TDMS Study 05123-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: LITRI NICKEL OXIDE DATE: 05/20/95
EXPERIMENT: 05123 TEST: 05 TIME: 04:51:15
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: Y01-ES-30108 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C00862
PATHOLOGIST: P. HALEY CAS: 001313991
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: LITRI NICKEL OXIDE DATE: 05/20/95
EXPERIMENT: 05123 TEST: 05 TIME: 04:51:15
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: Y01-ES-30108 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C00862
PATHOLOGIST: P. HALEY CAS: 001313991
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/M3 |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 40 CENSORED DEATHS 5 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 187 475 503 509 524 566 566 569 573 573 |
| 581 584 585 594 598 622 622 622 622 624 |
| 624 628 628 629 656 661 669 678 682 692 |
| 696 697 699 699 705 705 713 713 715 724 |
| CENSORED DEATHS |
| 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 MG/M3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 6 UNCENSORED DEATHS 0 CENSORED DEATHS 6 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 199 199 199 199 199 199 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.62MGM3 |
| --------------------- |
| |
| TOTAL 58 UNCENSORED DEATHS 38 CENSORED DEATHS 5 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 466 503 519 520 524 538 542 564 567 570 |
| 570 572 595 618 618 623 629 633 643 647 |
| 649 670 675 679 679 685 686 696 697 697 |
| 700 703 704 709 712 717 717 720 |
| CENSORED DEATHS |
| 459 459 459 459 459 |
| |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.62MGM3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 7 UNCENSORED DEATHS 0 CENSORED DEATHS 7 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 199 199 199 199 199 199 199 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.25MGM3 |
| --------------------- |
| |
| TOTAL 58 UNCENSORED DEATHS 38 CENSORED DEATHS 5 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 202 367 457 519 525 541 546 564 567 567 |
| 570 578 588 592 606 618 618 619 619 620 |
| 624 627 647 647 650 674 676 681 681 690 |
| 690 697 706 706 706 707 717 730 |
| CENSORED DEATHS |
| 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.25MGM3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 7 UNCENSORED DEATHS 0 CENSORED DEATHS 7 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 199 199 199 199 199 199 199 |
| |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2.5MG/M3 |
| --------------------- |
| |
| TOTAL 57 UNCENSORED DEATHS 40 CENSORED DEATHS 5 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 467 468 475 536 539 544 545 553 565 570 |
| 570 570 578 583 594 595 615 615 623 624 |
| 625 625 633 647 651 660 660 665 665 671 |
| 671 676 679 697 707 707 709 717 719 723 |
| CENSORED DEATHS |
| 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5MG/M3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 7 UNCENSORED DEATHS 0 CENSORED DEATHS 7 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 199 199 199 199 199 199 199 |
| |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/M3 | 100.0 100.0 98.3 98.3 98.3 96.5 90.9 72.3 51.9 26.0 |
| | |
| | |
|0 | 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|MG/M3 LUNGT| |
| | |
|0.62MGM3 | 100.0 100.0 100.0 100.0 100.0 98.1 86.8 75.5 60.4 28.3 |
| | |
| | |
|0.62MGM3 | 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|LUNGTX | |
| | |
|1.25MGM3 | 100.0 100.0 98.3 98.3 96.6 94.8 89.1 74.0 53.1 28.4 |
| | |
| | |
|1.25MGM3 | 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|LUNGTX | |
| | |
|2.5MG/M3 | 100.0 100.0 100.0 100.0 100.0 94.2 86.5 69.2 44.2 23.1 |
| | |
| | |
|2.5MG/M3 | 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|LUNGTX | |
| | |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/M3 0 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3 |
| MG/M3 LUNGTX LUNGTX LUNGTX LUNGTX |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 26.0% 0.0% 28.3% 0.0% 28.4% 0.0% 23.1% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.563 ----- P=0.773N P=1.000N P=1.000N P=1.000N P=0.719 P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 617.8 . 630.4 . 608.9 . 618.4 . |
|NATURAL DEATHS (C) | (15.1) ( . ) (11.8) ( . ) (16.6) ( . ) (11.1) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 631.7 199.0 642.2 199.0 628.1 199.0 628.5 199.0 |
|(STANDARD ERROR) | (13.8) ( 0.0) (12.2) ( 0.0) (14.7) ( 0.0) (12.1) ( 0.0) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/M3 |
| --------------------- |
| |
| TOTAL 58 UNCENSORED DEATHS 32 CENSORED DEATHS 5 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 348 354 403 468 468 553 558 563 564 586 |
| 594 607 618 622 624 636 640 643 644 655 |
| 664 678 689 692 699 713 713 714 714 715 |
| 727 727 |
| CENSORED DEATHS |
| 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 MG/M3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 7 UNCENSORED DEATHS 0 CENSORED DEATHS 7 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 200 200 200 200 200 200 200 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.62MGM3 |
| --------------------- |
| |
| TOTAL 58 UNCENSORED DEATHS 27 CENSORED DEATHS 5 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 423 472 475 509 524 536 536 537 600 614 |
| 622 629 634 640 652 660 667 668 674 678 |
| 703 707 719 721 722 725 725 |
| CENSORED DEATHS |
| 460 460 460 460 460 |
| |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.62MGM3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 7 UNCENSORED DEATHS 0 CENSORED DEATHS 7 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 200 200 200 200 200 200 200 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.25MGM3 |
| --------------------- |
| |
| TOTAL 58 UNCENSORED DEATHS 33 CENSORED DEATHS 5 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 346 436 466 471 476 494 503 514 536 565 |
| 594 611 614 618 627 634 638 640 643 643 |
| 647 655 686 689 690 690 690 713 713 722 |
| 727 727 727 |
| CENSORED DEATHS |
| 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.25MGM3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 7 UNCENSORED DEATHS 0 CENSORED DEATHS 7 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 200 200 200 200 200 200 200 |
| |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2.5MG/M3 |
| --------------------- |
| |
| TOTAL 58 UNCENSORED DEATHS 27 CENSORED DEATHS 5 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 466 467 494 496 519 538 539 550 559 570 |
| 570 577 600 607 609 618 633 636 655 663 |
| 664 671 704 706 718 719 725 |
| CENSORED DEATHS |
| 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5MG/M3 LUNGTX |
| ---------------------------- |
| |
| TOTAL 7 UNCENSORED DEATHS 1 CENSORED DEATHS 6 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 90 |
| CENSORED DEATHS |
| 200 200 200 200 200 200 |
| |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/M3 | 100.0 100.0 100.0 96.6 94.8 91.0 91.0 79.7 60.7 39.8 |
| | |
| | |
|0 | 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|MG/M3 LUNGT| |
| | |
|0.62MGM3 | 100.0 100.0 100.0 100.0 98.3 94.5 85.0 83.2 69.9 49.1 |
| | |
| | |
|0.62MGM3 | 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|LUNGTX | |
| | |
|1.25MGM3 | 100.0 100.0 100.0 98.3 98.3 90.9 83.3 79.5 58.7 37.9 |
| | |
| | |
|1.25MGM3 | 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|LUNGTX | |
| | |
|2.5MG/M3 | 100.0 100.0 100.0 100.0 100.0 96.2 86.8 75.5 60.4 49.1 |
| | |
| | |
|2.5MG/M3 | 85.7 85.7 85.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|LUNGTX | |
| | |
==================================================================================
NICKEL OXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/M3 0 0.62MGM3 0.62MGM3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3 |
| MG/M3 LUNGTX LUNGTX LUNGTX LUNGTX |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 39.8% 0.0% 49.1% 0.0% 37.9% 0.0% 49.1% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.834N ----- P=0.392N ----- P=0.921 ----- P=0.563N P=0.206 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 612.3 . 621.2 . 610.5 . 602.7 90.0 |
|NATURAL DEATHS (C) | (18.6) ( . ) (17.1) ( . ) (17.2) ( . ) (15.2) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 641.4 200.0 655.6 200.0 638.4 200.0 647.0 184.3 |
|(STANDARD ERROR) | (14.5) ( 0.0) (13.1) ( 0.0) (14.2) ( 0.0) (13.1) (15.7) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NICKEL OXIDE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/M3 = 1
0 MG/M3 LUNGTX = 2
0.62MGM3 = 3
0.62MGM3 LUNGTX = 4
1.25MGM3 = 5
1.25MGM3 LUNGTX = 6
2.5MG/M3 = 7
2.5MG/M3 LUNGTX = 8
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 5 31 3
| 5 571 11 1 7
P | 1 33 1
E | 37 11
R 80 + 5111
C | 371 115 3
E | 7157133
N | 711333
T 60 + 57 3 33
| 17 51 1 33
S | 7 1111 3
U | 77 111
R 40 + 77 5333
V | 7 1113
I | 5111 3
V | 71 1
A 20 +
L |
|
|
0 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 105 obs hidden.
NICKEL OXIDE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/M3 = 1
0 MG/M3 LUNGTX = 2
0.62MGM3 = 3
0.62MGM3 LUNGTX = 4
1.25MGM3 = 5
1.25MGM3 LUNGTX = 6
2.5MG/M3 = 7
2.5MG/M3 LUNGTX = 8
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 8 11 3 5 73
| 1 1 5 13 7 3 3
P | 15 55 3 3 11
E | 8 8 5 5 3 7117 1 3 3
R 80 + 5771 1 1313
C | 7 7751133 3
E | 7 7111 3 33
N | 71 1 133
T 60 + 555 17151 3 3
| 5117133
S | 5 573 3
U | 111
R 40 + 1 1
V |
I |
V |
A 20 +
L |
|
|
0 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 84 obs hidden.