9|                                                                       |            |
                                           | 0|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |     T      |
                               ANIMAL ID   | 4|                                                                       |     A      |
    2.5MG/M3                               | 6|                                                                       |     L      |
     LUNGTX                                | 1|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   3                                                               
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