TDMS Study 05133-03 Pathology Tables
NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 66 WEEK SACRIFICE Facility: Battelle Northwest Chemical CAS #: 75-05-8 Lock Date: 05/15/92 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 6| 7| 7| 8| 8| 9| 9| | L | | 9| 3| 1| 4| 3| 5| 4| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + | 8 | __________________________________________________________________________|____________| Heart | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + | 8 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 8 | Pars Distalis, Adenoma | X X X | 3 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | __________________________________________________________________________|____________| Uterus | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + M + + | 6 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 2 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 6| 7| 7| 8| 8| 9| 9| | L | | 9| 3| 1| 4| 3| 5| 4| 8| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + | 8 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | __________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | __________________________________________________________________________|____________| Nose | + + + + + + + + | 8 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 8 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 3 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| | A | 100 PPM | 7| 7| 8| 9| 9| 0| 1| 2| | L | | 4| 9| 1| 0| 3| 9| 6| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + | 7 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + | 8 | __________________________________________________________________________|____________| Heart | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | __________________________________________________________________________|____________| Adrenal Medulla | + M + + + + + + | 7 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | __________________________________________________________________________|____________| Uterus | + + + + + + + + | 8 | Bilateral, Polyp Stromal | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 8 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 4 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| | A | 100 PPM | 7| 7| 8| 9| 9| 0| 1| 2| | L | | 4| 9| 1| 0| 3| 9| 6| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + M + + M + | 5 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 8 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + M + | 7 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + | 8 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 8 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| | A | 200 PPM | 9| 9| 0| 0| 1| 1| 2| 3| | L | | 1| 7| 0| 6| 1| 2| 1| 3| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + | 8 | __________________________________________________________________________|____________| Heart | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + | 8 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + | 7 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 8 | Pars Distalis, Adenoma | X X | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | C-Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | __________________________________________________________________________|____________| Uterus | + + + + + + + + | 8 | Polyp Stromal | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| | A | 200 PPM | 9| 9| 0| 0| 1| 1| 2| 3| | L | | 1| 7| 0| 6| 1| 2| 1| 3| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M M M M + | 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + M + + | 7 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + | 8 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | __________________________________________________________________________|____________| Thymus | + + + + + + + M | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | Fibroadenoma | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | __________________________________________________________________________|____________| Nose | + + + + + + + + | 8 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 8 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 4| 4| 4| 4| 4| 4| 4| | A | 400 PPM | 9| 0| 0| 1| 2| 2| 3| 3| | L | | 7| 5| 7| 0| 0| 8| 5| 9| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | __________________________________________________________________________|____________| Mesentery | + + | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + | 8 | __________________________________________________________________________|____________| Heart | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + | 8 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + | 7 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 8 | Pars Distalis, Adenoma | X X X X | 4 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | C-Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + | 8 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | __________________________________________________________________________|____________| Uterus | + + + + + + + + | 8 | Polyp Stromal | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 7| 7| 7| 7| 7| 7| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 4| 4| 4| 4| 4| 4| 4| | A | 400 PPM | 9| 0| 0| 1| 2| 2| 3| 3| | L | | 7| 5| 7| 0| 0| 8| 5| 9| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + | 7 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + | 8 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | __________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | Fibroadenoma | X X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | __________________________________________________________________________|____________| Nose | + + + + + + + + | 8 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 8 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| | A | CONTROL | 1| 2| 2| 3| 4| 4| 5| 5| | L | | 5| 2| 9| 0| 1| 4| 0| 4| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + | 8 | __________________________________________________________________________|____________| Heart | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + | 8 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M | 7 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 8 | Pars Distalis, Adenoma | X X | 2 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + | 8 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Prostate | + + + + + + + + | 8 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + | 8 | __________________________________________________________________________|____________| Testes | + + + + + + + + | 8 | Bilateral, Interstitial Cell, Adenoma| X X X | 3 | Interstitial Cell, Adenoma | X X X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| | A | CONTROL | 1| 2| 2| 3| 4| 4| 5| 5| | L | | 5| 2| 9| 0| 1| 4| 0| 4| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + + + M | 6 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + M | 6 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + + + + | 7 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + | 8 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | __________________________________________________________________________|____________| Thymus | + + + M + + + + | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 8 | Keratoacanthoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | __________________________________________________________________________|____________| Nose | + + + + + + + + | 8 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 8 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A | 100 PPM | 1| 2| 2| 6| 6| 6| 6| 6| | L | | 6| 5| 6| 0| 1| 4| 6| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + | 8 | __________________________________________________________________________|____________| Heart | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | __________________________________________________________________________|____________| Adrenal Medulla | + M + + + + + + | 7 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | __________________________________________________________________________|____________| Parathyroid Gland | + M + M M M M + | 3 | __________________________________________________________________________|____________| Pituitary Gland | M + + + + + + + | 7 | Pars Distalis, Adenoma | X X | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + | 8 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Prostate | + + + + + + + + | 8 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + | 8 | __________________________________________________________________________|____________| Testes | + + + + + + + + | 8 | Bilateral, Interstitial Cell, Adenoma| X | 1 | Interstitial Cell, Adenoma | X X X X X X X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A | 100 PPM | 1| 2| 2| 6| 6| 6| 6| 6| | L | | 6| 5| 6| 0| 1| 4| 6| 8| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M + + + + | 7 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | __________________________________________________________________________|____________| Thymus | + + + M + + + + | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | __________________________________________________________________________|____________| Nose | + + + + + + + + | 8 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 8 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A | 200 PPM | 3| 4| 5| 5| 6| 7| 7| 7| | L | | 0| 9| 3| 6| 9| 7| 8| 9| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + | 8 | __________________________________________________________________________|____________| Heart | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | __________________________________________________________________________|____________| Adrenal Medulla | I M + M + + + + | 5 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 8 | Pars Distalis, Adenoma | X X | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | C-Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + | 8 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Prostate | + + + + + + + + | 8 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + | 8 | __________________________________________________________________________|____________| Testes | + + + + + + + + | 8 | Bilateral, Interstitial Cell, Adenoma| X X X | 3 | Interstitial Cell, Adenoma | X X X X X | 5 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A | 200 PPM | 3| 4| 5| 5| 6| 7| 7| 7| | L | | 0| 9| 3| 6| 9| 7| 8| 9| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node | + + | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + M + + | 6 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + M + + | 7 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + | 8 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | __________________________________________________________________________|____________| Thymus | M + + + + + + + | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | __________________________________________________________________________|____________| Nose | + + + + + + + + | 8 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 8 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| | A | 400 PPM | 3| 4| 5| 5| 5| 5| 6| 9| | L | | 8| 2| 1| 2| 5| 6| 7| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 8 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | __________________________________________________________________________|____________| Mesentery | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + | 8 | __________________________________________________________________________|____________| Heart | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + | 8 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | __________________________________________________________________________|____________| Parathyroid Gland | M M + + M M + + | 4 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + I | 7 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + | 8 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Prostate | + + + + + + + + | 8 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + | 8 | __________________________________________________________________________|____________| Testes | + + + + + + + + | 8 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05133-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ACETONITRILE Date: 03/18/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:01:11 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| | | | 6| 6| 6| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| | A | 400 PPM | 3| 4| 5| 5| 5| 5| 6| 9| | L | | 8| 2| 1| 2| 5| 6| 7| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + M + M + M | 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + | 7 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + | 8 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | __________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + | 8 | __________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | __________________________________________________________________________|____________| Nose | + + + + + + + + | 8 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 8 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------