TDMS Study 05123-05 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
NICKEL OXIDE
NTP Experiment-Test: 05123-05 Report: PEIRPT05
Study Type: CHRONIC Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 001313991
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 58 7 58 7 58 7
Scheduled Sacrifice 5 7 5 7 5 7
Early Deaths
Moribund Sacrifice 27 24 27
Natural Death 5 3 6
Survivors
Terminal Sacrifice 21 26 20
Animals Examined Microscopically 58 7 58 7 58 7
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (57) (58) (58)
Sarcoma, Metastatic 1 (2%)
Liver (58) (1) (58) (58)
Hepatocellular Adenoma 1 (2%)
Sarcoma, Metastatic 1 (2%)
Mesentery (1)
Lipoma 1 (100%)
Pancreas (57) (58) (58)
Salivary Glands (57) (57) (56)
Osteosarcoma, Metastatic 1 (2%)
Tooth (1)
Odontoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (1) (2)
Heart (58) (58) (58)
Osteosarcoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58) (58) (58)
Carcinoma 1 (2%)
Adrenal Medulla (56) (57) (57)
Pheochromocytoma Benign 3 (5%) 7 (12%) 5 (9%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (57) (58) (58)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
Page 2
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pituitary Gland (57) (57) (2) (57) (3)
Pars Distalis, Adenoma 21 (37%) 24 (42%) 19 (33%)
Pars Distalis, Carcinoma 1 (2%) 3 (5%) 1 (2%)
Thyroid Gland (57) (57) (58)
C-Cell, Adenoma 2 (4%) 2 (4%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (6) (1) (3)
Fibrosarcoma 1 (17%)
Fibrous Histiocytoma 1 (100%)
Lipoma 2 (67%)
Liposarcoma 1 (33%)
Osteosarcoma 1 (17%)
Squamous Cell Carcinoma 2 (33%)
Oral, Squamous Cell Carcinoma 1 (17%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (58) (58) (56)
Adenoma 1 (2%) 4 (7%) 1 (2%)
Carcinoma 2 (3%)
Bilateral, Adenoma 1 (2%) 1 (2%)
Ovary (58) (58) (58) (2)
Granulosa-Theca Tumor Benign 1 (2%)
Uterus (58) (58) (57)
Polyp Stromal 9 (16%) 2 (3%) 8 (14%)
Vagina (2) (1) (1)
Polyp 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (57) (58) (58)
Lymph Node (14) (6) (9)
Lymph Node, Bronchial (54) (6) (55) (7) (58) (7)
Lymph Node, Mandibular (52) (50) (56)
Squamous Cell Carcinoma, Metastatic 1 (2%)
Lymph Node, Mesenteric (56) (58) (58)
Lymph Node, Mediastinal (53) (6) (51) (7) (52) (6)
Spleen (58) (58) (58)
Hemangiosarcoma 1 (2%)
Thymus (53) (54) (1) (52)
Thymoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (58) (58)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 2 (3%)
Carcinoma, Multiple 1 (2%) 1 (2%)
Fibroadenoma 11 (19%) 11 (19%) 13 (22%)
Fibroadenoma, Multiple 1 (2%) 3 (5%) 2 (3%)
Skin (4) (3) (3)
Basal Cell Adenoma 1 (25%)
Hemangioma 1 (33%)
Keratoacanthoma 1 (25%)
Squamous Cell Papilloma 2 (50%)
Subcutaneous Tissue, Fibroma 1 (33%)
Subcutaneous Tissue, Sarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58) (58) (58)
Rib, Osteosarcoma 1 (2%)
Vertebra, Schwannoma Malignant, Metastatic,
Peripheral Nerve 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58) (58) (58)
Carcinoma, Metastatic 1 (2%)
Cerebellum, Carcinoma, Metastatic 2 (3%)
Cerebrum, Carcinoma, Metastatic 3 (5%) 1 (2%)
Cerebrum, Glioma NOS 1 (2%)
Cerebrum, Osteosarcoma, Metastatic 1 (2%)
Hypothalamus, Carcinoma, Metastatic 1 (2%)
Peripheral Nerve (1)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (58) (7) (58) (7) (58) (7)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 3 (5%)
Alveolar/Bronchiolar Carcinoma, Squamous
Differentiation 2 (3%)
Carcinoma, Metastatic, Adrenal Cortex 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
Page 4
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (7) (58) (7) (58) (7)
Liposarcoma 1 (2%)
Mesenchymal Nos 1 (2%)
Nephroblastoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (57) (58) (58)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(58) *(7) *(58) *(7) *(58) *(7)
Leukemia Mononuclear 22 (38%) 19 (33%) 21 (36%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 53 53 53 1
Total Primary Neoplasms 93 84 95 1
Total Animals with Benign Neoplasms 40 42 39 1
Total Benign Neoplasms 59 58 59 1
Total Animals with Malignant Neoplasms 32 25 30
Total Malignant Neoplasms 33 25 35
Total Animals with Metastatic Neoplasms 3 5 3
Total Metastatic Neoplasm 3 11 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1 1
Total Uncertain Neoplasms 1 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 58 7
Scheduled Sacrifice 5 6
Early Deaths
Moribund Sacrifice 24 1
Natural Death 3
Survivors
Terminal Sacrifice 26
Animals Examined Microscopically 58 7
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (58) (1)
Lipoma 1 (2%)
Liver (58) (1)
Hepatocellular Adenoma 1 (2%)
Mesentery (1)
Lipoma 1 (100%)
Salivary Glands (57) (1)
Parotid Gland, Adenoma 1 (2%)
Stomach, Forestomach (58) (1)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (58) (1)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58) (1)
Adrenal Medulla (57) (1)
Pheochromocytoma Benign 13 (23%)
Bilateral, Pheochromocytoma Benign 5 (9%)
Pituitary Gland (58) (2)
Pars Distalis, Adenoma 21 (36%)
Pars Distalis, Carcinoma 2 (3%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (58)
C-Cell, Adenoma 2 (3%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (3)
Fibroma 1 (33%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (54) (1)
Carcinoma 1 (2%)
Uterus (58) (1)
Polyp Stromal 6 (10%)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (4)
Lymph Node, Bronchial (56) (7)
Lymph Node, Mandibular (53) (1)
Lymph Node, Mesenteric (58) (1)
Lymph Node, Mediastinal (54) (5)
Spleen (58) (1)
Thymus (51) (1)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (1)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Fibroadenoma 12 (21%)
Skin (5)
Fibroma 1 (20%)
Papilloma 1 (20%)
Squamous Cell Carcinoma 1 (20%)
Subcutaneous Tissue, Fibroma 1 (20%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58) (1)
Carcinoma, Metastatic 1 (2%)
Cerebellum, Carcinoma, Metastatic 1 (2%)
Cerebrum, Carcinoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (58) (7)
Alveolar/Bronchiolar Adenoma 3 (5%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma, Squamous
Differentiation 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (7)
Mixed Tumor Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(58) *(7)
Leukemia Mononuclear 18 (31%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 53
Total Primary Neoplasms 100
Total Animals with Benign Neoplasms 44
Total Benign Neoplasms 73
Total Animals with Malignant Neoplasms 25
Total Malignant Neoplasms 27
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 10
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 59 6 58 7 58 7
Scheduled Sacrifice 5 6 5 7 5 7
Early Deaths
Moribund Sacrifice 39 35 32
Natural Death 1 3 6
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 14 15 14
Animals Examined Microscopically 59 6 58 7 58 7
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (59) (58) (57)
Anus, Leiomyoma 1 (2%)
Intestine Small, Ileum (59) (58) (58)
Fibroma 1 (2%)
Liver (59) (58) (58) (1)
Hemangioma 1 (2%)
Hepatocellular Carcinoma 2 (3%) 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 3 (5%) 5 (9%) 3 (5%)
Hepatocellular Adenoma, Multiple 1 (2%)
Mesentery (1) (1)
Pancreas (59) (58) (58)
Salivary Glands (59) (58) (58)
Squamous Cell Carcinoma 1 (2%)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (58) (58)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (58) (58)
Adenoma 1 (2%)
Adrenal Medulla (59) (57) (58)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 17 (29%) 13 (23%) 19 (33%)
Page 11
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Bilateral, Pheochromocytoma Benign 10 (17%) 11 (19%) 9 (16%)
Islets, Pancreatic (59) (58) (58)
Adenoma 2 (3%) 2 (3%) 2 (3%)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (2%) 1 (2%) 2 (3%)
Parathyroid Gland (54) (55) (54)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (58) (57) (57)
Pars Distalis, Adenoma 24 (41%) 19 (33%) 16 (28%)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (59) (58) (57)
C-Cell, Adenoma 7 (12%) 5 (9%) 5 (9%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 3 (5%) 2 (4%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (3) (2) (2)
Lipoma 2 (100%)
Oral, Osteosarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (59) (58) (58)
Preputial Gland (59) (58) (58)
Adenoma 1 (2%) 3 (5%) 2 (3%)
Carcinoma 1 (2%)
Fibrous Histiocytoma 1 (2%)
Prostate (58) (58) (58)
Adenoma 1 (2%)
Seminal Vesicle (59) (58) (58)
Testes (59) (58) (58)
Bilateral, Interstitial Cell, Adenoma 20 (34%) 36 (62%) 27 (47%)
Interstitial Cell, Adenoma 23 (39%) 14 (24%) 16 (28%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (58) (58)
Lymph Node (16) (19) (16) (1)
Lymph Node, Bronchial (57) (6) (56) (7) (58) (7)
Lymph Node, Mandibular (54) (56) (55)
Squamous Cell Carcinoma, Metastatic 1 (2%)
Lymph Node, Mesenteric (59) (58) (58)
Page 12
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Lymph Node, Mediastinal (52) (6) (57) (6) (57) (6)
Spleen (59) (58) (58)
Fibrosarcoma 1 (2%)
Thymus (48) (53) (52)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (58) (58)
Fibroadenoma 2 (3%) 1 (2%)
Skin (13) (4) (14)
Basal Cell Adenoma 2 (15%) 1 (7%)
Fibroma 3 (23%) 1 (25%) 1 (7%)
Keratoacanthoma 1 (8%) 1 (25%) 1 (7%)
Lipoma 1 (7%)
Squamous Cell Carcinoma 1 (25%)
Squamous Cell Papilloma 1 (25%) 1 (7%)
Trichoepithelioma 1 (7%)
Scrotum, Fibroma 1 (7%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (8%)
Subcutaneous Tissue, Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59) (58) (58)
Pelvis, Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (58) (58)
Astrocytoma NOS 1 (2%)
Granular Cell Tumor NOS 1 (2%)
Peripheral Nerve (1)
Ganglion, Paraganglioma Benign 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (6) (58) (7) (58) (7)
Alveolar/Bronchiolar Adenoma 1 (2%) 3 (5%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Alveolar/Bronchiolar Carcinoma, Squamous
Differentiation 2 (3%)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 13
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Fibroma 1 (100%)
Eye (12) (5) (3)
Lids, Fibroma 1 (20%)
Harderian Gland (1)
Carcinoma 1 (100%)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (6) (58) (7) (58) (7)
Renal Tubule, Adenoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (59) (3) (58) (3) (58) (5)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(59) *(6) *(58) *(7) *(58) *(7)
Leukemia Mononuclear 31 (53%) 32 (55%) 26 (45%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 14
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/M3 0 MG/M3 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 57 57 56
Total Primary Neoplasms 158 162 162
Total Animals with Benign Neoplasms 56 55 55
Total Benign Neoplasms 118 122 119
Total Animals with Malignant Neoplasms 37 38 35
Total Malignant Neoplasms 40 39 42
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 3 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 15
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 58 7
Scheduled Sacrifice 5 7
Early Deaths
Moribund Sacrifice 36
Natural Death 4
Survivors
Natural Death 1
Terminal Sacrifice 11
Other 1
Animals Examined Microscopically 57 7
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (57)
Intestine Large, Cecum (56)
Intestine Small, Duodenum (57)
Intestine Small, Jejunum (57)
Intestine Small, Ileum (56)
Liver (57)
Fibrous Histiocytoma, Metastatic 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 2 (4%)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Mesentery (1)
Pancreas (57)
Salivary Glands (57)
Stomach, Forestomach (57)
Stomach, Glandular (57)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (57)
Carcinoma, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (57)
Adrenal Medulla (57)
Pheochromocytoma Malignant 6 (11%)
Pheochromocytoma Benign 16 (28%)
Page 16
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Bilateral, Pheochromocytoma Benign 16 (28%)
Islets, Pancreatic (57)
Adenoma 2 (4%)
Parathyroid Gland (54)
Pituitary Gland (57)
Pars Distalis, Adenoma 12 (21%)
Thyroid Gland (57)
C-Cell, Adenoma 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4)
Basal Cell Carcinoma 1 (25%)
Carcinoma, Metastatic, Lung 1 (25%)
Fibrosarcoma 1 (25%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (57)
Preputial Gland (56)
Adenoma 2 (4%)
Carcinoma 1 (2%)
Seminal Vesicle (57)
Testes (57)
Bilateral, Interstitial Cell, Adenoma 27 (47%)
Interstitial Cell, Adenoma 24 (42%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (15)
Lymph Node, Bronchial (57) (7)
Lymph Node, Mandibular (56)
Lymph Node, Mesenteric (56)
Lymph Node, Mediastinal (56) (6)
Spleen (57)
Pheochromocytoma Malignant, Metastatic 1 (2%)
Thymus (53)
Carcinoma, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
Page 17
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (57)
Skin (7)
Keratoacanthoma 1 (14%)
Papilloma 1 (14%)
Sebaceous Gland, Adenoma 1 (14%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (14%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Fibrous Histiocytoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Peripheral Nerve (1)
Ganglion, Paraganglioma Benign 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (57) (7)
Alveolar/Bronchiolar Adenoma 2 (4%)
Alveolar/Bronchiolar Carcinoma 2 (4%)
Fibrous Histiocytoma, Metastatic 1 (2%)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Pheochromocytoma Malignant, Metastatic 1 (2%)
Nose (57) (7)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (57) (7)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Urinary Bladder (57) (4)
Page 18
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(57) *(7)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 35 (61%)
Mesothelioma Malignant 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 19
NTP Experiment-Test: 05123-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 04:33:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 2.5MG/M3 2.5MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 57
Total Primary Neoplasms 162
Total Animals with Benign Neoplasms 57
Total Benign Neoplasms 110
Total Animals with Malignant Neoplasms 43
Total Malignant Neoplasms 52
Total Animals with Metastatic Neoplasms 6
Total Metastatic Neoplasm 19
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 20
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