TDMS Study 05123-05 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
NICKEL OXIDE
NTP Experiment-Test: 05123-05 Report: PEIRPT09
Study Type: CHRONIC Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
2 YEAR CORE STUDY
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 001313991
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25026 Other 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Merge 002 002,004 0 MG/M3
Merge 006 006,008 0.62MGM3
Merge 010 010,012 1.25MGM3
Merge 014 014,016 2.5MG/M3
Merge 001 001,003 0 MG/M3
Merge 005 005,007 0.62MGM3
Merge 009 009,011 1.25MGM3
Merge 013 013,015 2.5MG/M3
Page 1
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|
DAY ON TEST | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|
| 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
| 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 3 1 1 3 1 1 1 1|
Congestion | |
Cyst | X |
Eosinophilic Focus | 1 |
Fatty Change | 2 1 1 2 1 2 4 2 1 2 1 |
Granuloma | |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X |
Pigmentation, Bile | 1 |
Pigmentation, Hemosiderin | 1 |
Bile Duct, Hyperplasia | 2 2 |
Hepatocyte, Hyperplasia | 2 2 3 |
Hepatocyte, Necrosis | 2 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +|
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
Edema | 3 |
Hyperkeratosis | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | X |
Vein, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Congestion | 1 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|
DAY ON TEST | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|
| 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
| 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | X |
Degeneration, Fatty | 2 |
Degeneration | 3 2 |
Hemorrhage | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + M + + + + + + + + M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Angiectasis | 4 2 2 1 1 |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 3 4 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 2 2 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 1|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +|
Fibrosis | 3 |
Hyperplasia | 3 3 3 3 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Pigmentation | 1 |
Iliac, Hyperplasia, Lymphoid | 4 |
Pancreatic, Inflammation, Chronic | |
Active | 4 |
Popliteal, Pigmentation | |
Renal, Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + M I +|
Congestion | 2 |
Hyperplasia, Lymphoid | 4 |
Pigmentation, Hemosiderin | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|
DAY ON TEST | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|
| 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
| 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + M + + + + + +|
Hyperplasia, Lymphoid | 3 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + A + +|
Congestion | |
Inflammation, Chronic Active | 4 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + I + + + + + + + + + + M + + + + + + + + M + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Infarct | |
__________________________________________________________________________|
Thymus | I + + + + + + I + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 3 2 4 |
Femur, Hyperostosis | 2 3 4|
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Cerebrum, Compression | X X |
Hypothalamus, Compression | X |
Ventricle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Inflammation, Chronic | 1 1 2 1 1 1 1|
Inflammation, Chronic Active | 3 |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|
DAY ON TEST | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|
| 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
| 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Atypical | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Hemorrhage | |
Inflammation, Suppurative | 3 |
Necrosis | 3 |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 2 2 1 1 2 3 1 2 2 2 2 1 2 1 2 2|
Cortex, Inflammation, Chronic | 3 |
Cortex, Necrosis, Acute | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|
| 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 1 1 1 1 3 2 1 3 1 1 1 1 1|
Congestion | 2 |
Cyst | |
Eosinophilic Focus | 1 |
Fatty Change | 2 4 1 2 1 2 3 3 2 |
Granuloma | 2 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | |
Pigmentation, Bile | |
Pigmentation, Hemosiderin | |
Bile Duct, Hyperplasia | 2 2 |
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | 1 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperkeratosis | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
Vein, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Atrophy | 4 |
Congestion | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|
| 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | |
Degeneration, Fatty | 1 |
Degeneration | |
Hemorrhage | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 |
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + I + + + + + + + + + +|
Angiectasis | 1 |
Pars Distalis, Angiectasis | 1 4 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 3 4 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 1 1 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 2 |
Hyperplasia | 3 2 3 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + +|
Pigmentation | |
Iliac, Hyperplasia, Lymphoid | |
Pancreatic, Inflammation, Chronic | |
Active | |
Popliteal, Pigmentation | 1|
Renal, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + M + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|
| 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + I + + + M + + M + + +|
Hyperplasia, Lymphoid | 3 |
Pigmentation | 2 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Inflammation, Chronic Active | |
Pigmentation | 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + M + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Infarct | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
Femur, Hyperostosis | 2 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Cerebrum, Compression | X X X |
Hypothalamus, Compression | X |
Ventricle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|
| 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Atypical | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Hemorrhage | |
Inflammation, Suppurative | |
Necrosis | |
Lens, Cataract | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 3 1 3 3 3 1 2 1 2 3 2 2 1 1 2 3|
Cortex, Inflammation, Chronic | |
Cortex, Necrosis, Acute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 2| 8| | |
| 2| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0 MG/M3 | 2| 2| 3| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 52 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Basophilic Focus | 1 1 | 26 1.4|
Congestion | 2 | 2 2.0|
Cyst | | 1 |
Eosinophilic Focus | | 2 1.0|
Fatty Change | 3 | 21 2.0|
Granuloma | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 7 |
Mixed Cell Focus | | 1 |
Pigmentation, Bile | | 1 1.0|
Pigmentation, Hemosiderin | | 1 1.0|
Bile Duct, Hyperplasia | | 4 2.0|
Hepatocyte, Hyperplasia | 3 | 4 2.5|
Hepatocyte, Necrosis | | 6 1.2|
__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
Acinus, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 52 |
Edema | | 1 3.0|
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 52 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Atrium, Thrombosis | | 1 |
Vein, Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 2| 8| | |
| 2| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0 MG/M3 | 2| 2| 3| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | | 1 1.0|
Atrophy | | 1 4.0|
Congestion | | 1 1.0|
Cyst | | 1 |
Degeneration, Fatty | | 2 1.5|
Degeneration | | 2 2.5|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 51 |
Angiectasis | | 3 1.0|
Hyperplasia | 1 1 | 8 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 52 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Angiectasis | | 1 1.0|
Pars Distalis, Angiectasis | | 7 2.1|
Pars Distalis, Cyst | X | 8 |
Pars Distalis, Hyperplasia | 3 | 9 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 6 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
Atrophy | | 1 2.0|
Ectasia | 2 | 5 2.0|
__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Cyst | | 5 |
__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Endometrium, Hyperplasia, Cystic | | 5 1.0|
__________________________________________________________________________|____________|
Vagina | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 52 |
Fibrosis | 2 | 5 1.8|
Hyperplasia | 2 3 | 14 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 2| 8| | |
| 2| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0 MG/M3 | 2| 2| 3| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation | | 1 1.0|
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Pancreatic, Inflammation, Chronic | | |
Active | | 1 4.0|
Popliteal, Pigmentation | | 1 1.0|
Renal, Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 49 |
Congestion | | 2 2.5|
Hyperplasia, Lymphoid | | 1 4.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 47 |
Hyperplasia, Lymphoid | 3 | 3 3.0|
Pigmentation | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 51 |
Congestion | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
Pigmentation | | 4 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 48 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Fibrosis | | 1 4.0|
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + | 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
__________________________________________________________________________|____________|
Skin | | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
Osteopetrosis | | 4 3.0|
Femur, Hyperostosis | | 5 2.6|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 2| 8| | |
| 2| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0 MG/M3 | 2| 2| 3| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Hemorrhage | | 1 1.0|
Cerebrum, Compression | | 5 |
Hypothalamus, Compression | | 2 |
Ventricle, Dilatation | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
Inflammation, Chronic | | 4 1.5|
Inflammation, Chronic Active | 1 | 3 1.0|
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Congestion | | 1 1.0|
Inflammation, Chronic | 1 | 18 1.1|
Inflammation, Chronic Active | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Atypical | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
Necrosis | | 1 3.0|
Lens, Cataract | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Nephropathy | 1 2 | 36 1.8|
Cortex, Inflammation, Chronic | | 1 3.0|
Cortex, Necrosis, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|
| 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 2 3 1 1 2 1 1 1 2 1 2 1 1 2 1 2 1 |
Clear Cell Focus | 1 |
Congestion | 1 |
Degeneration, Cystic | 1 |
Eosinophilic Focus | |
Fatty Change | 2 2 1 1 2 2 1|
Fibrosis | 1 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | X X |
Pigmentation, Bile | 2 |
Pigmentation, Hemosiderin | |
Bile Duct, Hyperplasia | 2 |
Hepatocyte, Hyperplasia | 3 2 |
Hepatocyte, Necrosis | 2 2 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Polyarteritis | |
Mesenteric Artery, Polyarteritis | |
Mesenteric Artery, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|
| 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | 2 |
Congestion | 2 |
Degeneration, Fatty | 4 |
Hyperplasia | |
Bilateral, Angiectasis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | 2 |
Hyperplasia | 2 1 3 3 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + M + + + + + + + + + + + M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Cyst | X X X X X|
Pars Distalis, Degeneration | |
Pars Distalis, Hyperplasia | 3 3 3 3 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | |
Pars Intermedia, Hypertrophy | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 2 |
Hyperplasia, Cystic | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Hyperplasia | 4 4 2 3 3 3|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|
| 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + |
Hyperplasia, Lymphoid | 1 |
Renal, Congestion | 1 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + M + + + M I + + + +|
Congestion | |
Edema | 1|
Hyperplasia, Lymphoid | 1 2 |
Hyperplasia, Macrophage | 3 |
Pigmentation | 1 1 1 2 2 2 1 2 2 2 1 2 2 1 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + M + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + I + + + M M + M + + + + + M + M +|
Congestion | 2 2 |
Hyperplasia, Lymphoid | 1 2 2 2 |
Pigmentation | 1 1 2 1 2 2 1 1 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | |
Infarct | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + I + M + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | |
__________________________________________________________________________|
Skin | + |
Inflammation, Suppurative | 4 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 4 2|
Femur, Hyperostosis | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Compression | X |
Cerebrum, Compression | X X X |
Hypothalamus, Compression | |
Ventricle, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|
| 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 2 1 2 2 2 1 2 2 1 2 2 2 2 2 2 1 2 2 2 2 2|
Alveolar Epithelium, Hyperplasia, | |
Atypical | 2 |
Alveolus, Pigmentation | 1 2 1 1 2 1 2 2 2 1 2 2 1 2 2 2 2 2 2 2 2 2 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 1 3 2 1 1 3 3 2 1 1 1 2 2 2 3 2 1 2 1 1|
Cortex, Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|
| 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Basophilic Focus | 2 1 1 1 1 3 1 2 1 1 2 1 2 2 1 1 |
Clear Cell Focus | |
Congestion | |
Degeneration, Cystic | |
Eosinophilic Focus | 1 1 |
Fatty Change | 1 3 3 1 3 2 1 2 2 3 1 |
Fibrosis | |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X |
Pigmentation, Bile | |
Pigmentation, Hemosiderin | 2 |
Bile Duct, Hyperplasia | 1 2 |
Hepatocyte, Hyperplasia | 2 3 2 2|
Hepatocyte, Necrosis | 1 2 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Ulcer | 3 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Polyarteritis | 4 |
Mesenteric Artery, Polyarteritis | X |
Mesenteric Artery, Thrombosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|
| 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | 1 2 |
Congestion | 2 |
Degeneration, Fatty | 2 2 |
Hyperplasia | 3 |
Bilateral, Angiectasis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Hyperplasia | 4 2 1 4 3 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + I + + + + + + + M + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Angiectasis | 2 2 2 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Degeneration | 1 |
Pars Distalis, Hyperplasia | 3 2 2 4 2 4|
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | X |
Pars Intermedia, Hypertrophy | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Cystic | 3 |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Endometrium, Hyperplasia, Cystic | 3 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 |
Hyperplasia | 3 2 2 2 2 2 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|
| 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Hyperplasia, Lymphoid | |
Renal, Congestion | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Edema | |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Macrophage | |
Pigmentation | 1 1 1 2 2 2 2 1 2 1 1 2 1 2 1 2 2 2 2 1 1 1 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | I + + + + + + + + + + + M + + M M + + + + + + + I|
Congestion | |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + M +|
Congestion | 3 1 4 |
Hyperplasia, Lymphoid | 2 1 2 2 2 |
Pigmentation | 2 1 1 2 2 1 2 2 1 1 1 2 1 1 2 2 1 1 2 1 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 4 |
Infarct | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 2 |
__________________________________________________________________________|
Skin | + + |
Inflammation, Suppurative | |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Compression | |
Cerebrum, Compression | X |
Hypothalamus, Compression | X |
Ventricle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|
| 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.62MGM3 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 2 1 2 1 1 1 2 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2|
Alveolar Epithelium, Hyperplasia, | |
Atypical | |
Alveolus, Pigmentation | 2 1 2 2 2 1 1 1 2 1 1 2 2 2 2 2 1 2 2 2 1 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 4 3 1 2 2 1 3 1 1 2 2 2 2 2 1 1 3 2|
Cortex, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| | |
| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.62MGM3 | 5| 5| 5| | L |
| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | | 2 1.0|
Basophilic Focus | 1 1 1 | 38 1.4|
Clear Cell Focus | | 1 1.0|
Congestion | | 1 1.0|
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | 1 | 3 1.0|
Fatty Change | | 18 1.8|
Fibrosis | | 1 1.0|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | | 3 |
Pigmentation, Bile | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Bile Duct, Hyperplasia | | 3 1.7|
Hepatocyte, Hyperplasia | | 6 2.3|
Hepatocyte, Necrosis | | 7 1.6|
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Atrophy | | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + M | 52 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Hyperkeratosis | | 1 3.0|
Ulcer | | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Erosion | | 1 1.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Polyarteritis | | 1 4.0|
Mesenteric Artery, Polyarteritis | | 1 |
Mesenteric Artery, Thrombosis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| | |
| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.62MGM3 | 5| 5| 5| | L |
| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | | 3 1.7|
Congestion | | 2 2.0|
Degeneration, Fatty | | 3 2.7|
Hyperplasia | | 1 3.0|
Bilateral, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 52 |
Angiectasis | | 1 2.0|
Congestion | | 1 2.0|
Hyperplasia | | 12 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 47 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Angiectasis | | 1 2.0|
Pars Distalis, Angiectasis | 2 | 6 2.2|
Pars Distalis, Cyst | | 8 |
Pars Distalis, Degeneration | | 1 1.0|
Pars Distalis, Hyperplasia | 1 | 11 2.7|
Pars Intermedia, Angiectasis | | 1 2.0|
Pars Intermedia, Cyst | | 1 |
Pars Intermedia, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
Ectasia | 2 | 3 2.7|
Hyperplasia, Cystic | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| | |
| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.62MGM3 | 5| 5| 5| | L |
| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 5 |
__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Dilatation | | 1 3.0|
Endometrium, Hyperplasia, Cystic | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Fibrosis | | 3 2.3|
Hyperplasia | | 15 2.6|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 6 |
Hyperplasia, Lymphoid | | 1 1.0|
Renal, Congestion | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 50 |
Congestion | | 2 2.0|
Edema | | 1 1.0|
Hyperplasia, Lymphoid | 1 | 5 1.6|
Hyperplasia, Macrophage | | 1 3.0|
Pigmentation | 2 2 1 | 43 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M | 45 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 46 |
Congestion | | 5 2.4|
Hyperplasia, Lymphoid | | 9 1.8|
Pigmentation | 2 2 1 | 34 1.5|
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Fibrosis | | 3 1.7|
Hematopoietic Cell Proliferation | | 1 4.0|
Infarct | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + | 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Hyperplasia, Glandular | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| | |
| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.62MGM3 | 5| 5| 5| | L |
| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | | 3 |
Inflammation, Suppurative | | 1 4.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
Osteopetrosis | | 2 3.0|
Femur, Hyperostosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Cerebellum, Compression | | 1 |
Cerebrum, Compression | | 4 |
Hypothalamus, Compression | | 1 |
Ventricle, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
Inflammation, Chronic Active | | 2 1.5|
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Inflammation, Chronic | 2 2 2 | 52 1.7|
Alveolar Epithelium, Hyperplasia, | | |
Atypical | | 1 2.0|
Alveolus, Pigmentation | 2 2 2 | 52 1.7|
__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Nephropathy | 2 3 1 | 43 1.9|
Cortex, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|
DAY ON TEST | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|
| 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + I +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 3 2 1 1 1 1 2 2 1 2 1 2 3 3 1|
Congestion | 2 |
Degeneration, Cystic | |
Eosinophilic Focus | 1 1 1 |
Fatty Change | 3 3 2 2 2 |
Hepatodiaphragmatic Nodule | X X X X X X|
Thrombosis | X |
Bile Duct, Hyperplasia | 2 4 |
Hepatocyte, Hyperplasia | 2 |
Hepatocyte, Necrosis | 1 3 |
Portal Vein, Thrombosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Artery, Mineralization | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + I + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 2 4 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 3 |
Mineralization | 2 |
Ulcer | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Mineralization | 4 |
Vena Cava, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|
DAY ON TEST | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|
| 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Ventricle, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Congestion | 2 |
Degeneration, Fatty | 1 2 1 1 |
Edema | 2 |
Hemorrhage | 3 |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 1 2 4 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 3 |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hyperplasia | 2 3 2 |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Ectasia | 1 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + I + + + + + + + + + + + + +|
Cyst | |
Prolapse | |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 |
Hyperplasia | 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Pancreatic, Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|
DAY ON TEST | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|
| 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 3 |
Hyperplasia, Lymphoid | 1 1 2 2 1 2 1 2 2 2|
Pigmentation | 2 2 1 1 2 2 2 2 2 2 2 1 1 2 1 2 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + M + + + M +|
Congestion | 2 3 3 |
Ectasia | 3 |
Edema | 2 |
Hyperplasia, Lymphoid | 2 2 2 2 1 3 1 |
Hyperplasia, Plasma Cell | |
Pigmentation, Hemosiderin | 2 |
Pigmentation | 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + M + + + M + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Femur, Hyperostosis | 4 3 4 2 3 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Compression | |
Cerebrum, Compression | X |
Cerebrum, Ventricle, Dilatation | 2 1|
Hypothalamus, Compression | X X |
Pons, Compression | X |
Ventricle, Dilatation | |
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|
DAY ON TEST | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|
| 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Inflammation, Chronic | 3 2 3 2 2 3 3 2 2 2 2 2 2 3 3 2 2 3 2 2 3 3 3 3 3|
Mineralization | 3 |
Alveolar Epithelium, Hyperplasia, | |
Atypical | 1 2 |
Alveolus, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 1 1 2 3 2 2 3 2 3 2 3 3 2 2|
Pleura, Fibrosis | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 4 2 |
Synechia | 4 |
Bilateral, Cornea, Edema | |
Cornea, Edema | 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy | 1 1 2 1 1 2 1 2 2 2 1 1 2 4 2 1 3 4 3 1|
Pelvis, Dilatation | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Edema | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|
DAY ON TEST | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|
| 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 1 2 1 1 1 1 1 1 1 1 2 |
Congestion | 1 2 |
Degeneration, Cystic | 1 3 |
Eosinophilic Focus | |
Fatty Change | 2 2 3 1 2 1 3 2 |
Hepatodiaphragmatic Nodule | X X X |
Thrombosis | |
Bile Duct, Hyperplasia | |
Hepatocyte, Hyperplasia | 2 |
Hepatocyte, Necrosis | 1 |
Portal Vein, Thrombosis | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Artery, Mineralization | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mineralization | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
Vena Cava, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|
DAY ON TEST | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|
| 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Ventricle, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Congestion | 2 |
Degeneration, Fatty | 3 |
Edema | |
Hemorrhage | |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 4 4 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Cyst | X X X X|
Pars Distalis, Hyperplasia | 3 2 2 |
Pars Intermedia, Angiectasis | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 4 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Prolapse | X |
Endometrium, Hyperplasia, Cystic | 2 1 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hyperplasia | 2 3 2 2 2 3 2 1 |
__________________________________________________________________________|
Lymph Node | + + + |
Pancreatic, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|
DAY ON TEST | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|
| 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Edema | |
Hyperplasia, Lymphoid | 1 2 2 2 1 1 1 1 1|
Pigmentation | 2 2 2 2 1 2 2 1 1 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 1 1 |
Ectasia | |
Edema | |
Hyperplasia, Lymphoid | 2 2 2 2 3 3 1 |
Hyperplasia, Plasma Cell | 2 |
Pigmentation, Hemosiderin | |
Pigmentation | 2 2 2 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Thymus | + + M + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + +|
Subcutaneous Tissue, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 |
Femur, Hyperostosis | 2 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Compression | X |
Cerebrum, Compression | X X |
Cerebrum, Ventricle, Dilatation | |
Hypothalamus, Compression | X |
Pons, Compression | |
Ventricle, Dilatation | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|
DAY ON TEST | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|
| 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 3 2 |
Inflammation, Chronic | 3 2 2 2 2 2 3 2 2 3 2 2 2 2 2 2 3 2 3 2 2 2 2 3 2|
Mineralization | |
Alveolar Epithelium, Hyperplasia, | |
Atypical | 2 4 3 3 |
Alveolus, Pigmentation | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2|
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Synechia | |
Bilateral, Cornea, Edema | |
Cornea, Edema | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 2 2 3 2 2 3 2 2 2 1 1 1 2 1 3 |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Edema | 3 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 5| 6| 4| | |
DAY ON TEST | 1| 2| 3| | |
| 4| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 8| 8| 8| | L |
| 6| 7| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
Mineralization | | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 27 1.5|
Congestion | | 3 1.7|
Degeneration, Cystic | | 2 2.0|
Eosinophilic Focus | | 3 1.0|
Fatty Change | 3 2 1 | 16 2.1|
Hepatodiaphragmatic Nodule | | 9 |
Thrombosis | | 1 |
Bile Duct, Hyperplasia | 2 | 3 2.7|
Hepatocyte, Hyperplasia | 2 | 3 2.0|
Hepatocyte, Necrosis | | 3 1.7|
Portal Vein, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Atrophy | | 1 1.0|
Artery, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Hyperkeratosis | | 4 2.8|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
Mineralization | | 1 2.0|
Ulcer | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Erosion | | 1 2.0|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 5| 6| 4| | |
DAY ON TEST | 1| 2| 3| | |
| 4| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 8| 8| 8| | L |
| 6| 7| 9| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Aorta, Mineralization | | 1 4.0|
Vena Cava, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Atrium, Thrombosis | | 1 |
Ventricle, Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | | 3 2.0|
Congestion | | 2 2.0|
Degeneration, Fatty | | 5 1.6|
Edema | | 1 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Hyperplasia | 2 | 14 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Pars Distalis, Angiectasis | | 6 2.3|
Pars Distalis, Cyst | X | 11 |
Pars Distalis, Hyperplasia | | 6 2.3|
Pars Intermedia, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Hyperplasia | | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + | 51 |
Ectasia | 2 | 5 2.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Cyst | | 7 |
__________________________________________________________________________|____________|
Uterus | + + + | 52 |
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 5| 6| 4| | |
DAY ON TEST | 1| 2| 3| | |
| 4| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 8| 8| 8| | L |
| 6| 7| 9| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Prolapse | | 1 |
Endometrium, Hyperplasia, Cystic | | 2 1.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Fibrosis | | 3 2.3|
Hyperplasia | 2 | 15 2.1|
__________________________________________________________________________|____________|
Lymph Node | + | 9 |
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 53 |
Congestion | | 1 2.0|
Edema | | 1 3.0|
Hyperplasia, Lymphoid | 1 | 20 1.5|
Pigmentation | 2 2 2 | 52 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
Hyperplasia, Lymphoid | | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + | 48 |
Congestion | | 7 2.1|
Ectasia | | 1 3.0|
Edema | | 1 2.0|
Hyperplasia, Lymphoid | | 14 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Pigmentation | 1 | 39 1.8|
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Fibrosis | | 3 2.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Capsule, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + | 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
__________________________________________________________________________|____________|
Skin | | 3 |
Subcutaneous Tissue, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 5| 6| 4| | |
DAY ON TEST | 1| 2| 3| | |
| 4| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 8| 8| 8| | L |
| 6| 7| 9| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
Hyperostosis | 4 | 2 2.5|
Femur, Hyperostosis | 2 2 | 10 2.9|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Cerebellum, Compression | | 1 |
Cerebrum, Compression | | 3 |
Cerebrum, Ventricle, Dilatation | | 2 1.5|
Hypothalamus, Compression | | 3 |
Pons, Compression | | 1 |
Ventricle, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
Inflammation, Chronic | | 2 1.5|
Inflammation, Chronic Active | | 2 2.0|
Inflammation, Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Congestion | | 1 3.0|
Hemorrhage | | 2 2.5|
Inflammation, Chronic | 3 3 2 | 53 2.4|
Mineralization | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Atypical | | 6 2.5|
Alveolus, Pigmentation | 2 2 2 | 53 2.1|
Pleura, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + | 52 |
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
Inflammation, Chronic Active | | 2 2.0|
Inflammation, Suppurative | | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
Cataract | | 2 3.0|
Synechia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 5| 6| 4| | |
DAY ON TEST | 1| 2| 3| | |
| 4| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 8| 8| 8| | L |
| 6| 7| 9| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Bilateral, Cornea, Edema | 1 | 1 1.0|
Cornea, Edema | | 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Cyst | X | 2 |
Nephropathy | | 35 1.9|
Pelvis, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Calculus Micro Observation Only | | 1 |
Edema | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 0| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 7| 3| 9| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9|
| 2| 1| 2| 0| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 1 1 1 2 2 4 1 4 1 1 1 2 2 1 1 |
Degeneration, Cystic | |
Eosinophilic Focus | |
Fatty Change | 1 1 2 1 2 2|
Hepatodiaphragmatic Nodule | X X X|
Inflammation, Chronic | |
Pigmentation, Bile | 2 |
Bile Duct, Hyperplasia | |
Hepatocyte, Hyperplasia | 2 3 2 1 |
Hepatocyte, Necrosis | 2 1 1 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Inflammation, Chronic | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 3 2 |
Degeneration, Fatty | 1 3 1 2 2 |
Edema | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +|
Angiectasis | 2 |
Hyperplasia | 2 4 2 2 1 2 4 1 2 3 4 1 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 0| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 7| 3| 9| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9|
| 2| 1| 2| 0| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 1 |
Pars Distalis, Cyst | X X X X X|
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 2 3 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Ectasia | 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Fibrosis | 3 |
Hemorrhage | 2 |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Endometrium, Hyperplasia, Cystic | 2 3 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + |
Renal, Edema | 3 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 1 3 2 1 |
Hyperplasia, Macrophage | 2 |
Pigmentation | 2 2 2 2 1 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + M + + +|
Hyperplasia, Lymphoid | 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 1 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 0| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 7| 3| 9| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9|
| 2| 1| 2| 0| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 1 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + + + + + + + + + + + + + + + M + M|
Congestion | |
Edema | 2 |
Hyperplasia, Lymphoid | 2 2 2 |
Pigmentation | 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 3 4 2 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Compression | X X |
Cerebrum, Ventricle, Dilatation | 2 2 |
Hypothalamus, Compression | X X |
Ventricle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X |
Hemorrhage | |
Inflammation, Chronic | 2 3 2 2 2 3 2 2 3 2 2 2 2 2 2 3 2 3 3 3 2 2 3 2 3|
Alveolar Epithelium, Hyperplasia, | |
Atypical | 2 1 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Pigmentation | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 0| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 7| 3| 9| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9|
| 2| 1| 2| 0| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 2 3 1 3 2 1 2 1 2 2 2 2 1 2 1 1 |
Pelvis, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3|
| 1| 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.5MG/M3 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 2 1 3 1 1 1 1 2 3 1 1 1 1 1 1 2|
Degeneration, Cystic | |
Eosinophilic Focus | 1 1 |
Fatty Change | 2 1 1 1 1 2 2 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 |
Pigmentation, Bile | |
Bile Duct, Hyperplasia | 2 |
Hepatocyte, Hyperplasia | 2 1 2 |
Hepatocyte, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + I + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 1 2 |
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Degeneration, Fatty | 2 1 1 |
Edema | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 3 3 1 3 2 4 3 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3|
| 1| 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.5MG/M3 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hemorrhage | 3 2 |
Pars Distalis, Hyperplasia | 4 2 4 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + M + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Fibrosis | |
Hemorrhage | |
Bilateral, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Endometrium, Hyperplasia, Cystic | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 2 2 1 2 2 2 2 4|
__________________________________________________________________________|
Lymph Node | +|
Renal, Edema | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + M + + + + + + +|
Congestion | 2 3 |
Hyperplasia, Lymphoid | 2 2 1 1 1 1 2 |
Hyperplasia, Macrophage | |
Pigmentation | 2 2 2 2 1 2 1 2 2 2 1 2 1 2 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + M M +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3|
| 1| 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.5MG/M3 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + I + + + + + + + + + + + + + + + +|
Congestion | 4 |
Edema | |
Hyperplasia, Lymphoid | 2 2 2 1 3 1 2 3 3 |
Pigmentation | 2 2 2 2 2 1 1 2 2 2 2 2 1 2 2 2 2 2 1 2 2 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 4 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + M + + + M + + M + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 3 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Compression | X X |
Cerebrum, Ventricle, Dilatation | 2 2 2 |
Hypothalamus, Compression | X X |
Ventricle, Dilatation | 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Cyst | |
Hemorrhage | 4 4 |
Inflammation, Chronic | 3 3 3 2 2 2 2 2 3 3 3 3 2 2 3 3 3 3 3 2 2 2 2 2 3|
Alveolar Epithelium, Hyperplasia, | |
Atypical | 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Pigmentation | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3|
| 1| 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.5MG/M3 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 3 1 1 1 1 2 1 2 1 2 2 1 3 3 3 2 3 1|
Pelvis, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| | |
DAY ON TEST | 9| 0| 0| 3| | |
| 4| 7| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| | A |
2.5MG/M3 | 1| 1| 1| 2| | L |
| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 54 |
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 54 |
__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Angiectasis | | 1 3.0|
Basophilic Focus | 1 1 | 34 1.5|
Degeneration, Cystic | 1 | 1 1.0|
Eosinophilic Focus | | 2 1.0|
Fatty Change | 2 | 15 1.5|
Hepatodiaphragmatic Nodule | | 4 |
Inflammation, Chronic | | 1 1.0|
Pigmentation, Bile | | 1 2.0|
Bile Duct, Hyperplasia | | 1 2.0|
Hepatocyte, Hyperplasia | 3 | 8 2.0|
Hepatocyte, Necrosis | | 4 1.5|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
Hyperkeratosis | | 4 1.5|
Inflammation, Chronic | | 1 3.0|
Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 54 |
Inflammation, Chronic | | 1 2.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 54 |
Congestion | | 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| | |
DAY ON TEST | 9| 0| 0| 3| | |
| 4| 7| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| | A |
2.5MG/M3 | 1| 1| 1| 2| | L |
| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Degeneration, Fatty | | 8 1.6|
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 53 |
Angiectasis | | 1 2.0|
Hyperplasia | 4 | 22 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 54 |
Pars Distalis, Angiectasis | 2 | 5 2.2|
Pars Distalis, Cyst | X | 9 |
Pars Distalis, Hemorrhage | | 2 2.5|
Pars Distalis, Hyperplasia | | 12 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 53 |
C-Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + | 50 |
Ectasia | | 4 2.0|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + | 54 |
Cyst | | 3 |
Fibrosis | | 1 3.0|
Hemorrhage | | 1 2.0|
Bilateral, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + | 54 |
Dilatation | | 1 4.0|
Endometrium, Hyperplasia, Cystic | | 7 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
Fibrosis | 1 | 1 1.0|
Hyperplasia | 3 2 2 | 16 2.1|
__________________________________________________________________________|____________|
Lymph Node | | 3 |
Renal, Edema | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| | |
DAY ON TEST | 9| 0| 0| 3| | |
| 4| 7| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| | A |
2.5MG/M3 | 1| 1| 1| 2| | L |
| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + | 52 |
Congestion | | 2 2.5|
Hyperplasia, Lymphoid | 3 2 | 13 1.7|
Hyperplasia, Macrophage | | 1 2.0|
Pigmentation | 2 2 2 2 | 47 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 49 |
Hyperplasia, Lymphoid | | 3 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 54 |
Hyperplasia, Lymphoid | | 3 2.0|
Pigmentation | | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + | 50 |
Congestion | | 1 4.0|
Edema | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 | 14 2.1|
Pigmentation | 2 2 2 | 44 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + | 54 |
Fibrosis | 1 | 1 1.0|
Hyperplasia | 3 | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + + + | 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 54 |
__________________________________________________________________________|____________|
Skin | | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 54 |
Femur, Hyperostosis | 1 | 8 2.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 54 |
Cerebrum, Compression | X | 5 |
Cerebrum, Ventricle, Dilatation | | 5 2.0|
Hypothalamus, Compression | X | 5 |
Ventricle, Dilatation | | 3 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 54 |
Inflammation, Chronic | | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| | |
DAY ON TEST | 9| 0| 0| 3| | |
| 4| 7| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| | A |
2.5MG/M3 | 1| 1| 1| 2| | L |
| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Congestion | | 1 4.0|
Cyst | | 1 |
Hemorrhage | | 2 4.0|
Inflammation, Chronic | 2 2 2 2 | 54 2.4|
Alveolar Epithelium, Hyperplasia, | | |
Atypical | | 5 1.4|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolus, Pigmentation | 2 2 2 2 | 54 2.0|
__________________________________________________________________________|____________|
Nose | + + + + | 54 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 2 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 54 |
Nephropathy | 2 3 | 40 1.8|
Pelvis, Cyst | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|
DAY ON TEST | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|
| 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 2 1 1 3 1 1 1|
Clear Cell Focus | |
Degeneration, Cystic | 1 2 2 2 2 1 1 3 2 1|
Eosinophilic Focus | 1 |
Fatty Change | 1 1 2 1 3 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Suppurative | 2 |
Pigmentation, Bile | |
Thrombosis | |
Thrombosis, Multiple | |
Bile Duct, Hyperplasia | 3 2 2 2 1|
Hepatocyte, Hyperplasia | 2 1|
Hepatocyte, Necrosis | 1|
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Acinus, Atrophy | 2 1 1 |
Acinus, Fibrosis | |
Acinus, Hyperplasia | 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Suppurative | 2 |
Ulcer | |
Ulcer, Multiple | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Mineralization | 2 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|
DAY ON TEST | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|
| 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | X |
Myocardium, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 4 |
Hyperplasia | 4 2 1 2 2 1 2 4 1 4 2 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + + + + + + + + M + M + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Oral, Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Inflammation, Chronic | |
Inflammation, Suppurative | 1 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 1 |
Inflammation, Suppurative | 2 3 2 |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 4 4 2 3 3|
Interstitial Cell, Hyperplasia | 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|
DAY ON TEST | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|
| 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 1 2 |
Hyperplasia | 2 4 4 3 3 4 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + I + + + + + + + + + + + + + + I|
Congestion | |
Hyperplasia, Macrophage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Lymphoid | 2 4 3 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M I + + M + + + + + M + + + + + + + + + + + + M +|
Congestion | |
Ectasia | |
Hyperplasia, Lymphoid | 2 2 3 3|
Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 2 1 1 2 2 3 2 1 |
Infarct | |
__________________________________________________________________________|
Thymus | + M + + + + + + M + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 4 |
Pigmentation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Degeneration | |
Cerebrum, Necrosis | |
Hypothalamus, Compression | X X X |
Pons, Compression | X |
Thalamus, Degeneration | |
Ventricle, Dilatation | |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|
DAY ON TEST | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|
| 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + I + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 1 1 1 2 |
Mineralization | 2 |
Alveolus, Pigmentation | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + |
Cataract | 3 1 4 |
Anterior Chamber, Cornea, | |
Inflammation, Suppurative | 4 |
Bilateral, Cornea, Edema | 2 |
Cornea, Edema | |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Nephropathy | 3 3 2 4 3 2 4 3 3 2 3 3 1 2 2 2 3 1 2 4 1 2|
Bilateral, Nephropathy | 4 |
Cortex, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|
DAY ON TEST | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|
| 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 1 1 1 1 1|
Clear Cell Focus | 1 |
Degeneration, Cystic | 2 1 1 3 2 |
Eosinophilic Focus | |
Fatty Change | 4 1 2 1 1 3 1 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Suppurative | |
Pigmentation, Bile | 1 |
Thrombosis | X |
Thrombosis, Multiple | X X |
Bile Duct, Hyperplasia | 2 2 3 2 2 2 3 2 2 2 2 |
Hepatocyte, Hyperplasia | 2 2 2 2 |
Hepatocyte, Necrosis | 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Acinus, Atrophy | 2 1 |
Acinus, Fibrosis | 4 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Suppurative | |
Ulcer | 3 |
Ulcer, Multiple | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Ulcer | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 3 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|
DAY ON TEST | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|
| 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | X X |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Hyperplasia | 4 2 2 1 1 2 4 2 4 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Oral, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 3 |
Ectasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 |
Interstitial Cell, Hyperplasia | 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|
DAY ON TEST | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|
| 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 2 2 2 1 2 |
Hyperplasia | 4 4 3 4 4 3 3 3 3 4 3 4 4 4 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + M + + + + + + + + + M + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + M + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Ectasia | 2 |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Plasma Cell | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 1 2 |
Infarct | 4 2 2 1 |
__________________________________________________________________________|
Thymus | + M + + + I + + + + I I M + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | |
Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Degeneration | 2 |
Cerebrum, Necrosis | 4 |
Hypothalamus, Compression | X X X X X|
Pons, Compression | X |
Thalamus, Degeneration | 1 |
Ventricle, Dilatation | 2 3|
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|
DAY ON TEST | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|
| 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 2 1 1 1 1|
Mineralization | |
Alveolus, Pigmentation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | |
Anterior Chamber, Cornea, | |
Inflammation, Suppurative | |
Bilateral, Cornea, Edema | |
Cornea, Edema | 1 |
Sclera, Metaplasia, Osseous | 1 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 3 3 3 3 2 1 3 1 4 2 1 2 2 3 1 2 2 2 3 4 2|
Bilateral, Nephropathy | |
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 6| 7| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| | L |
| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 54 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 54 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 54 |
__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Basophilic Focus | 2 1 1 | 21 1.2|
Clear Cell Focus | | 1 1.0|
Degeneration, Cystic | 2 | 16 1.8|
Eosinophilic Focus | 1 1 | 3 1.0|
Fatty Change | | 13 1.8|
Hepatodiaphragmatic Nodule | | 4 |
Inflammation, Suppurative | | 1 2.0|
Pigmentation, Bile | | 1 1.0|
Thrombosis | | 1 |
Thrombosis, Multiple | | 2 |
Bile Duct, Hyperplasia | 2 | 17 2.1|
Hepatocyte, Hyperplasia | 2 2 | 8 1.9|
Hepatocyte, Necrosis | | 8 1.1|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
Atrophy | | 1 2.0|
Acinus, Atrophy | | 5 1.4|
Acinus, Fibrosis | | 1 4.0|
Acinus, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
Edema | 3 | 3 2.3|
Inflammation, Suppurative | | 1 2.0|
Ulcer | | 1 3.0|
Ulcer, Multiple | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
Inflammation, Suppurative | | 1 2.0|
Ulcer | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 6| 7| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| | L |
| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Aorta, Mineralization | | 2 3.0|
__________________________________________________________________________|____________|
Heart | + + + + | 54 |
Inflammation, Suppurative | | 2 2.0|
Atrium, Thrombosis | X | 4 |
Myocardium, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 54 |
Degeneration, Fatty | 3 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 54 |
Degeneration, Fatty | | 1 4.0|
Hyperplasia | 3 1 | 25 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 50 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 53 |
Angiectasis | 2 | 2 2.0|
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 4 | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 54 |
C-Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Oral, Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 4 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + | 54 |
Spermatocele | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 54 |
Ectasia | | 2 2.0|
Inflammation, Suppurative | | 3 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + | 53 |
Inflammation, Chronic | | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 6| 7| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| | L |
| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 3 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 54 |
Atrophy | | 3 2.3|
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + | 54 |
Atrophy | 4 | 11 3.4|
Interstitial Cell, Hyperplasia | | 7 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
Fibrosis | | 7 1.7|
Hyperplasia | 3 | 24 3.3|
__________________________________________________________________________|____________|
Lymph Node | + | 16 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + | 52 |
Congestion | | 1 2.0|
Hyperplasia, Macrophage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M | 49 |
Hyperplasia, Lymphoid | | 5 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 54 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + | 47 |
Congestion | | 1 1.0|
Ectasia | | 1 2.0|
Hyperplasia, Lymphoid | | 5 2.2|
Hyperplasia, Plasma Cell | | 3 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + | 54 |
Developmental Malformation | X | 1 |
Fibrosis | 3 | 11 1.8|
Infarct | | 4 2.3|
__________________________________________________________________________|____________|
Thymus | + + M + | 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 54 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + | 13 |
Cyst Epithelial Inclusion | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 6| 7| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| | L |
| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | | 1 4.0|
Pigmentation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 54 |
Cerebrum, Degeneration | | 1 2.0|
Cerebrum, Necrosis | | 1 4.0|
Hypothalamus, Compression | | 8 |
Pons, Compression | | 2 |
Thalamus, Degeneration | | 1 1.0|
Ventricle, Dilatation | | 2 2.5|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 52 |
Inflammation, Chronic | | 2 1.0|
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Inflammation, Chronic | 1 1 1 | 28 1.1|
Mineralization | | 1 2.0|
Alveolus, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + | 54 |
Inflammation, Chronic Active | 1 | 1 1.0|
Inflammation, Suppurative | | 5 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + | 53 |
Inflammation, Focal, Suppurative | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 9 |
Cataract | 4 | 4 3.0|
Anterior Chamber, Cornea, | | |
Inflammation, Suppurative | | 1 4.0|
Bilateral, Cornea, Edema | | 1 2.0|
Cornea, Edema | | 1 1.0|
Sclera, Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 6| 7| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| | L |
| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 54 |
Cyst | | 2 |
Nephropathy | 4 3 4 4 | 47 2.5|
Bilateral, Nephropathy | | 1 4.0|
Cortex, Cyst | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 54 |
Calculus Micro Observation Only | | 2 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|
| 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 3 1|
Clear Cell Focus | |
Degeneration, Cystic | 2 1 3 1 3 |
Developmental Malformation | |
Eosinophilic Focus | 1 2 X |
Fatty Change | 2 1 2 2 3 |
Hepatodiaphragmatic Nodule | X|
Thrombosis | X |
Bile Duct, Hyperplasia | 2 3 2 3 2 2 3 4 3 |
Hepatocyte, Hyperplasia | 2 2 2 3 2 2 2 2 1 4 2 2 |
Hepatocyte, Necrosis | 2 3 1 1 1 3 2 1 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Acinus, Atrophy | |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Atrium, Thrombosis | X X X |
Epicardium, Degeneration | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|
| 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Degeneration, Fatty | |
__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 4 1 2 4 3 1 1 1 4 3 2 2 2 2 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 1 |
Hyperplasia | 1 |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 4 |
Pars Distalis, Necrosis | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Inflammation, Suppurative | 4 |
Bilateral, Ectasia | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 |
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 2 4 |
Bilateral, Atrophy | |
Interstitial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 |
Hyperplasia | 4 2 4 2 2 3 3 2 4 2 3 3 2 2 2 3 3 3 3 2|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|
| 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Pigmentation | 1 1 1 |
Iliac, Congestion | |
Iliac, Hyperplasia, Lymphoid | |
Pancreatic, Congestion | |
Renal, Congestion | |
Renal, Hyperplasia, Lymphoid | |
Renal, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 2 |
Hyperplasia, Lymphoid | 2 |
Pigmentation | 1 1 1 1 1 1 1 1 2 1 2 1 1 1 2 1 1 1 2 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + M + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 |
Pigmentation | 1 1 1 1 1 1 1 2 2 2 2 1 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Infarct | 4 4 |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + |
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|
| 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Cerebellum, Compression | X |
Cerebellum, Hemorrhage | 1 3 |
Cerebrum, Compression | X X |
Cerebrum, Hemorrhage | 1 |
Ventricle, Dilatation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 2 1 1 1 1 2 1 2 2 2 1 2 1 1 2 2 2 1 2 1 2 1 2 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Alveolar Epithelium, Metaplasia, | |
Squamous | 1 |
Alveolus, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 1 |
Cornea, Inflammation, Suppurative | 2 |
Lids, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | 2 |
Nephropathy | 2 2 1 4 2 3 2 2 2 1 1 3 2 2 4 4 2 4 2 4 3 3 3|
Pigmentation | 1 |
Bilateral, Cortex, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|
| 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 3 2 2 3 3 1|
Clear Cell Focus | 1 |
Degeneration, Cystic | 3 1 2 1 2 2 2 4 2 1 3 1 1 4 |
Developmental Malformation | X |
Eosinophilic Focus | 1 |
Fatty Change | 1 2 2 3 1 2 1 1 1 |
Hepatodiaphragmatic Nodule | |
Thrombosis | |
Bile Duct, Hyperplasia | 2 4 2 2 3 2 2 2 2 3 |
Hepatocyte, Hyperplasia | 3 |
Hepatocyte, Necrosis | 1 2 1 2 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Acinus, Atrophy | 1 |
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Inflammation, Chronic | 3 |
Ulcer | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Atrium, Thrombosis | X X X |
Epicardium, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|
| 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Degeneration, Fatty | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 1 2 1 1 2 2 4 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Angiectasis | |
Hyperplasia | |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hyperplasia | 3 2|
Pars Distalis, Necrosis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 1|
Inflammation, Suppurative | |
Bilateral, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 |
Bilateral, Atrophy | 3 |
Interstitial Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 1 |
Hyperplasia | 3 2 3 3 2 2 4 1 3 2 4 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|
| 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Pigmentation | 1 |
Iliac, Congestion | 1 |
Iliac, Hyperplasia, Lymphoid | 1 |
Pancreatic, Congestion | 1 |
Renal, Congestion | 1 |
Renal, Hyperplasia, Lymphoid | 2 1 |
Renal, Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + M + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Edema | |
Hyperplasia, Lymphoid | 2 2 2 1 1 2|
Pigmentation | 1 1 2 1 1 1 2 1 1 2 2 1 2 2 1 2 2 2 2 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Edema | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia | 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hyperplasia, Lymphoid | 3 1 2 2 2 2|
Hyperplasia, Plasma Cell | 2 |
Pigmentation | 2 2 1 1 1 2 2 2 2 2 2 1 2 1 2 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 2 2 |
Infarct | 4 4 2 4 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | 2 |
__________________________________________________________________________|
Skin | + + |
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Femur, Hyperostosis | 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|
| 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.62MGM3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Cerebellum, Compression | |
Cerebellum, Hemorrhage | |
Cerebrum, Compression | X X X |
Cerebrum, Hemorrhage | |
Ventricle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Chronic | 1 1 1 2 2 2 2 1 2 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Alveolar Epithelium, Metaplasia, | |
Squamous | |
Alveolus, Pigmentation | 1 1 1 1 1 1 1 1 2 1 2 1 2 2 1 2 1 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 2 |
Cornea, Inflammation, Suppurative | |
Lids, Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Infarct | |
Nephropathy | 1 3 3 2 4 3 3 3 2 3 2 3 4 2 4 2 4 1 2 4 2 3 4 3|
Pigmentation | |
Bilateral, Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 7| 3| | |
| 2| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.62MGM3 | 9| 9| 9| | L |
| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Basophilic Focus | 2 1 | 15 1.7|
Clear Cell Focus | | 1 1.0|
Degeneration, Cystic | 1 | 20 2.0|
Developmental Malformation | | 1 |
Eosinophilic Focus | | 4 1.3|
Fatty Change | 2 | 15 1.7|
Hepatodiaphragmatic Nodule | | 1 |
Thrombosis | | 1 |
Bile Duct, Hyperplasia | 2 | 20 2.5|
Hepatocyte, Hyperplasia | 2 | 14 2.2|
Hepatocyte, Necrosis | | 14 1.7|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Atrophy | | 1 3.0|
Acinus, Atrophy | | 1 1.0|
Acinus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Ulcer | | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Erosion | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 7| 3| | |
| 2| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.62MGM3 | 9| 9| 9| | L |
| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Fibrosis | | 1 1.0|
Atrium, Thrombosis | | 6 |
Epicardium, Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | | 2 2.0|
Degeneration, Fatty | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 52 |
Cyst | | 1 |
Hyperplasia | 3 3 | 27 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Angiectasis | | 3 2.0|
Hyperplasia | | 1 1.0|
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Hyperplasia | | 3 3.0|
Pars Distalis, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + | 53 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 53 |
Ectasia | | 3 1.7|
Inflammation, Suppurative | | 1 4.0|
Bilateral, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + | 53 |
Inflammation, Chronic | | 3 1.3|
Inflammation, Chronic Active | | 1 1.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 7| 3| | |
| 2| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.62MGM3 | 9| 9| 9| | L |
| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 53 |
__________________________________________________________________________|____________|
Testes | + + + | 53 |
Atrophy | 3 | 7 3.4|
Bilateral, Atrophy | | 1 3.0|
Interstitial Cell, Hyperplasia | | 3 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Fibrosis | | 4 1.8|
Hyperplasia | 4 | 35 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + | 19 |
Pigmentation | | 4 1.0|
Iliac, Congestion | 2 | 2 1.5|
Iliac, Hyperplasia, Lymphoid | | 1 1.0|
Pancreatic, Congestion | | 1 1.0|
Renal, Congestion | 2 | 2 1.5|
Renal, Hyperplasia, Lymphoid | | 2 1.5|
Renal, Pigmentation | | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 51 |
Congestion | | 1 1.0|
Edema | | 1 2.0|
Hyperplasia, Lymphoid | | 7 1.7|
Pigmentation | 2 2 1 | 45 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
Hyperplasia, Lymphoid | | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Congestion | | 2 1.5|
Edema | | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 52 |
Congestion | | 2 2.0|
Hyperplasia, Lymphoid | 2 | 8 2.0|
Hyperplasia, Plasma Cell | | 2 2.5|
Pigmentation | 2 | 33 1.6|
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Fibrosis | 2 | 7 2.1|
Infarct | | 6 3.7|
Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 7| 3| | |
| 2| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.62MGM3 | 9| 9| 9| | L |
| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + | 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 4 |
Cyst Epithelial Inclusion | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
Hyperostosis | | 1 2.0|
Femur, Hyperostosis | | 2 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Cerebellum, Compression | | 1 |
Cerebellum, Hemorrhage | | 2 2.0|
Cerebrum, Compression | | 5 |
Cerebrum, Hemorrhage | | 1 1.0|
Ventricle, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 52 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Hemorrhage | | 1 1.0|
Inflammation, Chronic | 2 2 2 | 53 1.6|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.0|
Alveolar Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
Alveolus, Pigmentation | 1 2 2 | 53 1.3|
__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation, Chronic Active | | 2 1.5|
Inflammation, Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Cataract | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 7| 6| 7| | |
DAY ON TEST | 1| 7| 3| | |
| 2| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.62MGM3 | 9| 9| 9| | L |
| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cornea, Inflammation, Suppurative | | 1 2.0|
Lids, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Cyst | | 1 |
Infarct | | 1 2.0|
Nephropathy | 3 3 4 | 50 2.7|
Pigmentation | | 1 1.0|
Bilateral, Cortex, Cyst | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|
| 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Necrosis | 4 |
Parasite Metazoan | |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 1 1 1 1 1 2 1 1 1 2 |
Congestion | 3 |
Degeneration, Cystic | 1 1 2 2 1 3 3 3 2 2 2 1 2 1 |
Eosinophilic Focus | 1 1 1 X |
Fatty Change | 1 2 2 2 2 2 2 2 2 2 1 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | |
Pigmentation, Bile | 2 |
Thrombosis | X |
Bile Duct, Hyperplasia | 2 2 2 3 2 2 3 3 2 2 |
Hepatocyte, Hyperplasia | 1 2 3 2 2 |
Hepatocyte, Necrosis | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 3 2 |
Inflammation, Acute | |
Inflammation, Chronic | 3 2 |
Inflammation, Chronic Active | |
Ulcer | 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Suppurative | |
Pigmentation | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|
| 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 2 4 3 4 1 1 2 4 1 4 1 3 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Hyperplasia | 2 3 |
Pars Distalis, Pigmentation | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 |
Infiltration Cellular, Lymphocyte | |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 |
Ectasia | 2 |
Inflammation, Suppurative | 4 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 |
Hemorrhage | |
Bilateral, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|
| 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 2 1 1 |
Hyperplasia | 1 4 4 4 2 2 2 4 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Iliac, Ectasia | |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Pigmentation | 1 |
Renal, Congestion | 2 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 2 |
Pigmentation | 2 2 2 2 2 2 1 2 1 2 1 1 2 2 2 2 1 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | 2 2 2 2 2 3|
Pigmentation | 2 2 2 2 2 2 2 1 1 2 2 2 2 1 2 2 1 2 2 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Developmental Malformation | X |
Fibrosis | 1 2 2 2 2 2 2 2 2 |
Infarct | 3 |
Necrosis | |
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Thymus | M + + + M + + + + + + + + + + + M M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + +|
Alopecia | 2 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | |
Necrosis | 3 |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|
| 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Cerebellum, Compression | |
Cerebellum, Hemorrhage | |
Cerebellum, Ventricle, Dilatation | |
Cerebrum, Compression | X |
Cerebrum, Hemorrhage | |
Cerebrum, Ventricle, Dilatation | 1 |
Hypothalamus, Compression | |
Ventricle, Dilatation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Chronic | 2 2 2 2 2 3 2 2 2 2 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2|
Alveolar Epithelium, Hyperplasia, | |
Atypical | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Pigmentation | 2 2 2 2 2 2 1 2 2 2 2 2 2 3 2 2 2 1 1 1 2 1 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Necrosis | |
Nephropathy | 3 4 2 4 2 2 1 3 3 3 2 4 4 3 2 2 2 3 2 2 3 4 1|
Medulla, Cyst | |
Pelvis, Degeneration | |
Pelvis, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X |
Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|
DAY ON TEST | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|
| 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Suppurative | |
Necrosis | |
Parasite Metazoan | X |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 4 2 1 1 3 2 2 1 2 1 1 |
Congestion | |
Degeneration, Cystic | 1 1 2 1 1 1 1 1 1 1 1 1 |
Eosinophilic Focus | X |
Fatty Change | 2 2 2 2 3 2 1 3|
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic Active | 1 |
Pigmentation, Bile | |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 2 2 2 3 2 |
Hepatocyte, Hyperplasia | 2 2 2 2|
Hepatocyte, Necrosis | 2 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Suppurative | 3 |
Pigmentation | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|
DAY ON TEST | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|
| 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 1 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 4 4 1 4 2 2 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + M + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 4 2 |
Pars Distalis, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Infiltration Cellular, Lymphocyte | 1 |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | 4 |
Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 3 3 |
Hemorrhage | 2 |
Bilateral, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|
DAY ON TEST | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|
| 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 2 3 2 2 4 3 3 1|
__________________________________________________________________________|
Lymph Node | + + + + + +|
Iliac, Ectasia | 4 |
Iliac, Hyperplasia, Lymphoid | 3 |
Iliac, Pigmentation | |
Renal, Congestion | |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 2 2 3 2 1 |
Pigmentation | 2 2 1 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + M + + + + +|
Ectasia | 4 |
Hyperplasia, Lymphoid | 2 2 2 2 2 |
Pigmentation | 2 1 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Developmental Malformation | |
Fibrosis | 3 2 1 2 1 2 |
Infarct | 2 2|
Necrosis | 2 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + |
Alopecia | |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 2 |
Necrosis | |
Epidermis, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|
DAY ON TEST | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|
| 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25MGM3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Cerebellum, Compression | X |
Cerebellum, Hemorrhage | 1 2 1 |
Cerebellum, Ventricle, Dilatation | 2 |
Cerebrum, Compression | X X X X X |
Cerebrum, Hemorrhage | 2 |
Cerebrum, Ventricle, Dilatation | 2 |
Hypothalamus, Compression | X |
Ventricle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 3 2 2 2 3 2 2 2 3 3 2|
Alveolar Epithelium, Hyperplasia, | |
Atypical | 2 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Pigmentation | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Necrosis | 1 |
Nephropathy | 4 3 4 3 2 3 3 1 2 4 1 4 3 2 2 3 1 3 3 3 1 1 2 1|
Medulla, Cyst | X |
Pelvis, Degeneration | |
Pelvis, Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 5| 4| 6| | |
DAY ON TEST | 1| 5| 8| | |
| 9| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 2| 2| 2| | L |
| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 52 |
Inflammation, Suppurative | | 1 4.0|
Necrosis | | 1 4.0|
Parasite Metazoan | | 1 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 22 1.5|
Congestion | | 1 3.0|
Degeneration, Cystic | 2 | 27 1.5|
Eosinophilic Focus | | 5 1.0|
Fatty Change | 3 | 20 2.0|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation, Chronic Active | | 1 1.0|
Pigmentation, Bile | | 1 2.0|
Thrombosis | | 1 |
Bile Duct, Hyperplasia | 2 | 18 2.2|
Hepatocyte, Hyperplasia | | 9 2.0|
Hepatocyte, Necrosis | 1 | 4 1.3|
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Fibrosis | | 1 1.0|
Acinus, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Hyperkeratosis | | 6 2.2|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 3 2.3|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Erosion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 5| 4| 6| | |
DAY ON TEST | 1| 5| 8| | |
| 9| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 2| 2| 2| | L |
| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 3.0|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Inflammation, Chronic | | 1 1.0|
Atrium, Thrombosis | | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Degeneration, Fatty | | 6 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Hyperplasia | | 26 2.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + | 49 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Pars Distalis, Hyperplasia | | 6 2.7|
Pars Distalis, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | M + + | 52 |
Hyperplasia, Cystic | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
C-Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + | 53 |
Spermatocele | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 53 |
Ectasia | | 4 3.0|
__________________________________________________________________________|____________|
Prostate | + + + | 53 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 5| 4| 6| | |
DAY ON TEST | 1| 5| 8| | |
| 9| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 2| 2| 2| | L |
| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 4 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 53 |
Atrophy | | 3 3.3|
Ectasia | | 1 2.0|
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Testes | + + + | 53 |
Atrophy | | 7 3.3|
Hemorrhage | | 1 2.0|
Bilateral, Atrophy | | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Fibrosis | | 5 1.4|
Hyperplasia | 3 | 19 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + | 16 |
Iliac, Ectasia | | 1 4.0|
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Iliac, Pigmentation | | 1 1.0|
Renal, Congestion | | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 53 |
Hyperplasia, Lymphoid | | 10 1.8|
Pigmentation | 1 1 1 | 51 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 50 |
Hyperplasia, Lymphoid | | 6 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 52 |
Ectasia | | 1 4.0|
Hyperplasia, Lymphoid | | 11 2.1|
Pigmentation | 1 1 1 | 43 1.7|
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Congestion | | 1 3.0|
Developmental Malformation | | 1 |
Fibrosis | | 15 1.9|
Infarct | | 3 2.3|
Necrosis | | 1 2.0|
Capsule, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + | 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 5| 4| 6| | |
DAY ON TEST | 1| 5| 8| | |
| 9| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 2| 2| 2| | L |
| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
__________________________________________________________________________|____________|
Skin | | 14 |
Alopecia | | 1 2.0|
Cyst Epithelial Inclusion | | 2 |
Hyperkeratosis | | 1 2.0|
Necrosis | | 1 3.0|
Epidermis, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
Hyperostosis | | 2 1.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Cerebellum, Compression | | 1 |
Cerebellum, Hemorrhage | | 3 1.3|
Cerebellum, Ventricle, Dilatation | | 1 2.0|
Cerebrum, Compression | X | 7 |
Cerebrum, Hemorrhage | | 1 2.0|
Cerebrum, Ventricle, Dilatation | | 2 1.5|
Hypothalamus, Compression | | 1 |
Ventricle, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Hemorrhage | | 1 1.0|
Inflammation, Chronic | 2 2 3 | 53 2.1|
Alveolar Epithelium, Hyperplasia, | | |
Atypical | | 4 1.8|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolus, Pigmentation | 2 1 2 | 53 1.8|
__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation, Chronic Active | | 2 1.0|
Inflammation, Suppurative | | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 5| 4| 6| | |
DAY ON TEST | 1| 5| 8| | |
| 9| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
1.25MGM3 | 2| 2| 2| | L |
| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Cyst | | 2 |
Necrosis | | 1 1.0|
Nephropathy | 4 | 48 2.6|
Medulla, Cyst | | 1 |
Pelvis, Degeneration | 4 | 1 4.0|
Pelvis, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Calculus Micro Observation Only | | 3 |
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|
| 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 2 2 1 1 1 1 1 1 2|
Congestion | 2|
Degeneration, Cystic | 1 2 1 2 1 1 1 1 2 1 2 2 1|
Developmental Malformation | X |
Eosinophilic Focus | X 1 1 |
Fatty Change | 2 2 2 2 1|
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X |
Infarct | |
Mixed Cell Focus | |
Thrombosis | |
Bile Duct, Hyperplasia | 2 3 2 2 2 2 2 2 3 2 2 |
Hepatocyte, Hyperplasia | 4 2 2 2 2 1 |
Hepatocyte, Necrosis | 1 1 3 1 |
Portal Vein, Thrombosis | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Inflammation, Chronic | 2 |
Atrium, Congestion | |
Atrium, Thrombosis | X X |
Ventricle, Fibrosis | |
Ventricle, Inflammation, Chronic | |
Ventricle, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|
| 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 2 4 3 4 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 1 1 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 4 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Glandular | |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 4 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 2 3 3 2 2 2 3 3 3 3 3 2 2 3 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Hyperplasia, Macrophage | |
Iliac, Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|
| 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Edema | |
Renal, Pigmentation | 1 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Edema | |
Hyperplasia, Lymphoid | 2 2 2 1 2 2 2 1 1 2 1|
Pigmentation | 2 2 2 2 2 2 2 1 2 2 2 2 1 2 2 2 2 1 2 2 2 1 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 2 3 1 2 3 2 2 3 2 1|
Hyperplasia, Plasma Cell | 3 |
Pigmentation | 2 1 2 2 2 1 1 1 2 2 2 2 1 2 2 2 1 1 2 2 2 1 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 2 2 1 |
Infarct | 2 4 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Skin | + + |
Cyst Epithelial Inclusion | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 1 |
Femur, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Cerebellum, Compression | X |
Cerebrum, Compression | X X X X|
Cerebrum, Necrosis | |
Cerebrum, Ventricle, Dilatation | 2 2|
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|
DAY ON TEST | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|
| 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X |
Hemorrhage | 2 |
Inflammation, Chronic | 3 3 3 3 2 2 2 2 3 2 2 3 2 3 3 3 2 3 3 3 3 3 2 2|
Alveolar Epithelium, Hyperplasia, | |
Atypical | 3 |
Alveolus, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | |
Infarct | 3 |
Nephropathy | 4 2 2 3 2 3 2 3 2 3 1 3 1 2 3 2 3 2 3 1 3|
Cortex, Cyst | X |
Medulla, Congestion | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|
| 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 1 3 3 1 2 1 2 |
Congestion | 2 2 |
Degeneration, Cystic | 2 3 1 2 1 2 1 2 1 4 1 1 2 1 1 |
Developmental Malformation | |
Eosinophilic Focus | 1 X 1 |
Fatty Change | 1 1 2 2 1 2|
Hemorrhage | 1 |
Hepatodiaphragmatic Nodule | X |
Infarct | 4 |
Mixed Cell Focus | X |
Thrombosis | X |
Bile Duct, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 2 |
Hepatocyte, Hyperplasia | 2 1 1 2 |
Hepatocyte, Necrosis | 1 1 2 2 2 |
Portal Vein, Thrombosis | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Acinus, Atrophy | 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Inflammation, Chronic | |
Atrium, Congestion | 4 |
Atrium, Thrombosis | X X |
Ventricle, Fibrosis | 2 |
Ventricle, Inflammation, Chronic | 2 |
Ventricle, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|
| 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Ventricle, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 3 4 2 1 2 4 2 3 2 1 1 4|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 4 1 3 2 2 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia, Glandular | 4 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 2 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 2 |
Hyperplasia | 2 3 2 3 3 3 2 3 3 2 3 2 2 3 4 3 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Hyperplasia, Macrophage | 4 |
Iliac, Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|
| 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Edema | 2 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Edema | 2 |
Hyperplasia, Lymphoid | 1 3 1 2 1 1 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1 1 2 2 2 1 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Hyperplasia, Lymphoid | 2 2 1 1 2 2 2 |
Hyperplasia, Plasma Cell | |
Pigmentation | 1 2 2 2 1 1 2 2 1 3 2 2 2 1 2 2 1 2 1 2 2 2 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 2 2 |
Infarct | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + M + + + + + + + +|
Congestion | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Skin | + + + + |
Cyst Epithelial Inclusion | X |
Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Femur, Hyperostosis | 1 2 2 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Cerebellum, Compression | |
Cerebrum, Compression | X |
Cerebrum, Necrosis | 1 |
Cerebrum, Ventricle, Dilatation | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|
| 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Hemorrhage | 3 |
Inflammation, Chronic | 2 3 2 2 3 3 2 3 3 3 3 2 3 3 3 2 2 3 3 2 3 2 3 2 2|
Alveolar Epithelium, Hyperplasia, | |
Atypical | 2 1 |
Alveolus, Pigmentation | 2 3 1 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3 3 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Fibrosis | 2 |
Infarct | 2 |
Nephropathy | 4 3 3 4 3 4 4 4 2 2 2 3 1 4 2 1 2 2 3 2 |
Cortex, Cyst | |
Medulla, Congestion | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 4| 6| 7| | |
DAY ON TEST | 7| 4| 1| | |
| 5| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 5| | L |
| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 52 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 52 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + | 52 |
Basophilic Focus | 1 | 20 1.7|
Congestion | 4 | 4 2.5|
Degeneration, Cystic | | 28 1.5|
Developmental Malformation | | 1 |
Eosinophilic Focus | X | 7 1.0|
Fatty Change | | 11 1.6|
Hemorrhage | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 4 |
Infarct | | 1 4.0|
Mixed Cell Focus | | 1 |
Thrombosis | | 1 |
Bile Duct, Hyperplasia | 2 | 25 2.1|
Hepatocyte, Hyperplasia | | 10 1.9|
Hepatocyte, Necrosis | 3 | 10 1.7|
Portal Vein, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
Congestion | | 1 1.0|
Acinus, Atrophy | | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 52 |
Hyperkeratosis | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 52 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 52 |
Infarct | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 4| 6| 7| | |
DAY ON TEST | 7| 4| 1| | |
| 5| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 5| | L |
| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Atrium, Congestion | | 1 4.0|
Atrium, Thrombosis | | 4 |
Ventricle, Fibrosis | | 1 2.0|
Ventricle, Inflammation, Chronic | | 1 2.0|
Ventricle, Mineralization | | 1 1.0|
Ventricle, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 52 |
Degeneration, Fatty | | 3 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 52 |
Hyperplasia | | 24 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 52 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + | 49 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Pars Distalis, Angiectasis | | 3 1.7|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 1 | 11 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
C-Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + | 52 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 51 |
Ectasia | | 1 3.0|
Hyperplasia, Glandular | | 1 4.0|
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Prostate | + + + | 52 |
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 4| 6| 7| | |
DAY ON TEST | 7| 4| 1| | |
| 5| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 5| | L |
| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + | 52 |
Atrophy | | 10 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 52 |
Fibrosis | | 4 2.0|
Hyperplasia | 3 2 | 35 2.6|
__________________________________________________________________________|____________|
Lymph Node | | 15 |
Hyperplasia, Macrophage | | 1 4.0|
Iliac, Pigmentation | | 1 1.0|
Renal, Edema | | 1 2.0|
Renal, Pigmentation | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 52 |
Congestion | 2 | 3 2.3|
Edema | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 18 1.6|
Pigmentation | 2 1 2 | 51 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
Hyperplasia, Lymphoid | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 51 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 52 |
Congestion | 2 | 3 1.7|
Hyperplasia, Lymphoid | | 18 1.9|
Hyperplasia, Plasma Cell | | 1 3.0|
Pigmentation | 1 2 2 | 50 1.7|
__________________________________________________________________________|____________|
Spleen | + + + | 52 |
Fibrosis | 2 | 10 1.7|
Infarct | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + M + | 48 |
Congestion | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 52 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 6 |
Cyst Epithelial Inclusion | | 1 |
Pigmentation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 4| 6| 7| | |
DAY ON TEST | 7| 4| 1| | |
| 5| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 5| | L |
| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 52 |
Hyperostosis | | 2 1.0|
Femur, Hyperostosis | | 4 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 52 |
Hemorrhage | | 1 1.0|
Cerebellum, Compression | | 1 |
Cerebrum, Compression | | 5 |
Cerebrum, Necrosis | | 1 1.0|
Cerebrum, Ventricle, Dilatation | | 3 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 51 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 2 1.0|
__________________________________________________________________________|____________|
Lung | + + + | 52 |
Congestion | 3 | 1 3.0|
Cyst | | 1 |
Hemorrhage | | 2 2.5|
Inflammation, Chronic | 3 3 3 | 53 2.6|
Alveolar Epithelium, Hyperplasia, | | |
Atypical | | 3 2.0|
Alveolus, Pigmentation | 2 2 2 | 52 2.1|
__________________________________________________________________________|____________|
Nose | + + + | 52 |
Inflammation, Chronic Active | 1 | 5 1.2|
Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Cataract | | 3 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 52 |
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05123-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL OXIDE Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:44:36
__________________________________________________________________________________________________________________________________
| 4| 6| 7| | |
DAY ON TEST | 7| 4| 1| | |
| 5| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2.5MG/M3 | 5| 5| 5| | L |
| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Fibrosis | | 1 2.0|
Infarct | | 2 2.5|
Nephropathy | 2 3 | 43 2.6|
Cortex, Cyst | | 1 |
Medulla, Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
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