TDMS Study 05130-03 Pathology Tables
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
Facility: Microbiological Associates
Chemical CAS #: 10401-500
Lock Date: 11/21/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 5| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 7| 3| 3| 7| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 7| 3| 2| 3| 6| 3| 3|
| 3| 4| 2| 1| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 0| 4| 8| 4| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Mineralization, Focal | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X |
Congestion | 3 2 |
Degeneration, Cystic, Focal | 1 |
Developmental Malformation | |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 4 |
Fatty Change, Focal | 1 1 2 1 1 2 2 1 2|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | 2 |
Inflammation, Chronic, Focal | 2 1 2 2 |
Inflammation, Focal, Granulomatous | |
Mixed Cell Focus | |
Bile Duct, Hyperplasia, Focal | 2 1|
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis, Focal | 3 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 2 1 1 1 2 2 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 3 |
Hyperplasia, Basal Cell, Focal | 2 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 3 |
Ulcer, Focal | 4 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 1 |
Inflammation, Chronic Active, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 5| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 7| 3| 3| 7| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 7| 3| 2| 3| 6| 3| 3|
| 3| 4| 2| 1| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 0| 4| 8| 4| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 2 1 1 2 1 1 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Hyperplasia, Focal | 3 |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Focal | 3 2 1 2 2 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M M + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 2 |
Pars Distalis, Cyst | 2 2 2 |
Pars Distalis, Hyperplasia, Focal | 3 2 2 3 1 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
C-Cell, Hyperplasia, Diffuse | 2 |
C-Cell, Hyperplasia, Focal | 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 2 |
Duct, Dilatation | 3 2 3 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Cyst, Multiple | 3 3 |
Dilatation | |
Hypoplasia | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 5| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 7| 3| 3| 7| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 7| 3| 2| 3| 6| 3| 3|
| 3| 4| 2| 1| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 0| 4| 8| 4| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hemorrhage | |
Renal, Hemorrhage | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 1 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 |
Galactocele | 3 3 2 3 2 2 2 2 1 |
Hyperplasia, Focal | |
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic, Focal | 3 |
Duct, Dilatation | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 3 2 |
Inflammation, Acute | |
Femur, Osteoporosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Ectopic Tissue | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage, Focal | 1 |
Infiltration Cellular, Focal, | |
Histiocyte | 2 1 1 1 1 |
Inflammation, Focal | 2 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 5| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 2| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 7| 3| 3| 7| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 7| 3| 2| 3| 6| 3| 3|
| 3| 4| 2| 1| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 0| 4| 8| 4| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Hemorrhage | |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 2 3 2 |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | 4 |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + M + + M + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Mineralization, Focal | 1 2 1 2 1 2 2 1 1 1 1 1 1 1 2 1 1 1 1|
Nephropathy | 2 1 4 3 2 1 2 1 1 2 1 2 1 2 2 2 2 2 1|
Pigmentation, Focal | 1 1 1 3 1 2 1 1 1 1 1 3 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 3| 3| 1| 6| 3|
| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Congestion | |
Degeneration, Cystic, Focal | 2 |
Developmental Malformation | X |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 3 4 3 |
Fatty Change, Focal | 2 1 2 2 3 |
Hematopoietic Cell Proliferation | 1 1 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2 2 3 |
Inflammation, Chronic, Focal | 2 1 1 2 1 1 1 |
Inflammation, Focal, Granulomatous | 3 |
Mixed Cell Focus | X X |
Bile Duct, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis, Focal | 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 4 |
Acinus, Atrophy, Focal | 1 2 2 1 2 2 2 2|
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 2 |
Hyperplasia, Basal Cell, Focal | |
Inflammation, Acute, Focal | 2 3 |
Inflammation, Chronic, Focal | |
Ulcer, Focal | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Inflammation, Chronic Active, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 3| 3| 1| 6| 3|
| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 1 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2|
Hyperplasia, Focal | 2 2 2 |
Hypertrophy, Focal | 2 1 |
Vacuolization Cytoplasmic, Focal | 3 3 2 1 2 1 2 1 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Cyst | 3 2 3 3 2 3 2 |
Pars Distalis, Hyperplasia, Focal | 2 1 2 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
C-Cell, Hyperplasia, Diffuse | |
C-Cell, Hyperplasia, Focal | 2 1 1 1 1 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + M + + + + + + + + + +|
Inflammation, Chronic | 1 2 |
Inflammation, Suppurative | 3 3 |
Duct, Dilatation | 3 2 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 1 1|
Cyst, Multiple | |
Dilatation | 2 2 1 |
Hypoplasia | 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 3| 3| 1| 6| 3|
| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hemorrhage | 2 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | |
Galactocele | 2 3 2 2 |
Hyperplasia, Focal | 2 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 3|
Inflammation, Acute | 2 |
Femur, Osteoporosis | 4 |
__________________________________________________________________________|
Skeletal Muscle | |
Diaphragm, Ectopic Tissue | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | |
Infiltration Cellular, Focal, | |
Histiocyte | 1 1 1 1 1 |
Inflammation, Focal | 2 1 2 |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 6| 3| 3| 3| 3| 3| 1| 6| 3|
| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Hemorrhage | 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 2 2 3 |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + M + + + M + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Mineralization, Focal | 1 1 1 1 2 1 1 1 1 1 1 2 2 |
Nephropathy | 1 1 2 3 1 2 1 1 1 2 1 1 1 1 2 2 2 1 2 2|
Pigmentation, Focal | 2 2 1 1 2 1 2 1 1 1 2 1 1 2 1 2 2 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 48 |
Mineralization, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 48 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Focal | | 3 2.0|
Basophilic Focus | | 38 |
Clear Cell Focus | | 11 |
Congestion | | 2 2.5|
Degeneration, Cystic, Focal | | 2 1.5|
Developmental Malformation | | 1 |
Eosinophilic Focus | | 2 |
Fatty Change, Diffuse | | 4 3.5|
Fatty Change, Focal | | 14 1.6|
Hematopoietic Cell Proliferation | | 3 1.3|
Hepatodiaphragmatic Nodule | | 4 |
Hyperplasia, Focal | | 4 2.3|
Inflammation, Chronic, Focal | | 11 1.5|
Inflammation, Focal, Granulomatous | | 1 3.0|
Mixed Cell Focus | | 2 |
Bile Duct, Hyperplasia, Focal | | 3 1.7|
__________________________________________________________________________|____________|
Mesentery | | 8 |
Fat, Necrosis, Focal | | 8 2.9|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Atrophy, Diffuse | | 1 4.0|
Acinus, Atrophy, Focal | | 15 1.7|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Acanthosis, Focal | | 2 2.5|
Hyperplasia, Basal Cell, Focal | | 1 2.0|
Inflammation, Acute, Focal | | 2 2.5|
Inflammation, Chronic, Focal | | 1 3.0|
Ulcer, Focal | | 2 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Erosion, Focal | | 1 1.0|
Inflammation, Chronic Active, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 22 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 50 |
Angiectasis, Focal | | 2 2.0|
Hyperplasia, Focal | | 4 2.3|
Hypertrophy, Focal | | 2 1.5|
Vacuolization Cytoplasmic, Focal | | 18 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | | 49 |
Hyperplasia | | 7 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Angiectasis, Focal | | 1 2.0|
Pars Distalis, Cyst | | 10 2.4|
Pars Distalis, Hyperplasia, Focal | | 13 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Inflammation | | 1 3.0|
C-Cell, Hyperplasia, Diffuse | | 1 2.0|
C-Cell, Hyperplasia, Focal | | 10 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 47 |
Inflammation, Chronic | | 2 1.5|
Inflammation, Suppurative | | 3 2.7|
Duct, Dilatation | | 8 2.5|
__________________________________________________________________________|____________|
Ovary | | 50 |
Cyst | | 3 2.3|
__________________________________________________________________________|____________|
Uterus | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 5 1.6|
Cyst, Multiple | | 2 3.0|
Dilatation | | 3 1.7|
Hypoplasia | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Atrophy | | 7 2.1|
__________________________________________________________________________|____________|
Lymph Node | | 7 |
Mediastinal, Hemorrhage | | 1 2.0|
Renal, Hemorrhage | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Hemorrhage | | 3 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 50 |
Hemorrhage | | 6 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | | 48 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Degeneration, Focal | | 1 2.0|
Galactocele | | 13 2.2|
Hyperplasia, Focal | | 1 2.0|
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 1 3.0|
Duct, Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Hyperostosis | | 5 3.0|
Inflammation, Acute | | 1 2.0|
Femur, Osteoporosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Diaphragm, Ectopic Tissue | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hydrocephalus | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 3.0|
Hemorrhage, Focal | | 1 1.0|
Infiltration Cellular, Focal, | | |
Histiocyte | | 10 1.1|
Inflammation, Focal | | 9 1.3|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Fungus | | 1 3.0|
Hemorrhage | | 1 2.0|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic Active | | 6 2.3|
Inflammation, Subacute | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Phthisis Bulbi | | 1 4.0|
Retina, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 45 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Hemorrhage, Focal | | 1 1.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 1.0|
Mineralization, Focal | | 32 1.3|
Nephropathy | | 39 1.6|
Pigmentation, Focal | | 34 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 5| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 8| 1| 3| 4| 2| 2| 3|
| 2| 3| 3| 3| 3| 9| 3| 3| 3| 7| 3| 0| 3| 3| 0| 3| 3| 3| 1| 9| 3| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Congestion | 2 |
Developmental Malformation | 3 X |
Eosinophilic Focus | X X |
Fatty Change, Diffuse | 3 4 3 |
Fatty Change, Focal | 2 2 1 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage, Focal | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 2 |
Inflammation, Chronic, Focal | 1 2 1 1|
Inflammation, Focal, Granulomatous | 2 |
Mixed Cell Focus | |
Necrosis, Focal | 1 2 |
Bile Duct, Hyperplasia, Focal | |
Vein, Dilatation | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 2 1 1 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + M + + + + + +|
Acanthosis, Focal | |
Hyperplasia, Basal Cell, Focal | |
Inflammation, Chronic, Focal | |
Ulcer, Focal | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 2 2 2 1 1 |
Atrium, Thrombosis | 3 X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 5| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 8| 1| 3| 4| 2| 2| 3|
| 2| 3| 3| 3| 3| 9| 3| 3| 3| 7| 3| 0| 3| 3| 0| 3| 3| 3| 1| 9| 3| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 2 2|
Cyst | |
Degeneration, Cystic, Focal | 1 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 1 |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | 1 2 2 3 2 1 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Hyperplasia | 2 2 2 1 |
Bilateral, Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 3 3 2 2 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 1 3 3 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
C-Cell, Hyperplasia, Focal | 3 |
Follicle, Dilatation, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Dilatation | 3 3 2 2 3 2 3 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 3 X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 3 1 |
Cyst, Multiple | 2 2 |
Dilatation | 2 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 5| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 8| 1| 3| 4| 2| 2| 3|
| 2| 3| 3| 3| 3| 9| 3| 3| 3| 7| 3| 0| 3| 3| 0| 3| 3| 3| 1| 9| 3| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | 1 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst, Multiple | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 1 3 2 3 2 3 2 3 |
Hyperplasia, Focal | |
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hydrocephalus | 2 2 |
Inflammation, Focal | 3 |
Meninges, Angiectasis, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 1|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Focal, | |
Histiocyte | 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 5| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 8| 1| 3| 4| 2| 2| 3|
| 2| 3| 3| 3| 3| 9| 3| 3| 3| 7| 3| 0| 3| 3| 0| 3| 3| 3| 1| 9| 3| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Focal | 2 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | |
Inflammation, Acute | 3 2 1 |
Inflammation, Chronic Active | 2 3 2 3 |
Inflammation, Subacute | 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | 2 |
Bilateral, Lens, Cataract | |
Bilateral, Retina, Atrophy | |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + M + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization, Focal | 2 1 2 2 1 1 1 1 1 2 2 |
Nephropathy | 2 1 2 1 2 2 2 1 2 1 1 2 2 2 2 3 1|
Pigmentation, Focal | 1 1 2 1 2 3 1 1 1 3 1 |
Bilateral, Hydronephrosis | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 9| 2| 9| 1| 3| 8| 3| 5| 3| 3| 3| 8| 2| 7| 0|
| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 9| 6| 4| 3| 3| 4| 3| 9| 3| 3| 3| 4| 4| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
1000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | |
Congestion | |
Developmental Malformation | X X 2 |
Eosinophilic Focus | |
Fatty Change, Diffuse | 3 4 |
Fatty Change, Focal | 1 1 1 2 1 3 3 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage, Focal | 3 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | 1 2 1 2 2 |
Inflammation, Focal, Granulomatous | 3 |
Mixed Cell Focus | X X |
Necrosis, Focal | |
Bile Duct, Hyperplasia, Focal | 2 |
Vein, Dilatation | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 2 2 3 1 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 3 2 |
Hyperplasia, Basal Cell, Focal | 1 |
Inflammation, Chronic, Focal | 4 |
Ulcer, Focal | 4 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 1 1 1 1 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 9| 2| 9| 1| 3| 8| 3| 5| 3| 3| 3| 8| 2| 7| 0|
| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 9| 6| 4| 3| 3| 4| 3| 9| 3| 3| 3| 4| 4| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
1000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Cyst | 2 |
Degeneration, Cystic, Focal | 3 |
Hyperplasia, Focal | 1 1 3 |
Hypertrophy, Focal | 2 1 |
Vacuolization Cytoplasmic, Diffuse | 3 |
Vacuolization Cytoplasmic, Focal | 3 3 3 2 2 3 3 1 1 1 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 4 |
Hyperplasia | 1 |
Bilateral, Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + M + + + + + + + + + M M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + M + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 3 2 3 X|
Pars Distalis, Hyperplasia, Focal | 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
C-Cell, Hyperplasia, Focal | 1 1 1 |
Follicle, Dilatation, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + M + +|
Duct, Dilatation | 3 2 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 X 2 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 1 1 |
Cyst, Multiple | 3 |
Dilatation | 3 1 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 9| 2| 9| 1| 3| 8| 3| 5| 3| 3| 3| 8| 2| 7| 0|
| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 9| 6| 4| 3| 3| 4| 3| 9| 3| 3| 3| 4| 4| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
1000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Iliac, Hyperplasia, Plasma Cell | 2|
Mediastinal, Hemorrhage | 2 3 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 |
Hemorrhage | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 2 3 3 2 |
Hyperplasia, Focal | 2 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 |
Hydrocephalus | 1 3 2 3 |
Inflammation, Focal | |
Meninges, Angiectasis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Focal, | |
Histiocyte | 1 1|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 9| 2| 9| 1| 3| 8| 3| 5| 3| 3| 3| 8| 2| 7| 0|
| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 9| 6| 4| 3| 3| 4| 3| 9| 3| 3| 3| 4| 4| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
1000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Focal | 1 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | 3 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 3 |
Inflammation, Subacute | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | |
Bilateral, Lens, Cataract | 2 3 |
Bilateral, Retina, Atrophy | 3 2 |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + + + M + M + + + M + + + + + + M + + M M M + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Mineralization, Focal | 1 1 1 1 1 1 1 2 1 2 1 2 2 1|
Nephropathy | 2 2 1 1 3 1 1 1 2 2 2 1 3 1 2 1 1 2 2 2 2|
Pigmentation, Focal | 1 3 3 1 1 1 1 2 2 1 2 2 1|
Bilateral, Hydronephrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
1000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 46 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | | 28 |
Clear Cell Focus | | 4 |
Congestion | | 1 2.0|
Developmental Malformation | | 5 2.5|
Eosinophilic Focus | | 2 |
Fatty Change, Diffuse | | 5 3.4|
Fatty Change, Focal | | 11 1.7|
Hematopoietic Cell Proliferation | | 1 1.0|
Hemorrhage, Focal | | 1 3.0|
Hepatodiaphragmatic Nodule | | 4 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 9 1.4|
Inflammation, Focal, Granulomatous | | 2 2.5|
Mixed Cell Focus | | 2 |
Necrosis, Focal | | 2 1.5|
Bile Duct, Hyperplasia, Focal | | 1 2.0|
Vein, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Fat, Necrosis, Focal | | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | | 48 |
Acinus, Atrophy, Focal | | 9 1.8|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Acanthosis, Focal | | 2 2.5|
Hyperplasia, Basal Cell, Focal | | 1 1.0|
Inflammation, Chronic, Focal | | 1 4.0|
Ulcer, Focal | | 2 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
1000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 20 1.3|
Atrium, Thrombosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 50 |
Angiectasis, Focal | | 5 2.0|
Cyst | | 1 2.0|
Degeneration, Cystic, Focal | | 2 2.0|
Hyperplasia, Focal | | 3 1.7|
Hypertrophy, Focal | | 3 1.3|
Vacuolization Cytoplasmic, Diffuse | | 2 2.5|
Vacuolization Cytoplasmic, Focal | | 21 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | | 50 |
Degeneration | | 1 4.0|
Hyperplasia | | 5 1.6|
Bilateral, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Pars Distalis, Angiectasis | | 2 3.0|
Pars Distalis, Cyst | | 10 2.4|
Pars Distalis, Hyperplasia, Focal | | 9 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Inflammation | | 1 2.0|
C-Cell, Hyperplasia, Focal | | 4 1.5|
Follicle, Dilatation, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 48 |
Duct, Dilatation | | 12 2.5|
__________________________________________________________________________|____________|
Ovary | | 50 |
Cyst | | 9 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
1000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | | 50 |
Cyst | | 7 1.3|
Cyst, Multiple | | 3 2.3|
Dilatation | | 5 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Atrophy | | 4 1.8|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 12 |
Iliac, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Hemorrhage | | 2 2.5|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Cyst | | 3 1.7|
Hemorrhage | | 1 1.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 50 |
Hemorrhage | | 4 1.8|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 49 |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 49 |
Cyst, Multiple | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Galactocele | | 14 2.4|
Hyperplasia, Focal | | 1 2.0|
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Skin | | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Hyperostosis | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
1000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hemorrhage, Focal | | 1 1.0|
Hydrocephalus | | 6 2.2|
Inflammation, Focal | | 1 3.0|
Meninges, Angiectasis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Hemorrhage, Focal | | 3 1.3|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | | 7 1.0|
Inflammation, Focal | | 6 1.3|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 1 2.0|
Fungus | | 1 3.0|
Inflammation, Acute | | 3 2.0|
Inflammation, Chronic Active | | 6 2.5|
Inflammation, Subacute | | 5 1.8|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Hemorrhage | | 1 2.0|
Bilateral, Lens, Cataract | | 2 2.5|
Bilateral, Retina, Atrophy | | 2 2.5|
Lens, Cataract | | 1 3.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 41 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Cyst | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
1000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Mineralization, Focal | | 25 1.4|
Nephropathy | | 38 1.7|
Pigmentation, Focal | | 24 1.6|
Bilateral, Hydronephrosis | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 48 |
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 4| 5| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 3| 4| 3| 2| 0| 0| 8| 3| 3| 3| 8| 3| 3| 7| 3| 3| 3| 3| 3| 3| 1| 3|
| 0| 0| 0| 0| 0| 0| 8| 6| 6| 8| 0| 0| 0| 3| 0| 0| 4| 0| 0| 0| 0| 2| 0| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
3000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + I|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X |
Congestion | |
Cyst | |
Developmental Malformation | X |
Eosinophilic Focus | X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 2 1 2 2 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | 2 1 1 |
Inflammation, Focal, Granulomatous | |
Necrosis, Focal | 3 |
Bile Duct, Dilatation, Focal | 1|
Bile Duct, Hyperplasia, Focal | 2 |
Vein, Dilatation | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 2 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 2 |
Hyperplasia, Basal Cell, Focal | 1 1 1 |
Mineralization, Focal | 2 |
Ulcer, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Ulcer, Focal | |
__________________________________________________________________________|
Tongue | |
Acanthosis, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 2 1 1 2 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 4| 5| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 3| 4| 3| 2| 0| 0| 8| 3| 3| 3| 8| 3| 3| 7| 3| 3| 3| 3| 3| 3| 1| 3|
| 0| 0| 0| 0| 0| 0| 8| 6| 6| 8| 0| 0| 0| 3| 0| 0| 4| 0| 0| 0| 0| 2| 0| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
3000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 2 2 2 2 |
Cyst | 2 |
Degeneration, Cystic, Focal | 2 |
Hematopoietic Cell Proliferation, | |
Focal | 2 |
Hemorrhage | 2 |
Hyperplasia, Focal | 2 2 2 |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Focal | 3 1 1 2 1 1 1 2 1 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + M + M M + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 1 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
C-Cell, Hyperplasia, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | 3 |
Bilateral, Duct, Dilatation | |
Duct, Dilatation | 2 2 2 2 2 2 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 2 2 3 2 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 1 1 1 1|
Dilatation | 3 2 3 |
Inflammation, Acute | |
__________________________________________________________________________|
Vagina | + |
Cyst | 4 |
Hyperplasia, Focal, Squamous | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 4| 5| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 3| 4| 3| 2| 0| 0| 8| 3| 3| 3| 8| 3| 3| 7| 3| 3| 3| 3| 3| 3| 1| 3|
| 0| 0| 0| 0| 0| 0| 8| 6| 6| 8| 0| 0| 0| 3| 0| 0| 4| 0| 0| 0| 0| 2| 0| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
3000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + |
Axillary, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Hemorrhage | 2 1 |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 2 2 1 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hydrocephalus | 3 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | 2 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Focal, | |
Histiocyte | 2 1 1 1 1|
Inflammation, Focal | 2 2 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 4| 5| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 3| 4| 3| 2| 0| 0| 8| 3| 3| 3| 8| 3| 3| 7| 3| 3| 3| 3| 3| 3| 1| 3|
| 0| 0| 0| 0| 0| 0| 8| 6| 6| 8| 0| 0| 0| 3| 0| 0| 4| 0| 0| 0| 0| 2| 0| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
3000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | 3 2 2 |
Hemorrhage | |
Inflammation, Acute | 2 1 |
Inflammation, Chronic Active | 3 3 |
Inflammation, Subacute | 2 |
Goblet Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Inflammation, Acute | |
Bilateral, Lens, Cataract | 2 2 2 |
Bilateral, Retina, Atrophy | 3 3 3 |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | + + M + + M M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Cyst, Multiple | |
Mineralization, Focal | 1 2 2 1 2 2 2 1 1 1 1 2 1|
Nephropathy | 3 1 3 3 2 1 1 3 2 2 2 1 1 1 2 3 1 1 3 2 2|
Pigmentation, Focal | 2 2 2 2 2 2 3 2 1 1 1 1 2 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 8| 3| 2| 2| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 2| 7| 0| 6| 9| 0| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 9| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
3000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X|
Congestion | 2 3 2 |
Cyst | X |
Developmental Malformation | |
Eosinophilic Focus | X X |
Fatty Change, Diffuse | 3 3 |
Fatty Change, Focal | 3 2 1 1 2|
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal | 2 |
Inflammation, Chronic, Focal | 1 2 1 2 1 |
Inflammation, Focal, Granulomatous | 2 |
Necrosis, Focal | |
Bile Duct, Dilatation, Focal | |
Bile Duct, Hyperplasia, Focal | 1 |
Vein, Dilatation | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 3 |
Hyperplasia, Basal Cell, Focal | 1 1 |
Mineralization, Focal | |
Ulcer, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 |
Ulcer, Focal | 3 |
__________________________________________________________________________|
Tongue | + |
Acanthosis, Focal | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 2 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 8| 3| 2| 2| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 2| 7| 0| 6| 9| 0| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 9| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
3000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 2 2 1 2 2|
Cyst | |
Degeneration, Cystic, Focal | |
Hematopoietic Cell Proliferation, | |
Focal | |
Hemorrhage | |
Hyperplasia, Focal | 1 1 2 1|
Hypertrophy, Focal | 2 2 |
Vacuolization Cytoplasmic, Focal | 1 2 1 3 2|
__________________________________________________________________________|
Adrenal Medulla | M M + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 |
Bilateral, Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + M + + + + M M + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Pars Distalis, Cyst | 2 2 2 2 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 1 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 |
Inflammation, Suppurative | |
Bilateral, Duct, Dilatation | 3 |
Duct, Dilatation | 3 2 2 2 2 2 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 |
Dilatation | 2 2 2 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Vagina | + |
Cyst | 2 |
Hyperplasia, Focal, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 8| 3| 2| 2| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 2| 7| 0| 6| 9| 0| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 9| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
3000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + |
Axillary, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | 3 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | M M + + + + + + + M + + + + + + M M M + M + + + +|
Congestion | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 1 1 2 2 2 2|
Duct, Dilatation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 2 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Hemorrhage, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Infiltration Cellular, Focal, | |
Histiocyte | 1 1 |
Inflammation, Focal | 1 2 2 1 2 1 2|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 8| 3| 2| 2| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 2| 7| 0| 6| 9| 0| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 9| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
3000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | 3 3 2 |
Hemorrhage | 3 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 2 2 4 3 2 2 |
Inflammation, Subacute | 2 1 |
Goblet Cell, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Inflammation, Acute | 3 |
Bilateral, Lens, Cataract | |
Bilateral, Retina, Atrophy | |
Lens, Cataract | 2 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | 3 |
Cyst, Multiple | 3 |
Mineralization, Focal | 2 2 1 2 1 1 1 2 1 1 1 1 2 1 2|
Nephropathy | 1 1 2 1 3 2 1 1 2 3 1 1 2 1 2 2 3 1 1 2|
Pigmentation, Focal | 2 2 1 1 1 1 1 1 2 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
3000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 48 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 41 |
Clear Cell Focus | | 16 |
Congestion | | 3 2.3|
Cyst | | 1 |
Developmental Malformation | | 1 |
Eosinophilic Focus | | 3 |
Fatty Change, Diffuse | | 2 3.0|
Fatty Change, Focal | | 9 1.8|
Hepatodiaphragmatic Nodule | | 2 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 8 1.4|
Inflammation, Focal, Granulomatous | | 1 2.0|
Necrosis, Focal | | 1 3.0|
Bile Duct, Dilatation, Focal | | 1 1.0|
Bile Duct, Hyperplasia, Focal | | 2 1.5|
Vein, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Atrophy, Focal | | 9 1.7|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Acanthosis, Focal | | 3 2.0|
Hyperplasia, Basal Cell, Focal | | 5 1.0|
Mineralization, Focal | | 1 2.0|
Ulcer, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Erosion, Focal | | 1 2.0|
Ulcer, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Acanthosis, Focal | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
3000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 21 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 50 |
Angiectasis, Focal | | 13 1.9|
Cyst | | 1 2.0|
Degeneration, Cystic, Focal | | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Focal | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Focal | | 7 1.6|
Hypertrophy, Focal | | 2 2.0|
Vacuolization Cytoplasmic, Focal | | 16 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | | 47 |
Hyperplasia | | 6 2.0|
Bilateral, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Hemorrhage, Focal | | 1 2.0|
Pars Distalis, Cyst | | 7 2.1|
Pars Distalis, Hyperplasia, Focal | | 9 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
C-Cell, Hyperplasia, Focal | | 6 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 49 |
Hyperplasia | | 3 2.7|
Inflammation, Suppurative | | 1 3.0|
Bilateral, Duct, Dilatation | | 1 3.0|
Duct, Dilatation | | 15 2.1|
__________________________________________________________________________|____________|
Ovary | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
3000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Congestion | | 1 2.0|
Cyst | | 5 2.4|
__________________________________________________________________________|____________|
Uterus | | 50 |
Cyst | | 8 1.3|
Dilatation | | 6 2.3|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Vagina | | 2 |
Cyst | | 2 3.0|
Hyperplasia, Focal, Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Atrophy | | 10 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 6 |
Axillary, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Hemorrhage | | 3 2.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Hemorrhage | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 50 |
Hemorrhage | | 3 1.7|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | | 42 |
Congestion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Galactocele | | 10 1.7|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Hyperostosis | | 5 3.2|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
3000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage, Focal | | 2 2.0|
Hydrocephalus | | 3 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 2 2.5|
Hemorrhage, Focal | | 2 1.5|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 2 1.5|
Infiltration Cellular, Focal, | | |
Histiocyte | | 7 1.1|
Inflammation, Focal | | 11 1.6|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Fungus | | 6 2.5|
Hemorrhage | | 2 2.5|
Inflammation, Acute | | 2 1.5|
Inflammation, Chronic Active | | 9 2.6|
Inflammation, Subacute | | 3 1.7|
Goblet Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 6 |
Inflammation, Acute | | 1 3.0|
Bilateral, Lens, Cataract | | 3 2.0|
Bilateral, Retina, Atrophy | | 3 3.0|
Lens, Cataract | | 1 2.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 47 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Congestion | | 1 2.0|
Cyst | | 1 3.0|
Cyst, Multiple | | 1 3.0|
Mineralization, Focal | | 28 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
3000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | | 41 1.8|
Pigmentation, Focal | | 28 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 6| 5| 7| 7| 5| 6| 5| 7| 7| 6| 6| 6| 7| 2| 6| 7| 5|
DAY ON TEST | 2| 3| 2| 2| 2| 2| 7| 5| 7| 6| 2| 2| 9| 5| 5| 2| 2| 6| 3| 5| 1| 2| 4| 2| 5|
| 9| 7| 9| 9| 9| 9| 2| 8| 4| 0| 9| 9| 5| 8| 4| 9| 9| 5| 9| 8| 9| 6| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10000PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Degeneration, Cystic, Focal | 1 |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 3 |
Fatty Change, Focal | 2 2 1 1 1 2 3 2 2 1 1 2 2 2 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic, Focal | 1 1 |
Mixed Cell Focus | X |
Necrosis, Focal | 2 2 1|
Bile Duct, Hyperplasia, Focal | |
Centrilobular, Necrosis | 2 3 |
__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Necrosis, Focal | 2 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 2 2 1 2 2 2 2|
Acinus, Ectopic Liver, Focal | 2 |
Artery, Inflammation, Focal | 2 |
Duct, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Pharynx | + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 2 |
Hyperplasia, Basal Cell, Focal | 2 1 1 2 1 1 |
Inflammation, Chronic, Focal | 1 |
Ulcer, Focal | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 6| 5| 7| 7| 5| 6| 5| 7| 7| 6| 6| 6| 7| 2| 6| 7| 5|
DAY ON TEST | 2| 3| 2| 2| 2| 2| 7| 5| 7| 6| 2| 2| 9| 5| 5| 2| 2| 6| 3| 5| 1| 2| 4| 2| 5|
| 9| 7| 9| 9| 9| 9| 2| 8| 4| 0| 9| 9| 5| 8| 4| 9| 9| 5| 9| 8| 9| 6| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10000PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 2 2 2 |
Congestion | 2 |
Hyperplasia, Focal | 2 2 1 |
Hypertrophy, Focal | 1 2 1 |
Necrosis, Focal | 3 |
Vacuolization Cytoplasmic, Focal | 2 1 1 2 3 2 3 1 2 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Bilateral, Hyperplasia | 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + M + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 X X 2 3 2 |
Pars Distalis, Hyperplasia, Focal | 2 3 2 2 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 3 2 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + M + + + + + + + + + + +|
Hyperplasia | 3 3 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
Duct, Dilatation | 3 1 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Bilateral, Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
Cyst, Multiple | 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 2|
__________________________________________________________________________|
Lymph Node | + + + + + |
Axillary, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 6| 5| 7| 7| 5| 6| 5| 7| 7| 6| 6| 6| 7| 2| 6| 7| 5|
DAY ON TEST | 2| 3| 2| 2| 2| 2| 7| 5| 7| 6| 2| 2| 9| 5| 5| 2| 2| 6| 3| 5| 1| 2| 4| 2| 5|
| 9| 7| 9| 9| 9| 9| 2| 8| 4| 0| 9| 9| 5| 8| 4| 9| 9| 5| 9| 8| 9| 6| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10000PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hemorrhage | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + M + + + + + + +|
Hemorrhage | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 3 3 4 4 2 2 3 2 3|
Hyperplasia, Focal | 3 2 2 |
Inflammation, Acute, Focal | 3 |
Inflammation, Chronic, Focal | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 2 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 3 |
Infiltration Cellular, Focal, | |
Histiocyte | 1 1 1 1|
Inflammation, Focal | 2 1 2 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 6| 5| 7| 7| 5| 6| 5| 7| 7| 6| 6| 6| 7| 2| 6| 7| 5|
DAY ON TEST | 2| 3| 2| 2| 2| 2| 7| 5| 7| 6| 2| 2| 9| 5| 5| 2| 2| 6| 3| 5| 1| 2| 4| 2| 5|
| 9| 7| 9| 9| 9| 9| 2| 8| 4| 0| 9| 9| 5| 8| 4| 9| 9| 5| 9| 8| 9| 6| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10000PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Arteriole, Mineralization, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 3 3 3 3 2 |
Inflammation, Acute | 3 2 3 |
Inflammation, Chronic Active | 3 3 2 |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | M + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 1 1 3 2 2 1 1 2 2 2 2 1 1 2 2|
Nephropathy | 3 1 2 1 2 3 1 2 1 2 3 1 1 4 2 2 4 4 3|
Pigmentation, Focal | 2 2 2 2 2 3 2 2 2 2 2 2 2 3 2 3 2 2 2 3 2|
__________________________________________________________________________|
Urethra | |
Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 6| 7| 6| 4| 7| 7| 7| 7| 5| 6| 5| 7| 1| 7| 0| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 9| 2| 2| 2| 1| 2| 6| 8| 2| 2| 2| 2| 0| 6| 0| 2| 7| 0| 8| 2| 2| 2|
| 9| 9| 9| 6| 9| 9| 9| 8| 9| 0| 4| 9| 9| 9| 9| 2| 3| 2| 9| 6| 2| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
10000PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X|
Degeneration, Cystic, Focal | |
Eosinophilic Focus | X X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 2 2 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic, Focal | 2 1 1 2 1 1 1 1|
Mixed Cell Focus | X X X|
Necrosis, Focal | |
Bile Duct, Hyperplasia, Focal | 2 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +|
Accessory Spleen | |
Acinus, Atrophy, Diffuse | 4|
Acinus, Atrophy, Focal | 3 2 2 3 2 2 |
Acinus, Ectopic Liver, Focal | |
Artery, Inflammation, Focal | |
Duct, Hyperplasia, Focal | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
Acanthosis, Focal | 2|
Hyperplasia, Basal Cell, Focal | 2 1 2 1 1|
Inflammation, Chronic, Focal | |
Ulcer, Focal | 3 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 6| 7| 6| 4| 7| 7| 7| 7| 5| 6| 5| 7| 1| 7| 0| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 9| 2| 2| 2| 1| 2| 6| 8| 2| 2| 2| 2| 0| 6| 0| 2| 7| 0| 8| 2| 2| 2|
| 9| 9| 9| 6| 9| 9| 9| 8| 9| 0| 4| 9| 9| 9| 9| 2| 3| 2| 9| 6| 2| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
10000PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +|
Angiectasis, Focal | 3 1 2 |
Congestion | 2 |
Hyperplasia, Focal | 2 1 2|
Hypertrophy, Focal | 1 |
Necrosis, Focal | 3 |
Vacuolization Cytoplasmic, Focal | 2 2 2 1 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia | 1 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M + + + + + + + + + + M + + + + + + M|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + M + + A + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 3 3 3 2 2|
Pars Distalis, Hyperplasia, Focal | 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
C-Cell, Hyperplasia, Focal | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 2 |
Duct, Dilatation | 2 2 2 2 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 2 2 |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 1 |
Cyst, Multiple | 3 |
__________________________________________________________________________|
Vagina | + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + A + + +|
Atrophy | 2 2 3 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Axillary, Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 6| 7| 6| 4| 7| 7| 7| 7| 5| 6| 5| 7| 1| 7| 0| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 9| 2| 2| 2| 1| 2| 6| 8| 2| 2| 2| 2| 0| 6| 0| 2| 7| 0| 8| 2| 2| 2|
| 9| 9| 9| 6| 9| 9| 9| 8| 9| 0| 4| 9| 9| 9| 9| 2| 3| 2| 9| 6| 2| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
10000PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hemorrhage | 1 2 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Renal, Hemorrhage | 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3|
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + M + A + + +|
Hemorrhage | 2 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 2 2 X 2 1 2|
Hyperplasia, Focal | 2 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 1 |
Infiltration Cellular, Focal, | |
Histiocyte | 1 2 1 1 1 1 1 |
Inflammation, Focal | 1 1 1 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 6| 7| 6| 4| 7| 7| 7| 7| 5| 6| 5| 7| 1| 7| 0| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 9| 2| 2| 2| 1| 2| 6| 8| 2| 2| 2| 2| 0| 6| 0| 2| 7| 0| 8| 2| 2| 2|
| 9| 9| 9| 6| 9| 9| 9| 8| 9| 0| 4| 9| 9| 9| 9| 2| 3| 2| 9| 6| 2| 5| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
10000PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Arteriole, Mineralization, Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | 2 2 3|
Inflammation, Acute | |
Inflammation, Chronic Active | 3 2 3 2 2 3|
Inflammation, Subacute | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + M + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 2 2 2 2 3 1 1 2 1 2 1 2 2 1 2 2 2 |
Nephropathy | 1 2 1 1 2 3 2 2 1 3 1 1 3 2 2 3 2 2 1 2 3|
Pigmentation, Focal | 3 2 2 1 1 2 2 2 1 3 1 1 2 3 3 2 2 1 2 2 1|
__________________________________________________________________________|
Urethra | + |
Cyst | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
10000PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 46 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 30 |
Clear Cell Focus | | 12 |
Degeneration, Cystic, Focal | | 1 1.0|
Eosinophilic Focus | | 3 |
Fatty Change, Diffuse | | 1 3.0|
Fatty Change, Focal | | 18 1.7|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic, Focal | | 10 1.2|
Mixed Cell Focus | | 4 |
Necrosis, Focal | | 3 1.7|
Bile Duct, Hyperplasia, Focal | | 2 2.0|
Centrilobular, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Fat, Necrosis, Focal | | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | | 48 |
Accessory Spleen | | 1 |
Acinus, Atrophy, Diffuse | | 1 4.0|
Acinus, Atrophy, Focal | | 13 2.1|
Acinus, Ectopic Liver, Focal | | 1 2.0|
Artery, Inflammation, Focal | | 1 2.0|
Duct, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Acanthosis, Focal | | 3 1.7|
Hyperplasia, Basal Cell, Focal | | 11 1.4|
Inflammation, Chronic, Focal | | 1 1.0|
Ulcer, Focal | | 2 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
10000PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 15 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 49 |
Angiectasis, Focal | | 7 2.1|
Congestion | | 2 2.0|
Hyperplasia, Focal | | 6 1.7|
Hypertrophy, Focal | | 4 1.3|
Necrosis, Focal | | 2 3.0|
Vacuolization Cytoplasmic, Focal | | 18 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | | 49 |
Hyperplasia | | 3 2.0|
Bilateral, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 44 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 11 2.4|
Pars Distalis, Hyperplasia, Focal | | 14 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
C-Cell, Hyperplasia, Focal | | 11 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 47 |
Hyperplasia | | 3 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 2 2.0|
Duct, Dilatation | | 9 2.0|
__________________________________________________________________________|____________|
Ovary | | 50 |
Cyst | | 4 2.5|
Bilateral, Cyst | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
10000PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | | 50 |
Cyst | | 6 1.7|
Cyst, Multiple | | 2 2.5|
__________________________________________________________________________|____________|
Vagina | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Atrophy | | 8 2.3|
__________________________________________________________________________|____________|
Lymph Node | | 14 |
Axillary, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hemorrhage | | 4 1.5|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Renal, Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 50 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 48 |
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 45 |
Hemorrhage | | 2 2.5|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Galactocele | | 17 2.4|
Hyperplasia, Focal | | 4 2.3|
Inflammation, Acute, Focal | | 1 3.0|
Inflammation, Chronic, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Hyperostosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
10000PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hydrocephalus | | 5 2.2|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 5 2.2|
Infiltration Cellular, Focal, | | |
Histiocyte | | 11 1.1|
Inflammation, Focal | | 8 1.6|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Arteriole, Mineralization, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 1 2.0|
Fungus | | 8 2.6|
Inflammation, Acute | | 3 2.7|
Inflammation, Chronic Active | | 9 2.6|
Inflammation, Subacute | | 4 2.3|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 46 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Mineralization, Focal | | 34 1.7|
Nephropathy | | 40 2.1|
Pigmentation, Focal | | 42 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 7| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 3| 2| 3| 3| 4| 3| 0| 7| 3|
| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 9| 9| 3| 3| 8| 4| 6| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X|
Congestion | 2 |
Degeneration, Cystic, Focal | 2 2 1 1 2 1 2 1 2 1 1 |
Developmental Malformation | X |
Eosinophilic Focus | X X X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 1 1 1 3 2 2 |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Inflammation, Chronic, Focal | 2 2 1 1 |
Mixed Cell Focus | X X |
Necrosis, Focal | 1 1 |
Pigmentation, Focal | |
Bile Duct, Cyst | 3 |
Bile Duct, Hyperplasia, Focal | 3 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 4|
Acinus, Atrophy, Focal | 2 1 3 3 3 2 2 2 1 3 2 2 3 |
Acinus, Vacuolization Cytoplasmic, | |
Focal | |
Artery, Inflammation, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | 2 |
Inflammation, Chronic, Focal | 2 |
Ulcer, Focal | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 7| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 3| 2| 3| 3| 4| 3| 0| 7| 3|
| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 9| 9| 3| 3| 8| 4| 6| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 2 2 2 1 2 3 2 3 2 2 2 2 2 2 2 2 2|
Mineralization, Focal | |
Atrium, Dilatation | 3 |
Atrium, Thrombosis | 2 |
Valve, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Focal | 1 1 |
Vacuolization Cytoplasmic, Focal | 2 1 2 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 2 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Bilateral, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M + + + + + + + + + + + M + + + M +|
Hyperplasia | |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 3 2 |
Pars Distalis, Hypertrophy, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 2 1 2 2 1 2 2 2 2 1 2 1 3 2 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Inflammation, Suppurative | 2 2 3 |
Duct, Dilatation | 2 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
Degeneration, Focal | |
Hyperplasia, Focal | 1 1 1 |
Inflammation, Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 7| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 3| 2| 3| 3| 4| 3| 0| 7| 3|
| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 9| 9| 3| 3| 8| 4| 6| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Focal, Suppurative | 1 2 2 |
Inflammation, Suppurative | |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 3 4 |
Cyst, Multiple | 3 |
Interstitial Cell, Hyperplasia, Focal| 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Bronchial, Hemorrhage | 3 |
Mediastinal, Hemorrhage | 2 3 1 2 2 |
Mediastinal, Hyperplasia, Plasma Cell| 3 3 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | 2 2 |
Hemorrhage | 1 2 |
Hyperplasia, Plasma Cell | 2 2 3 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Galactocele | 2 3 2 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 7| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 3| 2| 3| 3| 4| 3| 0| 7| 3|
| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 9| 9| 3| 3| 8| 4| 6| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Hydrocephalus | 2 2 3 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Necrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 3 |
Infiltration Cellular, Focal, | |
Histiocyte | 1 1 1|
Inflammation, Focal | 1 1 1 1 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | 2 2 |
Fungus | 2 3 2 3 2 2 2 |
Hemorrhage | 2 |
Inflammation, Acute | 2 2 2 1 |
Inflammation, Chronic Active | 3 3 3 3 2 2 2 |
Inflammation, Subacute | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Phthisis Bulbi | 3 |
Cornea, Inflammation | |
Lens, Cataract | 3 2 |
Lens, Inflammation, Focal, Subacute | 2 |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 2 3 3 2 2 2 3 2 3 2 2 2 2 2 1 2 2 3 2 3 2 4 2|
Pigmentation, Focal | 1 2 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 1| 7| 1| 3| 7| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 7| 1| 8| 3| 3| 3|
| 4| 2| 4| 4| 5| 0| 4| 4| 9| 4| 4| 3| 4| 4| 4| 4| 7| 4| 4| 2| 8| 2| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X |
Congestion | 2 2 |
Degeneration, Cystic, Focal | 2 1 1 2 |
Developmental Malformation | X |
Eosinophilic Focus | X X X X X X |
Fatty Change, Diffuse | 3 |
Fatty Change, Focal | 1 1 1 1 |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Chronic, Focal | 1 1 |
Mixed Cell Focus | X X|
Necrosis, Focal | |
Pigmentation, Focal | 2 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia, Focal | 3 3 2 2 2 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis, Focal | 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 3 3 1 2 3 2 2 1 2 2 2 2 2 3 3|
Acinus, Vacuolization Cytoplasmic, | |
Focal | 1 |
Artery, Inflammation, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic, Focal | |
Ulcer, Focal | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 1| 7| 1| 3| 7| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 7| 1| 8| 3| 3| 3|
| 4| 2| 4| 4| 5| 0| 4| 4| 9| 4| 4| 3| 4| 4| 4| 4| 7| 4| 4| 2| 8| 2| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 3 3 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2|
Mineralization, Focal | 2 |
Atrium, Dilatation | 3 |
Atrium, Thrombosis | X 3 4 3 X|
Valve, Degeneration | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia, Focal | 2 2 1 3 |
Vacuolization Cytoplasmic, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 3 1 2 1 2 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Bilateral, Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 3 1 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + M + + + + + + + + + + M +|
Hyperplasia | 2 |
Bilateral, Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 4 |
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Hyperplasia, Focal | 3 2 2 3 1 2 |
Pars Distalis, Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 1 2 2 1 3 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Suppurative | 3 2 |
Duct, Dilatation | 2 3 3 3 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 3 2 2 3|
Degeneration, Focal | 2 |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 1| 7| 1| 3| 7| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 7| 1| 8| 3| 3| 3|
| 4| 2| 4| 4| 5| 0| 4| 4| 9| 4| 4| 3| 4| 4| 4| 4| 7| 4| 4| 2| 8| 2| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Focal, Suppurative | |
Inflammation, Suppurative | 2 3 2 |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst, Multiple | |
Interstitial Cell, Hyperplasia, Focal| 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Bronchial, Hemorrhage | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Plasma Cell| |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cyst | 2 |
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | 2 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 3 2 |
Hematopoietic Cell Proliferation | 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 4 4 |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 1| 7| 1| 3| 7| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 7| 1| 8| 3| 3| 3|
| 4| 2| 4| 4| 5| 0| 4| 4| 9| 4| 4| 3| 4| 4| 4| 4| 7| 4| 4| 2| 8| 2| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hydrocephalus | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 4 |
Infiltration Cellular, Focal, | |
Histiocyte | 2 1 2 |
Inflammation, Focal | 2 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Foreign Body | 2 2 3 |
Fungus | |
Hemorrhage | 2 |
Inflammation, Acute | 2 2 3 |
Inflammation, Chronic Active | 2 3 |
Inflammation, Subacute | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | |
Cornea, Inflammation | 2 |
Lens, Cataract | 3 |
Lens, Inflammation, Focal, Subacute | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + M + + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 3 3 2 2 2 2 4 3 3 2 1 2 4 2 2 2 3 2 3 3 2 3|
Pigmentation, Focal | 2 1 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 46 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 30 |
Clear Cell Focus | | 13 |
Congestion | | 3 2.0|
Degeneration, Cystic, Focal | | 15 1.5|
Developmental Malformation | | 2 |
Eosinophilic Focus | | 9 |
Fatty Change, Diffuse | | 1 3.0|
Fatty Change, Focal | | 11 1.4|
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Chronic, Focal | | 6 1.3|
Mixed Cell Focus | | 4 |
Necrosis, Focal | | 2 1.0|
Pigmentation, Focal | | 1 2.0|
Bile Duct, Cyst | | 1 3.0|
Bile Duct, Hyperplasia, Focal | | 6 2.5|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Necrosis, Focal | | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Atrophy, Diffuse | | 1 4.0|
Acinus, Atrophy, Focal | | 28 2.2|
Acinus, Vacuolization Cytoplasmic, | | |
Focal | | 1 1.0|
Artery, Inflammation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Atrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia, Focal, Squamous | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer, Focal | | 4 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 37 2.1|
Mineralization, Focal | | 1 2.0|
Atrium, Dilatation | | 2 3.0|
Atrium, Thrombosis | | 6 3.0|
Valve, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 49 |
Hemorrhage | | 1 4.0|
Hyperplasia, Focal | | 6 1.7|
Vacuolization Cytoplasmic, Focal | | 8 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | | 49 |
Hyperplasia | | 16 1.8|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 1.0|
Bilateral, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia, Focal | | 5 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | | 43 |
Hyperplasia | | 1 2.0|
Bilateral, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Angiectasis, Focal | | 1 4.0|
Pars Distalis, Cyst | | 3 2.0|
Pars Distalis, Hyperplasia, Focal | | 12 2.2|
Pars Distalis, Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia, Focal | | 7 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Degeneration, Focal | | 31 1.9|
__________________________________________________________________________|____________|
Preputial Gland | | 50 |
Hyperplasia | | 3 2.3|
Inflammation, Suppurative | | 5 2.4|
Duct, Dilatation | | 10 2.7|
__________________________________________________________________________|____________|
Prostate | | 50 |
Atrophy | | 10 2.3|
Degeneration, Focal | | 1 2.0|
Hyperplasia, Focal | | 3 1.0|
Inflammation, Chronic, Focal | | 1 3.0|
Inflammation, Focal, Suppurative | | 3 1.7|
Inflammation, Suppurative | | 3 2.3|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
__________________________________________________________________________|____________|
Testes | | 50 |
Atrophy | | 4 3.5|
Cyst, Multiple | | 1 3.0|
Interstitial Cell, Hyperplasia, Focal| | 4 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 15 |
Bronchial, Hemorrhage | | 1 3.0|
Mediastinal, Hemorrhage | | 5 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 2 3.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Cyst | | 3 2.0|
Hemorrhage | | 3 1.7|
Hyperplasia, Plasma Cell | | 9 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 49 |
Hemorrhage | | 2 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Congestion | | 1 2.0|
Fibrosis, Focal | | 2 2.5|
Hematopoietic Cell Proliferation | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 48 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 48 |
Galactocele | | 6 2.8|
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hemorrhage, Focal | | 1 2.0|
Hydrocephalus | | 4 2.3|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Necrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 6 2.7|
Infiltration Cellular, Focal, | | |
Histiocyte | | 6 1.3|
Inflammation, Focal | | 7 1.3|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Congestion | | 1 3.0|
Foreign Body | | 5 2.2|
Fungus | | 7 2.3|
Hemorrhage | | 2 2.0|
Inflammation, Acute | | 7 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 9 2.6|
Inflammation, Subacute | | 5 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Phthisis Bulbi | | 1 3.0|
Cornea, Inflammation | | 1 2.0|
Lens, Cataract | | 3 2.7|
Lens, Inflammation, Focal, Subacute | | 1 2.0|
Retina, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 48 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Nephropathy | | 48 2.4|
Pigmentation, Focal | | 12 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 0| 3| 3| 3| 4| 3| 3| 3| 2| 3| 3| 1| 3| 5| 8| 3| 3| 3| 7| 5| 3| 3| 3| 3|
| 1| 1| 7| 0| 0| 1| 0| 0| 7| 1| 0| 0| 3| 0| 1| 5| 0| 0| 0| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X|
Congestion | 2 |
Degeneration, Cystic, Focal | 1 2 1 2 2 1 1 2|
Developmental Malformation | |
Eosinophilic Focus | X X X X X X X X X X|
Fatty Change, Diffuse | 3 |
Fatty Change, Focal | 1 3 |
Inflammation, Chronic, Focal | 1 |
Mixed Cell Focus | X |
Necrosis, Focal | 2 |
Bile Duct, Hyperplasia, Focal | 2 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis, Focal | 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Acinus, Atrophy, Diffuse | 4 |
Acinus, Atrophy, Focal | 2 1 2 2 2 2 1 2 2 2 2 3 2 2 1|
__________________________________________________________________________|
Pharynx | + |
Palate, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | |
Hyperplasia, Basal Cell, Focal | 1 |
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic, Focal | |
Inflammation, Chronic Active, Focal | |
Ulcer, Focal | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 |
Inflammation, Acute, Focal | |
Ulcer, Focal | 2 |
__________________________________________________________________________|
Tooth | + |
Gingiva, Inflammation, Chronic Active| 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 0| 3| 3| 3| 4| 3| 3| 3| 2| 3| 3| 1| 3| 5| 8| 3| 3| 3| 7| 5| 3| 3| 3| 3|
| 1| 1| 7| 0| 0| 1| 0| 0| 7| 1| 0| 0| 3| 0| 1| 5| 0| 0| 0| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 2 1 1 1 2 2 2 2 1 1 1 2 1|
Atrium, Dilatation | 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Congestion | 1 |
Cyst | |
Degeneration, Cystic, Focal | 2 |
Hyperplasia, Focal | 2|
Vacuolization Cytoplasmic, Focal | 2 2 3 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 3 2 |
Bilateral, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Pigmentation, Focal | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 3 1 1 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 3 2 2 1 3|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Suppurative | |
Duct, Dilatation | 2 3 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Atrophy | 2 2 2 |
Degeneration, Focal | 1 |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 0| 3| 3| 3| 4| 3| 3| 3| 2| 3| 3| 1| 3| 5| 8| 3| 3| 3| 7| 5| 3| 3| 3| 3|
| 1| 1| 7| 0| 0| 1| 0| 0| 7| 1| 0| 0| 3| 0| 1| 5| 0| 0| 0| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Focal, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3|
Mineralization, Focal | |
Bilateral, Atrophy | |
Interstitial Cell, Hyperplasia, Focal| 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Bronchial, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Hemorrhage | |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | |
Hyperplasia, Plasma Cell | 3 3 3 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hemorrhage | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + M + + + + M + + M + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Galactocele | 3 2 2 |
Hyperplasia, Focal | 3 1 |
Inflammation, Acute, Focal | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 0| 3| 3| 3| 4| 3| 3| 3| 2| 3| 3| 1| 3| 5| 8| 3| 3| 3| 7| 5| 3| 3| 3| 3|
| 1| 1| 7| 0| 0| 1| 0| 0| 7| 1| 0| 0| 3| 0| 1| 5| 0| 0| 0| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hydrocephalus | |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Focal, | |
Histiocyte | 1 1 1|
Inflammation, Focal | 1 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | 2 3 3 2 |
Hemorrhage | |
Inflammation, Acute | 2 2 |
Inflammation, Chronic Active | 2 2 2 3 3 |
Inflammation, Subacute | 2 |
Olfactory Epithelium, Necrosis, Focal| 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Inflammation, Chronic | 3 |
Phthisis Bulbi | |
Lens, Cataract | |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + + + M + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 2 2 3 4 2 3 2 1 3 2 2 2 1 1 2 2 2 2 2 2 2 2 3 3|
Pigmentation, Focal | 2 3 2 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 6|
DAY ON TEST | 1| 1| 1| 2| 1| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 6| 1| 3| 4| 3| 7|
| 5| 7| 4| 6| 4| 3| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 0| 0| 8| 3| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X |
Congestion | 3 2 2 |
Degeneration, Cystic, Focal | 1 2 1 2 2|
Developmental Malformation | X |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 4 3 2 3 |
Fatty Change, Focal | 1 1 3 1 1 1 1 1 2 |
Inflammation, Chronic, Focal | 1 |
Mixed Cell Focus | |
Necrosis, Focal | 1 1 |
Bile Duct, Hyperplasia, Focal | 3|
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 2 2 2 1 1 2 2 2 1 1 1|
__________________________________________________________________________|
Pharynx | |
Palate, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 3 |
Hyperplasia, Basal Cell, Focal | 1 |
Hyperplasia, Focal, Squamous | 3 |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic Active, Focal | 3 2 |
Ulcer, Focal | 3 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 |
Inflammation, Acute, Focal | 2 |
Ulcer, Focal | 2 2|
__________________________________________________________________________|
Tooth | |
Gingiva, Inflammation, Chronic Active| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 6|
DAY ON TEST | 1| 1| 1| 2| 1| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 6| 1| 3| 4| 3| 7|
| 5| 7| 4| 6| 4| 3| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 0| 0| 8| 3| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 1 1 2 2 1 2 2 2 2 |
Atrium, Dilatation | 3 3 |
Atrium, Thrombosis | X 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Congestion | |
Cyst | 3 |
Degeneration, Cystic, Focal | 1 |
Hyperplasia, Focal | 2 1 1 2 1 |
Vacuolization Cytoplasmic, Focal | 2 1 2 2 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 1 2 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Pigmentation, Focal | 2 |
Pars Distalis, Cyst | 2 3 |
Pars Distalis, Hyperplasia, Focal | 2 1 1 3 1 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 3 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 3 2 2 2 2 2 1 2 2 3 2 2 3 1 3 3 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 4 3 2 |
Duct, Dilatation | 3 3 2 2 2 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Atrophy | 2 2 2 2 |
Degeneration, Focal | |
Inflammation, Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 6|
DAY ON TEST | 1| 1| 1| 2| 1| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 6| 1| 3| 4| 3| 7|
| 5| 7| 4| 6| 4| 3| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 0| 0| 8| 3| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Focal, Suppurative | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Mineralization, Focal | 2 |
Bilateral, Atrophy | 2 2 |
Interstitial Cell, Hyperplasia, Focal| 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Bronchial, Infiltration Cellular, | |
Histiocyte | 3 |
Mediastinal, Hemorrhage | 3 3 |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | 3 2 |
Hyperplasia, Plasma Cell | 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M + M M M M M + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 3 2 2 |
Hyperplasia, Focal | |
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 6|
DAY ON TEST | 1| 1| 1| 2| 1| 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 6| 1| 3| 4| 3| 7|
| 5| 7| 4| 6| 4| 3| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 0| 0| 8| 3| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hydrocephalus | 2 2 3 2 |
Necrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1 1 |
Infiltration Cellular, Focal, | |
Histiocyte | 1 |
Inflammation, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Fungus | 2 3 |
Hemorrhage | 3 |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 3 4 3 3 |
Inflammation, Subacute | |
Olfactory Epithelium, Necrosis, Focal| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Inflammation, Chronic | |
Phthisis Bulbi | 3 |
Lens, Cataract | 4 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 2 2 3 2 4 3 1 2 3 2 2 2 2 3 2 2 3 3 4 2 2 3 4 2|
Pigmentation, Focal | 2 3 3 3 3 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 49 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Focal | | 2 2.0|
Basophilic Focus | | 26 |
Clear Cell Focus | | 13 |
Congestion | | 4 2.3|
Degeneration, Cystic, Focal | | 13 1.5|
Developmental Malformation | | 1 |
Eosinophilic Focus | | 11 |
Fatty Change, Diffuse | | 5 3.0|
Fatty Change, Focal | | 11 1.5|
Inflammation, Chronic, Focal | | 2 1.0|
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 3 1.3|
Bile Duct, Hyperplasia, Focal | | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Necrosis, Focal | | 5 2.8|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Accessory Spleen | | 1 |
Acinus, Atrophy, Diffuse | | 1 4.0|
Acinus, Atrophy, Focal | | 26 1.7|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Acanthosis, Focal | | 1 3.0|
Hyperplasia, Basal Cell, Focal | | 2 1.0|
Hyperplasia, Focal, Squamous | | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Chronic Active, Focal | | 2 2.5|
Ulcer, Focal | | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Erosion, Focal | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Acute, Focal | | 1 2.0|
Ulcer, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Gingiva, Inflammation, Chronic Active| | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 31 1.7|
Atrium, Dilatation | | 3 3.0|
Atrium, Thrombosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 50 |
Angiectasis, Focal | | 1 2.0|
Congestion | | 1 1.0|
Cyst | | 1 3.0|
Degeneration, Cystic, Focal | | 2 1.5|
Hyperplasia, Focal | | 6 1.5|
Vacuolization Cytoplasmic, Focal | | 12 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | | 50 |
Hyperplasia | | 12 1.8|
Bilateral, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia, Focal | | 4 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Angiectasis, Focal | | 1 2.0|
Pigmentation, Focal | | 1 2.0|
Pars Distalis, Cyst | | 2 2.5|
Pars Distalis, Hyperplasia, Focal | | 16 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia, Focal | | 6 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Degeneration, Focal | | 38 2.1|
__________________________________________________________________________|____________|
Preputial Gland | | 50 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 3 3.0|
Duct, Dilatation | | 17 2.4|
__________________________________________________________________________|____________|
Prostate | | 50 |
Abscess | | 1 3.0|
Atrophy | | 7 2.0|
Degeneration, Focal | | 1 1.0|
Inflammation, Chronic, Focal | | 1 3.0|
Inflammation, Focal, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Atrophy | | 3 3.0|
Mineralization, Focal | | 1 2.0|
Bilateral, Atrophy | | 2 2.0|
Interstitial Cell, Hyperplasia, Focal| | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 16 |
Bronchial, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Mediastinal, Hemorrhage | | 2 3.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Cyst | | 2 2.0|
Hemorrhage | | 2 2.5|
Hyperplasia, Plasma Cell | | 10 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 50 |
Cyst | | 1 3.0|
Hemorrhage | | 2 3.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Depletion Cellular | | 1 3.0|
Fibrosis, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
Galactocele | | 7 2.3|
Hyperplasia, Focal | | 2 2.0|
Inflammation, Acute, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hydrocephalus | | 4 2.3|
Necrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 3 1.0|
Infiltration Cellular, Focal, | | |
Histiocyte | | 4 1.0|
Inflammation, Focal | | 2 1.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 2 2.5|
Fungus | | 6 2.5|
Hemorrhage | | 1 3.0|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic Active | | 10 2.8|
Inflammation, Subacute | | 1 2.0|
Olfactory Epithelium, Necrosis, Focal| | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Inflammation, Chronic | | 1 3.0|
Phthisis Bulbi | | 1 3.0|
Lens, Cataract | | 1 4.0|
Retina, Atrophy | | 2 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 48 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Nephropathy | | 50 2.4|
Pigmentation, Focal | | 11 2.6|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 8| 7| 2| 7| 3| 2| 2| 2| 2| 2| 2| 3| 9| 2| 2| 2| 8| 3| 3| 3| 3| 3|
| 9| 6| 9| 1| 1| 9| 7| 7| 9| 9| 9| 9| 9| 9| 2| 2| 9| 9| 9| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 1 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X|
Congestion | 2 |
Degeneration, Cystic, Focal | 1 1 2 1 1 2 |
Eosinophilic Focus | X X X X X X X X X X|
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 2 1 1 1 1 1 |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | 1 1 |
Necrosis, Focal | |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia, Focal | 3 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 2 |
Acinus, Atrophy, Diffuse | 4 |
Acinus, Atrophy, Focal | 2 2 2 2 2 2 3 3 1 1 1 1 2 2 3 |
Acinus, Hyperplasia, Focal | 2 |
Artery, Inflammation, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell, Focal | 1 1 1 1 1|
Hyperplasia, Focal, Squamous | 2 1 2 1 |
Inflammation, Chronic Active, Focal | 2 |
Ulcer, Focal | 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Basal Cell, Focal | 4 |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 8| 7| 2| 7| 3| 2| 2| 2| 2| 2| 2| 3| 9| 2| 2| 2| 8| 3| 3| 3| 3| 3|
| 9| 6| 9| 1| 1| 9| 7| 7| 9| 9| 9| 9| 9| 9| 2| 2| 9| 9| 9| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 3 2 1 2 2 2 2 2 2 2 2 2 2 2 2 3|
Mineralization, Focal | |
Atrium, Dilatation | 3 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 1 |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 2 1 2 2 2 1 3 3|
Bilateral, Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + M + + + + + + M + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 3 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 3 1 2 2 |
Follicular Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 2 1 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | |
Duct, Dilatation | 2 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 2 2 3 |
Hyperplasia, Focal | 2 1 |
Inflammation, Chronic, Focal | |
Inflammation, Focal, Granulomatous | 1 2 |
Inflammation, Focal, Suppurative | 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 8| 7| 2| 7| 3| 2| 2| 2| 2| 2| 2| 3| 9| 2| 2| 2| 8| 3| 3| 3| 3| 3|
| 9| 6| 9| 1| 1| 9| 7| 7| 9| 9| 9| 9| 9| 9| 2| 2| 9| 9| 9| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 2 3 |
Cyst | 2 3 |
Artery, Inflammation, Focal | 2 |
Interstitial Cell, Hyperplasia, Focal| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Lumbar, Hemorrhage | 1 |
Lumbar, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinal, Cyst | 2 |
Mediastinal, Hemorrhage | 2 2 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 3 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
Hemorrhage | 1 |
Hyperplasia, Plasma Cell | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis, Focal | 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 8| 7| 2| 7| 3| 2| 2| 2| 2| 2| 2| 3| 9| 2| 2| 2| 8| 3| 3| 3| 3| 3|
| 9| 6| 9| 1| 1| 9| 7| 7| 9| 9| 9| 9| 9| 9| 2| 2| 9| 9| 9| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Mineralization, Focal | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Focal, | |
Histiocyte | 3 1 |
Inflammation, Focal | 2 1 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + M + + + + + + + + +|
Congestion | 3 |
Foreign Body | 3 2 |
Fungus | 3 3 3 2 3 2 3 |
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 3 3 3 2 3 2 3 |
Inflammation, Subacute | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cornea, Degeneration, Focal | 3 |
Lens, Cataract | 3 |
__________________________________________________________________________|
Zymbal's Gland | + M + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | 4 |
Nephropathy | 4 3 3 2 2 3 2 2 3 3 2 3 3 4 1 2 4 4 3 1 3 1 3 4 3|
Pigmentation, Focal | 2 1 2 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 6| 6|
DAY ON TEST | 7| 0| 2| 3| 3| 9| 3| 3| 3| 3| 3| 1| 0| 3| 3| 3| 7| 5| 2| 3| 3| 3| 9| 4| 7|
| 0| 0| 1| 0| 0| 2| 0| 0| 0| 0| 0| 4| 9| 0| 0| 0| 4| 6| 5| 0| 0| 0| 4| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3000 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X |
Congestion | 2 3 4|
Degeneration, Cystic, Focal | 2 2 1 2 2 1 2 2 2 3 3 1 |
Eosinophilic Focus | X X X X X |
Fatty Change, Diffuse | 3 |
Fatty Change, Focal | 3 1 1 2 1 |
Hyperplasia, Focal | 3 |
Inflammation, Chronic, Focal | 1 1 1 |
Necrosis, Focal | 2 |
Bile Duct, Cyst | 1 1 |
Bile Duct, Hyperplasia, Focal | 3 3 3 3 2 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis, Focal | 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 2 2 1 1 3 2 2 1 1 1 2 1 2 2 |
Acinus, Hyperplasia, Focal | |
Artery, Inflammation, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell, Focal | 1 1 1 1 1 |
Hyperplasia, Focal, Squamous | 2 3 |
Inflammation, Chronic Active, Focal | 2 |
Ulcer, Focal | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia, Basal Cell, Focal | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 6| 6|
DAY ON TEST | 7| 0| 2| 3| 3| 9| 3| 3| 3| 3| 3| 1| 0| 3| 3| 3| 7| 5| 2| 3| 3| 3| 9| 4| 7|
| 0| 0| 1| 0| 0| 2| 0| 0| 0| 0| 0| 4| 9| 0| 0| 0| 4| 6| 5| 0| 0| 0| 4| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3000 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 1 2 1 1 2 2 2 2 3 2 2 2 2|
Mineralization, Focal | 2 |
Atrium, Dilatation | 3 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 |
Vacuolization Cytoplasmic, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 2 2 1 2 2|
Bilateral, Hyperplasia | 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia, Focal | 3 1 3 2 2 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 2 2 2 1 |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 3 1 2 2 2 2 1 2 1 2 1 1 3 2 2 2 3 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | 3 2 |
Duct, Dilatation | 2 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 1 2 2 |
Hyperplasia, Focal | 2 |
Inflammation, Chronic, Focal | 2 2 |
Inflammation, Focal, Granulomatous | 2 |
Inflammation, Focal, Suppurative | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 6| 6|
DAY ON TEST | 7| 0| 2| 3| 3| 9| 3| 3| 3| 3| 3| 1| 0| 3| 3| 3| 7| 5| 2| 3| 3| 3| 9| 4| 7|
| 0| 0| 1| 0| 0| 2| 0| 0| 0| 0| 0| 4| 9| 0| 0| 0| 4| 6| 5| 0| 0| 0| 4| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3000 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 |
Cyst | |
Artery, Inflammation, Focal | |
Interstitial Cell, Hyperplasia, Focal| 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Lumbar, Hemorrhage | |
Lumbar, Infiltration Cellular, | |
Histiocyte | 3 |
Mediastinal, Cyst | |
Mediastinal, Hemorrhage | 1 3 3 |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Hemorrhage | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Renal, Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Cyst | 2 3 2 |
Hemorrhage | 1 1 |
Hyperplasia, Plasma Cell | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 1 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 6| 6|
DAY ON TEST | 7| 0| 2| 3| 3| 9| 3| 3| 3| 3| 3| 1| 0| 3| 3| 3| 7| 5| 2| 3| 3| 3| 9| 4| 7|
| 0| 0| 1| 0| 0| 2| 0| 0| 0| 0| 0| 4| 9| 0| 0| 0| 4| 6| 5| 0| 0| 0| 4| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3000 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
Mineralization, Focal | 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1 |
Infiltration Cellular, Focal, | |
Histiocyte | 1 1 1 1 |
Inflammation, Focal | 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | 2 |
Fungus | 3 3 3 3 3 3 3 3 3 |
Hemorrhage | 3 |
Inflammation, Acute | 3 |
Inflammation, Chronic Active | 3 3 4 3 3 2 3 4 3 3 3 2 |
Inflammation, Subacute | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Degeneration, Focal | |
Lens, Cataract | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
Hydronephrosis | |
Nephropathy | 3 3 2 3 4 2 4 3 3 3 4 3 3 3 4 3 3 1 4 2 3 3 2 3 2|
Pigmentation, Focal | 3 3 3 2 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
3000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
Hyperplasia, Focal, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 48 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Focal | | 7 1.9|
Basophilic Focus | | 34 |
Clear Cell Focus | | 19 |
Congestion | | 4 2.8|
Degeneration, Cystic, Focal | | 18 1.7|
Eosinophilic Focus | | 15 |
Fatty Change, Diffuse | | 1 3.0|
Fatty Change, Focal | | 12 1.3|
Hyperplasia, Focal | | 1 3.0|
Inflammation, Chronic, Focal | | 5 1.0|
Necrosis, Focal | | 1 2.0|
Bile Duct, Cyst | | 2 1.0|
Bile Duct, Hyperplasia, Focal | | 9 2.8|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Fat, Necrosis, Focal | | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Inflammation, Acute, Focal | | 1 2.0|
Acinus, Atrophy, Diffuse | | 1 4.0|
Acinus, Atrophy, Focal | | 29 1.8|
Acinus, Hyperplasia, Focal | | 1 2.0|
Artery, Inflammation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia, Basal Cell, Focal | | 10 1.0|
Hyperplasia, Focal, Squamous | | 6 1.8|
Inflammation, Chronic Active, Focal | | 2 2.0|
Ulcer, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Cyst | | 1 2.0|
Hyperplasia, Basal Cell, Focal | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
3000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation, | | |
Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 38 2.0|
Mineralization, Focal | | 1 2.0|
Atrium, Dilatation | | 3 3.0|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 50 |
Hyperplasia, Focal | | 6 1.7|
Vacuolization Cytoplasmic, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | | 50 |
Cyst | | 1 2.0|
Hyperplasia | | 14 1.9|
Bilateral, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia, Focal | | 7 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | | 46 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
Pars Distalis, Cyst | | 3 3.0|
Pars Distalis, Hyperplasia, Focal | | 11 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia, Focal | | 10 1.9|
Follicular Cell, Hyperplasia, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
Degeneration, Focal | | 37 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 50 |
Hyperplasia | | 2 2.0|
Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
3000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Dilatation | | 9 2.1|
__________________________________________________________________________|____________|
Prostate | | 50 |
Atrophy | | 11 2.1|
Hyperplasia, Focal | | 3 1.7|
Inflammation, Chronic, Focal | | 2 2.0|
Inflammation, Focal, Granulomatous | | 3 1.7|
Inflammation, Focal, Suppurative | | 4 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Atrophy | | 4 2.8|
Cyst | | 2 2.5|
Artery, Inflammation, Focal | | 1 2.0|
Interstitial Cell, Hyperplasia, Focal| | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Atrophy | | 1 2.0|
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | | 23 |
Lumbar, Hemorrhage | | 1 1.0|
Lumbar, Infiltration Cellular, | | |
Histiocyte | | 2 2.5|
Mediastinal, Cyst | | 1 2.0|
Mediastinal, Hemorrhage | | 5 2.2|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Pancreatic, Hemorrhage | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Renal, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Cyst | | 6 2.2|
Hemorrhage | | 3 1.0|
Hyperplasia, Plasma Cell | | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 50 |
Edema | | 1 3.0|
Hemorrhage | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
3000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | | 50 |
Congestion | | 1 2.0|
Fibrosis, Focal | | 4 2.0|
__________________________________________________________________________|____________|
Thymus | | 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Galactocele | | 1 3.0|
Hyperplasia, Focal | | 3 1.7|
__________________________________________________________________________|____________|
Skin | | 50 |
Acanthosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Fibrous Osteodystrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hydrocephalus | | 1 2.0|
Mineralization, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 3 1.3|
Infiltration Cellular, Focal, | | |
Histiocyte | | 6 1.3|
Inflammation, Focal | | 7 1.4|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 3 2.0|
__________________________________________________________________________|____________|
Nose | | 49 |
Congestion | | 1 3.0|
Foreign Body | | 3 2.3|
Fungus | | 16 2.9|
Hemorrhage | | 1 3.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic Active | | 20 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
3000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Subacute | | 3 1.7|
__________________________________________________________________________|____________|
Trachea | | 50 |
Inflammation, Chronic Active, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Cornea, Degeneration, Focal | | 1 3.0|
Lens, Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 48 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Cyst | | 2 2.5|
Hydronephrosis | | 1 4.0|
Nephropathy | | 50 2.8|
Pigmentation, Focal | | 15 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 5| 3| 7| 7| 6| 7| 6| 4| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 0| 2| 6| 0| 2| 2| 4| 2| 9| 6| 2| 2| 2| 4| 2| 8| 8| 8| 2| 2| 0| 2| 2|
| 0| 9| 6| 9| 6| 5| 9| 9| 6| 9| 9| 0| 9| 2| 9| 6| 9| 0| 4| 3| 9| 9| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2|
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X|
Congestion | 2 |
Degeneration, Cystic, Focal | 1 2 2 1 2 2 2 3 2 1 2 2|
Eosinophilic Focus | X X X X X X X X X X X X|
Fatty Change, Focal | 1 1 2 2 1 1 2 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic, Focal | 1 2 |
Mixed Cell Focus | X X X X X |
Necrosis, Focal | 2 2 3 |
Pigmentation, Focal | |
Bile Duct, Cyst | |
Bile Duct, Fibrosis | 4 |
Bile Duct, Hyperplasia, Focal | 3 3 |
Centrilobular, Atrophy, Focal | 2 |
Vein, Dilatation | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 2 1 1 1 1 1 2 1 2 2 2 2 2 3 1 1 |
Acinus, Cytoplasmic Alteration, Focal| 2 |
__________________________________________________________________________|
Pharynx | + + + + + |
Palate, Hyperplasia, Focal, Squamous | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 |
Hyperplasia, Basal Cell, Focal | 2 1 1 2 1 1 2 1 2 2 1 2|
Hyperplasia, Focal, Plasma Cell | 2 |
Hyperplasia, Focal, Squamous | 1 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 5| 3| 7| 7| 6| 7| 6| 4| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 0| 2| 6| 0| 2| 2| 4| 2| 9| 6| 2| 2| 2| 4| 2| 8| 8| 8| 2| 2| 0| 2| 2|
| 0| 9| 6| 9| 6| 5| 9| 9| 6| 9| 9| 0| 9| 2| 9| 6| 9| 0| 4| 3| 9| 9| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 2 2 2 1 2 2 2 2 1 3 3 2 2 1|
Mineralization, Focal | |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst, Multiple | |
Hemorrhage | |
Hyperplasia, Focal | 2|
Vacuolization Cytoplasmic, Focal | 1 2 3 3 2 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 4 3 3 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + M + + + + M + + + + +|
Bilateral, Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 3 2 1 1 2 2 1 2 2 2 1 |
Pars Nervosa, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 |
Follicle, Dilatation, Focal | 3 2 |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 3 2 2 1 2 2 1 3 2 2 2 3 2 1 2 1 3 2 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
Duct, Dilatation | 1 2 3 3 3 2 |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +|
Abscess | |
Atrophy | 2 2 2 2 3 2 2 2|
Inflammation, Chronic, Focal | 2 3 2 |
Inflammation, Focal, Granulomatous | 2 |
Inflammation, Focal, Suppurative | 3 3 |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 5| 3| 7| 7| 6| 7| 6| 4| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 0| 2| 6| 0| 2| 2| 4| 2| 9| 6| 2| 2| 2| 4| 2| 8| 8| 8| 2| 2| 0| 2| 2|
| 0| 9| 6| 9| 6| 5| 9| 9| 6| 9| 9| 0| 9| 2| 9| 6| 9| 0| 4| 3| 9| 9| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + M + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 4 |
Interstitial Cell, Hyperplasia, Focal| 2 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Axillary, Hyperplasia, Plasma Cell | 2 |
Iliac, Cyst | X |
Iliac, Infiltration Cellular, | |
Histiocyte | 2 |
Inguinal, Cyst | X |
Lumbar, Hemorrhage | 2 |
Lumbar, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
Pancreatic, Hemorrhage | |
Renal, Hemorrhage | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hemorrhage | |
Hyperplasia, Plasma Cell | 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 2 |
Hematopoietic Cell Proliferation | 2 3 |
Capsule, Cyst | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M M + + M + + + + +|
Galactocele | 3 |
Hyperplasia, Focal | 3 2 |
Inflammation, Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 5| 3| 7| 7| 6| 7| 6| 4| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 0| 2| 6| 0| 2| 2| 4| 2| 9| 6| 2| 2| 2| 4| 2| 8| 8| 8| 2| 2| 0| 2| 2|
| 0| 9| 6| 9| 6| 5| 9| 9| 6| 9| 9| 0| 9| 2| 9| 6| 9| 0| 4| 3| 9| 9| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Pigmentation, Focal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis, Focal | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage, Focal | 2 |
Infiltration Cellular, Focal, | |
Histiocyte | 2 1 1 1 |
Inflammation, Focal | 1 1 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | 3 2 3 2 |
Hemorrhage | 2 |
Inflammation, Chronic Active | 3 2 3 2 2 2 3 |
Inflammation, Subacute | 2 |
Glands, Dilatation, Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 5| 3| 7| 7| 6| 7| 6| 4| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 0| 2| 6| 0| 2| 2| 4| 2| 9| 6| 2| 2| 2| 4| 2| 8| 8| 8| 2| 2| 0| 2| 2|
| 0| 9| 6| 9| 6| 5| 9| 9| 6| 9| 9| 0| 9| 2| 9| 6| 9| 0| 4| 3| 9| 9| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infarct | |
Mineralization, Focal | 1 |
Nephropathy | 3 3 3 2 3 2 3 3 2 2 4 2 3 2 3 2 4 2 2 3 3 3 3|
Pigmentation, Focal | 2 1 3 2 2 3 2 2 1 1 3 |
Pelvis, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 4| 7| 5| 7| 7|
DAY ON TEST | 2| 0| 2| 3| 0| 2| 1| 2| 2| 2| 2| 1| 3| 8| 0| 2| 2| 6| 9| 2| 5| 2| 0| 2| 2|
| 9| 2| 9| 2| 1| 9| 0| 9| 9| 9| 9| 4| 1| 0| 6| 9| 9| 8| 2| 9| 0| 2| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + A A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X X|
Clear Cell Focus | X X X X X X X|
Congestion | |
Degeneration, Cystic, Focal | 1 1 1 2 2 2 1 2 1 1 2 2 1|
Eosinophilic Focus | X X X X X X X X |
Fatty Change, Focal | 1 2 1 3 2 1 1 2|
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic, Focal | |
Mixed Cell Focus | X X |
Necrosis, Focal | |
Pigmentation, Focal | 2 |
Bile Duct, Cyst | 1 |
Bile Duct, Fibrosis | |
Bile Duct, Hyperplasia, Focal | |
Centrilobular, Atrophy, Focal | |
Vein, Dilatation | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 4 |
Acinus, Atrophy, Focal | 2 2 2 2 2 2 2 1 2 1 |
Acinus, Cytoplasmic Alteration, Focal| |
__________________________________________________________________________|
Pharynx | + + + + |
Palate, Hyperplasia, Focal, Squamous | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | |
Hyperplasia, Basal Cell, Focal | 1 1 1 2 2 1 1 |
Hyperplasia, Focal, Plasma Cell | |
Hyperplasia, Focal, Squamous | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 4| 7| 5| 7| 7|
DAY ON TEST | 2| 0| 2| 3| 0| 2| 1| 2| 2| 2| 2| 1| 3| 8| 0| 2| 2| 6| 9| 2| 5| 2| 0| 2| 2|
| 9| 2| 9| 2| 1| 9| 0| 9| 9| 9| 9| 4| 1| 0| 6| 9| 9| 8| 2| 9| 0| 2| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 3 2 2 2 3 2 1 2 2 2 |
Mineralization, Focal | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst, Multiple | 2 |
Hemorrhage | 2 |
Hyperplasia, Focal | 1 |
Vacuolization Cytoplasmic, Focal | 2 2 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 |
Bilateral, Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 3 2 3|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + M +|
Bilateral, Hyperplasia | 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 1 2 3 2 3 1|
Pars Nervosa, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 1 1 |
Follicle, Dilatation, Focal | 2 3 |
Follicular Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 1 2 3 2 2 1 3 2 2 2 3 2 1|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
Duct, Dilatation | 3 2 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 3 |
Atrophy | 2 2 2 2 2 |
Inflammation, Chronic, Focal | 2|
Inflammation, Focal, Granulomatous | 3 |
Inflammation, Focal, Suppurative | 2 1 |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 4| 7| 5| 7| 7|
DAY ON TEST | 2| 0| 2| 3| 0| 2| 1| 2| 2| 2| 2| 1| 3| 8| 0| 2| 2| 6| 9| 2| 5| 2| 0| 2| 2|
| 9| 2| 9| 2| 1| 9| 0| 9| 9| 9| 9| 4| 1| 0| 6| 9| 9| 8| 2| 9| 0| 2| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 2 3 3 |
Interstitial Cell, Hyperplasia, Focal| 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Axillary, Hyperplasia, Plasma Cell | |
Iliac, Cyst | |
Iliac, Infiltration Cellular, | |
Histiocyte | |
Inguinal, Cyst | |
Lumbar, Hemorrhage | 3 |
Lumbar, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Hemorrhage | 2 3 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Hemorrhage | 3 3 |
Renal, Hemorrhage | |
Renal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Hemorrhage | 2 3 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +|
Fibrosis, Focal | 2 2 |
Hematopoietic Cell Proliferation | |
Capsule, Cyst | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Galactocele | |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 4| 7| 5| 7| 7|
DAY ON TEST | 2| 0| 2| 3| 0| 2| 1| 2| 2| 2| 2| 1| 3| 8| 0| 2| 2| 6| 9| 2| 5| 2| 0| 2| 2|
| 9| 2| 9| 2| 1| 9| 0| 9| 9| 9| 9| 4| 1| 0| 6| 9| 9| 8| 2| 9| 0| 2| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Pigmentation, Focal | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Acute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis, Focal | 2|
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage, Focal | |
Infiltration Cellular, Focal, | |
Histiocyte | |
Inflammation, Focal | 1 3 2 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 2 |
Fungus | 3 3 3 2 3 3 3 |
Hemorrhage | |
Inflammation, Chronic Active | 3 4 3 2 3 3 3 |
Inflammation, Subacute | 1 1 |
Glands, Dilatation, Focal | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | M + + + + + + + + + + + + + + + + + M + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 4| 7| 5| 7| 7|
DAY ON TEST | 2| 0| 2| 3| 0| 2| 1| 2| 2| 2| 2| 1| 3| 8| 0| 2| 2| 6| 9| 2| 5| 2| 0| 2| 2|
| 9| 2| 9| 2| 1| 9| 0| 9| 9| 9| 9| 4| 1| 0| 6| 9| 9| 8| 2| 9| 0| 2| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infarct | 4 |
Mineralization, Focal | |
Nephropathy | 3 2 4 2 3 3 3 3 3 2 2 1 2 2 3 3 2 3 3 1 4 2 2|
Pigmentation, Focal | 3 1 2 3 1 2 1 2 2 2 2 2 |
Pelvis, Inflammation, Suppurative | |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
10000PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 47 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Focal | | 2 2.0|
Basophilic Focus | | 18 |
Clear Cell Focus | | 17 |
Congestion | | 1 2.0|
Degeneration, Cystic, Focal | | 25 1.6|
Eosinophilic Focus | | 20 |
Fatty Change, Focal | | 16 1.5|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic, Focal | | 2 1.5|
Mixed Cell Focus | | 7 |
Necrosis, Focal | | 3 2.3|
Pigmentation, Focal | | 1 2.0|
Bile Duct, Cyst | | 1 1.0|
Bile Duct, Fibrosis | | 1 4.0|
Bile Duct, Hyperplasia, Focal | | 2 3.0|
Centrilobular, Atrophy, Focal | | 1 2.0|
Vein, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis, Focal | | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Atrophy, Diffuse | | 1 4.0|
Acinus, Atrophy, Focal | | 26 1.7|
Acinus, Cytoplasmic Alteration, Focal| | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 9 |
Palate, Hyperplasia, Focal, Squamous | | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Acanthosis, Focal | | 1 1.0|
Hyperplasia, Basal Cell, Focal | | 19 1.4|
Hyperplasia, Focal, Plasma Cell | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
10000PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Focal, Squamous | | 4 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Erosion, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 32 1.9|
Mineralization, Focal | | 1 2.0|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 50 |
Congestion | | 1 3.0|
Cyst, Multiple | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Focal | | 2 1.5|
Vacuolization Cytoplasmic, Focal | | 12 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | | 50 |
Hyperplasia | | 8 1.9|
Bilateral, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia, Focal | | 10 2.6|
__________________________________________________________________________|____________|
Parathyroid Gland | | 45 |
Bilateral, Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Hyperplasia, Focal | | 18 1.8|
Pars Nervosa, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia, Focal | | 4 1.0|
Follicle, Dilatation, Focal | | 4 2.5|
Follicular Cell, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
Degeneration, Focal | | 33 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
10000PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Duct, Dilatation | | 11 2.4|
__________________________________________________________________________|____________|
Prostate | | 49 |
Abscess | | 2 3.0|
Atrophy | | 13 2.1|
Inflammation, Chronic, Focal | | 4 2.3|
Inflammation, Focal, Granulomatous | | 2 2.5|
Inflammation, Focal, Suppurative | | 4 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | | 49 |
Abscess | | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Atrophy | | 9 3.2|
Interstitial Cell, Hyperplasia, Focal| | 5 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Hyperplasia | | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node | | 18 |
Axillary, Hyperplasia, Plasma Cell | | 1 2.0|
Iliac, Cyst | | 1 |
Iliac, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Inguinal, Cyst | | 1 |
Lumbar, Hemorrhage | | 2 2.5|
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Mediastinal, Hemorrhage | | 2 2.5|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Pancreatic, Hemorrhage | | 2 3.0|
Renal, Hemorrhage | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Cyst | | 3 3.0|
Hemorrhage | | 2 2.5|
Hyperplasia, Plasma Cell | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
10000PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 50 |
Hemorrhage | | 3 2.0|
__________________________________________________________________________|____________|
Spleen | | 49 |
Fibrosis, Focal | | 4 2.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Capsule, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 48 |
Congestion | | 1 3.0|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 46 |
Galactocele | | 1 3.0|
Hyperplasia, Focal | | 2 2.5|
Inflammation, Chronic, Focal | | 1 3.0|
Pigmentation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Fibrous Osteodystrophy | | 1 2.0|
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Gliosis, Focal | | 1 2.0|
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 3 2.7|
Hemorrhage, Focal | | 1 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | | 4 1.3|
Inflammation, Focal | | 7 1.9|
Alveolar Epithelium, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05130-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97
Route: DOSED FEED Time: 14:07:43
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
10000PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Focal | | 2 2.5|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 3 2.3|
Fungus | | 11 2.7|
Hemorrhage | | 1 2.0|
Inflammation, Chronic Active | | 14 2.7|
Inflammation, Subacute | | 3 1.3|
Glands, Dilatation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 1 2.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 48 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Cyst | | 2 2.5|
Infarct | | 1 4.0|
Mineralization, Focal | | 1 1.0|
Nephropathy | | 46 2.6|
Pigmentation, Focal | | 23 2.0|
Pelvis, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Abscess | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
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