TDMS Study 05127-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
BARIUM CHLORIDE DIHYDRATE
NTP Experiment-Test: 05127-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
Facility: TSI Mason Research
Chemical CAS #: 10326279
Lock Date: 11/15/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 7 10 6
Early Deaths
Moribund 9 11 9 35
Dead 3 5 5 6
Survivors
Terminal Sacrifice 37 37 36 13
Dead 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (54) (55) (56) (54)
Autolysis 1 (2%)
Dilatation 2 (4%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Intestine Large, Colon (57) (58) (58) (57)
Hyperplasia, Lymphoid 1 (2%)
Intestine Large, Rectum (58) (59) (59) (60)
Ulcer 1 (2%)
Intestine Large, Cecum (58) (58) (57) (55)
Edema 1 (2%)
Hyperplasia, Lymphoid 39 (67%) 30 (52%) 35 (61%) 23 (42%)
Intestine Small, Duodenum (57) (57) (58) (54)
Fibrosis 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Acute 1 (2%)
Intestine Small, Jejunum (57) (57) (56) (54)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Inflammation, Acute 1 (2%)
Intestine Small, Ileum (59) (55) (56) (52)
Hyperplasia, Lymphoid 2 (3%) 3 (5%)
Ulcer 1 (2%)
Liver (60) (60) (60) (60)
Amyloid Deposition 1 (2%)
Angiectasis 1 (2%) 2 (3%) 1 (2%)
Angiectasis, Focal 1 (2%)
Basophilic Focus 3 (5%) 2 (3%) 1 (2%)
Clear Cell Focus 1 (2%) 4 (7%) 2 (3%) 2 (3%)
Congestion 1 (2%) 1 (2%)
Eosinophilic Focus 4 (7%) 4 (7%) 9 (15%) 2 (3%)
Fatty Change 8 (13%) 12 (20%) 10 (17%) 7 (12%)
Granuloma 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
Hemorrhage, Focal 1 (2%) 1 (2%) 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 2 (3%)
Mineralization, Focal 1 (2%)
Mixed Cell Focus 1 (2%) 2 (3%) 1 (2%)
Necrosis, Focal 5 (8%) 6 (10%) 1 (2%) 4 (7%)
Mesentery (3) (7) (4) (4)
Fibrosis 1 (25%)
Fat, Necrosis 3 (100%) 5 (71%) 4 (100%) 4 (100%)
Pancreas (60) (59) (60) (60)
Congestion 1 (2%)
Cyst 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic, Focal 4 (7%) 1 (2%) 2 (3%) 1 (2%)
Acinus, Atrophy 2 (3%)
Duct, Ectasia 1 (2%)
Salivary Glands (60) (59) (60) (59)
Congestion 1 (2%)
Inflammation, Chronic, Focal 8 (13%) 3 (5%) 7 (12%) 4 (7%)
Stomach, Forestomach (60) (58) (59) (59)
Abscess 2 (3%) 1 (2%)
Acanthosis 2 (3%) 5 (8%)
Bulla 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Diverticulum 1 (2%) 1 (2%) 2 (3%)
Edema 1 (2%)
Hyperkeratosis 1 (2%) 2 (3%) 1 (2%)
Ulcer 2 (3%) 1 (2%) 1 (2%) 4 (7%)
Stomach, Glandular (59) (58) (58) (59)
Diverticulum 1 (2%)
Erosion 3 (5%) 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Mineralization 1 (2%) 2 (3%)
Necrosis, Focal 1 (2%)
Ulcer 1 (2%) 1 (2%)
Mucosa, Hyperplasia 1 (2%)
Tongue (1) (2) (2)
Angiectasis 2 (100%)
Hyperkeratosis 2 (100%)
Necrosis, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Cardiomyopathy 2 (3%) 2 (3%) 1 (2%)
Dilatation 1 (2%)
Edema 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Pericardium, Fibrosis 1 (2%)
Valve, Pigmentation 2 (3%)
Ventricle, Hypertrophy 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (58)
Angiectasis 1 (2%)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%) 2 (3%)
Capsule, Hyperplasia 1 (2%)
Zona Reticularis, Degeneration, Fatty 1 (2%)
Zona Reticularis, Hemorrhage 3 (5%)
Zona Reticularis, Hyperplasia 1 (2%)
Islets, Pancreatic (60) (59) (60) (60)
Hyperplasia 14 (23%) 14 (24%) 13 (22%) 9 (15%)
Parathyroid Gland (38) (44) (40) (40)
Hyperplasia 1 (3%)
Pituitary Gland (58) (57) (57) (53)
Congestion 2 (4%) 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hyperplasia, Focal 11 (19%) 7 (12%) 6 (11%) 6 (11%)
Rathke's Cleft, Hemorrhage 1 (2%)
Thyroid Gland (60) (60) (59) (59)
Atrophy 1 (2%)
Cyst 1 (2%)
Inflammation, Acute, Focal 1 (2%)
C-Cell, Hyperplasia 2 (3%)
Follicle, Cyst 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 4 (7%) 6 (10%) 2 (3%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1) (2)
Cyst 1 (50%)
Ovary (59) (59) (59) (59)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Congestion 1 (2%) 1 (2%)
Cyst 18 (31%) 10 (17%) 13 (22%) 10 (17%)
Hemorrhage 1 (2%) 3 (5%)
Thrombosis 1 (2%)
Follicle, Hemorrhage 2 (3%) 1 (2%)
Uterus (60) (60) (60) (60)
Angiectasis 3 (5%) 2 (3%) 3 (5%)
Atrophy 4 (7%) 4 (7%) 20 (33%)
Cyst 1 (2%)
Dilatation 17 (28%) 14 (23%) 15 (25%) 6 (10%)
Hemorrhage 2 (3%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Endometrium, Cyst 2 (3%)
Endometrium, Hyperplasia, Cystic 48 (80%) 43 (72%) 42 (70%) 26 (43%)
Endometrium, Metaplasia, Squamous 1 (2%)
Lumen, Hemorrhage 1 (2%)
Myometrium, Inflammation, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (43) (1) (25) (13)
Neutrophilia 1 (2%) 1 (4%)
Bone Marrow (59) (60) (59) (58)
Atrophy 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Megakaryocyte 1 (2%)
Hyperplasia, Neutrophil 3 (5%) 4 (7%) 2 (3%) 3 (5%)
Myelofibrosis 37 (63%) 35 (58%) 33 (56%) 18 (31%)
Lymph Node (6) (5) (8) (2)
Lumbar, Infiltration Cellular, Plasma Cell 2 (25%)
Lumbar, Inflammation, Acute 1 (13%)
Lumbar, Lymphatic, Angiectasis 2 (25%)
Mediastinal, Congestion 1 (17%)
Mediastinal, Hyperplasia, Lymphoid 1 (20%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (13%)
Lymph Node, Mandibular (58) (58) (59) (46)
Depletion Lymphoid 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Infiltration Cellular, Plasma Cell 1 (2%)
Lymphatic, Angiectasis 2 (3%)
Lymph Node, Mesenteric (58) (55) (59) (45)
Angiectasis 1 (2%)
Congestion 2 (4%) 1 (2%)
Depletion Lymphoid 10 (22%)
Hyperplasia, Lymphoid 2 (3%)
Necrosis, Focal 1 (2%)
Lymphatic, Angiectasis 2 (4%)
Spleen (60) (60) (58) (58)
Amyloid Deposition 2 (3%)
Congestion 3 (5%) 2 (3%) 2 (3%)
Depletion Lymphoid 2 (3%) 2 (3%) 11 (19%)
Fibrosis 1 (2%) 3 (5%)
Hematopoietic Cell Proliferation 12 (20%) 11 (18%) 13 (22%) 10 (17%)
Hyperplasia, Lymphoid 1 (2%) 2 (3%)
Infarct 1 (2%)
Necrosis, Focal 2 (3%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%) 2 (3%)
Thymus (51) (52) (56) (44)
Depletion Lymphoid 1 (2%) 1 (2%) 12 (27%)
Hyperplasia, Lymphoid 2 (4%)
Necrosis, Focal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (54) (41) (58) (47)
Ectasia 1 (2%)
Skin (60) (59) (60) (59)
Congestion 1 (2%)
Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 1 (2%)
Mineralization 27 (45%) 30 (50%) 30 (50%) 24 (40%)
Mineralization, Focal 4 (7%) 4 (7%) 3 (5%) 2 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Congestion 2 (3%) 1 (2%) 2 (3%)
Hemorrhage 1 (2%) 1 (2%) 2 (3%)
Hyperplasia, Lymphoid 1 (2%)
Alveolar Epithelium, Metaplasia 1 (2%) 3 (5%)
Peribronchial, Inflammation, Chronic 1 (2%)
Nose (59) (60) (59) (60)
Degeneration, Hyaline 1 (2%) 1 (2%) 2 (3%) 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 45 (76%) 44 (73%) 41 (69%) 36 (60%)
Inflammation, Chronic, Focal 10 (17%) 3 (5%) 9 (15%) 6 (10%)
Metaplasia, Squamous 4 (7%) 4 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Artery, Internal Ear, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Amyloid Deposition 2 (3%)
Atrophy, Focal 2 (3%) 2 (3%) 4 (7%) 1 (2%)
Casts 1 (2%) 1 (2%)
Congestion 1 (2%) 1 (2%)
Crystals 36 (60%)
Glomerulosclerosis 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Focal 1 (2%)
Metaplasia, Osseous 1 (2%)
Mineralization 3 (5%) 1 (2%) 2 (3%)
Nephropathy 2 (3%) 1 (2%) 37 (62%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Degeneration 2 (3%)
Renal Tubule, Dilatation 2 (3%) 1 (2%) 2 (3%)
Renal Tubule, Pigmentation, Hemosiderin 1 (2%)
Renal Tubule, Regeneration 6 (10%) 6 (10%) 9 (15%) 2 (3%)
Urinary Bladder (57) (53) (56) (54)
Hyperplasia, Lymphoid 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic, Focal 4 (7%) 2 (4%) 4 (7%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 59 60
Scheduled Sacrifice 9 10 10 10
Early Deaths
Moribund 5 5 6 10
Dead 1 2 4 8
Survivors
Terminal Sacrifice 44 43 38 32
Moribund 1
Dead 1
Animals Examined Microscopically 60 60 59 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (53) (57) (56) (50)
Degeneration, Hyaline 1 (2%)
Dilatation 3 (6%) 1 (2%) 1 (2%)
Intestine Large, Colon (55) (58) (57) (56)
Parasite Metazoan 1 (2%)
Intestine Large, Rectum (56) (58) (56) (57)
Parasite Metazoan 1 (2%)
Intestine Large, Cecum (57) (59) (57) (56)
Hyperplasia, Lymphoid 29 (51%) 34 (58%) 39 (68%) 9 (16%)
Serosa, Fibrosis 1 (2%)
Intestine Small, Jejunum (58) (58) (56) (54)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (58) (53) (56) (54)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Liver (60) (60) (58) (60)
Angiectasis 3 (5%)
Basophilic Focus 2 (3%) 1 (2%)
Clear Cell Focus 8 (13%) 13 (22%) 5 (9%) 2 (3%)
Clear Cell Focus, Multiple 1 (2%)
Congestion 1 (2%)
Eosinophilic Focus 9 (15%) 9 (15%) 3 (5%) 5 (8%)
Fatty Change 9 (15%) 9 (15%) 13 (22%) 11 (18%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 2 (3%)
Infarct 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis, Focal 4 (7%) 2 (3%) 3 (5%) 1 (2%)
Nuclear Alteration 1 (2%) 1 (2%)
Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Fibrosis 1 (2%)
Artery, Thrombosis 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Mesentery (3) (1) (1) (2)
Fibrosis 1 (100%)
Inflammation, Chronic 1 (33%)
Inflammation, Granulomatous 1 (100%) 1 (50%)
Fat, Necrosis 1 (33%) 1 (100%) 1 (50%)
Pancreas (59) (60) (58) (60)
Congestion 1 (2%)
Inflammation, Granulomatous 1 (2%)
Necrosis, Focal 1 (2%)
Serosa, Necrosis 1 (2%)
Pharynx (1) (1)
Developmental Malformation 1 (100%)
Salivary Glands (60) (60) (59) (60)
Inflammation, Chronic, Focal 2 (3%) 2 (3%) 3 (5%) 1 (2%)
Stomach, Forestomach (59) (60) (58) (58)
Acanthosis 1 (2%) 3 (5%) 1 (2%)
Diverticulum 1 (2%)
Hyperkeratosis 1 (2%) 3 (5%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Granulomatous 1 (2%)
Ulcer 2 (3%) 1 (2%)
Stomach, Glandular (59) (60) (57) (57)
Cyst Epithelial Inclusion 1 (2%)
Diverticulum 1 (2%)
Erosion 1 (2%)
Hyperplasia, Focal 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Granulomatous 1 (2%)
Metaplasia, Squamous 1 (2%)
Mineralization 1 (2%)
Necrosis, Focal 1 (2%)
Ulcer 1 (2%)
Tongue (2) (1)
Depletion Cellular 1 (50%)
Hemorrhage, Focal 1 (100%)
Pigmentation 1 (50%)
Tooth (1)
Hypertrophy 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (59) (60)
Cardiomyopathy 1 (2%)
Dilatation 3 (5%) 1 (2%)
Mineralization 1 (2%)
Perivascular, Inflammation, Chronic 1 (2%)
Valve, Pigmentation 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58) (60) (57) (58)
Accessory Adrenal Cortical Nodule 1 (2%)
Atrophy 1 (2%)
Congestion 1 (2%) 1 (2%)
Cyst 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%)
Hyperplasia 2 (3%) 2 (3%) 2 (4%) 3 (5%)
Hyperplasia, Focal 15 (26%) 17 (28%) 14 (25%) 5 (9%)
Hypertrophy, Focal 1 (2%) 3 (5%) 1 (2%)
Capsule, Hyperplasia 2 (4%)
Adrenal Medulla (55) (57) (54) (56)
Hemorrhage 1 (2%)
Islets, Pancreatic (59) (60) (56) (60)
Atrophy 1 (2%)
Hyperplasia 27 (46%) 29 (48%) 25 (45%) 21 (35%)
Hypoplasia 1 (2%)
Pituitary Gland (56) (57) (54) (52)
Congestion 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Cyst 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 1 (2%)
Thyroid Gland (59) (57) (58) (58)
Follicle, Cyst 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia, Focal 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (59) (59) (60)
Fibrosis, Focal 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Penis (1)
Inflammation, Acute 1 (100%)
Preputial Gland (34) (41) (30) (37)
Abscess 1 (3%)
Cyst 17 (50%) 23 (56%) 22 (73%) 20 (54%)
Cyst, Multiple 1 (3%)
Cyst, Two 3 (9%) 1 (2%) 1 (3%) 8 (22%)
Ectasia 21 (62%) 21 (51%) 12 (40%) 16 (43%)
Inflammation, Acute, Focal 1 (3%) 1 (2%)
Inflammation, Chronic 1 (3%)
Inflammation, Chronic, Focal 1 (2%)
Prostate (59) (57) (57) (59)
Cyst 1 (2%)
Dilatation 1 (2%)
Hemorrhage, Focal 1 (2%)
Inflammation, Chronic 2 (3%)
Inflammation, Chronic, Focal 1 (2%) 2 (4%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Seminal Vesicle (59) (60) (59) (60)
Atrophy 1 (2%)
Congestion 1 (2%)
Dilatation 11 (19%) 11 (18%) 10 (17%) 2 (3%)
Fibrosis 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Granulomatous 1 (2%)
Testes (60) (60) (59) (60)
Interstitial Cell, Hyperplasia 2 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (49) (1) (27) (22)
Neutrophilia 2 (9%)
Bone Marrow (59) (60) (57) (58)
Hyperplasia 1 (2%)
Hyperplasia, Neutrophil 1 (2%) 2 (4%) 4 (7%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node, Mandibular (41) (50) (51) (43)
Lymphatic, Angiectasis 1 (2%) 2 (4%)
Lymph Node, Mesenteric (58) (57) (56) (49)
Congestion 3 (5%) 1 (2%) 1 (2%) 2 (4%)
Depletion Lymphoid 1 (2%) 4 (8%)
Hyperplasia, Lymphoid 4 (7%)
Infiltration Cellular, Plasma Cell 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Necrosis, Focal 1 (2%) 2 (4%) 1 (2%)
Lymphatic, Angiectasis 1 (2%)
Spleen (59) (60) (58) (60)
Angiectasis 1 (2%)
Congestion 1 (2%) 4 (7%)
Depletion Lymphoid 8 (13%) 4 (7%) 10 (17%)
Developmental Malformation 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 7 (12%) 11 (18%) 11 (19%) 6 (10%)
Necrosis, Focal 2 (3%)
Thymus (48) (51) (51) (45)
Cyst 1 (2%)
Depletion Lymphoid 2 (4%) 5 (11%)
Necrosis, Focal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (59) (59)
Congestion 1 (2%)
Edema 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Granulomatous 1 (2%)
Pigmentation 1 (2%)
Ulcer 1 (2%)
Subcutaneous Tissue, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (58) (60)
Mineralization 25 (42%) 25 (42%) 22 (38%) 35 (58%)
Mineralization, Focal 1 (2%) 7 (12%) 7 (12%) 4 (7%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (59) (60)
Congestion 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05127-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 21:44:58
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B6C3F1 MICE MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
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RESPIRATORY SYSTEM - CONT
Inflammation, Granulomatous 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Alveolar Epithelium, Metaplasia 2 (3%) 3 (5%) 2 (3%) 4 (7%)
Nose (60) (60) (58) (60)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic 42 (70%) 43 (72%) 31 (53%) 42 (70%)
Inflammation, Chronic, Focal 6 (10%) 4 (7%) 10 (17%) 9 (15%)
Metaplasia, Squamous 1 (2%) 1 (2%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (59) (60) (58) (60)
Atrophy, Focal 4 (7%) 4 (7%)
Autolysis 1 (2%)
Casts 1 (2%)
Congestion 1 (2%)
Crystals 1 (2%) 22 (37%)
Cyst 4 (7%) 1 (2%) 4 (7%) 2 (3%)
Glomerulosclerosis 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 2 (3%)
Mineralization 28 (47%) 33 (55%) 32 (55%) 36 (60%)
Mineralization, Focal 1 (2%) 1 (2%) 4 (7%) 2 (3%)
Nephropathy 1 (2%) 2 (3%) 19 (32%)
Cortex, Cyst 1 (2%)
Renal Tubule, Cyst 1 (2%)
Renal Tubule, Degeneration 1 (2%) 1 (2%)
Renal Tubule, Dilatation 1 (2%) 2 (3%)
Renal Tubule, Mineralization 1 (2%)
Renal Tubule, Regeneration 33 (56%) 33 (55%) 37 (64%) 30 (50%)
Urinary Bladder (58) (59) (55) (55)
Inflammation, Chronic, Focal 2 (3%) 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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