TDMS Study 05133-04 Pathology Tables
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
Facility: Battelle Northwest
Chemical CAS #: 75-05-8
Lock Date: 07/17/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 7| 7| 4| 7| 6| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 5|
DAY ON TEST | 8| 3| 2| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 6|
| 1| 5| 6| 7| 5| 5| 7| 5| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5| 5| 2| 0| 5| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + A + + + + +|
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + M + + + A + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + A + + + + + + + + + + + + + + A|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + A + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X|
Degeneration, Cystic | |
Eosinophilic Focus | X |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 2 2 2 |
Hyperplasia, Lymphoid | |
Infarct | |
Mixed Cell Focus | |
Necrosis | 1 1 |
Bile Duct, Cyst | X |
Bile Duct, Degeneration | |
Centrilobular, Necrosis | |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Mesentery | + + + + |
Angiectasis | |
Inflammation, Chronic | 2 |
Fat, Necrosis | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Focal Cellular Change | 1 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | 4 1 |
Duct, Ectasia | 3 4|
Duct, Inflammation, Chronic | 3|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Squamous | 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 7| 7| 4| 7| 6| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 5|
DAY ON TEST | 8| 3| 2| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 6|
| 1| 5| 6| 7| 5| 5| 7| 5| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5| 5| 2| 0| 5| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + M + M + + + M + + + + + + + + M + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 |
Hyperplasia, Atypical | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 2 |
Hypertrophy | 1 |
Capsule, Hyperplasia | 4 |
__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + M M + M M M M M M M M M M M + + + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 1 1 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 2 4 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + M + + M + + + + M + + + M + + + + M M + +|
Atrophy | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | |
Angiectasis | 1 |
Atrophy | 3 2 2 2 2 2 1 2 4 |
Cyst | X X X X X X X X X |
Mineralization | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 7| 7| 4| 7| 6| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 5|
DAY ON TEST | 8| 3| 2| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 6|
| 1| 5| 6| 7| 5| 5| 7| 5| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5| 5| 2| 0| 5| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Amyloid Deposition | |
Hyperplasia, Cystic | 2 2 1 3 3 4 2 4 3 2 2 1 3 2 3 2 3 3 3 1 1 3 4 2 3|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + M + + + + M + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + M M + + + M + + M + + M + M|
Hyperplasia | 2 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + M + + +|
Angiectasis | |
Congestion | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Histiocytic | 4 |
Hyperplasia | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M M M + + M + + + I + + + M + M M + + M + M|
Hematopoietic Cell Proliferation | |
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 2 3 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Atrophy | 3 |
Hyperplasia, Lymphoid | 2 2 2 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3 3 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 7| 7| 4| 7| 6| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 5|
DAY ON TEST | 8| 3| 2| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 6|
| 1| 5| 6| 7| 5| 5| 7| 5| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5| 5| 2| 0| 5| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation | |
Mineralization | 1 1 1 1 1 1 1 2 2 1|
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 1 |
Inflammation, Acute | |
Inflammation, Suppurative | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Artery, Mediastinum, Inflammation | |
Mediastinum, Hemorrhage | 3 |
Mediastinum, Inflammation, | |
Suppurative | |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
Olfactory Epithelium, Atrophy | 2 |
Olfactory Epithelium, Metaplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hyperplasia, Atypical | 2 |
Inflammation, Suppurative | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 |
Arteriole, Inflammation, Chronic | 2 |
Cortex, Cyst | |
Cortex, Pigmentation, Hemosiderin | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 7| 7| 4| 7| 6| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 5|
DAY ON TEST | 8| 3| 2| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 6|
| 1| 5| 6| 7| 5| 5| 7| 5| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5| 5| 2| 0| 5| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Ulcer | |
Arteriole, Inflammation | |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 7| 7| 7| 4| 6| 7| 4| 6| 5| 6| 7| 0|
DAY ON TEST | 3| 3| 5| 0| 1| 3| 1| 3| 8| 5| 5| 4| 3| 3| 3| 3| 5| 3| 3| 5| 7| 8| 9| 0| 0|
| 5| 5| 7| 6| 0| 5| 7| 5| 1| 7| 8| 1| 5| 5| 5| 5| 7| 5| 5| 7| 8| 1| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + A + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + |
Hemorrhage | 1 |
Necrosis | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + |
Hemorrhage | 2 |
Necrosis | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + M + A + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | |
Degeneration, Cystic | 2 |
Eosinophilic Focus | X X X X |
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | 3 1 3 2 2 |
Hyperplasia, Lymphoid | 2 |
Infarct | 4 |
Mixed Cell Focus | X X X X |
Necrosis | 1 |
Bile Duct, Cyst | |
Bile Duct, Degeneration | 2 |
Centrilobular, Necrosis | 3 |
Serosa, Inflammation, Suppurative | 4 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Angiectasis | 2 |
Inflammation, Chronic | 3 |
Fat, Necrosis | 3 3 2 2 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 4 |
Focal Cellular Change | 1 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
Duct, Ectasia | 4 |
Duct, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 |
Hyperplasia, Squamous | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 7| 7| 7| 4| 6| 7| 4| 6| 5| 6| 7| 0|
DAY ON TEST | 3| 3| 5| 0| 1| 3| 1| 3| 8| 5| 5| 4| 3| 3| 3| 3| 5| 3| 3| 5| 7| 8| 9| 0| 0|
| 5| 5| 7| 6| 0| 5| 7| 5| 1| 7| 8| 1| 5| 5| 5| 5| 7| 5| 5| 7| 8| 1| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + M + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 1 1 1 1 1 2 1 1 |
Hyperplasia, Atypical | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia | 3 |
Hypertrophy | 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M M + + + M M + M + M M M M + M M + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 4 1 2 3 2 1 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 1 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M M M + M M + M + + M + + |
Atrophy | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 4 4 4 |
Amyloid Deposition | 2 |
Angiectasis | 4 3 |
Atrophy | 2 2 1 1 2 2 1 |
Cyst | X X X X X |
Mineralization | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 7| 7| 7| 4| 6| 7| 4| 6| 5| 6| 7| 0|
DAY ON TEST | 3| 3| 5| 0| 1| 3| 1| 3| 8| 5| 5| 4| 3| 3| 3| 3| 5| 3| 3| 5| 7| 8| 9| 0| 0|
| 5| 5| 7| 6| 0| 5| 7| 5| 1| 7| 8| 1| 5| 5| 5| 5| 7| 5| 5| 7| 8| 1| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Amyloid Deposition | 1 |
Hyperplasia, Cystic | 3 3 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 3 4 2 2 3 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Neutrophil | 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M M + M + + + + M M + + M + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia | 2 2 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + + M + + + + + + M + M + + + M + + M + |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + M + + + + + + + + + + + + + |
Angiectasis | 2 |
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Histiocytic | |
Hyperplasia | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + M + + + + + + + + + M + M + + M + + + + |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia | 2 2 3 2 3 2 |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 3 |
Hematopoietic Cell Proliferation | 2 1 4 2 1 2 1 4 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 2 2 1 1 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + M + + + + + + |
Atrophy | 2 3 3 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + |
Fibrous Osteodystrophy | 2 2 2 2 2 1 1 1 2 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 7| 7| 7| 4| 6| 7| 4| 6| 5| 6| 7| 0|
DAY ON TEST | 3| 3| 5| 0| 1| 3| 1| 3| 8| 5| 5| 4| 3| 3| 3| 3| 5| 3| 3| 5| 7| 8| 9| 0| 0|
| 5| 5| 7| 6| 0| 5| 7| 5| 1| 7| 8| 1| 5| 5| 5| 5| 7| 5| 5| 7| 8| 1| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Inflammation | |
Mineralization | 1 1 2 2 1 2 1 1 1 1 1 1 1 1 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 1 1 |
Inflammation, Acute | 2 |
Inflammation, Suppurative | 1 |
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Artery, Mediastinum, Inflammation | |
Mediastinum, Hemorrhage | |
Mediastinum, Inflammation, | |
Suppurative | 4 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Atrophy | 1 1 2 1 |
Olfactory Epithelium, Metaplasia | 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | 4 |
Hyperplasia, Atypical | |
Inflammation, Suppurative | 3 |
Nephropathy | 1 1 2 1 1 1 1 1 2 1 |
Arteriole, Inflammation, Chronic | |
Cortex, Cyst | |
Cortex, Pigmentation, Hemosiderin | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 7| 7| 7| 4| 6| 7| 4| 6| 5| 6| 7| 0|
DAY ON TEST | 3| 3| 5| 0| 1| 3| 1| 3| 8| 5| 5| 4| 3| 3| 3| 3| 5| 3| 3| 5| 7| 8| 9| 0| 0|
| 5| 5| 7| 6| 0| 5| 7| 5| 1| 7| 8| 1| 5| 5| 5| 5| 7| 5| 5| 7| 8| 1| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Ulcer | 3 |
Arteriole, Inflammation | 3 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 2| 5| 3| 3| 3| 3| 2| 3| 3| 0| | |
| 3| 7| 5| 5| 5| 5| 6| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | A + + M + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + M | 56 |
Hemorrhage | | 1 1.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + + + + + | 55 |
Hemorrhage | | 1 2.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + | 54 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Basophilic Focus | | 2 |
Degeneration, Cystic | | 1 2.0|
Eosinophilic Focus | | 5 |
Focal Cellular Change | | 1 |
Hematopoietic Cell Proliferation | | 8 2.1|
Hyperplasia, Lymphoid | | 1 2.0|
Infarct | | 1 4.0|
Mixed Cell Focus | | 4 |
Necrosis | 3 1 | 5 1.4|
Bile Duct, Cyst | | 1 |
Bile Duct, Degeneration | | 1 2.0|
Centrilobular, Necrosis | | 1 3.0|
Serosa, Inflammation, Suppurative | | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | | 10 |
Angiectasis | | 1 2.0|
Inflammation, Chronic | | 2 2.5|
Fat, Necrosis | | 7 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy | | 2 2.5|
Focal Cellular Change | | 2 1.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | 1 | 3 2.0|
Duct, Ectasia | | 3 3.7|
Duct, Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 2| 5| 3| 3| 3| 3| 2| 3| 3| 0| | |
| 3| 7| 5| 5| 5| 5| 6| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Angiectasis | | 1 1.0|
Hyperplasia, Squamous | 4 | 2 3.5|
Inflammation, Suppurative | 1 | 1 1.0|
Ulcer | 1 | 1 1.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + M + M + + + + | 52 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy | 1 1 1 | 16 1.1|
Hyperplasia, Atypical | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia | 3 | 4 2.3|
Hypertrophy | 1 | 3 1.0|
Capsule, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + M M | 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + | 58 |
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia | 1 1 4 2 | 19 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 1 1 | 12 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 2| 5| 3| 3| 3| 3| 2| 3| 3| 0| | |
| 3| 7| 5| 5| 5| 5| 6| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M M + M + + M + M | 40 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + M + + + + + + | 58 |
Abscess | | 4 4.0|
Amyloid Deposition | | 1 2.0|
Angiectasis | | 3 2.7|
Atrophy | 3 | 17 2.0|
Cyst | X X X X X | 19 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 1.0|
Hyperplasia, Cystic | 2 2 3 2 2 2 2 2 2 2 | 57 2.4|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Hyperplasia, Neutrophil | | 6 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + | 7 |
Iliac, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M M + + + | 48 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia | 2 1 3 | 11 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M + + + + | 42 |
Hyperplasia | | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M | 54 |
Angiectasis | | 1 2.0|
Congestion | | 2 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Histiocytic | | 1 4.0|
Hyperplasia | 2 | 3 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + M + | 43 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia | | 6 2.3|
Inflammation, Suppurative | | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 4 | 12 2.3|
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 2| 5| 3| 3| 3| 3| 2| 3| 3| 0| | |
| 3| 7| 5| 5| 5| 5| 6| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 1 | 14 1.9|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + M | 54 |
Atrophy | | 5 2.6|
Hyperplasia, Lymphoid | 3 | 6 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Fibrous Osteodystrophy | 2 3 1 2 1 | 27 1.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 1.0|
Inflammation | 2 | 1 2.0|
Mineralization | 1 1 1 | 28 1.2|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Hemorrhage | | 4 1.5|
Inflammation, Acute | | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 3 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Artery, Mediastinum, Inflammation | 4 | 1 4.0|
Mediastinum, Hemorrhage | | 1 3.0|
Mediastinum, Inflammation, | | |
Suppurative | | 1 4.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 2| 5| 3| 3| 3| 3| 2| 3| 3| 0| | |
| 3| 7| 5| 5| 5| 5| 6| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Inflammation, Suppurative | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 1.0|
Olfactory Epithelium, Atrophy | | 5 1.4|
Olfactory Epithelium, Metaplasia | | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 4.0|
Hyperplasia, Atypical | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Nephropathy | 1 1 1 1 | 24 1.1|
Arteriole, Inflammation, Chronic | | 1 2.0|
Cortex, Cyst | 3 | 1 3.0|
Cortex, Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + M + + + + + + + + | 57 |
Inflammation, Chronic | | 1 2.0|
Ulcer | | 1 3.0|
Arteriole, Inflammation | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 4| 6| 4| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 8| 5| 7| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| 3|
| 7| 6| 7| 9| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 8| 7| 6| 6| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
50 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + M + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Cyst | X |
Cytomegaly | 4 |
Degeneration, Fatty | |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Mononuclear | |
Cell | |
Karyomegaly | 3 |
Mixed Cell Focus | X X |
Necrosis | 1 |
Pigmentation, Hemosiderin | 2 |
Regeneration | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Fat, Necrosis | 2 3 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Atrophy | 3 |
Focal Cellular Change | |
Hyperplasia | 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Hyperplasia, Squamous | 2 2 4 4 2|
Inflammation, Suppurative | 1 3 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
Inflammation, Suppurative | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 4| 6| 4| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 8| 5| 7| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| 3|
| 7| 6| 7| 9| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 8| 7| 6| 6| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
50 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + M + + + + + + + + M M + + M + + +|
Mineralization | |
Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 1 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + I + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + M + M M M + M + + M M + M + + + + + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 1 1 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M M M + + + M + + M + M M + M + M M M + + + M +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Angiectasis | 2 |
Atrophy | 3 1 1 1 1 1 1 2 2 3 2 |
Cyst | X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Cystic | 2 2 3 1 3 2 3 4 3 2 2 3 2 2 2 2 4 2 2 3 3 3|
Myometrium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 4| 6| 4| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 8| 5| 7| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| 3|
| 7| 6| 7| 9| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 8| 7| 6| 6| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
50 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + +|
Iliac, Hemorrhage | |
Iliac, Hyperplasia | 2 |
Renal, Congestion | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + + + + +|
Erythrophagocytosis | |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + M + M + + M + M + + I + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + M + M + + + + + + + + +|
Angiectasis | 2 |
Congestion | |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + M + + + M M + M M M + + + + + + + + + +|
Erythrophagocytosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 4 2 2 2 |
Hyperplasia, Lymphoid | 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Developmental Malformation | |
Hyperplasia, Lymphoid | 2 2 4 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 3 1 1 1 2 3|
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 4| 6| 4| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 8| 5| 7| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| 3|
| 7| 6| 7| 9| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 8| 7| 6| 6| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
50 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus | X |
Hemorrhage | |
Infiltration Cellular, Mononuclear | |
Cell | |
Alveolar Epithelium, Hyperplasia | 2 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
Olfactory Epithelium, Atrophy | 1 1 |
Olfactory Epithelium, Metaplasia | 1 1 |
Olfactory Epithelium, Necrosis | 3 |
Respiratory Epithelium, Necrosis | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 |
Hydronephrosis | 1 |
Infarct | |
Infiltration Cellular, Mononuclear | |
Cell | |
Metaplasia, Osseous | 1 1 |
Nephropathy | 1 1 2 1 1 1 1 1 1 2 1 4 1 1 1 1|
Cortex, Pigmentation, Hemosiderin | |
Glomerulus, Embolus | |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 6| 4| 6| 7| 4| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 4| 5| 2| 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 3| 5| 3| 3| 3| 3|
| 6| 6| 6| 5| 6| 2| 6| 7| 2| 6| 5| 6| 7| 7| 6| 6| 6| 5| 6| 6| 7| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + A + + + + + + + + + I + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M A + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Cyst | |
Cytomegaly | |
Degeneration, Fatty | 2 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 3 |
Infiltration Cellular, Mononuclear | |
Cell | 2 2 |
Karyomegaly | |
Mixed Cell Focus | X |
Necrosis | 1 |
Pigmentation, Hemosiderin | |
Regeneration | 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Atrophy | 4 |
Focal Cellular Change | 1 |
Hyperplasia | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Hyperplasia, Squamous | 1 4 |
Inflammation, Suppurative | 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 6| 4| 6| 7| 4| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 4| 5| 2| 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 3| 5| 3| 3| 3| 3|
| 6| 6| 6| 5| 6| 2| 6| 7| 2| 6| 5| 6| 7| 7| 6| 6| 6| 5| 6| 6| 7| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | M M + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Thrombosis | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Hematopoietic Cell Proliferation | 1 2 |
Hyperplasia | |
Hypertrophy | 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Parathyroid Gland | I + + M + + M M + + M M M + + + M M M M + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 1 2 2 4 1 4 4 |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + M M + M + + + + + + M + + M + + + + +|
__________________________________________________________________________|
Ovary | + + + + + A + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Angiectasis | |
Atrophy | 2 2 1 2 1 |
Cyst | X X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4 |
Hyperplasia, Cystic | 4 2 2 3 2 1 3 2 2 2 2 2 3 4 2 2 3 2 1 3 2 2|
Myometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 6| 4| 6| 7| 4| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 4| 5| 2| 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 3| 5| 3| 3| 3| 3|
| 6| 6| 6| 5| 6| 2| 6| 7| 2| 6| 5| 6| 7| 7| 6| 6| 6| 5| 6| 6| 7| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hemorrhage | |
Iliac, Hyperplasia | |
Renal, Congestion | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | 2 |
Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M I + + + + + + + M M + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + M + + + + + M + + +|
Angiectasis | |
Congestion | 3 |
Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M M + + + M + M + + + + M + + + + M + + +|
Erythrophagocytosis | 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 4 2 2 1 |
Hyperplasia, Lymphoid | 2 2 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Atrophy | 3 |
Developmental Malformation | X |
Hyperplasia, Lymphoid | 2 2 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 2 1 1 2 1 2 |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Mineralization | 1 1 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 6| 4| 6| 7| 4| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 0| 4| 5| 2| 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 3| 5| 3| 3| 3| 3|
| 6| 6| 6| 5| 6| 2| 6| 7| 2| 6| 5| 6| 7| 7| 6| 6| 6| 5| 6| 6| 7| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus | |
Hemorrhage | 1 |
Infiltration Cellular, Mononuclear | |
Cell | 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Atrophy | 1 1 |
Olfactory Epithelium, Metaplasia | 1 |
Olfactory Epithelium, Necrosis | |
Respiratory Epithelium, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hydronephrosis | |
Infarct | 4 |
Infiltration Cellular, Mononuclear | |
Cell | 2 |
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1|
Cortex, Pigmentation, Hemosiderin | 2 |
Glomerulus, Embolus | 2 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + I + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 3| 7| 6| 4| | |
DAY ON TEST | 3| 3| 3| 6| 1| 5| 6| 1| 2| 5| | |
| 6| 6| 6| 4| 7| 7| 9| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + A + + + | 55 |
Inflammation, Suppurative | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + A + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + A + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X | 3 |
Clear Cell Focus | | 1 |
Cyst | | 1 |
Cytomegaly | | 1 4.0|
Degeneration, Fatty | 3 | 2 2.5|
Eosinophilic Focus | | 3 |
Hematopoietic Cell Proliferation | | 2 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 2 2.0|
Karyomegaly | | 1 3.0|
Mixed Cell Focus | X | 4 |
Necrosis | 1 2 | 4 1.3|
Pigmentation, Hemosiderin | | 1 2.0|
Regeneration | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 16 |
Fat, Necrosis | 2 | 9 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + | 59 |
Amyloid Deposition | | 1 3.0|
Atrophy | | 2 3.5|
Focal Cellular Change | | 1 1.0|
Hyperplasia | | 1 1.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Diverticulum | | 1 2.0|
Hyperplasia, Squamous | 3 | 8 2.8|
Inflammation, Suppurative | | 3 1.7|
Ulcer | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 3| 7| 6| 4| | |
DAY ON TEST | 3| 3| 3| 6| 1| 5| 6| 1| 2| 5| | |
| 6| 6| 6| 4| 7| 7| 9| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + | 58 |
Hyperplasia | | 2 1.5|
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + M + + + | 53 |
Mineralization | 2 | 1 2.0|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 1 1 | 19 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + A + + + | 59 |
Cyst | | 3 |
Hematopoietic Cell Proliferation | | 2 1.5|
Hyperplasia | | 2 1.5|
Hypertrophy | | 4 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + A + + + | 58 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + | 59 |
Hyperplasia | | 5 1.2|
__________________________________________________________________________|____________|
Parathyroid Gland | I M + + + + M + + M | 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + A + + + | 59 |
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia | 2 1 | 16 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + A + + + | 58 |
Inflammation, Suppurative | | 1 1.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 6 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + | 41 |
__________________________________________________________________________|____________|
Ovary | + + + + + + A + M + | 57 |
Amyloid Deposition | | 1 2.0|
Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 3| 7| 6| 4| | |
DAY ON TEST | 3| 3| 3| 6| 1| 5| 6| 1| 2| 5| | |
| 6| 6| 6| 4| 7| 7| 9| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | 2 2 1 | 19 1.6|
Cyst | X X X | 18 |
__________________________________________________________________________|____________|
Uterus | + + + + + + A + + + | 59 |
Dilatation | | 2 4.0|
Hyperplasia, Cystic | 4 3 4 2 2 3 4 3 1 | 53 2.5|
Myometrium, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + + + | 59 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 9 |
Iliac, Hemorrhage | 4 | 1 4.0|
Iliac, Hyperplasia | | 1 2.0|
Renal, Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + A M I + | 54 |
Erythrophagocytosis | | 1 2.0|
Hyperplasia | | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + M + M + + | 45 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + A + + + | 53 |
Angiectasis | | 1 2.0|
Congestion | | 1 3.0|
Hyperplasia | | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + M A + M + | 43 |
Erythrophagocytosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + A + + + | 59 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 3 | 12 2.4|
Hyperplasia, Lymphoid | 1 2 | 15 1.9|
__________________________________________________________________________|____________|
Thymus | + + + + + + A + + + | 58 |
Angiectasis | | 1 2.0|
Atrophy | 2 | 2 2.5|
Developmental Malformation | | 1 |
Hyperplasia, Lymphoid | | 5 2.4|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 3| 7| 6| 4| | |
DAY ON TEST | 3| 3| 3| 6| 1| 5| 6| 1| 2| 5| | |
| 6| 6| 6| 4| 7| 7| 9| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | 1 2 | 18 1.6|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 1.0|
Mineralization | 1 1 1 1 | 31 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + A + + + | 59 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Embolus | | 1 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 4 1.8|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
Olfactory Epithelium, Atrophy | | 4 1.0|
Olfactory Epithelium, Metaplasia | | 3 1.0|
Olfactory Epithelium, Necrosis | | 1 3.0|
Respiratory Epithelium, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + A + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + A + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 3| 7| 6| 4| | |
DAY ON TEST | 3| 3| 3| 6| 1| 5| 6| 1| 2| 5| | |
| 6| 6| 6| 4| 7| 7| 9| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Amyloid Deposition | | 2 2.5|
Hydronephrosis | | 1 1.0|
Infarct | | 1 4.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 2.0|
Metaplasia, Osseous | 1 | 3 1.0|
Nephropathy | 1 1 1 2 | 32 1.2|
Cortex, Pigmentation, Hemosiderin | | 1 2.0|
Glomerulus, Embolus | | 1 2.0|
Renal Tubule, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6|
DAY ON TEST | 0| 3| 8| 3| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 6| 3| 3| 5| 0| 3| 2| 5| 5| 3| 5|
| 6| 4| 3| 6| 2| 6| 6| 6| 7| 6| 0| 6| 6| 6| 3| 6| 6| 7| 4| 6| 7| 7| 7| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A I + + A + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A I + + A + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + A + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | |
Degeneration, Fatty | 2 |
Eosinophilic Focus | |
Focal Cellular Change | 1 X |
Hematopoietic Cell Proliferation | |
Mitotic Alteration | 1 |
Mixed Cell Focus | |
Necrosis | 2 2 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Focal Cellular Change | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 4 4 3 |
Inflammation, Suppurative | 2 2 |
Necrosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + M + + + + + + + + + + + + M + + + + M|
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 |
Hyperplasia, Atypical | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6|
DAY ON TEST | 0| 3| 8| 3| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 6| 3| 3| 5| 0| 3| 2| 5| 5| 3| 5|
| 6| 4| 3| 6| 2| 6| 6| 6| 7| 6| 0| 6| 6| 6| 3| 6| 6| 7| 4| 6| 7| 7| 7| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hematopoietic Cell Proliferation | |
Hypertrophy | 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M M M M M + + M + M M + M + + + + M + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 1 1 4 2 2 1 1 2 2 3 3|
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + M + + + + M M + + + + M + +|
__________________________________________________________________________|
Ovary | + + + + M + + I + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 2 3 2 2 2 2 2 2 |
Cyst | X X 1 X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Dilatation | |
Hyperplasia, Cystic | 2 1 3 4 2 2 4 4 2 2 2 3 4 2 3 3 2 2 3 1 3 1 3 2|
Inflammation, Suppurative | |
Thrombosis | |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 2 |
__________________________________________________________________________|
Lymph Node | + + +|
Axillary, Hyperplasia | |
Iliac, Hyperplasia | |
Popliteal, Hyperplasia | 2 |
Renal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + M + + + M + + + + M M + + + + + + +|
Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6|
DAY ON TEST | 0| 3| 8| 3| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 6| 3| 3| 5| 0| 3| 2| 5| 5| 3| 5|
| 6| 4| 3| 6| 2| 6| 6| 6| 7| 6| 0| 6| 6| 6| 3| 6| 6| 7| 4| 6| 7| 7| 7| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + M + + + + + + + + + M M + + + + +|
Hyperplasia | 2 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + I + + + I + + + +|
Amyloid Deposition | |
Angiectasis | |
Hemorrhage | |
Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + + M + + + + M + + + M M + M M M + M|
Hyperplasia | 2 2 2 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hematopoietic Cell Proliferation | 2 1 2 2 2 3 |
Hyperplasia, Lymphoid | 2 2 2 2 3 2 2 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + M + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 1 |
Hyperplasia, Lymphoid | 2 2 4 2 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Hyperplasia | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 2 1 1 |
Fracture | |
Inflammation, Chronic | |
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
Inflammation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 1 1 1 1 1 2 1 1 1|
Pigmentation, Hemosiderin | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6|
DAY ON TEST | 0| 3| 8| 3| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 6| 3| 3| 5| 0| 3| 2| 5| 5| 3| 5|
| 6| 4| 3| 6| 2| 6| 6| 6| 7| 6| 0| 6| 6| 6| 3| 6| 6| 7| 4| 6| 7| 7| 7| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 |
Arteriole, Inflammation | 3 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Atrophy | 1 1 2|
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1|
Respiratory Epithelium, Necrosis | 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + M + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 6| 5| 7| 4| 6| 7| 7| 4| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 0| 7| 3| 6| 5| 3| 5| 3| 3| 3| 5| 7| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3|
| 6| 6| 7| 8| 0| 6| 5| 2| 6| 7| 5| 6| 6| 7| 1| 6| 6| 3| 6| 6| 7| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + A M + + + M + A + + + + + + +|
Hyperplasia | 1 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + M + + + + + + A + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + M + + A + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Clear Cell Focus | X |
Degeneration, Fatty | |
Eosinophilic Focus | X X |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 2 |
Mitotic Alteration | 2 |
Mixed Cell Focus | |
Necrosis | 1 1 4 1 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Focal Cellular Change | 1 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 2 1 1 1 |
Inflammation, Suppurative | 2 |
Necrosis | 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + M + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1|
Hyperplasia, Atypical | 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 6| 5| 7| 4| 6| 7| 7| 4| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 0| 7| 3| 6| 5| 3| 5| 3| 3| 3| 5| 7| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3|
| 6| 6| 7| 8| 0| 6| 5| 2| 6| 7| 5| 6| 6| 7| 1| 6| 6| 3| 6| 6| 7| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hematopoietic Cell Proliferation | 1 |
Hypertrophy | 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M M M + M + + M M M M M M + + M + M M M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 1 1 1 1 1 3|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + M + M M + M + M + + + + + + M + + M + + M +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Atrophy | 3 1 1 2 1 1 1 2 |
Cyst | X X X X X X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Dilatation | |
Hyperplasia, Cystic | 2 1 2 4 1 2 3 4 4 3 2 2 2 4 3 3 3 2 3 3 2 2|
Inflammation, Suppurative | 3 |
Thrombosis | |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 4 |
__________________________________________________________________________|
Lymph Node | + + +|
Axillary, Hyperplasia | 1 |
Iliac, Hyperplasia | |
Popliteal, Hyperplasia | |
Renal, Angiectasis | 4|
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + + + + M + + + + + + M + + + + +|
Hyperplasia | 2 4 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 6| 5| 7| 4| 6| 7| 7| 4| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 0| 7| 3| 6| 5| 3| 5| 3| 3| 3| 5| 7| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3|
| 6| 6| 7| 8| 0| 6| 5| 2| 6| 7| 5| 6| 6| 7| 1| 6| 6| 3| 6| 6| 7| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + M M + + + + + + + + + + + + + M|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Angiectasis | |
Hemorrhage | 3 |
Hyperplasia | 2 3 3 1 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + M + + M + M + + + + + M + M + +|
Hyperplasia | 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Hematopoietic Cell Proliferation | 2 1 3 3 2 1 |
Hyperplasia, Lymphoid | 3 2 2 3 2 1 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2|
Epithelial Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Hyperplasia | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 1 2 2 2 1 1 |
Fracture | X |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | 2 |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 2 1 1 2 1 1|
Pigmentation, Hemosiderin | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 6| 5| 7| 4| 6| 7| 7| 4| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 0| 7| 3| 6| 5| 3| 5| 3| 3| 3| 5| 7| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3|
| 6| 6| 7| 8| 0| 6| 5| 2| 6| 7| 5| 6| 6| 7| 1| 6| 6| 3| 6| 6| 7| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Arteriole, Inflammation | |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1|
Olfactory Epithelium, Atrophy | 1 1 |
Olfactory Epithelium, Metaplasia | 1 1 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Respiratory Epithelium, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + A + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 7| 7| 4| 6| 7| | |
DAY ON TEST | 3| 7| 6| 1| 5| 3| 3| 5| 6| 0| | |
| 6| 0| 8| 9| 7| 6| 6| 7| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + I + + + + + + | 51 |
Hyperplasia | | 1 1.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 54 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
Amyloid Deposition | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Clear Cell Focus | | 1 |
Degeneration, Fatty | | 1 2.0|
Eosinophilic Focus | X | 3 |
Focal Cellular Change | | 2 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Mitotic Alteration | | 2 1.5|
Mixed Cell Focus | X | 1 |
Necrosis | | 8 1.6|
Centrilobular, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Fat, Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 1 1.0|
Focal Cellular Change | | 2 1.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia, Squamous | 4 | 9 2.3|
Inflammation, Suppurative | 2 | 4 2.0|
Necrosis | | 1 1.0|
Ulcer | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + M + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 7| 7| 4| 6| 7| | |
DAY ON TEST | 3| 7| 6| 1| 5| 3| 3| 5| 6| 0| | |
| 6| 0| 8| 9| 7| 6| 6| 7| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + M + + + + + + + + | 59 |
Angiectasis | 1 | 1 1.0|
Cardiomyopathy | 1 1 1 | 23 1.0|
Hyperplasia, Atypical | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hypertrophy | | 7 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + M + + | 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 3 1 1 2 | 24 1.8|
Pars Intermedia, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia | 1 | 9 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Angiectasis | | 2 1.5|
Atrophy | 2 3 2 3 | 20 2.0|
Cyst | X X X X X | 18 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Dilatation | 4 | 1 4.0|
Hyperplasia, Cystic | 4 1 3 3 1 3 2 2 3 | 55 2.5|
Inflammation, Suppurative | 2 | 2 2.5|
Thrombosis | 4 | 1 4.0|
Artery, Inflammation, Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 7| 7| 4| 6| 7| | |
DAY ON TEST | 3| 7| 6| 1| 5| 3| 3| 5| 6| 0| | |
| 6| 0| 8| 9| 7| 6| 6| 7| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia, Neutrophil | 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 9 |
Axillary, Hyperplasia | | 1 1.0|
Iliac, Hyperplasia | 3 | 1 3.0|
Popliteal, Hyperplasia | | 1 2.0|
Renal, Angiectasis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + M | 51 |
Hyperplasia | 2 1 | 7 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 52 |
Hyperplasia | | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Amyloid Deposition | | 1 3.0|
Angiectasis | 1 2 | 2 1.5|
Hemorrhage | | 1 3.0|
Hyperplasia | 2 | 9 1.9|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + M + | 44 |
Hyperplasia | 2 3 | 10 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 4.0|
Hematopoietic Cell Proliferation | 2 1 2 | 15 1.9|
Hyperplasia, Lymphoid | | 13 2.2|
Capsule, Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 56 |
Angiectasis | 2 | 2 2.0|
Atrophy | | 1 1.0|
Hyperplasia, Lymphoid | 1 2 | 12 2.1|
Epithelial Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Sebaceous Gland, Hyperplasia | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 7| 7| 4| 6| 7| | |
DAY ON TEST | 3| 7| 6| 1| 5| 3| 3| 5| 6| 0| | |
| 6| 0| 8| 9| 7| 6| 6| 7| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | 1 1 1 | 16 1.5|
Fracture | | 1 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemorrhage | | 1 2.0|
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization | 2 1 1 | 28 1.2|
Pigmentation, Hemosiderin | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | 2 | 5 1.4|
Alveolar Epithelium, Hyperplasia | 2 1 | 2 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.5|
Arteriole, Inflammation | 2 | 2 2.5|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 1 | 2 1.0|
Olfactory Epithelium, Atrophy | | 5 1.2|
Olfactory Epithelium, Metaplasia | | 2 1.0|
Respiratory Epithelium, Hyperplasia | | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
Respiratory Epithelium, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
Metaplasia, Squamous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 7| 7| 4| 6| 7| | |
DAY ON TEST | 3| 7| 6| 1| 5| 3| 3| 5| 6| 0| | |
| 6| 0| 8| 9| 7| 6| 6| 7| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 1 2 2 1 1 | 27 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 7| 4| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 2| 7| 4| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 1| 3| 5| 5| 3| 5| 3| 3| 3| 3| 5| 4| 5| 3| 3| 9| 9| 3| 5| 3| 1| 3| 7| 3|
| 5| 0| 5| 7| 7| 5| 7| 5| 5| 5| 5| 7| 4| 0| 5| 5| 1| 4| 5| 7| 5| 0| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 1 |
Infarct | |
Karyomegaly | |
Mitotic Alteration | |
Necrosis | 2 |
Bile Duct, Cyst | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 2 |
Hyperplasia, Squamous | 2 4 3 3 4 3 2 4 |
Inflammation, Suppurative | 3 2 2 |
Ulcer | 2 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | M + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hypertrophy | 1 |
Capsule, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 7| 4| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 2| 7| 4| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 1| 3| 5| 5| 3| 5| 3| 3| 3| 3| 5| 4| 5| 3| 3| 9| 9| 3| 5| 3| 1| 3| 7| 3|
| 5| 0| 5| 7| 7| 5| 7| 5| 5| 5| 5| 7| 4| 0| 5| 5| 1| 4| 5| 7| 5| 0| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + M + M + + + + M + + + + + M + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 2 1 1 4 2 2 1 4|
Pars Distalis, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + M + + + + + + + + + M + + + M + + + + M M|
__________________________________________________________________________|
Ovary | + + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 2 3 2|
Cyst | X X X X X X |
Germinal Epithelium, Hyperplasia | 3 |
Interstitium, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hyperplasia, Cystic | 3 3 2 2 1 4 2 2 3 4 2 3 2 3 1 1 2 1 1 2 2 2 |
Inflammation, Suppurative | |
Arteriole, Hypertrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | |
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M + + + + + + M M + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + M + M M + + M + M + + M + M + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M M + + M + + + + + + + + + M + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M I + M + M M + + + + + + M + M + + + M + + M +|
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 7| 4| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 2| 7| 4| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 1| 3| 5| 5| 3| 5| 3| 3| 3| 3| 5| 4| 5| 3| 3| 9| 9| 3| 5| 3| 1| 3| 7| 3|
| 5| 0| 5| 7| 7| 5| 7| 5| 5| 5| 5| 7| 4| 0| 5| 5| 1| 4| 5| 7| 5| 0| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 1 2 3 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M M + + + + + M + + + + + M + M +|
Angiectasis | |
Atrophy | 1 |
Hyperplasia, Lymphoid | 1 1 1 |
Necrosis | 2 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 2 1 2 2 2 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 2 2 |
Mineralization | 1 1 1 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Acute | 2 |
Thrombosis | 1 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Atrophy | 1 1 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 7| 4| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 2| 7| 4| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 1| 3| 5| 5| 3| 5| 3| 3| 3| 3| 5| 4| 5| 3| 3| 9| 9| 3| 5| 3| 1| 3| 7| 3|
| 5| 0| 5| 7| 7| 5| 7| 5| 5| 5| 5| 7| 4| 0| 5| 5| 1| 4| 5| 7| 5| 0| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Metaplasia | 1 |
Olfactory Epithelium, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +|
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 5| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 4| 7| 5|
DAY ON TEST | 3| 2| 3| 3| 5| 0| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 6| 4| 3| 6|
| 5| 0| 0| 5| 7| 9| 5| 5| 2| 7| 5| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 4| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + A + + + + + + + + + + + + + A + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + I + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 3 2 |
Infarct | 4|
Karyomegaly | 1 |
Mitotic Alteration | 3 |
Necrosis | |
Bile Duct, Cyst | X |
Centrilobular, Necrosis | 2 2 3|
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 2 1 2 1 1 1 1 4 1 3 2 2 3|
Inflammation, Suppurative | |
Ulcer | 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + M + + + + + + + + + M + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 1 1 1 |
Inflammation, Suppurative | 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hypertrophy | 1 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 5| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 4| 7| 5|
DAY ON TEST | 3| 2| 3| 3| 5| 0| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 6| 4| 3| 6|
| 5| 0| 0| 5| 7| 9| 5| 5| 2| 7| 5| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 4| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M M M + + M M + + + M M M + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 4 2 2 4 2 1 |
Pars Distalis, Inflammation, Chronic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M M M + + + + M + + + + + M + + + + + + M M|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | 2 2 2 2 2 2|
Cyst | X X |
Germinal Epithelium, Hyperplasia | |
Interstitium, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Cystic | 2 2 3 1 1 3 2 2 3 2 4 2 3 2 4 3 2 2 2 3 2|
Inflammation, Suppurative | 2 |
Arteriole, Hypertrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | 2 |
Hyperplasia, Neutrophil | 2 3 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + M + + + + M M M M + + + + + + + M|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M M M M + M M + + + M + + + + + + + M + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + M + + + + + + + + + + M + + +|
Hyperplasia | 4 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + + M + + + + + + + + + + + + M M + + + M +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 5| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 4| 7| 5|
DAY ON TEST | 3| 2| 3| 3| 5| 0| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 6| 4| 3| 6|
| 5| 0| 0| 5| 7| 9| 5| 5| 2| 7| 5| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 4| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 2 4 2 1 |
Hyperplasia, Lymphoid | 4 2 1 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + I + + I|
Angiectasis | 2 |
Atrophy | 2 2 2 |
Hyperplasia, Lymphoid | 2 2 |
Necrosis | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 1 2 1 1 2 1 |
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
Mineralization | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 2 |
Inflammation, Acute | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Atrophy | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 5| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 4| 7| 5|
DAY ON TEST | 3| 2| 3| 3| 5| 0| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 6| 4| 3| 6|
| 5| 0| 0| 5| 7| 9| 5| 5| 2| 7| 5| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 4| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Metaplasia | |
Olfactory Epithelium, Necrosis | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 1 |
Nephropathy | 1 1 1 1 1 2 1 1 1 |
Renal Tubule, Necrosis | 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 2| 3| 3| 6| 5| 3| 3| 1| 3| | |
| 7| 9| 5| 5| 4| 7| 5| 5| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + A + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + | 56 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + M + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + M + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + A + + + + + + + + | 59 |
Eosinophilic Focus | X X | 4 |
Hematopoietic Cell Proliferation | 3 | 4 2.3|
Infarct | | 1 4.0|
Karyomegaly | | 1 1.0|
Mitotic Alteration | | 1 3.0|
Necrosis | 2 | 2 2.0|
Bile Duct, Cyst | | 1 |
Centrilobular, Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Necrosis | | 4 2.3|
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + | 58 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + A + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + | 58 |
Hyperkeratosis | 3 | 5 2.2|
Hyperplasia, Squamous | 1 3 2 2 | 25 2.3|
Inflammation, Suppurative | | 3 2.3|
Ulcer | | 5 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Dysplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + M + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 | 15 1.1|
Inflammation, Suppurative | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 2| 3| 3| 6| 5| 3| 3| 1| 3| | |
| 7| 9| 5| 5| 4| 7| 5| 5| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + A + + + + + + + + | 59 |
Cyst | | 1 |
Hypertrophy | | 3 1.0|
Capsule, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + A + + + + + + + + | 58 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + | 57 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M + + M M + M | 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + A + + + + + + + + | 58 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 1 1 2 1 | 21 1.9|
Pars Distalis, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + | 59 |
Inflammation | | 1 2.0|
Follicle, Cyst | X | 3 |
Follicular Cell, Hyperplasia | 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M A + M + + + + + + | 44 |
__________________________________________________________________________|____________|
Ovary | + A + + + + + + + + | 57 |
Atrophy | 3 | 13 2.2|
Cyst | X X X X X | 13 |
Germinal Epithelium, Hyperplasia | | 1 3.0|
Interstitium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + A + + + + + + + + | 59 |
Angiectasis | | 2 1.5|
Hyperplasia, Cystic | 1 1 4 2 3 4 2 3 4 | 52 2.3|
Inflammation, Suppurative | | 1 2.0|
Arteriole, Hypertrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + | 59 |
Hyperplasia, Megakaryocyte | | 1 2.0|
Hyperplasia, Neutrophil | 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 2| 3| 3| 6| 5| 3| 3| 1| 3| | |
| 7| 9| 5| 5| 4| 7| 5| 5| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + + + + M + | 46 |
Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + | 41 |
Hyperplasia | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + M + + + + + + | 51 |
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M A + + M + + + M + | 41 |
Hyperplasia | 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + | 58 |
Amyloid Deposition | | 1 2.0|
Hematopoietic Cell Proliferation | 3 1 | 11 2.1|
Hyperplasia, Lymphoid | 2 | 5 2.2|
__________________________________________________________________________|____________|
Thymus | + A + + + + + + + + | 51 |
Angiectasis | | 1 2.0|
Atrophy | 3 | 5 2.0|
Hyperplasia, Lymphoid | 2 2 2 | 8 1.6|
Necrosis | | 1 2.0|
Epithelial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M A + + + + + + + + | 57 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + A + + + + + + + + | 59 |
Inflammation, Suppurative | | 2 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | 1 2 2 2 | 19 1.7|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + A + + + + + + + + | 59 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 1 | 3 1.7|
Mineralization | 1 1 1 | 20 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 2| 3| 3| 6| 5| 3| 3| 1| 3| | |
| 7| 9| 5| 5| 4| 7| 5| 5| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + A + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lung | + A + + + + + + + + | 59 |
Hemorrhage | 1 | 4 2.5|
Inflammation, Acute | | 1 2.0|
Thrombosis | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + A + + + + + + + + | 59 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Olfactory Epithelium, Atrophy | | 2 1.0|
Olfactory Epithelium, Metaplasia | | 1 1.0|
Olfactory Epithelium, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + A + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + A + + + + + + + + | 58 |
Metaplasia, Osseous | | 3 1.0|
Nephropathy | 1 1 | 25 1.0|
Renal Tubule, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + M + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 4| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6| 6|
DAY ON TEST | 9| 3| 5| 3| 3| 5| 1| 3| 5| 4| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 6| 3| 5| 2| 7|
| 8| 3| 6| 3| 3| 6| 4| 3| 6| 6| 3| 3| 3| 3| 3| 3| 8| 6| 3| 3| 3| 3| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + A + + + M + + + A|
Degeneration | |
Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + M|
Necrosis | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A M + + A + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + M + + + A + + + A|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + + + + + + + + + M + + + A + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X |
Cytomegaly | |
Degeneration, Fatty | 1 2 |
Eosinophilic Focus | X |
Focal Cellular Change | 1 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3 |
Infarct | 4 |
Karyomegaly | 1 |
Mitotic Alteration | |
Mixed Cell Focus | X |
Necrosis | 3 2 |
Bile Duct, Degeneration | 3 |
Bile Duct, Hyperplasia | 3 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +|
Atrophy | |
Focal Cellular Change | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 2 |
Inflammation, Suppurative | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Erosion | 1 |
Inflammation, Suppurative | |
Pigmentation, Hemosiderin | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 4| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6| 6|
DAY ON TEST | 9| 3| 5| 3| 3| 5| 1| 3| 5| 4| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 6| 3| 5| 2| 7|
| 8| 3| 6| 3| 3| 6| 4| 3| 6| 6| 3| 3| 3| 3| 3| 3| 8| 6| 3| 3| 3| 3| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 4 |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Necrosis | 2 |
Arteriole, Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | |
Hypertrophy | 2 1 1 1 2 1 1 1 1 2 1 1 4 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + M + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M M + + + + + + M M + + M M + + M|
Hyperplasia | 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Follicular Cell, Hyperplasia | 4 1 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Atrophy | |
Ectasia | 4 3 |
Inflammation, Chronic Active | 3 3 4 2 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + M + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 4| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6| 6|
DAY ON TEST | 9| 3| 5| 3| 3| 5| 1| 3| 5| 4| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 6| 3| 5| 2| 7|
| 8| 3| 6| 3| 3| 6| 4| 3| 6| 6| 3| 3| 3| 3| 3| 3| 8| 6| 3| 3| 3| 3| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + + + + +|
Angiectasis | 4 |
Fibrosis | |
Hyperplasia, Neutrophil | |
Thrombosis | |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + M + + + M + + + + + + M + + + M + M + M|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + M + + + M M + + M|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + M + + + + + A + + + + + + + +|
Angiectasis | 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + M M + + + M + + M M + + + + + M +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +|
Amyloid Deposition | 1 |
Hematopoietic Cell Proliferation | 2 3 1 1 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + A + + + + + M M +|
Atrophy | 2 1 |
Hyperplasia, Lymphoid | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Pinna, Granuloma | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 1 1 1 1 1 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 4| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6| 6|
DAY ON TEST | 9| 3| 5| 3| 3| 5| 1| 3| 5| 4| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 6| 3| 5| 2| 7|
| 8| 3| 6| 3| 3| 6| 4| 3| 6| 6| 3| 3| 3| 3| 3| 3| 8| 6| 3| 3| 3| 3| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 1 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 |
Inflammation, Suppurative | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Atrophy | 1 1 2 |
Olfactory Epithelium, Metaplasia | 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +|
Amyloid Deposition | 4 |
Hydronephrosis | |
Hyperplasia, Cystic | 1 |
Inflammation, Suppurative | |
Nephropathy | 1 1 1 1 1 2 1 2 2 1 1 1 1 1 1 |
Arteriole, Inflammation, Chronic | 2 |
Cortex, Cyst | 1 1 |
Renal Tubule, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 5| 7| 7| 5| 4|
DAY ON TEST | 1| 3| 9| 5| 3| 5| 3| 3| 3| 3| 2| 3| 5| 3| 7| 3| 5| 5| 3| 3| 4| 3| 3| 9| 5|
| 6| 7| 5| 6| 3| 6| 3| 3| 3| 3| 9| 3| 0| 3| 8| 3| 6| 6| 3| 3| 8| 3| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + M + + + + + + + +|
Degeneration | 1 |
Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + M + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + M + + +|
Peyer's Patch, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X |
Cytomegaly | |
Degeneration, Fatty | 4 |
Eosinophilic Focus | X X X |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | |
Infarct | |
Karyomegaly | 1 1 |
Mitotic Alteration | 2 |
Mixed Cell Focus | |
Necrosis | 2 |
Bile Duct, Degeneration | |
Bile Duct, Hyperplasia | |
Centrilobular, Necrosis | 4 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Focal Cellular Change | 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Hyperplasia, Squamous | 3 2 |
Inflammation, Suppurative | 2 |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Suppurative | |
Pigmentation, Hemosiderin | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 5| 7| 7| 5| 4|
DAY ON TEST | 1| 3| 9| 5| 3| 5| 3| 3| 3| 3| 2| 3| 5| 3| 7| 3| 5| 5| 3| 3| 4| 3| 3| 9| 5|
| 6| 7| 5| 6| 3| 6| 3| 3| 3| 3| 9| 3| 0| 3| 8| 3| 6| 6| 3| 3| 8| 3| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + |
Dysplasia | |
Inflammation | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Necrosis | |
Arteriole, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 4 1 2 2 |
Hypertrophy | 1 1 2 2 2 2 1 1 2 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + + + + + + + + + + M + + M + + M +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 3 4 |
Inflammation, Chronic Active | 1 4 1 3 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + + + M + + + M|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 5| 7| 7| 5| 4|
DAY ON TEST | 1| 3| 9| 5| 3| 5| 3| 3| 3| 3| 2| 3| 5| 3| 7| 3| 5| 5| 3| 3| 4| 3| 3| 9| 5|
| 6| 7| 5| 6| 3| 6| 3| 3| 3| 3| 9| 3| 0| 3| 8| 3| 6| 6| 3| 3| 8| 3| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | 1 |
Hyperplasia, Neutrophil | 4 2 3 2 4 |
Thrombosis | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + M + + M M + + M + M + M M + + + + + + M|
Hyperplasia | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + M M + M + + + + + M + + + + M M + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 3 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M M + + + + + M M + + M + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hematopoietic Cell Proliferation | 3 2 1 3 3 |
Hyperplasia, Lymphoid | 1 3 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + M + + + + + + + +|
Atrophy | 1 1 |
Hyperplasia, Lymphoid | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Pinna, Granuloma | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 3 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 2 2 1 1 1 1 1|
Thrombosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 5| 7| 7| 5| 4|
DAY ON TEST | 1| 3| 9| 5| 3| 5| 3| 3| 3| 3| 2| 3| 5| 3| 7| 3| 5| 5| 3| 3| 4| 3| 3| 9| 5|
| 6| 7| 5| 6| 3| 6| 3| 3| 3| 3| 9| 3| 0| 3| 8| 3| 6| 6| 3| 3| 8| 3| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Inflammation, Suppurative | 4 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
Olfactory Epithelium, Atrophy | 4 |
Olfactory Epithelium, Metaplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hydronephrosis | 1 |
Hyperplasia, Cystic | 1 |
Inflammation, Suppurative | 2 |
Nephropathy | 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 |
Arteriole, Inflammation, Chronic | |
Cortex, Cyst | X |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 3| 1| 3| 3| 3| 6| 3| 3| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 54 |
Degeneration | 4 | 2 2.5|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 55 |
Peyer's Patch, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 1 |
Clear Cell Focus | | 4 |
Cytomegaly | 3 | 1 3.0|
Degeneration, Fatty | 1 1 | 5 1.8|
Eosinophilic Focus | X | 5 |
Focal Cellular Change | | 1 1.0|
Hematopoietic Cell Proliferation | | 2 1.5|
Hemorrhage | | 1 3.0|
Infarct | 4 | 2 4.0|
Karyomegaly | 3 | 4 1.5|
Mitotic Alteration | | 1 2.0|
Mixed Cell Focus | X | 2 |
Necrosis | 2 2 | 5 2.2|
Bile Duct, Degeneration | | 1 3.0|
Bile Duct, Hyperplasia | | 1 3.0|
Centrilobular, Necrosis | 2 | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy | | 1 2.0|
Focal Cellular Change | 1 | 3 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Hyperkeratosis | | 1 1.0|
Hyperplasia, Squamous | | 3 2.3|
Inflammation, Suppurative | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 3| 1| 3| 3| 3| 6| 3| 3| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Erosion | 1 | 2 1.0|
Inflammation, Suppurative | 1 | 1 1.0|
Pigmentation, Hemosiderin | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + | 3 |
Dysplasia | 2 | 2 3.0|
Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 1 2 1 1 1 1 | 40 1.1|
Necrosis | | 1 2.0|
Arteriole, Inflammation, Chronic | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + | 58 |
Hyperplasia | | 7 2.3|
Hypertrophy | 1 1 2 1 1 | 28 1.4|
Capsule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 57 |
Hyperplasia | 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + M + | 46 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + I + M + + + | 56 |
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Follicular Cell, Hyperplasia | 2 | 7 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 3| 1| 3| 3| 3| 6| 3| 3| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | 3 | 2 3.0|
Ectasia | | 4 3.5|
Inflammation, Chronic Active | 2 4 | 14 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + M + + + + + | 54 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Atrophy | | 3 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Angiectasis | | 1 4.0|
Fibrosis | 1 | 2 1.0|
Hyperplasia, Neutrophil | | 5 3.0|
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M + + M + | 41 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M M M M + + + | 43 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + | 56 |
Angiectasis | | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Hyperplasia | | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + I + + | 47 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 1.0|
Hematopoietic Cell Proliferation | 3 1 | 12 2.2|
Hyperplasia, Lymphoid | 2 | 4 2.0|
__________________________________________________________________________|____________|
Thymus | + + + I + + + + + + | 53 |
Atrophy | | 4 1.3|
Hyperplasia, Lymphoid | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 3| 1| 3| 3| 3| 6| 3| 3| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 4.0|
Pinna, Granuloma | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 6 2.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization | 1 1 2 1 1 | 23 1.2|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 59 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 5 1.4|
Alveolar Epithelium, Hyperplasia | | 4 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 1 2.0|
Inflammation, Suppurative | | 3 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 4 2.0|
Olfactory Epithelium, Atrophy | | 4 2.0|
Olfactory Epithelium, Metaplasia | | 3 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 4.0|
Hydronephrosis | 1 1 | 3 1.0|
Hyperplasia, Cystic | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| | |
| 3| 1| 3| 3| 3| 6| 3| 3| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 2.0|
Nephropathy | 1 2 1 1 1 1 1 1 | 41 1.1|
Arteriole, Inflammation, Chronic | | 1 2.0|
Cortex, Cyst | 1 1 | 5 1.0|
Renal Tubule, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 4| 7| 4| 6| 7| 7| 4| 4| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 0| 3| 2| 3| 1| 5| 3| 3| 3| 2| 7| 3| 3| 5| 5| 6| 3| 3|
| 4| 4| 6| 4| 4| 4| 4| 2| 4| 3| 4| 4| 6| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + + + + + A + + + + + + + + + +|
Cyst | X |
Degeneration | 2 |
Inflammation, Suppurative | 2 2|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | |
Degeneration, Fatty | 2 2 2 2 2 2 2|
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Infarct | |
Karyomegaly | |
Mitotic Alteration | 3 |
Mixed Cell Focus | X X X |
Necrosis | 1 1 |
Bile Duct, Cyst | 1 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | |
Angiectasis | |
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1|
Focal Cellular Change | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 4 2 |
Inflammation, Suppurative | |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 4| 7| 4| 6| 7| 7| 4| 4| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 0| 3| 2| 3| 1| 5| 3| 3| 3| 2| 7| 3| 3| 5| 5| 6| 3| 3|
| 4| 4| 6| 4| 4| 4| 4| 2| 4| 3| 4| 4| 6| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Cyst | X |
Hyperplasia | 2 4 2 1 |
Hypertrophy | 1 1 1 1 1 2 1 2 2 1 1 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M + + + M + + + + + + M M + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + I + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 3 3 2 |
Inflammation, Chronic Active | 1 2 2 2 3 4 4 |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + M M M + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | 2 |
Hyperplasia, Neutrophil | 2 2 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 4| 7| 4| 6| 7| 7| 4| 4| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 0| 3| 2| 3| 1| 5| 3| 3| 3| 2| 7| 3| 3| 5| 5| 6| 3| 3|
| 4| 4| 6| 4| 4| 4| 4| 2| 4| 3| 4| 4| 6| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | |
Iliac, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + M + + M M + + + + + + + M M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M M M M + + + + M M + M + + M M + + + + M M +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia | 2 3 2|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + M + + M + + + + + M + + I + + M M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + M + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia, Lymphoid | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + M + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Alveolar Epithelium, Hyperplasia | 1 2 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Metaplasia | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 4| 7| 4| 6| 7| 7| 4| 4| 6| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 0| 3| 2| 3| 1| 5| 3| 3| 3| 2| 7| 3| 3| 5| 5| 6| 3| 3|
| 4| 4| 6| 4| 4| 4| 4| 2| 4| 3| 4| 4| 6| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Hyperplasia, Cystic | 1 |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 3 2 1 1 1 3 2 1 1 1 3 1 2|
Cortex, Cyst | X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 |
Pigmentation, Melanin | |
Ulcer | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 8| 3| 4| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 0| 3| 9| 5| 3| 3| 3| 3| 5| 5|
| 4| 3| 4| 8| 4| 4| 4| 4| 6| 6| 4| 4| 4| 4| 6| 0| 4| 5| 6| 4| 4| 4| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X |
Clear Cell Focus | X |
Degeneration, Fatty | 1 1 |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | 2 1 |
Hemorrhage | 1 |
Infarct | 4 |
Karyomegaly | 1 1 |
Mitotic Alteration | 1 |
Mixed Cell Focus | X X |
Necrosis | |
Bile Duct, Cyst | X 4 |
Centrilobular, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Angiectasis | 4 |
Inflammation, Chronic | 3 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Focal Cellular Change | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 4 4 4|
Inflammation, Suppurative | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 8| 3| 4| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 0| 3| 9| 5| 3| 3| 3| 3| 5| 5|
| 4| 3| 4| 8| 4| 4| 4| 4| 6| 6| 4| 4| 4| 4| 6| 0| 4| 5| 6| 4| 4| 4| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | |
Hyperplasia | 1 1 1 2 2 |
Hypertrophy | 1 1 1 2 2 1 1 2 1 3 2 1 1 2 2 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + I M + + + + + M + + + + M + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 4 3 4 3 |
Inflammation, Chronic Active | 2 3 2 3 2 3 1 |
__________________________________________________________________________|
Prostate | + + + I + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | |
Hyperplasia, Neutrophil | 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 8| 3| 4| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 0| 3| 9| 5| 3| 3| 3| 3| 5| 5|
| 4| 3| 4| 8| 4| 4| 4| 4| 6| 6| 4| 4| 4| 4| 6| 0| 4| 5| 6| 4| 4| 4| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + |
Iliac, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M + + + + + + + + + + + + M + M M M M M +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + M + M + + + M + M + + + M + M +|
Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +|
Congestion | 1 |
Hyperplasia | 2 2 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M M + + + + M + + + + + + M + + + + M +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 1 2 1 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + M + + + + + M +|
Atrophy | |
Hyperplasia, Lymphoid | 2 |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 4 4 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Metaplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 8| 3| 4| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 0| 3| 9| 5| 3| 3| 3| 3| 5| 5|
| 4| 3| 4| 8| 4| 4| 4| 4| 6| 6| 4| 4| 4| 4| 6| 0| 4| 5| 6| 4| 4| 4| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 1 1 |
Hyperplasia, Cystic | |
Inflammation, Suppurative | 1 |
Metaplasia, Osseous | |
Nephropathy | 1 2 1 1 1 2 1 1 1 1 2 2 1 1 2 2 1 2 2 |
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + M +|
Dilatation | 4 |
Hemorrhage | |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | |
Pigmentation, Melanin | 2 |
Ulcer | 3 |
Transitional Epithelium, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 6| 7| 7| 6| 7| 5| 6| | |
DAY ON TEST | 7| 5| 1| 6| 3| 3| 5| 3| 9| 9| | |
| 1| 6| 1| 4| 4| 4| 8| 4| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + + + + | 56 |
Cyst | | 1 |
Degeneration | | 1 2.0|
Inflammation, Suppurative | | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + | 58 |
Peyer's Patch, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Basophilic Focus | | 2 |
Clear Cell Focus | | 1 |
Degeneration, Fatty | | 9 1.8|
Eosinophilic Focus | | 5 |
Hematopoietic Cell Proliferation | | 3 1.7|
Hemorrhage | | 1 1.0|
Infarct | 3 | 2 3.5|
Karyomegaly | 2 | 3 1.3|
Mitotic Alteration | 4 | 3 2.7|
Mixed Cell Focus | X | 6 |
Necrosis | 1 1 | 4 1.0|
Bile Duct, Cyst | | 3 2.5|
Centrilobular, Necrosis | | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Angiectasis | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 1 1.0|
Focal Cellular Change | 1 | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 6| 7| 7| 6| 7| 5| 6| | |
DAY ON TEST | 7| 5| 1| 6| 3| 3| 5| 3| 9| 9| | |
| 1| 6| 1| 4| 4| 4| 8| 4| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | | 5 3.6|
Inflammation, Suppurative | | 1 3.0|
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Pigmentation, Hemosiderin | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 | 42 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 |
Cyst | | 1 |
Hyperplasia | 1 4 | 11 1.9|
Hypertrophy | 2 1 2 1 2 | 36 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 1 1 | 7 1.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + + + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Ectasia | 3 2 3 | 12 3.1|
Inflammation, Chronic Active | 2 2 | 16 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + M + + + | 53 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 6| 7| 7| 6| 7| 5| 6| | |
DAY ON TEST | 7| 5| 1| 6| 3| 3| 5| 3| 9| 9| | |
| 1| 6| 1| 4| 4| 4| 8| 4| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia, Megakaryocyte | | 1 2.0|
Hyperplasia, Neutrophil | 3 3 | 7 2.4|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
Iliac, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + M + + + + + | 44 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + M + + + M + | 39 |
Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Congestion | | 2 2.0|
Hyperplasia | 1 2 | 10 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + M M + + + + | 45 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 2 1 2 | 15 1.7|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 54 |
Atrophy | 3 | 2 2.5|
Hyperplasia, Lymphoid | | 1 2.0|
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Subcutaneous Tissue, Inflammation, | | |
Chronic | 4 2 | 8 3.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 6| 7| 7| 6| 7| 5| 6| | |
DAY ON TEST | 7| 5| 1| 6| 3| 3| 5| 3| 9| 9| | |
| 1| 6| 1| 4| 4| 4| 8| 4| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization | 1 1 1 1 1 1 2 | 26 1.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | 2 | 4 1.5|
Alveolar Epithelium, Hyperplasia | 1 | 5 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 1 | 2 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 1.0|
Olfactory Epithelium, Atrophy | | 1 1.0|
Olfactory Epithelium, Metaplasia | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hydronephrosis | 2 1 | 5 1.4|
Hyperplasia, Cystic | | 1 1.0|
Inflammation, Suppurative | 2 | 3 1.7|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 1 2 2 2 1 | 41 1.5|
Cortex, Cyst | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Dilatation | | 2 3.5|
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | 4 | 2 3.0|
Pigmentation, Melanin | | 1 2.0|
Ulcer | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 4| 6| 6| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3| 3| 5|
| 2| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4| 0| 6| 6| 8| 5| 4| 4| 4| 4| 4| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + M + + + + + + + + + + +|
Degeneration | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X |
Clear Cell Focus | X |
Degeneration, Fatty | 1 2 1 2 1 1 1 2|
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 1 |
Infarct | 4 4 |
Karyomegaly | |
Mixed Cell Focus | |
Necrosis | |
Vacuolization Cytoplasmic | |
Kupffer Cell, Pigmentation | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation, Chronic | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 3 |
Hyperplasia, Squamous | 2 2 2 3 4 |
Inflammation, Suppurative | 3 2 2 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Hyperplasia | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | A + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 4| 6| 6| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3| 3| 5|
| 2| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4| 0| 6| 6| 8| 5| 4| 4| 4| 4| 4| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | M + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Cyst | |
Hyperplasia | 2 2 1 2 2|
Hypertrophy | 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1|
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + + M + + M + + + + + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | A + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | A + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | A + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
Hyperplasia | |
__________________________________________________________________________|
Preputial Gland | A + + M + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 4 4 |
Inflammation, Chronic Active | 1 4 |
__________________________________________________________________________|
Prostate | M M + + + + + + + + + + + + + + + + I + + M + M +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | A + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 4 2 |
__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 4| 6| 6| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3| 3| 5|
| 2| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4| 0| 6| 6| 8| 5| 4| 4| 4| 4| 4| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + M + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | M + M M + M + + + + + M + M M M M + + + M + + M +|
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | A + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 2 4 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | A + + + M + + + M + + + M + + + + M + M M + I M +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 2 2 |
Hyperplasia, Lymphoid | 2 4 |
__________________________________________________________________________|
Thymus | A I + M M + + + + + + + + + + + + + + M + M + M +|
Atrophy | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic | 4 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | A + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | A + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Metaplasia | 1 |
__________________________________________________________________________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 4| 6| 6| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3| 3| 5|
| 2| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4| 0| 6| 6| 8| 5| 4| 4| 4| 4| 4| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Inflammation, Suppurative | 1 |
Metaplasia, Osseous | |
Nephropathy | 1 1 3 1 1 2 1 1 1 2 1 1 1 1 1 1 2 1 1|
Cortex, Cyst | 2 1 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic | 4 |
Ulcer | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 7| 6| 5| 7| 6| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 3| 2| 3| 1| 5| 3| 3| 6| 3| 5| 5| 3| 3| 3| 3| 5| 9| 2| 3| 3| 6| 3| 4| 7|
| 4| 4| 7| 4| 6| 6| 4| 6| 7| 4| 8| 6| 7| 4| 4| 4| 6| 2| 0| 4| 4| 4| 4| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M M + + + + + + + + + + M +|
Degeneration | |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + + + + A + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + A + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | |
Degeneration, Fatty | 2 2 |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 1 1 |
Infarct | |
Karyomegaly | 2 |
Mixed Cell Focus | X X |
Necrosis | 1 |
Vacuolization Cytoplasmic | |
Kupffer Cell, Pigmentation | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +|
Atrophy | 1 4 |
Inflammation, Chronic | 4 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 2 |
Inflammation, Suppurative | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Degeneration | |
Hyperplasia | 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 7| 6| 5| 7| 6| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 3| 2| 3| 1| 5| 3| 3| 6| 3| 5| 5| 3| 3| 3| 3| 5| 9| 2| 3| 3| 6| 3| 4| 7|
| 4| 4| 7| 4| 6| 6| 4| 6| 7| 4| 8| 6| 7| 4| 4| 4| 6| 2| 0| 4| 4| 4| 4| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + A + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + M + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | X |
Hyperplasia | 3 1 2 |
Hypertrophy | 1 1 1 1 1 2 1 1 3 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + M + + + M + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + A + + + + + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + A + + + + + + + + + + + +|
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + A + + + + + + + + + + + +|
Granuloma Sperm | |
Hyperplasia | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + M + + + M + + + + + + + + + + + +|
Ectasia | |
Inflammation, Chronic Active | 3 4 1 4 |
__________________________________________________________________________|
Prostate | + + + + M + + + M + + + A + + + + + + + + + + + +|
Inflammation, Suppurative | 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + A + + + + + + + + + + + M|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + A + + + + + + + + + + + +|
Atrophy | |
Interstitial Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 1 2 4 2 4|
__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 7| 6| 5| 7| 6| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 3| 2| 3| 1| 5| 3| 3| 6| 3| 5| 5| 3| 3| 3| 3| 5| 9| 2| 3| 3| 6| 3| 4| 7|
| 4| 4| 7| 4| 6| 6| 4| 6| 7| 4| 8| 6| 7| 4| 4| 4| 6| 2| 0| 4| 4| 4| 4| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + M + M + + M + M + M I + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + M + + M + M + + M + M + + + + M + M|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + A + + + + + + + + + + + +|
Congestion | 2 4 2 |
Hematopoietic Cell Proliferation | 2 3|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M M + + M + A + + + + + + M + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 2 2 1 2 2 2 3 2|
Hyperplasia, Lymphoid | 1 1 |
__________________________________________________________________________|
Thymus | + + + + M + + M + + + + A + + + + + + + + + + M +|
Atrophy | |
Epithelial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + A + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic | 4 2 2 4 2 4|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + A + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + A + + + + + + + + + + + +|
Mineralization | 1 1 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + A + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Metaplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +|
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 7| 6| 5| 7| 6| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 3| 2| 3| 1| 5| 3| 3| 6| 3| 5| 5| 3| 3| 3| 3| 5| 9| 2| 3| 3| 6| 3| 4| 7|
| 4| 4| 7| 4| 6| 6| 4| 6| 7| 4| 8| 6| 7| 4| 4| 4| 6| 2| 0| 4| 4| 4| 4| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hydronephrosis | 2 2 2 |
Inflammation, Suppurative | 2|
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 4 1 1 1 1 1 1 1 1 1 |
Cortex, Cyst | 1 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic | 3|
Ulcer | |
Transitional Epithelium, Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 4| 7| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 9| 3| 5| 3| 3| 0| | |
| 6| 4| 4| 4| 5| 4| 6| 4| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 55 |
Degeneration | | 1 3.0|
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
Peyer's Patch, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
Peyer's Patch, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X | 5 |
Clear Cell Focus | X | 2 |
Degeneration, Fatty | 3 1 | 12 1.6|
Eosinophilic Focus | X | 5 |
Hematopoietic Cell Proliferation | 1 | 4 1.0|
Infarct | | 2 4.0|
Karyomegaly | 2 | 2 2.0|
Mixed Cell Focus | X | 3 |
Necrosis | | 1 1.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Kupffer Cell, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy | | 3 2.3|
Inflammation, Chronic | 1 | 2 2.5|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Hyperkeratosis | 1 | 3 1.7|
Hyperplasia, Squamous | | 6 2.5|
Inflammation, Suppurative | | 4 2.3|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Degeneration | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 4| 7| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 9| 3| 5| 3| 3| 0| | |
| 6| 4| 4| 4| 5| 4| 6| 4| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 1 1.0|
Inflammation, Suppurative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy | 1 1 1 1 1 1 1 2 | 46 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Accessory Adrenal Cortical Nodule | | 1 |
Cyst | | 1 |
Hyperplasia | 1 2 2 2 2 | 13 1.8|
Hypertrophy | 1 1 1 | 23 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
Hyperplasia | 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + | 56 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
Follicle, Cyst | | 2 |
Follicular Cell, Hyperplasia | 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 58 |
Granuloma Sperm | | 1 4.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 56 |
Ectasia | 4 | 4 4.0|
Inflammation, Chronic Active | 3 2 4 | 9 2.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 52 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 4| 7| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 9| 3| 5| 3| 3| 0| | |
| 6| 4| 4| 4| 5| 4| 6| 4| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Atrophy | | 1 1.0|
Interstitial Cell, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Hyperplasia, Neutrophil | 4 | 9 2.9|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
Pancreatic, Hyperplasia | | 1 3.0|
Renal, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + M + + + + M | 45 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M + M M M + | 36 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Congestion | | 5 2.8|
Hematopoietic Cell Proliferation | | 3 2.0|
Hyperplasia | 2 1 | 8 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M + + + + + + | 44 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Hematopoietic Cell Proliferation | 2 2 | 16 1.9|
Hyperplasia, Lymphoid | | 4 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + | 48 |
Atrophy | 3 | 1 3.0|
Epithelial Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Subcutaneous Tissue, Inflammation, | | |
Chronic | 4 | 10 3.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Fibrous Osteodystrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 4| 7| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 9| 3| 5| 3| 3| 0| | |
| 6| 4| 4| 4| 5| 4| 6| 4| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Mineralization | 1 1 1 | 16 1.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 58 |
Hemorrhage | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Inflammation, Suppurative | 1 | 3 1.0|
Olfactory Epithelium, Atrophy | | 2 1.0|
Olfactory Epithelium, Metaplasia | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
Metaplasia, Squamous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Hydronephrosis | | 4 2.0|
Inflammation, Suppurative | 3 | 3 2.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 1 1 2 2 1 1 | 39 1.3|
Cortex, Cyst | | 3 1.3|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Dilatation | | 2 3.0|
Inflammation, Chronic | 4 | 3 3.7|
Ulcer | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 4| 6| 4| 5| 4| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 5| 3| 3| 5| 4| 5| 3| 5| 3| 3| 3| 2| 5| 5| 3| 5| 3| 3| 3| 3| 3| 3|
| 5| 3| 3| 6| 3| 3| 6| 3| 6| 2| 6| 3| 3| 3| 7| 6| 6| 3| 6| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + M + + + + A + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + M + + + + + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | X X |
Degeneration, Fatty | 2 1 1 |
Eosinophilic Focus | X|
Focal Cellular Change | |
Hematopoietic Cell Proliferation | |
Infarct | |
Karyomegaly | 1 1|
Mixed Cell Focus | X |
Necrosis | |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Hyperplasia, Squamous | 2 2 2 1 1 1 |
Inflammation, Suppurative | |
Ulcer | 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Ectopic Tissue | |
Erosion | 3 |
Hyperplasia | 2 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Tooth | |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 4| 6| 4| 5| 4| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 5| 3| 3| 5| 4| 5| 3| 5| 3| 3| 3| 2| 5| 5| 3| 5| 3| 3| 3| 3| 3| 3|
| 5| 3| 3| 6| 3| 3| 6| 3| 6| 2| 6| 3| 3| 3| 7| 6| 6| 3| 6| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | 1 1 2 2 2 4 2 |
Hypertrophy | 1 2 1 1 2 2 1 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + + + + + M + M M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 3 |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | |
Inflammation, Chronic Active | 2 2 1 3 1 1 4 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + M M + + + + + + + + + + + + M|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 4| 6| 4| 5| 4| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 5| 3| 3| 5| 4| 5| 3| 5| 3| 3| 3| 2| 5| 5| 3| 5| 3| 3| 3| 3| 3| 3|
| 5| 3| 3| 6| 3| 3| 6| 3| 6| 2| 6| 3| 3| 3| 7| 6| 6| 3| 6| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | 4 3 3 2 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M + M + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M M + M + M + + + I + M + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M I + + + M + + + + M M + + M + + + M M + M + M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Mononuclear Cell | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Suppurative | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 4 4 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 2 1 1 1 1 2 2 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic, Focal | |
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia | 2 2 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Atrophy | |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 4| 6| 4| 5| 4| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 5| 3| 3| 5| 4| 5| 3| 5| 3| 3| 3| 2| 5| 5| 3| 5| 3| 3| 3| 3| 3| 3|
| 5| 3| 3| 6| 3| 3| 6| 3| 6| 2| 6| 3| 3| 3| 7| 6| 6| 3| 6| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 1 2 |
Hyperplasia, Cystic | |
Inflammation, Suppurative | 4 |
Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | |
Ulcer | 4 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3|
| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 4| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + M + M + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | |
Clear Cell Focus | X |
Degeneration, Fatty | 1 |
Eosinophilic Focus | X X X |
Focal Cellular Change | 1 |
Hematopoietic Cell Proliferation | 1 |
Infarct | 4 |
Karyomegaly | 1 |
Mixed Cell Focus | X X |
Necrosis | 3 |
Bile Duct, Cyst | X |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Hyperplasia, Squamous | 1 4 2 4 1 |
Inflammation, Suppurative | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Ectopic Tissue | X |
Erosion | |
Hyperplasia | 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Tooth | + |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3|
| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 4| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cardiomyopathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | 1 2 |
Hypertrophy | 3 3 1 1 1 1 1 1 1 1 3 1 2 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 4 |
__________________________________________________________________________|
Parathyroid Gland | + M + M M + + + M M I + + M M M + M M + M M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | |
Inflammation, Chronic Active | 4 4 2 1 2 3 2 1 2 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + M + + + + + M +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3|
| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 4| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | 3 4 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + + + + + + + M + + + + + M + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + M M + + + + + + M + + M + + M + + + M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + + + + M M M + + + + + + M + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hematopoietic Cell Proliferation | 2 3 3 3 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 |
Hyperplasia, Mononuclear Cell | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Atrophy | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Suppurative | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 4 3 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic, Focal | 3 |
Inflammation, Granulomatous | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
Olfactory Epithelium, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3|
| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 4| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Metaplasia | 1 |
Respiratory Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 1 1 1 1|
Hyperplasia, Cystic | 2 2 |
Inflammation, Suppurative | 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Cortex, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
Ulcer | |
Transitional Epithelium, Hyperplasia | 1 3 |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 55 |
Inflammation, Suppurative | | 3 1.3|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Peyer's Patch, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Basophilic Focus | X | 1 |
Clear Cell Focus | | 3 |
Degeneration, Fatty | | 4 1.3|
Eosinophilic Focus | | 4 |
Focal Cellular Change | | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Infarct | | 1 4.0|
Karyomegaly | | 3 1.0|
Mixed Cell Focus | | 3 |
Necrosis | | 1 3.0|
Bile Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Necrosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Focal Cellular Change | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | | 2 1.0|
Hyperplasia, Squamous | 2 2 1 2 | 15 1.9|
Inflammation, Suppurative | 2 | 2 2.0|
Ulcer | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Degeneration | | 1 2.0|
Ectopic Tissue | | 1 |
Erosion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 2 2.0|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + M + + + + + | 58 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 | 44 1.0|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 |
Hyperplasia | 4 2 1 | 12 2.0|
Hypertrophy | 1 1 2 1 2 1 | 37 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 4 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + M + M M | 35 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Cyst | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Granuloma Sperm | | 2 3.5|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Atrophy | 3 | 1 3.0|
Ectasia | 4 4 | 2 4.0|
Inflammation, Chronic Active | 3 3 | 20 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | M + + + + + + + + + | 54 |
Inflammation, Suppurative | | 2 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Atrophy | | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hyperplasia, Neutrophil | 3 3 2 | 11 2.8|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + M | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + | 44 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + | 58 |
Congestion | | 1 2.0|
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | I + + + + + M M M I | 40 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Hematopoietic Cell Proliferation | 2 3 1 | 13 2.2|
Hyperplasia, Lymphoid | 2 | 8 2.0|
Hyperplasia, Mononuclear Cell | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + | 57 |
Atrophy | | 1 3.0|
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Suppurative | 4 | 2 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 4 | 10 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05133-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:07:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization | 1 1 | 20 1.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic, Focal | | 1 3.0|
Inflammation, Granulomatous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 1.8|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 2 1.0|
Olfactory Epithelium, Atrophy | | 1 1.0|
Olfactory Epithelium, Metaplasia | | 1 1.0|
Respiratory Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hydronephrosis | | 6 1.2|
Hyperplasia, Cystic | | 2 2.0|
Inflammation, Suppurative | | 2 2.5|
Nephropathy | 1 1 1 1 1 1 1 1 1 | 43 1.0|
Cortex, Cyst | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | 4 | 3 3.3|
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
Ulcer | | 1 4.0|
Transitional Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------