TDMS Study 05130-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/17/94
EXP: 05130 C. I. DIRECT BLUE 218 TIME: 00:05:11
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 60877B
CONT: NO1-ES-5096 CAS: 10401-500
PATHOLOGIST: L. BRENNECKE
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/17/94
EXP: 05130 C. I. DIRECT BLUE 218 TIME: 00:05:11
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 60877B
CONT: NO1-ES-5096 CAS: 10401-500
PATHOLOGIST: L. BRENNECKE
C. I. DIRECT BLUE 218
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 5 CENSORED DEATHS 11 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 388 519 613 667 676 |
| CENSORED DEATHS |
| 24 87 455 455 455 455 455 456 456 456 |
| 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPMLOW |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 4 CENSORED DEATHS 10 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 455 653 659 689 |
| CENSORED DEATHS |
| 455 455 455 455 455 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3000 PP ID |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 8 CENSORED DEATHS 10 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 511 622 646 650 655 686 702 704 |
| CENSORED DEATHS |
| 455 455 455 455 455 456 456 456 456 456 |
| |
==================================================================================
C. I. DIRECT BLUE 218
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 10000PPMHIGH |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 5 CENSORED DEATHS 10 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 568 576 660 675 716 |
| CENSORED DEATHS |
| 455 455 455 455 455 456 456 456 456 456 |
| |
==================================================================================
C. I. DIRECT BLUE 218
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 737 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.3 98.3 96.2 96.2 94.2 90.1 |
| | |
| | |
|1000 PPMLOW| 100.0 100.0 100.0 100.0 100.0 98.3 98.3 98.3 94.3 92.3 |
| | |
| | |
|3000 PP ID| 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 90.0 84.0 |
| | |
| | |
|10000PPMHIG| 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 94.0 90.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 1000 PPMLOW 3000 PP ID 10000PPMH|GH
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 90.1% 92.3% 84.0% 90.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.949N P=0.602 P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 572.6 614.0 647.0 639.0 |
|NATURAL DEATHS (C) | (53.9) (53.6) (22.0) (28.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 658.4 681.9 678.1 681.9 |
|(STANDARD ERROR) | (20.4) (14.1) (13.8) (13.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
C. I. DIRECT BLUE 218
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 739 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 12 CENSORED DEATHS 11 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 88 184 368 518 580 613 617 627 644 688 |
| 701 728 |
| CENSORED DEATHS |
| 43 455 455 455 455 455 456 456 456 456 |
| 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 PPMLOW |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 522 554 590 639 639 648 648 669 679 693 |
| CENSORED DEATHS |
| 455 455 455 455 455 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3000 PP ID |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 3 CENSORED DEATHS 11 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 532 676 704 |
| CENSORED DEATHS |
| 455 455 455 455 455 456 456 456 456 456 |
| 470 |
| |
==================================================================================
C. I. DIRECT BLUE 218
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 739 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 10000PPMHIGH |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 12 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 108 427 504 541 567 689 694 700 715 721 |
| CENSORED DEATHS |
| 38 455 455 455 455 455 456 456 456 456 |
| 456 539 |
| |
==================================================================================
C. I. DIRECT BLUE 218
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 739 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 739 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.3 98.3 96.6 96.6 94.9 94.9 92.9 90.8 82.5 76.3 |
| | |
| | |
|1000 PPMLOW| 100.0 100.0 100.0 100.0 100.0 100.0 98.0 94.0 86.0 80.0 |
| | |
| | |
|3000 PP ID| 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 98.0 93.9 |
| | |
| | |
|10000PPMHIG| 100.0 98.3 98.3 98.3 98.3 96.6 92.5 90.4 90.4 79.8 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 1000 PPMLOW 3000 PP ID 10000PPMH|GH
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.3% 80.0% 93.9% 79.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000N P=0.695N P=0.022N P=0.792N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 529.7 628.1 637.3 566.6 |
|NATURAL DEATHS (C) | (59.9) (17.5) (53.3) (60.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 638.3 673.3 682.2 648.0 |
|(STANDARD ERROR) | (21.8) (14.0) (14.4) (20.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
C. I. DIRECT BLUE 218
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
1000 PPMLOW = 2
3000 PP ID = 3
10000PPMHIGH = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3 4
|
|
| 1 2 1 2
98 + 3 44 3
|
|
| 2 2
P 96 + 1 4 13 3 4
E |
R |
C | 2 2
E 94 + 1 414
N |
T |
| 2 2
S 92 + 33 11 4
U |
R |
V |
I 90 + 3 13 4 1
V |
A |
L |
88 + 3 3
|
|
|
86 +
|
|
|
84 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
C. I. DIRECT BLUE 218
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
1000 PPMLOW = 2
3000 PP ID = 3
10000PPMHIGH = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100.0 +1 1 4 23
|
|
| 1 4 1 4 23 2 3
97.5 +
| 1 1 4 4
| 2 2
| 3 3
95.0 + 1 1
| 4 4
| 2 2 3 3
| 1 1
P 92.5 + 4 4
E |
R |
C | 4 1 1 4
E 90.0 + 22
N |
T | 11
| 44
S 87.5 +
U | 11
R | 2 2
V |
I 85.0 +
V | 1 1
A | 22 4 4
L |
82.5 + 1 1
| 2 2
|
| 1 1
80.0 + 2 4 2
|
|
| 1 1
77.5 +
|
| 1 1
|
75.0 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.