TDMS Study 05128-06 Pathology Tables
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
CORE ANIMALS
Facility: Southern Research Institute
Chemical CAS #: 8003-22-3
Lock Date: 01/12/93
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25026 Other 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 6| 1| 4| 0| 8| 4| 4| 9| 7| 4| 0| 4| 4| 4|
| 2| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 0| 2| 2| 7| 4| 2| 2| 9| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + + + + + + I + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Cytoplasmic Alteration | 3 3 |
Eosinophilic Focus | X X X X X X |
Granuloma | 1 1 1 1 2 1 1 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Subacute | |
Mixed Cell Focus | X X X X X X |
Necrosis, Focal | 4 |
Bile Duct, Hyperplasia | 1 2 1 1 1 1 1|
Centrilobular, Atrophy | 3 2|
Centrilobular, Necrosis | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 4 3 4 3|
Kupffer Cell, Pigmentation | 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + + + |
Accessory Spleen | |
Angiectasis | |
Fat, Necrosis | 2 3 3 3 2 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 3 1 1 |
Acinar Cell, Cytoplasmic Alteration | 4 4 |
Acinar Cell, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 3 2|
Fibrosis | |
Ulcer | 4 2 1 3 |
Mucosa, Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 6| 1| 4| 0| 8| 4| 4| 9| 7| 4| 0| 4| 4| 4|
| 2| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 0| 2| 2| 7| 4| 2| 2| 9| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 2 2 |
Ulcer | 2 |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2|
Degeneration, Fatty | 1 1 2 1 1|
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 1 2 |
Hypertrophy, Focal | 1 |
Hypertrophy | 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 |
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3|
Pars Distalis, Hyperplasia, Focal | 2 2 3 3 |
Pars Intermedia, Angiectasis | 3|
Pars Intermedia, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 |
C-Cell, Hyperplasia | 1 3 1 1 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
Hyperplasia | 2 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 6| 1| 4| 0| 8| 4| 4| 9| 7| 4| 0| 4| 4| 4|
| 2| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 0| 2| 2| 7| 4| 2| 2| 9| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Hyperplasia, Cystic | 1 1 2 4 |
__________________________________________________________________________|
Vagina | M M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Infiltration Cellular, Histiocyte | |
Myelofibrosis | 3 2 |
Necrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Pigmentation | 4 3 |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 2 2 2 2 1 3 |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 1 4 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 1 2 2 4 1 4 3 1 2 3 1 2 2 |
Infiltration Cellular, Histiocyte | 4 |
Necrosis | 3 |
Pigmentation | 3 3 3 2 2 2 3 2 4 2 2 2 3 3 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 4 2 3 4 2 4 2 3 2 2 3 3 3 2 2 2 3 3 2 4|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Cranium, Osteopetrosis | 3 2 2 2 |
Femur, Osteopetrosis | 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 6| 1| 4| 0| 8| 4| 4| 9| 7| 4| 0| 4| 4| 4|
| 2| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 0| 2| 2| 7| 4| 2| 2| 9| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X X X X X X |
Hydrocephalus | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 3 3 3 3 |
Foreign Body | X X |
Mucosa, Hyperplasia | 1 1 |
Mucosa, Metaplasia, Squamous | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 2 2 3 3 3 2 3 3 3 2 3 3 3 3 3 3 3 2 2 3 3 3|
Nephropathy | 3 1 1 1 1 1 1 1 1 1 1 4 1 1 1 3 3 2 1 2 1 1 1|
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Necrosis | 3 |
Renal Tubule, Pigmentation | 1 1 1 2 3|
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 4| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 4| 7| 3| 4| 4| 4| 4| 3| 4| 5| 4| 3| 4| 7| 4| 8| 4| 8| 3| 0| 4| 3| 4| 2| 4| |
| 2| 2| 0| 2| 2| 2| 2| 4| 2| 1| 2| 4| 2| 0| 2| 9| 2| 1| 4| 0| 2| 7| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 32 |
Clear Cell Focus | X X X X X X | 10 |
Cytoplasmic Alteration | | 2 3.0|
Eosinophilic Focus | X X X X | 10 |
Granuloma | 1 1 1 | 10 1.1|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hepatodiaphragmatic Nodule | X X X X | 7 |
Inflammation, Subacute | 1 1 | 2 1.0|
Mixed Cell Focus | X X X X X X | 12 |
Necrosis, Focal | 1 | 2 2.5|
Bile Duct, Hyperplasia | 1 1 2 1 1 2 2 | 14 1.3|
Centrilobular, Atrophy | 2 2 | 4 2.3|
Centrilobular, Necrosis | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 4 3 | 6 3.5|
Kupffer Cell, Pigmentation | 2 2 3 3 1 | 9 2.1|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 11 |
Accessory Spleen | X | 1 |
Angiectasis | 4 | 1 4.0|
Fat, Necrosis | 4 3 3 | 8 2.9|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 1 1 3 | 9 1.9|
Acinar Cell, Cytoplasmic Alteration | 3 | 3 3.7|
Acinar Cell, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 4| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 4| 7| 3| 4| 4| 4| 4| 3| 4| 5| 4| 3| 4| 7| 4| 8| 4| 8| 3| 0| 4| 3| 4| 2| 4| |
| 2| 2| 0| 2| 2| 2| 2| 4| 2| 1| 2| 4| 2| 0| 2| 9| 2| 1| 4| 0| 2| 7| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | 4 | 5 3.0|
Fibrosis | 2 | 1 2.0|
Ulcer | | 4 2.5|
Mucosa, Hyperplasia | 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 2 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 3 3 1 1 3 1 1| 16 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 2 3| 5 2.2|
Degeneration, Fatty | 1 2 2 1 | 9 1.3|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Focal | 2 | 3 1.7|
Hypertrophy, Focal | 2 2 | 3 1.7|
Hypertrophy | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 4 2 2 4 3 3 3 3 | 10 2.9|
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 25 3.0|
Pars Distalis, Hyperplasia, Focal | 3 3 3 3 1| 9 2.6|
Pars Intermedia, Angiectasis | 3 2 | 3 2.7|
Pars Intermedia, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 3 3 | 3 3.0|
C-Cell, Hyperplasia | 2 1 1 1 1 1 2 1| 13 1.3|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 4| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 4| 7| 3| 4| 4| 4| 4| 3| 4| 5| 4| 3| 4| 7| 4| 8| 4| 8| 3| 0| 4| 3| 4| 2| 4| |
| 2| 2| 0| 2| 2| 2| 2| 4| 2| 1| 2| 4| 2| 0| 2| 9| 2| 1| 4| 0| 2| 7| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 2 2.5|
Hyperplasia | 2 | 3 2.0|
Inflammation, Suppurative | 3 | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 3 3| 13 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 4 | 2 3.0|
Hyperplasia, Cystic | 3 | 5 2.2|
__________________________________________________________________________|____________|
Vagina | M + M M | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 3 | 4 3.3|
Infiltration Cellular, Histiocyte | 4 | 1 4.0|
Myelofibrosis | 4 | 3 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 9 |
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Pigmentation | 3 3 3 | 5 3.2|
Pancreatic, Hemorrhage | 2 | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0|
Pancreatic, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 2.0|
Hemorrhage | 2 2 1 2 | 10 1.9|
Hyperplasia, Lymphoid | 4 3 2 | 5 2.6|
Pigmentation | 2 2 2 3 2 2 2 2 | 23 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 5 2.4|
Hyperplasia, Lymphoid | 4 | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 3 2 3 4 3 2 3 2 2| 27 2.4|
Infiltration Cellular, Histiocyte | | 1 4.0|
Necrosis | | 1 3.0|
Pigmentation | 2 2 3 3 2 2 2 2 2 2 2 3 3 2| 30 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 4| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 4| 7| 3| 4| 4| 4| 4| 3| 4| 5| 4| 3| 4| 7| 4| 8| 4| 8| 3| 0| 4| 3| 4| 2| 4| |
| 2| 2| 0| 2| 2| 2| 2| 4| 2| 1| 2| 4| 2| 0| 2| 9| 2| 1| 4| 0| 2| 7| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 4 3 3 2 3 2 4 2 3 2 2 4 2 3 4 2 2 2 3 3| 46 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + I + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 | 1 2.0|
Cranium, Osteopetrosis | 3 2 | 6 2.3|
Femur, Osteopetrosis | 2 2 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X X X | 9 |
Hydrocephalus | 2 | 2 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + + + | 3 |
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | 3 | 5 3.0|
Foreign Body | | 2 |
Mucosa, Hyperplasia | 1 2 | 4 1.3|
Mucosa, Metaplasia, Squamous | 1 | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 3 3 2 3 3 3 3 2 3 3 3 3 1 1 3 3 2 2 3 3 2 3 2| 48 2.6|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 2 1 1 2 1 3 1| 45 1.4|
Renal Tubule, Cytoplasmic Alteration | 3 | 1 3.0|
Renal Tubule, Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 4| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 4| 7| 3| 4| 4| 4| 4| 3| 4| 5| 4| 3| 4| 7| 4| 8| 4| 8| 3| 0| 4| 3| 4| 2| 4| |
| 2| 2| 0| 2| 2| 2| 2| 4| 2| 1| 2| 4| 2| 0| 2| 9| 2| 1| 4| 0| 2| 7| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Pigmentation | 1 1 1 1 1 | 10 1.3|
Transitional Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 5| 6| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 4| 2| 4| 4| 4| 4| 7| 4| 2| 3| 4| 8| 4| 8| 2| 2| 0| 4| 4| 4| 2| 4| 0| 4|
| 4| 0| 2| 0| 0| 0| 0| 2| 0| 2| 1| 8| 8| 0| 8| 9| 6| 8| 0| 5| 0| 8| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05% | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | I + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X |
Cyst | 3 |
Eosinophilic Focus | X X X X |
Granuloma | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Subacute | |
Mixed Cell Focus | X X X X X X X X X X |
Necrosis, Focal | 1 1 |
Thrombosis | 3 |
Bile Duct, Hyperplasia | 2 2 2 2 2 |
Bile Duct, Pigmentation | 2 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 2 2 1 1 1|
Centrilobular, Atrophy | 2 2 3 3 2 |
Hepatocyte, Cytologic Alterations | 2 2 2 2 3 |
Hepatocyte, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 3 4 3 |
Kupffer Cell, Pigmentation | 3 1 3 1 3 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Fat, Necrosis | 2 2 2 3 3 3 3 3 2 2 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 2 2 3 3 3 1 1 |
Acinar Cell, Cytoplasmic Alteration | 3 4 |
Acinar Cell, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 5| 6| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 4| 2| 4| 4| 4| 4| 7| 4| 2| 3| 4| 8| 4| 8| 2| 2| 0| 4| 4| 4| 2| 4| 0| 4|
| 4| 0| 2| 0| 0| 0| 0| 2| 0| 2| 1| 8| 8| 0| 8| 9| 6| 8| 0| 5| 0| 8| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05% | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Hyperplasia | 1 1 1 1 1 1 2 2 1 2 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 3 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 1 1 1 X 1 2 |
Angiectasis | 3 |
Degeneration, Fatty | 1 3 1 1 1 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 4 |
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 |
C-Cell, Hyperplasia | 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3|
Hyperplasia | 2|
Inflammation, Suppurative | 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 5| 6| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 4| 2| 4| 4| 4| 4| 7| 4| 2| 3| 4| 8| 4| 8| 2| 2| 0| 4| 4| 4| 2| 4| 0| 4|
| 4| 0| 2| 0| 0| 0| 0| 2| 0| 2| 1| 8| 8| 0| 8| 9| 6| 8| 0| 5| 0| 8| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05% | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3 4 2 2|
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Vagina | M M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Myelofibrosis | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + +|
Deep Cervical, Pigmentation | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | 3 |
Pancreatic, Pigmentation | 3 |
Renal, Hemorrhage | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 1 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + M +|
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 2 2 1 2 2 3 1 2 2 2 |
Metaplasia, Osseous | |
Pigmentation | 2 2 2 2 2 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + M +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 4 2 2 2 2 2 2 2 1 3 2 3 2 2 1 4 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
Cranium, Osteopetrosis | 2 3 3 2 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 5| 6| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 4| 2| 4| 4| 4| 4| 7| 4| 2| 3| 4| 8| 4| 8| 2| 2| 0| 4| 4| 4| 2| 4| 0| 4|
| 4| 0| 2| 0| 0| 0| 0| 2| 0| 2| 1| 8| 8| 0| 8| 9| 6| 8| 0| 5| 0| 8| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05% | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Femur, Osteopetrosis | 2 3 2 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X X X X X |
__________________________________________________________________________|
Peripheral Nerve | + |
Degeneration | 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1|
Inflammation, Subacute | 1 2 |
Alveolar Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 3 |
Foreign Body | X |
Mucosa, Hyperplasia | |
Mucosa, Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 3 |
Retina, Degeneration | 4 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mineralization | 1 2 1 2 3 2 2 2 2 2 2 2 1 2 3 3 1 2 2 1 2 1 2 2|
Nephropathy | 2 1 3 1 3 1 1 2 1 1 1 1 2 1 2 2 1 2 1 3 1 3 4 2|
Renal Tubule, Cytoplasmic Alteration | 2 |
Renal Tubule, Pigmentation | 2 2 1 2 2 2 2 1 1 1 1 2 2 1 1 2 3 2 2 2 2 2 2 2 2|
Transitional Epithelium, Hyperplasia | 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 4|
DAY ON TEST | 4| 4| 4| 4| 0| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 4| 4| 4| 4| 0| 4| 4| 4| 6|
| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 6| 1| 1| 1| 1| 0| 1| 1| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05% | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M I + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X |
Cyst | 3 3 |
Eosinophilic Focus | X X X X X |
Granuloma | 1 |
Hematopoietic Cell Proliferation | 3|
Hepatodiaphragmatic Nodule | X |
Inflammation, Subacute | 1 |
Mixed Cell Focus | X X X X X X X X X |
Necrosis, Focal | |
Thrombosis | |
Bile Duct, Hyperplasia | 1 1 2 2 1 |
Bile Duct, Pigmentation | 1 2 2 1 1 1 2 1 2 2 1 1 1 1 1 1 1 1 1 1 1 2 2|
Centrilobular, Atrophy | 2 2 2 2 |
Hepatocyte, Cytologic Alterations | 2 3 2 2 2 3|
Hepatocyte, Pigmentation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 3 2|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 2 |
Kupffer Cell, Pigmentation | 2 2 2 4 2 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Fat, Necrosis | 2 3 2 4 2 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 1 3 1 2 2 2 1 |
Acinar Cell, Cytoplasmic Alteration | |
Acinar Cell, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 4|
DAY ON TEST | 4| 4| 4| 4| 0| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 4| 4| 4| 4| 0| 4| 4| 4| 6|
| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 6| 1| 1| 1| 1| 0| 1| 1| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05% | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Hyperplasia | 1 1 2 1 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Erosion | |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 2 2 2 3 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 2 1 |
Angiectasis | 3 |
Degeneration, Fatty | 3 1 2 2 |
Hematopoietic Cell Proliferation | 3|
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2 3 |
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 3 3 |
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 3 3 3|
Pars Distalis, Hyperplasia, Focal | 2 3 2 2 |
Pars Intermedia, Angiectasis | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 3 3 3 |
C-Cell, Hyperplasia | 1 2 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | 2 |
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 4|
DAY ON TEST | 4| 4| 4| 4| 0| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 4| 4| 4| 4| 0| 4| 4| 4| 6|
| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 6| 1| 1| 1| 1| 0| 1| 1| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05% | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 1 |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Deep Cervical, Pigmentation | 4|
Mediastinal, Hemorrhage | 1 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 2|
Mediastinal, Pigmentation | 3 3 3 3 3 3|
Pancreatic, Pigmentation | 3 |
Renal, Hemorrhage | 2 |
Renal, Pigmentation | 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 2|
Hemorrhage | 1 2 1 1 3 1 1 2 2|
Hyperplasia, Lymphoid | 2 3 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 4|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 2 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 4|
Metaplasia, Osseous | 3 |
Pigmentation | 3 2 2 3 2 2 2 2 2 3 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 3 2 2 2 3 2 2 2 2 4 3 2 3 2 2 3 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Cranium, Osteopetrosis | 3 3 2|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 4|
DAY ON TEST | 4| 4| 4| 4| 0| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 4| 4| 4| 4| 0| 4| 4| 4| 6|
| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 6| 1| 1| 1| 1| 0| 1| 1| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05% | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Femur, Osteopetrosis | 3 2 3|
__________________________________________________________________________|
Skeletal Muscle | + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X X X X X |
__________________________________________________________________________|
Peripheral Nerve | + |
Degeneration | |
Inflammation, Chronic | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1|
Inflammation, Subacute | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 3 3 3 3 |
Foreign Body | |
Mucosa, Hyperplasia | 1 2 |
Mucosa, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mineralization | 2 2 2 2 2 1 1 3 1 2 2 1 2 1 2 1 1 2 1 2 2 3 2 1|
Nephropathy | 1 2 1 1 3 1 2 2 1 2 2 1 3 1 1 2 1 2 1 1 2 1 |
Renal Tubule, Cytoplasmic Alteration | 3 |
Renal Tubule, Pigmentation | 2 2 2 2 2 1 3 3 1 1 3 1 1 1 2 1 2 2 2 2 3 1|
Transitional Epithelium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 4| | |
| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 3| | A |
0.05% | 6| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 50 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 51 |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 51 |
Ulcer | | 1 3.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 51 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 51 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + | 51 |
Angiectasis | | 2 2.0|
Basophilic Focus | X | 26 |
Clear Cell Focus | X | 18 |
Cyst | | 3 3.0|
Eosinophilic Focus | | 9 |
Granuloma | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hepatodiaphragmatic Nodule | | 4 |
Inflammation, Subacute | | 1 1.0|
Mixed Cell Focus | | 19 |
Necrosis, Focal | | 2 1.0|
Thrombosis | | 1 3.0|
Bile Duct, Hyperplasia | | 10 1.7|
Bile Duct, Pigmentation | 1 | 46 1.3|
Centrilobular, Atrophy | | 9 2.2|
Hepatocyte, Cytologic Alterations | | 11 2.3|
Hepatocyte, Pigmentation | 1 | 34 1.1|
Hepatocyte, Vacuolization Cytoplasmic| | 6 3.0|
Kupffer Cell, Pigmentation | | 11 2.4|
__________________________________________________________________________|____________|
Mesentery | + | 18 |
Fat, Necrosis | 2 | 16 2.5|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Atrophy | 1 | 19 1.9|
Acinar Cell, Cytoplasmic Alteration | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 4| | |
| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 3| | A |
0.05% | 6| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinar Cell, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 46 |
Atrophy | | 8 1.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Ulcer | | 1 4.0|
Mucosa, Hyperplasia | | 17 1.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Edema | | 2 2.0|
Erosion | | 1 3.0|
Ulcer | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 51 |
__________________________________________________________________________|____________|
Heart | + | 51 |
Cardiomyopathy | | 18 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Accessory Adrenal Cortical Nodule | 2 | 13 1.3|
Angiectasis | | 2 3.0|
Degeneration, Fatty | | 10 1.7|
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Focal | | 2 2.0|
Hypertrophy, Focal | | 2 2.5|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 48 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + | 51 |
Pars Distalis, Angiectasis | | 6 3.0|
Pars Distalis, Cyst | | 21 3.0|
Pars Distalis, Hyperplasia, Focal | | 4 2.3|
Pars Intermedia, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Ultimobranchial Cyst | | 5 3.0|
C-Cell, Hyperplasia | | 7 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 4| | |
| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 3| | A |
0.05% | 6| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 50 |
Cyst | | 4 2.8|
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + | 51 |
Cyst | | 14 3.0|
__________________________________________________________________________|____________|
Uterus | + | 51 |
Hydrometra | | 8 2.4|
Hyperplasia, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Hyperplasia | | 1 3.0|
Myelofibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 11 |
Deep Cervical, Pigmentation | | 1 4.0|
Mediastinal, Hemorrhage | | 2 1.5|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.0|
Mediastinal, Pigmentation | | 7 3.0|
Pancreatic, Pigmentation | | 2 3.0|
Renal, Hemorrhage | | 1 2.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 51 |
Ectasia | | 3 2.7|
Hemorrhage | | 11 1.5|
Hyperplasia, Lymphoid | | 10 2.1|
Pigmentation | 2 | 24 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 51 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 5 2.2|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 1 |
__________________________________________________________________________|____________|
Spleen | + | 50 |
Fibrosis | | 3 2.3|
Hematopoietic Cell Proliferation | 2 | 23 2.0|
Metaplasia, Osseous | | 1 3.0|
Pigmentation | 2 | 30 2.2|
__________________________________________________________________________|____________|
Thymus | + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 4| | |
| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 3| | A |
0.05% | 6| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
Hyperplasia | 2 | 42 2.2|
__________________________________________________________________________|____________|
Skin | + | 51 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
Hyperostosis | | 1 2.0|
Cranium, Osteopetrosis | | 7 2.6|
Femur, Osteopetrosis | | 7 2.4|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Developmental Malformation | X | 11 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
Degeneration | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Infiltration Cellular, Histiocyte | 1 | 33 1.2|
Inflammation, Subacute | | 3 1.3|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + | 51 |
Exudate | | 5 3.0|
Foreign Body | | 1 |
Mucosa, Hyperplasia | | 2 1.5|
Mucosa, Metaplasia, Squamous | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 3.5|
Retina, Degeneration | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 4| | |
| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 3| | A |
0.05% | 6| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Inflammation, Suppurative | 1 | 1 1.0|
Mineralization | 2 | 49 1.8|
Nephropathy | 3 | 47 1.7|
Renal Tubule, Cytoplasmic Alteration | | 2 2.5|
Renal Tubule, Pigmentation | 1 | 48 1.8|
Transitional Epithelium, Hyperplasia | | 6 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 9| 5| 4| 4| 6| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 0| 1| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.17% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X X X X X|
Cyst | 2 4 |
Eosinophilic Focus | X X X X X X X X |
Granuloma | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Subacute | 1 1 |
Mixed Cell Focus | X X X X X X X X X X X |
Necrosis, Focal | 1 1 |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 2 2 2 1 2 1 1 1 1 2 |
Bile Duct, Pigmentation | 2 2 2 2 2 3 2 2 2 2 2 2 3 2 2 2 2 1 2 2 2 2 2 2 1|
Centrilobular, Atrophy | 2 3 3 |
Hepatocyte, Cytologic Alterations | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 3 2 |
Hepatocyte, Pigmentation | 2 2 2 3 2 2 3 2 2 3 2 2 2 2 2 2 2 1 2 2 2 3|
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Pigmentation | 2 2 2 3 1 1 1 3 1|
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 4 2|
Necrosis | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 1 2 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Mucosa, Hyperplasia | 2 2 2 1 1 2 2 1 1 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 9| 5| 4| 4| 6| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 0| 1| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.17% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 2 1 2 2 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 1 1 3 1 |
Angiectasis | |
Degeneration, Fatty | 1 1 2 |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 2|
Hypertrophy, Focal | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + I + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 3 2 3 3 3 2 2 |
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Pars Distalis, Hyperplasia, Focal | 2 3 2 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 3 3 |
C-Cell, Hyperplasia | 2 3 1 1 2 1 |
Follicle, Cyst | 3 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Hyperplasia, Cystic | 2 2 |
__________________________________________________________________________|
Vagina | M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 9| 5| 4| 4| 6| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 0| 1| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.17% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Hemorrhage | 1 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Pigmentation | 3 3 3 3 |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Pigmentation | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 2 |
Hemorrhage | 1 1 2 1 1 1 2 3 2 1 2|
Hyperplasia, Lymphoid | 3 3 4 2 2 2 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 3 2 2 2 2 2 3 2 2 2 2 2 2 2|
Necrosis | 4 |
Pigmentation | 2 2 2 2 3 3 2 2 2 2 3 3 3 2 2|
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 2 2 3 2 2 3 1 3 2 2 2 1 1 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 2 |
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X X X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 9| 5| 4| 4| 6| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 0| 1| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.17% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 3 3 |
Foreign Body | X X |
Mucosa, Hyperplasia | |
Mucosa, Metaplasia, Squamous | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 2 2 3 2 2 2 1 1 2 2 1 1 2 2 2 2 2 2 2 2|
Nephropathy | 1 2 1 2 2 1 2 3 2 1 1 1 1 2 1 3 1 1 2 1 2 1 1 3|
Renal Tubule, Cytoplasmic Alteration | 3 |
Renal Tubule, Pigmentation | 3 3 4 3 3 3 2 4 2 3 3 3 3 3 2 2 3 3 3 3 3 3 3 2 2|
Transitional Epithelium, Hyperplasia | 3 1 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 1| 2| 4| 4| 4| 7| 4| 3| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 4| 2| 4| 4| |
| 1| 1| 1| 9| 2| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 8| 1| 1| 1| 6| 0| 1| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.17% | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X| 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 3 2.3|
Basophilic Focus | X X X X | 11 |
Clear Cell Focus | X X X X X X X X X X X X | 29 |
Cyst | 3 3 | 4 3.0|
Eosinophilic Focus | X X X X X X| 14 |
Granuloma | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 3 2 | 2 2.5|
Hepatodiaphragmatic Nodule | X | 5 |
Inflammation, Subacute | 1 | 3 1.0|
Mixed Cell Focus | X X X X X X X X X| 20 |
Necrosis, Focal | 1 1 1 | 5 1.0|
Thrombosis | 3 | 2 2.5|
Bile Duct, Hyperplasia | 1 2 2 2 2 2 1 1 1 2 2 1 1 1 2 1| 27 1.5|
Bile Duct, Pigmentation | 1 2 2 2 2 1 3 2 2 3 2 2 2 2 2 2 2 2 2 1 2 2 2 2| 49 2.0|
Centrilobular, Atrophy | 2 2 | 5 2.4|
Hepatocyte, Cytologic Alterations | 2 2 2 2 2 2 2 2 2 3 2 2 2| 31 2.1|
Hepatocyte, Pigmentation | 1 3 1 2 3 1 2 3 3 2 3 1 1 2 2 3 2 2 2 2 1 3| 44 2.1|
Hepatocyte, Vacuolization Cytoplasmic| 4 4 | 2 4.0|
Kupffer Cell, Pigmentation | 2 2 1 2 1 2 2 | 16 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Fat, Necrosis | 4 2 2 3 2 | 8 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 1 3 1 3 3 2 1 2 3 2 1 | 17 2.1|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2| 7 1.7|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 1| 2| 4| 4| 4| 7| 4| 3| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 4| 2| 4| 4| |
| 1| 1| 1| 9| 2| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 8| 1| 1| 1| 6| 0| 1| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.17% | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Hyperplasia | 1 1 2 2 2 2 1 1 2 2 1 1 2 2 2 2 1 2 1| 30 1.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 1 1 1 3 | 18 1.7|
Thrombosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 1 2 3 2 | 11 1.7|
Angiectasis | 3 3 | 2 3.0|
Degeneration, Fatty | 3 2 2 1 4 3 | 9 2.1|
Hyperplasia, Diffuse | 4 | 1 4.0|
Hyperplasia, Focal | 1 | 2 1.5|
Hypertrophy, Focal | 1 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + M + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 4 2 2 4 3| 16 2.6|
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 3 | 25 3.0|
Pars Distalis, Hyperplasia, Focal | 2 2 3 3 2| 8 2.4|
Pars Intermedia, Angiectasis | | 1 2.0|
Pars Intermedia, Cyst | | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 3 | 4 3.0|
C-Cell, Hyperplasia | 1 3 2 2 | 10 1.8|
Follicle, Cyst | 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05128-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC D & C YELLOW NO. 11 Date: 10/30/95
Route: DOSED FEED Time: 12:27:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 1| 2| 4| 4| 4| 7| 4| 3| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 4| 2| 4| 4| |
| 1| 1| 1| 9| 2| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 8| 1| 1| 1| 6| 0| 1| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.17% | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Cyst