TDMS Study 05127-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/16/94
EXP: 05127 BARIUM CHLORIDE DIHYDRATE TIME: 19:15:13
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP C#: C61074
CONT: N01ES55115 CAS: 10326279
PATHOLOGIST: A. RUSSFIELD S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/16/94
EXP: 05127 BARIUM CHLORIDE DIHYDRATE TIME: 19:15:13
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP C#: C61074
CONT: N01ES55115 CAS: 10326279
PATHOLOGIST: A. RUSSFIELD S. EUSTIS
BARIUM CHLORIDE DIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 28 CENSORED DEATHS 10 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 305 482 543 543 565 578 605 612 655 671 |
| 673 673 681 681 684 687 691 701 701 703 |
| 708 708 708 708 712 722 722 723 |
| CENSORED DEATHS |
| 452 452 452 452 453 453 453 453 453 453 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 520 537 544 562 565 565 565 580 615 653 |
| 658 661 669 670 673 687 708 723 724 |
| CENSORED DEATHS |
| 452 452 452 452 452 452 453 453 453 453 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 10 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 506 520 528 543 590 591 621 636 655 661 |
| 667 683 688 704 708 709 709 711 717 719 |
| 723 |
| CENSORED DEATHS |
| 452 452 452 452 453 453 453 453 453 453 |
| |
==================================================================================
BARIUM CHLORIDE DIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 312 397 520 559 564 564 582 601 615 620 |
| 633 659 669 674 675 681 726 |
| CENSORED DEATHS |
| 452 452 452 452 452 452 453 453 453 453 |
| |
==================================================================================
BARIUM CHLORIDE DIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 98.3 98.3 96.3 92.3 86.3 82.3 44.1 |
| | |
| | |
|500 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 84.0 76.0 62.0 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 92.0 88.0 80.0 58.0 |
| | |
| | |
|2500 PPM | 100.0 100.0 100.0 98.3 96.7 96.7 94.7 84.6 76.5 66.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 500 PPM 1250 PPM 2500 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 44.1% 62.0% 58.0% 66.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.153N P=0.193N P=0.236N P=0.111N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 648.0 625.2 647.1 591.2 |
|NATURAL DEATHS (C) | (17.6) (15.5) (15.9) (25.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 645.5 650.6 654.8 644.4 |
|(STANDARD ERROR) | (14.7) (13.9) (13.9) (15.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BARIUM CHLORIDE DIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 359 380 462 526 575 575 589 591 606 625 |
| 634 645 652 653 658 687 687 692 698 |
| CENSORED DEATHS |
| 456 456 456 456 456 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 14 CENSORED DEATHS 10 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 428 457 477 647 666 689 695 706 706 706 |
| 707 707 713 713 |
| CENSORED DEATHS |
| 456 456 456 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 310 430 462 483 520 541 627 643 643 668 |
| 673 |
| CENSORED DEATHS |
| 456 456 456 456 456 458 458 458 458 458 |
| |
==================================================================================
BARIUM CHLORIDE DIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 493 510 527 563 617 621 644 647 650 669 |
| 669 679 692 699 707 707 730 730 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 458 458 458 |
| |
==================================================================================
BARIUM CHLORIDE DIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 737 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 737 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 98.3 96.7 94.7 92.6 84.6 70.5 62.4 |
| | |
| | |
|500 PPM | 100.0 100.0 100.0 100.0 100.0 94.6 94.6 94.6 92.6 72.4 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 98.3 98.3 92.6 88.6 88.6 82.6 78.5 |
| | |
| | |
|2500 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 92.0 82.0 64.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 500 PPM 1250 PPM 2500 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.4% 72.4% 78.5% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.969N P=0.231N P=0.155N P=0.789N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 594.4 644.1 545.5 641.9 |
|NATURAL DEATHS (C) | (22.8) (28.1) (35.3) (17.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 645.2 668.7 655.2 661.7 |
|(STANDARD ERROR) | (15.4) (14.7) (16.2) (14.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BARIUM CHLORIDE DIHYDRATE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
500 PPM = 2
1250 PPM = 3
2500 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 4 3 2
| 1 4 4 1 3 2 21
| 3322 42
| 1 41 3
P 90 + 1 1
E | 4 14 34113
R | 2 2 4 13 3 1
C | 24 1 31
E 80 + 4 4 311
N | 4 2 2311
T | 22433 3
| 22 33
S 70 + 211
U | 42 2 4 4
R | 1 1232
V | 2 2
I 60 + 1133
V | 3 3
A |
L |
50 + 1 1
|
| 1 1
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 35 obs hidden.
BARIUM CHLORIDE DIHYDRATE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
500 PPM = 2
1250 PPM = 3
2500 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2 4
| 3 1 1 2 2
| 4 4
| 1 3 1 2 4 4
95 + 1 2 1 2
| 4 4
| 3 31 4 1 4 2 2
| 3 3
P 90 + 2 2
E | 3 1 1 3 22
R | 4 4
C | 3 34 22
E 85 + 1 1
N |
T | 1 1 34 3
|
S 80 + 11 33
U | 1 1 3 3
R | 44
V | 11 4 4 22
I 75 +
V | 44
A | 442 2
L |
70 + 1 1
|
| 4 4
|
65 + 11
| 44
| 1 1
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.