TDMS Study 05133-03 Pathology Tables
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
66 WEEK SACRIFICE
Facility: Battelle Northwest
Chemical CAS #: 75-05-8
Lock Date: 05/15/92
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 6| 7| 7| 8| 8| 9| 9| | L |
| 9| 3| 1| 4| 3| 5| 4| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
Pars Distalis, Adenoma | X X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 6| 7| 7| 8| 8| 9| 9| | L |
| 9| 3| 1| 4| 3| 5| 4| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| | A |
100 PPM | 7| 7| 8| 9| 9| 0| 1| 2| | L |
| 4| 9| 1| 0| 3| 9| 6| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | + M + + + + + + | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Bilateral, Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 8 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| | A |
100 PPM | 7| 7| 8| 9| 9| 0| 1| 2| | L |
| 4| 9| 1| 0| 3| 9| 6| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + + M + | 5 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 8 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + M + | 7 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 8 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| | A |
200 PPM | 9| 9| 0| 0| 1| 1| 2| 3| | L |
| 1| 7| 0| 6| 1| 2| 1| 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
Pars Distalis, Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
C-Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| | A |
200 PPM | 9| 9| 0| 0| 1| 1| 2| 3| | L |
| 1| 7| 0| 6| 1| 2| 1| 3| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M M M M + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 4| 4| 4| 4| 4| 4| 4| | A |
400 PPM | 9| 0| 0| 1| 2| 2| 3| 3| | L |
| 7| 5| 7| 0| 0| 8| 5| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
Pars Distalis, Adenoma | X X X X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
C-Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 8 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 4| 4| 4| 4| 4| 4| 4| | A |
400 PPM | 9| 0| 0| 1| 2| 2| 3| 3| | L |
| 7| 5| 7| 0| 0| 8| 5| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
Fibroadenoma | X X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 1| 2| 2| 3| 4| 4| 5| 5| | L |
| 5| 2| 9| 0| 1| 4| 0| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
Pars Distalis, Adenoma | X X | 2 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 8 |
Bilateral, Interstitial Cell, Adenoma| X X X | 3 |
Interstitial Cell, Adenoma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 1| 2| 2| 3| 4| 4| 5| 5| | L |
| 5| 2| 9| 0| 1| 4| 0| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + M | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + M | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 8 |
Keratoacanthoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 1| 2| 2| 6| 6| 6| 6| 6| | L |
| 6| 5| 6| 0| 1| 4| 6| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | + M + + + + + + | 7 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M M M M + | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + | 7 |
Pars Distalis, Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 8 |
Bilateral, Interstitial Cell, Adenoma| X | 1 |
Interstitial Cell, Adenoma | X X X X X X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 1| 2| 2| 6| 6| 6| 6| 6| | L |
| 6| 5| 6| 0| 1| 4| 6| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
200 PPM | 3| 4| 5| 5| 6| 7| 7| 7| | L |
| 0| 9| 3| 6| 9| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | I M + M + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
Pars Distalis, Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
C-Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 8 |
Bilateral, Interstitial Cell, Adenoma| X X X | 3 |
Interstitial Cell, Adenoma | X X X X X | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
200 PPM | 3| 4| 5| 5| 6| 7| 7| 7| | L |
| 0| 9| 3| 6| 9| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + M + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| | A |
400 PPM | 3| 4| 5| 5| 5| 5| 6| 9| | L |
| 8| 2| 1| 2| 5| 6| 7| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M M + + | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + I | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 8 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ACETONITRILE Date: 03/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| | A |
400 PPM | 3| 4| 5| 5| 5| 5| 6| 9| | L |
| 8| 2| 1| 2| 5| 6| 7| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + M + M | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
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