TDMS Study 05127-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
BARIUM CHLORIDE DIHYDRATE
NTP Experiment-Test: 05127-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
Facility: TSI Mason Research
Chemical CAS #: 10326279
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 14 11 9 16
Dead 5 3 2 2
Survivors
Terminal Sacrifice 30 36 39 32
Moribund 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (57) (58) (59) (60)
Edema 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%) 4 (7%) 3 (5%)
Muscularis, Hypertrophy 1 (2%) 1 (2%)
Intestine Large, Colon (57) (57) (60) (59)
Parasite Metazoan 5 (9%) 3 (5%) 8 (13%) 5 (8%)
Intestine Large, Rectum (57) (57) (60) (59)
Parasite Metazoan 8 (14%) 13 (23%) 11 (18%) 8 (14%)
Intestine Small, Duodenum (57) (58) (60) (60)
Parasite Metazoan 1 (2%)
Artery, Inflammation, Acute 1 (2%)
Intestine Small, Ileum (57) (57) (59) (60)
Autolysis 1 (2%)
Intestine Small, Jejunum (56) (57) (59) (60)
Parasite Metazoan 1 (2%)
Liver (60) (60) (60) (60)
Angiectasis 1 (2%) 2 (3%) 2 (3%)
Basophilic Focus 39 (65%) 43 (72%) 41 (68%) 40 (67%)
Clear Cell Focus 6 (10%) 4 (7%) 8 (13%) 11 (18%)
Congestion 1 (2%) 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%)
Developmental Malformation 2 (3%) 5 (8%) 5 (8%) 2 (3%)
Fatty Change 13 (22%) 10 (17%) 8 (13%) 10 (17%)
Granuloma 17 (28%) 21 (35%) 17 (28%) 14 (23%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hemorrhage, Focal 1 (2%)
Hepatodiaphragmatic Nodule 7 (12%) 3 (5%) 3 (5%) 6 (10%)
Hepatodiaphragmatic Nodule, Two 2 (3%)
Inflammation, Acute, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic, Focal 1 (2%)
Necrosis, Focal 1 (2%)
Bile Duct, Hyperplasia 6 (10%) 7 (12%) 9 (15%) 9 (15%)
Hepatocyte, Hyperplasia, Focal 5 (8%) 1 (2%)
Perivascular, Inflammation, Chronic 3 (5%) 5 (8%)
Serosa, Fibrosis 1 (2%)
Mesentery (4) (1) (3)
Accessory Spleen 1 (33%)
Artery, Inflammation, Chronic 1 (33%)
Fat, Necrosis 4 (100%) 1 (33%)
Pancreas (59) (57) (59) (60)
Autolysis 1 (2%)
Necrosis 1 (2%)
Acinus, Atrophy 10 (17%) 6 (11%) 9 (15%) 14 (23%)
Acinus, Atrophy, Focal 2 (3%) 1 (2%) 2 (3%) 2 (3%)
Artery, Inflammation, Acute 1 (2%)
Pharynx (1) (1)
Hyperplasia, Basal Cell 1 (100%)
Stomach, Forestomach (60) (60) (60) (60)
Acanthosis 2 (3%)
Bulla 1 (2%)
Edema 1 (2%)
Erosion 1 (2%)
Fibrosis 1 (2%)
Hyperkeratosis 2 (3%)
Hyperplasia, Basal Cell 1 (2%)
Ulcer 2 (3%) 1 (2%)
Stomach, Glandular (59) (60) (60) (60)
Cyst Epithelial Inclusion 1 (2%)
Erosion 1 (2%)
Inflammation, Chronic 2 (3%) 1 (2%)
Inflammation, Chronic, Focal 2 (3%)
Mineralization 1 (2%)
Ulcer 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Tooth (1)
Inflammation, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Cardiomyopathy 23 (38%) 28 (47%) 27 (45%) 27 (45%)
Mineralization 2 (3%)
Artery, Inflammation, Chronic 1 (2%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (59) (58) (60)
Congestion 1 (2%) 1 (2%)
Cytoplasmic Alteration 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%) 1 (2%) 4 (7%) 4 (7%)
Hematopoietic Cell Proliferation 1 (2%)
Hypertrophy 1 (2%)
Infarct 1 (2%)
Adrenal Gland, Medulla (60) (59) (58) (59)
Hyperplasia, Focal 6 (10%) 1 (2%) 2 (3%) 1 (2%)
Islets, Pancreatic (59) (58) (59) (59)
Ectopic Tissue 2 (3%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Parathyroid Gland (53) (56) (59) (55)
Hyperplasia 2 (4%)
Pituitary Gland (58) (58) (58) (60)
Pars Distalis, Angiectasis 3 (5%)
Pars Distalis, Cyst 8 (14%) 8 (14%) 4 (7%) 9 (15%)
Pars Distalis, Hyperplasia, Focal 7 (12%) 4 (7%) 4 (7%) 3 (5%)
Thyroid Gland (59) (60) (59) (60)
Ultimobranchial Cyst 1 (2%) 1 (2%)
C-Cell, Hyperplasia 5 (8%) 14 (23%) 5 (8%) 8 (13%)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (60) (59) (60) (57)
Abscess 6 (10%) 2 (3%)
Abscess, Two 1 (2%) 1 (2%)
Cyst 12 (20%) 4 (7%) 3 (5%) 5 (9%)
Cyst, Two 1 (2%) 1 (2%)
Inflammation, Acute 2 (3%) 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Ovary (59) (60) (60) (60)
Congestion 3 (5%) 1 (2%) 1 (2%)
Cyst 3 (5%) 3 (5%) 2 (3%) 5 (8%)
Granuloma 1 (2%)
Uterus (60) (60) (60) (60)
Abscess 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Congestion 1 (2%)
Cyst 2 (3%) 1 (2%) 1 (2%)
Dilatation 3 (5%) 1 (2%)
Hemorrhage 1 (2%)
Prolapse 1 (2%)
Thrombosis 1 (2%)
Endometrium, Cyst 1 (2%) 1 (2%) 3 (5%)
Endometrium, Necrosis 1 (2%)
Vagina (2)
Inflammation, Acute 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (59) (60) (59)
Atrophy 1 (2%)
Hyperplasia 13 (22%) 11 (19%) 9 (15%) 10 (17%)
Lymph Node (60) (60) (60) (60)
Mediastinal, Congestion 2 (3%) 4 (7%) 2 (3%) 6 (10%)
Mediastinal, Pigmentation 1 (2%) 5 (8%)
Mediastinal, Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Pancreatic, Congestion 2 (3%)
Pancreatic, Pigmentation 1 (2%)
Pancreatic, Lymphatic, Angiectasis 1 (2%)
Renal, Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mandibular (59) (58) (58) (59)
Congestion 5 (8%) 6 (10%) 3 (5%) 5 (8%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Lymphatic, Angiectasis 2 (3%) 1 (2%)
Lymph Node, Mesenteric (60) (59) (59) (60)
Autolysis 1 (2%)
Congestion 3 (5%) 6 (10%) 1 (2%) 3 (5%)
Depletion Lymphoid 1 (2%)
Lymphatic, Angiectasis 3 (5%)
Spleen (60) (60) (60) (60)
Congestion, Focal 1 (2%)
Fibrosis 1 (2%) 2 (3%) 1 (2%) 1 (2%)
Granuloma 1 (2%)
Hematopoietic Cell Proliferation 5 (8%) 4 (7%) 1 (2%) 1 (2%)
Hemorrhage, Focal 1 (2%) 1 (2%)
Hyperplasia, Histiocytic, Lymphoid 1 (2%) 3 (5%)
Infarct 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%)
Pigmentation, Hemosiderin 8 (13%) 9 (15%) 10 (17%) 12 (20%)
Capsule, Fibrosis 1 (2%)
Thymus (54) (55) (54) (56)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (52) (52) (55) (59)
Galactocele 7 (13%) 9 (17%) 8 (15%) 5 (8%)
Galactocele, Multiple 2 (4%) 1 (2%)
Lactation 5 (10%) 2 (4%) 4 (7%)
Skin (57) (60) (59) (59)
Hyperkeratosis 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Pigmentation, Melanin 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Hyperostosis 8 (13%) 11 (18%) 10 (17%) 11 (18%)
Skeletal Muscle (1) (2) (1)
Degeneration 1 (50%)
Fibrosis 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 5 (8%) 8 (13%) 4 (7%) 8 (13%)
Hemorrhage, Focal 1 (2%) 1 (2%) 1 (2%)
Hydrocephalus 1 (2%)
Spinal Cord (1) (1)
Hemorrhage, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Congestion 4 (7%) 1 (2%) 1 (2%) 3 (5%)
Hemorrhage, Focal 1 (2%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Metaplasia 1 (2%) 2 (3%) 2 (3%)
Alveolus, Metaplasia 1 (2%)
Bronchus, Metaplasia, Squamous 1 (2%)
Nose (60) (60) (60) (60)
Fungus 3 (5%) 5 (8%) 3 (5%) 2 (3%)
Inflammation, Acute 3 (5%) 5 (8%) 4 (7%) 2 (3%)
Inflammation, Chronic 38 (63%) 41 (68%) 42 (70%) 45 (75%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Chronic, Focal 4 (7%) 7 (12%) 8 (13%) 6 (10%)
Metaplasia, Squamous 2 (3%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (6) (8) (4) (3)
Cataract 1 (17%) 6 (75%) 2 (50%) 1 (33%)
Degeneration 1 (17%)
Hemorrhage 1 (13%)
Synechia 1 (17%)
Cornea, Inflammation, Acute 1 (17%)
Retina, Degeneration 2 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (58) (60) (60)
Autolysis 1 (2%) 2 (3%)
Cyst 1 (2%)
Fibrosis, Focal 2 (3%) 2 (3%)
Hypertrophy 1 (2%)
Mineralization 1 (2%) 3 (5%)
Nephropathy 48 (83%) 48 (83%) 53 (88%) 52 (87%)
Pigmentation, Bile 1 (2%) 1 (2%)
Papilla, Fibrosis, Focal 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Pigmentation 1 (2%)
Urinary Bladder (55) (57) (59) (58)
Hemorrhage, Focal 1 (2%)
Inflammation, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 19 14 18 14
Dead 9 5 3 3
Survivors
Terminal Sacrifice 21 31 29 33
Dead 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (53) (55) (58) (57)
Hemorrhage 1 (2%)
Parasite Metazoan 2 (4%) 1 (2%) 2 (3%) 3 (5%)
Intestine Large, Colon (55) (54) (59) (58)
Parasite Metazoan 5 (9%) 3 (6%) 9 (15%) 12 (21%)
Intestine Large, Rectum (54) (56) (59) (58)
Parasite Metazoan 9 (17%) 6 (11%) 12 (20%) 8 (14%)
Ulcer 1 (2%)
Intestine Small, Ileum (52) (55) (57) (57)
Hyperplasia, Lymphoid 1 (2%)
Liver (59) (60) (60) (60)
Basophilic Focus 3 (5%) 4 (7%) 6 (10%) 4 (7%)
Clear Cell Focus 3 (5%) 9 (15%) 8 (13%) 4 (7%)
Clear Cell Focus, Multiple 1 (2%)
Congestion 1 (2%) 1 (2%) 1 (2%)
Cyst 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%) 1 (2%)
Developmental Malformation 3 (5%) 1 (2%) 1 (2%)
Fatty Change 17 (29%) 14 (23%) 19 (32%) 17 (28%)
Granuloma 3 (5%) 4 (7%) 2 (3%) 3 (5%)
Hemorrhage, Focal 1 (2%)
Hepatodiaphragmatic Nodule 2 (3%) 4 (7%) 3 (5%) 4 (7%)
Hepatodiaphragmatic Nodule, Two 1 (2%)
Necrosis, Focal 1 (2%) 1 (2%) 3 (5%)
Artery, Inflammation, Chronic 1 (2%)
Bile Duct, Hyperplasia 50 (85%) 55 (92%) 54 (90%) 51 (85%)
Hepatocyte, Hyperplasia, Focal 2 (3%) 4 (7%) 6 (10%) 3 (5%)
Lymphatic, Angiectasis 1 (2%)
Serosa, Fibrosis 1 (2%)
Mesentery (5) (6) (10) (4)
Accessory Spleen 1 (20%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hemorrhage 1 (17%)
Mineralization, Focal 1 (17%)
Fat, Necrosis 3 (60%) 5 (83%) 6 (60%) 4 (100%)
Pancreas (55) (58) (59) (60)
Congestion 1 (2%)
Cyst 1 (2%)
Inflammation, Chronic 1 (2%)
Acinus, Atrophy 19 (35%) 16 (28%) 18 (31%) 20 (33%)
Acinus, Atrophy, Focal 4 (7%) 3 (5%) 3 (5%) 2 (3%)
Artery, Fibrosis 1 (2%)
Artery, Inflammation, Chronic 3 (5%)
Pharynx (2)
Hyperplasia, Focal 1 (50%)
Stomach, Forestomach (59) (60) (60) (59)
Acanthosis 1 (2%) 2 (3%) 1 (2%)
Hyperkeratosis 1 (2%)
Hyperkeratosis, Focal 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Ulcer 4 (7%) 2 (3%) 2 (3%)
Stomach, Glandular (57) (58) (60) (58)
Edema 1 (2%)
Inflammation, Chronic, Focal 2 (4%)
Mineralization 1 (2%) 1 (2%)
Tongue (1) (1)
Hyperkeratosis 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Cardiomyopathy 42 (70%) 45 (75%) 44 (73%) 41 (68%)
Dilatation 2 (3%)
Atrium, Dilatation 1 (2%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (59) (60) (59) (60)
Congestion 1 (2%)
Congestion, Focal 1 (2%)
Cytoplasmic Alteration, Focal 3 (5%) 5 (8%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%) 1 (2%)
Adrenal Gland, Medulla (58) (59) (58) (59)
Hyperplasia, Focal 7 (12%) 11 (19%) 5 (9%) 9 (15%)
Hyperplasia, Focal, Two 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Islets, Pancreatic (55) (58) (58) (59)
Hyperplasia 4 (7%) 1 (2%) 2 (3%)
Parathyroid Gland (56) (56) (56) (55)
Hyperplasia 1 (2%)
Pituitary Gland (58) (55) (59) (56)
Infarct 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 1 (2%)
Pars Distalis, Cyst 3 (5%) 5 (9%) 4 (7%) 3 (5%)
Pars Distalis, Degeneration, Focal 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia, Focal 8 (14%) 2 (4%) 9 (15%) 8 (14%)
Thyroid Gland (58) (58) (60) (59)
Cyst 1 (2%)
Cyst Multilocular 1 (2%)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 7 (12%) 4 (7%) 8 (13%) 4 (7%)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (58) (60) (60) (60)
Fibrosis 1 (2%)
Spermatocele 1 (2%)
Preputial Gland (59) (59) (60) (60)
Abscess 2 (3%) 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%) 3 (5%) 1 (2%)
Inflammation, Acute 1 (2%) 2 (3%)
Inflammation, Acute, Focal 2 (3%) 1 (2%) 1 (2%)
Inflammation, Chronic 10 (17%) 11 (19%) 11 (18%) 11 (18%)
Inflammation, Chronic, Focal 1 (2%) 2 (3%) 1 (2%) 1 (2%)
Duct, Ectasia 1 (2%)
Prostate (58) (60) (60) (59)
Abscess 1 (2%)
Atrophy 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 2 (3%) 6 (10%) 4 (7%) 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%) 2 (3%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Seminal Vesicle (59) (59) (59) (60)
Atrophy 26 (44%) 29 (49%) 27 (46%) 26 (43%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Dilatation 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Acute 2 (3%)
Testes (59) (60) (60) (60)
Artery, Inflammation, Chronic 2 (3%)
Bilateral, Interstitial Cell, Hyperplasia 2 (3%) 2 (3%) 4 (7%) 3 (5%)
Bilateral, Seminiferous Tubule, Atrophy,
Focal 1 (2%)
Interstitial Cell, Hyperplasia 2 (3%) 2 (3%) 2 (3%)
Seminiferous Tubule, Atrophy 10 (17%) 9 (15%) 7 (12%) 8 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (55) (59) (60) (59)
Atrophy 1 (2%) 1 (2%)
Hyperplasia 11 (20%) 9 (15%) 14 (23%) 8 (14%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node (59) (57) (60) (60)
Deep Cervical, Lymphatic, Angiectasis 1 (2%)
Mediastinal, Congestion 5 (9%) 6 (10%) 1 (2%)
Mediastinal, Lymphatic, Angiectasis 1 (2%) 1 (2%)
Pancreatic, Congestion 1 (2%) 1 (2%)
Pancreatic, Hemorrhage 1 (2%)
Pancreatic, Lymphatic, Angiectasis 1 (2%)
Lymph Node, Mandibular (59) (55) (59) (60)
Angiectasis 2 (3%)
Congestion 4 (7%) 2 (4%) 3 (5%) 5 (8%)
Infarct 1 (2%)
Infiltration Cellular, Plasma Cell 2 (3%) 2 (4%) 2 (3%)
Pigmentation 1 (2%)
Lymphatic, Angiectasis 2 (3%) 2 (4%) 3 (5%) 1 (2%)
Lymph Node, Mesenteric (57) (57) (60) (59)
Congestion 1 (2%)
Hyperplasia 1 (2%)
Lymphatic, Angiectasis 2 (4%) 3 (5%) 1 (2%) 2 (3%)
Spleen (59) (58) (60) (59)
Congestion 2 (3%) 1 (2%) 3 (5%)
Cyst 1 (2%) 1 (2%)
Developmental Malformation 1 (2%)
Fibrosis 9 (15%) 3 (5%) 8 (13%) 13 (22%)
Hematopoietic Cell Proliferation 2 (3%) 6 (10%)
Infarct 4 (7%) 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 3 (5%)
Capsule, Fibrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymus (54) (54) (53) (53)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (51) (41) (52) (54)
Galactocele 1 (2%) 1 (2%) 1 (2%)
Lactation 2 (4%) 1 (2%) 4 (7%)
Skin (60) (60) (58) (58)
Abscess 1 (2%) 1 (2%)
Acanthosis 1 (2%)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hyperkeratosis 2 (3%) 1 (2%)
Inflammation, Chronic, Granulomatous 1 (2%)
Thrombosis 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Fibrosis 1 (2%)
Hyperostosis 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 2 (3%) 2 (3%) 2 (3%)
Congestion 1 (2%)
Hemorrhage, Focal 5 (8%) 3 (5%) 7 (12%) 3 (5%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Congestion 2 (3%) 3 (5%)
Fungus 1 (2%) 1 (2%)
Hemorrhage, Focal 2 (3%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Adenomatous 1 (2%)
Alveolar Epithelium, Metaplasia 4 (7%) 2 (3%) 2 (3%) 1 (2%)
Nose (60) (58) (60) (60)
Congestion 1 (2%)
Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05127-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 09/16/94
Route: DOSED WATER Time: 18:45:47
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FISCHER 344 RATS MALE 0 PPM 500 PPM 1250 PPM 2500 PPM
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RESPIRATORY SYSTEM - CONT
Fungus 9 (15%) 7 (12%) 7 (12%) 4 (7%)
Inflammation, Acute 12 (20%) 12 (21%) 8 (13%) 7 (12%)
Inflammation, Chronic 37 (62%) 37 (64%) 41 (68%) 41 (68%)
Inflammation, Chronic, Focal 8 (13%) 10 (17%) 9 (15%) 8 (13%)
Metaplasia, Squamous 1 (2%) 1 (2%)
Trachea (59) (58) (60) (59)
Fungus 1 (2%)
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SPECIAL SENSES SYSTEM
Eye (1) (1) (4) (5)
Cataract 1 (100%) 1 (100%) 3 (75%) 3 (60%)
Hemorrhage 1 (20%)
Retina, Degeneration 1 (25%) 3 (60%)
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URINARY SYSTEM
Kidney (57) (57) (59) (59)
Congestion 3 (5%)
Cyst 1 (2%) 2 (3%) 1 (2%)
Fibrosis 1 (2%)
Infarct 2 (3%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Nephropathy 53 (93%) 57 (100%) 57 (97%) 56 (95%)
Pigmentation, Bile 1 (2%) 1 (2%)
Artery, Fibrosis 1 (2%)
Urinary Bladder (52) (55) (57) (58)
Calculus Micro Observation Only 1 (2%)
Cyst 1 (2%)
Ectasia 1 (2%)
Hemorrhage, Focal 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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