TDMS Study 05127-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/16/94
EXP: 05127 BARIUM CHLORIDE DIHYDRATE TIME: 22:02:33
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP C#: C61074
CONT: N01ES55115 CAS: 10326279
PATHOLOGIST: A. RUSSFIELD S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/16/94
EXP: 05127 BARIUM CHLORIDE DIHYDRATE TIME: 22:02:33
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP C#: C61074
CONT: N01ES55115 CAS: 10326279
PATHOLOGIST: A. RUSSFIELD S. EUSTIS
BARIUM CHLORIDE DIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 725 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 6 CENSORED DEATHS 9 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 303 406 492 596 693 717 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 520 529 578 602 641 661 675 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 403 442 457 588 613 629 666 669 695 720 |
| CENSORED DEATHS |
| 457 457 457 457 459 459 459 459 459 459 |
| |
==================================================================================
BARIUM CHLORIDE DIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 725 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 23 261 399 469 483 494 518 567 602 605 |
| 605 626 627 631 659 664 675 720 |
| CENSORED DEATHS |
| 457 457 457 457 459 459 459 459 459 459 |
| |
==================================================================================
BARIUM CHLORIDE DIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 725 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 725 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 98.3 96.7 96.7 94.7 92.7 92.7 88.8 |
| | |
| | |
|500 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 88.0 86.0 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 100.0 98.3 94.9 94.9 92.9 88.7 80.5 |
| | |
| | |
|2500 PPM | 98.3 98.3 96.7 96.7 95.0 91.0 86.9 78.8 68.7 64.7 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 500 PPM 1250 PPM 2500 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 88.8% 86.0% 80.5% 64.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.001 P=0.977 P=0.378 P=0.009 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 534.5 600.9 588.2 534.9 |
|NATURAL DEATHS (C) | (66.9) (23.4) (36.0) (40.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 665.9 666.0 656.6 623.5 |
|(STANDARD ERROR) | (14.9) (13.4) (14.7) (18.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BARIUM CHLORIDE DIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 12 CENSORED DEATHS 10 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 478 498 541 561 573 580 602 605 665 675 |
| 692 722 |
| CENSORED DEATHS |
| 462 462 462 462 462 462 464 464 464 464 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 7 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 373 377 380 455 462 467 535 561 564 607 |
| 616 645 655 703 719 721 |
| CENSORED DEATHS |
| 464 464 464 464 464 464 464 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 14 CENSORED DEATHS 10 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 360 429 605 609 616 627 645 680 685 707 |
| 714 720 721 723 |
| CENSORED DEATHS |
| 462 462 462 462 462 462 464 464 464 464 |
| |
==================================================================================
BARIUM CHLORIDE DIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 41 CENSORED DEATHS 6 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 104 106 108 112 135 135 142 142 150 157 |
| 171 173 177 203 213 221 225 230 234 248 |
| 248 298 317 395 412 436 561 585 617 643 |
| 643 658 658 666 673 674 679 707 718 720 |
| 723 |
| CENSORED DEATHS |
| 462 462 462 464 464 464 |
| |
==================================================================================
BARIUM CHLORIDE DIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 84.0 82.0 76.0 |
| | |
| | |
|500 PPM | 100.0 100.0 100.0 100.0 95.0 89.8 87.8 84.0 76.4 70.7 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 98.3 98.3 96.7 96.7 94.7 86.6 72.5 |
| | |
| | |
|2500 PPM | 100.0 78.3 65.0 61.7 58.3 56.7 56.7 52.6 42.5 26.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 500 PPM 1250 PPM 2500 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.0% 70.7% 72.5% 26.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.535 P=0.911 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 599.3 552.5 631.5 376.0 |
|NATURAL DEATHS (C) | (22.1) (30.5) (29.5) (36.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 662.5 654.7 665.5 462.5 |
|(STANDARD ERROR) | (14.2) (15.8) (14.6) (31.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BARIUM CHLORIDE DIHYDRATE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
500 PPM = 2
1250 PPM = 3
2500 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 3 2
| 4 4 1 1 3
| 22
| 4 41 3 3 1 2 2
95 + 4 34 1 3 1
| 2 2
P | 4 4 3 1 3 2 1
E | 4 4 3 3 1 1
R 90 + 2 2
C | 4 4 3 3 11
E | 4 4 2 2
N | 2 2
T 85 + 4 4 3 3
|
S | 44 3 3
U |
R 80 + 33
V | 4 4
I |
V |
A 75 + 44
L |
| 4 4
|
70 +
| 4 4
|
| 4 4
65 + 44
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
BARIUM CHLORIDE DIHYDRATE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
500 PPM = 2
1250 PPM = 3
2500 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 2 1
| 44 3 2 2 3 1 1 3
| 2 2 1 1 1
| 4 4 222 11 33
90 + 44 2 2 11 3 3
| 44 2 2 1 1 3 3 3
| 44 2 11 1
| 4 4 22 1 13 3
P 80 + 44 2 2 1 1 33
E | 4 4 4 22 1 2331
R | 44 2 21 1
C | 44 3 3
E 70 + 44 2 2
N | 4 4
T | 4 4
| 4 4 4
S 60 + 4 4
U | 4 4 4
R | 4 4
V | 4 4
I 50 + 4 4
V | 4 4
A |
L | 4 4
40 + 44
|
| 4 4
| 4 4
30 +
| 44 4
|
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.