TDMS Study 05133-03 Pathology Tables
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
Facility: Battelle Northwest
Chemical CAS #: 75-05-8
Lock Date: 05/15/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 3| 4| 1| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 0| 2| 5| 3| 3| 3| 5| 2| 3| 3| 3| 2| 2| 3| 5| 2| 7| 5| 0| 3| 9| 2| 6| 3| 3|
| 6| 7| 7| 4| 4| 4| 7| 1| 4| 4| 4| 5| 1| 4| 7| 3| 7| 7| 5| 4| 7| 9| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic | |
Hematopoietic Cell Proliferation | 4 |
Hepatodiaphragmatic Nodule | X X |
Infarct | |
Vacuolization Cytoplasmic | 4 3 3 |
Bile Duct, Hyperplasia | |
Hepatocyte, Hyperplasia | 4 2 4 |
Hepatocyte, Necrosis | |
Portal, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Hemorrhage | |
Fat, Inflammation, Granulomatous | |
Fat, Necrosis | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 2 1 2 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Mineralization | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Squamous | |
Inflammation, Suppurative | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Thrombosis | |
Endocardium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 3| 4| 1| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 0| 2| 5| 3| 3| 3| 5| 2| 3| 3| 3| 2| 2| 3| 5| 2| 7| 5| 0| 3| 9| 2| 6| 3| 3|
| 6| 7| 7| 4| 4| 4| 7| 1| 4| 4| 4| 5| 1| 4| 7| 3| 7| 7| 5| 4| 7| 9| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia | |
Vacuolization Cytoplasmic | 2 2 1 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X|
Pars Distalis, Cyst | 4 |
Pars Distalis, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 |
C-Cell, Hyperplasia | 1 1 4 1 3 1 3 2 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3 3 |
Hyperplasia | 3 3 |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Thrombosis | X |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + M + + M + + + |
Hemorrhage | 4 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 3| 4| 1| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 0| 2| 5| 3| 3| 3| 5| 2| 3| 3| 3| 2| 2| 3| 5| 2| 7| 5| 0| 3| 9| 2| 6| 3| 3|
| 6| 7| 7| 4| 4| 4| 7| 1| 4| 4| 4| 5| 1| 4| 7| 3| 7| 7| 5| 4| 7| 9| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 4 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hemorrhage | |
Hyperplasia, Re Cell | 4 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Hydrocephalus | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 2 2 2 |
Hyperplasia | 2 2 |
Inflammation, Suppurative | 2 1 2 2 |
Metaplasia, Squamous | 2 2 3 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Infiltration Cellular, Histiocyte | 2 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Alveolus, Fibrosis | 1 |
Alveolus, Inflammation, Chronic | 1 1 |
Alveolus, Inflammation, Suppurative | 2 |
Pleura, Fibrosis | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 3| 4| 1| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 0| 2| 5| 3| 3| 3| 5| 2| 3| 3| 3| 2| 2| 3| 5| 2| 7| 5| 0| 3| 9| 2| 6| 3| 3|
| 6| 7| 7| 4| 4| 4| 7| 1| 4| 4| 4| 5| 1| 4| 7| 3| 7| 7| 5| 4| 7| 9| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | 2 2 |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 2 2 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | 3|
Hemorrhage | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 1 2 1 1 1 2 3 2 1 1 1 2 2 4 1 2 1|
Cortex, Necrosis | 2 4 2|
Renal Tubule, Mineralization | 2 1 2 2 1 2 1 2 2 2 1 1 1 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 3| 7| 3| 7| 7| 7| 3| 4| 7| 7| 7| 4| 6| 7| 5| 6| 7| 7| 5| 4|
DAY ON TEST | 3| 5| 2| 5| 3| 1| 3| 3| 3| 3| 3| 6| 5| 1| 0| 3| 5| 6| 3| 3| 2| 3| 2| 8| 7|
| 4| 7| 7| 7| 4| 0| 4| 1| 4| 4| 4| 0| 7| 4| 2| 4| 7| 2| 4| 0| 5| 4| 1| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 1|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X |
Infarct | 4 |
Vacuolization Cytoplasmic | 3 4 3 1 4 4 2|
Bile Duct, Hyperplasia | 3 |
Hepatocyte, Hyperplasia | 3 3 |
Hepatocyte, Necrosis | 2 |
Portal, Fibrosis | 4 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage | 4 |
Fat, Inflammation, Granulomatous | 3 |
Fat, Necrosis | 3 3 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 2 1|
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Mineralization | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Hyperplasia, Squamous | 2 2 1 |
Inflammation, Suppurative | 2 2 |
Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + I + + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Thrombosis | X |
Endocardium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 3| 7| 3| 7| 7| 7| 3| 4| 7| 7| 7| 4| 6| 7| 5| 6| 7| 7| 5| 4|
DAY ON TEST | 3| 5| 2| 5| 3| 1| 3| 3| 3| 3| 3| 6| 5| 1| 0| 3| 5| 6| 3| 3| 2| 3| 2| 8| 7|
| 4| 7| 7| 7| 4| 0| 4| 1| 4| 4| 4| 0| 7| 4| 2| 4| 7| 2| 4| 0| 5| 4| 1| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 |
Vacuolization Cytoplasmic | 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 4 3 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
C-Cell, Hyperplasia | 2 2 2 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + + + + +|
Ectasia | 3 3 3 3 3 |
Hyperplasia | |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Thrombosis | |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | 4 |
__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + M + + + + + + + + + + M + + +|
Hemorrhage | 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 3| 7| 3| 7| 7| 7| 3| 4| 7| 7| 7| 4| 6| 7| 5| 6| 7| 7| 5| 4|
DAY ON TEST | 3| 5| 2| 5| 3| 1| 3| 3| 3| 3| 3| 6| 5| 1| 0| 3| 5| 6| 3| 3| 2| 3| 2| 8| 7|
| 4| 7| 7| 7| 4| 0| 4| 1| 4| 4| 4| 0| 7| 4| 2| 4| 7| 2| 4| 0| 5| 4| 1| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 2 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hemorrhage | 4 |
Hyperplasia, Re Cell | 4 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + I + + + + + + + + + + + + + + + + + + + +|
Vertebra, Fracture | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 1 |
Hydrocephalus | 2 2 |
Necrosis | |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + A + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Hyperplasia | 2 |
Inflammation, Suppurative | 2 |
Metaplasia, Squamous | 2 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | 2 1 1 1 2 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Fibrosis | 1 |
Alveolus, Inflammation, Chronic | |
Alveolus, Inflammation, Suppurative | 1 |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 3| 7| 3| 7| 7| 7| 3| 4| 7| 7| 7| 4| 6| 7| 5| 6| 7| 7| 5| 4|
DAY ON TEST | 3| 5| 2| 5| 3| 1| 3| 3| 3| 3| 3| 6| 5| 1| 0| 3| 5| 6| 3| 3| 2| 3| 2| 8| 7|
| 4| 7| 7| 7| 4| 0| 4| 1| 4| 4| 4| 0| 7| 4| 2| 4| 7| 2| 4| 0| 5| 4| 1| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 2 |
Respiratory Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | |
Hemorrhage | 3 3 |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 1 2 1 2 2 2 1 1 2 1 2 2 1 2 1 |
Cortex, Necrosis | 3 3|
Renal Tubule, Mineralization | 2 1 1 2 1 1 2 1 2 1 1 1 1 1 1 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 0| 3| | |
| 4| 4| 4| 4| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 55 |
Lumen, Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 55 |
Lumen, Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 56 |
Basophilic Focus | X X X X X | 40 |
Clear Cell Focus | | 2 |
Degeneration, Cystic | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Hepatodiaphragmatic Nodule | | 7 |
Infarct | | 1 4.0|
Vacuolization Cytoplasmic | 1 | 11 2.9|
Bile Duct, Hyperplasia | 3 | 2 3.0|
Hepatocyte, Hyperplasia | 3 3 | 7 3.1|
Hepatocyte, Necrosis | | 1 2.0|
Portal, Fibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 10 |
Hemorrhage | | 1 4.0|
Fat, Inflammation, Granulomatous | | 1 3.0|
Fat, Necrosis | | 7 3.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 56 |
Acinus, Atrophy | 2 1 1 | 15 1.5|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 56 |
Duct, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 56 |
Edema | | 2 2.0|
Hyperplasia, Squamous | | 3 1.7|
Inflammation, Suppurative | | 2 2.0|
Ulcer | | 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 55 |
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 0| 3| | |
| 4| 4| 4| 4| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + | 56 |
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | | 2 2.0|
Thrombosis | | 1 |
Endocardium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 56 |
Hemorrhage | | 1 2.0|
Hyperplasia | | 1 2.0|
Vacuolization Cytoplasmic | | 6 2.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 56 |
Hyperplasia | | 5 2.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 56 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 56 |
Cyst | X X X X | 13 |
Pars Distalis, Cyst | | 1 4.0|
Pars Distalis, Hyperplasia | 3 | 9 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 56 |
Dilatation | | 1 1.0|
C-Cell, Hyperplasia | 1 1 1 2 | 26 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 54 |
Ectasia | | 11 3.0|
Hyperplasia | | 2 3.0|
Inflammation, Suppurative | | 4 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + | 56 |
Cyst | X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + | 56 |
Hemorrhage | | 1 2.0|
Thrombosis | | 1 |
Endometrium, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 0| 3| | |
| 4| 4| 4| 4| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 56 |
Hyperplasia, Re Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + | 7 |
Lumbar, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + | 49 |
Hemorrhage | 2 3 | 4 3.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 54 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 54 |
Hyperplasia, Lymphoid | | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 56 |
Hemorrhage | 2 2 | 11 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 56 |
Fibrosis | | 1 3.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Re Cell | | 2 4.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 56 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 55 |
Vertebra, Fracture | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Hemorrhage | | 4 2.0|
Hydrocephalus | 2 | 4 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 0| 3| | |
| 4| 4| 4| 4| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 55 |
Foreign Body | 2 | 8 2.0|
Hyperplasia | 1 2 | 5 1.8|
Inflammation, Suppurative | | 5 1.8|
Metaplasia, Squamous | 2 | 7 2.1|
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Hemorrhage | 1 1 1 1 | 43 1.0|
Infiltration Cellular, Histiocyte | 1 | 11 1.4|
Alveolar Epithelium, Hyperplasia | 1 2 1 | 6 1.2|
Alveolus, Fibrosis | | 2 1.0|
Alveolus, Inflammation, Chronic | 2 | 3 1.3|
Alveolus, Inflammation, Suppurative | | 2 1.5|
Pleura, Fibrosis | | 3 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 55 |
Foreign Body | | 2 2.0|
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | | 1 2.0|
Goblet Cell, Respiratory Epithelium, | | |
Hypertrophy | | 3 2.0|
Respiratory Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Cataract | | 1 3.0|
Hemorrhage | | 2 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 56 |
Nephropathy, Chronic | 2 2 1 1 1 1 | 40 1.6|
Cortex, Necrosis | | 5 2.8|
Renal Tubule, Mineralization | 2 1 2 1 1 | 44 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 4| 7| 4| 3| 6| 7| 7| 6| 6| 7| 7| 4| 6| 7| 4|
DAY ON TEST | 1| 3| 0| 1| 3| 5| 3| 6| 1| 3| 5| 3| 5| 2| 6| 3| 3| 0| 9| 0| 3| 5| 9| 3| 5|
| 3| 5| 7| 7| 5| 7| 5| 5| 9| 7| 7| 5| 7| 8| 5| 5| 5| 0| 3| 6| 5| 7| 8| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Granuloma, Multifocal | 3 3 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Vacuolization Cytoplasmic | 4 1 2 4 4 1 3 |
Hepatocyte, Degeneration, Cystic | 2 |
Hepatocyte, Hyperplasia | 3 4 4 3 |
Serosa, Cyst | |
Serosa, Hemorrhage | |
__________________________________________________________________________|
Mesentery | + + + + + |
Hemorrhage | 4 |
Artery, Inflammation | 3 |
Fat, Inflammation, Granulomatous | 3 3 3 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 2 1 1 2 2 1 1 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia, Squamous | 2 2 |
Inflammation, Suppurative | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 4| 7| 4| 3| 6| 7| 7| 6| 6| 7| 7| 4| 6| 7| 4|
DAY ON TEST | 1| 3| 0| 1| 3| 5| 3| 6| 1| 3| 5| 3| 5| 2| 6| 3| 3| 0| 9| 0| 3| 5| 9| 3| 5|
| 3| 5| 7| 7| 5| 7| 5| 5| 9| 7| 7| 5| 7| 8| 5| 5| 5| 0| 3| 6| 5| 7| 8| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Vacuolization Cytoplasmic | 2 2 4 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 4 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X |
Pars Distalis, Cyst | 4 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 3 1 1 4 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + M + + + + +|
Ectasia | 3 3 |
Hyperplasia | 3 3 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | 4 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Pancreatic, Hemorrhage | |
Renal, Hemorrhage | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + M + + + + + + M M + M M + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 4| 7| 4| 3| 6| 7| 7| 6| 6| 7| 7| 4| 6| 7| 4|
DAY ON TEST | 1| 3| 0| 1| 3| 5| 3| 6| 1| 3| 5| 3| 5| 2| 6| 3| 3| 0| 9| 0| 3| 5| 9| 3| 5|
| 3| 5| 7| 7| 5| 7| 5| 5| 9| 7| 7| 5| 7| 8| 5| 5| 5| 0| 3| 6| 5| 7| 8| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Re Cell | 4 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Suppurative | 3 3 |
Ulcer | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hydrocephalus | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Hyperplasia | 2 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Infiltration Cellular, Histiocyte | 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Fibrosis | 3 |
Alveolus, Inflammation, Chronic | |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 4| 7| 4| 3| 6| 7| 7| 6| 6| 7| 7| 4| 6| 7| 4|
DAY ON TEST | 1| 3| 0| 1| 3| 5| 3| 6| 1| 3| 5| 3| 5| 2| 6| 3| 3| 0| 9| 0| 3| 5| 9| 3| 5|
| 3| 5| 7| 7| 5| 7| 5| 5| 9| 7| 7| 5| 7| 8| 5| 5| 5| 0| 3| 6| 5| 7| 8| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 2 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 4 3 |
Respiratory Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Hemorrhage | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4 |
Nephropathy, Chronic | 2 1 1 2 2 1 2 3 2 1 1 2 2 1 |
Cortex, Necrosis | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 3 |
Renal Tubule, Inflammation, | |
Suppurative | 3 |
Renal Tubule, Mineralization | 1 1 1 1 2 2 2 1 1 1 3 1 1 1 1 1 2 1|
Renal Tubule, Pigmentation, | |
Hemosiderin | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 7| 6| 6| 4| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 3| 8| 3| 3| 1| 3| 7| 2| 2| 3| 5| 3| 3| 2| 1| 0| 9| 5| 3| 3|
| 3| 1| 5| 5| 5| 5| 8| 5| 5| 4| 5| 1| 3| 1| 5| 7| 5| 5| 1| 3| 3| 3| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Lumen, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Granuloma, Multifocal | 3 3 |
Hematopoietic Cell Proliferation | 4 |
Hepatodiaphragmatic Nodule | X X X |
Vacuolization Cytoplasmic | 4 3 2 4 3 |
Hepatocyte, Degeneration, Cystic | |
Hepatocyte, Hyperplasia | 3 4 3 3 |
Serosa, Cyst | |
Serosa, Hemorrhage | |
__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | |
Artery, Inflammation | |
Fat, Inflammation, Granulomatous | 3 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + M + + + + + + + M + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Hyperplasia, Squamous | 1 3 3 2 |
Inflammation, Suppurative | 2 3 3 |
Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 7| 6| 6| 4| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 3| 8| 3| 3| 1| 3| 7| 2| 2| 3| 5| 3| 3| 2| 1| 0| 9| 5| 3| 3|
| 3| 1| 5| 5| 5| 5| 8| 5| 5| 4| 5| 1| 3| 1| 5| 7| 5| 5| 1| 3| 3| 3| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Vacuolization Cytoplasmic | 3 2 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X|
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 2 1 3 1 1 1 1 2 2 2 1 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + M + + + + + + + + + M M + + + +|
Ectasia | 3 3 |
Hyperplasia | 3 |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Endometrium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Pancreatic, Hemorrhage | 2 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + + + + M + M + + + + + + + + + + + M + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + M + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 7| 6| 6| 4| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 3| 8| 3| 3| 1| 3| 7| 2| 2| 3| 5| 3| 3| 2| 1| 0| 9| 5| 3| 3|
| 3| 1| 5| 5| 5| 5| 8| 5| 5| 4| 5| 1| 3| 1| 5| 7| 5| 5| 1| 3| 3| 3| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 3 1 |
Hyperplasia, Lymphoid | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + + + M + + M + +|
Hemorrhage | 2 3 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 |
Hyperplasia, Re Cell | 4 |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Inflammation, Suppurative | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 4 |
Hydrocephalus | 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Hyperplasia | |
Metaplasia, Squamous | 2 2 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | 2 3 1 2 1 1 1 1 2 1 1|
Alveolar Epithelium, Hyperplasia | 2 2 1|
Alveolus, Fibrosis | |
Alveolus, Inflammation, Chronic | 1 |
Pleura, Fibrosis | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 3|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 7| 6| 6| 4| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 3| 8| 3| 3| 1| 3| 7| 2| 2| 3| 5| 3| 3| 2| 1| 0| 9| 5| 3| 3|
| 3| 1| 5| 5| 5| 5| 8| 5| 5| 4| 5| 1| 3| 1| 5| 7| 5| 5| 1| 3| 3| 3| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Hemorrhage | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy, Chronic | 2 1 4 2 2 1 2 3 1 2 2 1 1 2 1 2 1 4 1 2 1|
Cortex, Necrosis | 2 3 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Inflammation, | |
Suppurative | |
Renal Tubule, Mineralization | 1 1 3 1 1 2 1 1 1 1 1 1 2 1 1 2 1 1 1 1 |
Renal Tubule, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 7| 4| 7| | |
DAY ON TEST | 7| 0| 5| 3| 7| 1| | |
| 9| 6| 7| 5| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
100 PPM | 1| 2| 2| 2| 2| 2| | L |
| 9| 0| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 55 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 56 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 54 |
Lumen, Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 55 |
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 55 |
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + | 56 |
Atrophy | | 1 4.0|
Basophilic Focus | X X X X X | 41 |
Clear Cell Focus | X | 2 |
Granuloma, Multifocal | | 4 3.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Hepatodiaphragmatic Nodule | | 3 |
Vacuolization Cytoplasmic | 3 2 | 14 2.9|
Hepatocyte, Degeneration, Cystic | | 1 2.0|
Hepatocyte, Hyperplasia | 4 | 9 3.4|
Serosa, Cyst | X | 1 |
Serosa, Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 9 |
Hemorrhage | | 1 4.0|
Artery, Inflammation | | 1 3.0|
Fat, Inflammation, Granulomatous | 3 | 6 3.0|
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 56 |
Acinus, Atrophy | 2 2 1 | 22 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 56 |
Edema | | 3 2.3|
Hyperplasia, Squamous | | 6 2.2|
Inflammation, Suppurative | 3 | 5 2.6|
Ulcer | | 3 3.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 7| 4| 7| | |
DAY ON TEST | 7| 0| 5| 3| 7| 1| | |
| 9| 6| 7| 5| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
100 PPM | 1| 2| 2| 2| 2| 2| | L |
| 9| 0| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + | 56 |
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | 2 | 2 2.0|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 56 |
Hyperplasia | 4 | 2 3.5|
Vacuolization Cytoplasmic | 2 1 | 11 2.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 55 |
Hyperplasia | | 6 2.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 56 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 56 |
Cyst | X | 17 |
Pars Distalis, Cyst | | 1 4.0|
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | | 5 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 56 |
C-Cell, Hyperplasia | 1 1 1 1 | 39 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 50 |
Ectasia | | 4 3.0|
Hyperplasia | | 4 3.0|
Inflammation, Suppurative | | 3 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + | 56 |
Cyst | | 3 |
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + | 56 |
Cervix, Endometrium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 7| 4| 7| | |
DAY ON TEST | 7| 0| 5| 3| 7| 1| | |
| 9| 6| 7| 5| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
100 PPM | 1| 2| 2| 2| 2| 2| | L |
| 9| 0| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Re Cell | 4 4 | 3 4.0|
Myelofibrosis | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | | 6 |
Pancreatic, Hemorrhage | | 1 2.0|
Renal, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + | 44 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 54 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 55 |
Hemorrhage | | 3 2.3|
Hyperplasia, Lymphoid | 4 | 1 4.0|
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 53 |
Hemorrhage | | 7 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 56 |
Fibrosis | | 2 3.0|
Hyperplasia, Re Cell | 4 | 3 4.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 56 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 56 |
Galactocele | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
Acanthosis | | 1 3.0|
Inflammation, Suppurative | | 2 3.0|
Ulcer | | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 56 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Hemorrhage | 3 | 5 2.6|
Hydrocephalus | 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 7| 4| 7| | |
DAY ON TEST | 7| 0| 5| 3| 7| 1| | |
| 9| 6| 7| 5| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
100 PPM | 1| 2| 2| 2| 2| 2| | L |
| 9| 0| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 56 |
Foreign Body | | 2 2.0|
Hyperplasia | | 1 2.0|
Metaplasia, Squamous | 2 | 5 1.8|
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Hemorrhage | 1 1 1 1 | 37 1.0|
Infiltration Cellular, Histiocyte | 1 1 | 17 1.5|
Alveolar Epithelium, Hyperplasia | | 5 1.8|
Alveolus, Fibrosis | | 1 3.0|
Alveolus, Inflammation, Chronic | | 1 1.0|
Pleura, Fibrosis | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + | 55 |
Foreign Body | 2 | 5 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 2 | 2 2.0|
Goblet Cell, Respiratory Epithelium, | | |
Hypertrophy | | 2 2.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 3 3.3|
Respiratory Epithelium, Hyperplasia | 1 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 56 |
Infarct | | 1 4.0|
Nephropathy, Chronic | 2 1 2 | 38 1.7|
Cortex, Necrosis | | 2 2.5|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 3.0|
Renal Tubule, Inflammation, | | |
Suppurative | | 1 3.0|
Renal Tubule, Mineralization | 1 2 1 1 | 42 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 7| 4| 7| | |
DAY ON TEST | 7| 0| 5| 3| 7| 1| | |
| 9| 6| 7| 5| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
100 PPM | 1| 2| 2| 2| 2| 2| | L |
| 9| 0| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Pigmentation, | | |
Hemosiderin | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 56 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 5| 7| 6| 4| 7| 5| 5| 6| 7| 4| 7| 6| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 9| 3| 2| 5| 3| 6| 5| 5| 3| 5| 3| 7| 5| 3| 3| 3| 3| 6|
| 5| 5| 7| 3| 9| 5| 5| 7| 5| 5| 7| 5| 6| 5| 1| 5| 7| 5| 1| 7| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
200 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinum, Cyst | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Lumen, Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | |
Eosinophilic Focus | X |
Granuloma, Multifocal | |
Hepatodiaphragmatic Nodule | X X X X |
Vacuolization Cytoplasmic | 2 4 1 1 |
Hepatocyte, Degeneration, Cystic | 2|
Hepatocyte, Hyperplasia | 4 3 |
Hepatocyte, Necrosis | 2 |
Serosa, Hemorrhage | |
__________________________________________________________________________|
Mesentery | + + + + + |
Hemorrhage | |
Artery, Inflammation | 4 |
Fat, Inflammation, Granulomatous | 2 4 |
Fat, Necrosis | 2 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 2 1 2 2 2 1 1 2 1 1 2 |
Artery, Inflammation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + I|
Diverticulum | 3 3 |
Edema | |
Hyperplasia, Basal Cell | |
Hyperplasia, Squamous | 3 2 |
Inflammation, Suppurative | 2 |
Necrosis | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 5| 7| 6| 4| 7| 5| 5| 6| 7| 4| 7| 6| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 9| 3| 2| 5| 3| 6| 5| 5| 3| 5| 3| 7| 5| 3| 3| 3| 3| 6|
| 5| 5| 7| 3| 9| 5| 5| 7| 5| 5| 7| 5| 6| 5| 1| 5| 7| 5| 1| 7| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
200 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +|
Cyst | X X X X X X |
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 2 1 1 1 1 3 1 1 2 2 1 4 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3|
Hyperplasia | 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Endometrium, Hyperplasia | |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + |
Axillary, Hyperplasia, Lymphoid | 4 |
Iliac, Pigmentation | |
Pancreatic, Pigmentation | |
Renal, Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + M + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 5| 7| 6| 4| 7| 5| 5| 6| 7| 4| 7| 6| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 9| 3| 2| 5| 3| 6| 5| 5| 3| 5| 3| 7| 5| 3| 3| 3| 3| 6|
| 5| 5| 7| 3| 9| 5| 5| 7| 5| 5| 7| 5| 6| 5| 1| 5| 7| 5| 1| 7| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
200 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + + + M + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hemorrhage | 4 |
Hyperplasia, Re Cell | 4 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Epithelium, Hyperplasia | 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Granulomatous | 4 |
Ulcer | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Hyperplasia | 1 2 |
Inflammation, Suppurative | 2 1 |
Metaplasia, Squamous | 2 2 |
Mineralization | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Infiltration Cellular, Histiocyte | 1 2 2 1 1 1 1 1 1 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 1 3 |
Alveolus, Fibrosis | 1 |
Pleura, Fibrosis | 1 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 5| 7| 6| 4| 7| 5| 5| 6| 7| 4| 7| 6| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 9| 3| 2| 5| 3| 6| 5| 5| 3| 5| 3| 7| 5| 3| 3| 3| 3| 6|
| 5| 5| 7| 3| 9| 5| 5| 7| 5| 5| 7| 5| 6| 5| 1| 5| 7| 5| 1| 7| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
200 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Hemorrhage | |
Retina, Atrophy | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 1 2 1 2 3 1 1 2 1 2 2 1 1 2 2 2 1 2|
Cortex, Necrosis | 2 3 3 2 |
Renal Tubule, Mineralization | 1 1 1 2 1 1 2 1 2 2 2 1 1 1 1 2 1 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 4| 3| 7| 5| 7| 4| 4| 6| 7| 4| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 7| 3| 3| 3| 5| 5| 9| 3| 8| 7| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 5| 8| 3| 1|
| 7| 6| 5| 4| 5| 7| 7| 3| 5| 5| 1| 5| 2| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinum, Cyst | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | |
Granuloma, Multifocal | 3 3 |
Hepatodiaphragmatic Nodule | X X X |
Vacuolization Cytoplasmic | 3 4 2 4 3 4 4|
Hepatocyte, Degeneration, Cystic | |
Hepatocyte, Hyperplasia | 2 4 |
Hepatocyte, Necrosis | 1 1 |
Serosa, Hemorrhage | 2 |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
Artery, Inflammation | |
Fat, Inflammation, Granulomatous | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 1 2 1 2 2 2 2 2 2 |
Artery, Inflammation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Edema | 4 3 3 3|
Hyperplasia, Basal Cell | |
Hyperplasia, Squamous | 2 4 2 4 2|
Inflammation, Suppurative | 3 3 3|
Necrosis | 1|
Ulcer | 2 4 4 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 4| 3| 7| 5| 7| 4| 4| 6| 7| 4| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 7| 3| 3| 3| 5| 5| 9| 3| 8| 7| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 5| 8| 3| 1|
| 7| 6| 5| 4| 5| 7| 7| 3| 5| 5| 1| 5| 2| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Vacuolization Cytoplasmic | 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 2 1 3 1 1 1 2 1 1 2 2 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3 |
Hyperplasia | 3 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Endometrium, Hyperplasia | 3 |
Endometrium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node | + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Iliac, Pigmentation | 2 |
Pancreatic, Pigmentation | 3 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + M M M + M M + + + M M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + M + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 4| 3| 7| 5| 7| 4| 4| 6| 7| 4| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 7| 3| 3| 3| 5| 5| 9| 3| 8| 7| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 5| 8| 3| 1|
| 7| 6| 5| 4| 5| 7| 7| 3| 5| 5| 1| 5| 2| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hemorrhage | 4 |
Hyperplasia, Re Cell | |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Inflammation, Granulomatous | 4 |
Ulcer | 2 |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 2 1 4 1 |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Hyperplasia | 3 |
Inflammation, Suppurative | 4 1 1 1 |
Metaplasia, Squamous | 2 2 1 2 1 |
Mineralization | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | 1 1 2 1 2 |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Fibrosis | |
Pleura, Fibrosis | 1 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 4| 3| 7| 5| 7| 4| 4| 6| 7| 4| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 5| 7| 3| 3| 3| 5| 5| 9| 3| 8| 7| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 5| 8| 3| 1|
| 7| 6| 5| 4| 5| 7| 7| 3| 5| 5| 1| 5| 2| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Hemorrhage | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 3 |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 2 |
Respiratory Epithelium, Hyperplasia | 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Hemorrhage | 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 2 1 1 1 4 3 1 1 1 2 1 1 2|
Cortex, Necrosis | 2 |
Renal Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + I|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 5| 7| | |
DAY ON TEST | 3| 3| 5| 6| 8| 3| | |
| 5| 5| 7| 5| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
200 PPM | 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 56 |
Mediastinum, Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 56 |
Lumen, Parasite Metazoan | X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 55 |
Lumen, Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 56 |
Basophilic Focus | X X X X | 38 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | | 1 |
Granuloma, Multifocal | | 2 3.0|
Hepatodiaphragmatic Nodule | X | 8 |
Vacuolization Cytoplasmic | 3 | 12 2.9|
Hepatocyte, Degeneration, Cystic | | 1 2.0|
Hepatocyte, Hyperplasia | | 4 3.3|
Hepatocyte, Necrosis | | 3 1.3|
Serosa, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Hemorrhage | 4 4 | 2 4.0|
Artery, Inflammation | | 1 4.0|
Fat, Inflammation, Granulomatous | 3 2 | 4 2.8|
Fat, Necrosis | 3 | 4 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 56 |
Acinus, Atrophy | 1 1 2 | 29 1.6|
Artery, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 55 |
Diverticulum | | 2 3.0|
Edema | 3 | 5 3.2|
Hyperplasia, Basal Cell | 1 | 1 1.0|
Hyperplasia, Squamous | 2 | 8 2.6|
Inflammation, Suppurative | | 4 2.8|
Necrosis | | 1 1.0|
Ulcer | | 5 3.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 5| 7| | |
DAY ON TEST | 3| 3| 5| 6| 8| 3| | |
| 5| 5| 7| 5| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
200 PPM | 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + | 56 |
Aorta, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 56 |
Hemorrhage | | 1 4.0|
Vacuolization Cytoplasmic | 2 1 | 5 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 55 |
Angiectasis | | 1 4.0|
Hyperplasia | 3 | 3 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 56 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 51 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 55 |
Cyst | X X | 14 |
Pars Distalis, Hyperplasia | 3 | 3 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 56 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 1 1 2 | 36 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 55 |
Ectasia | 3 | 10 3.0|
Hyperplasia | 3 | 4 3.0|
Inflammation, Suppurative | | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + | 56 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + | 56 |
Cervix, Endometrium, Hyperplasia | | 1 3.0|
Endometrium, Hyperplasia | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 5| 7| | |
DAY ON TEST | 3| 3| 5| 6| 8| 3| | |
| 5| 5| 7| 5| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
200 PPM | 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 56 |
Hyperplasia, Re Cell | | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node | | 9 |
Axillary, Hyperplasia, Lymphoid | | 1 4.0|
Iliac, Pigmentation | | 1 2.0|
Pancreatic, Pigmentation | | 1 3.0|
Renal, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 45 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 52 |
Hyperplasia, Lymphoid | 3 | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 55 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 53 |
Hemorrhage | | 3 1.7|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 56 |
Fibrosis | | 1 3.0|
Hemorrhage | | 2 4.0|
Hyperplasia, Re Cell | | 1 4.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + | 55 |
Hyperplasia, Lymphoid | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 56 |
Galactocele | X | 2 4.0|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
Acanthosis | | 1 1.0|
Inflammation, Granulomatous | | 2 4.0|
Ulcer | | 1 2.0|
Subcutaneous Tissue, Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Hemorrhage | | 8 1.9|
Hydrocephalus | 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 5| 7| | |
DAY ON TEST | 3| 3| 5| 6| 8| 3| | |
| 5| 5| 7| 5| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
200 PPM | 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 56 |
Foreign Body | 2 | 4 2.0|
Hyperplasia | | 3 2.0|
Inflammation, Suppurative | | 6 1.7|
Metaplasia, Squamous | | 7 1.7|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Hemorrhage | 1 1 1 1 | 40 1.0|
Infiltration Cellular, Histiocyte | 3 1 | 17 1.4|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Alveolus, Fibrosis | | 1 1.0|
Pleura, Fibrosis | | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 56 |
Foreign Body | | 1 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 2 | 3 2.3|
Goblet Cell, Respiratory Epithelium, | | |
Hypertrophy | 2 | 2 2.0|
Respiratory Epithelium, Hyperplasia | | 2 2.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 4 |
Cataract | | 2 3.0|
Hemorrhage | 3 | 2 3.0|
Retina, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 56 |
Nephropathy, Chronic | 3 2 1 1 1 | 38 1.7|
Cortex, Necrosis | | 5 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 5| 7| | |
DAY ON TEST | 3| 3| 5| 6| 8| 3| | |
| 5| 5| 7| 5| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
200 PPM | 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Mineralization | 2 2 1 1 1 | 48 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 4| 7| 6| 7| 6| 7| 6| 6| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 7| 5| 3| 5| 3| 1| 3| 7| 2| 7| 6| 5| 3| 5| 2| 3| 5| 3| 3| 3| 3| 3| 7| 7|
| 4| 0| 8| 4| 7| 4| 8| 4| 2| 3| 9| 6| 7| 4| 7| 1| 4| 7| 4| 4| 4| 4| 4| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + A +|
Lumen, Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Lumen, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + A +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Degeneration, Cystic | 1 |
Granuloma, Multifocal | |
Hepatodiaphragmatic Nodule | X X X X X X |
Mixed Cell Focus | X |
Vacuolization Cytoplasmic | 4 3 1 4 2 2 2 1 |
Hepatocyte, Degeneration, Cystic | 3 1 |
Hepatocyte, Hyperplasia | 4 4 1 3 3|
__________________________________________________________________________|
Mesentery | + + + + + + + |
Hemorrhage | |
Fat, Inflammation, Granulomatous | 4 3 3 3 3 |
Fat, Necrosis | 4 3 3 2 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +|
Acinus, Atrophy | 1 2 2 2 2 2 2 2 2 1 2 1 |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia, Basal Cell | 1 1 |
Hyperplasia, Squamous | 4 4 3 |
Inflammation, Suppurative | 4 3 3 |
Ulcer | 4 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +|
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Thrombosis | |
Endocardium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 4| 7| 6| 7| 6| 7| 6| 6| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 7| 5| 3| 5| 3| 1| 3| 7| 2| 7| 6| 5| 3| 5| 2| 3| 5| 3| 3| 3| 3| 3| 7| 7|
| 4| 0| 8| 4| 7| 4| 8| 4| 2| 3| 9| 6| 7| 4| 7| 1| 4| 7| 4| 4| 4| 4| 4| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + A +|
Mineralization | 2 |
Vacuolization Cytoplasmic | 2 3 2 1 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + + + + + + A +|
Cyst | X X X X X X X|
Pars Distalis, Cyst | 4 |
Pars Distalis, Hyperplasia | 3 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
C-Cell, Hyperplasia | 2 1 1 2 4 2 2 1 1 1 2 1 1 1 2 2 4|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3 |
Hyperplasia | 3 3 |
Inflammation, Suppurative | 3 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + + M + + + + + + + + + + + + + + + M + M M|
Hemorrhage | 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 3 2 3 3 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A +|
Developmental Malformation | X|
Fibrosis | |
Hematopoietic Cell Proliferation | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 4| 7| 6| 7| 6| 7| 6| 6| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 7| 5| 3| 5| 3| 1| 3| 7| 2| 7| 6| 5| 3| 5| 2| 3| 5| 3| 3| 3| 3| 3| 7| 7|
| 4| 0| 8| 4| 7| 4| 8| 4| 2| 3| 9| 6| 7| 4| 7| 1| 4| 7| 4| 4| 4| 4| 4| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 3 |
Ulcer | |
Subcutaneous Tissue, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Periosteum, Cranium, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + A +|
Foreign Body | 2 2 2 |
Hyperplasia | |
Inflammation, Suppurative | 2 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | 1 2 4 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Inflammation, Chronic | 1 |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + A +|
Foreign Body | 2 2 |
Hemorrhage | 3 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 4| 7| 6| 7| 6| 7| 6| 6| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 7| 5| 3| 5| 3| 1| 3| 7| 2| 7| 6| 5| 3| 5| 2| 3| 5| 3| 3| 3| 3| 3| 7| 7|
| 4| 0| 8| 4| 7| 4| 8| 4| 2| 3| 9| 6| 7| 4| 7| 1| 4| 7| 4| 4| 4| 4| 4| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + A +|
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Hemorrhage | 3 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +|
Nephropathy, Chronic | 2 2 2 2 1 2 2 2 1 3 4 2 1 2 2 2 1 2|
Cortex, Necrosis | 3 3 |
Renal Tubule, Mineralization | 1 1 2 1 1 2 2 2 2 1 1 3 1 2 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + I + + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 4| 4| 3| 7| 6| 6| 7| 4| 7| 7| 6| 4| 7| 5| 7|
DAY ON TEST | 3| 3| 5| 9| 3| 3| 3| 2| 0| 3| 5| 2| 9| 3| 2| 7| 3| 5| 3| 3| 7| 5| 3| 9| 3|
| 4| 4| 7| 3| 4| 4| 4| 9| 7| 4| 7| 7| 4| 4| 9| 2| 4| 7| 4| 4| 9| 7| 4| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
Lumen, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + I + + + + +|
Lumen, Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Degeneration, Cystic | |
Granuloma, Multifocal | 3 3|
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X |
Vacuolization Cytoplasmic | 1 1 3 4 4 2 4 2 |
Hepatocyte, Degeneration, Cystic | 3|
Hepatocyte, Hyperplasia | 4 4 4 3 |
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | |
Fat, Inflammation, Granulomatous | 3 |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 1 2 2 2 2 2 1 2 1|
Artery, Inflammation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Basal Cell | |
Hyperplasia, Squamous | 3 4 3 |
Inflammation, Suppurative | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + A + + + + + + + + + +|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + A + + + + + + + + + +|
Cardiomyopathy | 2 |
Thrombosis | X |
Endocardium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 4| 4| 3| 7| 6| 6| 7| 4| 7| 7| 6| 4| 7| 5| 7|
DAY ON TEST | 3| 3| 5| 9| 3| 3| 3| 2| 0| 3| 5| 2| 9| 3| 2| 7| 3| 5| 3| 3| 7| 5| 3| 9| 3|
| 4| 4| 7| 3| 4| 4| 4| 9| 7| 4| 7| 7| 4| 4| 9| 2| 4| 7| 4| 4| 9| 7| 4| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + M + + + + + + + + + +|
Mineralization | |
Vacuolization Cytoplasmic | 2 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M A + + M + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
Cyst | X X X X X X |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 2 4 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + A M + + + + + + + + +|
Ectasia | 3 3 3 3 3 3 3 |
Hyperplasia | 3 |
Inflammation, Suppurative | 3 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + A + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Re Cell | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + + + + + + A + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + A + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hemorrhage | 3 2 2 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 4 3 4 |
Hematopoietic Cell Proliferation | |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 4| 4| 3| 7| 6| 6| 7| 4| 7| 7| 6| 4| 7| 5| 7|
DAY ON TEST | 3| 3| 5| 9| 3| 3| 3| 2| 0| 3| 5| 2| 9| 3| 2| 7| 3| 5| 3| 3| 7| 5| 3| 9| 3|
| 4| 4| 7| 3| 4| 4| 4| 9| 7| 4| 7| 7| 4| 4| 9| 2| 4| 7| 4| 4| 9| 7| 4| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Ulcer | 4|
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + A + + + + + + + + + +|
Fibrosis | |
Periosteum, Cranium, Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hemorrhage | 2 2 |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + A + + + + + + + + + +|
Foreign Body | 2 |
Hyperplasia | 1 3 1 1 |
Inflammation, Suppurative | 3 2 |
Metaplasia, Squamous | 2 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Infiltration Cellular, Histiocyte | 2 2 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Inflammation, Chronic | |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +|
Foreign Body | 2 |
Hemorrhage | |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 1 3 |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 3 3 2 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
Olfactory Epithelium, Metaplasia | 3 |
Respiratory Epithelium, Hyperplasia | 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 4| 4| 3| 7| 6| 6| 7| 4| 7| 7| 6| 4| 7| 5| 7|
DAY ON TEST | 3| 3| 5| 9| 3| 3| 3| 2| 0| 3| 5| 2| 9| 3| 2| 7| 3| 5| 3| 3| 7| 5| 3| 9| 3|
| 4| 4| 7| 3| 4| 4| 4| 9| 7| 4| 7| 7| 4| 4| 9| 2| 4| 7| 4| 4| 9| 7| 4| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + A + + + + M + + + + +|
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | |
Hemorrhage | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +|
Nephropathy, Chronic | 2 2 3 1 2 1 1 2 2 3 4 1 1 1 2 1 1|
Cortex, Necrosis | 1 2 2 |
Renal Tubule, Mineralization | 2 1 1 1 2 1 1 1 1 2 1 2 1 2 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
400 PPM | 4| 4| 4| 4| 4| 4| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 53 |
Lumen, Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 53 |
Lumen, Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 54 |
Angiectasis | | 1 4.0|
Basophilic Focus | X X X X X | 42 |
Degeneration, Cystic | | 1 1.0|
Granuloma, Multifocal | 2 | 3 2.7|
Hepatodiaphragmatic Nodule | X | 8 |
Mixed Cell Focus | | 2 |
Vacuolization Cytoplasmic | 2 3 2 1 | 20 2.4|
Hepatocyte, Degeneration, Cystic | | 3 2.3|
Hepatocyte, Hyperplasia | 2 | 10 3.2|
__________________________________________________________________________|____________|
Mesentery | + + | 11 |
Hemorrhage | 4 | 1 4.0|
Fat, Inflammation, Granulomatous | 3 | 7 3.1|
Fat, Necrosis | 3 | 9 3.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 54 |
Acinus, Atrophy | 2 2 2 | 27 1.7|
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 54 |
Hyperplasia, Basal Cell | | 2 1.0|
Hyperplasia, Squamous | 4 | 7 3.6|
Inflammation, Suppurative | | 3 3.3|
Ulcer | 4 | 5 3.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 54 |
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + | 55 |
Aorta, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
400 PPM | 4| 4| 4| 4| 4| 4| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | | 2 2.0|
Thrombosis | | 1 |
Endocardium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 54 |
Mineralization | | 1 2.0|
Vacuolization Cytoplasmic | 3 | 8 2.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 55 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 54 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 52 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 53 |
Cyst | X X | 15 |
Pars Distalis, Cyst | | 1 4.0|
Pars Distalis, Hyperplasia | | 3 3.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 54 |
C-Cell, Hyperplasia | 1 2 1 1 4 1 | 39 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + + | 53 |
Ectasia | 3 3 | 14 3.0|
Hyperplasia | | 3 3.0|
Inflammation, Suppurative | | 6 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + | 55 |
Cyst | | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 54 |
Hyperplasia, Re Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | | 8 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 48 |
Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
400 PPM | 4| 4| 4| 4| 4| 4| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 55 |
Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + | 54 |
Hemorrhage | 2 | 11 2.5|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 53 |
Developmental Malformation | | 1 |
Fibrosis | | 3 3.7|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 55 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
Inflammation, Granulomatous | | 1 3.0|
Ulcer | 4 | 2 4.0|
Subcutaneous Tissue, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 55 |
Fibrosis | | 1 3.0|
Periosteum, Cranium, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 55 |
Hemorrhage | | 2 2.0|
Hydrocephalus | 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 54 |
Foreign Body | | 4 2.0|
Hyperplasia | | 4 1.5|
Inflammation, Suppurative | | 3 2.3|
Metaplasia, Squamous | | 3 1.7|
__________________________________________________________________________|____________|
Lung | + + + + + + | 54 |
Hemorrhage | 1 1 1 1 1 | 38 1.0|
Infiltration Cellular, Histiocyte | 1 | 13 1.5|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
400 PPM | 4| 4| 4| 4| 4| 4| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Inflammation, Chronic | | 1 1.0|
Pleura, Fibrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 54 |
Foreign Body | | 3 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 2 3.0|
Inflammation, Suppurative | | 2 2.0|
Goblet Cell, Respiratory Epithelium, | | |
Hypertrophy | | 4 2.8|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 3.0|
Olfactory Epithelium, Metaplasia | | 1 3.0|
Respiratory Epithelium, Hyperplasia | | 1 3.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 53 |
Epithelium, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Cataract | | 1 3.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 54 |
Nephropathy, Chronic | 1 1 2 2 1 | 40 1.8|
Cortex, Necrosis | | 5 2.2|
Renal Tubule, Mineralization | 1 2 2 1 1 | 41 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 4| 3| 5| 7| 6| 6| 6| 4| 7| 7| 5|
DAY ON TEST | 9| 9| 3| 3| 8| 5| 8| 3| 5| 2| 6| 5| 2| 3| 5| 9| 8| 2| 4| 0| 7| 5| 2| 3| 6|
| 3| 9| 7| 2| 5| 1| 3| 3| 1| 4| 6| 2| 3| 3| 6| 4| 7| 1| 6| 9| 9| 6| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Lumen, Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Lumen, Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 1 4 1 1 2 1 1 4 1 |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 1 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 2 |
Mixed Cell Focus | |
Vacuolization Cytoplasmic | 3 3 2 3 4 |
Bile Duct, Hyperplasia | 3 |
Hepatocyte, Necrosis | 1 2 1 1 |
Portal, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + + + |
Hemorrhage | 4 4 |
Fat, Inflammation, Granulomatous | 3 |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 2 1 2 2 2 2 2 1 1 2|
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Edema | |
Inflammation, Suppurative | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Aorta, Inflammation | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 4| 3| 5| 7| 6| 6| 6| 4| 7| 7| 5|
DAY ON TEST | 9| 9| 3| 3| 8| 5| 8| 3| 5| 2| 6| 5| 2| 3| 5| 9| 8| 2| 4| 0| 7| 5| 2| 3| 6|
| 3| 9| 7| 2| 5| 1| 3| 3| 1| 4| 6| 2| 3| 3| 6| 4| 7| 1| 6| 9| 9| 6| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 |
Atrium, Thrombosis | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 1 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 2 1 3 4 2 3 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | 4 |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 3 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Ectasia | 3 3 3 3 3 3 3 3 3 3|
Hyperplasia | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 2 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | |
Necrosis | |
Germinal Epithelium, Atrophy | 4 4 4 4 4 4 4 |
Interstitial Cell, Hyperplasia | 1 2 1 3 2 1 2 2 2|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 4| 3| 5| 7| 6| 6| 6| 4| 7| 7| 5|
DAY ON TEST | 9| 9| 3| 3| 8| 5| 8| 3| 5| 2| 6| 5| 2| 3| 5| 9| 8| 2| 4| 0| 7| 5| 2| 3| 6|
| 3| 9| 7| 2| 5| 1| 3| 3| 1| 4| 6| 2| 3| 3| 6| 4| 7| 1| 6| 9| 9| 6| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | 4 4 3 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Inflammation, Granulomatous | 3 |
Lumbar, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + M + + + + + + M + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + M + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pigmentation | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 3 3 |
Hemorrhage | |
Hyperplasia, Re Cell | 4 4 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | |
Inflammation, Granulomatous | 2 |
Ulcer | 2 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
Hemorrhage | 3 1 4 |
Hydrocephalus | 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 4| 3| 5| 7| 6| 6| 6| 4| 7| 7| 5|
DAY ON TEST | 9| 9| 3| 3| 8| 5| 8| 3| 5| 2| 6| 5| 2| 3| 5| 9| 8| 2| 4| 0| 7| 5| 2| 3| 6|
| 3| 9| 7| 2| 5| 1| 3| 3| 1| 4| 6| 2| 3| 3| 6| 4| 7| 1| 6| 9| 9| 6| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation, Suppurative | 2 4 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus | X |
Hemorrhage | 1 1 1 1 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | 1 2 4|
Alveolar Epithelium, Hyperplasia | 4 2|
Alveolus, Fibrosis | 2 |
Alveolus, Inflammation, Chronic | 1 1 2 1 |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 2 2 |
Hemorrhage | 3 3 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 2 |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 2 1 3 3 2 |
Respiratory Epithelium, Hyperplasia | 2 3 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 4 3 2 1 3 2 4 2 2 1 2 4 2 1 2 3 1 2 2 2 3 |
Thrombosis | X |
Cortex, Necrosis | 3 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Metaplasia, Squamous | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 4| 4| 5| 7| 4| 7| 5| 4| 5| 5| 7| 4| 6| 7| 4| 6| 7| 6| 7| 6| 4|
DAY ON TEST | 8| 8| 3| 5| 5| 1| 2| 3| 7| 0| 3| 9| 9| 1| 0| 5| 8| 3| 5| 7| 3| 7| 3| 8| 5|
| 6| 4| 3| 6| 6| 8| 0| 3| 2| 1| 9| 2| 7| 1| 7| 6| 5| 3| 6| 9| 3| 4| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X|
Clear Cell Focus | X X X X |
Degeneration, Cystic | 1 1 4 2 4 2 2 |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | |
Mixed Cell Focus | |
Vacuolization Cytoplasmic | 3 3 1 2 |
Bile Duct, Hyperplasia | 3 |
Hepatocyte, Necrosis | 1 1 1 |
Portal, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + + + |
Hemorrhage | 4 |
Fat, Inflammation, Granulomatous | |
Fat, Necrosis | 3 4 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 2 2 2 2 2|
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 2 |
Edema | 2 |
Inflammation, Suppurative | 2 2 2 |
Ulcer | 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1|
Aorta, Inflammation | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 4| 4| 5| 7| 4| 7| 5| 4| 5| 5| 7| 4| 6| 7| 4| 6| 7| 6| 7| 6| 4|
DAY ON TEST | 8| 8| 3| 5| 5| 1| 2| 3| 7| 0| 3| 9| 9| 1| 0| 5| 8| 3| 5| 7| 3| 7| 3| 8| 5|
| 6| 4| 3| 6| 6| 8| 0| 3| 2| 1| 9| 2| 7| 1| 7| 6| 5| 3| 6| 9| 3| 4| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2|
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 1 2 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 1 1 |
Follicle, Dilatation | 4 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3 3 3 3 3 3|
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 3 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 1 2|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Suppurative | 4 |
Necrosis | 4 |
Germinal Epithelium, Atrophy | 4 4 4 |
Interstitial Cell, Hyperplasia | 3 3 3 1 1 3 3 2 3|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 4| 4| 5| 7| 4| 7| 5| 4| 5| 5| 7| 4| 6| 7| 4| 6| 7| 6| 7| 6| 4|
DAY ON TEST | 8| 8| 3| 5| 5| 1| 2| 3| 7| 0| 3| 9| 9| 1| 0| 5| 8| 3| 5| 7| 3| 7| 3| 8| 5|
| 6| 4| 3| 6| 6| 8| 0| 3| 2| 1| 9| 2| 7| 1| 7| 6| 5| 3| 6| 9| 3| 4| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | 4 3 4 4 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + |
Inflammation, Granulomatous | |
Lumbar, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + M + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 3 4 |
Hemorrhage | 3 |
Hyperplasia, Re Cell | 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 4 |
Inflammation, Granulomatous | 4 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 3 |
Hemorrhage | |
Hydrocephalus | 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 4| 4| 5| 7| 4| 7| 5| 4| 5| 5| 7| 4| 6| 7| 4| 6| 7| 6| 7| 6| 4|
DAY ON TEST | 8| 8| 3| 5| 5| 1| 2| 3| 7| 0| 3| 9| 9| 1| 0| 5| 8| 3| 5| 7| 3| 7| 3| 8| 5|
| 6| 4| 3| 6| 6| 8| 0| 3| 2| 1| 9| 2| 7| 1| 7| 6| 5| 3| 6| 9| 3| 4| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia | 2 |
Inflammation, Suppurative | 1|
Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus | |
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1|
Infiltration Cellular, Histiocyte | 1 2 2 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Fibrosis | 2 |
Alveolus, Inflammation, Chronic | |
Pleura, Fibrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 |
Hemorrhage | 3 3 |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 3 |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 2 2 |
Respiratory Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 3 1 1 2 4 1 3 3 2 4 1 3 2 3 2 3 3 4 3 4 4 2|
Thrombosis | |
Cortex, Necrosis | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 3 |
Renal Tubule, Hyperplasia | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Metaplasia, Squamous | 2 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 4| 7| 7| | |
DAY ON TEST | 4| 0| 3| 5| 3| 3| | |
| 6| 2| 3| 6| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 56 |
Lumen, Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 55 |
Lumen, Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 55 |
Lumen, Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 55 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 56 |
Basophilic Focus | X X | 21 |
Clear Cell Focus | | 6 |
Degeneration, Cystic | | 16 2.0|
Eosinophilic Focus | | 3 |
Hematopoietic Cell Proliferation | | 2 1.0|
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Chronic | | 1 2.0|
Mixed Cell Focus | X | 1 |
Vacuolization Cytoplasmic | 4 1 | 11 2.6|
Bile Duct, Hyperplasia | | 2 3.0|
Hepatocyte, Necrosis | | 7 1.1|
Portal, Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 10 |
Hemorrhage | | 3 4.0|
Fat, Inflammation, Granulomatous | | 1 3.0|
Fat, Necrosis | | 7 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 56 |
Acinus, Atrophy | 1 2 2 | 24 1.7|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 56 |
Acanthosis | 2 | 4 2.3|
Edema | | 1 2.0|
Inflammation, Suppurative | 2 | 5 2.0|
Ulcer | 3 | 4 3.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 56 |
Ulcer | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 4| 7| 7| | |
DAY ON TEST | 4| 0| 3| 5| 3| 3| | |
| 6| 2| 3| 6| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + | 56 |
Mineralization | | 1 1.0|
Aorta, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | 2 2 | 14 2.0|
Atrium, Thrombosis | X | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 56 |
Vacuolization Cytoplasmic | | 7 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 56 |
Hyperplasia | 3 2 | 20 2.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 56 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + | 54 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 56 |
Cyst | X | 3 |
Hemorrhage | | 1 4.0|
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 3 | 8 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 56 |
C-Cell, Hyperplasia | 1 | 10 1.4|
Follicle, Dilatation | | 1 4.0|
Follicular Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 56 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 55 |
Ectasia | 3 3 | 22 3.0|
Hyperplasia | | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 7 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 4| 7| 7| | |
DAY ON TEST | 4| 0| 3| 5| 3| 3| | |
| 6| 2| 3| 6| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2 | 9 1.9|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 56 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + | 56 |
Hemorrhage | | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
Necrosis | | 1 4.0|
Germinal Epithelium, Atrophy | | 10 4.0|
Interstitial Cell, Hyperplasia | 3 2 3 | 21 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 56 |
Hyperplasia, Re Cell | | 7 3.7|
Myelofibrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + | 12 |
Inflammation, Granulomatous | | 1 3.0|
Lumbar, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M M + + | 47 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M M + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 55 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 56 |
Hemorrhage | | 1 3.0|
Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 56 |
Fibrosis | | 7 3.3|
Hemorrhage | | 1 3.0|
Hyperplasia, Re Cell | | 4 3.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 55 |
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
Acanthosis | | 2 3.0|
Hyperkeratosis | | 1 4.0|
Inflammation, Granulomatous | | 2 3.0|
Ulcer | 2 | 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 4| 7| 7| | |
DAY ON TEST | 4| 0| 3| 5| 3| 3| | |
| 6| 2| 3| 6| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Gliosis | | 1 3.0|
Hemorrhage | | 3 2.7|
Hydrocephalus | 2 | 7 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 56 |
Foreign Body | 3 | 4 3.0|
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | 2 2 | 5 2.2|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Embolus | | 1 |
Hemorrhage | 1 1 1 | 24 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 | 10 1.7|
Alveolar Epithelium, Hyperplasia | | 3 2.3|
Alveolus, Fibrosis | | 2 2.0|
Alveolus, Inflammation, Chronic | | 4 1.3|
Pleura, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 56 |
Foreign Body | 2 2 | 10 2.0|
Hemorrhage | 3 | 6 3.0|
Inflammation, Chronic | | 2 2.0|
Inflammation, Suppurative | 2 | 4 2.5|
Goblet Cell, Respiratory Epithelium, | | |
Hypertrophy | 2 2 | 9 2.1|
Respiratory Epithelium, Hyperplasia | | 5 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 4| 7| 7| | |
DAY ON TEST | 4| 0| 3| 5| 3| 3| | |
| 6| 2| 3| 6| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 56 |
Nephropathy, Chronic | 2 2 3 2 3 4 | 52 2.5|
Thrombosis | | 1 |
Cortex, Necrosis | | 1 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 3 2.3|
Renal Tubule, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 56 |
Hemorrhage | | 2 2.5|
Metaplasia, Squamous | | 1 2.0|
Ulcer | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 6| 7| 6| 7| 7| 7| 4| 5| 4| 4| 5| 5| 7| 0| 6| 7| 5| 7| 5| 6| 5|
DAY ON TEST | 6| 3| 9| 5| 4| 3| 3| 3| 3| 3| 9| 5| 5| 5| 5| 6| 3| 5| 8| 1| 2| 3| 9| 2| 3|
| 0| 3| 3| 6| 2| 3| 7| 3| 3| 3| 6| 8| 6| 6| 5| 4| 3| 6| 8| 8| 5| 3| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A A + + + + + + + + + A + +|
Lumen, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + +|
Lumen, Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A A + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | 4 2 2 2 4 2 2|
Eosinophilic Focus | X X X X |
Granuloma, Multifocal | |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 2 2 2 3 3 |
Bile Duct, Hyperplasia | 4 |
Hepatocyte, Necrosis | 2 2 1 1|
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Granulomatous | |
Fat, Necrosis | 3 4 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 1 2 2 2 1 2 1 2 1 2 1 2|
Artery, Inflammation | |
Duct, Cyst | X|
Duct, Hyperplasia | 4|
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 |
Edema | |
Hyperkeratosis | 2 |
Inflammation, Suppurative | 3 3 |
Mineralization | |
Ulcer | 4 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 6| 7| 6| 7| 7| 7| 4| 5| 4| 4| 5| 5| 7| 0| 6| 7| 5| 7| 5| 6| 5|
DAY ON TEST | 6| 3| 9| 5| 4| 3| 3| 3| 3| 3| 9| 5| 5| 5| 5| 6| 3| 5| 8| 1| 2| 3| 9| 2| 3|
| 0| 3| 3| 6| 2| 3| 7| 3| 3| 3| 6| 8| 6| 6| 5| 4| 3| 6| 8| 8| 5| 3| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation | |
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 |
Atrium, Thrombosis | X X X |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Vacuolization Cytoplasmic | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + M + +|
Hyperplasia | 3 2 2 2 2 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + I + +|
Cyst | X X |
Hemorrhage | |
Pars Distalis, Hyperplasia | 3 3 3 3 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3|
Granuloma | |
Hyperplasia | |
Inflammation, Suppurative | 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Suppurative | 2 2 2 3 3 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 6| 7| 6| 7| 7| 7| 4| 5| 4| 4| 5| 5| 7| 0| 6| 7| 5| 7| 5| 6| 5|
DAY ON TEST | 6| 3| 9| 5| 4| 3| 3| 3| 3| 3| 9| 5| 5| 5| 5| 6| 3| 5| 8| 1| 2| 3| 9| 2| 3|
| 0| 3| 3| 6| 2| 3| 7| 3| 3| 3| 6| 8| 6| 6| 5| 4| 3| 6| 8| 8| 5| 3| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 3 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Germinal Epithelium, Atrophy | 4 4 4 4 4 4 |
Interstitial Cell, Hyperplasia | 1 3 3 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Pigmentation | |
Renal, Ectasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + + + + + + M + + + + + + M M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + M + + + + M + + + + + + M + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 3 3 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrosis | 4 4 4 4 4 2 4 |
Hyperplasia, Re Cell | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
Inflammation, Chronic | 3 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Cyst | 2 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 4 2 |
Inflammation, Chronic | 3 |
Inflammation, Granulomatous | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 6| 7| 6| 7| 7| 7| 4| 5| 4| 4| 5| 5| 7| 0| 6| 7| 5| 7| 5| 6| 5|
DAY ON TEST | 6| 3| 9| 5| 4| 3| 3| 3| 3| 3| 9| 5| 5| 5| 5| 6| 3| 5| 8| 1| 2| 3| 9| 2| 3|
| 0| 3| 3| 6| 2| 3| 7| 3| 3| 3| 6| 8| 6| 6| 5| 4| 3| 6| 8| 8| 5| 3| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Demyelination | |
Hemorrhage | 3 3 |
Hydrocephalus | 2 2 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Hyperplasia | 2 2 |
Inflammation, Suppurative | 2 2 |
Metaplasia, Squamous | 2 1 |
Mineralization | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Infiltration Cellular, Histiocyte | 1 2 1 2 3 1 3 2 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 1 3 3 3 2 |
Alveolus, Fibrosis | |
Alveolus, Mineralization | |
Alveolus, Pigmentation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 2|
Hemorrhage | |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 1 1 |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 2 3|
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Hyperplasia | 3 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 6| 7| 6| 7| 7| 7| 4| 5| 4| 4| 5| 5| 7| 0| 6| 7| 5| 7| 5| 6| 5|
DAY ON TEST | 6| 3| 9| 5| 4| 3| 3| 3| 3| 3| 9| 5| 5| 5| 5| 6| 3| 5| 8| 1| 2| 3| 9| 2| 3|
| 0| 3| 3| 6| 2| 3| 7| 3| 3| 3| 6| 8| 6| 6| 5| 4| 3| 6| 8| 8| 5| 3| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 4 2 2 2 3 2 3 4 4 3 2 1 1 1 2 3 4 3 2 3 2 3 2|
Cortex, Necrosis | 3 |
Pelvis, Dilatation | 4 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Renal Tubule, Mineralization | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Suppurative | 4 |
Mineralization | 3 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 5| 5| 4| 7| 5| 7| 5| 6| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 4| 4| 6|
DAY ON TEST | 6| 9| 4| 3| 8| 0| 8| 3| 8| 0| 2| 3| 3| 6| 2| 3| 3| 6| 3| 1| 3| 8| 5| 5| 5|
| 7| 0| 6| 3| 6| 1| 6| 9| 9| 7| 1| 1| 3| 5| 3| 3| 3| 5| 3| 7| 2| 8| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + A + + +|
Lumen, Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + A + + +|
Lumen, Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + A + + +|
Lumen, Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + A + + +|
Diverticulum | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | X X X X X X X X X X X X X|
Clear Cell Focus | X |
Degeneration, Cystic | 3 1 3 4 4 3 1 2 3 1 |
Eosinophilic Focus | X X X |
Granuloma, Multifocal | 3 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X |
Pigmentation, Hemosiderin | 3 |
Vacuolization Cytoplasmic | 2 2 1 4 |
Bile Duct, Hyperplasia | 4 |
Hepatocyte, Necrosis | 1 2 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Granulomatous | 4 |
Fat, Necrosis | 4 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 1 2 2 2 2 1 2 2 2 2 2 1 1 1|
Artery, Inflammation | 4 |
Duct, Cyst | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 |
Edema | 3 3 3 |
Hyperkeratosis | 3 |
Inflammation, Suppurative | 2 3 |
Mineralization | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 5| 5| 4| 7| 5| 7| 5| 6| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 4| 4| 6|
DAY ON TEST | 6| 9| 4| 3| 8| 0| 8| 3| 8| 0| 2| 3| 3| 6| 2| 3| 3| 6| 3| 1| 3| 8| 5| 5| 5|
| 7| 0| 6| 3| 6| 1| 6| 9| 9| 7| 1| 1| 3| 5| 3| 3| 3| 5| 3| 7| 2| 8| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + + |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + M + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation | 3 |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 |
Atrium, Thrombosis | |
Myocardium, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Vacuolization Cytoplasmic | 1 2 2 3 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 1 2 4 3 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + M M +|
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 3 3 3 |
Pars Intermedia, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3 3 3 3 3 3 |
Granuloma | |
Hyperplasia | 3 3 |
Inflammation, Suppurative | 3 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Suppurative | 4 3 2 2 |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 5| 5| 4| 7| 5| 7| 5| 6| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 4| 4| 6|
DAY ON TEST | 6| 9| 4| 3| 8| 0| 8| 3| 8| 0| 2| 3| 3| 6| 2| 3| 3| 6| 3| 1| 3| 8| 5| 5| 5|
| 7| 0| 6| 3| 6| 1| 6| 9| 9| 7| 1| 1| 3| 5| 3| 3| 3| 5| 3| 7| 2| 8| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Germinal Epithelium, Atrophy | 4 4 4 4 4 4 4 |
Interstitial Cell, Hyperplasia | 3 3 3 2 3 2 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Pigmentation | |
Renal, Ectasia | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + + + + M + + + + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + M + + + M + +|
Hemorrhage | 3 3 |
Pigmentation | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrosis | 4 3 3 2 |
Hyperplasia, Re Cell | 3 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + M + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
Inflammation, Chronic | |
Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Cyst | |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | |
Inflammation, Chronic | |
Inflammation, Granulomatous | 4 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 5| 5| 4| 7| 5| 7| 5| 6| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 4| 4| 6|
DAY ON TEST | 6| 9| 4| 3| 8| 0| 8| 3| 8| 0| 2| 3| 3| 6| 2| 3| 3| 6| 3| 1| 3| 8| 5| 5| 5|
| 7| 0| 6| 3| 6| 1| 6| 9| 9| 7| 1| 1| 3| 5| 3| 3| 3| 5| 3| 7| 2| 8| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Demyelination | 4 |
Hemorrhage | 3 1 |
Hydrocephalus | 2 2 2 2 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 3 3 |
Hyperplasia | 3 2 |
Inflammation, Suppurative | 3 |
Metaplasia, Squamous | |
Mineralization | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | 2 4 2 1 3 |
Metaplasia, Osseous | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Fibrosis | 3 |
Alveolus, Mineralization | 3 |
Alveolus, Pigmentation | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 2 2 |
Hemorrhage | 3 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 3 |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 2 3 |
Olfactory Epithelium, Metaplasia | 3 |
Respiratory Epithelium, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 5| 5| 4| 7| 5| 7| 5| 6| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 4| 4| 6|
DAY ON TEST | 6| 9| 4| 3| 8| 0| 8| 3| 8| 0| 2| 3| 3| 6| 2| 3| 3| 6| 3| 1| 3| 8| 5| 5| 5|
| 7| 0| 6| 3| 6| 1| 6| 9| 9| 7| 1| 1| 3| 5| 3| 3| 3| 5| 3| 7| 2| 8| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 PPM | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 1 3 2 4 2 2 4 4 3 1 4 2 3 2 4 3 4 4 3 2 2 2 2|
Cortex, Necrosis | |
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 2 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | |
Mineralization | |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 4| | |
DAY ON TEST | 5| 5| 6| 5| 3| 5| | |
| 9| 6| 1| 6| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
100 PPM | 6| 6| 6| 6| 6| 6| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 50 |
Lumen, Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 52 |
Lumen, Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + | 51 |
Lumen, Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 53 |
Diverticulum | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 55 |
Angiectasis | | 1 4.0|
Basophilic Focus | X X X | 28 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | | 17 2.5|
Eosinophilic Focus | | 7 |
Granuloma, Multifocal | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 4 |
Mixed Cell Focus | | 1 |
Pigmentation, Hemosiderin | | 1 3.0|
Vacuolization Cytoplasmic | 1 | 10 2.2|
Bile Duct, Hyperplasia | | 2 4.0|
Hepatocyte, Necrosis | | 8 1.8|
__________________________________________________________________________|____________|
Mesentery | | 9 |
Fat, Inflammation, Granulomatous | | 1 4.0|
Fat, Necrosis | | 7 3.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 55 |
Acinus, Atrophy | 1 1 2 | 35 1.5|
Artery, Inflammation | | 1 4.0|
Duct, Cyst | | 1 |
Duct, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 55 |
Acanthosis | | 4 2.5|
Edema | | 3 3.0|
Hyperkeratosis | | 2 2.5|
Inflammation, Suppurative | | 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 4| | |
DAY ON TEST | 5| 5| 6| 5| 3| 5| | |
| 9| 6| 1| 6| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
100 PPM | 6| 6| 6| 6| 6| 6| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 3.0|
Ulcer | | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 54 |
Mineralization | | 1 3.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 2 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + | 54 |
Aorta, Inflammation | | 1 3.0|
Aorta, Mineralization | | 2 3.5|
__________________________________________________________________________|____________|
Heart | + + + + + + | 55 |
Cardiomyopathy | 2 | 11 2.0|
Atrium, Thrombosis | | 3 |
Myocardium, Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 55 |
Hemorrhage | | 1 2.0|
Vacuolization Cytoplasmic | | 8 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 53 |
Hyperplasia | 3 | 16 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 55 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + | 49 |
Hyperplasia | | 5 2.4|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 53 |
Cyst | | 7 |
Hemorrhage | 4 | 2 4.0|
Pars Distalis, Hyperplasia | 3 | 9 3.0|
Pars Intermedia, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 55 |
C-Cell, Hyperplasia | 1 | 10 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 4| | |
DAY ON TEST | 5| 5| 6| 5| 3| 5| | |
| 9| 6| 1| 6| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
100 PPM | 6| 6| 6| 6| 6| 6| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 55 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 55 |
Ectasia | 3 | 16 3.0|
Granuloma | 4 | 1 4.0|
Hyperplasia | | 2 3.0|
Inflammation, Suppurative | | 7 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 55 |
Cyst | | 1 |
Inflammation, Suppurative | 2 | 10 2.5|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 54 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Testes | + + + + + + | 55 |
Hemorrhage | | 1 4.0|
Germinal Epithelium, Atrophy | | 13 4.0|
Interstitial Cell, Hyperplasia | 1 3 1 3 3 | 19 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 55 |
__________________________________________________________________________|____________|
Lymph Node | + + | 8 |
Lumbar, Pigmentation | 2 | 1 2.0|
Renal, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 48 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 51 |
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 55 |
Hemorrhage | | 1 4.0|
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 53 |
Hemorrhage | | 5 3.0|
Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 55 |
Developmental Malformation | | 2 |
Fibrosis | 4 2 | 13 3.4|
Hyperplasia, Re Cell | | 1 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 4| | |
DAY ON TEST | 5| 5| 6| 5| 3| 5| | |
| 9| 6| 1| 6| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
100 PPM | 6| 6| 6| 6| 6| 6| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + | 52 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 55 |
Galactocele | | 2 |
Inflammation, Chronic | | 1 3.0|
Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 55 |
Acanthosis | | 2 3.0|
Cyst | | 1 2.0|
Cyst Epithelial Inclusion | | 2 |
Hyperkeratosis | | 2 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Granulomatous | | 1 4.0|
Ulcer | | 1 4.0|
Subcutaneous Tissue, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 55 |
Developmental Malformation | | 1 |
Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 55 |
Demyelination | | 1 4.0|
Hemorrhage | 3 | 5 2.6|
Hydrocephalus | | 7 2.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | I + + + + + | 54 |
Foreign Body | | 4 3.0|
Hyperplasia | | 4 2.3|
Inflammation, Suppurative | | 3 2.3|
Metaplasia, Squamous | | 2 1.5|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + | 55 |
Hemorrhage | 1 1 1 1 1 | 37 1.0|
Infiltration Cellular, Histiocyte | 4 3 1 | 16 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 4| | |
DAY ON TEST | 5| 5| 6| 5| 3| 5| | |
| 9| 6| 1| 6| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
100 PPM | 6| 6| 6| 6| 6| 6| | L |
| 3| 4| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Metaplasia, Osseous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 7 2.1|
Alveolus, Fibrosis | | 1 3.0|
Alveolus, Mineralization | | 1 3.0|
Alveolus, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 55 |
Foreign Body | | 9 2.0|
Hemorrhage | 3 | 3 3.0|
Inflammation, Chronic | | 2 2.0|
Inflammation, Suppurative | | 4 1.8|
Goblet Cell, Respiratory Epithelium, | | |
Hypertrophy | | 4 2.5|
Olfactory Epithelium, Metaplasia | | 1 3.0|
Respiratory Epithelium, Hyperplasia | | 5 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 55 |
Nephropathy, Chronic | 2 1 2 1 3 2 | 55 2.5|
Cortex, Necrosis | | 1 3.0|
Pelvis, Dilatation | | 1 4.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 3 2.0|
Renal Tubule, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 55 |
Hemorrhage | | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
Mineralization | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 5| 5| 5| 6| 4| 4| 3| 5| 7| 4| 5| 6| 7| 4| 7| 7| 5| 7| 6| 5| 7| 6| 7| 4|
DAY ON TEST | 2| 7| 6| 2| 5| 5| 9| 7| 0| 3| 4| 6| 9| 1| 8| 3| 3| 8| 0| 4| 9| 3| 8| 3| 5|
| 2| 3| 1| 5| 3| 6| 7| 1| 7| 3| 2| 0| 8| 9| 3| 3| 3| 3| 7| 4| 7| 3| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic | 2 2 |
Eosinophilic Focus | X X X X |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | |
Vacuolization Cytoplasmic | 2 3 3 3 |
Bile Duct, Hyperplasia | 2 4 |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | |
Fat, Inflammation, Granulomatous | 4 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 1 1 2 2 2 1 2 2 2 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 2 2 |
Diverticulum | |
Edema | |
Inflammation, Suppurative | 3 4 2 |
Mineralization | |
Necrosis | 4 |
Ulcer | 3 4 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Suppurative | |
Mineralization | |
Necrosis | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 5| 5| 5| 6| 4| 4| 3| 5| 7| 4| 5| 6| 7| 4| 7| 7| 5| 7| 6| 5| 7| 6| 7| 4|
DAY ON TEST | 2| 7| 6| 2| 5| 5| 9| 7| 0| 3| 4| 6| 9| 1| 8| 3| 3| 8| 0| 4| 9| 3| 8| 3| 5|
| 2| 3| 1| 5| 3| 6| 7| 1| 7| 3| 2| 0| 8| 9| 3| 3| 3| 3| 7| 4| 7| 3| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2|
Atrium, Thrombosis | X X |
Myocardium, Mineralization | |
Myocardium, Necrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 |
Vacuolization Cytoplasmic | 1 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + I + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 3 2 2 3 3 2 2 3 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | |
Pars Distalis, Hyperplasia | 3 3 3 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X|
C-Cell, Hyperplasia | 1 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3 3 3 3 3 3 3|
Hyperplasia | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 4 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 5| 5| 5| 6| 4| 4| 3| 5| 7| 4| 5| 6| 7| 4| 7| 7| 5| 7| 6| 5| 7| 6| 7| 4|
DAY ON TEST | 2| 7| 6| 2| 5| 5| 9| 7| 0| 3| 4| 6| 9| 1| 8| 3| 3| 8| 0| 4| 9| 3| 8| 3| 5|
| 2| 3| 1| 5| 3| 6| 7| 1| 7| 3| 2| 0| 8| 9| 3| 3| 3| 3| 7| 4| 7| 3| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 4 |
Interstitial Cell, Hyperplasia | 3 4 3 2 1 3 2 3 3 1 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Lumbar, Pigmentation | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M M + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrosis | 3 4 3 4 4 4 4 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X |
Hemorrhage | |
Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | |
Inflammation, Granulomatous | 3 |
Inflammation, Suppurative | |
Ulcer | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 5| 5| 5| 6| 4| 4| 3| 5| 7| 4| 5| 6| 7| 4| 7| 7| 5| 7| 6| 5| 7| 6| 7| 4|
DAY ON TEST | 2| 7| 6| 2| 5| 5| 9| 7| 0| 3| 4| 6| 9| 1| 8| 3| 3| 8| 0| 4| 9| 3| 8| 3| 5|
| 2| 3| 1| 5| 3| 6| 7| 1| 7| 3| 2| 0| 8| 9| 3| 3| 3| 3| 7| 4| 7| 3| 4| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hydrocephalus | 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 3 |
Hyperplasia | 2 |
Inflammation, Suppurative | 2 2 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Infarct | 4 |
Infiltration Cellular, Histiocyte | 1 2 2 2 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Fibrosis | 2 2 |
Alveolus, Mineralization | |
Alveolus, Pigmentation | 2 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 |
Hemorrhage | 3 3 |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 3 |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 3 2 2 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 2 2 2 1 2 2 2 4 1 2 4 4 4 3 3 3 2 2 3 3 4 2|
Cortex, Necrosis | 4 3 3 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Hyperplasia | 4 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 7| 5| 4| 6| 6| 6| 4| 6| 6| 5| 6| 5| 7| 7| 7| 4| 7| 6| 3| 7| 6|
DAY ON TEST | 9| 6| 0| 5| 0| 9| 5| 7| 3| 0| 8| 1| 4| 3| 2| 8| 0| 0| 3| 5| 3| 6| 9| 3| 6|
| 1| 5| 7| 6| 9| 3| 6| 4| 7| 1| 0| 8| 2| 9| 9| 7| 5| 0| 3| 6| 3| 6| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + A + + + + + + + +|
Lumen, Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Lumen, Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + A + + + + + + + +|
Lumen, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 3 2 4 1 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X |
Vacuolization Cytoplasmic | 4 2 3 3 4 4 4|
Bile Duct, Hyperplasia | 3 |
Hepatocyte, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage | 4 |
Fat, Inflammation, Granulomatous | 2 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 1 1 1 2 2 2 2 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 3 1 4 4|
Diverticulum | 3 2 |
Edema | 3 |
Inflammation, Suppurative | 3 2 4 4|
Mineralization | 3 |
Necrosis | |
Ulcer | 4 4 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 3 |
Mineralization | 4 |
Necrosis | 3 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 7| 5| 4| 6| 6| 6| 4| 6| 6| 5| 6| 5| 7| 7| 7| 4| 7| 6| 3| 7| 6|
DAY ON TEST | 9| 6| 0| 5| 0| 9| 5| 7| 3| 0| 8| 1| 4| 3| 2| 8| 0| 0| 3| 5| 3| 6| 9| 3| 6|
| 1| 5| 7| 6| 9| 3| 6| 4| 7| 1| 0| 8| 2| 9| 9| 7| 5| 0| 3| 6| 3| 6| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 |
Atrium, Thrombosis | X |
Myocardium, Mineralization | 4 |
Myocardium, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
Hyperplasia | |
Vacuolization Cytoplasmic | 2 2 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 1 3 3 4 1 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X|
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3 3 3 3 3 3 3 3 |
Hyperplasia | 3 |
Inflammation, Chronic | 2 2 3 |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 1 3 2 3 3|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 7| 5| 4| 6| 6| 6| 4| 6| 6| 5| 6| 5| 7| 7| 7| 4| 7| 6| 3| 7| 6|
DAY ON TEST | 9| 6| 0| 5| 0| 9| 5| 7| 3| 0| 8| 1| 4| 3| 2| 8| 0| 0| 3| 5| 3| 6| 9| 3| 6|
| 1| 5| 7| 6| 9| 3| 6| 4| 7| 1| 0| 8| 2| 9| 9| 7| 5| 0| 3| 6| 3| 6| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 4 4 4 4 4 4 |
Interstitial Cell, Hyperplasia | 2 3 2 2 1 1 3 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Lumbar, Pigmentation | 2 2 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + M + + + + + + M M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrosis | 4 4 4 4 3 4 4 4 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
Hemorrhage | 4 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 4 |
Cyst Epithelial Inclusion | |
Hyperkeratosis | 4 |
Inflammation, Granulomatous | 3 |
Inflammation, Suppurative | 1 |
Ulcer | 4 |
Subcutaneous Tissue, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 7| 5| 4| 6| 6| 6| 4| 6| 6| 5| 6| 5| 7| 7| 7| 4| 7| 6| 3| 7| 6|
DAY ON TEST | 9| 6| 0| 5| 0| 9| 5| 7| 3| 0| 8| 1| 4| 3| 2| 8| 0| 0| 3| 5| 3| 6| 9| 3| 6|
| 1| 5| 7| 6| 9| 3| 6| 4| 7| 1| 0| 8| 2| 9| 9| 7| 5| 0| 3| 6| 3| 6| 5| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 4 4 4 3|
Hydrocephalus | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 3 3 |
Hyperplasia | |
Inflammation, Suppurative | 2 2 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Infarct | |
Infiltration Cellular, Histiocyte | 3 1 4 2 2 1 2 1 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 2 1 2 |
Alveolus, Fibrosis | 2 2 2 1 |
Alveolus, Mineralization | 4 |
Alveolus, Pigmentation | |
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 2|
Hemorrhage | |
Inflammation, Chronic | 2|
Inflammation, Suppurative | 3 2 2 1 1 |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 3 4 3 2 2 |
Respiratory Epithelium, Hyperplasia | 3 3 1 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 4 4 2 2 3 1 4 2 2 2 2 1 1 2 3 4 2 4 1 4 3 1 3 3|
Cortex, Necrosis | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Mineralization | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| | |
DAY ON TEST | 3| 8| 5| 5| 5| 7| | |
| 3| 4| 6| 6| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
200 PPM | 7| 7| 7| 7| 7| 8| | L |
| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 54 |
Lumen, Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 55 |
Lumen, Parasite Metazoan | X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 54 |
Lumen, Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 54 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 56 |
Angiectasis | | 1 4.0|
Basophilic Focus | X X X X | 32 |
Clear Cell Focus | | 2 |
Degeneration, Cystic | 1 4 | 8 2.4|
Eosinophilic Focus | X | 5 |
Hepatodiaphragmatic Nodule | X | 5 |
Mixed Cell Focus | | 1 |
Vacuolization Cytoplasmic | 2 | 12 3.1|
Bile Duct, Hyperplasia | | 3 3.0|
Hepatocyte, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 9 |
Hemorrhage | | 1 4.0|
Fat, Inflammation, Granulomatous | | 3 2.7|
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 56 |
Acinus, Atrophy | 1 2 1 2 | 29 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 56 |
Acanthosis | | 10 2.5|
Diverticulum | | 2 2.5|
Edema | | 1 3.0|
Inflammation, Suppurative | | 7 3.1|
Mineralization | | 1 3.0|
Necrosis | | 1 4.0|
Ulcer | | 7 3.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 56 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| | |
DAY ON TEST | 3| 8| 5| 5| 5| 7| | |
| 3| 4| 6| 6| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
200 PPM | 7| 7| 7| 7| 7| 8| | L |
| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 4.0|
Necrosis | | 1 3.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + | 56 |
Aorta, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | 2 | 12 2.0|
Atrium, Thrombosis | | 3 |
Myocardium, Mineralization | | 1 4.0|
Myocardium, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 56 |
Hemorrhage | | 2 2.5|
Hyperplasia | | 1 2.0|
Vacuolization Cytoplasmic | 2 4 | 10 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 53 |
Hyperplasia | 2 2 | 21 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 56 |
Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 54 |
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 56 |
Cyst | X X | 8 |
Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 3 | 9 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 56 |
Ultimobranchial Cyst | X | 2 |
C-Cell, Hyperplasia | 1 1 | 9 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 56 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| | |
DAY ON TEST | 3| 8| 5| 5| 5| 7| | |
| 3| 4| 6| 6| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
200 PPM | 7| 7| 7| 7| 7| 8| | L |
| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Ectasia | 3 3 | 25 3.0|
Hyperplasia | | 2 3.0|
Inflammation, Chronic | 2 | 4 2.3|
Inflammation, Suppurative | 3 | 6 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 56 |
Inflammation, Suppurative | 2 | 9 2.8|
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 56 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + | 56 |
Germinal Epithelium, Atrophy | | 9 4.0|
Interstitial Cell, Hyperplasia | 3 3 | 21 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 56 |
Hyperplasia, Re Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 15 |
Lumbar, Pigmentation | | 2 2.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + + + | 46 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + M | 52 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 55 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 56 |
Fibrosis | 2 | 3 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 56 |
Developmental Malformation | | 2 |
Fibrosis | 3 4 4 | 18 3.8|
Necrosis | | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 54 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 56 |
Galactocele | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| | |
DAY ON TEST | 3| 8| 5| 5| 5| 7| | |
| 3| 4| 6| 6| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
200 PPM | 7| 7| 7| 7| 7| 8| | L |
| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hemorrhage | | 1 4.0|
Epithelium, Hyperplasia | | 3 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
Acanthosis | | 3 2.7|
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | | 1 4.0|
Inflammation, Granulomatous | 3 | 3 3.0|
Inflammation, Suppurative | | 1 1.0|
Ulcer | | 1 4.0|
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Hemorrhage | | 6 3.5|
Hydrocephalus | | 7 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 56 |
Foreign Body | | 5 3.0|
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | | 4 2.0|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Hemorrhage | 1 1 1 1 1 | 34 1.0|
Infarct | | 1 4.0|
Infiltration Cellular, Histiocyte | 3 | 14 1.9|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | | 4 1.5|
Alveolus, Fibrosis | 2 | 7 1.9|
Alveolus, Mineralization | | 1 4.0|
Alveolus, Pigmentation | | 1 2.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 56 |
Foreign Body | | 7 2.0|
Hemorrhage | | 2 3.0|
Inflammation, Chronic | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| | |
DAY ON TEST | 3| 8| 5| 5| 5| 7| | |
| 3| 4| 6| 6| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
200 PPM | 7| 7| 7| 7| 7| 8| | L |
| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 6 2.0|
Goblet Cell, Respiratory Epithelium, | | |
Hypertrophy | | 8 2.6|
Respiratory Epithelium, Hyperplasia | | 6 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 56 |
Nephropathy, Chronic | 4 2 1 2 1 2 | 55 2.5|
Cortex, Necrosis | | 3 3.3|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 2.0|
Renal Tubule, Hyperplasia | | 1 4.0|
Renal Tubule, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 4| 7| 5| 6| 4| 6| 7| 7| 6| 7| 7| 7| 6| 4| 4| 7| 6| 4| 4| 4| 6| 7| 6| 6|
DAY ON TEST | 3| 5| 3| 8| 2| 5| 5| 1| 3| 9| 2| 3| 3| 2| 5| 5| 3| 7| 5| 5| 8| 6| 3| 3| 4|
| 3| 6| 3| 8| 3| 6| 0| 6| 3| 1| 7| 3| 3| 8| 6| 6| 3| 2| 6| 6| 3| 5| 3| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
Lumen, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Lumen, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 2 |
Eosinophilic Focus | X X X X X|
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X |
Thrombosis | X 2 |
Vacuolization Cytoplasmic | 3 |
Hepatocyte, Necrosis | 4 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Hemorrhage | 4 4 4 |
Fat, Inflammation, Granulomatous | 3 |
Fat, Necrosis | 2 4 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Acinus, Atrophy | 2 1 1 4 2 2 2 2 1 2 2 2 2 2 4 2|
Artery, Inflammation | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 |
Diverticulum | 3 |
Inflammation, Suppurative | |
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 4| 7| 5| 6| 4| 6| 7| 7| 6| 7| 7| 7| 6| 4| 4| 7| 6| 4| 4| 4| 6| 7| 6| 6|
DAY ON TEST | 3| 5| 3| 8| 2| 5| 5| 1| 3| 9| 2| 3| 3| 2| 5| 5| 3| 7| 5| 5| 8| 6| 3| 3| 4|
| 3| 6| 3| 8| 3| 6| 0| 6| 3| 1| 7| 3| 3| 8| 6| 6| 3| 2| 6| 6| 3| 5| 3| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 1 1 2 2 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + + + + + + + M + + + + M M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 2 3 3 4 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3 3 3|
Hyperplasia | 3|
Inflammation, Suppurative | 3 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 4 3|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 4 4 |
Interstitial Cell, Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Pigmentation | |
Lumbar, Pigmentation | 2 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hemorrhage | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + + + + + M + M + + + M + M M + +|
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 4| 7| 5| 6| 4| 6| 7| 7| 6| 7| 7| 7| 6| 4| 4| 7| 6| 4| 4| 4| 6| 7| 6| 6|
DAY ON TEST | 3| 5| 3| 8| 2| 5| 5| 1| 3| 9| 2| 3| 3| 2| 5| 5| 3| 7| 5| 5| 8| 6| 3| 3| 4|
| 3| 6| 3| 8| 3| 6| 0| 6| 3| 1| 7| 3| 3| 8| 6| 6| 3| 2| 6| 6| 3| 5| 3| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Developmental Malformation | |
Fibrosis | 3 3 3 3 4 3 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 3 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 3 3 3|
Hyperplasia | 1 |
Inflammation, Suppurative | 3 1 1 2 |
Mineralization | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | 1 1 4 3 1 |
Alveolar Epithelium, Hyperplasia | 4 3 1 3 1 |
Alveolus, Inflammation, Chronic | |
Pleura, Fibrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 |
Hemorrhage | 3 |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 4| 7| 5| 6| 4| 6| 7| 7| 6| 7| 7| 7| 6| 4| 4| 7| 6| 4| 4| 4| 6| 7| 6| 6|
DAY ON TEST | 3| 5| 3| 8| 2| 5| 5| 1| 3| 9| 2| 3| 3| 2| 5| 5| 3| 7| 5| 5| 8| 6| 3| 3| 4|
| 3| 6| 3| 8| 3| 6| 0| 6| 3| 1| 7| 3| 3| 8| 6| 6| 3| 2| 6| 6| 3| 5| 3| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | |
Nasolacrimal Duct, Inflammation | 3 |
Nasopharyngeal Duct, Hyperplasia | 2 |
Respiratory Epithelium, Hyperplasia | 3 3 2 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peritracheal Tissue, Fibrosis | 2 |
Peritracheal Tissue, Inflammation, | |
Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
__________________________________________________________________________|
Lacrimal Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 2 3 3 4 2 3 2 4 3 2 2 3 2 1 1 4 4 1 1 2 4 4 3 2|
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6|
DAY ON TEST | 3| 3| 3| 4| 3| 5| 3| 9| 8| 3| 3| 4| 6| 7| 9| 2| 3| 3| 2| 7| 3| 9| 2| 6| 5|
| 3| 3| 3| 9| 3| 6| 3| 2| 5| 3| 3| 7| 0| 9| 3| 3| 3| 3| 7| 9| 3| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Degeneration, Cystic | 2 4 2 |
Eosinophilic Focus | X X X X |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X X X X |
Thrombosis | |
Vacuolization Cytoplasmic | 1 3 2|
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + +|
Hemorrhage | 4 |
Fat, Inflammation, Granulomatous | 4 |
Fat, Necrosis | 2 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Acinus, Atrophy | 2 2 2 1 2 2 2 2 2 2 2 1|
Artery, Inflammation | 3 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Diverticulum | 4 |
Inflammation, Suppurative | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | M + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6|
DAY ON TEST | 3| 3| 3| 4| 3| 5| 3| 9| 8| 3| 3| 4| 6| 7| 9| 2| 3| 3| 2| 7| 3| 9| 2| 6| 5|
| 3| 3| 3| 9| 3| 6| 3| 2| 5| 3| 3| 7| 0| 9| 3| 3| 3| 3| 7| 9| 3| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 3 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Pars Distalis, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 4 3 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3 3 3 3 3 |
Hyperplasia | 3 3 |
Inflammation, Suppurative | 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 3 3 2 2 2 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 4 4 4 4 |
Interstitial Cell, Hyperplasia | 3 2 1 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Iliac, Pigmentation | 2 |
Lumbar, Pigmentation | |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Renal, Hemorrhage | 2 |
Renal, Pigmentation | 2|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + M + + + + M + + + + M|
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6|
DAY ON TEST | 3| 3| 3| 4| 3| 5| 3| 9| 8| 3| 3| 4| 6| 7| 9| 2| 3| 3| 2| 7| 3| 9| 2| 6| 5|
| 3| 3| 3| 9| 3| 6| 3| 2| 5| 3| 3| 7| 0| 9| 3| 3| 3| 3| 7| 9| 3| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Developmental Malformation | X X |
Fibrosis | 3 4 4 4 4 4 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hydrocephalus | 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 3 3 3 |
Hyperplasia | 1 1 |
Inflammation, Suppurative | 3 2 |
Mineralization | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | 2 1 1 2 2 |
Alveolar Epithelium, Hyperplasia | 3 3 2 2 |
Alveolus, Inflammation, Chronic | 1 2 |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 2 |
Hemorrhage | 3 3 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 1 4 3 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6|
DAY ON TEST | 3| 3| 3| 4| 3| 5| 3| 9| 8| 3| 3| 4| 6| 7| 9| 2| 3| 3| 2| 7| 3| 9| 2| 6| 5|
| 3| 3| 3| 9| 3| 6| 3| 2| 5| 3| 3| 7| 0| 9| 3| 3| 3| 3| 7| 9| 3| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Goblet Cell, Respiratory Epithelium, | |
Hypertrophy | 3 2 2 |
Nasolacrimal Duct, Inflammation | |
Nasopharyngeal Duct, Hyperplasia | |
Respiratory Epithelium, Hyperplasia | 3 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peritracheal Tissue, Fibrosis | |
Peritracheal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 3 4 4 4 2 4 2 2 3 2 2 2 3 4 3 4 4 4 2 2 2 4 2 2|
Pelvis, Dilatation | 3 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 6| 4| 5| | |
DAY ON TEST | 7| 7| 8| 9| 5| 8| | |
| 6| 2| 6| 2| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
400 PPM | 8| 8| 8| 9| 9| 9| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + | 53 |
Lumen, Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + | 54 |
Lumen, Parasite Metazoan | | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A A + + | 52 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A A + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 56 |
Basophilic Focus | X X X | 38 |
Clear Cell Focus | X | 7 |
Degeneration, Cystic | | 4 2.5|
Eosinophilic Focus | X | 10 |
Hepatodiaphragmatic Nodule | | 3 |
Mixed Cell Focus | | 5 |
Thrombosis | | 2 2.0|
Vacuolization Cytoplasmic | 3 | 5 2.4|
Hepatocyte, Necrosis | | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | | 12 |
Hemorrhage | | 4 4.0|
Fat, Inflammation, Granulomatous | | 2 3.5|
Fat, Necrosis | | 8 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 56 |
Hemorrhage | | 2 3.0|
Acinus, Atrophy | 2 2 2 | 31 2.0|
Artery, Inflammation | | 2 2.5|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 55 |
Acanthosis | 3 3 | 4 2.8|
Diverticulum | | 2 3.5|
Inflammation, Suppurative | | 1 3.0|
Ulcer | | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 55 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 6| 4| 5| | |
DAY ON TEST | 7| 7| 8| 9| 5| 8| | |
| 6| 2| 6| 2| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
400 PPM | 8| 8| 8| 9| 9| 9| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + | 56 |
__________________________________________________________________________|____________|
Heart | + + + + + + | 56 |
Cardiomyopathy | 2 | 11 2.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 56 |
Vacuolization Cytoplasmic | 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 56 |
Hyperplasia | 2 | 16 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 56 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 49 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + I + | 54 |
Cyst | X | 4 |
Pars Distalis, Hyperplasia | 3 | 10 2.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 56 |
C-Cell, Hyperplasia | 1 | 12 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 56 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 56 |
Ectasia | | 16 3.0|
Hyperplasia | | 3 3.0|
Inflammation, Suppurative | 3 | 8 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 56 |
Inflammation, Suppurative | 3 | 12 2.4|
Epithelium, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 56 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + | 56 |
Germinal Epithelium, Atrophy | 4 | 9 4.0|
Interstitial Cell, Hyperplasia | 3 2 | 9 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 6| 4| 5| | |
DAY ON TEST | 7| 7| 8| 9| 5| 8| | |
| 6| 2| 6| 2| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
400 PPM | 8| 8| 8| 9| 9| 9| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | + | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 56 |
__________________________________________________________________________|____________|
Lymph Node | + | 13 |
Iliac, Pigmentation | | 1 2.0|
Lumbar, Pigmentation | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hemorrhage | | 1 2.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M + | 45 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 54 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 56 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 56 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 56 |
Congestion | | 1 3.0|
Developmental Malformation | | 2 |
Fibrosis | 3 | 15 3.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 56 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 56 |
Cyst Epithelial Inclusion | | 1 |
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 56 |
Hemorrhage | | 4 1.8|
Hydrocephalus | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05133-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ACETONITRILE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:32:11
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 6| 4| 5| | |
DAY ON TEST | 7| 7| 8| 9| 5| 8| | |
| 6| 2| 6| 2| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
400 PPM | 8| 8| 8| 9| 9| 9| | L |
| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | 3 | 9 3.0|
Hyperplasia | 2 | 4 1.3|
Inflammation, Suppurative | 3 3 | 8 2.3|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + | 56 |
Hemorrhage | 1 1 1 | 35 1.0|
Infiltration Cellular, Histiocyte | 1 | 11 1.7|
Alveolar Epithelium, Hyperplasia | 2 | 10 2.4|
Alveolus, Inflammation, Chronic | | 2 1.5|
Pleura, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 56 |
Foreign Body | | 7 2.0|
Hemorrhage | 3 3 | 5 3.0|
Inflammation, Chronic | | 2 2.0|
Inflammation, Suppurative | | 10 2.3|
Goblet Cell, Respiratory Epithelium, | | |
Hypertrophy | | 3 2.3|
Nasolacrimal Duct, Inflammation | | 1 3.0|
Nasopharyngeal Duct, Hyperplasia | | 1 2.0|
Respiratory Epithelium, Hyperplasia | | 8 2.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 56 |
Peritracheal Tissue, Fibrosis | | 1 2.0|
Peritracheal Tissue, Inflammation, | | |
Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 56 |
Nephropathy, Chronic | 1 3 2 2 1 2 | 56 2.7|
Pelvis, Dilatation | | 1 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 56 |
Transitional Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
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