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TDMS Study 05128-06 Pathology Tables




NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00
Route: DOSED FEED                                                                                                 Time: 08:27:12




       Facility:  Southern Research Institute

       Chemical CAS #:  8003-22-3

       Lock Date:  01/12/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 3| 6| 7| 7| 6| 6| 7| 3| 7| 6| 5| 7| 6|             
                             DAY ON TEST   | 4| 5| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 5| 6| 1| 4| 0| 8| 4| 5| 4| 9| 7| 4| 0|             
                                           | 2| 8| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 8| 0| 2| 2| 7| 4| 2| 8| 2| 9| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |          X                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                                    X                     |             
      Leukemia Mononuclear                 |       X        X  X     X                                               X|             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +        +        +                       +  +              +      |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                 X|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 3| 6| 7| 7| 6| 6| 7| 3| 7| 6| 5| 7| 6|             
                             DAY ON TEST   | 4| 5| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 5| 6| 1| 4| 0| 8| 4| 5| 4| 9| 7| 4| 0|             
                                           | 2| 8| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 8| 0| 2| 2| 7| 4| 2| 8| 2| 9| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X                                               X|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                     X|             
      Pheochromocytoma Complex             |                                           X                              |             
      Pheochromocytoma Benign              |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Pars Distalis, Adenoma               | X        X  X     X  X     X  X           X           X     X  X     X   |             
      Pars Distalis, Adenoma, Multiple     |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |       X                                                     X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 3| 6| 7| 7| 6| 6| 7| 3| 7| 6| 5| 7| 6|             
                             DAY ON TEST   | 4| 5| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 5| 6| 1| 4| 0| 8| 4| 5| 4| 9| 7| 4| 0|             
                                           | 2| 8| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 8| 0| 2| 2| 7| 4| 2| 8| 2| 9| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                    X                 X     X                 X   |             
      Carcinoma                            |                                        X                    X            |             
      Bilateral, Carcinoma                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Polyp Stromal                        |    X     X        X        X                       X  X                 X|             
      Polyp Stromal, Multiple              |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                M                                M                       M|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X  X     X                          X                    X|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +           +                                   +                    +|             
      Mediastinal, Leukemia Mononuclear    |                                                                         X|             
      Pancreatic, Leukemia Mononuclear     |                X                                   X                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X           X     X                          X                    X|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X  X     X                                               X|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +                                                                     |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X  X     X                          X                    X|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 3| 6| 7| 7| 6| 6| 7| 3| 7| 6| 5| 7| 6|             
                             DAY ON TEST   | 4| 5| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 5| 6| 1| 4| 0| 8| 4| 5| 4| 9| 7| 4| 0|             
                                           | 2| 8| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 8| 0| 2| 2| 7| 4| 2| 8| 2| 9| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                           X                              |             
      Carcinoma                            |                   X        X                             X        X      |             
      Fibroadenoma                         | X           X           X  X                 X                       X   |             
      Fibroadenoma, Multiple               |          X           X        X        X                                 |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                X         |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
      Leukemia Mononuclear                 |                                                    X                    X|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 3| 6| 7| 7| 6| 6| 7| 3| 7| 6| 5| 7| 6|             
                             DAY ON TEST   | 4| 5| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 5| 6| 1| 4| 0| 8| 4| 5| 4| 9| 7| 4| 0|             
                                           | 2| 8| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 8| 0| 2| 2| 7| 4| 2| 8| 2| 9| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                        X|             
      Transitional Epithelium, Carcinoma   |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X  X     X                          X                    X|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 3| 7| 7| 5| 7| 5| 3| 7|             
                             DAY ON TEST   | 4| 5| 4| 4| 4| 7| 5| 3| 4| 4| 4| 4| 5| 3| 4| 5| 4| 5| 3| 4| 7| 4| 8| 5| 4|             
                                           | 2| 8| 2| 2| 2| 2| 8| 0| 2| 2| 2| 2| 8| 4| 2| 1| 2| 8| 4| 2| 0| 2| 9| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                                                          |             
      Leukemia Mononuclear                 |          X  X        X  X     X  X     X              X           X      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                            +           +              +  +        +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                           +                              |             
      Squamous Cell Papilloma              |                                           X                              |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 3| 7| 7| 5| 7| 5| 3| 7|             
                             DAY ON TEST   | 4| 5| 4| 4| 4| 7| 5| 3| 4| 4| 4| 4| 5| 3| 4| 5| 4| 5| 3| 4| 7| 4| 8| 5| 4|             
                                           | 2| 8| 2| 2| 2| 2| 8| 0| 2| 2| 2| 2| 8| 4| 2| 1| 2| 8| 4| 2| 0| 2| 9| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
   Tooth                                   |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                          X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                             X                                 |             
      Pars Distalis, Adenoma               | X     X        X     X     X  X              X                           |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 3| 7| 7| 5| 7| 5| 3| 7|             
                             DAY ON TEST   | 4| 5| 4| 4| 4| 7| 5| 3| 4| 4| 4| 4| 5| 3| 4| 5| 4| 5| 3| 4| 7| 4| 8| 5| 4|             
                                           | 2| 8| 2| 2| 2| 2| 8| 0| 2| 2| 2| 2| 8| 4| 2| 1| 2| 8| 4| 2| 0| 2| 9| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X              X     X        X                                X|             
      Carcinoma                            |                      X                          X              X         |             
      Bilateral, Carcinoma                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                           X                              |             
      Polyp Stromal                        |                                              X        X     X            |             
      Polyp Stromal, Multiple              |             X                                                            |             
      Schwannoma Malignant                 |                                                             X            |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                           M                             +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X        X                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                        +  +              +        +      |             
      Mediastinal, Leukemia Mononuclear    |                                                                   X      |             
      Pancreatic, Leukemia Mononuclear     |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X                          X                          X      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X        X                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X        X  X     X  X     X              X           X      |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 3| 7| 7| 5| 7| 5| 3| 7|             
                             DAY ON TEST   | 4| 5| 4| 4| 4| 7| 5| 3| 4| 4| 4| 4| 5| 3| 4| 5| 4| 5| 3| 4| 7| 4| 8| 5| 4|             
                                           | 2| 8| 2| 2| 2| 2| 8| 0| 2| 2| 2| 2| 8| 4| 2| 1| 2| 8| 4| 2| 0| 2| 9| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |             X           X        X              X                       X|             
      Fibroadenoma, Multiple               |                      X                                X        X         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                              +                           |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                         +                    +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Carcinoma, Metastatic, Uterus        |                                           X                              |             
      Leukemia Mononuclear                 |          X                                                        X      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 3| 7| 7| 5| 7| 5| 3| 7|             
                             DAY ON TEST   | 4| 5| 4| 4| 4| 7| 5| 3| 4| 4| 4| 4| 5| 3| 4| 5| 4| 5| 3| 4| 7| 4| 8| 5| 4|             
                                           | 2| 8| 2| 2| 2| 2| 8| 0| 2| 2| 2| 2| 8| 4| 2| 1| 2| 8| 4| 2| 0| 2| 9| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X        X  X     X  X     X              X           X      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 7| 5| 7| 6| 3| 7|                                            |            |
                             DAY ON TEST   | 8| 5| 3| 0| 4| 3| 4| 2| 5| 4|                                            |            |
                                           | 1| 8| 4| 0| 2| 7| 2| 9| 8| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cholangiocarcinoma                   |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |         15 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  12        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 7| 5| 7| 6| 3| 7|                                            |            |
                             DAY ON TEST   | 8| 5| 3| 0| 4| 3| 4| 2| 5| 4|                                            |            |
                                           | 1| 8| 4| 0| 2| 7| 2| 9| 8| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |          X                                                               |          5 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 |          X                                                               |          4 |
      Pheochromocytoma Complex             |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pars Distalis, Adenoma               |       X        X     X     X                                             |         23 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 7| 5| 7| 6| 3| 7|                                            |            |
                             DAY ON TEST   | 8| 5| 3| 0| 4| 3| 4| 2| 5| 4|                                            |            |
                                           | 1| 8| 4| 0| 2| 7| 2| 9| 8| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Adenoma                      |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenoma                              |                      X                                                   |         11 |
      Carcinoma                            |                                                                          |          5 |
      Bilateral, Carcinoma                 |                   X                                                      |          1 |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          1 |
      Polyp Stromal                        |       X              X  X                                                |         13 |
      Polyp Stromal, Multiple              |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |          M           M                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |          X                                                               |         10 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +        +                                                               |  10        |
      Mediastinal, Leukemia Mononuclear    |          X                                                               |          3 |
      Pancreatic, Leukemia Mononuclear     |          X                                                               |          4 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 7| 5| 7| 6| 3| 7|                                            |            |
                             DAY ON TEST   | 8| 5| 3| 0| 4| 3| 4| 2| 5| 4|                                            |            |
                                           | 1| 8| 4| 0| 2| 7| 2| 9| 8| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |          X                                                               |         10 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |          X                                                               |          9 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |          X                                                               |         16 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |          X                                                               |          2 |
      Carcinoma                            | X                                                                        |          5 |
      Fibroadenoma                         |       X  X                 X                                             |         14 |
      Fibroadenoma, Multiple               |                                                                          |          7 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  I  +  +  +  +                                             |  59        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Osteosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 7| 5| 7| 6| 3| 7|                                            |            |
                             DAY ON TEST   | 8| 5| 3| 0| 4| 3| 4| 2| 5| 4|                                            |            |
                                           | 1| 8| 4| 0| 2| 7| 2| 9| 8| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |          +                                                               |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |          +                                                               |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |          X                                                               |         16 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 3| 7| 3| 7| 7| 6| 7| 3| 6| 6| 5| 6| 7| 6| 3| 6| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 5| 4| 5| 4| 4| 7| 4| 5| 2| 3| 4| 8| 4| 8| 5| 2| 2| 0| 4| 4| 4|             
                                           | 4| 0| 2| 0| 8| 0| 8| 0| 0| 2| 0| 8| 2| 1| 8| 8| 0| 8| 8| 9| 6| 8| 0| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                      X                                                   |             
      Hepatocellular Adenoma, Multiple     |                                                                      X   |             
      Leukemia Mononuclear                 |                         X  X  X        X     X           X  X  X     X   |             
      Lymphoma Malignant                   |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                             +     +  +     +           +  +        +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 3| 7| 3| 7| 7| 6| 7| 3| 6| 6| 5| 6| 7| 6| 3| 6| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 5| 4| 5| 4| 4| 7| 4| 5| 2| 3| 4| 8| 4| 8| 5| 2| 2| 0| 4| 4| 4|             
                                           | 4| 0| 2| 0| 8| 0| 8| 0| 0| 2| 0| 8| 2| 1| 8| 8| 0| 8| 8| 9| 6| 8| 0| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                 X                        |             
      Leukemia Mononuclear                 |                         X              X                    X            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                X  X            |             
      Pheochromocytoma Benign              |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 3| 7| 3| 7| 7| 6| 7| 3| 6| 6| 5| 6| 7| 6| 3| 6| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 5| 4| 5| 4| 4| 7| 4| 5| 2| 3| 4| 8| 4| 8| 5| 2| 2| 0| 4| 4| 4|             
                                           | 4| 0| 2| 0| 8| 0| 8| 0| 0| 2| 0| 8| 2| 1| 8| 8| 0| 8| 8| 9| 6| 8| 0| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               | X  X                 X     X           X     X  X                       X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                      X                                                   |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
      Carcinoma                            |                                           X                              |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Polyp Stromal                        | X              X  X              X     X  X                 X     X      |             
      Schwannoma Malignant                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                        M                 M               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X                 X  X  X         |             
      Lymphoma Malignant                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                             +  +         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 3| 7| 3| 7| 7| 6| 7| 3| 6| 6| 5| 6| 7| 6| 3| 6| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 5| 4| 5| 4| 4| 7| 4| 5| 2| 3| 4| 8| 4| 8| 5| 2| 2| 0| 4| 4| 4|             
                                           | 4| 0| 2| 0| 8| 0| 8| 0| 0| 2| 0| 8| 2| 1| 8| 8| 0| 8| 8| 9| 6| 8| 0| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                X         |             
      Mediastinal, Leukemia Mononuclear    |                                                             X  X         |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                             X  X         |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                X         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X  X  X        X                    X  X     X   |             
      Lymphoma Malignant                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X           X                    X  X         |             
      Lymphoma Malignant                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                +         |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X  X  X        X     X              X  X     X   |             
      Lymphoma Malignant                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                         X|             
      Fibroadenoma                         | X     X  X           X  X  X        X     X  X              X            |             
      Fibroadenoma, Multiple               |                                                    X     X        X      |             
      Leukemia Mononuclear                 |                                                                X         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 3| 7| 3| 7| 7| 6| 7| 3| 6| 6| 5| 6| 7| 6| 3| 6| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 5| 4| 5| 4| 4| 7| 4| 5| 2| 3| 4| 8| 4| 8| 5| 2| 2| 0| 4| 4| 4|             
                                           | 4| 0| 2| 0| 8| 0| 8| 0| 0| 2| 0| 8| 2| 1| 8| 8| 0| 8| 8| 9| 6| 8| 0| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                      +   |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Leukemia Mononuclear                 |                                        X                    X  X         |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                           |__________________________________________________________________________|             
   Eye                                     |       +                 +                                                |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 3| 7| 3| 7| 7| 6| 7| 3| 6| 6| 5| 6| 7| 6| 3| 6| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 5| 4| 5| 4| 4| 7| 4| 5| 2| 3| 4| 8| 4| 8| 5| 2| 2| 0| 4| 4| 4|             
                                           | 4| 0| 2| 0| 8| 0| 8| 0| 0| 2| 0| 8| 2| 1| 8| 8| 0| 8| 8| 9| 6| 8| 0| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                   X  X         |             
      Lymphoma Malignant                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X  X  X        X     X           X  X  X     X   |             
      Lymphoma Malignant                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 3| 6| 7|             
                             DAY ON TEST   | 2| 5| 4| 0| 4| 4| 5| 4| 4| 4| 0| 5| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 5| 4|             
                                           | 8| 8| 0| 5| 0| 0| 8| 0| 0| 2| 1| 8| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 8| 6| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |             X                                                            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Leukemia Mononuclear                 |             X              X  X           X  X  X     X              X  X|             
      Lymphoma Malignant                   | X                                                                        |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                 +        +           +     +              +            |             
      Leukemia Mononuclear                 |                                              X                           |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +                                                                        |             
      Squamous Cell Papilloma              | X                                                                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 3| 6| 7|             
                             DAY ON TEST   | 2| 5| 4| 0| 4| 4| 5| 4| 4| 4| 0| 5| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 5| 4|             
                                           | 8| 8| 0| 5| 0| 0| 8| 0| 0| 2| 1| 8| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 8| 6| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Squamous Cell Carcinoma              |                                                 X                        |             
      Squamous Cell Papilloma              |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |             X                                X                           |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 3| 6| 7|             
                             DAY ON TEST   | 2| 5| 4| 0| 4| 4| 5| 4| 4| 4| 0| 5| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 5| 4|             
                                           | 8| 8| 0| 5| 0| 0| 8| 0| 0| 2| 1| 8| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 8| 6| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |       X  X     X        X     X     X  X        X  X  X     X            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                        X                                 |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X                                                         |             
      Carcinoma                            |                                                       X                  |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Polyp Stromal                        |                         X                 X     X  X                 X   |             
      Schwannoma Malignant                 |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Vagina                                  | M                                                  M  M                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X                 X        X              X   |             
      Lymphoma Malignant                   | X                                                                        |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +        +     +           +                    +  +              +   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 3| 6| 7|             
                             DAY ON TEST   | 2| 5| 4| 0| 4| 4| 5| 4| 4| 4| 0| 5| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 5| 4|             
                                           | 8| 8| 0| 5| 0| 0| 8| 0| 0| 2| 1| 8| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 8| 6| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |             X                 X                       X              X   |             
      Mediastinal, Lymphoma Malignant      | X                                                                        |             
      Pancreatic, Leukemia Mononuclear     |                                                       X                  |             
      Pancreatic, Lymphoma Malignant       | X                                                                        |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X           X  X        X                  |             
      Lymphoma Malignant                   | X                                                                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                             X  X        X              X   |             
      Lymphoma Malignant                   | X                                                                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +              +                                                      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X  X           X  X  X     X              X  X|             
      Lymphoma Malignant                   | X                                                                        |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            | X                                   X  X  X                              |             
      Fibroadenoma                         |                                                 X                        |             
      Fibroadenoma, Multiple               |                            X                             X  X  X         |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 3| 6| 7|             
                             DAY ON TEST   | 2| 5| 4| 0| 4| 4| 5| 4| 4| 4| 0| 5| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 5| 4|             
                                           | 8| 8| 0| 5| 0| 0| 8| 0| 0| 2| 1| 8| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 8| 6| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                    X                     |             
      Leukemia Mononuclear                 |                            X                                             |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                    +                     |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                X                                                         |             
      Leukemia Mononuclear                 |             X                             X  X                       X   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 3| 6| 7|             
                             DAY ON TEST   | 2| 5| 4| 0| 4| 4| 5| 4| 4| 4| 0| 5| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 5| 4|             
                                           | 8| 8| 0| 5| 0| 0| 8| 0| 0| 2| 1| 8| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 8| 6| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X                 X                           |             
      Lymphoma Malignant                   | X                                                                        |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X  X           X  X  X     X              X  X|             
      Lymphoma Malignant                   | X                                                                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 3| 5| 4| 7|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 0| 4| 4| 5| 4| 6| 4|                                            |            |
                                           | 1| 1| 1| 0| 1| 1| 8| 6| 2| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.05%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | M  I  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 |             X  X     X                                                   |         21 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +           +  +  +  +                                             |  20        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 3| 5| 4| 7|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 0| 4| 4| 5| 4| 6| 4|                                            |            |
                                           | 1| 1| 1| 0| 1| 1| 8| 6| 2| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.05%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
      Osteosarcoma, Metastatic, Bone       |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +     +           +  +  +                                                |  55        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |             X                                                            |          2 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          6 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |          5 |
      Pheochromocytoma Benign              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 3| 5| 4| 7|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 0| 4| 4| 5| 4| 6| 4|                                            |            |
                                           | 1| 1| 1| 0| 1| 1| 8| 6| 2| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.05%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
      Pars Distalis, Adenoma               |    X  X     X              X                                             |         23 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      C-Cell, Adenoma                      |             X                                                            |          2 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenoma                              |    X           X                                                         |          4 |
      Carcinoma                            |                   X                                                      |          3 |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
      Osteosarcoma, Metastatic, Bone       |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 3| 5| 4| 7|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 0| 4| 4| 5| 4| 6| 4|                                            |            |
                                           | 1| 1| 1| 0| 1| 1| 8| 6| 2| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.05%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Polyp Stromal                        |                                                                          |         13 |
      Schwannoma Malignant                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |         11 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |          +  +           +                                                |  13        |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |             X                                                            |          7 |
      Mediastinal, Lymphoma Malignant      |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          3 |
      Pancreatic, Lymphoma Malignant       |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |         13 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          9 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   3        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                X     X                                                   |         19 |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 3| 5| 4| 7|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 0| 4| 4| 5| 4| 6| 4|                                            |            |
                                           | 1| 1| 1| 0| 1| 1| 8| 6| 2| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.05%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 |                      X                                                   |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          5 |
      Fibroadenoma                         |             X  X                                                         |         13 |
      Fibroadenoma, Multiple               |       X  X                                                               |          9 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Osteosarcoma                         |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                                |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 3| 5| 4| 7|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 0| 4| 4| 5| 4| 6| 4|                                            |            |
                                           | 1| 1| 1| 0| 1| 1| 8| 6| 2| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.05%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          8 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |          7 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |             X  X     X                                                   |         21 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 3| 5| 4| 7|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 0| 4| 4| 5| 4| 6| 4|                                            |            |
                                           | 1| 1| 1| 0| 1| 1| 8| 6| 2| 1|                                            |            |
 _____________________________________________________________________________________________________________________      T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.05%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 3| 7| 7| 7| 5| 3| 6| 3| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 5| 4| 5| 4| 4| 4| 9| 5| 5| 5| 4| 4| 6| 4| 3| 4| 4| 5| 4| 4| 4| 4|             
                                           | 0| 0| 1| 8| 0| 8| 0| 0| 0| 7| 8| 8| 8| 0| 0| 0| 0| 2| 0| 0| 8| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.17%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                   X     X                                         X      |             
      Leukemia Mononuclear                 |       X           X        X           X           X              X      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                            +                       +  +                  |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 3| 7| 7| 7| 5| 3| 6| 3| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 5| 4| 5| 4| 4| 4| 9| 5| 5| 5| 4| 4| 6| 4| 3| 4| 4| 5| 4| 4| 4| 4|             
                                           | 0| 0| 1| 8| 0| 8| 0| 0| 0| 7| 8| 8| 8| 0| 0| 0| 0| 2| 0| 0| 8| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.17%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                    X                       X                     |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                   X              X                                       |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Adenoma                              |                                                          X               |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |             X                    X           X        X        X         |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                   X                                                      |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                                                    X   |             
      Carcinoma                            |                         X                                X              X|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                           X                              |             
      Granulosa Cell Tumor Benign          |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 3| 7| 7| 7| 5| 3| 6| 3| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 5| 4| 5| 4| 4| 4| 9| 5| 5| 5| 4| 4| 6| 4| 3| 4| 4| 5| 4| 4| 4| 4|             
                                           | 0| 0| 1| 8| 0| 8| 0| 0| 0| 7| 8| 8| 8| 0| 0| 0| 0| 2| 0| 0| 8| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.17%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Polyp Stromal                        |                X              X  X  X                    X               |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                     M              M                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X              X                       X              X      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +              +     +  +     +              +                     |             
      Mediastinal, Leukemia Mononuclear    |       X                    X                       X                     |             
      Pancreatic, Leukemia Mononuclear     |                            X                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X           X                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                    X                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                               +     +                                    |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X     X              X           X           X              X      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                      X   |             
      Carcinoma, Multiple                  |                                                                          |             
      Fibroadenoma                         |       X              X  X                       X     X                  |             
      Fibroadenoma, Multiple               |                                           X  X           X        X      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |             X                                                            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 3| 7| 7| 7| 5| 3| 6| 3| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 5| 4| 5| 4| 4| 4| 9| 5| 5| 5| 4| 4| 6| 4| 3| 4| 4| 5| 4| 4| 4| 4|             
                                           | 0| 0| 1| 8| 0| 8| 0| 0| 0| 7| 8| 8| 8| 0| 0| 0| 0| 2| 0| 0| 8| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.17%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                         X                                                |             
      Leukemia Mononuclear                 |       X                    X                                             |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                    X                       X                     |             
      Sarcoma                              |                                                                          |             
      Renal Tubule, Carcinoma              |                                                                          |             
      Transitional Epithelium, Hemangioma  |                                           X                              |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X     X     X        X           X           X              X      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 3| 5| 7|             
                             DAY ON TEST   | 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 1| 2| 4| 4| 4| 7| 4| 3| 4| 4| 4| 4| 5| 8| 4|             
                                           | 1| 1| 8| 1| 1| 8| 1| 1| 1| 1| 9| 2| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 8| 8| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.17%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                         X|             
      Leukemia Mononuclear                 |             X              X  X  X     X     X                 X     X   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                       +  +           +   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 3| 5| 7|             
                             DAY ON TEST   | 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 1| 2| 4| 4| 4| 7| 4| 3| 4| 4| 4| 4| 5| 8| 4|             
                                           | 1| 1| 8| 1| 1| 8| 1| 1| 1| 1| 9| 2| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 8| 8| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.17%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X     X                             X   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                              X                           |             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X              X     X        X  X     X     X  X  X  X     X        X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                  X  X     X                              |             
      C-Cell, Carcinoma                    |                                                    X                     |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Adenoma                              |                                                 X                       X|             
      Carcinoma                            |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                                                          |             
      Granulosa Cell Tumor Benign          |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 3| 5| 7|             
                             DAY ON TEST   | 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 1| 2| 4| 4| 4| 7| 4| 3| 4| 4| 4| 4| 5| 8| 4|             
                                           | 1| 1| 8| 1| 1| 8| 1| 1| 1| 1| 9| 2| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 8| 8| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.17%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Polyp Stromal                        |          X  X                             X        X        X            |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X  X  X                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                  +                 +        +        +   |             
      Mediastinal, Leukemia Mononuclear    |                                                                      X   |             
      Pancreatic, Leukemia Mononuclear     |                                  X                                   X   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X  X                                   X   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X        X  X  X     X                       X     X   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                       X                  |             
      Carcinoma, Multiple                  |                                  X                                       |             
      Fibroadenoma                         | X        X           X              X        X     X  X  X              X|             
      Fibroadenoma, Multiple               |                               X                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                    X                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 3| 5| 7|             
                             DAY ON TEST   | 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 1| 2| 4| 4| 4| 7| 4| 3| 4| 4| 4| 4| 5| 8| 4|             
                                           | 1| 1| 8| 1| 1| 8| 1| 1| 1| 1| 9| 2| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 8| 8| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.17%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                          X               |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X     X                                 |             
      Sarcoma                              |                                                                         X|             
      Renal Tubule, Carcinoma              |                                                       X                  |             
      Transitional Epithelium, Hemangioma  |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X        X  X  X     X     X                 X     X   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 4| 6| 7| 7| 3| 7| 7|                                            |            |
                             DAY ON TEST   | 4| 5| 4| 5| 1| 4| 2| 5| 4| 4|                                            |            |
                                           | 1| 8| 1| 6| 0| 1| 2| 8| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.17%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Adenoma               |                            X                                             |          5 |
      Leukemia Mononuclear                 |                   X     X                                                |         16 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +        +                                                               |   8        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 4| 6| 7| 7| 3| 7| 7|                                            |            |
                             DAY ON TEST   | 4| 5| 4| 5| 1| 4| 2| 5| 4| 4|                                            |            |
                                           | 1| 8| 1| 6| 0| 1| 2| 8| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.17%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +                                             |  57        |
      Adenoma                              |       X                                                                  |          1 |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Adenoma               |             X                                                            |         18 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Adenoma                      |                                                                          |          4 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 4| 6| 7| 7| 3| 7| 7|                                            |            |
                             DAY ON TEST   | 4| 5| 4| 5| 1| 4| 2| 5| 4| 4|                                            |            |
                                           | 1| 8| 1| 6| 0| 1| 2| 8| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.17%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                            X                                             |          5 |
      Carcinoma                            |          X     X                                                         |          6 |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
      Granulosa Cell Tumor Benign          | X                                                                        |          1 |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Polyp Stromal                        |                                                                          |         10 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                         X                                                |          9 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +        +                                                               |  13        |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          4 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                         X                                                |          7 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                         X                                                |          4 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                         X                                                |         16 |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 4| 6| 7| 7| 3| 7| 7|                                            |            |
                             DAY ON TEST   | 4| 5| 4| 5| 1| 4| 2| 5| 4| 4|                                            |            |
                                           | 1| 8| 1| 6| 0| 1| 2| 8| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.17%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
   Thymus                                  | +  +  +  +  M  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          2 |
      Carcinoma, Multiple                  |                                                                          |          1 |
      Fibroadenoma                         | X        X        X     X                                                |         18 |
      Fibroadenoma, Multiple               |                                                                          |          5 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Squamous Cell Carcinoma              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 4| 6| 7| 7| 3| 7| 7|                                            |            |
                             DAY ON TEST   | 4| 5| 4| 5| 1| 4| 2| 5| 4| 4|                                            |            |
                                           | 1| 8| 1| 6| 0| 1| 2| 8| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.17%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Sarcoma                              |                                                                          |          1 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
      Transitional Epithelium, Hemangioma  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                   X     X                                                |         19 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 3| 4| 7| 6| 7|             
                             DAY ON TEST   | 5| 4| 5| 9| 2| 4| 5| 2| 4| 4| 4| 3| 3| 5| 4| 2| 6| 4| 4| 2| 5| 4| 2| 5| 4|             
                                           | 6| 8| 8| 5| 3| 0| 8| 3| 0| 0| 0| 3| 4| 8| 0| 8| 9| 0| 0| 8| 8| 1| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |          X                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                                                      X   |             
      Hepatocellular Carcinoma             |                                              X                           |             
      Hepatocellular Adenoma               |                            X                                      X      |             
      Leukemia Mononuclear                 |    X     X  X                                X  X              X  X  X   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +        +  +  +  +              +     +                 +   |             
      Cholangiocarcinoma, Metastatic, Liver|                                                                      X   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 3| 4| 7| 6| 7|             
                             DAY ON TEST   | 5| 4| 5| 9| 2| 4| 5| 2| 4| 4| 4| 3| 3| 5| 4| 2| 6| 4| 4| 2| 5| 4| 2| 5| 4|             
                                           | 6| 8| 8| 5| 3| 0| 8| 3| 0| 0| 0| 3| 4| 8| 0| 8| 9| 0| 0| 8| 8| 1| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                  +                                       |             
      Squamous Cell Carcinoma              |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X                                   X              X         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Pheochromocytoma Malignant           |                      X                                                   |             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X           X           X     X  X                                X      |             
      Pars Distalis, Carcinoma             |                      X                    X                              |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 3| 4| 7| 6| 7|             
                             DAY ON TEST   | 5| 4| 5| 9| 2| 4| 5| 2| 4| 4| 4| 3| 3| 5| 4| 2| 6| 4| 4| 2| 5| 4| 2| 5| 4|             
                                           | 6| 8| 8| 5| 3| 0| 8| 3| 0| 0| 0| 3| 4| 8| 0| 8| 9| 0| 0| 8| 8| 1| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Follicular Cell, Carcinoma|                                                                          |             
      C-Cell, Adenoma                      |                      X     X                                             |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      Follicular Cell, Adenoma             |             X                                                     X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                    X        X                                         X|             
      Carcinoma                            |                   X                          X        X                  |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X                           |             
      Cholangiocarcinoma, Metastatic, Liver|                                                                      X   |             
      Polyp Stromal                        |    X     X                       X  X                                    |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                  M                                M      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X                                X  X              X  X      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +     +  +  +                       +              +         |             
      Leukemia Mononuclear                 |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |             X                                   X                        |             
      Pancreatic, Leukemia Mononuclear     |                                                                X         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 3| 4| 7| 6| 7|             
                             DAY ON TEST   | 5| 4| 5| 9| 2| 4| 5| 2| 4| 4| 4| 3| 3| 5| 4| 2| 6| 4| 4| 2| 5| 4| 2| 5| 4|             
                                           | 6| 8| 8| 5| 3| 0| 8| 3| 0| 0| 0| 3| 4| 8| 0| 8| 9| 0| 0| 8| 8| 1| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X        X                                X  X              X  X      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                X                           |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                   +                                                  +   |             
      Cholangiocarcinoma, Metastatic, Liver|                                                                      X   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Leukemia Mononuclear                 |    X     X  X                                X  X              X  X  X   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                   X                                                      |             
      Fibroadenoma                         | X        X                    X  X                       X               |             
      Fibroadenoma, Multiple               |                X     X     X        X                             X  X   |             
      Histiocytic Sarcoma                  |          X                                                               |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Histiocytic Sarcoma                  |          X                                                               |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                                   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 3| 4| 7| 6| 7|             
                             DAY ON TEST   | 5| 4| 5| 9| 2| 4| 5| 2| 4| 4| 4| 3| 3| 5| 4| 2| 6| 4| 4| 2| 5| 4| 2| 5| 4|             
                                           | 6| 8| 8| 5| 3| 0| 8| 3| 0| 0| 0| 3| 4| 8| 0| 8| 9| 0| 0| 8| 8| 1| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Rhabdomyosarcoma                     |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                           X                              |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |             +        +                                                   |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |             +        +                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Cholangiocarcinoma, Metastatic, Liver|                                                                      X   |             
      Leukemia Mononuclear                 |    X        X                                   X                        |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 3| 4| 7| 6| 7|             
                             DAY ON TEST   | 5| 4| 5| 9| 2| 4| 5| 2| 4| 4| 4| 3| 3| 5| 4| 2| 6| 4| 4| 2| 5| 4| 2| 5| 4|             
                                           | 6| 8| 8| 5| 3| 0| 8| 3| 0| 0| 0| 3| 4| 8| 0| 8| 9| 0| 0| 8| 8| 1| 0| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                            X                    X   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Papilloma                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |          X                                                               |             
      Leukemia Mononuclear                 |    X     X  X                                X  X              X  X  X   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 7| 6| 7| 3| 6| 7| 7| 5| 7| 7| 5| 3| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7|             
                             DAY ON TEST   | 9| 5| 4| 2| 7| 4| 5| 5| 4| 4| 0| 4| 4| 3| 5| 0| 6| 4| 4| 1| 4| 4| 4| 5| 2|             
                                           | 6| 8| 0| 8| 2| 0| 8| 8| 0| 0| 6| 0| 0| 0| 8| 0| 8| 0| 1| 2| 1| 1| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                    X                     |             
      Leukemia Mononuclear                 | X                    X  X                          X     X              X|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                +        +                 +     +                    +   |             
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Squamous Cell Papilloma              |                         X                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 7| 6| 7| 3| 6| 7| 7| 5| 7| 7| 5| 3| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7|             
                             DAY ON TEST   | 9| 5| 4| 2| 7| 4| 5| 5| 4| 4| 0| 4| 4| 3| 5| 0| 6| 4| 4| 1| 4| 4| 4| 5| 2|             
                                           | 6| 8| 0| 8| 2| 0| 8| 8| 0| 0| 6| 0| 0| 0| 8| 0| 8| 0| 1| 2| 1| 1| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Osteosarcoma, Metastatic, Bone       |                                        X                                 |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                  X     X               |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                      X                                   X               |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X                           |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Pars Distalis, Adenoma               |       X  X  X     X        X                 X        X  X  X  X     X  X|             
      Pars Distalis, Carcinoma             |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 7| 6| 7| 3| 6| 7| 7| 5| 7| 7| 5| 3| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7|             
                             DAY ON TEST   | 9| 5| 4| 2| 7| 4| 5| 5| 4| 4| 0| 4| 4| 3| 5| 0| 6| 4| 4| 1| 4| 4| 4| 5| 2|             
                                           | 6| 8| 0| 8| 2| 0| 8| 8| 0| 0| 6| 0| 0| 0| 8| 0| 8| 0| 1| 2| 1| 1| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Follicular Cell, Carcinoma|                                                                          |             
      C-Cell, Adenoma                      |                                                                   X      |             
      C-Cell, Adenoma, Multiple            |                                                          X               |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |             
      Polyp Stromal                        |                            X                             X               |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                 M        M               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                             X     X               |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                    +                 +        +  +     +           +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Deep Cervical, Leukemia Mononuclear  |                      X                                                   |             
      Mediastinal, Leukemia Mononuclear    | X                    X                             X     X               |             
      Pancreatic, Leukemia Mononuclear     |                                                    X     X               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 7| 6| 7| 3| 6| 7| 7| 5| 7| 7| 5| 3| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7|             
                             DAY ON TEST   | 9| 5| 4| 2| 7| 4| 5| 5| 4| 4| 0| 4| 4| 3| 5| 0| 6| 4| 4| 1| 4| 4| 4| 5| 2|             
                                           | 6| 8| 0| 8| 2| 0| 8| 8| 0| 0| 6| 0| 0| 0| 8| 0| 8| 0| 1| 2| 1| 1| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 | X                    X  X                          X     X               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                      +   |             
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |    X                                                                     |             
      Leukemia Mononuclear                 | X                    X  X                          X     X               |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                               X                                          |             
      Fibroadenoma                         |       X  X     X     X  X  X     X              X           X  X         |             
      Fibroadenoma, Multiple               |                                     X                    X              X|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                             X            |             
      Histiocytic Sarcoma                  |                                                                          |             
      Squamous Cell Papilloma              |                X                                                         |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 7| 6| 7| 3| 6| 7| 7| 5| 7| 7| 5| 3| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7|             
                             DAY ON TEST   | 9| 5| 4| 2| 7| 4| 5| 5| 4| 4| 0| 4| 4| 3| 5| 0| 6| 4| 4| 1| 4| 4| 4| 5| 2|             
                                           | 6| 8| 0| 8| 2| 0| 8| 8| 0| 0| 6| 0| 0| 0| 8| 0| 8| 0| 1| 2| 1| 1| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Rhabdomyosarcoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X                                                         |             
      Alveolar/Bronchiolar Carcinoma       |                                                                         X|             
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |             
      Leukemia Mononuclear                 |                      X                                   X               |             
      Osteosarcoma, Metastatic, Bone       |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     | +                                                                        |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |             +                                                            |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
      Carcinoma                            |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 7| 6| 7| 3| 6| 7| 7| 5| 7| 7| 5| 3| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7|             
                             DAY ON TEST   | 9| 5| 4| 2| 7| 4| 5| 5| 4| 4| 0| 4| 4| 3| 5| 0| 6| 4| 4| 1| 4| 4| 4| 5| 2|             
                                           | 6| 8| 0| 8| 2| 0| 8| 8| 0| 0| 6| 0| 0| 0| 8| 0| 8| 0| 1| 2| 1| 1| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5%                                   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Papilloma                            |                                                    X                     |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X                    X  X                          X     X              X|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 1| 7| 7| 7| 6| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 4| 4| 4| 2| 5| 4| 4| 4|                                            |            |
                                           | 0| 8| 7| 1| 1| 9| 6| 1| 1| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cholangiocarcinoma                   |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |             X                                                            |          4 |
      Leukemia Mononuclear                 |             X        X                                                   |         16 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |  14        |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |          +                                                               |   1        |
      Squamous Cell Carcinoma              |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 1| 7| 7| 7| 6| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 4| 4| 4| 2| 5| 4| 4| 4|                                            |            |
                                           | 0| 8| 7| 1| 1| 9| 6| 1| 1| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Papilloma              | X                                                                        |          2 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
      Schwannoma Malignant                 |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |             X                                                            |          1 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 1| 7| 7| 7| 6| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 4| 4| 4| 2| 5| 4| 4| 4|                                            |            |
                                           | 0| 8| 7| 1| 1| 9| 6| 1| 1| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Adenoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               |                X  X     X  X                                             |         22 |
      Pars Distalis, Carcinoma             |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bilateral, Follicular Cell, Carcinoma|                         X                                                |          1 |
      C-Cell, Adenoma                      |                   X  X                                                   |          5 |
      C-Cell, Adenoma, Multiple            |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                                                                          |          4 |
      Carcinoma                            |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                                                                          |          1 |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          6 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                   M                                                      |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 1| 7| 7| 7| 6| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 4| 4| 4| 2| 5| 4| 4| 4|                                            |            |
                                           | 0| 8| 7| 1| 1| 9| 6| 1| 1| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |         10 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +     +              +                                                   |  17        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                      X                                                   |          7 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 |             X        X                                                   |         13 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   3        |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 |             X        X                                                   |         15 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                X  X                                                      |          4 |
      Fibroadenoma                         |             X  X                                                         |         17 |
      Fibroadenoma, Multiple               |                                                                          |          9 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 1| 7| 7| 7| 6| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 4| 4| 4| 2| 5| 4| 4| 4|                                            |            |
                                           | 0| 8| 7| 1| 1| 9| 6| 1| 1| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Osteosarcoma                         |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Rhabdomyosarcoma                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                   X                                                      |          2 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       | X                                                                        |          2 |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 1| 7| 7| 7| 6| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 4| 4| 4| 2| 5| 4| 4| 4|                                            |            |
                                           | 0| 8| 7| 1| 1| 9| 6| 1| 1| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Papilloma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |             X        X                                                   |         16 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 6| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 0| 3| 6| 3| 9| 0| 3| 3| 0| 3| 5| 3| 3| 7| 9| 5| 3| 1| 5| 3| 3| 0| 3|             
                                           | 0| 7| 6| 2| 7| 3| 5| 1| 3| 3| 9| 3| 7| 3| 7| 7| 3| 0| 3| 9| 7| 3| 3| 6| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 | X     X  X  X     X  X  X  X  X        X  X  X     X  X  X           X   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                  +                 +              +      |             
      Lipoma                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 6| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 0| 3| 6| 3| 9| 0| 3| 3| 0| 3| 5| 3| 3| 7| 9| 5| 3| 1| 5| 3| 3| 0| 3|             
                                           | 0| 7| 6| 2| 7| 3| 5| 1| 3| 3| 9| 3| 7| 3| 7| 7| 3| 0| 3| 9| 7| 3| 3| 6| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                    X                 X           X               |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                      X                           |             
      Pheochromocytoma Malignant           |                                              X                 X         |             
      Pheochromocytoma Benign              |                            X                 X                           |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                X         |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X           X                                                      |             
      Pars Distalis, Adenoma               | X           X  X        X  X           X  X        X           X  X      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                   X                                                      |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      Follicular Cell, Carcinoma           |                   X        X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                      +                                                   |             
      Mesothelioma Malignant               |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 6| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 0| 3| 6| 3| 9| 0| 3| 3| 0| 3| 5| 3| 3| 7| 9| 5| 3| 1| 5| 3| 3| 0| 3|             
                                           | 0| 7| 6| 2| 7| 3| 5| 1| 3| 3| 9| 3| 7| 3| 7| 7| 3| 0| 3| 9| 7| 3| 3| 6| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                                  X|             
      Carcinoma                            |                X        X                             X                  |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                      X                                                   |             
      Bilateral, Interstitial Cell, Adenoma|          X     X  X  X  X  X     X     X     X  X     X  X           X  X|             
      Interstitial Cell, Adenoma           |       X                       X                    X              X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X  X  X  X  X              X     X  X  X           X   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +     +           +        +  +              +  +  +     +               |             
      Leukemia Mononuclear                 |                   X                          X           X               |             
      Deep Cervical, Leukemia Mononuclear  |                            X                 X     X                     |             
      Iliac, Leukemia Mononuclear          |                   X                                X                     |             
      Mediastinal, Leukemia Mononuclear    | X                 X        X  X              X     X     X               |             
      Pancreatic, Leukemia Mononuclear     |       X           X           X                    X     X               |             
      Renal, Leukemia Mononuclear          | X                                                                        |             
      Renal, Pheochromocytoma Malignant,   |                                                                          |             
           Metastatic, Adrenal Medulla     |                                              X                           |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X           X     X  X  X        X     X     X  X                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X           X        X  X        X     X     X     X               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 6| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 0| 3| 6| 3| 9| 0| 3| 3| 0| 3| 5| 3| 3| 7| 9| 5| 3| 1| 5| 3| 3| 0| 3|             
                                           | 0| 7| 6| 2| 7| 3| 5| 1| 3| 3| 9| 3| 7| 3| 7| 7| 3| 0| 3| 9| 7| 3| 3| 6| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X        X  X  X  X  X        X     X  X  X  X  X           X   |             
      Lymphoma Malignant                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                          X     X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                  X                    X                  |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Keratoacanthoma                      |                   X                                                      |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Squamous Cell Papilloma              |                                                                      X   |             
      Trichoepithelioma                    |                         X                                                |             
      Sebaceous Gland, Adenoma             |                                                                          |             
      Sebaceous Gland, Carcinoma           |                      X                                                   |             
      Subcutaneous Tissue, Fibroma         |          X                                                               |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 6| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 0| 3| 6| 3| 9| 0| 3| 3| 0| 3| 5| 3| 3| 7| 9| 5| 3| 1| 5| 3| 3| 0| 3|             
                                           | 0| 7| 6| 2| 7| 3| 5| 1| 3| 3| 9| 3| 7| 3| 7| 7| 3| 0| 3| 9| 7| 3| 3| 6| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                            X     X     X           X                     |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 | X     X                       X              X                           |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X                    X  X              X                           |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________|__________________________________________________________________________              
                                           | 5| 3| 7| 6| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 0| 3| 6| 3| 9| 0| 3| 3| 0| 3| 5| 3| 3| 7| 9| 5| 3| 1| 5| 3| 3| 0| 3|             
                                           | 0| 7| 6| 2| 7| 3| 5| 1| 3| 3| 9| 3| 7| 3| 7| 7| 3| 0| 3| 9| 7| 3| 3| 6| 3|             
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________              
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 | X     X  X  X     X  X  X  X  X        X  X  X  X  X  X  X           X   |             
      Lymphoma Malignant                   |                                                                          |             
      Mesothelioma Malignant               |                      X                                                   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 6| 7| 7| 6| 7| 6| 7| 6| 6| 3| 6| 6| 7| 3| 7| 6| 6| 3| 6| 7| 3| 6|             
                             DAY ON TEST   | 5| 3| 1| 2| 3| 1| 5| 3| 3| 3| 8| 9| 5| 2| 2| 3| 5| 0| 0| 2| 5| 3| 3| 5| 5|             
                                           | 7| 3| 9| 8| 3| 6| 6| 3| 2| 3| 8| 5| 7| 1| 3| 3| 7| 2| 0| 2| 7| 8| 3| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                      X                                                   |             
      Leukemia Mononuclear                 |       X     X  X        X     X  X     X  X  X     X  X  X     X  X      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +                    +     +              +     +        +      |             
      Lipoma                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 6| 7| 7| 6| 7| 6| 7| 6| 6| 3| 6| 6| 7| 3| 7| 6| 6| 3| 6| 7| 3| 6|             
                             DAY ON TEST   | 5| 3| 1| 2| 3| 1| 5| 3| 3| 3| 8| 9| 5| 2| 2| 3| 5| 0| 0| 2| 5| 3| 3| 5| 5|             
                                           | 7| 3| 9| 8| 3| 6| 6| 3| 2| 3| 8| 5| 7| 1| 3| 3| 7| 2| 0| 2| 7| 8| 3| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Schwannoma Malignant                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X              X                    X           X         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X  X        X         |             
      Pheochromocytoma Malignant           |                                                                   X      |             
      Pheochromocytoma Benign              |                X     X  X                                                |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X  X                                                         |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                      X                  |             
      Pars Distalis, Adenoma               |          X  X              X     X     X  X           X              X  X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                            X                       X              X      |             
      C-Cell, Adenoma, Multiple            |                                                       X                  |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                   +                                                      |             
      Mesothelioma Malignant               |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 6| 7| 7| 6| 7| 6| 7| 6| 6| 3| 6| 6| 7| 3| 7| 6| 6| 3| 6| 7| 3| 6|             
                             DAY ON TEST   | 5| 3| 1| 2| 3| 1| 5| 3| 3| 3| 8| 9| 5| 2| 2| 3| 5| 0| 0| 2| 5| 3| 3| 5| 5|             
                                           | 7| 3| 9| 8| 3| 6| 6| 3| 2| 3| 8| 5| 7| 1| 3| 3| 7| 2| 0| 2| 7| 8| 3| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                         X         |             
      Carcinoma                            |             X                 X                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|    X           X  X     X     X  X           X     X     X     X  X      |             
      Interstitial Cell, Adenoma           |             X              X                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X  X              X  X     X     X     X  X  X     X  X      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +           +  +  +  +  +     +     +  +           +  +  +     +         |             
      Leukemia Mononuclear                 |                X                                               X         |             
      Deep Cervical, Leukemia Mononuclear  |                                                                X         |             
      Iliac, Leukemia Mononuclear          |                X                                   X                     |             
      Mediastinal, Leukemia Mononuclear    |                X              X                    X  X  X     X         |             
      Pancreatic, Leukemia Mononuclear     |                X        X              X              X  X     X         |             
      Renal, Leukemia Mononuclear          |             X                                      X           X         |             
      Renal, Pheochromocytoma Malignant,   |                                                                          |             
           Metastatic, Adrenal Medulla     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X  X        X     X  X           X     X     X     X  X      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X                 X     X           X  X  X     X         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 6| 7| 7| 6| 7| 6| 7| 6| 6| 3| 6| 6| 7| 3| 7| 6| 6| 3| 6| 7| 3| 6|             
                             DAY ON TEST   | 5| 3| 1| 2| 3| 1| 5| 3| 3| 3| 8| 9| 5| 2| 2| 3| 5| 0| 0| 2| 5| 3| 3| 5| 5|             
                                           | 7| 3| 9| 8| 3| 6| 6| 3| 2| 3| 8| 5| 7| 1| 3| 3| 7| 2| 0| 2| 7| 8| 3| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +                                   +                                    |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X  X        X  X  X  X     X  X  X     X  X  X     X  X      |             
      Lymphoma Malignant                   |                         X                                                |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                X                                                         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                  X                                       |             
      Keratoacanthoma                      |          X  X     X     X     X                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                      X                                                   |             
      Trichoepithelioma                    |                                                                          |             
      Sebaceous Gland, Adenoma             |                                              X                           |             
      Sebaceous Gland, Carcinoma           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                      X  X                                                |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 6| 7| 7| 6| 7| 6| 7| 6| 6| 3| 6| 6| 7| 3| 7| 6| 6| 3| 6| 7| 3| 6|             
                             DAY ON TEST   | 5| 3| 1| 2| 3| 1| 5| 3| 3| 3| 8| 9| 5| 2| 2| 3| 5| 0| 0| 2| 5| 3| 3| 5| 5|             
                                           | 7| 3| 9| 8| 3| 6| 6| 3| 2| 3| 8| 5| 7| 1| 3| 3| 7| 2| 0| 2| 7| 8| 3| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                        +                                 |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X  X                          X                           |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |       X        X                 X           X     X           X         |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X              X        X     X     X  X        X         |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________|__________________________________________________________________________              
                                           | 3| 7| 6| 6| 7| 7| 6| 7| 6| 7| 6| 6| 3| 6| 6| 7| 3| 7| 6| 6| 3| 6| 7| 3| 6|             
                             DAY ON TEST   | 5| 3| 1| 2| 3| 1| 5| 3| 3| 3| 8| 9| 5| 2| 2| 3| 5| 0| 0| 2| 5| 3| 3| 5| 5|             
                                           | 7| 3| 9| 8| 3| 6| 6| 3| 2| 3| 8| 5| 7| 1| 3| 3| 7| 2| 0| 2| 7| 8| 3| 7| 6|             
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________              
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |       X     X  X        X  X  X  X     X  X  X     X  X  X     X  X      |             
      Lymphoma Malignant                   |                         X                                                |             
      Mesothelioma Malignant               |                   X                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 5| 7| 7| 3| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 8| 9| 3| 3| 5| 1| 3| 3|                                            |            |
                                           | 7| 2| 1| 0| 3| 3| 7| 5| 4| 4|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                X                                                         |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X        X     X                                                   |         34 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +                 +  +                                             |  12        |
      Lipoma                               |                            X                                             |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 5| 7| 7| 3| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 8| 9| 3| 3| 5| 1| 3| 3|                                            |            |
                                           | 7| 2| 1| 0| 3| 3| 7| 5| 4| 4|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                         +                                                |   1        |
      Squamous Cell Papilloma              |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X                                                                     |         10 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Pheochromocytoma Malignant           |                            X                                             |          4 |
      Pheochromocytoma Benign              |             X        X                                                   |          7 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |             X              X                                             |          4 |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pars Distalis, Adenoma               |                X        X                                                |         21 |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 5| 7| 7| 3| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 8| 9| 3| 3| 5| 1| 3| 3|                                            |            |
                                           | 7| 2| 1| 0| 3| 3| 7| 5| 4| 4|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Adenoma                      |          X                                                               |          5 |
      C-Cell, Adenoma, Multiple            |                                                                          |          1 |
      Follicular Cell, Carcinoma           |             X                                                            |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   2        |
      Mesothelioma Malignant               |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenoma                              |                            X                                             |          5 |
      Carcinoma                            |                                                                          |          5 |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma|    X     X     X        X  X                                             |         30 |
      Interstitial Cell, Adenoma           |       X     X        X                                                   |          9 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X                 X     X                                             |         27 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 5| 7| 7| 3| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 8| 9| 3| 3| 5| 1| 3| 3|                                            |            |
                                           | 7| 2| 1| 0| 3| 3| 7| 5| 4| 4|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  22        |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          4 |
      Iliac, Leukemia Mononuclear          |                                                                          |          4 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |         13 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |         11 |
      Renal, Leukemia Mononuclear          |                                                                          |          4 |
      Renal, Pheochromocytoma Malignant,   |                                                                          |            |
           Metastatic, Adrenal Medulla     |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X  X              X                                                   |         24 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X                 X                                                   |         18 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X  X        X     X     X                                             |         35 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Fibroadenoma                         |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 5| 7| 7| 3| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 8| 9| 3| 3| 5| 1| 3| 3|                                            |            |
                                           | 7| 2| 1| 0| 3| 3| 7| 5| 4| 4|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Keratoacanthoma                      |                X                                                         |          7 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Papilloma              |    X                                                                     |          3 |
      Trichoepithelioma                    |                                                                          |          1 |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
      Sebaceous Gland, Carcinoma           |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          3 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Osteosarcoma                         |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangioma                           |             X                                                            |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 5| 7| 7| 3| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 8| 9| 3| 3| 5| 1| 3| 3|                                            |            |
                                           | 7| 2| 1| 0| 3| 3| 7| 5| 4| 4|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          7 |
      Alveolar/Bronchiolar Carcinoma       |                            X                                             |          1 |
      Leukemia Mononuclear                 |                      X                                                   |         11 |
      Osteosarcoma, Metastatic, Bone       |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                      X                                                   |         14 |
      Osteosarcoma, Metastatic, Bone       |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X  X        X     X     X                                             |         37 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 5| 7| 6| 7| 7| 3| 5| 3| 7| 5| 5| 5| 3| 7| 7| 7| 7| 7| 7| 3| 7| 3|             
                             DAY ON TEST   | 5| 1| 5| 5| 3| 4| 3| 3| 5| 0| 5| 3| 4| 9| 0| 5| 3| 2| 3| 1| 3| 3| 5| 1| 5|             
                                           | 8| 1| 7| 8| 3| 2| 3| 3| 7| 9| 7| 3| 6| 3| 9| 7| 3| 7| 3| 9| 3| 3| 7| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.05%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 | X  X     X                 X        X  X  X        X           X     X   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +                    +     +  +                 +   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +                                                                        |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              | X                                                                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                         X                     |             
      Acinar Cell, Adenoma                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                X         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 5| 7| 6| 7| 7| 3| 5| 3| 7| 5| 5| 5| 3| 7| 7| 7| 7| 7| 7| 3| 7| 3|             
                             DAY ON TEST   | 5| 1| 5| 5| 3| 4| 3| 3| 5| 0| 5| 3| 4| 9| 0| 5| 3| 2| 3| 1| 3| 3| 5| 1| 5|             
                                           | 8| 1| 7| 8| 3| 2| 3| 3| 7| 9| 7| 3| 6| 3| 9| 7| 3| 7| 3| 9| 3| 3| 7| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.05%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X                 X                       X                     |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X                                X              X                     |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X                                                  X                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Pars Distalis, Adenoma               |             X  X                                                         |             
      Pars Distalis, Adenoma, Multiple     |                                                 X                        |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 5| 7| 6| 7| 7| 3| 5| 3| 7| 5| 5| 5| 3| 7| 7| 7| 7| 7| 7| 3| 7| 3|             
                             DAY ON TEST   | 5| 1| 5| 5| 3| 4| 3| 3| 5| 0| 5| 3| 4| 9| 0| 5| 3| 2| 3| 1| 3| 3| 5| 1| 5|             
                                           | 8| 1| 7| 8| 3| 2| 3| 3| 7| 9| 7| 3| 6| 3| 9| 7| 3| 7| 3| 9| 3| 3| 7| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.05%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      Follicular Cell, Carcinoma           |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                    +                     |             
      Mesothelioma Malignant               |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                 X  X                     |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                            X                                             |             
      Leukemia Mononuclear                 |          X                                                               |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X              X  X     X     X  X  X        X  X  X     X  X     X   |             
      Interstitial Cell, Adenoma           |             X           X     X           X              X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X                 X        X  X  X        X                 X   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 5| 7| 6| 7| 7| 3| 5| 3| 7| 5| 5| 5| 3| 7| 7| 7| 7| 7| 7| 3| 7| 3|             
                             DAY ON TEST   | 5| 1| 5| 5| 3| 4| 3| 3| 5| 0| 5| 3| 4| 9| 0| 5| 3| 2| 3| 1| 3| 3| 5| 1| 5|             
                                           | 8| 1| 7| 8| 3| 2| 3| 3| 7| 9| 7| 3| 6| 3| 9| 7| 3| 7| 3| 9| 3| 3| 7| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.05%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
   Lymph Node                              |    +     +                 +        +  +        +  +        +        +   |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |    X     X                 X        X              X                 X   |             
      Pancreatic, Leukemia Mononuclear     |    X                       X        X              X                     |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X                 X           X                             X   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X                             X  X        X                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X                 X        X  X  X        X           X     X   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                           X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Keratoacanthoma                      | X           X        X                                                   |             
      Squamous Cell Papilloma              |                                                 X                        |             
      Subcutaneous Tissue, Fibroma         |          X                                                               |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 5| 7| 6| 7| 7| 3| 5| 3| 7| 5| 5| 5| 3| 7| 7| 7| 7| 7| 7| 3| 7| 3|             
                             DAY ON TEST   | 5| 1| 5| 5| 3| 4| 3| 3| 5| 0| 5| 3| 4| 9| 0| 5| 3| 2| 3| 1| 3| 3| 5| 1| 5|             
                                           | 8| 1| 7| 8| 3| 2| 3| 3| 7| 9| 7| 3| 6| 3| 9| 7| 3| 7| 3| 9| 3| 3| 7| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.05%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                          +               |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                          +               |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |          X                                                               |             
      Leukemia Mononuclear                 | X  X     X                 X           X  X                              |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X                                                           X   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 5| 7| 6| 7| 7| 3| 5| 3| 7| 5| 5| 5| 3| 7| 7| 7| 7| 7| 7| 3| 7| 3|             
                             DAY ON TEST   | 5| 1| 5| 5| 3| 4| 3| 3| 5| 0| 5| 3| 4| 9| 0| 5| 3| 2| 3| 1| 3| 3| 5| 1| 5|             
                                           | 8| 1| 7| 8| 3| 2| 3| 3| 7| 9| 7| 3| 6| 3| 9| 7| 3| 7| 3| 9| 3| 3| 7| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.05%                                  | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X                 X        X  X  X        X           X     X   |             
      Mesothelioma Malignant               |                                                 X  X                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 5| 5| 7| 6| 7| 7| 5| 7| 5| 7| 2| 3| 6| 5| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 7| 3| 9| 7| 5| 3| 2| 3| 2| 6| 1| 7| 3| 2| 5| 5| 4| 3| 8| 3| 2| 3| 1|             
                                           | 2| 8| 7| 3| 5| 5| 8| 3| 8| 3| 6| 0| 9| 0| 3| 2| 7| 6| 5| 3| 6| 3| 8| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.05%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                           X        X                     |             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X     X  X  X  X  X  X  X  X     X  X  X  X  X     X  X|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +        +              +           +                    +               |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                         +|             
      Squamous Cell Carcinoma              |                                                                         X|             
      Squamous Cell Papilloma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X                                                               |             
      Acinar Cell, Adenoma                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Squamous Cell Papilloma              |                                                                         X|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 5| 5| 7| 6| 7| 7| 5| 7| 5| 7| 2| 3| 6| 5| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 7| 3| 9| 7| 5| 3| 2| 3| 2| 6| 1| 7| 3| 2| 5| 5| 4| 3| 8| 3| 2| 3| 1|             
                                           | 2| 8| 7| 3| 5| 5| 8| 3| 8| 3| 6| 0| 9| 0| 3| 2| 7| 6| 5| 3| 6| 3| 8| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.05%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                                                          X               |             
      Leukemia Mononuclear                 |                                                             X            |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X     X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X     X           X              X     X        X     X            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X           X                    X        X                           |             
      Pheochromocytoma Malignant           |                                                          X               |             
      Pheochromocytoma Benign              | X           X                    X                             X  X     X|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                             X            |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pars Distalis, Adenoma               | X                             X                             X            |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Intermedia, Adenoma             |                                                                      X   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 5| 5| 7| 6| 7| 7| 5| 7| 5| 7| 2| 3| 6| 5| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 7| 3| 9| 7| 5| 3| 2| 3| 2| 6| 1| 7| 3| 2| 5| 5| 4| 3| 8| 3| 2| 3| 1|             
                                           | 2| 8| 7| 3| 5| 5| 8| 3| 8| 3| 6| 0| 9| 0| 3| 2| 7| 6| 5| 3| 6| 3| 8| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.05%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                X           X                                             |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
      Carcinoma                            |    X  X                                                                  |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X  X  X  X  X     X  X           X  X  X              X     X  X  X  X|             
      Interstitial Cell, Adenoma           | X                 X        X  X  X              X  X  X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X  X  X        X        X  X  X  X  X        X  X  X           X|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 5| 5| 7| 6| 7| 7| 5| 7| 5| 7| 2| 3| 6| 5| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 7| 3| 9| 7| 5| 3| 2| 3| 2| 6| 1| 7| 3| 2| 5| 5| 4| 3| 8| 3| 2| 3| 1|             
                                           | 2| 8| 7| 3| 5| 5| 8| 3| 8| 3| 6| 0| 9| 0| 3| 2| 7| 6| 5| 3| 6| 3| 8| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.05%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
   Lymph Node                              | +     +  +  +           +        +  +        +  +     +  +              +|             
      Deep Cervical, Leukemia Mononuclear  |             X                                                            |             
      Inguinal, Leukemia Mononuclear       |       X                                                                  |             
      Mediastinal, Leukemia Mononuclear    | X     X     X           X        X           X        X                 X|             
      Pancreatic, Leukemia Mononuclear     | X        X  X                    X           X           X               |             
      Renal, Leukemia Mononuclear          |             X                       X                                    |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X  X  X        X        X  X  X  X  X     X  X     X        X  X|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X              X        X  X  X     X     X  X  X              X|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                              +  +                        |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X     X  X     X  X  X  X  X     X  X  X  X  X     X  X|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X                    X  X     X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +|             
      Fibroadenoma                         |                                                          X               |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   | X                                                                        |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                                                                      X   |             
      Subcutaneous Tissue, Fibroma         |                                                                         X|             
      Subcutaneous Tissue, Lipoma          |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 5| 5| 7| 6| 7| 7| 5| 7| 5| 7| 2| 3| 6| 5| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 7| 3| 9| 7| 5| 3| 2| 3| 2| 6| 1| 7| 3| 2| 5| 5| 4| 3| 8| 3| 2| 3| 1|             
                                           | 2| 8| 7| 3| 5| 5| 8| 3| 8| 3| 6| 0| 9| 0| 3| 2| 7| 6| 5| 3| 6| 3| 8| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.05%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X     X                           |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                        +                                 |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                        +                                 |             
      Leukemia Mononuclear                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                           X                              |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |             X  X        X        X  X  X     X     X  X                  |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X           X           X  X     X     X                     |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 5| 5| 7| 6| 7| 7| 5| 7| 5| 7| 2| 3| 6| 5| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 7| 3| 9| 7| 5| 3| 2| 3| 2| 6| 1| 7| 3| 2| 5| 5| 4| 3| 8| 3| 2| 3| 1|             
                                           | 2| 8| 7| 3| 5| 5| 8| 3| 8| 3| 6| 0| 9| 0| 3| 2| 7| 6| 5| 3| 6| 3| 8| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.05%                                  | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X     X  X  X  X  X  X  X  X     X  X  X  X  X     X  X|             
      Mesothelioma Malignant               |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 6| 5| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 0| 1| 5| 3| 5|                                            |            |
                                           | 7| 3| 3| 3| 4| 2| 0| 7| 4| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.05%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  M                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Leukemia Mononuclear                 |             X              X                                             |         34 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |             +              +                                             |  12        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                            X                                             |          5 |
      Acinar Cell, Adenoma                 |       X                                                                  |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 6| 5| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 0| 1| 5| 3| 5|                                            |            |
                                           | 7| 3| 3| 3| 4| 2| 0| 7| 4| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.05%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +                                                                        |   1        |
      Squamous Cell Carcinoma              | X                                                                        |          1 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |         14 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                            X                                             |         10 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          8 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                X                                                         |          3 |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 6| 5| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 0| 1| 5| 3| 5|                                            |            |
                                           | 7| 3| 3| 3| 4| 2| 0| 7| 4| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.05%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               |                X        X                                                |          7 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          2 |
      C-Cell, Adenoma, Multiple            |          X                                                               |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
      Mesothelioma Malignant               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                   X     X                                                |          4 |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenocarcinoma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 6| 5| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 0| 1| 5| 3| 5|                                            |            |
                                           | 7| 3| 3| 3| 4| 2| 0| 7| 4| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.05%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bilateral, Interstitial Cell, Adenoma|    X  X  X  X     X     X  X                                             |         36 |
      Interstitial Cell, Adenoma           |                                                                          |         13 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |             X              X                                             |         26 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +              +  +  +                                             |  25        |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                            X                                             |         15 |
      Pancreatic, Leukemia Mononuclear     |                            X                                             |         11 |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |       X     X                                                            |         23 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |             X                                                            |         20 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                      +                                                   |   3        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X  X     X              X                                             |         35 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 |                            X                                             |          8 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 6| 5| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 0| 1| 5| 3| 5|                                            |            |
                                           | 7| 3| 3| 3| 4| 2| 0| 7| 4| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.05%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Fibroadenoma                         |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Keratoacanthoma                      |       X                                                                  |          4 |
      Squamous Cell Papilloma              |             X                                                            |          3 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |          1 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 6| 5| 3| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 0| 1| 5| 3| 5|                                            |            |
                                           | 7| 3| 3| 3| 4| 2| 0| 7| 4| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.05%                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 |             X              X                                             |         17 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                            X                                             |         12 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |    X  X     X              X                                             |         36 |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 3| 7| 4| 6| 6| 7| 7| 6| 3| 6| 6| 3| 6| 7| 6| 4| 7| 3| 6| 3| 6| 5|             
                             DAY ON TEST   | 3| 5| 2| 5| 3| 9| 9| 4| 3| 1| 6| 5| 8| 4| 5| 1| 3| 5| 5| 1| 5| 8| 5| 9| 5|             
                                           | 3| 7| 7| 7| 3| 1| 9| 9| 3| 4| 3| 7| 6| 9| 7| 0| 3| 9| 3| 2| 7| 6| 7| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.17%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Adenomatous                    |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |             X                 X                    X  X  X     X     X   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                         +     +                             +  +         |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +                                                                  |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinar Cell, Adenoma                 |                                        X                             X   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 3| 7| 4| 6| 6| 7| 7| 6| 3| 6| 6| 3| 6| 7| 6| 4| 7| 3| 6| 3| 6| 5|             
                             DAY ON TEST   | 3| 5| 2| 5| 3| 9| 9| 4| 3| 1| 6| 5| 8| 4| 5| 1| 3| 5| 5| 1| 5| 8| 5| 9| 5|             
                                           | 3| 7| 7| 7| 3| 1| 9| 9| 3| 4| 3| 7| 6| 9| 7| 0| 3| 9| 3| 2| 7| 6| 7| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.17%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                +         |             
      Squamous Cell Papilloma              |                                                                X         |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                    X  X                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
      Neuroblastoma                        |                                                                          |             
      Pheochromocytoma Malignant           |                                                          X               |             
      Pheochromocytoma Benign              |                   X  X     X                       X                    X|             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            | X                                                                        |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |             X        X                 X                       X         |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 3| 7| 4| 6| 6| 7| 7| 6| 3| 6| 6| 3| 6| 7| 6| 4| 7| 3| 6| 3| 6| 5|             
                             DAY ON TEST   | 3| 5| 2| 5| 3| 9| 9| 4| 3| 1| 6| 5| 8| 4| 5| 1| 3| 5| 5| 1| 5| 8| 5| 9| 5|             
                                           | 3| 7| 7| 7| 3| 1| 9| 9| 3| 4| 3| 7| 6| 9| 7| 0| 3| 9| 3| 2| 7| 6| 7| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.17%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                              X                           |             
      C-Cell, Carcinoma                    |             X                                                            |             
      Follicular Cell, Adenoma             |                                                    X                     |             
      Follicular Cell, Carcinoma           |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                +                                                         |             
      Mesothelioma Malignant               |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X     X        X  X  X  X  X  X     X  X     X  X  X     X     X     X  X|             
      Interstitial Cell, Adenoma           |             X                    X                    X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                    X  X        X     X   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +        +     +     +  +                    +  +     +        +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                      X   |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 3| 7| 4| 6| 6| 7| 7| 6| 3| 6| 6| 3| 6| 7| 6| 4| 7| 3| 6| 3| 6| 5|             
                             DAY ON TEST   | 3| 5| 2| 5| 3| 9| 9| 4| 3| 1| 6| 5| 8| 4| 5| 1| 3| 5| 5| 1| 5| 8| 5| 9| 5|             
                                           | 3| 7| 7| 7| 3| 1| 9| 9| 3| 4| 3| 7| 6| 9| 7| 0| 3| 9| 3| 2| 7| 6| 7| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.17%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                               X                    X  X              X   |             
      Pancreatic, Leukemia Mononuclear     |                                                    X  X                  |             
      Renal, Leukemia Mononuclear          |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |             X                 X                    X  X                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                      X                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +                                                        +            |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                 X                        |             
      Leukemia Mononuclear                 |             X                 X                    X  X        X     X   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
      Fibroadenoma                         | X                       X                                                |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Basal Cell Carcinoma                 |             X                                                            |             
      Keratoacanthoma                      |                                                          X               |             
      Squamous Cell Papilloma              |                                                                X         |             
      Subcutaneous Tissue, Fibroma         |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 3| 7| 4| 6| 6| 7| 7| 6| 3| 6| 6| 3| 6| 7| 6| 4| 7| 3| 6| 3| 6| 5|             
                             DAY ON TEST   | 3| 5| 2| 5| 3| 9| 9| 4| 3| 1| 6| 5| 8| 4| 5| 1| 3| 5| 5| 1| 5| 8| 5| 9| 5|             
                                           | 3| 7| 7| 7| 3| 1| 9| 9| 3| 4| 3| 7| 6| 9| 7| 0| 3| 9| 3| 2| 7| 6| 7| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.17%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
   Skeletal Muscle                         |                            +                                            +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                       X                  |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |                               X                    X  X                  |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                    X                     |             
      Renal Tubule, Carcinoma              |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 3| 7| 4| 6| 6| 7| 7| 6| 3| 6| 6| 3| 6| 7| 6| 4| 7| 3| 6| 3| 6| 5|             
                             DAY ON TEST   | 3| 5| 2| 5| 3| 9| 9| 4| 3| 1| 6| 5| 8| 4| 5| 1| 3| 5| 5| 1| 5| 8| 5| 9| 5|             
                                           | 3| 7| 7| 7| 3| 1| 9| 9| 3| 4| 3| 7| 6| 9| 7| 0| 3| 9| 3| 2| 7| 6| 7| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.17%                                  | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X                    X  X  X     X     X   |             
      Mesothelioma Malignant               |                X                                                         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 6| 7| 6| 6| 6| 3| 4| 3| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 7| 4|             
                             DAY ON TEST   | 0| 4| 8| 3| 3| 6| 1| 8| 8| 6| 5| 6| 5| 9| 3| 5| 1| 0| 3| 4| 0| 9| 3| 0| 0|             
                                           | 0| 6| 0| 3| 3| 3| 9| 6| 6| 7| 7| 8| 7| 5| 3| 0| 5| 0| 3| 6| 7| 2| 1| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.17%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Adenomatous                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                             X            |             
      Leukemia Mononuclear                 |    X  X     X  X                 X              X  X     X  X  X  X      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +        +              +                    +  +                     |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +                                                                 +|             
      Squamous Cell Carcinoma              |       X                                                                  |             
      Squamous Cell Papilloma              |                                                                         X|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
      Acinar Cell, Adenoma                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 6| 7| 6| 6| 6| 3| 4| 3| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 7| 4|             
                             DAY ON TEST   | 0| 4| 8| 3| 3| 6| 1| 8| 8| 6| 5| 6| 5| 9| 3| 5| 1| 0| 3| 4| 0| 9| 3| 0| 0|             
                                           | 0| 6| 0| 3| 3| 3| 9| 6| 6| 7| 7| 8| 7| 5| 3| 0| 5| 0| 3| 6| 7| 2| 1| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.17%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |       +                 +                                            +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                     X        X      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X  X     X               |             
      Neuroblastoma                        |                                                                          |             
      Pheochromocytoma Malignant           |          X                                                               |             
      Pheochromocytoma Benign              |                   X     X                             X        X         |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X           X              X              X              X               |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Intermedia, Adenoma             |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 6| 7| 6| 6| 6| 3| 4| 3| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 7| 4|             
                             DAY ON TEST   | 0| 4| 8| 3| 3| 6| 1| 8| 8| 6| 5| 6| 5| 9| 3| 5| 1| 0| 3| 4| 0| 9| 3| 0| 0|             
                                           | 0| 6| 0| 3| 3| 3| 9| 6| 6| 7| 7| 8| 7| 5| 3| 0| 5| 0| 3| 6| 7| 2| 1| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.17%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                      X  X                                                |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +     +                                                                  |             
      Mesothelioma Malignant               | X     X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               | X     X                                                                  |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X        X  X  X  X           X  X  X  X  X  X     X  X  X  X   |             
      Interstitial Cell, Adenoma           |             X  X                 X                       X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                 X              X  X     X  X     X      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +     +        +  +  +  +        +  +  +  +              +     +  +     +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Deep Cervical, Leukemia Mononuclear  |                                                          X               |             
      Iliac, Leukemia Mononuclear          |                                  X                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 6| 7| 6| 6| 6| 3| 4| 3| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 7| 4|             
                             DAY ON TEST   | 0| 4| 8| 3| 3| 6| 1| 8| 8| 6| 5| 6| 5| 9| 3| 5| 1| 0| 3| 4| 0| 9| 3| 0| 0|             
                                           | 0| 6| 0| 3| 3| 3| 9| 6| 6| 7| 7| 8| 7| 5| 3| 0| 5| 0| 3| 6| 7| 2| 1| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.17%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                X                 X                       X        X      |             
      Pancreatic, Leukemia Mononuclear     |                                  X                       X        X      |             
      Renal, Leukemia Mononuclear          |                                  X                       X     X         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |                X                 X              X  X     X     X  X      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                 X              X  X     X        X      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                     +                                    |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 |    X  X     X  X                 X              X  X     X  X  X  X      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X              X        X        X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                X         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                        X                                 |             
      Basal Cell Carcinoma                 |    X                                                                     |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                   X                                                      |             
      Subcutaneous Tissue, Fibroma         |                X                          X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 6| 7| 6| 6| 6| 3| 4| 3| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 7| 4|             
                             DAY ON TEST   | 0| 4| 8| 3| 3| 6| 1| 8| 8| 6| 5| 6| 5| 9| 3| 5| 1| 0| 3| 4| 0| 9| 3| 0| 0|             
                                           | 0| 6| 0| 3| 3| 3| 9| 6| 6| 7| 7| 8| 7| 5| 3| 0| 5| 0| 3| 6| 7| 2| 1| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.17%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
   Skeletal Muscle                         | +                                                                 +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                +         |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                      X   |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |    X                             X              X        X        X      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                         M                                                |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                             X                                X      |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                +                                                         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 6| 7| 6| 6| 6| 3| 4| 3| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 7| 4|             
                             DAY ON TEST   | 0| 4| 8| 3| 3| 6| 1| 8| 8| 6| 5| 6| 5| 9| 3| 5| 1| 0| 3| 4| 0| 9| 3| 0| 0|             
                                           | 0| 6| 0| 3| 3| 3| 9| 6| 6| 7| 7| 8| 7| 5| 3| 0| 5| 0| 3| 6| 7| 2| 1| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.17%                                  | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X     X  X                 X              X  X     X  X  X  X      |             
      Mesothelioma Malignant               | X     X                                                                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 6| 2| 6| 6| 5| 3| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 9| 4| 4| 7| 9| 0| 8| 9|                                            |            |
                                           | 0| 7| 0| 9| 6| 2| 5| 2| 4| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.17%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  +  +  +  +  +  +  +  M                                             |  58        |
      Polyp Adenomatous                    |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X                                                               |         20 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |  10        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   3        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Acinar Cell, Adenoma                 |                X  X                                                      |          4 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Carcinoma, Metastatic, Zymbal's Gland|                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 6| 2| 6| 6| 5| 3| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 9| 4| 4| 7| 9| 0| 8| 9|                                            |            |
                                           | 0| 7| 0| 9| 6| 2| 5| 2| 4| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.17%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |          X                                                               |          7 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |       X                                                                  |          5 |
      Neuroblastoma                        |       X                                                                  |          1 |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |                      X     X                                             |         11 |
      Bilateral, Pheochromocytoma Benign   |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  57        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 6| 2| 6| 6| 5| 3| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 9| 4| 4| 7| 9| 0| 8| 9|                                            |            |
                                           | 0| 7| 0| 9| 6| 2| 5| 2| 4| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.17%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
      Pars Distalis, Adenoma               | X        X     X     X                                                   |         13 |
      Pars Distalis, Adenoma, Multiple     |                   X                                                      |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      C-Cell, Adenoma                      |                                                                          |          3 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   3        |
      Mesothelioma Malignant               |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            | X                                                                        |          1 |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mesothelioma Malignant               |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 117                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 6| 2| 6| 6| 5| 3| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 9| 4| 4| 7| 9| 0| 8| 9|                                            |            |
                                           | 0| 7| 0| 9| 6| 2| 5| 2| 4| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.17%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Interstitial Cell, Adenoma| X     X  X     X  X  X     X                                             |         42 |
      Interstitial Cell, Adenoma           |                                                                          |          7 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |       X  X                                                               |         14 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +           +                                                   |  30        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          2 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |       X  X                                                               |         10 |
      Pancreatic, Leukemia Mononuclear     |          X                                                               |          6 |
      Renal, Leukemia Mononuclear          |                                                                          |          4 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Carcinoma, Metastatic, Zymbal's Gland|                         X                                                |          1 |
      Leukemia Mononuclear                 |       X  X                                                               |         13 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +                                                                     |   4        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X                                                               |         19 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 |       X  X                                                               |          7 |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 118                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 6| 2| 6| 6| 5| 3| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 9| 4| 4| 7| 9| 0| 8| 9|                                            |            |
                                           | 0| 7| 0| 9| 6| 2| 5| 2| 4| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.17%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Fibroadenoma                         |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basal Cell Adenoma                   |       X                                                                  |          2 |
      Basal Cell Carcinoma                 |                                                                          |          2 |
      Keratoacanthoma                      | X                                                                        |          2 |
      Squamous Cell Papilloma              |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Carcinoma, Metastatic, Zymbal's Gland|                         X                                                |          1 |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 119                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 6| 2| 6| 6| 5| 3| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 9| 4| 4| 7| 9| 0| 8| 9|                                            |            |
                                           | 0| 7| 0| 9| 6| 2| 5| 2| 4| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.17%                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                +                                                         |   1        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                         +                                                |   1        |
      Carcinoma                            |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |          X                                                               |          6 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |       X  X                                                               |         20 |
      Mesothelioma Malignant               |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 120                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 3| 5| 5| 4| 4| 5| 6| 6| 3| 5| 5| 6| 4| 5| 3| 3| 6| 7| 4| 3| 4| 6| 7|             
                             DAY ON TEST   | 5| 3| 5| 7| 9| 9| 9| 9| 2| 2| 5| 4| 6| 9| 9| 6| 2| 4| 5| 3| 9| 5| 9| 1| 1|             
                                           | 7| 4| 7| 2| 6| 8| 2| 6| 4| 4| 7| 6| 6| 5| 8| 8| 0| 5| 6| 3| 6| 7| 8| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                         X                                                |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                   X     X|             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Leukemia Mononuclear                 |             X        X              X        X        X           X      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +                             +                              |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                        +                                 |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinar Cell, Adenoma                 |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 121                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 3| 5| 5| 4| 4| 5| 6| 6| 3| 5| 5| 6| 4| 5| 3| 3| 6| 7| 4| 3| 4| 6| 7|             
                             DAY ON TEST   | 5| 3| 5| 7| 9| 9| 9| 9| 2| 2| 5| 4| 6| 9| 9| 6| 2| 4| 5| 3| 9| 5| 9| 1| 1|             
                                           | 7| 4| 7| 2| 6| 8| 2| 6| 4| 4| 7| 6| 6| 5| 8| 8| 0| 5| 6| 3| 6| 7| 8| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  |                            +                                            +|             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                       X        X                           |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                            X           X                          X      |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |          X              X              X                             X   |             
      Pars Distalis, Adenoma, Multiple     |                                     X                                    |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                           X                              |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |             X        X                                                   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 122                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 3| 5| 5| 4| 4| 5| 6| 6| 3| 5| 5| 6| 4| 5| 3| 3| 6| 7| 4| 3| 4| 6| 7|             
                             DAY ON TEST   | 5| 3| 5| 7| 9| 9| 9| 9| 2| 2| 5| 4| 6| 9| 9| 6| 2| 4| 5| 3| 9| 5| 9| 1| 1|             
                                           | 7| 4| 7| 2| 6| 8| 2| 6| 4| 4| 7| 6| 6| 5| 8| 8| 0| 5| 6| 3| 6| 7| 8| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                             +            |             
      Mesothelioma Malignant               |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                              X                           |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                              X                           |             
      Bilateral, Interstitial Cell, Adenoma|    X        X  X  X  X     X     X  X  X  X  X        X  X  X     X  X  X|             
      Interstitial Cell, Adenoma           |          X              X                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X              X        X        X                  |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +  +        +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                     X                 X                  |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |             X                       X        X        X                  |             
      Pancreatic, Leukemia Mononuclear     |                                     X        X                           |             
      Renal, Leukemia Mononuclear          |                                              X        X                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X              X        X        X                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 123                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 3| 5| 5| 4| 4| 5| 6| 6| 3| 5| 5| 6| 4| 5| 3| 3| 6| 7| 4| 3| 4| 6| 7|             
                             DAY ON TEST   | 5| 3| 5| 7| 9| 9| 9| 9| 2| 2| 5| 4| 6| 9| 9| 6| 2| 4| 5| 3| 9| 5| 9| 1| 1|             
                                           | 7| 4| 7| 2| 6| 8| 2| 6| 4| 4| 7| 6| 6| 5| 8| 8| 0| 5| 6| 3| 6| 7| 8| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                               +                 +                        |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X              X        X        X           X      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |             X                                                            |             
      Squamous Cell Papilloma              |                            X                                             |             
      Sebaceous Gland, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                +                 +        +        +              +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 124                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 3| 5| 5| 4| 4| 5| 6| 6| 3| 5| 5| 6| 4| 5| 3| 3| 6| 7| 4| 3| 4| 6| 7|             
                             DAY ON TEST   | 5| 3| 5| 7| 9| 9| 9| 9| 2| 2| 5| 4| 6| 9| 9| 6| 2| 4| 5| 3| 9| 5| 9| 1| 1|             
                                           | 7| 4| 7| 2| 6| 8| 2| 6| 4| 4| 7| 6| 6| 5| 8| 8| 0| 5| 6| 3| 6| 7| 8| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |             X                                X                           |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                               +                 +              +         |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                       +                  |             
      Carcinoma                            |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X        X                           |             
      Renal Tubule, Adenoma                |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X              X        X        X           X      |             
      Mesothelioma Malignant               |                                              X              X            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 125                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 6| 3| 7| 6| 6| 6| 7| 4| 6| 5| 7| 7| 4| 7| 5| 3| 5| 5| 3|             
                             DAY ON TEST   | 1| 0| 9| 0| 1| 2| 5| 5| 0| 9| 5| 0| 2| 8| 9| 0| 2| 0| 3| 3| 0| 4| 0| 8| 0|             
                                           | 6| 0| 3| 0| 5| 2| 8| 7| 4| 1| 6| 2| 6| 1| 5| 5| 7| 6| 2| 3| 2| 5| 9| 9| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                 X                        |             
      Leukemia Mononuclear                 |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |    X                                                                     |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |       X                             X                    X               |             
      Hepatocellular Adenoma, Multiple     |                                                    X                     |             
      Leukemia Mononuclear                 | X  X  X     X  X  X     X  X  X     X  X  X        X        X        X   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +  +  +                       +  +              +        +  +         |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                        +                                 |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
      Acinar Cell, Adenoma                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 126                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 6| 3| 7| 6| 6| 6| 7| 4| 6| 5| 7| 7| 4| 7| 5| 3| 5| 5| 3|             
                             DAY ON TEST   | 1| 0| 9| 0| 1| 2| 5| 5| 0| 9| 5| 0| 2| 8| 9| 0| 2| 0| 3| 3| 0| 4| 0| 8| 0|             
                                           | 6| 0| 3| 0| 5| 2| 8| 7| 4| 1| 6| 2| 6| 1| 5| 5| 7| 6| 2| 3| 2| 5| 9| 9| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +                                         +                              |             
      Squamous Cell Papilloma              | X                                         X                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X                                            X            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X           X                                                      |             
      Pheochromocytoma Benign              |       X  X                    X                                          |             
      Bilateral, Pheochromocytoma Benign   |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                X                                            X            |             
      Pars Distalis, Adenoma               |          X                       X                                X      |             
      Pars Distalis, Adenoma, Multiple     |                                                                      X   |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X        X                                                               |             
      C-Cell, Carcinoma                    |                                  X                                       |             
      Follicular Cell, Carcinoma           |                                                 X                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 127                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 6| 3| 7| 6| 6| 6| 7| 4| 6| 5| 7| 7| 4| 7| 5| 3| 5| 5| 3|             
                             DAY ON TEST   | 1| 0| 9| 0| 1| 2| 5| 5| 0| 9| 5| 0| 2| 8| 9| 0| 2| 0| 3| 3| 0| 4| 0| 8| 0|             
                                           | 6| 0| 3| 0| 5| 2| 8| 7| 4| 1| 6| 2| 6| 1| 5| 5| 7| 6| 2| 3| 2| 5| 9| 9| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +                 +                                                      |             
      Mesothelioma Malignant               | X                 X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               | X                 X                                                      |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            | X                                   X                                    |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               | X                 X                                                      |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X     X     X     X     X  X  X  X     X  X            |             
      Interstitial Cell, Adenoma           |                            X           X                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X     X  X  X     X  X  X     X  X  X        X        X        X   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +        +  +  +     +     +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                X                                                     X   |             
      Deep Cervical, Leukemia Mononuclear  |                X              X                                          |             
      Iliac, Leukemia Mononuclear          |    X                                                                     |             
      Inguinal, Leukemia Mononuclear       |                                                                      X   |             
      Mediastinal, Leukemia Mononuclear    | X  X        X  X  X        X           X           X        X        X   |             
      Pancreatic, Leukemia Mononuclear     |    X  X        X  X        X           X                             X   |             
      Renal, Leukemia Mononuclear          |    X           X  X                                X                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 | X  X  X        X  X        X  X     X  X  X        X        X        X   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 128                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 6| 3| 7| 6| 6| 6| 7| 4| 6| 5| 7| 7| 4| 7| 5| 3| 5| 5| 3|             
                             DAY ON TEST   | 1| 0| 9| 0| 1| 2| 5| 5| 0| 9| 5| 0| 2| 8| 9| 0| 2| 0| 3| 3| 0| 4| 0| 8| 0|             
                                           | 6| 0| 3| 0| 5| 2| 8| 7| 4| 1| 6| 2| 6| 1| 5| 5| 7| 6| 2| 3| 2| 5| 9| 9| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X           X        X     X        X  X                 X        X   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                +         |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X     X  X  X     X  X  X     X  X  X        X        X        X   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                         X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                X                                                         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                                                    X     X               |             
      Sebaceous Gland, Carcinoma           |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +        +     +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 129                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 6| 3| 7| 6| 6| 6| 7| 4| 6| 5| 7| 7| 4| 7| 5| 3| 5| 5| 3|             
                             DAY ON TEST   | 1| 0| 9| 0| 1| 2| 5| 5| 0| 9| 5| 0| 2| 8| 9| 0| 2| 0| 3| 3| 0| 4| 0| 8| 0|             
                                           | 6| 0| 3| 0| 5| 2| 8| 7| 4| 1| 6| 2| 6| 1| 5| 5| 7| 6| 2| 3| 2| 5| 9| 9| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Alveolar/Bronchiolar Carcinoma       | X                                                                        |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                           +                              |             
                                           |__________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X  X                                         X            |             
      Renal Tubule, Adenoma                |                X  X                                                      |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X     X  X  X     X  X  X     X  X  X        X        X        X   |             
      Mesothelioma Malignant               | X                 X                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 130                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 5| 5| 6| 6| 6| 5| 6| 3|                                            |            |
                             DAY ON TEST   | 5| 7| 6| 9| 7| 9| 2| 1| 9| 7|                                            |            |
                                           | 7| 8| 3| 0| 8| 5| 9| 0| 0| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0.5%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangioma                           |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Adenoma               |       X                                                                  |          6 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X                                                |         22 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |             +           +  +                                             |  13        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +        +                                                               |   4        |
      Squamous Cell Carcinoma              |          X                                                               |          1 |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Acinar Cell, Adenoma                 |             X                                                            |          2 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 131                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 5| 5| 6| 6| 6| 5| 6| 3|                                            |            |
                             DAY ON TEST   | 5| 7| 6| 9| 7| 9| 2| 1| 9| 7|                                            |            |
                                           | 7| 8| 3| 0| 8| 5| 9| 0| 0| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0.5%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   4        |
      Squamous Cell Papilloma              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                         X                                                |          8 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pheochromocytoma Benign              |                                                                          |          6 |
      Bilateral, Pheochromocytoma Benign   |                         X                                                |          2 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 132                                                               
                                                                                                                                   
NTP Experiment-Test: 05128-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/25/00    
Route: DOSED FEED                                                                                                 Time: 08:27:12    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 5| 5| 6| 6| 6| 5| 6| 3|                                            |            |
                             DAY ON TEST   | 5| 7| 6| 9| 7| 9| 2| 1| 9| 7|                                            |            |
                                           | 7| 8| 3| 0| 8| 5| 9| 0| 0| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0.5%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               |                   X                                                      |          8 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          2 |
      Pars Intermedia, Adenoma             |                X                                                         |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Adenoma                      |                                                                          |          3 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   3        |
      Mesothelioma Malignant               |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mesothelioma Malignant               |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma                            |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +