TDMS Study 05127-02 Pathology Tables
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
Facility: TSI Mason Research
Chemical CAS #: 10326279
Lock Date: 11/15/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 3| 2| 3| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3|
| 8| 8| 8| 8| 2| 4| 8| 8| 2| 8| 8| 2| 8| 8| 5| 8| 8| 8| 8| 7| 7| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + M + + + M A + + +|
Inflammation, Chronic, Focal | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Edema | 4 |
Hyperplasia, Lymphoid | 2 3 2 2 3 3 3 3 4 4 2 3 2 2 3 4 3|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | |
Eosinophilic Focus | X X |
Fatty Change | 1 3 |
Granuloma | 1 |
Hematopoietic Cell Proliferation | |
Hemorrhage, Focal | |
Inflammation, Chronic, Focal | |
Mineralization, Focal | 1 |
Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Inflammation, Chronic, Focal | |
Acinus, Atrophy | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3|
Bulla | 3 |
Cyst Epithelial Inclusion | |
Diverticulum | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
Diverticulum | 3 |
Erosion | 3 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 3| 2| 3| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3|
| 8| 8| 8| 8| 2| 4| 8| 8| 2| 8| 8| 2| 8| 8| 5| 8| 8| 8| 8| 7| 7| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tongue | + |
Necrosis, Focal | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Ventricle, Hypertrophy | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + I + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 4 |
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + + + + M + M + M + M M M + M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 4 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +|
Congestion | |
Cyst | X X X X X X X X|
Hemorrhage | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3 |
Dilatation | 3 3 3 4 4 2 4 |
Hemorrhage | 3 |
Mineralization | |
Necrosis | |
Thrombosis | X |
Endometrium, Hyperplasia, Cystic | 3 4 3 4 2 2 3 2 1 3 2 4 1 2 3 1 3 3 4|
Myometrium, Inflammation, Chronic, | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 3| 2| 3| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3|
| 8| 8| 8| 8| 2| 4| 8| 8| 2| 8| 8| 2| 8| 8| 5| 8| 8| 8| 8| 7| 7| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Focal | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + +|
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hyperplasia, Neutrophil | 4 |
Myelofibrosis | 3 3 3 2 1 1 1 2 2 3 4 2 3 1 3 2 3 3|
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 4 4 3 4 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + M + M + M + + + + + + + M + + + + M + + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + M + + + + + + + + + +|
Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Mineralization, Focal | 2 |
Mineralization | 3 3 3 2 2 1 1 3 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 3| 2| 3| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3|
| 8| 8| 8| 8| 2| 4| 8| 8| 2| 8| 8| 2| 8| 8| 5| 8| 8| 8| 8| 7| 7| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 2 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Artery, Internal Ear, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 4 2 |
Glomerulosclerosis | |
Mineralization | 1 1|
Renal Tubule, Regeneration | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 4| 7|
DAY ON TEST | 6| 3| 3| 3| 4| 3| 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 6| 6| 9| 3| 3| 3| 6| 3|
| 2| 8| 7| 7| 1| 7| 7| 8| 7| 7| 2| 4| 7| 4| 7| 8| 7| 2| 1| 8| 8| 8| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + M + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 2 3 3 2 2 4 2 2 3 2 3 4 3 3 2 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X |
Clear Cell Focus | |
Eosinophilic Focus | X X |
Fatty Change | 2 1 1 |
Granuloma | |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage, Focal | |
Inflammation, Chronic, Focal | 2 |
Mineralization, Focal | |
Necrosis, Focal | 4 3 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic, Focal | 1 2 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 2 3 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Bulla | |
Cyst Epithelial Inclusion | X |
Diverticulum | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Erosion | 3 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 4| 7|
DAY ON TEST | 6| 3| 3| 3| 4| 3| 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 6| 6| 9| 3| 3| 3| 6| 3|
| 2| 8| 7| 7| 1| 7| 7| 8| 7| 7| 2| 4| 7| 4| 7| 8| 7| 2| 1| 8| 8| 8| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
Mucosa, Hyperplasia | 4 |
__________________________________________________________________________|
Tongue | |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Ventricle, Hypertrophy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 2 2 |
__________________________________________________________________________|
Parathyroid Gland | M + M M M + + + + + + + + + + M + + M M M M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + I + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia, Focal | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | X X X X X |
Hemorrhage | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Dilatation | 3 4 4 4 4 2 4 |
Hemorrhage | 3 |
Mineralization | |
Necrosis | |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 2 2 3 3 3 3 2 4 4 3 2 2 2 2 3 2 3 4 3 2 4|
Myometrium, Inflammation, Chronic, | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 4| 7|
DAY ON TEST | 6| 3| 3| 3| 4| 3| 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 6| 6| 9| 3| 3| 3| 6| 3|
| 2| 8| 7| 7| 1| 7| 7| 8| 7| 7| 2| 4| 7| 4| 7| 8| 7| 2| 1| 8| 8| 8| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + +|
Neutrophilia | 4 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | |
Hyperplasia, Neutrophil | 4 2 |
Myelofibrosis | 2 1 2 2 1 1 2 1 1 2 3 2 3|
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 1 4 3 4 3 2 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + M + + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + M + M + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Mineralization, Focal | 1 |
Mineralization | 3 1 3 2 3 2 3 3 3 1 2 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 4| 7|
DAY ON TEST | 6| 3| 3| 3| 4| 3| 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 6| 6| 9| 3| 3| 3| 6| 3|
| 2| 8| 7| 7| 1| 7| 7| 8| 7| 7| 2| 4| 7| 4| 7| 8| 7| 2| 1| 8| 8| 8| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 |
Inflammation, Chronic | 2 2 2 3 2 2 3 2 2 2 2 2 2 2 3 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Artery, Internal Ear, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Glomerulosclerosis | 3 |
Mineralization | |
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Chronic, Focal | 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 4| 5| 7| 7| 6| | |
DAY ON TEST | 3| 3| 7| 7| 6| 6| 8| 3| 3| 0| | |
| 7| 8| 3| 8| 4| 2| 0| 8| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 54 |
Inflammation, Chronic, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + | 58 |
Edema | | 1 4.0|
Hyperplasia, Lymphoid | 2 3 4 2 3 2 | 39 2.7|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + | 57 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + | 57 |
Hyperplasia, Lymphoid | 4 | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Basophilic Focus | | 3 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | | 4 |
Fatty Change | 2 1 2 | 8 1.6|
Granuloma | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage, Focal | 3 | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
Mineralization, Focal | | 1 1.0|
Necrosis, Focal | 4 | 5 3.4|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Inflammation, Chronic, Focal | 2 2 | 4 1.8|
Acinus, Atrophy | 4 | 2 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | 2 3 | 8 2.4|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Abscess | | 2 3.0|
Bulla | | 1 3.0|
Cyst Epithelial Inclusion | | 1 |
Diverticulum | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 4| 5| 7| 7| 6| | |
DAY ON TEST | 3| 3| 7| 7| 6| 6| 8| 3| 3| 0| | |
| 7| 8| 3| 8| 4| 2| 0| 8| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Diverticulum | | 1 3.0|
Erosion | 2 | 3 2.7|
Mineralization | 1 | 1 1.0|
Ulcer | 4 | 1 4.0|
Mucosa, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Necrosis, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Dilatation | 3 | 1 3.0|
Ventricle, Hypertrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 2 1 2 | 14 1.9|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 2 2 | 11 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 4 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Congestion | | 1 3.0|
Cyst | X X X X X | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 4| 5| 7| 7| 6| | |
DAY ON TEST | 3| 3| 7| 7| 6| 6| 8| 3| 3| 0| | |
| 7| 8| 3| 8| 4| 2| 0| 8| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 3 3.0|
Dilatation | 3 4 4 | 17 3.5|
Hemorrhage | | 2 3.0|
Mineralization | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
Thrombosis | | 1 |
Endometrium, Hyperplasia, Cystic | 4 4 1 2 3 1 3 3 | 48 2.7|
Myometrium, Inflammation, Chronic, | | |
Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + | 43 |
Neutrophilia | | 1 4.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Hyperplasia | 3 | 1 3.0|
Hyperplasia, Neutrophil | | 3 3.3|
Myelofibrosis | 3 1 1 2 2 3 | 37 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
Mediastinal, Congestion | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Depletion Lymphoid | 3 3 | 2 3.0|
Hematopoietic Cell Proliferation | 1 | 12 2.9|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + M + + + | 51 |
Depletion Lymphoid | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + | 54 |
Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 4| 5| 7| 7| 6| | |
DAY ON TEST | 3| 3| 7| 7| 6| 6| 8| 3| 3| 0| | |
| 7| 8| 3| 8| 4| 2| 0| 8| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 1 |
Mineralization, Focal | 2 1 | 4 1.5|
Mineralization | 3 1 3 2 2 | 27 2.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Degeneration, Hyaline | | 1 2.0|
Inflammation, Chronic, Focal | 2 3 | 10 2.1|
Inflammation, Chronic | 2 2 2 2 2 2 3 | 45 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Artery, Internal Ear, Inflammation, | | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Atrophy, Focal | | 2 3.0|
Glomerulosclerosis | | 1 3.0|
Mineralization | 4 | 3 2.0|
Renal Tubule, Regeneration | 2 | 6 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + | 57 |
Inflammation, Chronic, Focal | 2 | 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 2| 6| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3|
| 7| 1| 4| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 4 4 2 3 3 4 3 2 4 3 3 3 2|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Angiectasis | 4 3 |
Clear Cell Focus | X X |
Congestion | |
Eosinophilic Focus | X X |
Fatty Change | 1 2 4 2 2 1 |
Hematopoietic Cell Proliferation | 4 |
Mixed Cell Focus | |
Necrosis, Focal | 3 1 1 3 1 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Chronic | 4 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
Acanthosis | 4 |
Edema | 4 |
Hyperkeratosis | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic, Focal | |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 2| 6| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3|
| 7| 1| 4| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2|
Pericardium, Fibrosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Focal | |
Capsule, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 1 4 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + + M + + + + + M + + + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + M + + + + +|
Congestion | 2 |
Pars Distalis, Hyperplasia, Focal | 2 4|
Rathke's Cleft, Hemorrhage | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 2 |
C-Cell, Hyperplasia | 1 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Follicle, Hemorrhage | 3 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | 3 |
Cyst | |
Dilatation | 4 2 4 4 |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 3 3 2 2 3 4 2 3 3 4 4 3 3|
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 2| 6| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3|
| 7| 1| 4| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | 2 |
Myelofibrosis | 1 2 3 2 2 2 3 3 3 2 3 1 1 1 4 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
Lymphatic, Angiectasis | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + M + + + + + +|
Congestion | 4 |
Necrosis, Focal | |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Congestion | |
Depletion Lymphoid | 4 |
Hematopoietic Cell Proliferation | 4 3 3|
Hyperplasia, Lymphoid | 3 |
Necrosis, Focal | 4 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + M + + + + + + + +|
Depletion Lymphoid | |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + M + M + + M + + + + + + M M + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 1 2 |
Mineralization | 2 2 2 3 2 3 2 1 2 2 2 2 2|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | |
Alveolar Epithelium, Metaplasia | |
Peribronchial, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 2| 6| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3|
| 7| 1| 4| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Degeneration, Hyaline | 4 |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Atrophy, Focal | |
Congestion | |
Glomerulosclerosis | |
Nephropathy | |
Papilla, Necrosis | |
Renal Tubule, Degeneration | 4 |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Pigmentation, | |
Hemosiderin | |
Renal Tubule, Regeneration | 1 3 2 2 2|
__________________________________________________________________________|
Urinary Bladder | A + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 5| 3| 4| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 3| 3| 3| 3|
| 4| 7| 5| 5| 5| 6| 6| 5| 6| 6| 6| 6| 4| 6| 6| 6| 3| 6| 6| 6| 2| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + + + + M + + + A + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 1 4 2 3 2 2 2 2 2|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + A + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Angiectasis | |
Clear Cell Focus | X X|
Congestion | 2 |
Eosinophilic Focus | X X |
Fatty Change | 1 2 2 1 |
Hematopoietic Cell Proliferation | |
Mixed Cell Focus | X |
Necrosis, Focal | |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 2 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Edema | |
Hyperkeratosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic, Focal | |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 5| 3| 4| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 3| 3| 3| 3|
| 4| 7| 5| 5| 5| 6| 6| 5| 6| 6| 6| 6| 4| 6| 6| 6| 3| 6| 6| 6| 2| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Pericardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Focal | 2 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + M + + M + M + + + + + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + I + + + + + + + + + + + +|
Congestion | 4 |
Pars Distalis, Hyperplasia, Focal | 2 3 2 2|
Rathke's Cleft, Hemorrhage | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
Follicle, Hemorrhage | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 2 4 |
Cyst | X |
Dilatation | 4 4 3 4 3 4 4 4 3 4 |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 4 4 2 4 3 4 2 4 4 3 3 4 3 4 2 2 4 4 3|
Lumen, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 5| 3| 4| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 3| 3| 3| 3|
| 4| 7| 5| 5| 5| 6| 6| 5| 6| 6| 6| 6| 4| 6| 6| 6| 3| 6| 6| 6| 2| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | 4 3 |
Myelofibrosis | 3 3 2 4 3 4 2 1 1 3 2 2 2 4 1|
__________________________________________________________________________|
Lymph Node | +|
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Infiltration Cellular, Plasma Cell | 4 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Necrosis, Focal | 2 |
Lymphatic, Angiectasis | 3 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 4 |
Congestion | 3 3 2 |
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 4 4 2 4 |
Hyperplasia, Lymphoid | |
Necrosis, Focal | 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +|
Depletion Lymphoid | 4 |
Necrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M M + + + + + M + M + M + + M + + M + + M|
__________________________________________________________________________|
Skin | + + A + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
Mineralization | 1 1 2 2 3 3 3 3 2 3 3 2 3 3 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 |
Alveolar Epithelium, Metaplasia | 1 |
Peribronchial, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 5| 3| 4| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 3| 3| 3| 3|
| 4| 7| 5| 5| 5| 6| 6| 5| 6| 6| 6| 6| 4| 6| 6| 6| 3| 6| 6| 6| 2| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Degeneration, Hyaline | |
Inflammation, Acute | 2 |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 |
Atrophy, Focal | |
Congestion | 3 |
Glomerulosclerosis | 2 |
Nephropathy | |
Papilla, Necrosis | 4 |
Renal Tubule, Degeneration | 2 |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 |
Renal Tubule, Regeneration | 2 |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 4| 7| 3| 6| 7| 3| 7| 4| 7| 5| | |
DAY ON TEST | 6| 3| 7| 0| 3| 7| 3| 6| 1| 6| | |
| 4| 6| 3| 7| 6| 7| 6| 4| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A |
500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | M + + A + + + + + + | 55 |
Dilatation | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + A + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + A + | 58 |
Hyperplasia, Lymphoid | 3 3 1 3 | 30 2.7|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + A + | 57 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + A + | 57 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + A M | 55 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 4.0|
Angiectasis | | 2 3.5|
Clear Cell Focus | | 4 |
Congestion | | 1 2.0|
Eosinophilic Focus | | 4 |
Fatty Change | 2 2 | 12 1.8|
Hematopoietic Cell Proliferation | | 1 4.0|
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 6 1.8|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Fat, Necrosis | | 5 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Chronic | | 1 4.0|
Duct, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Inflammation, Chronic, Focal | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + | 58 |
Acanthosis | 4 | 2 4.0|
Edema | | 1 4.0|
Hyperkeratosis | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + | 58 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 4| 7| 3| 6| 7| 3| 7| 4| 7| 5| | |
DAY ON TEST | 6| 3| 7| 0| 3| 7| 3| 6| 1| 6| | |
| 4| 6| 3| 7| 6| 7| 6| 4| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A |
500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 2 |
Hyperkeratosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 2 2.0|
Pericardium, Fibrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Hyperplasia, Focal | | 1 2.0|
Capsule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + I + + + + I + + | 55 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | 2 1 | 14 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + + M + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Congestion | | 2 3.0|
Pars Distalis, Hyperplasia, Focal | 3 | 7 2.6|
Rathke's Cleft, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Inflammation, Acute, Focal | | 1 2.0|
C-Cell, Hyperplasia | | 2 1.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Cyst | X X | 10 |
Follicle, Hemorrhage | | 2 3.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | 3 | 2 3.0|
Atrophy | 3 | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 4| 7| 3| 6| 7| 3| 7| 4| 7| 5| | |
DAY ON TEST | 6| 3| 7| 0| 3| 7| 3| 6| 1| 6| | |
| 4| 6| 3| 7| 6| 7| 6| 4| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A |
500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 1 |
Dilatation | | 14 3.6|
Thrombosis | X | 1 |
Endometrium, Hyperplasia, Cystic | 3 4 3 2 3 4 | 43 3.1|
Lumen, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Atrophy | | 1 4.0|
Hyperplasia, Neutrophil | 3 | 4 3.0|
Myelofibrosis | 2 3 2 | 35 2.3|
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Infiltration Cellular, Plasma Cell | | 1 4.0|
Lymphatic, Angiectasis | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | I + + A + + + + + + | 55 |
Congestion | 4 | 2 4.0|
Necrosis, Focal | | 1 2.0|
Lymphatic, Angiectasis | | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | | 2 4.0|
Congestion | | 3 2.7|
Depletion Lymphoid | | 2 3.5|
Hematopoietic Cell Proliferation | 3 3 4 2 | 11 3.3|
Hyperplasia, Lymphoid | | 1 3.0|
Necrosis, Focal | | 2 3.5|
Pigmentation, Hemosiderin | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + M + + M M M M + | 52 |
Depletion Lymphoid | | 1 4.0|
Necrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + + + + + M M | 41 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 4| 7| 3| 6| 7| 3| 7| 4| 7| 5| | |
DAY ON TEST | 6| 3| 7| 0| 3| 7| 3| 6| 1| 6| | |
| 4| 6| 3| 7| 6| 7| 6| 4| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A |
500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization, Focal | 2 | 4 1.8|
Mineralization | 2 1 | 30 2.2|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 2.5|
Hemorrhage | | 1 2.0|
Alveolar Epithelium, Metaplasia | | 1 1.0|
Peribronchial, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Degeneration, Hyaline | | 1 4.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic, Focal | 2 | 3 2.0|
Inflammation, Chronic | 2 2 2 2 2 2 2 | 44 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | | 2 3.5|
Atrophy, Focal | 2 3 | 2 2.5|
Congestion | | 1 3.0|
Glomerulosclerosis | | 1 2.0|
Nephropathy | 1 1 | 2 1.0|
Papilla, Necrosis | | 1 4.0|
Renal Tubule, Degeneration | | 2 3.0|
Renal Tubule, Dilatation | | 2 2.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | | 1 3.0|
Renal Tubule, Regeneration | | 6 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + M + + A + | 53 |
Inflammation, Chronic, Focal | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 6| 4| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 6| 3| 8| 3| 4| 0| 6| 3| 3| 3| 3| 1| 3| 0| 6| 6| 3| 3| 6| 3| 3|
| 9| 6| 6| 6| 4| 6| 5| 6| 5| 7| 2| 6| 6| 6| 6| 6| 6| 5| 2| 2| 6| 6| 0| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
1250 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 4 4 4 3 3 3 3 4 3 3 2|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 4 3|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X X |
Fatty Change | 2 1 2 2 2 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage, Focal | |
Infarct | |
Inflammation, Chronic, Focal | |
Mixed Cell Focus | X X |
Necrosis, Focal | |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 2 |
Fat, Necrosis | 3 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Hyperkeratosis | 3 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Mineralization | 2 |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 6| 4| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 6| 3| 8| 3| 4| 0| 6| 3| 3| 3| 3| 1| 3| 0| 6| 6| 3| 3| 6| 3| 3|
| 9| 6| 6| 6| 4| 6| 5| 6| 5| 7| 2| 6| 6| 6| 6| 6| 6| 5| 2| 2| 6| 6| 0| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
1250 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 |
Edema | |
Inflammation, Chronic, Focal | |
Valve, Pigmentation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Focal | |
Zona Reticularis, Hemorrhage | 3 3 2 |
Zona Reticularis, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + I + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 1 2 3 2|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + M M M + + + + M M + + + + + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + M + +|
Angiectasis | |
Cyst | X X X X X X |
Thrombosis | |
Follicle, Hemorrhage | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Atrophy | 2 |
Dilatation | 3 4 4 4 4 4 4 |
Hemorrhage | 3 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 4 2 2 1 3 4 3 3 3 2 3 2 3|
Endometrium, Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 6| 4| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 6| 3| 8| 3| 4| 0| 6| 3| 3| 3| 3| 1| 3| 0| 6| 6| 3| 3| 6| 3| 3|
| 9| 6| 6| 6| 4| 6| 5| 6| 5| 7| 2| 6| 6| 6| 6| 6| 6| 5| 2| 2| 6| 6| 0| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
1250 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | + + + + +|
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + I + + + + + +|
Hyperplasia, Neutrophil | 3 2 |
Myelofibrosis | 2 3 1 2 3 4 4 4 2 1 1 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Infiltration Cellular, | |
Plasma Cell | |
Lumbar, Inflammation, Acute | |
Lumbar, Lymphatic, Angiectasis | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + M + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 4 2 3 |
Hyperplasia, Lymphoid | 4 |
Infarct | |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + M + + + + + + + + + + + + + + +|
Necrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
Mineralization | 2 2 2 3 3 3 3 2 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + M + + + + + + + + + + + +|
Degeneration, Hyaline | 1 |
Inflammation, Chronic, Focal | 2 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 6| 4| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 6| 3| 8| 3| 4| 0| 6| 3| 3| 3| 3| 1| 3| 0| 6| 6| 3| 3| 6| 3| 3|
| 9| 6| 6| 6| 4| 6| 5| 6| 5| 7| 2| 6| 6| 6| 6| 6| 6| 5| 2| 2| 6| 6| 0| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
1250 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2|
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Casts | |
Congestion | 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Focal | |
Metaplasia, Osseous | |
Mineralization | |
Nephropathy | |
Renal Tubule, Dilatation | |
Renal Tubule, Regeneration | 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 6| 0| 2| 2| 3| 6| 2| 1| 3| 3| 6| 3| 3| 3| 8| 3| 6| 3| 6| 3| 3|
| 6| 6| 0| 6| 2| 9| 7| 3| 6| 4| 1| 4| 5| 5| 2| 5| 5| 5| 0| 5| 2| 5| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1250 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + A + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Dilatation | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + A + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 3 4 4 2 4 4 3 4 4 2 2|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Angiectasis | 2 |
Basophilic Focus | X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X |
Fatty Change | 2 1 1 1 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage, Focal | |
Infarct | 4 |
Inflammation, Chronic, Focal | 1 |
Mixed Cell Focus | |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Mesentery | |
Fibrosis | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
Diverticulum | |
Hyperkeratosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + M + + + + + + + + + +|
Erosion | |
Mineralization | 2 |
Necrosis, Focal | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 6| 0| 2| 2| 3| 6| 2| 1| 3| 3| 6| 3| 3| 3| 8| 3| 6| 3| 6| 3| 3|
| 6| 6| 0| 6| 2| 9| 7| 3| 6| 4| 1| 4| 5| 5| 2| 5| 5| 5| 0| 5| 2| 5| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1250 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Angiectasis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Edema | 2 |
Inflammation, Chronic, Focal | |
Valve, Pigmentation | 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Focal | 2 2 |
Zona Reticularis, Hemorrhage | |
Zona Reticularis, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + I + + + + + + + I + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M M + M + M + M M + + M + M + M + M M + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + M M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 4 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | X |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X X X |
Thrombosis | 4 |
Follicle, Hemorrhage | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 4 |
Atrophy | 3 2 |
Dilatation | 4 4 3 |
Hemorrhage | |
Endometrium, Hyperplasia, Cystic | 3 2 2 4 2 2 3 2 2 4 1 3 4 1 3 1 3 2 3|
Endometrium, Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 6| 0| 2| 2| 3| 6| 2| 1| 3| 3| 6| 3| 3| 3| 8| 3| 6| 3| 6| 3| 3|
| 6| 6| 0| 6| 2| 9| 7| 3| 6| 4| 1| 4| 5| 5| 2| 5| 5| 5| 0| 5| 2| 5| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1250 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + |
Neutrophilia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
Myelofibrosis | 3 2 3 4 2 3 2 2 3 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + +|
Lumbar, Infiltration Cellular, | |
Plasma Cell | 4 |
Lumbar, Inflammation, Acute | 3 |
Lumbar, Lymphatic, Angiectasis | 4 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + M + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 4 4 2 4 4 1 |
Hyperplasia, Lymphoid | |
Infarct | 4 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M M + + + + + + + + + + + + + +|
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
Mineralization | 2 2 2 2 2 2 3 2 3 3 1 2 3 3 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 |
Inflammation, Chronic, Focal | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 6| 0| 2| 2| 3| 6| 2| 1| 3| 3| 6| 3| 3| 3| 8| 3| 6| 3| 6| 3| 3|
| 6| 6| 0| 6| 2| 9| 7| 3| 6| 4| 1| 4| 5| 5| 2| 5| 5| 5| 0| 5| 2| 5| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1250 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 3 2 1 2 2 1 1 2 2 2 2 2 2 2 2|
Metaplasia, Squamous | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 |
Casts | |
Congestion | |
Hyperplasia, Lymphoid | |
Inflammation, Focal | |
Metaplasia, Osseous | |
Mineralization | 1 |
Nephropathy | |
Renal Tubule, Dilatation | |
Renal Tubule, Regeneration | 2 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + A + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + + + | 56 |
Autolysis | | 1 3.0|
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | 4 3 3 3 3 3 3 4 4 | 35 3.3|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | 3 | 3 3.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis, Focal | | 1 2.0|
Angiectasis | | 1 2.0|
Basophilic Focus | | 2 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | X X | 9 |
Fatty Change | | 10 1.6|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage, Focal | 3 | 1 3.0|
Infarct | | 1 4.0|
Inflammation, Chronic, Focal | 3 | 2 2.0|
Mixed Cell Focus | | 2 |
Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fibrosis | | 1 2.0|
Fat, Necrosis | 3 | 4 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Cyst | | 1 |
Inflammation, Chronic, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | 2 | 7 2.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Diverticulum | | 1 2.0|
Hyperkeratosis | | 2 2.5|
Ulcer | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Erosion | | 1 2.0|
Mineralization | | 2 2.0|
Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
Angiectasis | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 2 1.5|
Edema | | 1 2.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
Valve, Pigmentation | | 2 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hyperplasia, Focal | | 2 2.0|
Zona Reticularis, Hemorrhage | | 3 2.7|
Zona Reticularis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 2 1 1 | 13 1.6|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 40 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Pars Distalis, Hyperplasia, Focal | 3 | 6 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Cyst | | 1 |
Follicular Cell, Hyperplasia | | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Angiectasis | 3 | 1 3.0|
Cyst | X | 13 |
Thrombosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Follicle, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 3 4.0|
Atrophy | 3 | 4 2.5|
Dilatation | 4 4 4 4 4 | 15 3.9|
Hemorrhage | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 3 4 4 3 3 | 42 2.7|
Endometrium, Metaplasia, Squamous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + | 25 |
Neutrophilia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Hyperplasia, Neutrophil | | 2 2.5|
Myelofibrosis | 2 1 3 3 2 3 | 33 2.4|
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Lumbar, Infiltration Cellular, | | |
Plasma Cell | 4 | 2 4.0|
Lumbar, Inflammation, Acute | | 1 3.0|
Lumbar, Lymphatic, Angiectasis | 3 | 2 3.5|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Congestion | 3 | 2 3.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 4 | 13 3.2|
Hyperplasia, Lymphoid | 3 | 2 3.5|
Infarct | | 1 4.0|
Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Necrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization, Focal | 1 | 3 1.7|
Mineralization | 2 1 1 | 30 2.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Degeneration, Hyaline | | 2 1.5|
Inflammation, Chronic, Focal | 2 | 9 1.9|
Inflammation, Chronic | 2 2 2 2 2 3 2 2 2 | 41 2.0|
Metaplasia, Squamous | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Atrophy, Focal | 3 | 4 2.3|
Casts | X | 1 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Focal | 2 | 1 2.0|
Metaplasia, Osseous | 3 | 1 3.0|
Mineralization | | 1 1.0|
Nephropathy | 2 | 1 2.0|
Renal Tubule, Dilatation | 2 | 1 2.0|
Renal Tubule, Regeneration | 1 2 | 9 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic, Focal | | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 1| 3| 2| 2| 2| 4| 6| 7| 4| 7| 4| 1| 7| 6| 2| 1| 3| 1| 7| 1| 1| 1| 1|
DAY ON TEST | 3| 3| 4| 9| 1| 3| 0| 6| 4| 3| 6| 3| 6| 4| 3| 5| 2| 3| 1| 5| 3| 7| 0| 7| 1|
| 5| 5| 2| 5| 3| 0| 3| 4| 3| 5| 2| 5| 2| 2| 5| 8| 5| 5| 7| 7| 5| 7| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
2500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + M + + + + + + + + I + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + A +|
Hyperplasia, Lymphoid | 2 3 2 2 3 3 4 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + M + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Congestion | 1 |
Eosinophilic Focus | |
Fatty Change | 2 1 2 |
Hemorrhage, Focal | |
Mixed Cell Focus | X |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis | 4 3 |
Diverticulum | |
Hyperkeratosis | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + M + + + + + + + + + + + + + + + + + +|
Zona Reticularis, Degeneration, Fatty| 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 1| 3| 2| 2| 2| 4| 6| 7| 4| 7| 4| 1| 7| 6| 2| 1| 3| 1| 7| 1| 1| 1| 1|
DAY ON TEST | 3| 3| 4| 9| 1| 3| 0| 6| 4| 3| 6| 3| 6| 4| 3| 5| 2| 3| 1| 5| 3| 7| 0| 7| 1|
| 5| 5| 2| 5| 3| 0| 3| 4| 3| 5| 2| 5| 2| 2| 5| 8| 5| 5| 7| 7| 5| 7| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
2500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 1 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M + + + + M + M + M + + + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + I + + + + M + + + + + + + + + M M|
Congestion | |
Pars Distalis, Hyperplasia, Focal | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + M + + +|
Atrophy | |
Congestion | 2 |
Cyst | X X X |
Hemorrhage | 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 3 4 3 3 3 4 4 4|
Dilatation | 4 4 |
Hemorrhage | |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 4 4 2 2 4 3 3 3 2 2 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + I + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | |
Hyperplasia, Neutrophil | |
Myelofibrosis | 4 2 1 2 2 3 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M M M + M + M + M + + + + M + + + + + M +|
Depletion Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + M M M + + + + + + + M M + + + + + + M M M|
Angiectasis | |
Congestion | 2 |
Depletion Lymphoid | 3 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 3 3 3 2 2 4 |
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 1| 3| 2| 2| 2| 4| 6| 7| 4| 7| 4| 1| 7| 6| 2| 1| 3| 1| 7| 1| 1| 1| 1|
DAY ON TEST | 3| 3| 4| 9| 1| 3| 0| 6| 4| 3| 6| 3| 6| 4| 3| 5| 2| 3| 1| 5| 3| 7| 0| 7| 1|
| 5| 5| 2| 5| 3| 0| 3| 4| 3| 5| 2| 5| 2| 2| 5| 8| 5| 5| 7| 7| 5| 7| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
2500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 1 1|
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | + + + + M M + + M + + + + + + + + + + M + + M + M|
Depletion Lymphoid | 3 3 3 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M + + + + + + + + M + + M M M M + + + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
Mineralization | 2 3 1 2 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hemorrhage | 3 |
Alveolar Epithelium, Metaplasia | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic, Focal | 2 2 2 |
Inflammation, Chronic | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 |
Metaplasia, Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
Casts | 1 |
Crystals | 2 3 3 2 3 2 2 2 3 2 1 2 2 3 3 1|
Mineralization | |
Nephropathy | 4 4 4 3 4 4 3 4 4 4 3 4 3 4 2 4|
Renal Tubule, Dilatation | |
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + A +|
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 2| 6| 1| 1| 1| 2| 6| 7| 2| 7| 5| 2| 6| 7| 4| 7| 5| 7| 6| 7| 7| 7| 6| 1| 4|
DAY ON TEST | 3| 7| 7| 0| 0| 9| 1| 3| 4| 3| 8| 2| 7| 3| 6| 1| 6| 3| 5| 2| 3| 2| 4| 3| 6|
| 4| 4| 1| 8| 4| 8| 7| 5| 8| 5| 5| 1| 3| 5| 4| 8| 1| 5| 8| 3| 5| 0| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
2500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A + + A + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 3 1 3 3 3 3 3 3 2 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + A + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + A + + A + + + + + M M + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Congestion | |
Eosinophilic Focus | X |
Fatty Change | 4 4 |
Hemorrhage, Focal | 3 |
Mixed Cell Focus | |
Necrosis, Focal | 1 4 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + + + +|
Abscess | 2 |
Acanthosis | 2 3 3 |
Diverticulum | 3 |
Hyperkeratosis | |
Ulcer | 4 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Zona Reticularis, Degeneration, Fatty| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + I + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 2| 6| 1| 1| 1| 2| 6| 7| 2| 7| 5| 2| 6| 7| 4| 7| 5| 7| 6| 7| 7| 7| 6| 1| 4|
DAY ON TEST | 3| 7| 7| 0| 0| 9| 1| 3| 4| 3| 8| 2| 7| 3| 6| 1| 6| 3| 5| 2| 3| 2| 4| 3| 6|
| 4| 4| 1| 8| 4| 8| 7| 5| 8| 5| 5| 1| 3| 5| 4| 8| 1| 5| 8| 3| 5| 0| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
2500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 3 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M M + + + M + + M + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + M + + I + + + + + + + + + + + + + + + + + M + +|
Congestion | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Congestion | |
Cyst | X X X X X X X |
Hemorrhage | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 4 3 4 2 2 3 3 |
Dilatation | 3 4 |
Hemorrhage | 3 |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 4 4 1 2 2 4 2 2 3 4 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + I + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | 2 |
Hyperplasia, Neutrophil | 3 |
Myelofibrosis | 2 1 2 3 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + I + M + + + + + M + + + + + + + + + + + + M +|
Depletion Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M M + + + + + + M + + + + M + + + + + + M +|
Angiectasis | 4 |
Congestion | |
Depletion Lymphoid | 4 3 4 3 3 |
__________________________________________________________________________|
Spleen | + + M + M + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Depletion Lymphoid | 4 4 3 |
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 2| 6| 1| 1| 1| 2| 6| 7| 2| 7| 5| 2| 6| 7| 4| 7| 5| 7| 6| 7| 7| 7| 6| 1| 4|
DAY ON TEST | 3| 7| 7| 0| 0| 9| 1| 3| 4| 3| 8| 2| 7| 3| 6| 1| 6| 3| 5| 2| 3| 2| 4| 3| 6|
| 4| 4| 1| 8| 4| 8| 7| 5| 8| 5| 5| 1| 3| 5| 4| 8| 1| 5| 8| 3| 5| 0| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
2500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 4 4 4 4 1 2|
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + M M + + + + M + M + + + + + + + + I + M + + +|
Depletion Lymphoid | 3 4 4 4 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + M + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + I + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2|
Mineralization | 3 2 1 3 2 2 3 3 2 3 2 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 |
Alveolar Epithelium, Metaplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 2 2|
Inflammation, Chronic | 2 1 2 2 2 2 2 2 2 2 2 3 2 2 |
Metaplasia, Squamous | 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Casts | |
Crystals | 3 1 1 1 2 2 3 1 2 3 1 2 2 2 2 |
Mineralization | 2 1 |
Nephropathy | 3 4 4 4 4 4 4 3 4 4 3 2 4 4 4 4 |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | A + + + + A + + A + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 6| 4| 1| 4| 7| 7| 7| 6| 2| 4| | |
DAY ON TEST | 6| 6| 5| 1| 3| 3| 0| 7| 4| 3| | |
| 6| 2| 0| 2| 5| 5| 7| 9| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | A |
2500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + A | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 55 |
Hyperplasia, Lymphoid | 3 3 2 3 | 23 2.7|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M + + + + + M | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + M | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 1 |
Clear Cell Focus | | 2 |
Congestion | | 1 1.0|
Eosinophilic Focus | X | 2 |
Fatty Change | 2 1 | 7 2.3|
Hemorrhage, Focal | | 1 3.0|
Mixed Cell Focus | | 1 |
Necrosis, Focal | 3 | 4 2.5|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Congestion | | 1 1.0|
Inflammation, Chronic, Focal | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Abscess | | 1 2.0|
Acanthosis | | 5 3.0|
Diverticulum | 3 | 2 3.0|
Hyperkeratosis | | 1 3.0|
Ulcer | 3 | 4 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A | 59 |
Erosion | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 6| 4| 1| 4| 7| 7| 7| 6| 2| 4| | |
DAY ON TEST | 6| 6| 5| 1| 3| 3| 0| 7| 4| 3| | |
| 6| 2| 0| 2| 5| 5| 7| 9| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | A |
2500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | M + + + + + + + + + | 58 |
Zona Reticularis, Degeneration, Fatty| | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | M + + + + + + + M + | 56 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 2 | 9 1.9|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M M M + M I M | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 53 |
Congestion | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 3 | 6 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 2 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Atrophy | | 1 3.0|
Congestion | | 1 2.0|
Cyst | | 10 |
Hemorrhage | | 3 2.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Atrophy | 3 | 20 3.3|
Dilatation | 4 4 | 6 3.8|
Hemorrhage | | 1 3.0|
Endometrium, Cyst | X X | 2 |
Endometrium, Hyperplasia, Cystic | 2 4 4 4 | 26 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 13 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Hyperplasia, Megakaryocyte | | 1 2.0|
Hyperplasia, Neutrophil | 2 2 | 3 2.3|
Myelofibrosis | 1 | 18 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 6| 4| 1| 4| 7| 7| 7| 6| 2| 4| | |
DAY ON TEST | 6| 6| 5| 1| 3| 3| 0| 7| 4| 3| | |
| 6| 2| 0| 2| 5| 5| 7| 9| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | A |
2500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + M + | 46 |
Depletion Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + | 45 |
Angiectasis | | 1 4.0|
Congestion | | 1 2.0|
Depletion Lymphoid | 2 | 10 2.9|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Congestion | 3 | 2 2.5|
Depletion Lymphoid | 3 3 | 11 3.1|
Fibrosis | 2 | 3 2.0|
Hematopoietic Cell Proliferation | 2 4 | 10 2.7|
Pigmentation, Hemosiderin | 1 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | I + + + + + + M M M | 44 |
Depletion Lymphoid | 3 | 12 3.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + M + | 47 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization, Focal | | 2 2.0|
Mineralization | 3 2 3 2 | 24 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 1.5|
Hemorrhage | | 2 2.5|
Alveolar Epithelium, Metaplasia | 2 | 3 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Degeneration, Hyaline | | 1 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic, Focal | 2 | 6 2.0|
Inflammation, Chronic | 1 2 1 3 2 2 1 | 36 1.9|
Metaplasia, Squamous | | 4 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 6| 4| 1| 4| 7| 7| 7| 6| 2| 4| | |
DAY ON TEST | 6| 6| 5| 1| 3| 3| 0| 7| 4| 3| | |
| 6| 2| 0| 2| 5| 5| 7| 9| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | A |
2500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Atrophy, Focal | | 1 1.0|
Casts | | 1 1.0|
Crystals | 3 2 1 1 1 | 36 2.0|
Mineralization | | 2 1.5|
Nephropathy | 4 4 3 3 4 | 37 3.6|
Renal Tubule, Dilatation | 3 | 2 2.0|
Renal Tubule, Regeneration | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A | 54 |
Inflammation, Chronic, Focal | 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 5| 3| 9| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 3|
| 7| 1| 2| 2| 2| 2| 2| 1| 2| 6| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + + + + M I A M + +|
Dilatation | 3 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + M + + M + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + A + + M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + M + + A + + +|
Hyperplasia, Lymphoid | 3 3 4 3 4 3 3 2 2 3 2 3 3 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | X X X X X X|
Fatty Change | 3 2 |
Hematopoietic Cell Proliferation | 2|
Necrosis, Focal | 2 4 |
Nuclear Alteration | 4 |
Thrombosis | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Necrosis | |
__________________________________________________________________________|
Pharynx | +|
Developmental Malformation | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Diverticulum | |
Hyperkeratosis | |
Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia, Focal | |
Metaplasia, Squamous | |
__________________________________________________________________________|
Tongue | + |
Depletion Cellular | 2 |
Pigmentation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 5| 3| 9| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 3|
| 7| 1| 2| 2| 2| 2| 2| 1| 2| 6| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Dilatation | |
Mineralization | |
Perivascular, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 3 2 4 2 1 |
Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 3 3 2 2 1 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + M + M + M M + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + M + + + + + + + + +|
Congestion | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X X X X X X X X X X X|
Cyst, Multiple | |
Cyst, Two | X X |
Ectasia | 4 4 4 4 4 4 4 4 3 3 4 4|
Inflammation, Acute, Focal | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Chronic | 3 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 4 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 2|
__________________________________________________________________________|
Lymph Node | + |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 5| 3| 9| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 3|
| 7| 1| 2| 2| 2| 2| 2| 1| 2| 6| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | M I + + + + + + + + + + + + + + M M + + + M + + M|
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Congestion | 2 3 3 |
Hyperplasia, Lymphoid | 4 |
Infiltration Cellular, Plasma Cell | 4|
Necrosis, Focal | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 3 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + I + + + + + + + M|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
Mineralization | 3 3 3 2 3 2 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Alveolar Epithelium, Metaplasia | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 X |
Mineralization, Focal | |
Mineralization | 1 1 1 1 1 1 2 2 1 |
Nephropathy | |
Cortex, Cyst | X |
Renal Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 5| 3| 9| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 3|
| 7| 1| 2| 2| 2| 2| 2| 1| 2| 6| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 1 2 1 2 2 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 0| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 1|
| 7| 6| 1| 7| 1| 1| 1| 1| 1| 1| 7| 1| 9| 3| 1| 0| 0| 0| 1| 1| 0| 1| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
Dilatation | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 4 3 3 3 2 3 4 4 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X |
Fatty Change | 3 3 2 2 2 1 |
Hematopoietic Cell Proliferation | |
Necrosis, Focal | 2 |
Nuclear Alteration | |
Thrombosis | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Necrosis | 3 |
__________________________________________________________________________|
Pharynx | |
Developmental Malformation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Diverticulum | 3 |
Hyperkeratosis | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia, Focal | |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Tongue | +|
Depletion Cellular | |
Pigmentation | 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 0| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 1|
| 7| 6| 1| 7| 1| 1| 1| 1| 1| 1| 7| 1| 9| 3| 1| 0| 0| 0| 1| 1| 0| 1| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Dilatation | 3 3 |
Mineralization | 2 |
Perivascular, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 3 2 1 |
Hyperplasia | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + + + M + + + + + + + + + I + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 4 2 3 2 3 2 4 4 3|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + M M + M + + + + M + + M + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Congestion | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Abscess | 2 |
Cyst | X X X X |
Cyst, Multiple | X |
Cyst, Two | X |
Ectasia | 4 4 4 4 4 4 4 4 |
Inflammation, Acute, Focal | 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic | 2 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4 4 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 0| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 1|
| 7| 6| 1| 7| 1| 1| 1| 1| 1| 1| 7| 1| 9| 3| 1| 0| 0| 0| 1| 1| 0| 1| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | I + + I + M + + M M + + + + + + + M + + M M + + M|
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 2 |
Infiltration Cellular, Plasma Cell | |
Necrosis, Focal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 |
__________________________________________________________________________|
Thymus | + M + + M + + + + + + + + M + + M M + + + I + + I|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M + M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
Mineralization | 2 2 2 3 3 2 2 1 3 2 2 2 3 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Alveolar Epithelium, Metaplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 |
Inflammation, Chronic | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Mineralization, Focal | 1 |
Mineralization | 2 2 1 1 2 1 2 1 2 1 1 2 1|
Nephropathy | 1 |
Cortex, Cyst | |
Renal Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 0| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 1|
| 7| 6| 1| 7| 1| 1| 1| 1| 1| 1| 7| 1| 9| 3| 1| 0| 0| 0| 1| 1| 0| 1| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 1 1 1 1 1 2 1 1 1 1 2 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| | |
| 9| 0| 0| 0| 1| 0| 0| 0| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + + + + + + + | 57 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + + + + | 53 |
Dilatation | | 3 3.7|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + | 57 |
Hyperplasia, Lymphoid | 3 4 3 3 2 3 | 29 3.0|
Serosa, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A M + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 |
Clear Cell Focus | X | 8 |
Eosinophilic Focus | | 9 |
Fatty Change | 2 | 9 2.2|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis, Focal | 2 | 4 2.5|
Nuclear Alteration | | 1 4.0|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Inflammation, Chronic | 2 | 1 2.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + | 59 |
Serosa, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Developmental Malformation | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + + + + + | 59 |
Acanthosis | | 1 3.0|
Diverticulum | | 1 3.0|
Hyperkeratosis | | 1 2.0|
Ulcer | | 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + | 59 |
Cyst Epithelial Inclusion | X | 1 |
Hyperplasia, Focal | 3 | 1 3.0|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| | |
| 9| 0| 0| 0| 1| 0| 0| 0| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Depletion Cellular | | 1 2.0|
Pigmentation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Dilatation | 3 | 3 3.0|
Mineralization | | 1 2.0|
Perivascular, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + M + + + + + + + | 58 |
Hyperplasia, Focal | 3 | 15 2.1|
Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + M + + + + + + + | 55 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + + + | 59 |
Hyperplasia | 2 4 4 | 27 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + M M + | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + | 56 |
Congestion | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 34 |
Abscess | | 1 2.0|
Cyst | X X | 17 |
Cyst, Multiple | | 1 |
Cyst, Two | | 3 |
Ectasia | 3 | 21 3.9|
Inflammation, Acute, Focal | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Inflammation, Chronic, Focal | | 1 1.0|
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| | |
| 9| 0| 0| 0| 1| 0| 0| 0| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Artery, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + A + + + + + + + | 59 |
Dilatation | 4 | 11 3.8|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Bone Marrow | + + A + + + + + + + | 59 |
Hyperplasia, Neutrophil | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + A M + M + M + + | 41 |
Lymphatic, Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Congestion | | 3 2.7|
Hyperplasia, Lymphoid | 3 | 4 3.0|
Infiltration Cellular, Plasma Cell | | 1 4.0|
Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + M + + + + + + + | 59 |
Hematopoietic Cell Proliferation | 4 | 7 3.4|
__________________________________________________________________________|____________|
Thymus | + + A + + + + + M + | 48 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization, Focal | 2 | 1 2.0|
Mineralization | 2 3 3 3 | 25 2.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Alveolar Epithelium, Metaplasia | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| | |
| 9| 0| 0| 0| 1| 0| 0| 0| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | 2 2 | 6 2.0|
Inflammation, Chronic | 2 2 2 2 | 42 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + | 59 |
Cyst | X | 4 1.0|
Mineralization, Focal | | 1 1.0|
Mineralization | 1 1 1 2 1 1 | 28 1.3|
Nephropathy | | 1 1.0|
Cortex, Cyst | | 1 |
Renal Tubule, Mineralization | | 1 1.0|
Renal Tubule, Regeneration | 1 1 2 1 1 | 33 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + | 58 |
Inflammation, Chronic, Focal | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 5| 5| 3| 3| 2| 2| 2| 2|
| 1| 0| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 7| 9| 0| 0| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 4 3 3 3 3 2 2 3 3 3 4 3 3 2 4|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + M M + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X |
Clear Cell Focus | X X X X X X |
Clear Cell Focus, Multiple | |
Eosinophilic Focus | X X X|
Fatty Change | 1 2 2 1 |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Mixed Cell Focus | X |
Necrosis, Focal | |
__________________________________________________________________________|
Mesentery | |
Fibrosis | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Tongue | |
Hemorrhage, Focal | |
__________________________________________________________________________|
Tooth | +|
Hypertrophy | 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Hyperplasia, Focal | 1 1 2 3 3 1 2 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 5| 5| 3| 3| 2| 2| 2| 2|
| 1| 0| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 7| 9| 0| 0| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 3 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 3 2 3 1 2 2 4 1 3 4 4 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M M + + + M + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Cyst | X|
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + M + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X|
Cyst, Two | |
Ectasia | 3 3 4 4 4 4 3 3 3 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Prostate | M + + + + + + + + + + + + + + + + + + + M + + + +|
Dilatation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4 4 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + M + M + + + + + + + +|
Lymphatic, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 3 |
Infiltration Cellular, Histiocyte | |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 5| 5| 3| 3| 2| 2| 2| 2|
| 1| 0| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 7| 9| 0| 0| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | 3 3 1 1 |
Hematopoietic Cell Proliferation | 3 3 1 3 |
__________________________________________________________________________|
Thymus | M M + + + + + + + + + + + + + + M + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
Mineralization | 2 1 3 3 3 3 3 2 2 1 2 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 3 |
Alveolar Epithelium, Metaplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 |
Casts | X |
Cyst | |
Inflammation, Chronic, Focal | |
Mineralization, Focal | 1 |
Mineralization | 2 1 2 2 2 1 2 2 2 2 3 3 2 2 2 1 |
Renal Tubule, Cyst | |
Renal Tubule, Degeneration | |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Regeneration | 2 1 2 2 2 2 2 2 2 1 1 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 4| 7| 7| 5| 7| 4| 7| 4| 7| 7| 7| 4| 7| 7| 7| 4| 4| 4| 7|
DAY ON TEST | 3| 5| 3| 2| 2| 2| 5| 2| 2| 7| 2| 5| 2| 5| 2| 2| 2| 5| 2| 2| 2| 5| 5| 5| 2|
| 0| 9| 0| 9| 9| 9| 9| 9| 9| 8| 9| 7| 9| 7| 9| 9| 9| 9| 9| 9| 9| 7| 7| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M M + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 4 3 3 2 4 3 3 3 3 4 2|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | M + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + M + M + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | |
Clear Cell Focus | X X X X|
Clear Cell Focus, Multiple | X |
Eosinophilic Focus | X X X X |
Fatty Change | 1 2 2 2 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 |
Mixed Cell Focus | |
Necrosis, Focal | 4 |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | 2 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | |
__________________________________________________________________________|
Tongue | |
Hemorrhage, Focal | |
__________________________________________________________________________|
Tooth | |
Hypertrophy | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Hyperplasia, Focal | 2 2 3 1 2 2 2|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 4| 7| 7| 5| 7| 4| 7| 4| 7| 7| 7| 4| 7| 7| 7| 4| 4| 4| 7|
DAY ON TEST | 3| 5| 3| 2| 2| 2| 5| 2| 2| 7| 2| 5| 2| 5| 2| 2| 2| 5| 2| 2| 2| 5| 5| 5| 2|
| 0| 9| 0| 9| 9| 9| 9| 9| 9| 8| 9| 7| 9| 7| 9| 9| 9| 9| 9| 9| 9| 7| 7| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M M + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 1 2 3 2 2 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + M I + + + M + + + M + + M M + M + M I + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + I +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + M + M + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X X |
Cyst, Two | X |
Ectasia | 3 4 4 3 4 3|
Inflammation, Acute, Focal | 1 |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 4 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M M + + + M + I + + + I + + + M M + +|
Lymphatic, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + M + + + + + + + + + + + + + + +|
Congestion | 1 |
Depletion Lymphoid | |
Infiltration Cellular, Histiocyte | 4 |
Lymphatic, Angiectasis | 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 4| 7| 7| 5| 7| 4| 7| 4| 7| 7| 7| 4| 7| 7| 7| 4| 4| 4| 7|
DAY ON TEST | 3| 5| 3| 2| 2| 2| 5| 2| 2| 7| 2| 5| 2| 5| 2| 2| 2| 5| 2| 2| 2| 5| 5| 5| 2|
| 0| 9| 0| 9| 9| 9| 9| 9| 9| 8| 9| 7| 9| 7| 9| 9| 9| 9| 9| 9| 9| 7| 7| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | 1 1 1 |
Hematopoietic Cell Proliferation | 3 2 4 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 2 2 1 2 2 |
Mineralization | 1 3 3 2 3 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
Alveolar Epithelium, Metaplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 1 2 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3|
Metaplasia, Squamous | 3|
__________________________________________________________________________|
Trachea | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 |
Casts | |
Cyst | X |
Inflammation, Chronic, Focal | 2 |
Mineralization, Focal | |
Mineralization | 1 2 2 2 1 1 1 |
Renal Tubule, Cyst | |
Renal Tubule, Degeneration | 3 |
Renal Tubule, Dilatation | |
Renal Tubule, Regeneration | 2 1 2 2 1 3 1 2 1 3 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 7| 2| 2| 4| 2| 2| 2| | |
| 9| 9| 9| 5| 9| 9| 1| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + M + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + | 59 |
Hyperplasia, Lymphoid | 2 3 4 3 4 | 34 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 3 | 3 2.7|
Basophilic Focus | | 1 |
Clear Cell Focus | X X X | 13 |
Clear Cell Focus, Multiple | | 1 |
Eosinophilic Focus | X X | 9 |
Fatty Change | | 9 1.7|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis, Focal | 4 | 2 4.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fibrosis | | 1 2.0|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | 4 | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Hemorrhage, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Hypertrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 7| 2| 2| 4| 2| 2| 2| | |
| 9| 9| 9| 5| 9| 9| 1| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Hyperplasia, Focal | 4 2 2 | 17 2.1|
Hyperplasia | 4 | 2 3.5|
Hypertrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 2 4 2 2 2 | 29 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + M + + | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 57 |
Follicular Cell, Hyperplasia, Focal | | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
Fibrosis, Focal | | 1 2.0|
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 41 |
Cyst | X X X X | 23 |
Cyst, Two | | 1 |
Ectasia | 4 4 3 4 4 4 | 21 3.6|
Inflammation, Acute, Focal | | 1 1.0|
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + M + + + + + + | 57 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | 4 4 | 11 3.8|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 7| 2| 2| 4| 2| 2| 2| | |
| 9| 9| 9| 5| 9| 9| 1| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 50 |
Lymphatic, Angiectasis | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Congestion | | 1 1.0|
Depletion Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 4.0|
Lymphatic, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Depletion Lymphoid | 1 | 8 1.5|
Hematopoietic Cell Proliferation | 2 | 11 2.5|
__________________________________________________________________________|____________|
Thymus | + + + M + + M I + + | 51 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization, Focal | | 7 1.7|
Mineralization | 3 3 2 3 2 2 | 25 2.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Pigmentation | | 1 3.0|
Alveolar Epithelium, Metaplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 4 1.8|
Inflammation, Chronic | 2 2 2 2 1 2 2 2 2 | 43 2.0|
Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 7| 2| 2| 4| 2| 2| 2| | |
| 9| 9| 9| 5| 9| 9| 1| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Atrophy, Focal | | 4 2.0|
Casts | | 1 |
Cyst | | 1 |
Inflammation, Chronic, Focal | | 1 2.0|
Mineralization, Focal | | 1 1.0|
Mineralization | 2 2 1 2 2 1 1 2 2 2 | 33 1.8|
Renal Tubule, Cyst | X | 1 |
Renal Tubule, Degeneration | | 1 3.0|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Regeneration | 1 2 2 1 2 | 33 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 6| 7| 5| 6| 7| 7| 4| 6| 4| 4| 7|
DAY ON TEST | 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 5| 2| 6| 2| 8| 2| 2| 2| 5| 6| 5| 5| 2|
| 9| 2| 9| 9| 9| 8| 8| 8| 8| 8| 8| 9| 7| 8| 6| 8| 8| 9| 8| 8| 9| 9| 7| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
1250 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + M M + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
Degeneration, Hyaline | 2 |
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 4 2 3 4 4 3 3 2 2 4 2 3|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + A + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X X |
Congestion | 2 |
Eosinophilic Focus | X |
Fatty Change | 2 2 2 3 2 3 |
Infarct | 4 |
Necrosis, Focal | 3 |
Artery, Fibrosis | 2 |
Artery, Thrombosis | X |
Bile Duct, Hyperplasia | 4 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation, Granulomatous | 4 |
Necrosis, Focal | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 4 2|
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | |
Inflammation, Granulomatous | 2 |
Necrosis, Focal | 3 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 6| 7| 5| 6| 7| 7| 4| 6| 4| 4| 7|
DAY ON TEST | 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 5| 2| 6| 2| 8| 2| 2| 2| 5| 6| 5| 5| 2|
| 9| 2| 9| 9| 9| 8| 8| 8| 8| 8| 8| 9| 7| 8| 6| 8| 8| 9| 8| 8| 9| 9| 7| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
1250 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Congestion | 2 |
Hyperplasia, Focal | 2 3 3 4 |
Hyperplasia | |
Hypertrophy, Focal | 2 3 |
Capsule, Hyperplasia | 4 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + M + + I +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + M + + +|
Atrophy | |
Hyperplasia | 4 4 3 2 3 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + I + + + + + M + + + + + + + + + I +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + I I + + +|
Congestion | 2 |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Cyst | X X X X X X X |
Cyst, Two | |
Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | |
Dilatation | 4 4 4 4 4 |
Inflammation, Chronic, Focal | |
Inflammation, Granulomatous | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 6| 7| 5| 6| 7| 7| 4| 6| 4| 4| 7|
DAY ON TEST | 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 5| 2| 6| 2| 8| 2| 2| 2| 5| 6| 5| 5| 2|
| 9| 2| 9| 9| 9| 8| 8| 8| 8| 8| 8| 9| 7| 8| 6| 8| 8| 9| 8| 8| 9| 9| 7| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
1250 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | 2 2 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + M + + + + + + M + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +|
Congestion | |
Inflammation, Granulomatous | 4 |
Necrosis, Focal | 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 2 3 |
Developmental Malformation | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 4 3 4 3 3 |
Necrosis, Focal | 2 2 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + M + + + + + + + + + M I +|
Depletion Lymphoid | 3 |
Necrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperkeratosis | 2 |
Inflammation, Granulomatous | 4 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 2 |
Mineralization | 2 2 2 3 2 3 3 2 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Inflammation, Granulomatous | 4 |
Alveolar Epithelium, Metaplasia | 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 2 |
Inflammation, Chronic | 2 2 2 2 1 2 2 2 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 6| 7| 5| 6| 7| 7| 4| 6| 4| 4| 7|
DAY ON TEST | 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 5| 2| 6| 2| 8| 2| 2| 2| 5| 6| 5| 5| 2|
| 9| 2| 9| 9| 9| 8| 8| 8| 8| 8| 8| 9| 7| 8| 6| 8| 8| 9| 8| 8| 9| 9| 7| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
1250 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 2 |
Autolysis | 3 |
Congestion | 2 |
Crystals | |
Cyst | X X |
Glomerulosclerosis | 4 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 2 |
Mineralization, Focal | 1 |
Mineralization | 1 1 1 2 2 2 2 2 1 2 2 2 2 2|
Nephropathy | 2 |
Renal Tubule, Degeneration | 4 |
Renal Tubule, Dilatation | |
Renal Tubule, Regeneration | 2 2 1 2 2 2 1 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + A + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 2| 2| 9| 5| 2| 5| 2| 2| 2| 5| 2| 2| 5| 5| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|
| 9| 8| 8| 5| 7| 8| 9| 8| 5| 8| 7| 8| 8| 9| 7| 0| 8| 8| 8| 8| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
1250 PPM | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + A + + + + + + M + +|
Degeneration, Hyaline | |
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 4 3 4 2 4 3 3 3 4 3 3 3 2|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + A + + + + + + + + +|
Clear Cell Focus | X |
Congestion | |
Eosinophilic Focus | |
Fatty Change | 1 2 2 2 2 2 |
Infarct | |
Necrosis, Focal | 2 2 |
Artery, Fibrosis | |
Artery, Thrombosis | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +|
Congestion | |
Inflammation, Granulomatous | |
Necrosis, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + + + +|
Acanthosis | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + A + +|
Diverticulum | 3 |
Inflammation, Chronic, Focal | |
Inflammation, Chronic | 2 |
Inflammation, Granulomatous | |
Necrosis, Focal | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 2| 2| 9| 5| 2| 5| 2| 2| 2| 5| 2| 2| 5| 5| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|
| 9| 8| 8| 5| 7| 8| 9| 8| 5| 8| 7| 8| 8| 9| 7| 0| 8| 8| 8| 8| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
1250 PPM | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + M + + + + + + + + A + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Congestion | |
Hyperplasia, Focal | 2 3 2 1|
Hyperplasia | 4 |
Hypertrophy, Focal | 4 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + M + + + + + + + + A + + + + + + + M +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 4 4 3 2 3 3 1 1 2 3 4 |
__________________________________________________________________________|
Parathyroid Gland | M M M + M + M + + + M M + + + M M + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + I + + + + + +|
Congestion | |
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + M + +|
Cyst | X X X X X X X X|
Cyst, Two | X |
Ectasia | 3 4 3 3 4 4 4 3 3 4|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Chronic, Focal | 1 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Congestion | 1 |
Dilatation | 4 3 4 4 |
Inflammation, Chronic, Focal | 1 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | M + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 2| 2| 9| 5| 2| 5| 2| 2| 2| 5| 2| 2| 5| 5| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|
| 9| 8| 8| 5| 7| 8| 9| 8| 5| 8| 7| 8| 8| 9| 7| 0| 8| 8| 8| 8| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
1250 PPM | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + I + + + + + M + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + A + + + + + + + + +|
Congestion | 1 |
Inflammation, Granulomatous | |
Necrosis, Focal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + M + + + + + + + + +|
Congestion | 3 3 3 3 |
Depletion Lymphoid | 2 |
Developmental Malformation | X |
Fibrosis | |
Hematopoietic Cell Proliferation | 4 2 1 4 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + I + M + + + + M + + + +|
Depletion Lymphoid | 2 |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperkeratosis | |
Inflammation, Granulomatous | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + M + + + + + + + + + +|
Mineralization, Focal | 2 2 1 2 |
Mineralization | 2 2 2 3 3 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 4 |
Inflammation, Granulomatous | |
Alveolar Epithelium, Metaplasia | |
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 2 2 1 |
Inflammation, Chronic | 2 1 3 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 2| 2| 9| 5| 2| 5| 2| 2| 2| 5| 2| 2| 5| 5| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|
| 9| 8| 8| 5| 7| 8| 9| 8| 5| 8| 7| 8| 8| 9| 7| 0| 8| 8| 8| 8| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
1250 PPM | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +|
Atrophy, Focal | 3 |
Autolysis | |
Congestion | |
Crystals | 1 |
Cyst | X X |
Glomerulosclerosis | |
Inflammation, Acute, Focal | 3 |
Inflammation, Chronic, Focal | 1 |
Mineralization, Focal | 1 1 1 |
Mineralization | 2 2 2 1 1 2 2 1 2 2 2 2 2|
Nephropathy | 3 |
Renal Tubule, Degeneration | |
Renal Tubule, Dilatation | 1 1 |
Renal Tubule, Regeneration | 1 2 1 2 1 2 2 2 1 2 1 2 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + A + +|
Inflammation, Chronic, Focal | 2 |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 1| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 3| 8| 5| 5| 5| 5| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
1250 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + | 56 |
Degeneration, Hyaline | | 1 2.0|
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | 4 3 3 3 3 3 3 2 3 | 39 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 58 |
Clear Cell Focus | X | 5 |
Congestion | | 1 2.0|
Eosinophilic Focus | X X | 3 |
Fatty Change | 2 | 13 2.1|
Infarct | | 1 4.0|
Necrosis, Focal | | 3 2.3|
Artery, Fibrosis | | 1 2.0|
Artery, Thrombosis | | 1 |
Bile Duct, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 58 |
Congestion | | 1 2.0|
Inflammation, Granulomatous | | 1 4.0|
Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 59 |
Inflammation, Chronic, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 58 |
Acanthosis | | 3 2.7|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 57 |
Diverticulum | | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Granulomatous | | 1 2.0|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 1| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 3| 8| 5| 5| 5| 5| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
1250 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + | 57 |
Accessory Adrenal Cortical Nodule | | 1 |
Congestion | | 1 2.0|
Hyperplasia, Focal | 4 2 3 2 2 2 | 14 2.5|
Hyperplasia | 3 | 2 3.5|
Hypertrophy, Focal | | 3 3.0|
Capsule, Hyperplasia | | 2 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 56 |
Atrophy | | 1 3.0|
Hyperplasia | 3 3 2 4 2 1 | 25 2.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + + + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 54 |
Congestion | | 1 2.0|
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 30 |
Cyst | X X X X X X X | 22 |
Cyst, Two | | 1 |
Ectasia | 4 3 | 12 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 57 |
Inflammation, Chronic, Focal | | 2 1.5|
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 59 |
Atrophy | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 1| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 3| 8| 5| 5| 5| 5| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
1250 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Congestion | | 1 1.0|
Dilatation | 4 | 10 3.9|
Inflammation, Chronic, Focal | | 1 1.0|
Inflammation, Granulomatous | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 59 |
Interstitial Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + | 27 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 57 |
Hyperplasia, Neutrophil | | 2 2.0|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + | 51 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 56 |
Congestion | | 1 1.0|
Inflammation, Granulomatous | | 1 4.0|
Necrosis, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 58 |
Congestion | | 4 3.0|
Depletion Lymphoid | 1 | 4 2.0|
Developmental Malformation | | 1 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 4 3 | 11 3.2|
Necrosis, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + | 51 |
Depletion Lymphoid | | 2 2.5|
Necrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 59 |
Congestion | | 1 2.0|
Hyperkeratosis | | 1 2.0|
Inflammation, Granulomatous | | 1 4.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 1| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 3| 8| 5| 5| 5| 5| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
1250 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 58 |
Mineralization, Focal | | 7 1.9|
Mineralization | 1 3 2 2 | 22 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 59 |
Congestion | | 1 2.0|
Hemorrhage | | 1 4.0|
Inflammation, Granulomatous | | 1 4.0|
Alveolar Epithelium, Metaplasia | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 58 |
Inflammation, Chronic, Focal | | 10 1.9|
Inflammation, Chronic | 2 2 2 2 2 2 2 | 31 1.9|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 58 |
Atrophy, Focal | 2 | 4 2.5|
Autolysis | | 1 3.0|
Congestion | | 1 2.0|
Crystals | | 1 1.0|
Cyst | | 4 |
Glomerulosclerosis | | 1 4.0|
Inflammation, Acute, Focal | | 1 3.0|
Inflammation, Chronic, Focal | | 2 1.5|
Mineralization, Focal | | 4 1.0|
Mineralization | 2 1 2 1 1 | 32 1.7|
Nephropathy | | 2 2.5|
Renal Tubule, Degeneration | | 1 4.0|
Renal Tubule, Dilatation | | 2 1.0|
Renal Tubule, Regeneration | 2 1 1 1 2 2 | 37 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 1| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 3| 8| 5| 5| 5| 5| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
1250 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 7| 6| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 5| 8| 6| 2| 2| 2| 6| 2| 2| 2| 2| 2| 9| 2| 2| 9| 2| 2|
| 5| 7| 9| 5| 5| 0| 5| 9| 3| 7| 7| 5| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
2500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + A + + + M + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + A + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + M + +|
Parasite Metazoan | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 2 3 4|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + A M + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + M A + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X |
Eosinophilic Focus | X X X |
Fatty Change | 2 2 |
Hemorrhage | 2 |
Necrosis, Focal | 2 |
Nuclear Alteration | 3 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Granulomatous | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +|
Acanthosis | 3 |
Hyperplasia, Squamous | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + A + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Dilatation | 4 |
Valve, Pigmentation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + M + + + + + + + + M + + + + + + + + + + + + +|
Atrophy | |
Congestion | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 7| 6| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 5| 8| 6| 2| 2| 2| 6| 2| 2| 2| 2| 2| 9| 2| 2| 9| 2| 2|
| 5| 7| 9| 5| 5| 0| 5| 9| 3| 7| 7| 5| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
2500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | |
Hyperplasia, Focal | |
Hyperplasia | 3 3 3 |
Hypertrophy, Focal | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + M + + + + + + + + + + + + +|
Hemorrhage | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 4 2 2 2 |
Hypoplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + I M + M + M I + + + + M + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + M + +|
Congestion | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + |
Cyst | X X X X X X X X X |
Cyst, Two | X X X |
Ectasia | 4 4 3 4 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | |
Hemorrhage, Focal | |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 3 |
Fibrosis | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + +|
Neutrophilia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + M|
Hyperplasia, Neutrophil | 3 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M M + M + M + + + M + + + M + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + M M + + M + + M + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 7| 6| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 5| 8| 6| 2| 2| 2| 6| 2| 2| 2| 2| 2| 9| 2| 2| 9| 2| 2|
| 5| 7| 9| 5| 5| 0| 5| 9| 3| 7| 7| 5| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
2500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 3 2 |
Depletion Lymphoid | 3 3 2 |
Inflammation, Granulomatous | |
Necrosis, Focal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | 2 3 3 3 3 |
Hematopoietic Cell Proliferation | 4 4 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + M + + M + M + + + M + + I + +|
Depletion Lymphoid | 3 3 3 |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic Active | |
Pigmentation | |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 1 |
Mineralization | 3 3 1 2 2 1 2 3 3 3 3 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Granulomatous | |
Alveolar Epithelium, Metaplasia | 3 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 2 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | A |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 7| 6| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 5| 8| 6| 2| 2| 2| 6| 2| 2| 2| 2| 2| 9| 2| 2| 9| 2| 2|
| 5| 7| 9| 5| 5| 0| 5| 9| 3| 7| 7| 5| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
2500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Crystals | 3 2 2 2 2 2 2 2 2 1|
Cyst | X X |
Inflammation, Chronic | |
Mineralization, Focal | |
Mineralization | 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 2 2 1 |
Nephropathy | 4 4 3 4 4 4 3 3 4 4|
Renal Tubule, Regeneration | 1 1 1 2 2 1 1 1 1 2 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + A + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 4| 7| 7| 4| 0| 4| 7| 7| 4| 6| 7| 7| 6| 2|
DAY ON TEST | 5| 2| 5| 5| 2| 2| 2| 5| 0| 2| 2| 5| 2| 2| 5| 2| 5| 2| 2| 5| 7| 2| 2| 0| 6|
| 9| 5| 7| 9| 5| 5| 5| 9| 5| 5| 5| 7| 5| 5| 7| 3| 9| 5| 5| 9| 5| 5| 5| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
2500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + M + + + + + + + + + M + + + M A + + + A|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | 3 3 3 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Eosinophilic Focus | |
Fatty Change | 2 2 2 1 2 3 1 2 |
Hemorrhage | 1 |
Necrosis, Focal | |
Nuclear Alteration | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Granulomatous | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperplasia, Squamous | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Dilatation | |
Valve, Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Congestion | 1|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 4| 7| 7| 4| 0| 4| 7| 7| 4| 6| 7| 7| 6| 2|
DAY ON TEST | 5| 2| 5| 5| 2| 2| 2| 5| 0| 2| 2| 5| 2| 2| 5| 2| 5| 2| 2| 5| 7| 2| 2| 0| 6|
| 9| 5| 7| 9| 5| 5| 5| 9| 5| 5| 5| 7| 5| 5| 7| 3| 9| 5| 5| 9| 5| 5| 5| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
2500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | |
Hyperplasia, Focal | 2 3 3 2 1 |
Hyperplasia | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 2 1 4 2 1 2 2 |
Hypoplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M M M + + + + M + + + + + M + + + + M + M + + +|
__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + + + + + + M + + + + + + + M +|
Congestion | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + |
Cyst | X X X X X X X X |
Cyst, Two | X X X |
Ectasia | 4 4 4 3 3 4 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage, Focal | 2 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Fibrosis | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M I + + + + M + M M + M + + + + + + M + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + M + + + M|
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 4| 7| 7| 4| 0| 4| 7| 7| 4| 6| 7| 7| 6| 2|
DAY ON TEST | 5| 2| 5| 5| 2| 2| 2| 5| 0| 2| 2| 5| 2| 2| 5| 2| 5| 2| 2| 5| 7| 2| 2| 0| 6|
| 9| 5| 7| 9| 5| 5| 5| 9| 5| 5| 5| 7| 5| 5| 7| 3| 9| 5| 5| 9| 5| 5| 5| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
2500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | |
Depletion Lymphoid | 3 |
Inflammation, Granulomatous | |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | 4 2 2|
Hematopoietic Cell Proliferation | 3 2 |
__________________________________________________________________________|
Thymus | + + + + I + + + M + + + M + + + + M + + M + + + M|
Depletion Lymphoid | 2 |
Necrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + A|
Edema | 3 |
Inflammation, Chronic Active | 3 |
Pigmentation | 2 |
Subcutaneous Tissue, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 1 |
Mineralization | 3 3 3 2 2 1 3 3 2 1 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Granulomatous | |
Alveolar Epithelium, Metaplasia | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 |
Inflammation, Chronic | 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 4| 7| 7| 4| 0| 4| 7| 7| 4| 6| 7| 7| 6| 2|
DAY ON TEST | 5| 2| 5| 5| 2| 2| 2| 5| 0| 2| 2| 5| 2| 2| 5| 2| 5| 2| 2| 5| 7| 2| 2| 0| 6|
| 9| 5| 7| 9| 5| 5| 5| 9| 5| 5| 5| 7| 5| 5| 7| 3| 9| 5| 5| 9| 5| 5| 5| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
2500 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Crystals | 2 2 3 1 1 3 4 |
Cyst | |
Inflammation, Chronic | 4 |
Mineralization, Focal | 1 1 |
Mineralization | 2 1 1 1 1 2 2 2 1 1 2 1 |
Nephropathy | 4 3 4 4 |
Renal Tubule, Regeneration | 1 1 2 1 1 2 1 2 1 1 2 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 6| 7| 6| 5| 7| 7| 7| | |
DAY ON TEST | 2| 6| 2| 0| 2| 3| 1| 2| 2| 2| | |
| 5| 9| 6| 5| 5| 1| 8| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
2500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + A + + + | 50 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + | 56 |
Parasite Metazoan | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + | 57 |
Parasite Metazoan | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + A + + + | 56 |
Hyperplasia, Lymphoid | | 9 2.9|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + A + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + A + + + | 54 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + A + + + | 54 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | X X | 5 |
Fatty Change | 3 | 11 2.0|
Hemorrhage | | 2 1.5|
Necrosis, Focal | | 1 2.0|
Nuclear Alteration | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Granulomatous | 4 | 1 4.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + M + + + + + + | 58 |
Acanthosis | | 1 3.0|
Hyperplasia, Squamous | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 | 1 2.0|
Dilatation | | 1 4.0|
Valve, Pigmentation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 6| 7| 6| 5| 7| 7| 7| | |
DAY ON TEST | 2| 6| 2| 0| 2| 3| 1| 2| 2| 2| | |
| 5| 9| 6| 5| 5| 1| 8| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
2500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Atrophy | | 1 2.0|
Congestion | | 1 1.0|
Cyst | X | 1 |
Hyperplasia, Focal | | 5 2.2|
Hyperplasia | | 3 3.0|
Hypertrophy, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + I + + + + + | 56 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 4 4 2 2 | 21 2.2|
Hypoplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + + M + | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + M M + + | 52 |
Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + | 58 |
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Granulomatous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 37 |
Cyst | X X X | 20 |
Cyst, Two | X X | 8 |
Ectasia | 4 | 16 3.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Cyst | | 1 |
Hemorrhage, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | | 2 3.5|
Fibrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 6| 7| 6| 5| 7| 7| 7| | |
DAY ON TEST | 2| 6| 2| 0| 2| 3| 1| 2| 2| 2| | |
| 5| 9| 6| 5| 5| 1| 8| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
2500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + | 22 |
Neutrophilia | 4 | 2 4.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Hyperplasia, Neutrophil | 3 4 | 4 3.0|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + M + + + + | 43 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M M + + | 49 |
Congestion | | 2 2.5|
Depletion Lymphoid | | 4 2.8|
Inflammation, Granulomatous | 3 | 1 3.0|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | 4 | 1 4.0|
Depletion Lymphoid | 2 2 | 10 2.6|
Hematopoietic Cell Proliferation | 3 4 | 6 3.3|
__________________________________________________________________________|____________|
Thymus | + + M + + M M + + + | 45 |
Depletion Lymphoid | 3 | 5 2.8|
Necrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Edema | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
Pigmentation | | 1 2.0|
Subcutaneous Tissue, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization, Focal | | 4 1.0|
Mineralization | 1 2 3 2 3 3 2 | 35 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05127-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 6| 7| 6| 5| 7| 7| 7| | |
DAY ON TEST | 2| 6| 2| 0| 2| 3| 1| 2| 2| 2| | |
| 5| 9| 6| 5| 5| 1| 8| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
2500 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
Alveolar Epithelium, Metaplasia | | 4 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Acute, Focal | | 1 1.0|
Inflammation, Chronic, Focal | | 9 2.0|
Inflammation, Chronic | 2 2 2 2 2 2 2 | 42 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Crystals | 3 2 3 4 1 | 22 2.2|
Cyst | | 2 |
Inflammation, Chronic | | 1 4.0|
Mineralization, Focal | | 2 1.0|
Mineralization | 2 1 2 1 1 2 | 36 1.3|
Nephropathy | 4 2 4 3 3 | 19 3.6|
Renal Tubule, Regeneration | 2 1 1 | 30 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + A + + + | 55 |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
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---------- END OF REPORT ----------
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