TDMS Study 05133-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest ACETONITRILE DATE: 05/20/95
EXPERIMENT: 05133 TEST: 04 TIME: 07:11:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES55073 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 000242
PATHOLOGIST: R. MILLER HAILEY, JAMES R. CAS: 75-05-8
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest ACETONITRILE DATE: 05/20/95
EXPERIMENT: 05133 TEST: 04 TIME: 07:11:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES55073 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 000242
PATHOLOGIST: R. MILLER HAILEY, JAMES R. CAS: 75-05-8
ACETONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 437 457 546 548 563 581 595 595 598 623 |
| 637 650 675 678 698 714 716 729 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 426 434 571 583 595 595 602 623 636 648 |
| 658 664 664 674 692 700 711 714 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 342 537 567 573 595 607 616 636 636 644 |
| 650 658 658 664 665 692 720 727 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
ACETONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 532 554 643 665 692 701 727 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
ACETONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 96.3 96.3 82.3 76.3 64.2 |
| | |
| | |
|50 PPM | 100.0 100.0 100.0 100.0 100.0 96.7 96.7 86.6 74.5 64.4 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 98.3 98.3 98.3 96.3 90.3 70.2 64.2 |
| | |
| | |
|200 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 96.0 92.0 86.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 50 PPM 100 PPM 200 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.2% 64.4% 64.2% 86.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.013N P=1.000N P=1.000N P=0.017N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 613.3 621.7 621.5 644.9 |
|NATURAL DEATHS (C) | (19.8) (19.4) (20.2) (28.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 650.9 653.4 653.4 676.6 |
|(STANDARD ERROR) | (14.5) (14.3) (14.4) (13.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ACETONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 11 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 426 426 517 569 581 622 623 635 641 658 |
| 664 678 681 681 694 699 700 706 706 710 |
| 720 |
| CENSORED DEATHS |
| 5 457 457 457 457 457 457 457 457 457 |
| 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 369 435 548 579 595 602 621 622 639 646 |
| 664 664 665 686 687 711 717 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 10 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 552 570 583 635 643 650 663 664 665 668 |
| 670 670 671 700 704 706 708 712 719 727 |
| 734 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
ACETONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 127 294 329 444 472 491 509 510 510 566 |
| 630 644 650 664 664 678 719 720 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
ACETONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 96.6 94.6 90.4 78.1 57.6 |
| | |
| | |
|50 PPM | 100.0 100.0 100.0 100.0 98.3 96.7 96.7 88.6 74.5 66.5 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 94.0 82.0 58.0 |
| | |
| | |
|200 PPM | 100.0 98.3 98.3 95.0 95.0 91.3 83.2 81.2 71.0 64.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 50 PPM 100 PPM 200 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 57.6% 66.5% 58.0% 64.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.905N P=0.554N P=0.918N P=0.822N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 635.1 614.7 667.3 534.5 |
|NATURAL DEATHS (C) | (19.0) (22.5) (10.9) (37.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 641.5 654.6 665.0 628.5 |
|(STANDARD ERROR) | (18.0) (14.7) (13.3) (18.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ACETONITRILE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
50 PPM = 2
100 PPM = 3
200 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1 4
| 3 221 1 3
| 4 4
| 2 1 31 432 4
95 + 2 2
| 11 33 4 4
| 1 13 2 2 4 4
|
P 90 + 1 1 3 3 4 4
E | 1 1233
R | 4 4
C | 2 32 3 4 4
E 85 + 2 2
N | 11
T | 1 1 232
|
S 80 + 1 1322
U | 1 12 2
R |
V | 1 1
I 75 + 2 2
V | 3 3
A | 1 21
L |
70 + 3 21 1
| 32 11
|
| 13 1
65 + 2 2
| 3 1
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.
ACETONITRILE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
50 PPM = 2
100 PPM = 3
200 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1 3
| 4 4 2 2
| 3 3
| 4 4 1 2 1 2 3 3
95 + 4 4 1 2 12
| 4 4 3 3
| 11 2 33
| 4 4 22
90 + 1 1 33
| 4 4 2 2
P | 3 3
E | 1 1
R 85 + 2 2
C | 4 4 11
E | 121 33
N | 4 4
T 80 + 21 1
| 4 4
S | 44 1 1
U | 11
R 75 + 4 2 2
V | 3 3
I | 1213
V | 4 4
A 70 + 2 2
L | 4 22
| 33
| 11 2 2
65 + 4 4
| 33
| 33
| 11
60 + 113 3
|
| 1 1
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.