TDMS Study 05133-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ACETONITRILE DATE: 05/20/95
EXPERIMENT: 05133 TEST: 04 TIME: 07:11:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES55073 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 000242
PATHOLOGIST: R. MILLER HAILEY, JAMES R. CAS: 75-05-8
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ACETONITRILE DATE: 05/20/95
EXPERIMENT: 05133 TEST: 04 TIME: 07:11:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES55073 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 000242
PATHOLOGIST: R. MILLER HAILEY, JAMES R. CAS: 75-05-8
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ACETONITRILE DATE: 05/20/95
EXPERIMENT: 05133 TEST: 04 TIME: 07:11:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES55073 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 000242
PATHOLOGIST: R. MILLER HAILEY, JAMES R. CAS: 75-05-8
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF ACETONITRILE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Malignant Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma: Benign, Complex, Malignant, NOS
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Pituitary Gland: Pars Intermedia
Adenoma
All Organs Benign Tumors
====================================================================================================
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/58 (3%) 4/60 (7%) 0/58 (0%) 1/60 (2%) | 0/59 (0%) 1/59 (2%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 6.3% 12.5% 0.0% 2.3% | 0.0% 3.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/32 (6%) 4/32 (13%) 0/32 (0%) 1/43 (2%) | 0/28 (0%) 1/33 (3%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) --- 733 (T) | --- 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.130N P=0.335 P=0.238N P=0.397N | P=0.555N P=0.533 (e) (e) |
|INCIDENTAL TUMOR | P=0.130N P=0.335 P=0.238N P=0.397N | P=0.555N P=0.533 (e) (e) |
|LOGISTIC REGRESSION | P=0.130N P=0.335 P=0.238N P=0.397N | P=0.555N P=0.533 (e) (e) |
|COCHRAN-ARMITAGE | P=0.194N | P=0.567N |
|FISHER EXACT | P=0.356 P=0.248N P=0.487N | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/59 (2%) 0/60 (0%) 1/57 (2%) 0/60 (0%) | 2/58 (3%) 0/58 (0%) 0/60 (0%) 0/58 (0%) |
|ADJUSTED (b) | 2.9% 0.0% 3.1% 0.0% | 5.3% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/32 (0%) 1/32 (3%) 0/43 (0%) | 1/27 (4%) 0/33 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 714 --- 733 (T) --- | 426 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.353N P=0.512N P=0.757 P=0.454N | P=0.111N P=0.218N P=0.230N P=0.225N |
|INCIDENTAL TUMOR | P=0.422N P=0.450N P=0.746N P=0.612N | P=0.082N P=0.325N P=0.486N P=0.151N |
|LOGISTIC REGRESSION | P=0.367N P=0.497N P=0.763N P=0.471N | P=0.102N P=0.247N P=0.251N P=0.215N |
|COCHRAN-ARMITAGE | P=0.404N | P=0.114N |
|FISHER EXACT | P=0.496N P=0.743 P=0.496N | P=0.248N P=0.239N P=0.248N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/59 (2%) 0/60 (0%) 1/57 (2%) 0/60 (0%) | 3/58 (5%) 0/58 (0%) 0/60 (0%) 0/58 (0%) |
|ADJUSTED (b) | 2.9% 0.0% 3.1% 0.0% | 9.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/32 (0%) 1/32 (3%) 0/43 (0%) | 2/27 (7%) 0/33 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 714 --- 733 (T) --- | 426 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.353N P=0.512N P=0.757 P=0.454N | P=0.044N* P=0.100N P=0.113N P=0.105N |
|INCIDENTAL TUMOR | P=0.422N P=0.450N P=0.746N P=0.612N | P=0.033N* P=0.150N P=0.222N P=0.069N |
|LOGISTIC REGRESSION | P=0.367N P=0.497N P=0.763N P=0.471N | P=0.045N* P=0.123N P=0.120N P=0.118N |
|COCHRAN-ARMITAGE | P=0.404N | P=0.047N* |
|FISHER EXACT | P=0.496N P=0.743 P=0.496N | P=0.122N P=0.116N P=0.122N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 4/60 (7%) 1/60 (2%) 2/60 (3%) | 3/59 (5%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 11.9% 11.4% 3.1% 4.5% | 8.3% 3.0% 3.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/32 (6%) 3/32 (9%) 1/32 (3%) 1/43 (2%) | 1/28 (4%) 1/33 (3%) 1/29 (3%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 437 602 733 (T) 727 | 623 735 (T) 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.073N P=0.492N P=0.106N P=0.156N | P=0.071N P=0.283N P=0.296N P=0.125N |
|INCIDENTAL TUMOR | P=0.157N P=0.556N P=0.144N P=0.422N | P=0.086N P=0.299N P=0.292N P=0.200N |
|LOGISTIC REGRESSION | P=0.108N P=0.500N P=0.105N P=0.231N | P=0.074N P=0.295N P=0.287N P=0.125N |
|COCHRAN-ARMITAGE | P=0.115N | P=0.072N |
|FISHER EXACT | P=0.500N P=0.103N P=0.219N | P=0.303N P=0.303N P=0.119N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 4/60 (7%) 1/60 (2%) 2/60 (3%) | 3/59 (5%) 1/60 (2%) 2/60 (3%) 1/60 (2%) |
|ADJUSTED (b) | 11.9% 11.4% 3.1% 4.5% | 8.3% 3.0% 6.9% 3.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/32 (6%) 3/32 (9%) 1/32 (3%) 1/43 (2%) | 1/28 (4%) 1/33 (3%) 2/29 (7%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 437 602 733 (T) 727 | 623 735 (T) 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.073N P=0.492N P=0.106N P=0.156N | P=0.266N P=0.283N P=0.485N P=0.298N |
|INCIDENTAL TUMOR | P=0.157N P=0.556N P=0.144N P=0.422N | P=0.307N P=0.299N P=0.481N P=0.405N |
|LOGISTIC REGRESSION | P=0.108N P=0.500N P=0.105N P=0.231N | P=0.287N P=0.295N P=0.472N P=0.316N |
|COCHRAN-ARMITAGE | P=0.115N | P=0.275N |
|FISHER EXACT | P=0.500N P=0.103N P=0.219N | P=0.303N P=0.492N P=0.303N |
|=================================================================================================================================|
| |
|Intestine Small: Site Unspecified |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 1/60 (2%) | 0/59 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 6.3% 0.0% 0.0% 2.3% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/32 (6%) 0/32 (0%) 0/32 (0%) 1/43 (2%) | 0/28 (0%) 0/33 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- 733 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.384N P=0.238N P=0.238N P=0.397N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.384N P=0.238N P=0.238N P=0.397N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.384N P=0.238N P=0.238N P=0.397N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.461N | (e) |
|FISHER EXACT | P=0.248N P=0.248N P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/57 (0%) 1/60 (2%) 0/58 (0%) 1/60 (2%) | 0/59 (0%) 0/59 (0%) 2/60 (3%) 0/57 (0%) |
|ADJUSTED (b) | 0.0% 2.6% 0.0% 2.3% | 0.0% 0.0% 6.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/31 (0%) 0/32 (0%) 0/32 (0%) 1/43 (2%) | 0/28 (0%) 0/33 (0%) 2/29 (7%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- 664 --- 733 (T) | --- --- 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.465 P=0.505 (e) P=0.565 | P=0.611 (e) P=0.246 (e) |
|INCIDENTAL TUMOR | P=0.393 P=0.581 (e) P=0.565 | P=0.611 (e) P=0.246 (e) |
|LOGISTIC REGRESSION | P=0.434 P=0.511 (e) P=0.565 | P=0.611 (e) P=0.246 (e) |
|COCHRAN-ARMITAGE | P=0.413 | P=0.589 |
|FISHER EXACT | P=0.513 (e) P=0.513 | (e) P=0.252 (e) |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/60 (5%) 1/59 (2%) 3/60 (5%) | 0/59 (0%) 0/60 (0%) 1/60 (2%) 1/59 (2%) |
|ADJUSTED (b) | 3.0% 9.4% 2.9% 6.4% | 0.0% 0.0% 3.4% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 3/32 (9%) 0/32 (0%) 0/43 (0%) | 0/28 (0%) 0/33 (0%) 1/29 (3%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 729 733 (T) 720 554 | --- --- 735 (T) 509 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.431 P=0.304 P=0.760 P=0.387 | P=0.236 (e) P=0.507 P=0.487 |
|INCIDENTAL TUMOR | P=0.203 P=0.329 P=0.738N P=0.076 | P=0.360 (e) P=0.507 P=0.638 |
|LOGISTIC REGRESSION | P=0.360 P=0.295 P=0.763 P=0.316 | P=0.244 (e) P=0.507 P=0.561 |
|COCHRAN-ARMITAGE | P=0.313 | P=0.234 |
|FISHER EXACT | P=0.309 P=0.748 P=0.309 | (e) P=0.504 P=0.500 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/60 (25%) 13/60 (22%) 20/59 (34%) 11/60 (18%) | 4/59 (7%) 10/60 (17%) 9/60 (15%) 6/59 (10%) |
|ADJUSTED (b) | 37.2% 32.6% 50.9% 23.5% | 12.0% 25.1% 26.8% 18.8% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 1/10 (10%) 2/10 (20%) 1/10 (10%) | 0/10 (0%) 2/10 (20%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 9/32 (28%) 8/32 (25%) 14/32 (44%) 8/43 (19%) | 2/28 (7%) 6/33 (18%) 6/29 (21%) 6/32 (19%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 434 456 (I) 456 (I) | 569 457 (I) 457 (I) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.099N P=0.410N P=0.223 P=0.097N | P=0.535 P=0.118 P=0.144 P=0.433 |
|INCIDENTAL TUMOR | P=0.264N P=0.439N P=0.222 P=0.257N | P=0.453 P=0.084 P=0.152 P=0.351 |
|LOGISTIC REGRESSION | P=0.244N P=0.411N P=0.201 P=0.210N | P=0.453 P=0.083 P=0.141 P=0.352 |
|COCHRAN-ARMITAGE | P=0.300N | P=0.483 |
|FISHER EXACT | P=0.415N P=0.194 P=0.253N | P=0.081 P=0.126 P=0.371 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/60 (13%) 14/60 (23%) 13/59 (22%) 7/60 (12%) | 7/59 (12%) 6/60 (10%) 6/60 (10%) 5/59 (8%) |
|ADJUSTED (b) | 16.5% 28.5% 30.1% 15.0% | 23.1% 15.8% 16.4% 13.6% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 3/10 (30%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/32 (3%) 1/32 (3%) 4/32 (13%) 4/43 (9%) | 5/28 (18%) 3/33 (9%) 2/29 (7%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | 437 456 (I) 342 532 | 706 595 570 510 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.183N P=0.150 P=0.201 P=0.374N | P=0.309N P=0.397N P=0.456N P=0.323N |
|INCIDENTAL TUMOR | P=0.339 P=0.088 P=0.105 P=0.331 | P=0.410N P=0.508N P=0.413N P=0.394N |
|LOGISTIC REGRESSION | P=0.486 P=0.068 P=0.138 P=0.427 | P=0.355N P=0.469N P=0.447N P=0.404N |
|COCHRAN-ARMITAGE | P=0.305N | P=0.333N |
|FISHER EXACT | P=0.119 P=0.158 P=0.500N | P=0.487N P=0.487N P=0.381N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/60 (37%) 25/60 (42%) 32/59 (54%) 16/60 (27%) | 9/59 (15%) 15/60 (25%) 14/60 (23%) 10/59 (17%) |
|ADJUSTED (b) | 47.1% 50.2% 68.7% 33.0% | 28.0% 35.8% 37.9% 28.5% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 4/10 (40%) 2/10 (20%) 1/10 (10%) | 0/10 (0%) 2/10 (20%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 10/32 (31%) 9/32 (28%) 18/32 (56%) 11/43 (26%) | 6/28 (21%) 8/33 (24%) 8/29 (28%) 8/32 (25%) |
|FIRST INCIDENCE (DAYS) | 437 434 342 456 (I) | 569 457 (I) 457 (I) 510 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.034N* P=0.388 P=0.086 P=0.054N | P=0.450N P=0.217 P=0.222 P=0.585 |
|INCIDENTAL TUMOR | P=0.303N P=0.333 P=0.037 * P=0.324N | P=0.510 P=0.130 P=0.236 P=0.493 |
|LOGISTIC REGRESSION | P=0.212N P=0.344 P=0.042 * P=0.164N | P=0.544 P=0.139 P=0.217 P=0.465 |
|COCHRAN-ARMITAGE | P=0.139N | P=0.504N |
|FISHER EXACT | P=0.354 P=0.041 * P=0.163N | P=0.136 P=0.189 P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/60 (37%) 25/60 (42%) 32/59 (54%) 16/60 (27%) | 9/59 (15%) 15/60 (25%) 14/60 (23%) 10/59 (17%) |
|ADJUSTED (b) | 47.1% 50.2% 68.7% 33.0% | 28.0% 35.8% 37.9% 28.5% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 4/10 (40%) 2/10 (20%) 1/10 (10%) | 0/10 (0%) 2/10 (20%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 10/32 (31%) 9/32 (28%) 18/32 (56%) 11/43 (26%) | 6/28 (21%) 8/33 (24%) 8/29 (28%) 8/32 (25%) |
|FIRST INCIDENCE (DAYS) | 437 434 342 456 (I) | 569 457 (I) 457 (I) 510 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.034N* P=0.388 P=0.086 P=0.054N | P=0.450N P=0.217 P=0.222 P=0.585 |
|INCIDENTAL TUMOR | P=0.303N P=0.333 P=0.037 * P=0.324N | P=0.510 P=0.130 P=0.236 P=0.493 |
|LOGISTIC REGRESSION | P=0.212N P=0.344 P=0.042 * P=0.164N | P=0.544 P=0.139 P=0.217 P=0.465 |
|COCHRAN-ARMITAGE | P=0.139N | P=0.504N |
|FISHER EXACT | P=0.354 P=0.041 * P=0.163N | P=0.136 P=0.189 P=0.500 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 12/60 (20%) 10/58 (17%) 21/60 (35%) | 7/59 (12%) 2/60 (3%) 4/60 (7%) 1/59 (2%) |
|ADJUSTED (b) | 20.1% 31.8% 26.8% 41.3% | 25.0% 6.1% 10.0% 1.8% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 3/10 (30%) 2/10 (20%) 3/10 (30%) | 0/10 (0%) 0/10 (0%) 2/10 (20%) 1/10 (10%) |
|TERMINAL (d) | 6/32 (19%) 9/32 (28%) 7/32 (22%) 14/43 (33%) | 7/28 (25%) 2/33 (6%) 2/29 (7%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 456 (I) 456 (I) | 735 (T) 735 (T) 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.016 * P=0.151 P=0.298 P=0.019 * | P=0.030N* P=0.044N* P=0.243N P=0.021N* |
|INCIDENTAL TUMOR | P=0.007 ** P=0.151 P=0.304 P=0.005 ** | P=0.030N* P=0.044N* P=0.243N P=0.021N* |
|LOGISTIC REGRESSION | P=0.005 ** P=0.162 P=0.290 P=0.003 ** | P=0.040N* P=0.044N* P=0.238N P=0.036N* |
|COCHRAN-ARMITAGE | P=0.002 ** | P=0.038N* |
|FISHER EXACT | P=0.159 P=0.275 P=0.002 ** | P=0.077N P=0.255N P=0.031N* |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 7/60 (12%) 6/58 (10%) 4/60 (7%) | 1/59 (2%) 1/60 (2%) 0/60 (0%) 1/59 (2%) |
|ADJUSTED (b) | 15.1% 17.9% 16.4% 9.3% | 3.1% 3.0% 0.0% 3.1% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/32 (9%) 4/32 (13%) 3/32 (9%) 4/43 (9%) | 0/28 (0%) 1/33 (3%) 0/29 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 607 733 (T) | 706 735 (T) --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.147N P=0.505 P=0.614N P=0.238N | P=0.599N P=0.732N P=0.482N P=0.739N |
|INCIDENTAL TUMOR | P=0.247N P=0.521 P=0.595N P=0.281N | P=0.641N P=0.736 P=0.443N P=0.703 |
|LOGISTIC REGRESSION | P=0.242N P=0.500 P=0.604 P=0.351N | P=0.620N P=0.752N P=0.487N P=0.760 |
|COCHRAN-ARMITAGE | P=0.267N | P=0.617N |
|FISHER EXACT | P=0.500 P=0.595 P=0.372N | P=0.748N P=0.496N P=0.752N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/60 (20%) 17/60 (28%) 16/58 (28%) 24/60 (40%) | 8/59 (14%) 3/60 (5%) 4/60 (7%) 2/59 (3%) |
|ADJUSTED (b) | 32.7% 43.4% 40.6% 47.4% | 27.3% 9.1% 10.0% 4.9% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 3/10 (30%) 2/10 (20%) 3/10 (30%) | 0/10 (0%) 0/10 (0%) 2/10 (20%) 1/10 (10%) |
|TERMINAL (d) | 9/32 (28%) 12/32 (38%) 10/32 (31%) 17/43 (40%) | 7/28 (25%) 3/33 (9%) 2/29 (7%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 456 (I) 456 (I) | 706 735 (T) 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.109 P=0.195 P=0.262 P=0.095 | P=0.038N* P=0.057N P=0.163N P=0.032N* |
|INCIDENTAL TUMOR | P=0.034 * P=0.203 P=0.276 P=0.031 * | P=0.041N* P=0.066N P=0.155N P=0.041N* |
|LOGISTIC REGRESSION | P=0.019 * P=0.199 P=0.246 P=0.021 * | P=0.052N P=0.065N P=0.158N P=0.053N |
|COCHRAN-ARMITAGE | P=0.012 * | P=0.049N* |
|FISHER EXACT | P=0.197 P=0.226 P=0.014 * | P=0.097N P=0.173N P=0.047N* |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 3/59 (5%) 0/60 (0%) 3/60 (5%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 8.9% 0.0% 7.8% 3.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/32 (0%) 0/32 (0%) 0/43 (0%) | 1/28 (4%) 0/33 (0%) 0/29 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 641 --- 650 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.358N P=0.109N P=0.612N P=0.283N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.492N P=0.127N P=0.585N P=0.405N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.384N P=0.116N P=0.639N P=0.316N |
|COCHRAN-ARMITAGE | (e) | P=0.368N |
|FISHER EXACT | (e) (e) (e) | P=0.119N P=0.652N P=0.303N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 1/58 (2%) 2/57 (4%) 1/58 (2%) 1/57 (2%) |
|ADJUSTED (b) | | 3.7% 6.1% 3.6% 3.2% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | | 1/27 (4%) 2/33 (6%) 1/28 (4%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | | 735 (T) 735 (T) 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.506N P=0.570 P=0.754N P=0.731N |
|INCIDENTAL TUMOR | | P=0.506N P=0.570 P=0.754N P=0.731N |
|LOGISTIC REGRESSION | | P=0.506N P=0.570 P=0.754N P=0.731N |
|COCHRAN-ARMITAGE | | P=0.534N |
|FISHER EXACT | | P=0.493 P=0.752N P=0.748 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/56 (0%) 0/58 (0%) 0/56 (0%) 0/59 (0%) | 14/58 (24%) 14/59 (24%) 15/60 (25%) 6/58 (10%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 41.8% 38.3% 42.2% 17.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/29 (0%) 0/31 (0%) 0/32 (0%) 0/42 (0%) | 9/27 (33%) 11/33 (33%) 10/29 (34%) 4/32 (13%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 622 646 583 664 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.023N* P=0.406N P=0.582N P=0.027N* |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.038N* P=0.530N P=0.532N P=0.067N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.030N* P=0.507N P=0.556N P=0.039N* |
|COCHRAN-ARMITAGE | (e) | P=0.034N* |
|FISHER EXACT | (e) (e) (e) | P=0.565N P=0.542 P=0.042N* |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/56 (2%) 0/58 (0%) 0/56 (0%) 1/59 (2%) | 0/58 (0%) 0/59 (0%) 0/60 (0%) 2/58 (3%) |
|ADJUSTED (b) | 3.4% 0.0% 0.0% 2.4% | 0.0% 0.0% 0.0% 6.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/29 (3%) 0/31 (0%) 0/32 (0%) 1/42 (2%) | 0/27 (0%) 0/33 (0%) 0/29 (0%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- 733 (T) | --- --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.666 P=0.487N P=0.480N P=0.677N | P=0.052 (e) (e) P=0.276 |
|INCIDENTAL TUMOR | P=0.666 P=0.487N P=0.480N P=0.677N | P=0.052 (e) (e) P=0.276 |
|LOGISTIC REGRESSION | P=0.666 P=0.487N P=0.480N P=0.677N | P=0.052 (e) (e) P=0.276 |
|COCHRAN-ARMITAGE | P=0.603 | P=0.045 * |
|FISHER EXACT | P=0.491N P=0.500N P=0.739N | (e) (e) P=0.248 |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/59 (0%) 0/60 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 2.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 6.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/32 (0%) 0/32 (0%) 0/43 (0%) | 0/28 (0%) 0/33 (0%) 1/29 (3%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 457 --- --- --- | --- --- 671 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.303N P=0.504N P=0.500N P=0.496N | P=0.596 (e) P=0.244 (e) |
|INCIDENTAL TUMOR | P=0.458N P=0.581N P=0.718N P=0.718N | P=0.564 (e) P=0.275 (e) |
|LOGISTIC REGRESSION | P=0.317N P=0.488N P=0.464N P=0.549N | P=0.589 (e) P=0.251 (e) |
|COCHRAN-ARMITAGE | P=0.306N | P=0.598 |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | (e) P=0.252 (e) |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 0/60 (0%) 0/58 (0%) 1/60 (2%) | 2/59 (3%) 0/59 (0%) 0/60 (0%) 1/58 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 2.3% | 6.8% 0.0% 0.0% 3.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/32 (0%) 0/32 (0%) 1/43 (2%) | 1/28 (4%) 0/33 (0%) 0/29 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 733 (T) | 710 --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.244 (e) (e) P=0.559 | P=0.440N P=0.206N P=0.226N P=0.455N |
|INCIDENTAL TUMOR | P=0.244 (e) (e) P=0.559 | P=0.481N P=0.264N P=0.205N P=0.547N |
|LOGISTIC REGRESSION | P=0.244 (e) (e) P=0.559 | P=0.460N P=0.225N P=0.220N P=0.497N |
|COCHRAN-ARMITAGE | P=0.200 | P=0.465N |
|FISHER EXACT | (e) (e) P=0.504 | P=0.248N P=0.244N P=0.506N |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 2/60 (3%) | 1/59 (2%) 0/60 (0%) 1/60 (2%) 3/60 (5%) |
|ADJUSTED (b) | 0.0% 0.0% 3.1% 4.7% | 3.6% 0.0% 3.4% 9.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/32 (0%) 1/32 (3%) 2/43 (5%) | 1/28 (4%) 0/33 (0%) 1/29 (3%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | --- --- 733 (T) 733 (T) | 735 (T) --- 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.113 (e) P=0.500 P=0.306 | P=0.108 P=0.467N P=0.754N P=0.353 |
|INCIDENTAL TUMOR | P=0.113 (e) P=0.500 P=0.306 | P=0.108 P=0.467N P=0.754N P=0.353 |
|LOGISTIC REGRESSION | P=0.113 (e) P=0.500 P=0.306 | P=0.108 P=0.467N P=0.754N P=0.353 |
|COCHRAN-ARMITAGE | P=0.070 | P=0.099 |
|FISHER EXACT | (e) P=0.500 P=0.248 | P=0.496N P=0.748N P=0.316 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/59 (3%) 2/60 (3%) 0/58 (0%) 0/60 (0%) | 2/59 (3%) 3/58 (5%) 2/60 (3%) 1/59 (2%) |
|ADJUSTED (b) | 6.3% 3.4% 0.0% 0.0% | 7.1% 8.3% 6.4% 3.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 2/10 (20%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/32 (6%) 0/32 (0%) 0/32 (0%) 0/43 (0%) | 2/28 (7%) 2/33 (6%) 1/29 (3%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 456 (I) --- --- | 735 (T) 639 712 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.073N P=0.695 P=0.238N P=0.176N | P=0.287N P=0.562 P=0.673N P=0.453N |
|INCIDENTAL TUMOR | P=0.073N P=0.695 P=0.238N P=0.176N | P=0.337N P=0.574 P=0.659N P=0.453N |
|LOGISTIC REGRESSION | P=0.097N P=0.692N P=0.238N P=0.176N | P=0.317N P=0.514 P=0.667N P=0.453N |
|COCHRAN-ARMITAGE | P=0.086N | P=0.310N |
|FISHER EXACT | P=0.684N P=0.252N P=0.244N | P=0.492 P=0.684N P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/59 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | | 5.5% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/28 (0%) 0/33 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | | 622 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.113N P=0.225N P=0.222N P=0.236N |
|INCIDENTAL TUMOR | | P=0.149N P=0.265N P=0.227N P=0.401N |
|LOGISTIC REGRESSION | | P=0.114N P=0.234N P=0.232N P=0.241N |
|COCHRAN-ARMITAGE | | P=0.113N |
|FISHER EXACT | | P=0.244N P=0.244N P=0.244N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/59 (3%) 2/60 (3%) 3/60 (5%) 3/60 (5%) |
|ADJUSTED (b) | | 6.9% 6.1% 9.1% 9.4% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 1/28 (4%) 2/33 (6%) 2/29 (7%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | | 720 735 (T) 664 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.404 P=0.637N P=0.524 P=0.560 |
|INCIDENTAL TUMOR | | P=0.360 P=0.687N P=0.562 P=0.488 |
|LOGISTIC REGRESSION | | P=0.367 P=0.662N P=0.534 P=0.530 |
|COCHRAN-ARMITAGE | | P=0.378 |
|FISHER EXACT | | P=0.684N P=0.508 P=0.508 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/59 (3%) 3/60 (5%) 3/60 (5%) 3/60 (5%) |
|ADJUSTED (b) | | 6.9% 8.3% 9.1% 9.4% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 1/28 (4%) 2/33 (6%) 2/29 (7%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | | 720 639 664 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.468 P=0.558 P=0.524 P=0.560 |
|INCIDENTAL TUMOR | | P=0.397 P=0.522 P=0.562 P=0.488 |
|LOGISTIC REGRESSION | | P=0.423 P=0.519 P=0.534 P=0.530 |
|COCHRAN-ARMITAGE | | P=0.444 |
|FISHER EXACT | | P=0.508 P=0.508 P=0.508 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/60 (3%) 1/60 (2%) 2/60 (3%) | 2/59 (3%) 2/60 (3%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 3.1% 6.3% 3.1% 4.7% | 7.1% 6.1% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/32 (3%) 2/32 (6%) 1/32 (3%) 2/43 (5%) | 2/28 (7%) 2/33 (6%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) 733 (T) 733 (T) | 735 (T) 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.561 P=0.500 P=0.762 P=0.603 | P=0.077N P=0.635N P=0.230N P=0.209N |
|INCIDENTAL TUMOR | P=0.561 P=0.500 P=0.762 P=0.603 | P=0.077N P=0.635N P=0.230N P=0.209N |
|LOGISTIC REGRESSION | P=0.561 P=0.500 P=0.762 P=0.603 | P=0.077N P=0.635N P=0.230N P=0.209N |
|COCHRAN-ARMITAGE | P=0.444 | P=0.085N |
|FISHER EXACT | P=0.500 P=0.752N P=0.500 | P=0.684N P=0.244N P=0.244N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 4/60 (7%) 1/60 (2%) 5/60 (8%) | 3/59 (5%) 0/60 (0%) 1/60 (2%) 3/60 (5%) |
|ADJUSTED (b) | 5.9% 11.3% 2.9% 10.7% | 8.9% 0.0% 3.4% 8.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 3/32 (9%) 0/32 (0%) 2/43 (5%) | 1/28 (4%) 0/33 (0%) 1/29 (3%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 716 583 720 554 | 622 --- 735 (T) 509 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.339 P=0.338 P=0.500N P=0.331 | P=0.438 P=0.107N P=0.288N P=0.632N |
|INCIDENTAL TUMOR | P=0.112 P=0.367 P=0.450N P=0.067 | P=0.444 P=0.127N P=0.292N P=0.643 |
|LOGISTIC REGRESSION | P=0.255 P=0.341 P=0.499N P=0.252 | P=0.411 P=0.116N P=0.284N P=0.653 |
|COCHRAN-ARMITAGE | P=0.212 | P=0.428 |
|FISHER EXACT | P=0.340 P=0.500N P=0.219 | P=0.119N P=0.303N P=0.652N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 6/60 (10%) 2/60 (3%) 7/60 (12%) | 5/59 (8%) 2/60 (3%) 1/60 (2%) 3/60 (5%) |
|ADJUSTED (b) | 8.8% 17.4% 6.0% 15.1% | 15.7% 6.1% 3.4% 8.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/32 (3%) 5/32 (16%) 1/32 (3%) 4/43 (9%) | 3/28 (11%) 2/33 (6%) 1/29 (3%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 716 583 720 554 | 622 735 (T) 735 (T) 509 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.340 P=0.245 P=0.500N P=0.290 | P=0.295N P=0.168N P=0.095N P=0.317N |
|INCIDENTAL TUMOR | P=0.151 P=0.265 P=0.463N P=0.079 | P=0.293N P=0.187N P=0.097N P=0.356N |
|LOGISTIC REGRESSION | P=0.250 P=0.245 P=0.454N P=0.210 | P=0.332N P=0.198N P=0.088N P=0.373N |
|COCHRAN-ARMITAGE | P=0.181 | P=0.313N |
|FISHER EXACT | P=0.245 P=0.500N P=0.161 | P=0.213N P=0.100N P=0.349N |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 0/60 (0%) | 2/59 (3%) 1/60 (2%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 3.1% 0.0% 0.0% | 5.8% 3.0% 2.4% 2.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 1/32 (3%) 0/32 (0%) 0/43 (0%) | 1/28 (4%) 1/33 (3%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) --- --- | 623 735 (T) 665 664 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.519N P=0.500 (e) (e) | P=0.409N P=0.465N P=0.474N P=0.499N |
|INCIDENTAL TUMOR | P=0.519N P=0.500 (e) (e) | P=0.498N P=0.444N P=0.484N P=0.641N |
|LOGISTIC REGRESSION | P=0.519N P=0.500 (e) (e) | P=0.418N P=0.489N P=0.488N P=0.507N |
|COCHRAN-ARMITAGE | P=0.567N | P=0.405N |
|FISHER EXACT | P=0.500 (e) (e) | P=0.494N P=0.494N P=0.494N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 4/60 (7%) 4/60 (7%) 2/60 (3%) | 14/59 (24%) 18/60 (30%) 17/60 (28%) 15/60 (25%) |
|ADJUSTED (b) | 8.9% 11.6% 10.6% 4.7% | 37.8% 42.8% 42.3% 42.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/32 (6%) 2/32 (6%) 1/32 (3%) 2/43 (5%) | 7/28 (25%) 10/33 (30%) 8/29 (28%) 12/32 (38%) |
|FIRST INCIDENCE (DAYS) | 714 700 644 733 (T) | 457 (I) 369 552 444 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.243N P=0.493 P=0.504 P=0.374N | P=0.486N P=0.407 P=0.418 P=0.570N |
|INCIDENTAL TUMOR | P=0.415N P=0.559 P=0.531 P=0.442N | P=0.395 P=0.262 P=0.455 P=0.407 |
|LOGISTIC REGRESSION | P=0.293N P=0.502 P=0.505 P=0.400N | P=0.487 P=0.292 P=0.411 P=0.454 |
|COCHRAN-ARMITAGE | P=0.368N | P=0.521N |
|FISHER EXACT | P=0.500 P=0.500 P=0.500N | P=0.286 P=0.358 P=0.521 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 4/60 (7%) 2/60 (3%) | 12/59 (20%) 17/60 (28%) 16/60 (27%) 14/60 (23%) |
|ADJUSTED (b) | 8.9% 8.7% 10.6% 4.7% | 33.3% 40.4% 40.9% 40.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/32 (6%) 1/32 (3%) 1/32 (3%) 2/43 (5%) | 6/28 (21%) 9/33 (27%) 8/29 (28%) 12/32 (38%) |
|FIRST INCIDENCE (DAYS) | 714 700 644 733 (T) | 457 (I) 369 552 444 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.292N P=0.653 P=0.504 P=0.374N | P=0.525 P=0.318 P=0.330 P=0.513 |
|INCIDENTAL TUMOR | P=0.489N P=0.605N P=0.531 P=0.442N | P=0.352 P=0.177 P=0.363 P=0.368 |
|LOGISTIC REGRESSION | P=0.347N P=0.662N P=0.505 P=0.400N | P=0.418 P=0.215 P=0.311 P=0.368 |
|COCHRAN-ARMITAGE | P=0.421N | P=0.487 |
|FISHER EXACT | P=0.660N P=0.500 P=0.500N | P=0.211 P=0.275 P=0.431 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 26/60 (43%) 29/60 (48%) 28/60 (47%) 31/60 (52%) | 29/59 (49%) 27/60 (45%) 27/60 (45%) 19/60 (32%) |
|ADJUSTED (b) | 61.7% 68.9% 68.8% 61.5% | 73.4% 66.6% 65.6% 53.7% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 4/10 (40%) 3/10 (30%) 3/10 (30%) | 0/10 (0%) 2/10 (20%) 3/10 (30%) 1/10 (10%) |
|TERMINAL (d) | 17/32 (53%) 20/32 (63%) 20/32 (63%) 24/43 (56%) | 18/28 (64%) 20/33 (61%) 16/29 (55%) 16/32 (50%) |
|FIRST INCIDENCE (DAYS) | 437 434 456 (I) 456 (I) | 426 457 (I) 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.315N P=0.366 P=0.435 P=0.443N | P=0.021N* P=0.223N P=0.355N P=0.019N* |
|INCIDENTAL TUMOR | P=0.391 P=0.324 P=0.376 P=0.280 | P=0.041N* P=0.344N P=0.332N P=0.057N |
|LOGISTIC REGRESSION | P=0.413 P=0.359 P=0.439 P=0.312 | P=0.041N* P=0.361N P=0.313N P=0.050N* |
|COCHRAN-ARMITAGE | P=0.229 | P=0.030N* |
|FISHER EXACT | P=0.357 P=0.427 P=0.232 | P=0.394N P=0.394N P=0.039N* |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 21/60 (35%) 27/60 (45%) 19/60 (32%) 18/60 (30%) | 24/59 (41%) 23/60 (38%) 27/60 (45%) 24/60 (40%) |
|ADJUSTED (b) | 44.1% 54.8% 43.2% 37.4% | 57.2% 51.2% 60.4% 60.3% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 4/10 (40%) 0/10 (0%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 8/32 (25%) 11/32 (34%) 8/32 (25%) 13/43 (30%) | 11/28 (39%) 12/33 (36%) 12/29 (41%) 17/32 (53%) |
|FIRST INCIDENCE (DAYS) | 437 456 (I) 342 532 | 426 369 552 444 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.049N* P=0.223 P=0.420N P=0.142N | P=0.520N P=0.346N P=0.472 P=0.458N |
|INCIDENTAL TUMOR | P=0.379N P=0.173 P=0.405N P=0.565 | P=0.341 P=0.540N P=0.458 P=0.489 |
|LOGISTIC REGRESSION | P=0.250N P=0.166 P=0.424N P=0.344N | P=0.339 P=0.461N P=0.462 P=0.520 |
|COCHRAN-ARMITAGE | P=0.163N | P=0.508 |
|FISHER EXACT | P=0.176 P=0.423N P=0.348N | P=0.470N P=0.386 P=0.544N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05133 TEST: 04 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 50 PPM 100 PPM 200 PPM | CONTROL 50 PPM 100 PPM 200 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 36/60 (60%) 44/60 (73%) 40/60 (67%) 38/60 (63%) | 36/59 (61%) 38/60 (63%) 40/60 (67%) 33/60 (55%) |
|ADJUSTED (b) | 73.8% 84.1% 81.2% 72.8% | 79.6% 78.7% 81.0% 78.0% |
|INTERIM SACRIFICE 1 (c)| 4/10 (40%) 6/10 (60%) 3/10 (30%) 3/10 (30%) | 1/10 (10%) 2/10 (20%) 3/10 (30%) 1/10 (10%) |
|TERMINAL (d) | 20/32 (63%) 24/32 (75%) 23/32 (72%) 29/43 (67%) | 19/28 (68%) 23/33 (70%) 20/29 (69%) 23/32 (72%) |
|FIRST INCIDENCE (DAYS) | 437 434 342 456 (I) | 426 369 457 (I) 444 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.069N P=0.156 P=0.343 P=0.192N | P=0.248N P=0.438N P=0.442 P=0.241N |
|INCIDENTAL TUMOR | P=0.504 P=0.084 P=0.296 P=0.352 | P=0.439N P=0.428 P=0.428 P=0.517N |
|LOGISTIC REGRESSION | P=0.422N P=0.089 P=0.290 P=0.507 | P=0.379N P=0.486 P=0.422 P=0.453N |
|COCHRAN-ARMITAGE | P=0.518N | P=0.255N |
|FISHER EXACT | P=0.087 P=0.285 P=0.426 | P=0.471 P=0.326 P=0.316N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 456
Female interim sacrifices(days): 457
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).