TDMS Study 05133-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest ACETONITRILE DATE: 05/20/95
EXPERIMENT: 05133 TEST: 03 TIME: 06:28:15
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES55073 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 242
PATHOLOGIST: R. RENNE CAS: 75-05-8
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest ACETONITRILE DATE: 05/20/95
EXPERIMENT: 05133 TEST: 03 TIME: 06:28:15
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES55073 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 242
PATHOLOGIST: R. RENNE CAS: 75-05-8
ACETONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 37 CENSORED DEATHS 8 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 394 418 472 483 492 511 520 524 539 546 |
| 561 566 587 597 602 609 623 632 637 646 |
| 651 651 652 674 679 679 684 684 685 685 |
| 686 693 699 701 707 721 729 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 55 UNCENSORED DEATHS 34 CENSORED DEATHS 8 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 331 446 496 517 525 530 555 558 559 560 |
| 561 564 567 586 586 588 590 595 623 637 |
| 639 642 653 665 665 688 689 693 701 707 |
| 718 721 723 732 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 39 CENSORED DEATHS 8 TERMINAL 9 |
| |
| UNCENSORED DEATHS |
| 371 395 442 480 483 497 507 525 539 560 |
| 561 573 583 587 593 597 601 618 622 629 |
| 637 642 644 653 660 665 666 673 674 684 |
| 684 691 698 700 705 707 707 709 719 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 |
| |
==================================================================================
ACETONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 31 CENSORED DEATHS 8 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 483 485 547 560 567 576 586 588 588 597 |
| 623 628 632 641 649 650 652 665 672 672 |
| 679 679 691 692 692 693 716 723 727 727 |
| 727 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 |
| |
==================================================================================
ACETONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 96.4 92.2 81.8 69.2 52.4 23.1 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 98.2 98.2 96.4 87.8 62.1 47.1 27.8 |
| | |
| | |
|200 PPM | 100.0 100.0 100.0 100.0 96.4 90.4 82.0 65.2 46.3 18.9 |
| | |
| | |
|400 PPM | 100.0 100.0 100.0 100.0 100.0 95.8 95.8 79.2 62.5 35.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 100 PPM 200 PPM 400 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 23.1% 27.8% 18.9% 35.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.141N P=0.746N P=0.667 P=0.137N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 611.3 606.2 607.2 638.9 |
|NATURAL DEATHS (C) | (14.5) (15.2) (14.5) (12.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 613.0 614.3 605.8 641.4 |
|(STANDARD ERROR) | (14.4) (14.7) (14.4) (13.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ACETONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 24 CENSORED DEATHS 9 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 105 310 360 377 427 470 525 530 588 597 |
| 623 625 637 662 665 702 706 707 714 721 |
| 721 721 727 729 |
| CENSORED DEATHS |
| 331 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 27 CENSORED DEATHS 8 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 328 478 506 517 588 600 603 614 621 623 |
| 623 637 651 665 665 671 679 693 693 698 |
| 706 707 713 713 718 719 721 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 22 CENSORED DEATHS 8 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 292 376 469 485 534 555 566 566 567 588 |
| 597 623 625 651 651 665 671 671 685 693 |
| 719 727 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 |
| |
==================================================================================
ACETONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 56 UNCENSORED DEATHS 19 CENSORED DEATHS 8 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 394 427 558 572 599 618 629 666 670 672 |
| 672 679 679 679 693 707 721 723 729 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 |
| |
==================================================================================
ACETONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.2 98.2 94.6 92.8 88.8 84.5 80.1 69.3 49.8 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 98.2 98.2 96.1 91.9 85.7 69.0 43.9 |
| | |
| | |
|200 PPM | 100.0 100.0 100.0 98.2 96.4 92.2 90.1 77.6 67.1 54.5 |
| | |
| | |
|400 PPM | 100.0 100.0 100.0 100.0 98.2 96.4 96.4 90.1 85.9 60.8 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 100 PPM 200 PPM 400 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 49.8% 43.9% 54.5% 60.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.166N P=0.752 P=0.843N P=0.290N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 581.2 635.2 589.8 636.2 |
|NATURAL DEATHS (C) | (33.5) (17.5) (23.3) (21.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 621.8 646.8 637.8 661.2 |
|(STANDARD ERROR) | (20.1) (14.7) (16.1) (14.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ACETONITRILE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
100 PPM = 2
200 PPM = 3
400 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1 4
| 2 3 1 1 2 1442
| 3 1142 2 44
| 1 1 2 2 44
90 + 3 1 1 22 4 4
| 3 1 12 2 44
| 3 1 1
| 11 3 4 4
80 + 1 21 4 4
| 33 44
P | 13 1 44
E | 2 1 31 44
R 70 + 311 44
C | 2 2 1 1 44
E | 3 1 1 4 4
N | 2 2 44
T 60 + 231 1
| 22 44
S | 11 4 4
U | 2 1 2 1
R 50 + 3 3
V | 23 2
I | 3114 44
V |
A 40 + 332 2
L | 2 2
| 11 4 4
| 111 22
30 + 33 2 2
| 1 1 2
| 1 1
| 33 1
20 + 33 3
|
|
|
10 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 43 obs hidden.
ACETONITRILE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
100 PPM = 2
200 PPM = 3
400 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2 4
| 1 3 1 2 1 3 4 4 3 2 4
| 1 1 3 23 22 4 4
| 1 1 3 2 3 4 2 4
P 90 + 1 1 1 3 3 2 2 4
E | 11 33 22 44
R | 1 1 22 4 4
C | 3 1 1 22
E 80 + 3 1 1
N | 3 112 44
T | 311 2
| 31 2 1 4 4
S 70 + 3 12 4 1
U | 322 4 4
R | 2 2 44
V | 3 3 11 4 4
I 60 + 322 11 4
V | 322 33
A | 2211 3
L | 1 1
50 + 22 1
|
| 2 2
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 24 obs hidden.