TDMS Study 05130-02 Pathology Tables
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
Facility: Microbiological Associates
Chemical CAS #: 10401-500
Lock Date: 10/29/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 7| 1| 7| 7| 7| 7| 3| 7|
DAY ON TEST | 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 2| 6| 4|
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 8| 4| 4| 4| 4| 4| 4| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + A + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 2 |
Basophilic Focus | X |
Clear Cell Focus | X X |
Cyst | |
Eosinophilic Focus | X X X X X |
Fatty Change, Focal | 3 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic, Focal | 2 |
Mixed Cell Focus | X |
Necrosis, Focal | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Chronic Active, Focal | 2 |
Acinar Cell, Hypertrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic, | |
Multifocal | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic, | |
Focal | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 7| 1| 7| 7| 7| 7| 3| 7|
DAY ON TEST | 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 2| 6| 4|
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 8| 4| 4| 4| 4| 4| 4| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Congestion | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + M + + M M M M + + M + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Arteriole, Inflammation, Chronic, | |
Focal | 3 |
Follicle, Dilatation, Focal | 2 |
Follicular Cell, Hyperplasia, Focal | 1 1 2 2|
Follicular Cell, Hypertrophy, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X X 1 |
Hemorrhage, Focal | 2 |
Inflammation, Chronic, Focal | 4 |
Bilateral, Abscess | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 2 2 2 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 2 |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 2 2 3 2 2 2 2 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | |
Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | 3 |
Lumbar, Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 7| 1| 7| 7| 7| 7| 3| 7|
DAY ON TEST | 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 2| 6| 4|
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 8| 4| 4| 4| 4| 4| 4| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Plasma Cell | 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 2 1 2 |
Hyperplasia, Plasma Cell | |
Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + M + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 3 3 |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 3 2 2 2 1 2 2|
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | 2 |
Depletion Lymphoid | 3 |
Hyperplasia, Lymphoid | 3 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
Inflammation, Chronic Active, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 1 2 1 2 2 2 2 1 2 2 2 2 2 1 1 |
Necrosis, Focal | 3 |
Artery, Inflammation, Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 7| 1| 7| 7| 7| 7| 3| 7|
DAY ON TEST | 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 2| 6| 4|
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 8| 4| 4| 4| 4| 4| 4| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Arteriole, Inflammation, Chronic, | |
Focal | 2 |
__________________________________________________________________________|
Eye | +|
Cornea, Inflammation, Chronic | 2|
__________________________________________________________________________|
Harderian Gland | +|
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + M + + M + + M M + + + +|
Inflammation, Acute, Focal | |
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Metaplasia, Focal, Osseous | 1 |
Nephropathy | 1 |
Artery, Inflammation, Chronic, Focal | 3 |
Glomerulus, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 |
Arteriole, Inflammation, Chronic, | |
Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 0| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 1| 4| 4| 4| 0| 4| 4| 4| 4| 4| 2| 4| 1| 4| 4| 4|
| 4| 4| 4| 4| 8| 4| 3| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 4| 7| 4| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X|
Clear Cell Focus | |
Cyst | X |
Eosinophilic Focus | X X X X X X |
Fatty Change, Focal | |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic, Focal | |
Mixed Cell Focus | |
Necrosis, Focal | 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis, Focal | 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Inflammation, Chronic Active, Focal | 2 |
Acinar Cell, Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic, | |
Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 0| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 1| 4| 4| 4| 0| 4| 4| 4| 4| 4| 2| 4| 1| 4| 4| 4|
| 4| 4| 4| 4| 8| 4| 3| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 4| 7| 4| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Congestion | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + M + + + M + + + M + M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 1 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 1 |
Arteriole, Inflammation, Chronic, | |
Focal | |
Follicle, Dilatation, Focal | 2 |
Follicular Cell, Hyperplasia, Focal | 2 2 2 2 2 2 3|
Follicular Cell, Hypertrophy, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + A + + + + + + + + + M + + +|
Abscess | 3 2 |
Cyst | X X X X X X X X X|
Hemorrhage, Focal | |
Inflammation, Chronic, Focal | 4 |
Bilateral, Abscess | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 3 3 2 2 3 3 |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 |
Endometrium, Hyperplasia, Cystic | 2 3 2 2 3 2 3 2 3 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | 2 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Iliac, Hyperplasia, Plasma Cell | |
Lumbar, Hyperplasia, Lymphoid | 3 3 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 0| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 1| 4| 4| 4| 0| 4| 4| 4| 4| 4| 2| 4| 1| 4| 4| 4|
| 4| 4| 4| 4| 8| 4| 3| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 4| 7| 4| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Hyperplasia, Plasma Cell | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| |
Renal, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2|
Inflammation, Acute | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 2 3 |
Hyperplasia, Lymphoid | 3 2 1 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + M + + + + + + + + + + + + + + +|
Cyst | |
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic Active, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 2 1 2 1 2 1 1 1 1 1 2 2|
Necrosis, Focal | |
Artery, Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 0| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 1| 4| 4| 4| 0| 4| 4| 4| 4| 4| 2| 4| 1| 4| 4| 4|
| 4| 4| 4| 4| 8| 4| 3| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 4| 7| 4| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Focal, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Arteriole, Inflammation, Chronic, | |
Focal | |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | + + + + M + + + M M + + + M + + + + + + + + + +|
Inflammation, Acute, Focal | 2 |
Duct, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Metaplasia, Focal, Osseous | 2 |
Nephropathy | 1 2 3 |
Artery, Inflammation, Chronic, Focal | |
Glomerulus, Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + +|
Inflammation, Acute | |
Arteriole, Inflammation, Chronic, | |
Focal | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 49 |
__________________________________________________________________________|____________|
Gallbladder | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 46 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 48 |
__________________________________________________________________________|____________|
Liver | | 49 |
Angiectasis, Focal | | 4 2.0|
Basophilic Focus | | 4 |
Clear Cell Focus | | 2 |
Cyst | | 1 |
Eosinophilic Focus | | 11 |
Fatty Change, Focal | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Fat, Necrosis, Focal | | 6 2.2|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Accessory Spleen | | 1 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Chronic Active, Focal | | 2 2.0|
Acinar Cell, Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
Arteriole, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 49 |
Arteriole, Inflammation, Chronic, | | |
Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 49 |
Cyst | | 1 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | | 49 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 33 |
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
Pars Distalis, Angiectasis, Focal | | 2 1.5|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | | 6 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 2 1.5|
Arteriole, Inflammation, Chronic, | | |
Focal | | 1 3.0|
Follicle, Dilatation, Focal | | 2 2.0|
Follicular Cell, Hyperplasia, Focal | | 11 1.9|
Follicular Cell, Hypertrophy, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | | 47 |
Abscess | | 2 2.5|
Cyst | | 12 1.0|
Hemorrhage, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 2 4.0|
Bilateral, Abscess | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | | 49 |
Dilatation | | 13 2.6|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | | 2 2.5|
Endometrium, Hyperplasia, Cystic | | 31 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Congestion | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia | | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node | | 9 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Iliac, Hyperplasia, Plasma Cell | | 1 3.0|
Lumbar, Hyperplasia, Lymphoid | | 3 3.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 2 2.5|
Renal, Hyperplasia, Plasma Cell | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Cyst | | 2 |
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | | 3 1.7|
Hyperplasia, Plasma Cell | | 1 2.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 46 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 5 2.4|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 48 |
Depletion Lymphoid | | 1 3.0|
Hematopoietic Cell Proliferation | | 10 2.1|
Hyperplasia, Lymphoid | | 6 2.3|
__________________________________________________________________________|____________|
Thymus | | 46 |
Cyst | | 1 2.0|
Depletion Lymphoid | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
__________________________________________________________________________|____________|
Skin | | 49 |
Inflammation, Acute, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
Mineralization, Focal | | 29 1.6|
Necrosis, Focal | | 1 3.0|
Artery, Inflammation, Chronic, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 49 |
Congestion | | 1 2.0|
Hemorrhage, Focal | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 49 |
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Arteriole, Inflammation, Chronic, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 38 |
Inflammation, Acute, Focal | | 1 2.0|
Duct, Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Metaplasia, Focal, Osseous | | 2 1.5|
Nephropathy | | 4 1.8|
Artery, Inflammation, Chronic, Focal | | 1 3.0|
Glomerulus, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | | 48 |
Inflammation, Acute | | 1 4.0|
Arteriole, Inflammation, Chronic, | | |
Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4|
| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M + + + + + + + + + + M +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4|
Intussusception | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 |
Basophilic Focus | X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X|
Fatty Change, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2|
Mixed Cell Focus | X |
Necrosis, Focal | 1 |
Centrilobular, Cytomegaly | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Inflammation, Chronic Active, Focal | 3 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + M +|
Cytoplasmic Alteration, Focal | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Focal | 2|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4|
| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + M + + + M + M + + + + + + + + M +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 |
Follicular Cell, Hyperplasia, Focal | 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X |
Hematocyst | X |
Infiltration Cellular, Focal, | |
Lymphocyte | 3 |
Mineralization, Focal | 2 |
Pigmentation, Focal | 3 |
Follicle, Hyperplasia, Cystic, Focal | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 3 4 4 3 4|
Thrombosis, Focal | 3 |
Endometrium, Hyperplasia, Cystic | 2 3 4 3 3 3 2 1 1 3 2 2 2 2 2 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + M + + + + + + +|
Congestion | 1 |
Cyst | |
Edema | |
Hyperplasia, Lymphoid | 2 3 2 |
Hyperplasia, Plasma Cell | 3 |
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4|
| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 2 2 3 2|
Hyperplasia, Lymphoid | 2 2 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | X|
Hemorrhage, Focal | 2 |
Hyperplasia, Lymphoid | 2 2 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 2 |
Inflammation, Chronic Active, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Intervertebral Disc, Dysplasia, Focal| 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hydrocephalus | 2 |
Mineralization, Focal | 1 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 1 2 2 1 2|
__________________________________________________________________________|
Spinal Cord | + |
Infiltration Cellular, Focal, | |
Histiocyte | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 3 |
Infiltration Cellular, Focal, | |
Histiocyte | 2 |
Interstitium, Inflammation, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Inflammation, Chronic Active, | |
Focal | 3 |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4|
| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Lens, Cataract | 2 |
__________________________________________________________________________|
Zymbal's Gland | + I + + M + + + + M M + M M + + + + + + + + + M +|
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 3 |
Metaplasia, Focal, Osseous | |
Nephropathy | 3 |
Glomerulus, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4|
| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + + + + + M + + + M +|
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Intussusception | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 1 |
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X |
Fatty Change, Focal | 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Mixed Cell Focus | |
Necrosis, Focal | |
Centrilobular, Cytomegaly | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Inflammation, Chronic Active, Focal | |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Focal | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4|
| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + M M M M + M + + + + M + M M + + + M|
Infiltration Cellular, Focal, | |
Lymphocyte | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
Follicular Cell, Hyperplasia, Focal | 2 2 4 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X 1 X X X X X X |
Hematocyst | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Mineralization, Focal | |
Pigmentation, Focal | |
Follicle, Hyperplasia, Cystic, Focal | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 3 4 |
Thrombosis, Focal | |
Endometrium, Hyperplasia, Cystic | 2 3 3 2 3 4 4 2 2 3 3 2 3 2 2 2 2 3 2 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Lumbar, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X X X |
Edema | 2 |
Hyperplasia, Lymphoid | 3 1 2 1 |
Hyperplasia, Plasma Cell | 3 |
Infiltration Cellular, Mast Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + M + + + + +|
Angiectasis, Focal | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4|
| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 2 2 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | X|
Hemorrhage, Focal | |
Hyperplasia, Lymphoid | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | |
Inflammation, Chronic Active, Focal | 3 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
Intervertebral Disc, Dysplasia, Focal| |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 |
Hydrocephalus | |
Mineralization, Focal | 2 2 2 1 2 2 1 2 2 1 2 2 2 2 2 2 1 2 2 1 2 2 2 2|
__________________________________________________________________________|
Spinal Cord | |
Infiltration Cellular, Focal, | |
Histiocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Infiltration Cellular, Focal, | |
Histiocyte | 2 |
Interstitium, Inflammation, Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Inflammation, Chronic Active, | |
Focal | |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4|
| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Lens, Cataract | |
__________________________________________________________________________|
Zymbal's Gland | + + + + M + + M + + + + + M + + + + + M M + + + +|
Duct, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Metaplasia, Focal, Osseous | 2 |
Nephropathy | 1 1|
Glomerulus, Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 45 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
Hyperplasia, Lymphoid | | 1 4.0|
Intussusception | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Focal | | 3 1.7|
Basophilic Focus | | 2 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | | 7 |
Fatty Change, Focal | | 1 1.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 2 2.0|
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 1 1.0|
Centrilobular, Cytomegaly | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Necrosis, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Accessory Spleen | | 1 |
Inflammation, Chronic Active, Focal | | 1 3.0|
Duct, Dilatation | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Ulcer, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Inflammation, Acute, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 49 |
Cytoplasmic Alteration, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | | 49 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 34 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | | 11 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia, Focal | | 1 1.0|
Follicular Cell, Hyperplasia, Focal | | 9 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 50 |
Cyst | | 17 1.0|
Hematocyst | | 1 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 3.0|
Mineralization, Focal | | 1 2.0|
Pigmentation, Focal | | 1 3.0|
Follicle, Hyperplasia, Cystic, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | | 50 |
Dilatation | | 12 3.4|
Thrombosis, Focal | | 1 3.0|
Endometrium, Hyperplasia, Cystic | | 42 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 10 |
Lumbar, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Congestion | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | | 3 |
Edema | | 1 2.0|
Hyperplasia, Lymphoid | | 7 2.0|
Hyperplasia, Plasma Cell | | 2 3.0|
Infiltration Cellular, Mast Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 48 |
Angiectasis, Focal | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 9 2.2|
Hyperplasia, Lymphoid | | 5 2.4|
__________________________________________________________________________|____________|
Thymus | | 48 |
Cyst | | 2 |
Hemorrhage, Focal | | 1 2.0|
Hyperplasia, Lymphoid | | 3 2.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
__________________________________________________________________________|____________|
Skin | | 50 |
Acanthosis, Focal | | 1 2.0|
Inflammation, Chronic Active, Focal | | 4 2.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Fibrous Osteodystrophy | | 1 3.0|
Intervertebral Disc, Dysplasia, Focal| | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hemorrhage, Focal | | 1 1.0|
Hydrocephalus | | 1 2.0|
Mineralization, Focal | | 45 1.8|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Infiltration Cellular, Focal, | | |
Histiocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Hemorrhage, Focal | | 1 3.0|
Infiltration Cellular, Focal, | | |
Histiocyte | | 2 2.0|
Interstitium, Inflammation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Inflammation, Acute, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Inflammation, Chronic Active, | | |
Focal | | 1 3.0|
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 38 |
Duct, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 2 2.5|
Metaplasia, Focal, Osseous | | 1 2.0|
Nephropathy | | 3 1.7|
Glomerulus, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Dilatation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + I + + + + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X |
Fatty Change, Focal | 3 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia, Focal | |
Ulcer, Focal | 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + A + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 3 1 |
Degeneration, Focal | |
Hemorrhage, Focal | 2 2 1 2 |
Hypertrophy, Focal | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + M M + M + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | 2 |
Follicle, Dilatation, Focal | 4 |
Follicular Cell, Hyperplasia, Focal | 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + A + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X X X X|
Hematocyst | X X |
Mineralization, Focal | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 3 4 4 4 3 |
Ectopic Tissue, Focal | |
Endometrium, Hyperplasia, Cystic | 3 3 2 1 4 3 2 2 3 3 2 2 2 2 2 4 3 3 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + |
Lumbar, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + I + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition, Focal | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
Inflammation, Chronic Active, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | |
Arteriole, Hypertrophy, Focal | |
Interstitium, Inflammation, Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + M + + + + + + + + + M + + M M + + + + M + + M M|
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Chronic, Focal | 3 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Nephropathy | 1 2 |
Renal Tubule, Dilatation, Focal | 4 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X X|
Fatty Change, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Ulcer, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Degeneration, Focal | 2 |
Hemorrhage, Focal | 2 2 3 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | |
Follicle, Dilatation, Focal | |
Follicular Cell, Hyperplasia, Focal | 2 1 2 3 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | X X X X X X X X |
Hematocyst | X |
Mineralization, Focal | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 3 4 3 3 3 3 3 |
Ectopic Tissue, Focal | X |
Endometrium, Hyperplasia, Cystic | 3 4 1 3 2 2 2 2 2 2 3 2 3 1 3 1 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 3 3 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition, Focal | 2 |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 1 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 3 |
Inflammation, Chronic Active, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 2 2 2 2 1 1 1 2 2 1 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Focal | 2 |
Arteriole, Hypertrophy, Focal | 2 |
Interstitium, Inflammation, Focal | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | M + M + + M M + + + + + + + + M + + + + + + + +|
Inflammation, Acute, Focal | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Chronic, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 3 3 |
Nephropathy | 1 1 1 |
Renal Tubule, Dilatation, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 49 |
__________________________________________________________________________|____________|
Gallbladder | | 46 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 48 |
__________________________________________________________________________|____________|
Liver | | 49 |
Basophilic Focus | | 6 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | | 11 |
Fatty Change, Focal | | 1 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | | 48 |
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 48 |
Hyperplasia, Focal | | 1 2.0|
Ulcer, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 48 |
Cytoplasmic Alteration, Focal | | 4 2.0|
Degeneration, Focal | | 1 2.0|
Hemorrhage, Focal | | 7 2.0|
Hypertrophy, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | | 48 |
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | | 7 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Inflammation, Chronic Active, Focal | | 1 2.0|
Follicle, Dilatation, Focal | | 1 4.0|
Follicular Cell, Hyperplasia, Focal | | 7 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 48 |
Angiectasis | | 1 3.0|
Cyst | | 15 |
Hematocyst | | 3 |
Mineralization, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | | 49 |
Dilatation | | 15 3.4|
Ectopic Tissue, Focal | | 1 |
Endometrium, Hyperplasia, Cystic | | 38 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
__________________________________________________________________________|____________|
Lymph Node | | 8 |
Lumbar, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Cyst | | 2 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 4 2.8|
Hyperplasia, Plasma Cell | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 47 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 49 |
Amyloid Deposition, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | | 3 2.3|
Hyperplasia, Lymphoid | | 10 1.8|
__________________________________________________________________________|____________|
Thymus | | 48 |
Hyperplasia, Lymphoid | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
__________________________________________________________________________|____________|
Skin | | 49 |
Inflammation, Acute, Focal | | 1 3.0|
Inflammation, Chronic Active, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
Mineralization, Focal | | 34 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 49 |
Congestion | | 1 2.0|
Hemorrhage, Focal | | 1 2.0|
Arteriole, Hypertrophy, Focal | | 1 2.0|
Interstitium, Inflammation, Focal | | 3 1.0|
__________________________________________________________________________|____________|
Nose | | 49 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 37 |
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Infarct, Chronic, Focal | | 1 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 2 3.0|
Nephropathy | | 5 1.2|
Renal Tubule, Dilatation, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 48 |
Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 0| 4| 4| 4| 4| 4|
| 9| 9| 9| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 0| 2| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + A + + + + + + M + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + A + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Clear Cell Focus | X X X X X X X X |
Eosinophilic Focus | X X X X X X X X X X |
Fatty Change, Focal | 2 |
Necrosis, Focal | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Acinar Cell, Atrophy | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Ulcer, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cytoplasmic Alteration, Focal | 2 |
Degeneration, Focal | 2 |
Hemorrhage, Focal | 2 |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +|
Degeneration, Focal | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + M + + + M M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + M + + + +|
Pars Distalis, Cyst | X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 0| 4| 4| 4| 4| 4|
| 9| 9| 9| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 0| 2| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
Follicular Cell, Hyperplasia, Focal | 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Inflammation, Chronic Active | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X 1 1 X X X X X X X X X|
Ectopic Tissue | |
Hematocyst | X |
Hyperplasia, Tubular | |
Infiltration Cellular, Focal, | |
Lymphocyte | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 2 2 2 2 2 |
Endometrium, Hyperplasia, Cystic | 2 4 2 2 2 3 2 2 2 3 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + M +|
Hemorrhage | |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Plasma Cell | 2 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 0| 4| 4| 4| 4| 4|
| 9| 9| 9| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 0| 2| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Atrophy | |
Cyst | |
Depletion Lymphoid | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 2 2 2 2 2 2 1 2 2 2 2 1 1 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hemorrhage, Multifocal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + M + + + + M M M + + + M + + M + + + + + + + M M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Chronic, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 3 |
Metaplasia, Focal, Osseous | 2 |
Nephropathy | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 4| 4| 4| 4| 8| 4| 4| 4| 0| 4| 4| 4| 4| 1| 4| 3| 2| 9| 4| 4| 4| 3| 4| 4|
| 7| 2| 2| 2| 2| 9| 2| 2| 2| 8| 2| 2| 2| 2| 5| 2| 8| 1| 4| 2| 2| 2| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + + + + M + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X X X X X X X X X |
Fatty Change, Focal | 2 |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 |
Acinar Cell, Atrophy | 3 3 |
Duct, Dilatation | 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Ulcer, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + M + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Cytoplasmic Alteration, Focal | |
Degeneration, Focal | |
Hemorrhage, Focal | |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + M + + + + + + + + + M + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 4| 4| 4| 4| 8| 4| 4| 4| 0| 4| 4| 4| 4| 1| 4| 3| 2| 9| 4| 4| 4| 3| 4| 4|
| 7| 2| 2| 2| 2| 9| 2| 2| 2| 8| 2| 2| 2| 2| 5| 2| 8| 1| 4| 2| 2| 2| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1|
Follicular Cell, Hyperplasia, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Inflammation, Chronic Active | 2 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 |
Cyst | X X X X X X X X X X X X 1 1|
Ectopic Tissue | X |
Hematocyst | X |
Hyperplasia, Tubular | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3|
Endometrium, Hyperplasia, Cystic | 1 2 2 3 3 3 2 3 2 2 3 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hyperplasia, Plasma Cell | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + M + + + + + + + + + + + + + +|
Cyst | X X |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 4| 4| 4| 4| 8| 4| 4| 4| 0| 4| 4| 4| 4| 1| 4| 3| 2| 9| 4| 4| 4| 3| 4| 4|
| 7| 2| 2| 2| 2| 9| 2| 2| 2| 8| 2| 2| 2| 2| 5| 2| 8| 1| 4| 2| 2| 2| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + M + + + + + +|
Atrophy | 3 |
Cyst | X |
Depletion Lymphoid | 3 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 2 1 2 2 2 2 2 2 2 3 2 1 2 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Multifocal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + M + + + + + + M + + + M + M + + M M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Chronic, Focal | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Metaplasia, Focal, Osseous | 1 |
Nephropathy | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | 3 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 48 |
__________________________________________________________________________|____________|
Gallbladder | | 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 45 |
__________________________________________________________________________|____________|
Liver | | 49 |
Basophilic Focus | | 7 |
Clear Cell Focus | | 12 |
Eosinophilic Focus | | 21 |
Fatty Change, Focal | | 2 2.0|
Necrosis, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Necrosis, Focal | | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Fibrosis, Focal | | 1 3.0|
Acinar Cell, Atrophy | | 2 3.0|
Duct, Dilatation | | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Hyperplasia, Focal | | 2 1.5|
Ulcer, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 48 |
Cyst | | 3 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Degeneration, Focal | | 1 2.0|
Hemorrhage, Focal | | 1 2.0|
Hypertrophy, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | | 47 |
Degeneration, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | | 45 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
C-Cell, Hyperplasia, Focal | | 1 1.0|
Follicular Cell, Hyperplasia, Focal | | 6 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Inflammation, Chronic Active | | 1 2.0|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | | 49 |
Angiectasis | | 3 2.3|
Cyst | | 28 1.0|
Ectopic Tissue | | 1 |
Hematocyst | | 2 |
Hyperplasia, Tubular | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | | 49 |
Dilatation | | 9 2.3|
Endometrium, Hyperplasia, Cystic | | 31 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Angiectasis, Focal | | 1 2.0|
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 7 |
Iliac, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Plasma Cell | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 47 |
Cyst | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Plasma Cell | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 46 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 1.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 49 |
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | | 6 2.3|
Hyperplasia, Lymphoid | | 5 2.2|
__________________________________________________________________________|____________|
Thymus | | 46 |
Atrophy | | 1 3.0|
Cyst | | 1 |
Depletion Lymphoid | | 1 3.0|
Necrosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 48 |
__________________________________________________________________________|____________|
Skin | | 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
Mineralization, Focal | | 38 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 49 |
Congestion | | 1 1.0|
Hemorrhage, Multifocal | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.0|
__________________________________________________________________________|____________|
Nose | | 49 |
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 32 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Infarct, Chronic, Focal | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 3.0|
Metaplasia, Focal, Osseous | | 2 1.5|
Nephropathy | | 3 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Inflammation, Chronic Active, Focal | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 1| 1| 3| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 3| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + M + + + + + + + + M M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X|
Clear Cell Focus | X X |
Developmental Malformation | X |
Eosinophilic Focus | X X X X X |
Infarct, Chronic | |
Inflammation, Chronic, Focal | 2 |
Leukocytosis | |
Mixed Cell Focus | X |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 2 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic Active, Focal | |
Ulcer, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M M + M + + + + + + + M M + + + + + + +|
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 1| 1| 3| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 3| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Duct, Dilatation | 3 3 3 3 2 3 3 3 3 4 3 3 2 3 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 3 |
Seminiferous Tubule, Degeneration, | |
Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + |
Bronchial, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + M + + + + + + + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + A + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Plasma Cell | |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 3 |
Lymphocyte, Necrosis, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | X |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M M M M I M M I I M M|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 1| 1| 3| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 3| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Mineralization, Focal | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukocytosis | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Interstitium, Inflammation, Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Middle Ear, Inflammation, Chronic | |
Active, Focal | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + M + + M + + + + + + + + + M M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 2 1 1 1 1 2 2 2|
Renal Tubule, Dilatation, Focal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Transitional Epithelium, Hyperplasia,| |
Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X X X |
Developmental Malformation | |
Eosinophilic Focus | X X X X X X X X |
Infarct, Chronic | 3 |
Inflammation, Chronic, Focal | |
Leukocytosis | 2 |
Mixed Cell Focus | X X |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Inflammation, Chronic Active, Focal | 2 |
Ulcer, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + M + + + + + M +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 3 |
Duct, Dilatation | 3 2 3 2 3 2 3 3 3 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 |
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | |
Seminiferous Tubule, Degeneration, | |
Focal | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Bronchial, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 3 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Lymphoid | 2 |
Lymphocyte, Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Mineralization, Focal | 2 1 2 2 1 2 2 2 1 2 2 2 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukocytosis | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 1 2 |
Interstitium, Inflammation, Focal | 2 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Middle Ear, Inflammation, Chronic | |
Active, Focal | 3 |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + M + + + + + + + + + M + + M + + M + + + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 1 1 1 1 2 2 1 1 1 1 3 1 |
Renal Tubule, Dilatation, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Transitional Epithelium, Hyperplasia,| |
Focal | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 7| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 49 |
__________________________________________________________________________|____________|
Gallbladder | | 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 49 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 7 |
Clear Cell Focus | | 8 |
Developmental Malformation | | 1 |
Eosinophilic Focus | | 13 |
Infarct, Chronic | | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
Leukocytosis | | 1 2.0|
Mixed Cell Focus | | 3 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis, Focal | | 3 1.7|
__________________________________________________________________________|____________|
Pancreas | | 49 |
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic Active, Focal | | 1 2.0|
Ulcer, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 50 |
Hyperplasia, Focal | | 1 3.0|
Hypertrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 41 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 7| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicular Cell, Hyperplasia, Focal | | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
Granuloma Sperm | | 2 2.5|
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 29 |
Inflammation, Chronic Active | | 2 3.0|
Duct, Dilatation | | 27 2.9|
__________________________________________________________________________|____________|
Prostate | | 50 |
Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Dilatation | | 2 1.5|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Degeneration, Focal | | 1 3.0|
Seminiferous Tubule, Degeneration, | | |
Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 4 |
Bronchial, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 46 |
Hyperplasia, Lymphoid | | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 48 |
Hemorrhage | | 3 2.3|
Hyperplasia, Lymphoid | | 2 3.5|
Hyperplasia, Plasma Cell | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 7| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | | 49 |
Hematopoietic Cell Proliferation | | 3 2.7|
Hyperplasia, Lymphoid | | 2 2.5|
Lymphocyte, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 49 |
Cyst | | 2 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 1 |
__________________________________________________________________________|____________|
Skin | | 50 |
Inflammation, Chronic Active, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hemorrhage, Focal | | 1 2.0|
Mineralization, Focal | | 36 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Leukocytosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 5 1.8|
Interstitium, Inflammation, Focal | | 4 1.5|
__________________________________________________________________________|____________|
Nose | | 50 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Middle Ear, Inflammation, Chronic | | |
Active, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 39 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 7| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Nephropathy | | 25 1.4|
Renal Tubule, Dilatation, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Dilatation | | 1 3.0|
Transitional Epithelium, Hyperplasia,| | |
Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + A + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X |
Clear Cell Focus | X X |
Cytomegaly, Focal | |
Eosinophilic Focus | X X X X|
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | |
Mixed Cell Focus | X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Ulcer, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia, Focal | 3 2 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Nervosa, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 2 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Duct, Dilatation | 2 3 2 4 3 3 2 3 3 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hyperplasia, Focal | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 1 3 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M M + + + + + + + M + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M M M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 2 1 2 2 2 2 2 2 2 1 2 2 1 2 2 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 |
Interstitium, Inflammation, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cornea, Inflammation, Chronic | 3 |
Lens, Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Zymbal's Gland | M + + + + + M M + + + + M + + + + + M M + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 2 2 1 1 1 1 1 1 1 1 2|
Renal Tubule, Dilatation, Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M + M M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X |
Clear Cell Focus | X X X |
Cytomegaly, Focal | 2 |
Eosinophilic Focus | X X X X X X X X|
Fatty Change, Focal | 1 |
Hematopoietic Cell Proliferation | 3 |
Mixed Cell Focus | X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Atrophy | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 |
Ulcer, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M + M M + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Cyst | X |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic, Focal | 2 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Duct, Dilatation | 3 3 2 3 3 3 3 3 3 2 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + M + + + + + + +|
Dilatation | |
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hematopoietic Cell Proliferation | 2 2 2 |
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + M + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 2 1 2 2 1 2 2 2 1 2 2 1 2 2 2 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Interstitium, Inflammation, Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + M + M M M + + + + + M + + M M + M + + + + + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1|
Renal Tubule, Dilatation, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Diverticulum | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 48 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 49 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | | 5 |
Clear Cell Focus | | 5 |
Cytomegaly, Focal | | 1 2.0|
Eosinophilic Focus | | 12 |
Fatty Change, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Mixed Cell Focus | | 5 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinar Cell, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia, Focal | | 3 2.7|
Ulcer, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 50 |
Accessory Adrenal Cortical Nodule | | 1 |
Hyperplasia, Focal | | 2 2.5|
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
Pars Distalis, Cyst | | 2 |
Pars Nervosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicular Cell, Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
Granuloma Sperm | | 2 2.0|
Inflammation, Chronic, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 23 |
Duct, Dilatation | | 23 2.8|
__________________________________________________________________________|____________|
Prostate | | 49 |
Dilatation | | 1 2.0|
Hyperplasia, Focal | | 4 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Atrophy, Focal | | 1 2.0|
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Angiectasis, Focal | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 4 2.3|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 49 |
Hemorrhage | | 3 2.3|
Hyperplasia, Lymphoid | | 4 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Developmental Malformation | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 3 2.0|
Hyperplasia, Lymphoid | | 4 2.0|
__________________________________________________________________________|____________|
Thymus | | 45 |
Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 2 |
__________________________________________________________________________|____________|
Skin | | 50 |
Inflammation, Chronic Active, Focal | | 3 2.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Mineralization, Focal | | 42 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Infiltration Cellular, Focal, | | |
Histiocyte | | 2 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.0|
Interstitium, Inflammation, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic | | 1 3.0|
Lens, Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 4 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 34 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Nephropathy | | 20 1.2|
Renal Tubule, Dilatation, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 2| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 4| 8| 8| 8| 2| 8| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + I + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X X |
Fatty Change, Focal | 1 1 2 |
Inflammation, Chronic, Focal | 2 |
Leukocytosis | |
Mixed Cell Focus | |
Necrosis, Focal | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2|
Ulcer, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
Inflammation, Chronic Active, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + I + + + + + + + + + + + + M +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + M + +|
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 2| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 4| 8| 8| 8| 2| 8| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Dilatation, Focal | 2 |
Follicular Cell, Hypertrophy, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Inflammation, Chronic Active | 3 |
Duct, Dilatation | 3 3 3 4 3 3 3 3 2 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Degeneration, Focal | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M I M I M M M M M M + + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 2| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 4| 8| 8| 8| 2| 8| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Mineralization, Focal | 2 2 2 2 2 1 1 2 2 2 1 2 2 2 1 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Histiocyte | 1 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 2 |
Interstitium, Inflammation, Focal | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + M + + M + M + + M + + + + +|
Inflammation, Chronic Active | |
Duct, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Chronic, Focal | 2 |
Mineralization, Focal | 1 |
Nephropathy | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 3 1|
Renal Tubule, Dilatation, Focal | 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
| 8| 8| 8| 0| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X |
Fatty Change, Focal | |
Inflammation, Chronic, Focal | |
Leukocytosis | 2 |
Mixed Cell Focus | X X |
Necrosis, Focal | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Ulcer, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 3 |
Inflammation, Chronic Active, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + M + + M M + + M + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
| 8| 8| 8| 0| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Dilatation, Focal | |
Follicular Cell, Hypertrophy, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 |
Duct, Dilatation | 4 3 2 2 3 3 3 3 2 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Degeneration, Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 3 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M M + + + + + + + + + + + + +|
Cyst | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
| 8| 8| 8| 0| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Mineralization, Focal | 2 2 2 2 1 2 2 2 2 1 1 2 2 2 1 1 1 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Histiocyte | |
Leukocytosis | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Interstitium, Inflammation, Focal | 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | M + + + + + + + + + M + + + + M + M + + + + + + +|
Inflammation, Chronic Active | 2 |
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Chronic, Focal | 2 |
Mineralization, Focal | |
Nephropathy | 1 1 1 1 1 1 1 2 1 2 1 1 1|
Renal Tubule, Dilatation, Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 47 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | | 4 |
Clear Cell Focus | | 5 |
Eosinophilic Focus | | 10 |
Fatty Change, Focal | | 3 1.3|
Inflammation, Chronic, Focal | | 1 2.0|
Leukocytosis | | 1 2.0|
Mixed Cell Focus | | 2 |
Necrosis, Focal | | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia, Focal | | 1 2.0|
Ulcer, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Inflammation, Acute, Focal | | 1 3.0|
Inflammation, Chronic Active, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 50 |
Hyperplasia, Focal | | 2 2.0|
Hypertrophy, Focal | | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | | 50 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | | 42 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
Pars Distalis, Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicle, Dilatation, Focal | | 1 2.0|
Follicular Cell, Hypertrophy, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
__________________________________________________________________________|____________|
Preputial Gland | | 23 |
Inflammation, Chronic Active | | 2 3.0|
Duct, Dilatation | | 22 2.9|
__________________________________________________________________________|____________|
Prostate | | 50 |
Hyperplasia, Focal | | 6 1.2|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Angiectasis, Focal | | 1 2.0|
Degeneration, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Cyst | | 1 |
Hyperplasia, Lymphoid | | 4 2.5|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 50 |
Hemorrhage | | 2 3.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 3 2.7|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | | 46 |
Cyst | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 3 |
__________________________________________________________________________|____________|
Skin | | 50 |
Subcutaneous Tissue, Abscess | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hemorrhage, Focal | | 1 2.0|
Mineralization, Focal | | 43 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Infiltration Cellular, Focal, | | |
Histiocyte | | 1 1.0|
Leukocytosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 3 1.7|
Interstitium, Inflammation, Focal | | 3 1.3|
__________________________________________________________________________|____________|
Nose | | 50 |
Inflammation, Acute, Focal | | 3 1.3|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 4 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 42 |
Inflammation, Chronic Active | | 1 2.0|
Duct, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Infarct, Chronic, Focal | | 2 2.0|
Mineralization, Focal | | 1 1.0|
Nephropathy | | 30 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Dilatation, Focal | | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Acute, Focal | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X X X X X X X X X X|
Fatty Change, Focal | 2 2 |
Mixed Cell Focus | |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hemorrhage, Focal | |
Hyperplasia, Focal | 1 2 |
Hypertrophy, Focal | 2 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + M + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Dilatation, Focal | |
Follicular Cell, Hyperplasia, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + +|
Inflammation, Chronic Active | |
Duct, Dilatation | 3 3 3 3 2 2 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
__________________________________________________________________________|
Lymph Node | |
Mediastinal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + M + + + + + + M + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M + M + M M M + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 1 2 2 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Interstitium, Inflammation, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 3|
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | |
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + + + M + M + + + + M M + + + + M + + + + + M M|
Duct, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | |
Nephropathy | 1 2 1 1 2 1 |
Renal Tubule, Dilatation, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3|
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M M +|
Hyperplasia | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X X X X X X X|
Fatty Change, Focal | 2 1 |
Mixed Cell Focus | X |
Necrosis, Focal | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage, Focal | 2 |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + M + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + M + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Dilatation, Focal | 2 |
Follicular Cell, Hyperplasia, Focal | 3 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3|
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 |
Duct, Dilatation | 3 2 3 3 3 3 3 3 3 3 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Congestion | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | X |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 |
__________________________________________________________________________|
Thymus | + + M + + M + + + + M + + + + M + + + + M + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M I M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 1 2 2 2 2 2 2 2 2 1 1 2 2 2 2 2 1 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Interstitium, Inflammation, Focal | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3|
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 3 |
Inflammation, Acute, Focal | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | M + + M + + + + + + + M + + + + + + M M + M + + +|
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | 2 |
Nephropathy | 1 2 1 1 1 2 1 2 1 1 1 1 1|
Renal Tubule, Dilatation, Focal | 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | 1 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 47 |
Hyperplasia | | 1 3.0|
Inflammation, Acute | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
Inflammation, Acute, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 48 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 9 |
Clear Cell Focus | | 4 |
Eosinophilic Focus | | 28 |
Fatty Change, Focal | | 4 1.8|
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinar Cell, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 50 |
Atrophy | | 1 3.0|
Hemorrhage, Focal | | 1 2.0|
Hyperplasia, Focal | | 3 1.7|
Hypertrophy, Focal | | 4 2.3|
__________________________________________________________________________|____________|
Adrenal Medulla | | 50 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 43 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicle, Dilatation, Focal | | 1 2.0|
Follicular Cell, Hyperplasia, Focal | | 5 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ductus Deferens | | 1 |
__________________________________________________________________________|____________|
Epididymis | | 50 |
__________________________________________________________________________|____________|
Preputial Gland | | 21 |
Inflammation, Chronic Active | | 1 3.0|
Duct, Dilatation | | 21 2.8|
__________________________________________________________________________|____________|
Prostate | | 50 |
Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
__________________________________________________________________________|____________|
Testes | | 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Angiectasis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 3 |
Mediastinal, Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Cyst | | 1 |
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 4 2.3|
__________________________________________________________________________|____________|
Thymus | | 42 |
Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 4 |
__________________________________________________________________________|____________|
Skin | | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 16:32:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Mineralization, Focal | | 43 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Hemorrhage, Focal | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 1.5|
Interstitium, Inflammation, Focal | | 2 1.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Congestion | | 1 3.0|
Inflammation, Acute, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 37 |
Duct, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Metaplasia, Focal, Osseous | | 1 2.0|
Nephropathy | | 19 1.3|
Renal Tubule, Dilatation, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Metaplasia, Focal, Osseous | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
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