TDMS Study 05133-03 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
ACETONITRILE
NTP Experiment-Test: 05133-03 Report: PEIRPT05
Study Type: CHRONIC Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:11:12
Facility: Battelle Northwest
Chemical CAS #: 75-05-8
Lock Date: 05/15/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05133-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ACETONITRILE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:11:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 56 56 56 56
Scheduled Sacrifice 8 8 8 8
Early Deaths
Moribund Sacrifice 24 25 21 14
Accidently Killed 1
Natural Death 2 1 5
Survivors
Terminal Sacrifice 23 21 26 29
Animals Examined Microscopically 56 56 56 56
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (55) (55) (56) (53)
Intestine Small, Ileum (55) (55) (54) (53)
Liver (56) (56) (56) (54)
Fibrous Histiocytoma, Metastatic, Skin 2 (4%)
Hepatocellular Adenoma 1 (2%)
Mesentery (10) (9) (8) (11)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (11%)
Lipoma 1 (11%) 1 (13%)
Pancreas (56) (56) (56) (54)
Pharynx (1)
Squamous Cell Papilloma 1 (100%)
Salivary Glands (56) (54) (56) (55)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (56) (56) (56) (55)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Heart (56) (56) (56) (55)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (56) (56) (56) (54)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
Adrenal Medulla (56) (55) (55) (55)
Neoplasm NOS 1 (2%)
Page 2
NTP Experiment-Test: 05133-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ACETONITRILE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:11:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Islets, Pancreatic (56) (56) (56) (54)
Adenoma 2 (4%)
Carcinoma 1 (2%) 1 (2%)
Parathyroid Gland (52) (52) (51) (52)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Pituitary Gland (56) (56) (55) (53)
Schwannoma Malignant, Metastatic, Brain 1 (2%)
Pars Distalis, Adenoma 27 (48%) 26 (46%) 30 (55%) 33 (62%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (56) (56) (56) (54)
C-Cell, Adenoma 3 (5%) 4 (7%) 5 (9%) 5 (9%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 2 (4%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (54) (50) (55) (53)
Adenoma 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Carcinoma 4 (7%) 1 (2%) 4 (7%) 3 (6%)
Ovary (56) (56) (56) (55)
Granulosa-Theca Tumor Malignant 2 (4%)
Uterus (56) (56) (56) (55)
Carcinoma 1 (2%)
Hemangioma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 7 (13%) 4 (7%) 8 (14%) 6 (11%)
Bilateral, Polyp Stromal 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (56) (56) (56) (54)
Lymph Node (7) (6) (9) (8)
Renal, Granulosa-Theca Tumor Malignant,
Metastatic, Ovary 1 (17%)
Lymph Node, Bronchial (49) (44) (45) (48)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Lymph Node, Mandibular (54) (54) (52) (49)
Page 3
NTP Experiment-Test: 05133-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ACETONITRILE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:11:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Lymph Node, Mesenteric (54) (55) (55) (55)
Lymph Node, Mediastinal (56) (53) (53) (54)
Fibrous Histiocytoma, Metastatic 1 (2%)
Spleen (56) (56) (56) (53)
Thymus (56) (56) (55) (55)
Thymoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (56) (56) (56) (55)
Carcinoma 2 (4%) 4 (7%) 3 (5%) 3 (5%)
Fibroadenoma 12 (21%) 21 (38%) 18 (32%) 18 (33%)
Fibroadenoma, Multiple 4 (7%) 6 (11%) 4 (7%) 7 (13%)
Fibrosarcoma 1 (2%)
Skin (56) (56) (56) (56)
Basal Cell Carcinoma 1 (2%)
Fibroma 1 (2%) 1 (2%)
Fibroma, Multiple 1 (2%)
Fibrous Histiocytoma 2 (4%)
Squamous Cell Carcinoma 1 (2%)
Trichoepithelioma 1 (2%)
Pinna, Melanoma NOS 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (55) (56) (56) (55)
Schwannoma Malignant, Metastatic, Brain 1 (2%)
Cranium, Carcinoma, Metastatic, Zymbal's
Gland 1 (2%)
Skeletal Muscle (1)
Fibrous Histiocytoma, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (56) (56) (56) (55)
Astrocytoma NOS 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Glioma NOS 1 (2%) 1 (2%)
Cranial Nerve, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05133-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ACETONITRILE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:11:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (56) (56) (56) (54)
Alveolar/Bronchiolar Adenoma 2 (4%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2) (1)
Carcinoma 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (56) (56) (56) (54)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
Lipoma 1 (2%)
Urinary Bladder (56) (56) (55) (53)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(56) *(56) *(56) *(56)
Leukemia Mononuclear 18 (32%) 23 (41%) 20 (36%) 24 (43%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05133-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ACETONITRILE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:11:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 48 50 51
Total Primary Neoplasms 91 108 105 112
Total Animals with Benign Neoplasms 41 40 43 43
Total Benign Neoplasms 59 71 74 78
Total Animals with Malignant Neoplasms 29 29 23 28
Total Malignant Neoplasms 31 36 29 32
Total Animals with Metastatic Neoplasms 2 6 1
Total Metastatic Neoplasm 2 16 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1 2 2
Total Uncertain Neoplasms 1 1 2 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05133-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ACETONITRILE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:11:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 56 56 56 56
Scheduled Sacrifice 8 8 8 8
Early Deaths
Moribund Sacrifice 36 26 35 26
Natural Death 1 8 4 5
Survivors
Terminal Sacrifice 11 13 9 17
Other 1
Animals Examined Microscopically 56 56 56 56
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (56) (50) (54) (53)
Intestine Small, Jejunum (55) (50) (54) (52)
Carcinoma 1 (2%)
Fibrosarcoma 1 (2%)
Intestine Small, Ileum (55) (50) (54) (51)
Liver (56) (55) (56) (56)
Hepatocellular Carcinoma 1 (2%) 2 (4%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%) 3 (5%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mesentery (10) (9) (9) (12)
Pancreas (56) (55) (56) (56)
Adenoma 1 (2%)
Pharynx (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
Stomach, Forestomach (56) (55) (56) (55)
Stomach, Glandular (56) (54) (56) (55)
Tongue (2) (1)
Squamous Cell Carcinoma 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (56) (55) (56) (56)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05133-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ACETONITRILE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:11:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Medulla (56) (53) (53) (56)
Pheochromocytoma Malignant 2 (4%) 2 (4%) 1 (2%)
Pheochromocytoma Benign 2 (4%) 11 (21%) 10 (19%) 6 (11%)
Bilateral, Pheochromocytoma Benign 2 (4%) 4 (8%) 2 (4%) 1 (2%)
Islets, Pancreatic (56) (55) (56) (56)
Adenoma 1 (2%) 4 (7%) 4 (7%) 1 (2%)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (2%) 3 (5%) 1 (2%)
Pituitary Gland (56) (53) (56) (54)
Pars Distalis, Adenoma 27 (48%) 29 (55%) 25 (45%) 23 (43%)
Pars Intermedia, Adenoma 2 (4%)
Thyroid Gland (56) (55) (56) (56)
Bilateral, C-Cell, Adenoma 1 (2%)
Bilateral, C-Cell, Carcinoma 1 (2%)
C-Cell, Adenoma 6 (11%) 5 (9%) 7 (13%) 6 (11%)
C-Cell, Carcinoma 3 (5%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (56) (55) (56) (56)
Preputial Gland (55) (55) (55) (56)
Adenoma 1 (2%)
Carcinoma 5 (9%) 1 (2%) 2 (4%) 1 (2%)
Testes (56) (55) (56) (56)
Osteosarcoma, Metastatic, Bone 1 (2%)
Bilateral, Interstitial Cell, Adenoma 28 (50%) 30 (55%) 33 (59%) 42 (75%)
Interstitial Cell, Adenoma 11 (20%) 13 (24%) 15 (27%) 8 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (56) (55) (56) (56)
Lymph Node (12) (8) (15) (13)
Axillary, Osteosarcoma, Metastatic, Bone 1 (7%)
Lymph Node, Bronchial (47) (48) (46) (45)
Osteosarcoma, Metastatic, Bone 1 (2%)
Lymph Node, Mandibular (49) (51) (52) (54)
Lymph Node, Mesenteric (55) (55) (55) (56)
Page 8
NTP Experiment-Test: 05133-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ACETONITRILE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:11:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Lymph Node, Mediastinal (56) (53) (56) (56)
Spleen (56) (55) (56) (56)
Fibrosarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma 2 (4%)
Thymus (55) (52) (54) (56)
Thymoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (55) (55) (56) (56)
Carcinoma 1 (2%) 1 (2%)
Fibroadenoma 2 (4%) 2 (4%)
Skin (56) (55) (56) (56)
Basal Cell Adenoma 1 (2%) 1 (2%)
Fibroma 3 (5%) 2 (4%) 3 (5%)
Fibroma, Multiple 1 (2%)
Fibrosarcoma 1 (2%)
Hemangiopericytoma 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%) 4 (7%)
Trichoepithelioma 1 (2%)
Sebaceous Gland, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (56) (55) (56) (56)
Humerus, Osteosarcoma 1 (2%)
Rib, Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (56) (55) (56) (56)
Astrocytoma NOS 1 (2%)
Glioma Malignant 1 (2%)
Glioma NOS 1 (2%)
Oligodendroglioma NOS 1 (2%)
Sarcoma, Metastatic, Spleen 1 (2%)
Meninges, Meningioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05133-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ACETONITRILE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:11:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (56) (55) (56) (56)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Neoplasm NOS, Metastatic, Uncertain Primary
Site 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2)
Pinna, Schwannoma Benign 1 (50%)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (56) (55) (56) (56)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (56) (55) (56) (56)
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(56) *(56) *(56) *(56)
Leukemia Mononuclear 29 (52%) 32 (57%) 35 (63%) 32 (57%)
Mesothelioma NOS 3 (5%) 5 (9%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05133-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ACETONITRILE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:11:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 56 55 56 56
Total Primary Neoplasms 132 153 154 150
Total Animals with Benign Neoplasms 53 53 53 55
Total Benign Neoplasms 86 106 104 102
Total Animals with Malignant Neoplasms 36 36 38 34
Total Malignant Neoplasms 43 41 47 45
Total Animals with Metastatic Neoplasms 3 1 1 2
Total Metastatic Neoplasm 4 1 6 2
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 3 6 3 3
Total Uncertain Neoplasms 7 10 6 6
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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