TDMS Study 05128-06 Pathology Tables
NTP Experiment-Test: 05128-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 04/03/96
Route: DOSED FEED Time: 23:34:28
Facility: Southern Research Institute
Chemical CAS #: 8003-22-3
Lock Date: 01/12/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05128-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 04/03/96
Route: DOSED FEED Time: 23:34:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.05% 0.17% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 9 10 9
Early Deaths
Moribund Sacrifice 25 23 12 25
Natural Death 3 2 1 3
Survivors
Terminal Sacrifice 22 26 37 23
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (58) (59) (60)
Carcinoma 1 (2%) 1 (2%)
Intestine Large, Rectum (59) (59) (59) (59)
Histiocytic Sarcoma 1 (2%)
Intestine Large, Cecum (60) (60) (59) (59)
Intestine Small, Jejunum (59) (60) (60) (60)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (58) (60) (59) (58)
Liver (60) (60) (60) (60)
Cholangiocarcinoma 1 (2%) 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 5 (8%) 4 (7%)
Hepatocellular Adenoma, Multiple 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mesentery (12) (20) (8) (14)
Cholangiocarcinoma, Metastatic, Liver 1 (7%)
Osteosarcoma, Metastatic, Bone 1 (5%)
Oral Mucosa (1) (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%) 1 (100%)
Pancreas (60) (60) (60) (60)
Osteosarcoma, Metastatic, Bone 1 (2%)
Salivary Glands (60) (55) (60) (59)
Stomach, Forestomach (60) (60) (60) (60)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (3%) 2 (3%)
Stomach, Glandular (60) (60) (60) (60)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05128-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 04/03/96
Route: DOSED FEED Time: 23:34:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.05% 0.17% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Osteosarcoma, Metastatic, Bone 1 (2%)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Adenoma 1 (2%)
Adrenal Medulla (58) (60) (59) (59)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 2 (3%) 1 (2%) 2 (3%) 1 (2%)
Islets, Pancreatic (60) (60) (59) (60)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Parathyroid Gland (58) (57) (57) (59)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (60) (60) (60) (60)
Pars Distalis, Adenoma 23 (38%) 23 (38%) 18 (30%) 22 (37%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Pars Distalis, Carcinoma 2 (3%)
Thyroid Gland (60) (60) (60) (60)
Bilateral, Follicular Cell, Carcinoma 1 (2%)
C-Cell, Adenoma 2 (3%) 2 (3%) 4 (7%) 5 (8%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 2 (3%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (59) (59) (59) (60)
Adenoma 11 (19%) 4 (7%) 5 (8%) 4 (7%)
Carcinoma 5 (8%) 3 (5%) 6 (10%) 3 (5%)
Bilateral, Carcinoma 1 (2%)
Ovary (60) (60) (60) (60)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Uterus (60) (60) (60) (60)
Page 3
NTP Experiment-Test: 05128-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 04/03/96
Route: DOSED FEED Time: 23:34:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.05% 0.17% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Adenoma 1 (2%)
Carcinoma 1 (2%)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Polyp Stromal 13 (22%) 13 (22%) 10 (17%) 6 (10%)
Polyp Stromal, Multiple 1 (2%)
Schwannoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Lymph Node (10) (13) (13) (17)
Lymph Node, Mandibular (60) (60) (60) (58)
Lymph Node, Mesenteric (60) (60) (60) (60)
Lymph Node, Mediastinal (1) (3) (2) (3)
Cholangiocarcinoma, Metastatic, Liver 1 (33%)
Spleen (60) (59) (60) (60)
Fibrous Histiocytoma 1 (2%)
Thymus (60) (58) (59) (58)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (60) (60)
Adenoma 2 (3%)
Carcinoma 5 (8%) 5 (8%) 2 (3%) 4 (7%)
Carcinoma, Multiple 1 (2%)
Fibroadenoma 14 (23%) 13 (22%) 18 (30%) 17 (28%)
Fibroadenoma, Multiple 7 (12%) 9 (15%) 5 (8%) 9 (15%)
Histiocytic Sarcoma 1 (2%)
Skin (59) (60) (60) (60)
Basal Cell Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Carcinoma 2 (3%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteosarcoma 1 (2%) 1 (2%) 1 (2%)
Skeletal Muscle (2) (1)
Osteosarcoma, Metastatic, Bone 1 (50%)
Rhabdomyosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05128-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 04/03/96
Route: DOSED FEED Time: 23:34:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.05% 0.17% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 2 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (3%) 1 (2%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (3%)
Carcinoma, Metastatic, Uterus 1 (2%)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Sarcoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Transitional Epithelium, Hemangioma 1 (2%)
Urinary Bladder (60) (60) (60) (60)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 16 (27%) 21 (35%) 19 (32%) 16 (27%)
Lymphoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05128-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 04/03/96
Route: DOSED FEED Time: 23:34:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.05% 0.17% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 52 53 53 53
Total Primary Neoplasms 115 111 110 119
Total Animals with Benign Neoplasms 44 46 44 43
Total Benign Neoplasms 80 74 74 78
Total Animals with Malignant Neoplasms 32 30 30 30
Total Malignant Neoplasms 35 37 36 41
Total Animals with Metastatic Neoplasms 1 1 4
Total Metastatic Neoplasm 1 5 8
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05128-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 04/03/96
Route: DOSED FEED Time: 23:34:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.05% 0.17% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 9 9 6
Early Deaths
Moribund Sacrifice 29 29 41 49
Natural Death 2 2 1 3
Survivors
Terminal Sacrifice 19 20 8 2
Other 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (59) (59) (58) (59)
Polyp Adenomatous 1 (2%)
Intestine Large, Cecum (60) (59) (59) (60)
Hemangioma 1 (2%)
Intestine Small, Jejunum (60) (59) (60) (60)
Carcinoma 1 (2%) 1 (2%)
Intestine Small, Ileum (59) (59) (59) (60)
Carcinoma 1 (2%)
Liver (60) (60) (60) (60)
Hepatocellular Adenoma 1 (2%) 2 (3%) 1 (2%) 6 (10%)
Hepatocellular Adenoma, Multiple 1 (2%)
Mesentery (12) (12) (10) (13)
Lipoma 1 (8%)
Oral Mucosa (2) (3) (4)
Squamous Cell Carcinoma 1 (50%) 1 (33%) 1 (25%)
Squamous Cell Papilloma 1 (50%) 1 (33%) 2 (50%)
Pancreas (60) (60) (60) (60)
Acinar Cell, Adenoma 1 (2%) 4 (7%) 2 (3%)
Salivary Glands (60) (60) (59) (60)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Stomach, Forestomach (60) (60) (60) (60)
Squamous Cell Papilloma 2 (3%)
Stomach, Glandular (60) (60) (60) (60)
Carcinoma 1 (2%)
Tongue (1) (1) (1) (4)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%) 1 (100%) 2 (50%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05128-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 04/03/96
Route: DOSED FEED Time: 23:34:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.05% 0.17% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Adrenal Medulla (60) (59) (60) (60)
Neuroblastoma Malignant 1 (2%)
Pheochromocytoma Malignant 4 (7%) 1 (2%) 2 (3%)
Pheochromocytoma Benign 7 (12%) 8 (14%) 11 (18%) 6 (10%)
Bilateral, Pheochromocytoma Benign 1 (2%) 2 (3%)
Islets, Pancreatic (60) (60) (60) (60)
Adenoma 4 (7%) 3 (5%)
Carcinoma 1 (2%) 2 (3%)
Pituitary Gland (60) (59) (58) (58)
Pars Distalis, Adenoma 21 (35%) 7 (12%) 13 (22%) 8 (14%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (2%) 2 (3%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (60) (60) (59) (60)
C-Cell, Adenoma 5 (8%) 2 (3%) 3 (5%) 3 (5%)
C-Cell, Adenoma, Multiple 1 (2%) 1 (2%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 3 (5%) 1 (2%) 1 (2%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2) (1) (3) (3)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (59) (60) (60) (60)
Preputial Gland (59) (59) (60) (60)
Adenoma 5 (8%) 2 (3%) 1 (2%)
Carcinoma 5 (8%) 4 (7%) 1 (2%) 2 (3%)
Prostate (60) (60) (60) (59)
Adenocarcinoma 1 (2%)
Seminal Vesicle (60) (60) (60) (60)
Testes (59) (60) (60) (60)
Bilateral, Interstitial Cell, Adenoma 30 (51%) 36 (60%) 42 (70%) 39 (65%)
Interstitial Cell, Adenoma 9 (15%) 13 (22%) 7 (12%) 7 (12%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05128-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 04/03/96
Route: DOSED FEED Time: 23:34:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.05% 0.17% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Lymph Node (22) (25) (30) (47)
Renal, Pheochromocytoma Malignant,
Metastatic, Adrenal Medulla 1 (5%)
Lymph Node, Mandibular (60) (59) (59) (59)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Lymph Node, Mesenteric (60) (59) (60) (60)
Spleen (60) (60) (60) (60)
Hemangiosarcoma 1 (2%)
Thymus (58) (58) (58) (59)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (57) (56) (58)
Fibroadenoma 3 (5%) 2 (4%) 3 (5%) 1 (2%)
Skin (60) (58) (60) (60)
Basal Cell Adenoma 1 (2%) 1 (2%) 2 (3%)
Basal Cell Carcinoma 2 (3%)
Keratoacanthoma 7 (12%) 4 (7%) 2 (3%) 1 (2%)
Squamous Cell Papilloma 3 (5%) 3 (5%) 2 (3%) 3 (5%)
Trichoepithelioma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Sebaceous Gland, Carcinoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 3 (5%) 2 (3%) 3 (5%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (2) (5) (9)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Hemangioma 1 (2%)
Spinal Cord (1) (2) (1)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05128-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 04/03/96
Route: DOSED FEED Time: 23:34:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.05% 0.17% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 7 (12%) 1 (2%) 2 (3%) 1 (2%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Osteosarcoma, Metastatic, Bone 1 (2%)
Renal Tubule, Adenoma 2 (3%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Mononuclear 37 (62%) 36 (60%) 20 (33%) 22 (37%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 2 (3%) 2 (3%) 3 (5%) 4 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05128-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 04/03/96
Route: DOSED FEED Time: 23:34:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.05% 0.17% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 51 55 51 50
Total Primary Neoplasms 171 144 140 128
Total Animals with Benign Neoplasms 50 53 50 50
Total Benign Neoplasms 112 95 103 90
Total Animals with Malignant Neoplasms 42 40 30 26
Total Malignant Neoplasms 59 49 37 38
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 3 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------