TDMS Study 05134-02 Pathology Tables
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
Facility: Battelle Northwest
Chemical CAS #: 106-99-0
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 6| 2| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 5| 5| 3| 8| 3| 3| 3| 3| 2| 8| 3| 3| 5| 3|
| 7| 7| 7| 7| 7| 7| 7| 8| 2| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X X X X|
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Lymphoma Malignant Lymphocytic | |
Fat, Lymphoma Malignant Mixed | |
Fat, Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | |
Acinus, Histiocytic Sarcoma | |
Acinus, Lymphoma Malignant | |
Lymphocytic | |
Acinus, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 6| 2| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 5| 5| 3| 8| 3| 3| 3| 3| 2| 8| 3| 3| 5| 3|
| 7| 7| 7| 7| 7| 7| 7| 8| 2| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + M M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M |
__________________________________________________________________________|
Ovary | + + + + + I + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Granulosa Cell Tumor Benign | X|
Hemangioma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Thecoma Benign | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | X |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Iliac, Lymphoma Malignant Lymphocytic| |
Iliac, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 6| 2| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 5| 5| 3| 8| 3| 3| 3| 3| 2| 8| 3| 3| 5| 3|
| 7| 7| 7| 7| 7| 7| 7| 8| 2| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + + M M + + + + + M + + + + + M +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + M + M + + + + + + + + M M M + + + M +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + M M I + M M M M + + M M + + + + + M + M +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Hemangiosarcoma, Metastatic, Spleen | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 6| 2| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 5| 5| 3| 8| 3| 3| 3| 3| 2| 8| 3| 3| 5| 3|
| 7| 7| 7| 7| 7| 7| 7| 8| 2| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Sarcoma, Metastatic, | |
Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + I + + + + + + + + + + + M + + + +|
Adenoma | X X X X X X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 5| 7| 4| 7| 7| 2| 7| 7| 4| 4| 7| 7| 4| 4| 7| 7| 2| 7|
DAY ON TEST | 7| 3| 3| 1| 5| 3| 3| 6| 3| 5| 3| 3| 8| 3| 3| 5| 5| 3| 3| 5| 5| 3| 3| 8| 0|
| 7| 7| 7| 4| 1| 7| 7| 0| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + M M + M + + + + + + + + M + + + M + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + A + + + I + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X X|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Lymphoma Malignant Lymphocytic | |
Fat, Lymphoma Malignant Mixed | |
Fat, Sarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | X |
Acinus, Histiocytic Sarcoma | X|
Acinus, Lymphoma Malignant | |
Lymphocytic | |
Acinus, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 5| 7| 4| 7| 7| 2| 7| 7| 4| 4| 7| 7| 4| 4| 7| 7| 2| 7|
DAY ON TEST | 7| 3| 3| 1| 5| 3| 3| 6| 3| 5| 3| 3| 8| 3| 3| 5| 5| 3| 3| 5| 5| 3| 3| 8| 0|
| 7| 7| 7| 4| 1| 7| 7| 0| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M M + + + + + + + + I M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Granulosa Cell Tumor Benign | |
Hemangioma | X |
Histiocytic Sarcoma | X|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Thecoma Benign | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Iliac, Lymphoma Malignant Lymphocytic| |
Iliac, Lymphoma Malignant Mixed | |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 5| 7| 4| 7| 7| 2| 7| 7| 4| 4| 7| 7| 4| 4| 7| 7| 2| 7|
DAY ON TEST | 7| 3| 3| 1| 5| 3| 3| 6| 3| 5| 3| 3| 8| 3| 3| 5| 5| 3| 3| 5| 5| 3| 3| 8| 0|
| 7| 7| 7| 4| 1| 7| 7| 0| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | M M + + + + + + + M + + + + M + + + + + + + + + +|
Histiocytic Sarcoma | X|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + M + + + + + + + + M + + + + + + + I +|
Histiocytic Sarcoma | X|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M M + + + + M M + M M + + M M + M + + M + M +|
Histiocytic Sarcoma | X|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | X|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Hemangiosarcoma, Metastatic, Spleen | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Histiocytic Sarcoma | X|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 5| 7| 4| 7| 7| 2| 7| 7| 4| 4| 7| 7| 4| 4| 7| 7| 2| 7|
DAY ON TEST | 7| 3| 3| 1| 5| 3| 3| 6| 3| 5| 3| 3| 8| 3| 3| 5| 5| 3| 3| 5| 5| 3| 3| 8| 0|
| 7| 7| 7| 4| 1| 7| 7| 0| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Sarcoma, Metastatic, | |
Skin | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + M + + M +|
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + I + + + + A + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 7| 2| 2| 7| 2| 6| 7| 4| 2| 2| 7| 7| 4| 6| | |
DAY ON TEST | 3| 2| 3| 3| 5| 3| 3| 8| 8| 3| 8| 4| 3| 0| 8| 8| 3| 0| 8| 5| | |
| 7| 3| 7| 7| 7| 7| 7| 2| 2| 7| 2| 4| 7| 1| 2| 2| 7| 8| 5| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + + + + + + + + + + M + | 61 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + M + + | 66 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + | 67 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 69 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X X | 4 |
Hepatocellular Adenoma | X | 11 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | X | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Mesentery | + + | 12 |
Fat, Lymphoma Malignant Lymphocytic | X | 1 |
Fat, Lymphoma Malignant Mixed | X | 1 |
Fat, Sarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 |
Sarcoma, Metastatic, Skin | | 1 |
Acinus, Histiocytic Sarcoma | X | 2 |
Acinus, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Acinus, Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Leiomyoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 69 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 7| 2| 2| 7| 2| 6| 7| 4| 2| 2| 7| 7| 4| 6| | |
DAY ON TEST | 3| 2| 3| 3| 5| 3| 3| 8| 8| 3| 8| 4| 3| 0| 8| 8| 3| 0| 8| 5| | |
| 7| 3| 7| 7| 7| 7| 7| 2| 2| 7| 2| 4| 7| 1| 2| 2| 7| 8| 5| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | X | 2 |
Capsule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M M + + M + M + + + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | | 1 |
Pars Distalis, Adenoma | X X | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 69 |
Adenoma | X | 2 |
Granulosa Cell Tumor Benign | | 1 |
Hemangioma | | 1 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Thecoma Benign | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangioma | | 1 |
Polyp Stromal | X | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 7| 2| 2| 7| 2| 6| 7| 4| 2| 2| 7| 7| 4| 6| | |
DAY ON TEST | 3| 2| 3| 3| 5| 3| 3| 8| 8| 3| 8| 4| 3| 0| 8| 8| 3| 0| 8| 5| | |
| 7| 3| 7| 7| 7| 7| 7| 2| 2| 7| 2| 4| 7| 1| 2| 2| 7| 8| 5| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Iliac, Lymphoma Malignant Lymphocytic| X | 1 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Pancreatic, Lymphoma Malignant Mixed | X | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + + + + + + + M M + + + + + | 58 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + I M M + M M + + + + + | 53 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M M + M + M M M + + + + + + M + + + | 39 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 69 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 69 |
Hemangiosarcoma | | 2 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Thymus | + A + + + + + + + + + M + + + + + + + + | 66 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + | 69 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 7| 2| 2| 7| 2| 6| 7| 4| 2| 2| 7| 7| 4| 6| | |
DAY ON TEST | 3| 2| 3| 3| 5| 3| 3| 8| 8| 3| 8| 4| 3| 0| 8| 8| 3| 0| 8| 5| | |
| 7| 3| 7| 7| 7| 7| 7| 2| 2| 7| 2| 4| 7| 1| 2| 2| 7| 8| 5| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Alveolar/Bronchiolar Adenoma | X | 4 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Mediastinum, Sarcoma, Metastatic, | | |
Skin | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + I + + + + + + M + + + + | 64 |
Adenoma | X X | 10 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 69 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 67 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | X | 3 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 2| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 5| 7| 4| 2| 0| 7|
DAY ON TEST | 5| 3| 3| 7| 8| 3| 2| 3| 5| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 2| 3| 5| 8| 0| 3|
| 7| 5| 5| 2| 2| 5| 2| 5| 7| 5| 5| 7| 5| 2| 5| 2| 5| 5| 5| 4| 5| 7| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.25 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + M + + + + + + M + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + A A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + A A|
Adenoma | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + M +|
Carcinoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + A +|
Carcinoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + A +|
Hepatocellular Carcinoma | |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Lymphoma Malignant Lymphocytic | |
Fat, Sarcoma, Metastatic, Uterus | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A +|
Acinus, Lymphoma Malignant | |
Lymphocytic | |
Acinus, Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Lung | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 2| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 5| 7| 4| 2| 0| 7|
DAY ON TEST | 5| 3| 3| 7| 8| 3| 2| 3| 5| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 2| 3| 5| 8| 0| 3|
| 7| 5| 5| 2| 2| 5| 2| 5| 7| 5| 5| 7| 5| 2| 5| 2| 5| 5| 5| 4| 5| 7| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.25 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + A +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + A I|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + + + M M + + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + A +|
Pars Distalis, Adenoma | X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M +|
Lymphoma Malignant Lymphocytic | |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + A +|
Adenoma | X |
Granular Cell Tumor Benign | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + A +|
Adenocarcinoma | |
Hemangioma | X |
Leiomyosarcoma | |
Lymphoma Malignant Lymphocytic | |
Polyp Stromal | X X|
Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + A +|
Hemangioma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Iliac, Lymphoma Malignant Lymphocytic| |
Iliac, Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 2| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 5| 7| 4| 2| 0| 7|
DAY ON TEST | 5| 3| 3| 7| 8| 3| 2| 3| 5| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 2| 3| 5| 8| 0| 3|
| 7| 5| 5| 2| 2| 5| 2| 5| 7| 5| 5| 7| 5| 2| 5| 2| 5| 5| 5| 4| 5| 7| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.25 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Histiocytic Sarcoma | |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + M + + + + + + + + M +|
Adenocarcinoma, Metastatic, Lung | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M M + + + + M + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + M M + + M + + M + M + + + M +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + I + + + + + + + + M +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A +|
Hemangioma | X |
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + M + + + + + + + + + + +|
Adenoacanthoma | X |
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Harderian Gland | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 2| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 5| 7| 4| 2| 0| 7|
DAY ON TEST | 5| 3| 3| 7| 8| 3| 2| 3| 5| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 2| 3| 5| 8| 0| 3|
| 7| 5| 5| 2| 2| 5| 2| 5| 7| 5| 5| 7| 5| 2| 5| 2| 5| 5| 5| 4| 5| 7| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.25 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenocarcinoma, Multiple | |
Adenocarcinoma, Metastatic, | |
Harderian Gland | X |
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Adenocarcinoma, Metastatic, Uterus | |
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Mediastinum, Adenocarcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + M +|
Adenocarcinoma | X |
Adenoma | X X X X X X |
Bilateral, Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A +|
Adenocarcinoma, Metastatic, Lung | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + M + + + A +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 2| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 5| 7| 4| 2| 0| 7|
DAY ON TEST | 5| 3| 3| 7| 8| 3| 2| 3| 5| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 2| 3| 5| 8| 0| 3|
| 7| 5| 5| 2| 2| 5| 2| 5| 7| 5| 5| 7| 5| 2| 5| 2| 5| 5| 5| 4| 5| 7| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.25 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Mixed | X X X X X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 4| 2| 2| 6| 7| 2| 7| 7| 6| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 5| 3| 6| 8| 8| 5| 3| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 5| 5| 3| 3| 9|
| 9| 5| 5| 7| 5| 7| 2| 2| 3| 5| 2| 5| 5| 2| 6| 6| 8| 6| 7| 6| 7| 7| 6| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
6.25 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + M M +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + I + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X|
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Lymphoma Malignant Lymphocytic | X |
Fat, Sarcoma, Metastatic, Uterus | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Acinus, Lymphoma Malignant | |
Lymphocytic | |
Acinus, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Lung | X|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 4| 2| 2| 6| 7| 2| 7| 7| 6| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 5| 3| 6| 8| 8| 5| 3| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 5| 5| 3| 3| 9|
| 9| 5| 5| 7| 5| 7| 2| 2| 3| 5| 2| 5| 5| 2| 6| 6| 8| 6| 7| 6| 7| 7| 6| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
6.25 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Granular Cell Tumor Benign | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Hemangioma | |
Leiomyosarcoma | |
Lymphoma Malignant Lymphocytic | X |
Polyp Stromal | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Iliac, Lymphoma Malignant Lymphocytic| |
Iliac, Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 4| 2| 2| 6| 7| 2| 7| 7| 6| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 5| 3| 6| 8| 8| 5| 3| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 5| 5| 3| 3| 9|
| 9| 5| 5| 7| 5| 7| 2| 2| 3| 5| 2| 5| 5| 2| 6| 6| 8| 6| 7| 6| 7| 7| 6| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
6.25 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Histiocytic Sarcoma | |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + + I + + + + + + +|
Adenocarcinoma, Metastatic, Lung | X|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M M + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M M + + M M M + M + + M M + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + I + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + M|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + +|
Adenoacanthoma | |
Adenocarcinoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Harderian Gland | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 4| 2| 2| 6| 7| 2| 7| 7| 6| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 5| 3| 6| 8| 8| 5| 3| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 5| 5| 3| 3| 9|
| 9| 5| 5| 7| 5| 7| 2| 2| 3| 5| 2| 5| 5| 2| 6| 6| 8| 6| 7| 6| 7| 7| 6| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
6.25 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Adenocarcinoma, Multiple | X|
Adenocarcinoma, Metastatic, | |
Harderian Gland | |
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Adenocarcinoma, Metastatic, Uterus | X |
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Mediastinum, Adenocarcinoma, | |
Metastatic, Lung | X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenoma | X X |
Bilateral, Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Lung | X|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + M + M + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 4| 2| 2| 6| 7| 2| 7| 7| 6| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 5| 3| 6| 8| 8| 5| 3| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 5| 5| 3| 3| 9|
| 9| 5| 5| 7| 5| 7| 2| 2| 3| 5| 2| 5| 5| 2| 6| 6| 8| 6| 7| 6| 7| 7| 6| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
6.25 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 2| 6| 6| 7| 7| 2| 7| 7| 6| 6| 7| 4| 7| 2| 2| 7| 7| | |
DAY ON TEST | 5| 3| 3| 8| 9| 7| 3| 3| 8| 3| 3| 4| 4| 3| 5| 3| 8| 8| 3| 3| | |
| 7| 6| 6| 2| 5| 3| 6| 6| 2| 0| 6| 4| 1| 6| 7| 6| 2| 2| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
6.25 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + M + + M | 41 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + M + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + | 45 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + A + + + + | 46 |
Carcinoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + A + + + + | 45 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 52 |
Hepatocellular Carcinoma | X X X | 5 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X X | 10 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 5 |
__________________________________________________________________________|____________|
Mesentery | + + + + + | 13 |
Fat, Lymphoma Malignant Lymphocytic | X X | 3 |
Fat, Sarcoma, Metastatic, Uterus | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 49 |
Acinus, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Acinus, Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + A + + + + | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Tooth | | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 2| 6| 6| 7| 7| 2| 7| 7| 6| 6| 7| 4| 7| 2| 2| 7| 7| | |
DAY ON TEST | 5| 3| 3| 8| 9| 7| 3| 3| 8| 3| 3| 4| 4| 3| 5| 3| 8| 8| 3| 3| | |
| 7| 6| 6| 2| 5| 3| 6| 6| 2| 0| 6| 4| 1| 6| 7| 6| 2| 2| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
6.25 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 50 |
Adenocarcinoma, Metastatic, Lung | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 49 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + M + M + + + + M | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + | 49 |
Pars Distalis, Adenoma | X X | 12 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + | 59 |
Adenoma | X X | 4 |
Granular Cell Tumor Benign | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 50 |
Adenocarcinoma | | 1 |
Hemangioma | | 1 |
Leiomyosarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Polyp Stromal | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 2| 6| 6| 7| 7| 2| 7| 7| 6| 6| 7| 4| 7| 2| 2| 7| 7| | |
DAY ON TEST | 5| 3| 3| 8| 9| 7| 3| 3| 8| 3| 3| 4| 4| 3| 5| 3| 8| 8| 3| 3| | |
| 7| 6| 6| 2| 5| 3| 6| 6| 2| 0| 6| 4| 1| 6| 7| 6| 2| 2| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
6.25 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 49 |
Hemangioma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 50 |
Iliac, Lymphoma Malignant Lymphocytic| X | 1 |
Iliac, Lymphoma Malignant Mixed | | 2 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Histiocytic Sarcoma | X | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
Renal, Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + + + + + + M + + + | 42 |
Adenocarcinoma, Metastatic, Lung | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + + + M + + + + + | 42 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + M + + M M + M + + M | 29 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + | 46 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 49 |
Hemangioma | | 1 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X | 7 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + | 46 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 2| 6| 6| 7| 7| 2| 7| 7| 6| 6| 7| 4| 7| 2| 2| 7| 7| | |
DAY ON TEST | 5| 3| 3| 8| 9| 7| 3| 3| 8| 3| 3| 4| 4| 3| 5| 3| 8| 8| 3| 3| | |
| 7| 6| 6| 2| 5| 3| 6| 6| 2| 0| 6| 4| 1| 6| 7| 6| 2| 2| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
6.25 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + + + + + + | 46 |
Adenoacanthoma | | 1 |
Adenocarcinoma | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 50 |
Subcutaneous Tissue, Hemangiosarcoma | | 2 |
Subcutaneous Tissue, Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 50 |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + | 60 |
Adenocarcinoma | | 1 |
Adenocarcinoma, Multiple | | 1 |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | | 1 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | X | 1 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Alveolar/Bronchiolar Adenoma | X X X | 11 |
Alveolar/Bronchiolar Carcinoma | X | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X | 2 |
Mediastinum, Adenocarcinoma, | | |
Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 2| 6| 6| 7| 7| 2| 7| 7| 6| 6| 7| 4| 7| 2| 2| 7| 7| | |
DAY ON TEST | 5| 3| 3| 8| 9| 7| 3| 3| 8| 3| 3| 4| 4| 3| 5| 3| 8| 8| 3| 3| | |
| 7| 6| 6| 2| 5| 3| 6| 6| 2| 0| 6| 4| 1| 6| 7| 6| 2| 2| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
6.25 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + | 50 |
Adenocarcinoma | | 1 |
Adenoma | X X | 10 |
Bilateral, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 49 |
Adenocarcinoma, Metastatic, Lung | | 1 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 46 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + | 60 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 1| 4| 4| 6| 7| 2| 6| 7| 4| 2| 2| 6| 4| 5| 7| 7| 6| 5| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 4| 9| 5| 5| 7| 3| 8| 8| 3| 5| 8| 8| 9| 5| 0| 3| 3| 5| 3| 5| 3| 9| 3| 5|
| 4| 5| 4| 7| 7| 7| 4| 2| 1| 4| 7| 2| 2| 7| 7| 7| 4| 4| 0| 3| 7| 4| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + A + + A + + A + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + A + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Parathyroid | |
Gland | |
Hepatocellular Carcinoma | X X X|
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Histiocytic Sarcoma | |
Fat, Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + +|
Acinus, Lymphoma Malignant | |
Lymphocytic | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Pericardium, Leiomyosarcoma, | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 1| 4| 4| 6| 7| 2| 6| 7| 4| 2| 2| 6| 4| 5| 7| 7| 6| 5| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 4| 9| 5| 5| 7| 3| 8| 8| 3| 5| 8| 8| 9| 5| 0| 3| 3| 5| 3| 5| 3| 9| 3| 5|
| 4| 5| 4| 7| 7| 7| 4| 2| 1| 4| 7| 2| 2| 7| 7| 7| 4| 4| 0| 3| 7| 4| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Metastatic, Uterus | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + A + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + A + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + M A + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + M + M M + + + + + M M M|
Carcinoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + + + +|
Carcinoma, Metastatic, Parathyroid | |
Gland | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Granulosa Cell Tumor Benign | X |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leiomyosarcoma | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Iliac, Histiocytic Sarcoma | X |
Iliac, Lymphoma Malignant Lymphocytic| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 1| 4| 4| 6| 7| 2| 6| 7| 4| 2| 2| 6| 4| 5| 7| 7| 6| 5| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 4| 9| 5| 5| 7| 3| 8| 8| 3| 5| 8| 8| 9| 5| 0| 3| 3| 5| 3| 5| 3| 9| 3| 5|
| 4| 5| 4| 7| 7| 7| 4| 2| 1| 4| 7| 2| 2| 7| 7| 7| 4| 4| 0| 3| 7| 4| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Histiocytic Sarcoma | X X |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + M + + + + + + M M + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M M +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + A + + + M + M + M M M + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + A + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + M + M + + + + + + + + + M +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Adenoacanthoma | |
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangioma | |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 1| 4| 4| 6| 7| 2| 6| 7| 4| 2| 2| 6| 4| 5| 7| 7| 6| 5| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 4| 9| 5| 5| 7| 3| 8| 8| 3| 5| 8| 8| 9| 5| 0| 3| 3| 5| 3| 5| 3| 9| 3| 5|
| 4| 5| 4| 7| 7| 7| 4| 2| 1| 4| 7| 2| 2| 7| 7| 7| 4| 4| 0| 3| 7| 4| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Adenocarcinoma, Metastatic, Lung | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X |
Adenocarcinoma, Metastatic, | |
Harderian Gland | |
Alveolar/Bronchiolar Adenoma | X X X X|
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X X X |
Carcinoma, Metastatic, Parathyroid | |
Gland | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
Fat, Mediastinum, Hemangioma | |
Mediastinum, Adenocarcinoma, | |
Metastatic, Lung | X X |
Mediastinum, Hemangiosarcoma, | |
Metastatic, Skin | |
Mediastinum, Hepatocellular | |
Carcinoma, Metastatic, Liver | X |
Mediastinum, Leiomyosarcoma, | |
Metastatic, Uterus | |
__________________________________________________________________________|
Nose | + + + A + + + + A + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + A + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | A |
__________________________________________________________________________|
Eye | M |
__________________________________________________________________________|
Harderian Gland | + + M + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 1| 4| 4| 6| 7| 2| 6| 7| 4| 2| 2| 6| 4| 5| 7| 7| 6| 5| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 4| 9| 5| 5| 7| 3| 8| 8| 3| 5| 8| 8| 9| 5| 0| 3| 3| 5| 3| 5| 3| 9| 3| 5|
| 4| 5| 4| 7| 7| 7| 4| 2| 1| 4| 7| 2| 2| 7| 7| 7| 4| 4| 0| 3| 7| 4| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + A + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Lung | X |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Carcinoma, Metastatic, Parathyroid | |
Gland | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 7| 4| 7| 7| 2| 4| 5| 5| 5| 4| 3| 2| 2| 2| 6| 2| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 5| 5| 6| 3| 5| 3| 3| 8| 5| 4| 7| 4| 9| 6| 8| 8| 8| 0| 8| 3| 8| 3| 7| 3|
| 4| 7| 7| 9| 4| 7| 4| 4| 2| 7| 1| 3| 1| 2| 5| 2| 2| 2| 0| 2| 4| 1| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + A A + + + + + A +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A A + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Parathyroid | |
Gland | X |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Histiocytic Sarcoma | X |
Fat, Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + +|
Acinus, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Pericardium, Leiomyosarcoma, | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 7| 4| 7| 7| 2| 4| 5| 5| 5| 4| 3| 2| 2| 2| 6| 2| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 5| 5| 6| 3| 5| 3| 3| 8| 5| 4| 7| 4| 9| 6| 8| 8| 8| 0| 8| 3| 8| 3| 7| 3|
| 4| 7| 7| 9| 4| 7| 4| 4| 2| 7| 1| 3| 1| 2| 5| 2| 2| 2| 0| 2| 4| 1| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Metastatic, Uterus | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + + + M + + + M +|
Carcinoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Parathyroid | |
Gland | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Granulosa Cell Tumor Benign | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leiomyosarcoma | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | X |
Iliac, Histiocytic Sarcoma | |
Iliac, Lymphoma Malignant Lymphocytic| X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 7| 4| 7| 7| 2| 4| 5| 5| 5| 4| 3| 2| 2| 2| 6| 2| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 5| 5| 6| 3| 5| 3| 3| 8| 5| 4| 7| 4| 9| 6| 8| 8| 8| 0| 8| 3| 8| 3| 7| 3|
| 4| 7| 7| 9| 4| 7| 4| 4| 2| 7| 1| 3| 1| 2| 5| 2| 2| 2| 0| 2| 4| 1| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Histiocytic Sarcoma | |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + + + M + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Adenoacanthoma | X |
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangioma | |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, | |
Neurofibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 7| 4| 7| 7| 2| 4| 5| 5| 5| 4| 3| 2| 2| 2| 6| 2| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 5| 5| 6| 3| 5| 3| 3| 8| 5| 4| 7| 4| 9| 6| 8| 8| 8| 0| 8| 3| 8| 3| 7| 3|
| 4| 7| 7| 9| 4| 7| 4| 4| 2| 7| 1| 3| 1| 2| 5| 2| 2| 2| 0| 2| 4| 1| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Adenocarcinoma, Metastatic, Lung | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenocarcinoma, Metastatic, | |
Harderian Gland | X |
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Parathyroid | |
Gland | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
Fat, Mediastinum, Hemangioma | |
Mediastinum, Adenocarcinoma, | |
Metastatic, Lung | |
Mediastinum, Hemangiosarcoma, | |
Metastatic, Skin | X |
Mediastinum, Hepatocellular | |
Carcinoma, Metastatic, Liver | |
Mediastinum, Leiomyosarcoma, | |
Metastatic, Uterus | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Adenoma | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 7| 4| 7| 7| 2| 4| 5| 5| 5| 4| 3| 2| 2| 2| 6| 2| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 5| 5| 6| 3| 5| 3| 3| 8| 5| 4| 7| 4| 9| 6| 8| 8| 8| 0| 8| 3| 8| 3| 7| 3|
| 4| 7| 7| 9| 4| 7| 4| 4| 2| 7| 1| 3| 1| 2| 5| 2| 2| 2| 0| 2| 4| 1| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Lung | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Carcinoma, Metastatic, Parathyroid | |
Gland | X |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 2| 7| 7| 7| 6| 7| 6| 4| 7| 6| 7| 2| 7| 2| 7| 4| | |
DAY ON TEST | 5| 3| 3| 8| 8| 3| 3| 3| 2| 3| 4| 5| 3| 0| 3| 7| 3| 8| 3| 5| | |
| 3| 4| 4| 6| 2| 4| 4| 4| 5| 4| 9| 7| 4| 4| 4| 2| 4| 2| 4| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M + M + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + A + + + A + + | 41 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + A + + + A + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + A + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + A + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + A + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A + + + A + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + A + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + A + + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + A + + | 44 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 51 |
Carcinoma, Metastatic, Parathyroid | | |
Gland | | 1 |
Hepatocellular Carcinoma | X X X | 7 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X X X | 8 |
Hepatocellular Adenoma, Multiple | X | 1 |
Histiocytic Sarcoma | X | 6 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 16 |
Fat, Histiocytic Sarcoma | X | 2 |
Fat, Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + A + + | 47 |
Acinus, Lymphoma Malignant | | |
Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + A + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + A + + + + M + + + | 57 |
Squamous Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + | 58 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 2| 7| 7| 7| 6| 7| 6| 4| 7| 6| 7| 2| 7| 2| 7| 4| | |
DAY ON TEST | 5| 3| 3| 8| 8| 3| 3| 3| 2| 3| 4| 5| 3| 0| 3| 7| 3| 8| 3| 5| | |
| 3| 4| 4| 6| 2| 4| 4| 4| 5| 4| 9| 7| 4| 4| 4| 2| 4| 2| 4| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + | 50 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Pericardium, Leiomyosarcoma, | | |
Metastatic, Uterus | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + A + + + + + + | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + A + + + + + + | 48 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + A + + + A + + | 47 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + A + + | 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + + M + M + + + M + + + | 33 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + I + + + M + + + + | 48 |
Pars Distalis, Adenoma | | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + | 49 |
Carcinoma, Metastatic, Parathyroid | | |
Gland | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + A + + + + A + + + | 58 |
Adenoma | X | 1 |
Granulosa Cell Tumor Benign | | 1 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + | 60 |
Histiocytic Sarcoma | X | 2 |
Leiomyosarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 2| 7| 7| 7| 6| 7| 6| 4| 7| 6| 7| 2| 7| 2| 7| 4| | |
DAY ON TEST | 5| 3| 3| 8| 8| 3| 3| 3| 2| 3| 4| 5| 3| 0| 3| 7| 3| 8| 3| 5| | |
| 3| 4| 4| 6| 2| 4| 4| 4| 5| 4| 9| 7| 4| 4| 4| 2| 4| 2| 4| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + A + + + + + + | 48 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + | 50 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Iliac, Histiocytic Sarcoma | | 1 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Histiocytic Sarcoma | | 2 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + M + M + + | 42 |
Histiocytic Sarcoma | | 3 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + | 46 |
Histiocytic Sarcoma | | 3 |
Lymphoma Malignant Lymphocytic | | 2 |
Sarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + M + + M + M + + + + + M M | 33 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + | 48 |
Histiocytic Sarcoma | X | 5 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A + + + + + + | 48 |
Histiocytic Sarcoma | | 4 |
Lymphoma Malignant Lymphocytic | X X | 5 |
Lymphoma Malignant Mixed | X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + A + I + + + + | 45 |
Lymphoma Malignant Lymphocytic | X X | 6 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 2| 7| 7| 7| 6| 7| 6| 4| 7| 6| 7| 2| 7| 2| 7| 4| | |
DAY ON TEST | 5| 3| 3| 8| 8| 3| 3| 3| 2| 3| 4| 5| 3| 0| 3| 7| 3| 8| 3| 5| | |
| 3| 4| 4| 6| 2| 4| 4| 4| 5| 4| 9| 7| 4| 4| 4| 2| 4| 2| 4| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + A + + + + + + | 49 |
Adenoacanthoma | X | 2 |
Adenocarcinoma | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 50 |
Subcutaneous Tissue, Hemangioma | X | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 2 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Adenocarcinoma, Metastatic, Lung | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + | 50 |
Histiocytic Sarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + | 60 |
Adenocarcinoma | | 2 |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | | 1 |
Alveolar/Bronchiolar Adenoma | X X | 9 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 3 |
Alveolar/Bronchiolar Carcinoma | X X X X X | 10 |
Carcinoma, Metastatic, Parathyroid | | |
Gland | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 5 |
Histiocytic Sarcoma | X | 5 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 2| 7| 7| 7| 6| 7| 6| 4| 7| 6| 7| 2| 7| 2| 7| 4| | |
DAY ON TEST | 5| 3| 3| 8| 8| 3| 3| 3| 2| 3| 4| 5| 3| 0| 3| 7| 3| 8| 3| 5| | |
| 3| 4| 4| 6| 2| 4| 4| 4| 5| 4| 9| 7| 4| 4| 4| 2| 4| 2| 4| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | X | 1 |
Fat, Mediastinum, Hemangioma | X | 1 |
Mediastinum, Adenocarcinoma, | | |
Metastatic, Lung | | 2 |
Mediastinum, Hemangiosarcoma, | | |
Metastatic, Skin | | 1 |
Mediastinum, Hepatocellular | | |
Carcinoma, Metastatic, Liver | | 1 |
Mediastinum, Leiomyosarcoma, | | |
Metastatic, Uterus | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + M + + | 49 |
Adenocarcinoma | | 1 |
Adenoma | X | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + + + + | 48 |
Adenocarcinoma, Metastatic, Lung | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Carcinoma, Metastatic, Parathyroid | | |
Gland | | 1 |
Histiocytic Sarcoma | X | 5 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + | 48 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + | 60 |
Histiocytic Sarcoma | X | 7 |
Lymphoma Malignant Lymphocytic | X X | 6 |
Lymphoma Malignant Mixed | X X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 2| 4| 4| 5| 5| 2| 2| 4| 7| 6| 4| 4| 2| 4| 5| 4| 6| 6| 2| 5| 6| 6| 5| 7|
DAY ON TEST | 3| 8| 5| 5| 7| 4| 8| 8| 5| 3| 5| 5| 5| 8| 8| 3| 5| 4| 6| 8| 8| 5| 6| 3| 3|
| 3| 2| 7| 7| 0| 4| 2| 2| 7| 3| 3| 7| 7| 2| 5| 2| 7| 9| 4| 2| 6| 0| 5| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + M + + + + M + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + A +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + A +|
Carcinoma, Multiple | X |
Leiomyosarcoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + A + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | X |
Leiomyosarcoma, Metastatic, | |
Intestine Small | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | + +|
Histiocytic Sarcoma | |
Fat, Leiomyosarcoma, Metastatic, | |
Intestine Small | |
Fat, Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + A +|
Acinus, Carcinoma, Metastatic, Ovary | |
Acinus, Hemangioma | |
Acinus, Histiocytic Sarcoma | |
Acinus, Leiomyosarcoma, Metastatic, | |
Intestine Small | |
Acinus, Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + A +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + A + + + + + A +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + A +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 2| 4| 4| 5| 5| 2| 2| 4| 7| 6| 4| 4| 2| 4| 5| 4| 6| 6| 2| 5| 6| 6| 5| 7|
DAY ON TEST | 3| 8| 5| 5| 7| 4| 8| 8| 5| 3| 5| 5| 5| 8| 8| 3| 5| 4| 6| 8| 8| 5| 6| 3| 3|
| 3| 2| 7| 7| 0| 4| 2| 2| 7| 3| 3| 7| 7| 2| 5| 2| 7| 9| 4| 2| 6| 0| 5| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + A +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + A +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + A +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + A +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + A + + + + A +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + A +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M + M A M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + I + + + + M +|
Lymphoma Malignant Lymphocytic | |
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + A +|
Follicular Cell, Adenoma | X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X|
Carcinoma | |
Granulosa Cell Tumor Malignant | |
Granulosa Cell Tumor Benign | X X |
Hemangioma | |
Histiocytic Sarcoma | |
Leiomyosarcoma, Metastatic, | |
Intestine Small | |
Luteoma | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 2| 4| 4| 5| 5| 2| 2| 4| 7| 6| 4| 4| 2| 4| 5| 4| 6| 6| 2| 5| 6| 6| 5| 7|
DAY ON TEST | 3| 8| 5| 5| 7| 4| 8| 8| 5| 3| 5| 5| 5| 8| 8| 3| 5| 4| 6| 8| 8| 5| 6| 3| 3|
| 3| 2| 7| 7| 0| 4| 2| 2| 7| 3| 3| 7| 7| 2| 5| 2| 7| 9| 4| 2| 6| 0| 5| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Lymphoma Malignant | X |
Mixed Tumor Benign | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + A +|
Adenocarcinoma | |
Histiocytic Sarcoma | |
Leiomyoma | X |
Polyp Stromal | X X |
Sarcoma Stromal | |
Cervix, Hemangiosarcoma | |
__________________________________________________________________________|
Vagina | |
Hemangiosarcoma | |
Leiomyosarcoma | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A +|
Hemangiosarcoma, Metastatic, Skin | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M M + M + M + + M + + + M M + +|
Carcinoma, Metastatic, Ovary | |
Hemangiosarcoma, Metastatic, Heart | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + M + A +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + M + + + + + + M M M + + A M|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Carcinoma, Metastatic, Ovary | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + M + + +|
Carcinoma, Metastatic, Ovary | |
Histiocytic Sarcoma | X |
Leiomyosarcoma, Metastatic, | |
Intestine Small | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 2| 4| 4| 5| 5| 2| 2| 4| 7| 6| 4| 4| 2| 4| 5| 4| 6| 6| 2| 5| 6| 6| 5| 7|
DAY ON TEST | 3| 8| 5| 5| 7| 4| 8| 8| 5| 3| 5| 5| 5| 8| 8| 3| 5| 4| 6| 8| 8| 5| 6| 3| 3|
| 3| 2| 7| 7| 0| 4| 2| 2| 7| 3| 3| 7| 7| 2| 5| 2| 7| 9| 4| 2| 6| 0| 5| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + A +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + M A +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma | |
Adenocarcinoma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangioma | |
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Hemangiosarcoma,| |
Multiple | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Skeletal Muscle | |
Diaphragm, Leiomyosarcoma, | |
Metastatic, Intestine Small | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + A +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Alveolar/Bronchiolar Adenoma | X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 2| 4| 4| 5| 5| 2| 2| 4| 7| 6| 4| 4| 2| 4| 5| 4| 6| 6| 2| 5| 6| 6| 5| 7|
DAY ON TEST | 3| 8| 5| 5| 7| 4| 8| 8| 5| 3| 5| 5| 5| 8| 8| 3| 5| 4| 6| 8| 8| 5| 6| 3| 3|
| 3| 2| 7| 7| 0| 4| 2| 2| 7| 3| 3| 7| 7| 2| 5| 2| 7| 9| 4| 2| 6| 0| 5| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Carcinoma, Metastatic, Ovary | |
Granulosa Cell Tumor Malignant, | |
Metastatic, Ovary | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skin | |
Mediastinum, Adenocarcinoma, | |
Metastatic, Lung | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Mediastinum, Hemangiosarcoma, | |
Metastatic, Heart | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X X X |
Bilateral, Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + A +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 6| 6| 7| 2| 7| 5| 4| 4| 7| 4| 4| 2| 4| 2| 3| 6| 4| 6| 6|
DAY ON TEST | 2| 7| 4| 9| 1| 3| 8| 2| 3| 8| 3| 4| 1| 5| 3| 8| 5| 8| 0| 8| 9| 0| 4| 5| 2|
| 2| 0| 5| 8| 0| 9| 0| 5| 3| 2| 3| 6| 8| 7| 3| 5| 7| 2| 7| 2| 2| 8| 3| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M A + + + + + I + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + +|
Carcinoma, Multiple | |
Leiomyosarcoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma | X X X X X X|
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | |
Leiomyosarcoma, Metastatic, | |
Intestine Small | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + + + + + |
Histiocytic Sarcoma | X |
Fat, Leiomyosarcoma, Metastatic, | |
Intestine Small | X |
Fat, Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Acinus, Carcinoma, Metastatic, Ovary | |
Acinus, Hemangioma | |
Acinus, Histiocytic Sarcoma | X |
Acinus, Leiomyosarcoma, Metastatic, | |
Intestine Small | X |
Acinus, Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 6| 6| 7| 2| 7| 5| 4| 4| 7| 4| 4| 2| 4| 2| 3| 6| 4| 6| 6|
DAY ON TEST | 2| 7| 4| 9| 1| 3| 8| 2| 3| 8| 3| 4| 1| 5| 3| 8| 5| 8| 0| 8| 9| 0| 4| 5| 2|
| 2| 0| 5| 8| 0| 9| 0| 5| 3| 2| 3| 6| 8| 7| 3| 5| 7| 2| 7| 2| 2| 8| 3| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | I + + I + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + I + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + + + + + + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
Granulosa Cell Tumor Malignant | X X X |
Granulosa Cell Tumor Benign | X X X |
Hemangioma | X |
Histiocytic Sarcoma | |
Leiomyosarcoma, Metastatic, | |
Intestine Small | X |
Luteoma | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 6| 6| 7| 2| 7| 5| 4| 4| 7| 4| 4| 2| 4| 2| 3| 6| 4| 6| 6|
DAY ON TEST | 2| 7| 4| 9| 1| 3| 8| 2| 3| 8| 3| 4| 1| 5| 3| 8| 5| 8| 0| 8| 9| 0| 4| 5| 2|
| 2| 0| 5| 8| 0| 9| 0| 5| 3| 2| 3| 6| 8| 7| 3| 5| 7| 2| 7| 2| 2| 8| 3| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Lymphoma Malignant | |
Mixed Tumor Benign | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Histiocytic Sarcoma | X |
Leiomyoma | |
Polyp Stromal | |
Sarcoma Stromal | X |
Cervix, Hemangiosarcoma | |
__________________________________________________________________________|
Vagina | + |
Hemangiosarcoma | |
Leiomyosarcoma | X |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Skin | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M M + + + M + + + M + M + M + + + + + M|
Carcinoma, Metastatic, Ovary | |
Hemangiosarcoma, Metastatic, Heart | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + M + + + + + I|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + M M + + + + M + + M + + M + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Carcinoma, Metastatic, Ovary | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Ovary | |
Histiocytic Sarcoma | |
Leiomyosarcoma, Metastatic, | |
Intestine Small | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 6| 6| 7| 2| 7| 5| 4| 4| 7| 4| 4| 2| 4| 2| 3| 6| 4| 6| 6|
DAY ON TEST | 2| 7| 4| 9| 1| 3| 8| 2| 3| 8| 3| 4| 1| 5| 3| 8| 5| 8| 0| 8| 9| 0| 4| 5| 2|
| 2| 0| 5| 8| 0| 9| 0| 5| 3| 2| 3| 6| 8| 7| 3| 5| 7| 2| 7| 2| 2| 8| 3| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + M M|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma | X X X |
Adenocarcinoma | X X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangioma | |
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Hemangiosarcoma,| |
Multiple | |
Subcutaneous Tissue, Sarcoma | X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Leiomyosarcoma, | |
Metastatic, Intestine Small | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + I + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 6| 6| 7| 2| 7| 5| 4| 4| 7| 4| 4| 2| 4| 2| 3| 6| 4| 6| 6|
DAY ON TEST | 2| 7| 4| 9| 1| 3| 8| 2| 3| 8| 3| 4| 1| 5| 3| 8| 5| 8| 0| 8| 9| 0| 4| 5| 2|
| 2| 0| 5| 8| 0| 9| 0| 5| 3| 2| 3| 6| 8| 7| 3| 5| 7| 2| 7| 2| 2| 8| 3| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X |
Carcinoma, Metastatic, Ovary | |
Granulosa Cell Tumor Malignant, | |
Metastatic, Ovary | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Skin | X |
Mediastinum, Adenocarcinoma, | |
Metastatic, Lung | X|
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinum, Hemangiosarcoma, | |
Metastatic, Heart | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X |
Bilateral, Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Urinary Bladder | + + + + + I + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 2| 5| 4| 7| 2| 5| 6| 3| 7| 6| 4| 4| 7| 7| 7| | |
DAY ON TEST | 2| 6| 3| 9| 7| 8| 9| 4| 3| 8| 2| 5| 8| 0| 9| 5| 5| 3| 3| 3| | |
| 3| 9| 3| 4| 9| 2| 7| 3| 3| 2| 4| 3| 7| 7| 8| 7| 7| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
62.5 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + M + + + + + | 45 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A + + M + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + A + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + | 47 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + A + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + | 46 |
Carcinoma, Multiple | | 1 |
Leiomyosarcoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 61 |
Hemangiosarcoma | X | 1 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma | X X X | 9 |
Hepatocellular Adenoma | X X X X X | 10 |
Hepatocellular Adenoma, Multiple | X | 5 |
Histiocytic Sarcoma | X X | 3 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small | | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 9 |
Histiocytic Sarcoma | | 1 |
Fat, Leiomyosarcoma, Metastatic, | | |
Intestine Small | | 1 |
Fat, Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + | 48 |
Acinus, Carcinoma, Metastatic, Ovary | X | 1 |
Acinus, Hemangioma | X | 1 |
Acinus, Histiocytic Sarcoma | X | 2 |
Acinus, Leiomyosarcoma, Metastatic, | | |
Intestine Small | | 1 |
Acinus, Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 2| 5| 4| 7| 2| 5| 6| 3| 7| 6| 4| 4| 7| 7| 7| | |
DAY ON TEST | 2| 6| 3| 9| 7| 8| 9| 4| 3| 8| 2| 5| 8| 0| 9| 5| 5| 3| 3| 3| | |
| 3| 9| 3| 4| 9| 2| 7| 3| 3| 2| 4| 3| 7| 7| 8| 7| 7| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
62.5 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 68 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Squamous Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 68 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + | 59 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + I + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + | 47 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M M + + + | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + + + + | 47 |
Lymphoma Malignant Lymphocytic | | 1 |
Pars Distalis, Adenoma | X X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + | 49 |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 2| 5| 4| 7| 2| 5| 6| 3| 7| 6| 4| 4| 7| 7| 7| | |
DAY ON TEST | 2| 6| 3| 9| 7| 8| 9| 4| 3| 8| 2| 5| 8| 0| 9| 5| 5| 3| 3| 3| | |
| 3| 9| 3| 4| 9| 2| 7| 3| 3| 2| 4| 3| 7| 7| 8| 7| 7| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
62.5 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Adenoma | | 3 |
Carcinoma | X | 1 |
Granulosa Cell Tumor Malignant | | 3 |
Granulosa Cell Tumor Benign | X X | 7 |
Hemangioma | X | 2 |
Histiocytic Sarcoma | X X | 2 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small | | 1 |
Luteoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant | | 1 |
Mixed Tumor Benign | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 69 |
Adenocarcinoma | X X | 2 |
Histiocytic Sarcoma | | 1 |
Leiomyoma | | 1 |
Polyp Stromal | X | 3 |
Sarcoma Stromal | | 1 |
Cervix, Hemangiosarcoma | X | 1 |
__________________________________________________________________________|____________|
Vagina | + + | 3 |
Hemangiosarcoma | X | 1 |
Leiomyosarcoma | | 1 |
Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + | 59 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + | 60 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + M + M M + + + | 41 |
Carcinoma, Metastatic, Ovary | X | 1 |
Hemangiosarcoma, Metastatic, Heart | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant | | 1 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 2| 5| 4| 7| 2| 5| 6| 3| 7| 6| 4| 4| 7| 7| 7| | |
DAY ON TEST | 2| 6| 3| 9| 7| 8| 9| 4| 3| 8| 2| 5| 8| 0| 9| 5| 5| 3| 3| 3| | |
| 3| 9| 3| 4| 9| 2| 7| 3| 3| 2| 4| 3| 7| 7| 8| 7| 7| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
62.5 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + M + M + M M + + + | 49 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + M + M | 44 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Carcinoma, Metastatic, Ovary | X | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + | 58 |
Carcinoma, Metastatic, Ovary | X | 1 |
Histiocytic Sarcoma | X X | 3 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 58 |
Histiocytic Sarcoma | X X | 3 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + I I + + + + + + | 51 |
Lymphoma Malignant Lymphocytic | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + | 61 |
Adenoacanthoma | X X X | 6 |
Adenocarcinoma | X X | 6 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 53 |
Subcutaneous Tissue, Hemangioma | X | 1 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
Subcutaneous Tissue, Hemangiosarcoma,| | |
Multiple | | 1 |
Subcutaneous Tissue, Sarcoma | X X | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 2| 5| 4| 7| 2| 5| 6| 3| 7| 6| 4| 4| 7| 7| 7| | |
DAY ON TEST | 2| 6| 3| 9| 7| 8| 9| 4| 3| 8| 2| 5| 8| 0| 9| 5| 5| 3| 3| 3| | |
| 3| 9| 3| 4| 9| 2| 7| 3| 3| 2| 4| 3| 7| 7| 8| 7| 7| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
62.5 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Hemangiosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Diaphragm, Leiomyosarcoma, | | |
Metastatic, Intestine Small | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + | 50 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + I + + | 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenocarcinoma | | 2 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Alveolar/Bronchiolar Adenoma | X X X X | 16 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X | 4 |
Alveolar/Bronchiolar Carcinoma | X | 5 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 2 |
Carcinoma, Metastatic, Ovary | X | 1 |
Granulosa Cell Tumor Malignant, | | |
Metastatic, Ovary | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Histiocytic Sarcoma | X X | 3 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
Mediastinum, Adenocarcinoma, | | |
Metastatic, Lung | | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Mediastinum, Hemangiosarcoma, | | |
Metastatic, Heart | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 5| 2| 5| 4| 7| 2| 5| 6| 3| 7| 6| 4| 4| 7| 7| 7| | |
DAY ON TEST | 2| 6| 3| 9| 7| 8| 9| 4| 3| 8| 2| 5| 8| 0| 9| 5| 5| 3| 3| 3| | |
| 3| 9| 3| 4| 9| 2| 7| 3| 3| 2| 4| 3| 7| 7| 8| 7| 7| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
62.5 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + | 59 |
Adenoma | X X | 14 |
Bilateral, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + | 50 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + A + + + + | 46 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | X X | 4 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 5| 2| 5| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 6| 4| 5| 3| 5| 2| 4| 5| 5| 4| 2| 4|
DAY ON TEST | 6| 8| 0| 5| 5| 6| 9| 7| 5| 8| 5| 8| 5| 2| 6| 1| 7| 9| 8| 5| 9| 6| 1| 8| 5|
| 9| 2| 2| 7| 7| 0| 3| 1| 7| 5| 7| 2| 4| 9| 3| 3| 1| 7| 2| 7| 7| 9| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Granulocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma, Metastatic, Stomach | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leiomyosarcoma, Metastatic, Stomach | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Multiple | |
Hemangiosarcoma, Metastatic, Heart | X X X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X|
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | X |
Leiomyosarcoma, Metastatic, Stomach | X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Hemangiosarcoma, Metastatic, | |
Heart | X |
Fat, Histiocytic Sarcoma | |
Fat, Leiomyosarcoma, Metastatic, | |
Stomach | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Acinus, Leiomyosarcoma, Metastatic, | |
Stomach | X |
Acinus, Leukemia Granulocytic | |
Acinus, Lymphoma Malignant | |
Lymphocytic | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 5| 2| 5| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 6| 4| 5| 3| 5| 2| 4| 5| 5| 4| 2| 4|
DAY ON TEST | 6| 8| 0| 5| 5| 6| 9| 7| 5| 8| 5| 8| 5| 2| 6| 1| 7| 9| 8| 5| 9| 6| 1| 8| 5|
| 9| 2| 2| 7| 7| 0| 3| 1| 7| 5| 7| 2| 4| 9| 3| 3| 1| 7| 2| 7| 7| 9| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Leiomyosarcoma | X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X X |
Squamous Cell Papilloma, Multiple | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X X X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Histiocytic Sarcoma | X |
Leiomyosarcoma, Metastatic, Stomach | X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leiomyosarcoma, Metastatic, Stomach | X |
Leukemia Granulocytic | |
Pheochromocytoma Benign | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + I + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 5| 2| 5| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 6| 4| 5| 3| 5| 2| 4| 5| 5| 4| 2| 4|
DAY ON TEST | 6| 8| 0| 5| 5| 6| 9| 7| 5| 8| 5| 8| 5| 2| 6| 1| 7| 9| 8| 5| 9| 6| 1| 8| 5|
| 9| 2| 2| 7| 7| 0| 3| 1| 7| 5| 7| 2| 4| 9| 3| 3| 1| 7| 2| 7| 7| 9| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Granulosa Cell Tumor Malignant | X |
Granulosa Cell Tumor Benign | X X X |
Histiocytic Sarcoma | X |
Leiomyosarcoma, Metastatic, Stomach | X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
Mixed Tumor Benign | X X X X |
Bilateral, Granulosa Cell Tumor | |
Benign | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Hemangioma | X |
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | X X |
Axillary, Sarcoma, Metastatic, Skin | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X X |
Pancreatic, Histiocytic Sarcoma | |
Pancreatic, Leiomyosarcoma, | |
Metastatic, Stomach | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M M M M + + + + + + M + + + + M + + + + M|
Adenocarcinoma, Metastatic, Lung | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + + M M + + + + + + + I + + M + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + I + M + + + + + + M + + + + + + M + + M + + +|
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 5| 2| 5| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 6| 4| 5| 3| 5| 2| 4| 5| 5| 4| 2| 4|
DAY ON TEST | 6| 8| 0| 5| 5| 6| 9| 7| 5| 8| 5| 8| 5| 2| 6| 1| 7| 9| 8| 5| 9| 6| 1| 8| 5|
| 9| 2| 2| 7| 7| 0| 3| 1| 7| 5| 7| 2| 4| 9| 3| 3| 1| 7| 2| 7| 7| 9| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Metastatic, Lung | |
Histiocytic Sarcoma | X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leiomyosarcoma, Metastatic, Stomach | X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Thymus | I + + + + + + M + + + + + M + + + + + + + + + + M|
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma | X X |
Adenocarcinoma | X X X X X X |
Adenocarcinoma, Multiple | X|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma, Metastatic, Stomach | X |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Heart | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spinal Cord | + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 5| 2| 5| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 6| 4| 5| 3| 5| 2| 4| 5| 5| 4| 2| 4|
DAY ON TEST | 6| 8| 0| 5| 5| 6| 9| 7| 5| 8| 5| 8| 5| 2| 6| 1| 7| 9| 8| 5| 9| 6| 1| 8| 5|
| 9| 2| 2| 7| 7| 0| 3| 1| 7| 5| 7| 2| 4| 9| 3| 3| 1| 7| 2| 7| 7| 9| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Multiple | |
Adenocarcinoma, Metastatic, | |
Harderian Gland | |
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Alveolar/Bronchiolar Adenoma | X|
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X X X X|
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Granulosa Cell Tumor Malignant, | |
Metastatic, Ovary | X |
Hemangiosarcoma, Metastatic, Heart | X X X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Histiocytic Sarcoma | X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
Sarcoma, Metastatic, Skin | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinum, Hemangiosarcoma, | |
Metastatic, Heart | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenoma | X X X X X X X X X|
Bilateral, Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Heart | X |
Histiocytic Sarcoma | X |
Leiomyosarcoma, Metastatic, Stomach | X |
Leukemia Granulocytic | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 5| 2| 5| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 6| 4| 5| 3| 5| 2| 4| 5| 5| 4| 2| 4|
DAY ON TEST | 6| 8| 0| 5| 5| 6| 9| 7| 5| 8| 5| 8| 5| 2| 6| 1| 7| 9| 8| 5| 9| 6| 1| 8| 5|
| 9| 2| 2| 7| 7| 0| 3| 1| 7| 5| 7| 2| 4| 9| 3| 3| 1| 7| 2| 7| 7| 9| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 3| 5| 5| 4| 4| 6| 5| 4| 4| 4| 3| 4| 4| 4| 2| 4| 5| 5| 6| 0| 2| 7| 5| 2|
DAY ON TEST | 8| 5| 6| 6| 5| 5| 6| 0| 7| 8| 6| 7| 0| 1| 5| 0| 5| 2| 3| 2| 0| 8| 0| 0| 8|
| 2| 3| 9| 9| 7| 7| 3| 2| 2| 5| 4| 3| 8| 8| 7| 5| 7| 4| 2| 4| 9| 2| 4| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | A + + + + + + + + A + A + + + + + + + A A + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + A + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + A + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + M + I + + + + + + + A A + |
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + I + + + + + + + A + + |
Leiomyosarcoma, Metastatic, Stomach | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + |
Histiocytic Sarcoma | X |
Leiomyosarcoma, Metastatic, Stomach | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Hemangiosarcoma, Multiple | |
Hemangiosarcoma, Metastatic, Heart | X X X X X |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | X X X X |
Leiomyosarcoma, Metastatic, Stomach | |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Fat, Hemangiosarcoma, Metastatic, | |
Heart | |
Fat, Histiocytic Sarcoma | X X |
Fat, Leiomyosarcoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + |
Acinus, Leiomyosarcoma, Metastatic, | |
Stomach | |
Acinus, Leukemia Granulocytic | |
Acinus, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 3| 5| 5| 4| 4| 6| 5| 4| 4| 4| 3| 4| 4| 4| 2| 4| 5| 5| 6| 0| 2| 7| 5| 2|
DAY ON TEST | 8| 5| 6| 6| 5| 5| 6| 0| 7| 8| 6| 7| 0| 1| 5| 0| 5| 2| 3| 2| 0| 8| 0| 0| 8|
| 2| 3| 9| 9| 7| 7| 3| 2| 2| 5| 4| 3| 8| 8| 7| 5| 7| 4| 2| 4| 9| 2| 4| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Leiomyosarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X |
Squamous Cell Papilloma, Multiple | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X X X X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
Histiocytic Sarcoma | X X |
Leiomyosarcoma, Metastatic, Stomach | |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma | X |
Leiomyosarcoma, Metastatic, Stomach | |
Leukemia Granulocytic | |
Pheochromocytoma Benign | |
Sarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + |
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M M + + M + + + M M + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + |
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 3| 5| 5| 4| 4| 6| 5| 4| 4| 4| 3| 4| 4| 4| 2| 4| 5| 5| 6| 0| 2| 7| 5| 2|
DAY ON TEST | 8| 5| 6| 6| 5| 5| 6| 0| 7| 8| 6| 7| 0| 1| 5| 0| 5| 2| 3| 2| 0| 8| 0| 0| 8|
| 2| 3| 9| 9| 7| 7| 3| 2| 2| 5| 4| 3| 8| 8| 7| 5| 7| 4| 2| 4| 9| 2| 4| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Granulosa Cell Tumor Malignant | X |
Granulosa Cell Tumor Benign | X X X |
Histiocytic Sarcoma | X X |
Leiomyosarcoma, Metastatic, Stomach | |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X |
Mixed Tumor Benign | X X |
Bilateral, Granulosa Cell Tumor | |
Benign | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Hemangioma | |
Histiocytic Sarcoma | X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Axillary, Sarcoma, Metastatic, Skin | X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Pancreatic, Histiocytic Sarcoma | |
Pancreatic, Leiomyosarcoma, | |
Metastatic, Stomach | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M M + I + M + + + + + M M + + M + + M M|
Adenocarcinoma, Metastatic, Lung | X |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma | X X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + M + + + + + I + + + + + M + + + +|
Histiocytic Sarcoma | X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + M M + + + + + + + + + + + M M M + M M|
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 3| 5| 5| 4| 4| 6| 5| 4| 4| 4| 3| 4| 4| 4| 2| 4| 5| 5| 6| 0| 2| 7| 5| 2|
DAY ON TEST | 8| 5| 6| 6| 5| 5| 6| 0| 7| 8| 6| 7| 0| 1| 5| 0| 5| 2| 3| 2| 0| 8| 0| 0| 8|
| 2| 3| 9| 9| 7| 7| 3| 2| 2| 5| 4| 3| 8| 8| 7| 5| 7| 4| 2| 4| 9| 2| 4| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Metastatic, Lung | |
Histiocytic Sarcoma | X X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + M + + + + + M + + + +|
Histiocytic Sarcoma | X X X X |
Leiomyosarcoma, Metastatic, Stomach | |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Thymus | + + + + M + + + + M + + + + + + + M + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + A + + |
Adenoacanthoma | |
Adenocarcinoma | X X X X |
Adenocarcinoma, Multiple | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
Leiomyosarcoma, Metastatic, Stomach | |
Sebaceous Gland, Adenoma | X |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Sarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Sarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Hemangiosarcoma, Metastatic, Heart | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spinal Cord | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 3| 5| 5| 4| 4| 6| 5| 4| 4| 4| 3| 4| 4| 4| 2| 4| 5| 5| 6| 0| 2| 7| 5| 2|
DAY ON TEST | 8| 5| 6| 6| 5| 5| 6| 0| 7| 8| 6| 7| 0| 1| 5| 0| 5| 2| 3| 2| 0| 8| 0| 0| 8|
| 2| 3| 9| 9| 7| 7| 3| 2| 2| 5| 4| 3| 8| 8| 7| 5| 7| 4| 2| 4| 9| 2| 4| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Multiple | X |
Adenocarcinoma, Metastatic, | |
Harderian Gland | |
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Alveolar/Bronchiolar Adenoma | X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X X |
Alveolar/Bronchiolar Carcinoma | X X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X X X X X |
Granulosa Cell Tumor Malignant, | |
Metastatic, Ovary | |
Hemangiosarcoma, Metastatic, Heart | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X X X X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Skin | X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinum, Hemangiosarcoma, | |
Metastatic, Heart | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + M + + + + + + + |
Adenocarcinoma | |
Adenoma | X X X X X |
Bilateral, Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Hemangiosarcoma, Metastatic, Heart | |
Histiocytic Sarcoma | X X X |
Leiomyosarcoma, Metastatic, Stomach | |
Leukemia Granulocytic | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 3| 5| 5| 4| 4| 6| 5| 4| 4| 4| 3| 4| 4| 4| 2| 4| 5| 5| 6| 0| 2| 7| 5| 2|
DAY ON TEST | 8| 5| 6| 6| 5| 5| 6| 0| 7| 8| 6| 7| 0| 1| 5| 0| 5| 2| 3| 2| 0| 8| 0| 0| 8|
| 2| 3| 9| 9| 7| 7| 3| 2| 2| 5| 4| 3| 8| 8| 7| 5| 7| 4| 2| 4| 9| 2| 4| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
Renal Tubule, Adenoma | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X X |
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 6| 3| 4| 2| 3| 5| 5| 2| 5| 2| 4| 3| 3| 3| | |
DAY ON TEST | 8| 3| 4| 5| 7| 8| 9| 7| 7| 8| 8| 4| 0| 6| 6| 8| 8| 4| 1| 4| | |
| 4| 6| 6| 7| 0| 2| 5| 0| 8| 2| 6| 3| 9| 8| 9| 2| 9| 3| 7| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
200 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + M M + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + A + + + + A + A | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + M A + + + + A + + | 53 |
Histiocytic Sarcoma | | 1 |
Leukemia Granulocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + A + + + + + + + | 55 |
Leiomyosarcoma, Metastatic, Stomach | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A + + + + + + + A + + + + A + + | 54 |
Histiocytic Sarcoma | | 1 |
Leiomyosarcoma, Metastatic, Stomach | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 61 |
Hemangiosarcoma, Multiple | X | 1 |
Hemangiosarcoma, Metastatic, Heart | X X | 10 |
Hepatocellular Carcinoma | X | 8 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X | 10 |
Hepatocellular Adenoma, Multiple | X | 5 |
Histiocytic Sarcoma | X X | 7 |
Leiomyosarcoma, Metastatic, Stomach | | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 6 |
__________________________________________________________________________|____________|
Mesentery | + + | 15 |
Fat, Hemangiosarcoma, Metastatic, | | |
Heart | X | 2 |
Fat, Histiocytic Sarcoma | | 2 |
Fat, Leiomyosarcoma, Metastatic, | | |
Stomach | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 59 |
Acinus, Leiomyosarcoma, Metastatic, | | |
Stomach | | 1 |
Acinus, Leukemia Granulocytic | X | 1 |
Acinus, Lymphoma Malignant | | |
Lymphocytic | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 6| 3| 4| 2| 3| 5| 5| 2| 5| 2| 4| 3| 3| 3| | |
DAY ON TEST | 8| 3| 4| 5| 7| 8| 9| 7| 7| 8| 8| 4| 0| 6| 6| 8| 8| 4| 1| 4| | |
| 4| 6| 6| 7| 0| 2| 5| 0| 8| 2| 6| 3| 9| 8| 9| 2| 9| 3| 7| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
200 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 60 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Leiomyosarcoma | | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | X | 4 |
Squamous Cell Papilloma, Multiple | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 68 |
Lymphoma Malignant Lymphocytic | X X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangiosarcoma | X X X X X X X | 22 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + | 60 |
Adenoma | X | 3 |
Histiocytic Sarcoma | | 3 |
Leiomyosarcoma, Metastatic, Stomach | | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Sarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Leiomyosarcoma, Metastatic, Stomach | | 1 |
Leukemia Granulocytic | X | 1 |
Pheochromocytoma Benign | X | 2 |
Sarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + | 59 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + I + + M + + + + + M + + + + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 6| 3| 4| 2| 3| 5| 5| 2| 5| 2| 4| 3| 3| 3| | |
DAY ON TEST | 8| 3| 4| 5| 7| 8| 9| 7| 7| 8| 8| 4| 0| 6| 6| 8| 8| 4| 1| 4| | |
| 4| 6| 6| 7| 0| 2| 5| 0| 8| 2| 6| 3| 9| 8| 9| 2| 9| 3| 7| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
200 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 59 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenoma | X | 1 |
Granulosa Cell Tumor Malignant | X | 3 |
Granulosa Cell Tumor Benign | X X X | 9 |
Histiocytic Sarcoma | | 3 |
Leiomyosarcoma, Metastatic, Stomach | | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 4 |
Mixed Tumor Benign | | 6 |
Bilateral, Granulosa Cell Tumor | | |
Benign | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenocarcinoma | X | 1 |
Hemangioma | | 1 |
Histiocytic Sarcoma | | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | X X | 4 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 5 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 69 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Axillary, Sarcoma, Metastatic, Skin | | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 6| 3| 4| 2| 3| 5| 5| 2| 5| 2| 4| 3| 3| 3| | |
DAY ON TEST | 8| 3| 4| 5| 7| 8| 9| 7| 7| 8| 8| 4| 0| 6| 6| 8| 8| 4| 1| 4| | |
| 4| 6| 6| 7| 0| 2| 5| 0| 8| 2| 6| 3| 9| 8| 9| 2| 9| 3| 7| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
200 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Histiocytic Sarcoma | X | 1 |
Pancreatic, Leiomyosarcoma, | | |
Metastatic, Stomach | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M M + + M + + M M + + + M + + + + | 46 |
Adenocarcinoma, Metastatic, Lung | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Histiocytic Sarcoma | | 3 |
Lymphoma Malignant Lymphocytic | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + M + + M I M + + + M + + | 54 |
Histiocytic Sarcoma | X | 2 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M M + + M + + + + + M + M + M | 51 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X | 2 |
Histiocytic Sarcoma | | 3 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 66 |
Histiocytic Sarcoma | X | 6 |
Leiomyosarcoma, Metastatic, Stomach | | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 6 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | X | 4 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 6 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + M + + + + + I + + + | 59 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + | 58 |
Adenoacanthoma | X X | 4 |
Adenocarcinoma | X X | 12 |
Adenocarcinoma, Multiple | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 6| 3| 4| 2| 3| 5| 5| 2| 5| 2| 4| 3| 3| 3| | |
DAY ON TEST | 8| 3| 4| 5| 7| 8| 9| 7| 7| 8| 8| 4| 0| 6| 6| 8| 8| 4| 1| 4| | |
| 4| 6| 6| 7| 0| 2| 5| 0| 8| 2| 6| 3| 9| 8| 9| 2| 9| 3| 7| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
200 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 60 |
Leiomyosarcoma, Metastatic, Stomach | | 1 |
Sebaceous Gland, Adenoma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 2 |
Subcutaneous Tissue, Sarcoma | | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Diaphragm, Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 60 |
Hemangiosarcoma, Metastatic, Heart | X | 2 |
Histiocytic Sarcoma | X X | 4 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenocarcinoma, Multiple | | 1 |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | X | 1 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | X X | 3 |
Alveolar/Bronchiolar Adenoma | X X X X X | 13 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 5 |
Alveolar/Bronchiolar Carcinoma | X | 9 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X X X | 10 |
Granulosa Cell Tumor Malignant, | | |
Metastatic, Ovary | | 1 |
Hemangiosarcoma, Metastatic, Heart | X | 6 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 3 |
Histiocytic Sarcoma | X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 6| 3| 4| 2| 3| 5| 5| 2| 5| 2| 4| 3| 3| 3| | |
DAY ON TEST | 8| 3| 4| 5| 7| 8| 9| 7| 7| 8| 8| 4| 0| 6| 6| 8| 8| 4| 1| 4| | |
| 4| 6| 6| 7| 0| 2| 5| 0| 8| 2| 6| 3| 9| 8| 9| 2| 9| 3| 7| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
200 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 5 |
Sarcoma, Metastatic, Skin | | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X X | 2 |
Mediastinum, Hemangiosarcoma, | | |
Metastatic, Heart | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + | 60 |
Adenocarcinoma | X | 1 |
Adenoma | X X X X X X X | 21 |
Bilateral, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 60 |
Hemangiosarcoma, Metastatic, Heart | | 1 |
Histiocytic Sarcoma | X | 5 |
Leiomyosarcoma, Metastatic, Stomach | | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 5 |
Renal Tubule, Adenoma | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 59 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 |
Histiocytic Sarcoma | X X | 7 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X X | 9 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 4| 3| 2| 3| 2| 2|
DAY ON TEST | 5| 4| 0| 9| 7| 1| 8| 9| 2| 1| 1| 8| 3| 8| 2| 0| 8| 8| 1| 4| 7| 0| 8| 0| 8|
| 3| 0| 7| 4| 5| 7| 2| 8| 8| 7| 9| 2| 1| 0| 9| 7| 2| 7| 9| 3| 9| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + A A + + + + + A M + A + + + + + + + M + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + + + + + + + + A + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + A A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + + + + + + A + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A A + + + + + A + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Hemangiosarcoma, Multiple | |
Hemangiosarcoma, Metastatic, Heart | X X X X X X |
Hemangiosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X X X X X X X X|
Lymphoma Malignant | |
Sarcoma, Metastatic, Mammary Gland | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Mesentery | + + + |
Sarcoma, Metastatic, Mammary Gland | X |
Fat, Hemangiosarcoma, Metastatic, | |
Heart | X |
Fat, Hemangiosarcoma, Metastatic, | |
Spleen | |
Fat, Sarcoma, Metastatic, Stomach | X |
Fat, Squamous Cell Carcinoma, | |
Metastatic, Stomach | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Mammary Gland | X |
Acinus, Lymphoma Malignant | |
Lymphocytic | X X X X|
Acinus, Squamous Cell Carcinoma, | |
Metastatic, Stomach | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 4| 3| 2| 3| 2| 2|
DAY ON TEST | 5| 4| 0| 9| 7| 1| 8| 9| 2| 1| 1| 8| 3| 8| 2| 0| 8| 8| 1| 4| 7| 0| 8| 0| 8|
| 3| 0| 7| 4| 5| 7| 2| 8| 8| 7| 9| 2| 1| 0| 9| 7| 2| 7| 9| 3| 9| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
Sarcoma | X |
Sarcoma, Metastatic, Mammary Gland | X |
Squamous Cell Carcinoma | X X |
Squamous Cell Papilloma | X X |
Squamous Cell Papilloma, Multiple | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X |
Sarcoma, Metastatic, Mammary Gland | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X X X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X |
Sarcoma, Metastatic, Mammary Gland | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X |
Sarcoma, Metastatic, Stomach | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M + + M + + + + + + + M M + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + M M + + I + + + + + + + + + + + + M +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 4| 3| 2| 3| 2| 2|
DAY ON TEST | 5| 4| 0| 9| 7| 1| 8| 9| 2| 1| 1| 8| 3| 8| 2| 0| 8| 8| 1| 4| 7| 0| 8| 0| 8|
| 3| 0| 7| 4| 5| 7| 2| 8| 8| 7| 9| 2| 1| 0| 9| 7| 2| 7| 9| 3| 9| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Granulosa Cell Tumor Benign | X X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X X|
Mixed Tumor Benign | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X X |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + I + + +|
Histiocytic Sarcoma | |
Axillary, Lymphoma Malignant | |
Lymphocytic | X X |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + M + M + + + M + + + M M M M M M + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X X X X X|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + M + + I + + I + + I + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Lymphoma Malignant Lymphocytic | X X X X X X X|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + M + + + + M + + M + + +|
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 4| 3| 2| 3| 2| 2|
DAY ON TEST | 5| 4| 0| 9| 7| 1| 8| 9| 2| 1| 1| 8| 3| 8| 2| 0| 8| 8| 1| 4| 7| 0| 8| 0| 8|
| 3| 0| 7| 4| 5| 7| 2| 8| 8| 7| 9| 2| 1| 0| 9| 7| 2| 7| 9| 3| 9| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Metastatic, Lung | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X X X X X|
Lymphoma Malignant | |
Sarcoma, Metastatic, Mammary Gland | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + I + + + + + + + M M + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X X X X X X X|
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + I + + + + M + + + + + + + M + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X X X X|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Mixed Tumor Malignant | X |
Sarcoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Lymphoma Malignant Lymphocytic | X |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma,| |
Metastatic, Heart | X |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Sarcoma, | |
Multiple | |
Subcutaneous Tissue, Squamous Cell | |
Carcinoma, Metastatic, Stomach | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 4| 3| 2| 3| 2| 2|
DAY ON TEST | 5| 4| 0| 9| 7| 1| 8| 9| 2| 1| 1| 8| 3| 8| 2| 0| 8| 8| 1| 4| 7| 0| 8| 0| 8|
| 3| 0| 7| 4| 5| 7| 2| 8| 8| 7| 9| 2| 1| 0| 9| 7| 2| 7| 9| 3| 9| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Sarcoma, Metastatic, | |
Stomach | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Heart | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X|
__________________________________________________________________________|
Spinal Cord | + + +|
Lymphoma Malignant Lymphocytic | X X X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Alveolar/Bronchiolar Adenoma | X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Hemangiosarcoma, Metastatic, Heart | X X X X X |
Hemangiosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X X X X |
Mixed Tumor Malignant, Metastatic, | |
Mammary Gland | X |
Sarcoma, Metastatic, Skin | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Mediastinum, Hemangiosarcoma, | |
Metastatic, Heart | |
Mediastinum, Mixed Tumor Malignant, | |
Metastatic, Mammary Gland | X |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 4| 3| 2| 3| 2| 2|
DAY ON TEST | 5| 4| 0| 9| 7| 1| 8| 9| 2| 1| 1| 8| 3| 8| 2| 0| 8| 8| 1| 4| 7| 0| 8| 0| 8|
| 3| 0| 7| 4| 5| 7| 2| 8| 8| 7| 9| 2| 1| 0| 9| 7| 2| 7| 9| 3| 9| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Sarcoma, Metastatic, | |
Skin | |
Mediastinum, Squamous Cell Carcinoma,| |
Metastatic, Stomach | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Trachea | + + + A + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + M + + + + + + + + + I + + + + + + + + + M + M +|
Adenoma | X X |
__________________________________________________________________________|
Zymbal's Gland | |
Adenoma | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hemangiosarcoma, Metastatic, Heart | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X X X X X|
Lymphoma Malignant | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | |
Lymphoma Malignant Lymphocytic | X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 1| 3| 3| 2| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2|
DAY ON TEST | 5| 8| 3| 2| 8| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7|
| 9| 9| 5| 5| 2| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + I A + + I + + + A + A + + A + A A A + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + A + + + A + + + A + + + + + + + A + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + A + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + A + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small | + A + + + A + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + A + + + A + + + + + + + + M + + A A + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A + + + A + + + A + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + A M + + A + A + A + A + + A + + A + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Hemangiosarcoma, Multiple | X |
Hemangiosarcoma, Metastatic, Heart | X X X X X X |
Hemangiosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X X X X X|
Lymphoma Malignant | X |
Sarcoma, Metastatic, Mammary Gland | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Mesentery | |
Sarcoma, Metastatic, Mammary Gland | |
Fat, Hemangiosarcoma, Metastatic, | |
Heart | |
Fat, Hemangiosarcoma, Metastatic, | |
Spleen | |
Fat, Sarcoma, Metastatic, Stomach | |
Fat, Squamous Cell Carcinoma, | |
Metastatic, Stomach | |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Mammary Gland | |
Acinus, Lymphoma Malignant | |
Lymphocytic | X |
Acinus, Squamous Cell Carcinoma, | |
Metastatic, Stomach | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 1| 3| 3| 2| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2|
DAY ON TEST | 5| 8| 3| 2| 8| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7|
| 9| 9| 5| 5| 2| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Sarcoma | |
Sarcoma, Metastatic, Mammary Gland | |
Squamous Cell Carcinoma | X|
Squamous Cell Papilloma | X X X X X |
Squamous Cell Papilloma, Multiple | |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X |
Sarcoma, Metastatic, Mammary Gland | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X X X X X X|
Sarcoma, Metastatic, Mammary Gland | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X |
Sarcoma, Metastatic, Stomach | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + A + + + + + + + + + + + A + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + M + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + + + + I + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X X|
__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 1| 3| 3| 2| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2|
DAY ON TEST | 5| 8| 3| 2| 8| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7|
| 9| 9| 5| 5| 2| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + A + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Granulosa Cell Tumor Benign | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X X X X X|
Mixed Tumor Benign | |
__________________________________________________________________________|
Uterus | + A + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Axillary, Lymphoma Malignant | |
Lymphocytic | X X X |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X X |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + M + + + + + + + + + + M M + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X X X X X X X X|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + M + M M I M + + + + + + + + + + + M +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Lymphoma Malignant Lymphocytic | X X X X X X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + + + + M + + + M M + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 1| 3| 3| 2| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2|
DAY ON TEST | 5| 8| 3| 2| 8| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7|
| 9| 9| 5| 5| 2| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Metastatic, Lung | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X X X X X|
Lymphoma Malignant | X |
Sarcoma, Metastatic, Mammary Gland | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + M + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + M + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X X X X X X|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Mixed Tumor Malignant | X |
Sarcoma | |
__________________________________________________________________________|
Skin | + A + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Lymphoma Malignant Lymphocytic | |
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Hemangiosarcoma,| |
Metastatic, Heart | |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
Subcutaneous Tissue, Sarcoma | |
Subcutaneous Tissue, Sarcoma, | |
Multiple | |
Subcutaneous Tissue, Squamous Cell | |
Carcinoma, Metastatic, Stomach | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 1| 3| 3| 2| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2|
DAY ON TEST | 5| 8| 3| 2| 8| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7|
| 9| 9| 5| 5| 2| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Skeletal Muscle | |
Diaphragm, Sarcoma, Metastatic, | |
Stomach | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Heart | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X |
__________________________________________________________________________|
Spinal Cord | + + |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + A + + + A + + + + + I + + + + I + + + + + + + +|
__________________________________________________________________________|
Lung | + A + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X X |
Alveolar/Bronchiolar Adenoma | X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hemangiosarcoma, Metastatic, Heart | X X X X X |
Hemangiosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X X X X|
Mixed Tumor Malignant, Metastatic, | |
Mammary Gland | X |
Sarcoma, Metastatic, Skin | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinum, Hemangiosarcoma, | |
Metastatic, Heart | |
Mediastinum, Mixed Tumor Malignant, | |
Metastatic, Mammary Gland | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 1| 3| 3| 2| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2|
DAY ON TEST | 5| 8| 3| 2| 8| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7|
| 9| 9| 5| 5| 2| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Sarcoma, Metastatic, | |
Skin | |
Mediastinum, Squamous Cell Carcinoma,| |
Metastatic, Stomach | |
__________________________________________________________________________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + A + + + A + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Harderian Gland | I I + + + + + + + + + + + M + + M + + M + + + + +|
Adenoma | X |
__________________________________________________________________________|
Zymbal's Gland | + |
Adenoma | X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hemangiosarcoma, Metastatic, Heart | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X X X X|
Lymphoma Malignant | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + A + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
Lymphoma Malignant Lymphocytic | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 3| 3| 3| 4| 2| 2| 2| 0| 2| 2| 3| 2| 3| 2| 2| 2| 4| 3| 2| 4| 4| 2| 3| 3|
DAY ON TEST | 0| 8| 4| 3| 5| 8| 7| 2| 1| 8| 8| 9| 8| 0| 4| 8| 8| 2| 5| 5| 2| 1| 9| 2| 7|
| 1| 7| 1| 0| 7| 5| 2| 1| 1| 2| 2| 2| 0| 0| 6| 2| 2| 5| 6| 3| 5| 8| 6| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + A + + + + + A A + + A A + A|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + A A + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + + + + + + + + + + A A + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + M + + + + + A A + + A A + A|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + M + + + + + + + A + + + A A + A|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + A + + + + + + + A + A A + A|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Hemangiosarcoma, Multiple | |
Hemangiosarcoma, Metastatic, Heart | X X X|
Hemangiosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mammary Gland | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Mesentery | + + |
Sarcoma, Metastatic, Mammary Gland | |
Fat, Hemangiosarcoma, Metastatic, | |
Heart | |
Fat, Hemangiosarcoma, Metastatic, | |
Spleen | X |
Fat, Sarcoma, Metastatic, Stomach | |
Fat, Squamous Cell Carcinoma, | |
Metastatic, Stomach | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +|
Sarcoma, Metastatic, Mammary Gland | |
Acinus, Lymphoma Malignant | |
Lymphocytic | |
Acinus, Squamous Cell Carcinoma, | |
Metastatic, Stomach | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 3| 3| 3| 4| 2| 2| 2| 0| 2| 2| 3| 2| 3| 2| 2| 2| 4| 3| 2| 4| 4| 2| 3| 3|
DAY ON TEST | 0| 8| 4| 3| 5| 8| 7| 2| 1| 8| 8| 9| 8| 0| 4| 8| 8| 2| 5| 5| 2| 1| 9| 2| 7|
| 1| 7| 1| 0| 7| 5| 2| 1| 1| 2| 2| 2| 0| 0| 6| 2| 2| 5| 6| 3| 5| 8| 6| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Sarcoma | |
Sarcoma, Metastatic, Mammary Gland | |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X X X X X|
Squamous Cell Papilloma, Multiple | X |
__________________________________________________________________________|
Stomach, Glandular | + + + M + + + + + + + + + + + + + + + + + + A + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Mammary Gland | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X X X |
Sarcoma, Metastatic, Mammary Gland | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + A + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Sarcoma, Metastatic, Stomach | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + + + + + + A + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + M + + M + + M + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + I + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 3| 3| 3| 4| 2| 2| 2| 0| 2| 2| 3| 2| 3| 2| 2| 2| 4| 3| 2| 4| 4| 2| 3| 3|
DAY ON TEST | 0| 8| 4| 3| 5| 8| 7| 2| 1| 8| 8| 9| 8| 0| 4| 8| 8| 2| 5| 5| 2| 1| 9| 2| 7|
| 1| 7| 1| 0| 7| 5| 2| 1| 1| 2| 2| 2| 0| 0| 6| 2| 2| 5| 6| 3| 5| 8| 6| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Granulosa Cell Tumor Benign | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X |
Mixed Tumor Benign | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + A + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | M |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + M + + + + + + M + + M M M + + + + + + M|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + M + M + M + + + + M M + + M + A + M|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + M + + + M + + M + M + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 3| 3| 3| 4| 2| 2| 2| 0| 2| 2| 3| 2| 3| 2| 2| 2| 4| 3| 2| 4| 4| 2| 3| 3|
DAY ON TEST | 0| 8| 4| 3| 5| 8| 7| 2| 1| 8| 8| 9| 8| 0| 4| 8| 8| 2| 5| 5| 2| 1| 9| 2| 7|
| 1| 7| 1| 0| 7| 5| 2| 1| 1| 2| 2| 2| 0| 0| 6| 2| 2| 5| 6| 3| 5| 8| 6| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Metastatic, Lung | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X X X X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mammary Gland | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + I + + A + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + A + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X |
Mixed Tumor Malignant | X |
Sarcoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Lymphoma Malignant Lymphocytic | |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma,| |
Metastatic, Heart | X|
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Sarcoma, | |
Multiple | |
Subcutaneous Tissue, Squamous Cell | |
Carcinoma, Metastatic, Stomach | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 3| 3| 3| 4| 2| 2| 2| 0| 2| 2| 3| 2| 3| 2| 2| 2| 4| 3| 2| 4| 4| 2| 3| 3|
DAY ON TEST | 0| 8| 4| 3| 5| 8| 7| 2| 1| 8| 8| 9| 8| 0| 4| 8| 8| 2| 5| 5| 2| 1| 9| 2| 7|
| 1| 7| 1| 0| 7| 5| 2| 1| 1| 2| 2| 2| 0| 0| 6| 2| 2| 5| 6| 3| 5| 8| 6| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Sarcoma, Metastatic, | |
Stomach | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Heart | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Spinal Cord | + + + |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + I + + + + + + + + + + + + + + + + + + + A + I|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + A + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Hemangiosarcoma, Metastatic, Heart | X X X X|
Hemangiosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X X |
Mixed Tumor Malignant, Metastatic, | |
Mammary Gland | X |
Sarcoma, Metastatic, Skin | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X X |
Mediastinum, Hemangiosarcoma, | |
Metastatic, Heart | X |
Mediastinum, Mixed Tumor Malignant, | |
Metastatic, Mammary Gland | |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 4| 3| 3| 3| 4| 2| 2| 2| 0| 2| 2| 3| 2| 3| 2| 2| 2| 4| 3| 2| 4| 4| 2| 3| 3|
DAY ON TEST | 0| 8| 4| 3| 5| 8| 7| 2| 1| 8| 8| 9| 8| 0| 4| 8| 8| 2| 5| 5| 2| 1| 9| 2| 7|
| 1| 7| 1| 0| 7| 5| 2| 1| 1| 2| 2| 2| 0| 0| 6| 2| 2| 5| 6| 3| 5| 8| 6| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Sarcoma, Metastatic, | |
Skin | |
Mediastinum, Squamous Cell Carcinoma,| |
Metastatic, Stomach | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Trachea | + + A + + + + + + + + + + + + + + + + + + + A + A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + M + + M + + + M + M + + + + + + + +|
Adenoma | X X X X |
__________________________________________________________________________|
Zymbal's Gland | + |
Adenoma | |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Hemangiosarcoma, Metastatic, Heart | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Lymphocytic | X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
Lymphoma Malignant Lymphocytic | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3| | |
DAY ON TEST | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6| | |
| 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + M + + + | 89 |
__________________________________________________________________________|____________|
Gallbladder | A + + + + + + + + + + + A + + | 64 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 87 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + | 78 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 83 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + | 83 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + A + + | 72 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + A + + | 75 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 90 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Hemangiosarcoma, Multiple | | 1 |
Hemangiosarcoma, Metastatic, Heart | X X X X X | 20 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | X | 2 |
Histiocytic Sarcoma | | 4 |
Lymphoma Malignant Lymphocytic | X X X X | 23 |
Lymphoma Malignant | | 1 |
Sarcoma, Metastatic, Mammary Gland | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | X X | 2 |
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Sarcoma, Metastatic, Mammary Gland | | 1 |
Fat, Hemangiosarcoma, Metastatic, | | |
Heart | | 1 |
Fat, Hemangiosarcoma, Metastatic, | | |
Spleen | | 1 |
Fat, Sarcoma, Metastatic, Stomach | | 1 |
Fat, Squamous Cell Carcinoma, | | |
Metastatic, Stomach | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 88 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 96
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3| | |
DAY ON TEST | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6| | |
| 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Mammary Gland | | 1 |
Acinus, Lymphoma Malignant | | |
Lymphocytic | X X | 7 |
Acinus, Squamous Cell Carcinoma, | | |
Metastatic, Stomach | X X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 89 |
Lymphoma Malignant Lymphocytic | X | 5 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 89 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 89 |
Lymphoma Malignant Lymphocytic | X X | 7 |
Sarcoma | | 1 |
Sarcoma, Metastatic, Mammary Gland | | 1 |
Squamous Cell Carcinoma | X X X | 7 |
Squamous Cell Papilloma | X X X | 15 |
Squamous Cell Papilloma, Multiple | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 86 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X X | 7 |
Sarcoma, Metastatic, Mammary Gland | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 90 |
Hemangiosarcoma | X X X X X | 25 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X X X | 19 |
Sarcoma, Metastatic, Mammary Gland | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 88 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 88 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Lymphocytic | X | 9 |
Sarcoma, Metastatic, Stomach | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 86 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 97
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3| | |
DAY ON TEST | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6| | |
| 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 88 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + + + + + + + + + + + | 77 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + I + + + + + + | 80 |
Lymphoma Malignant Lymphocytic | X | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 88 |
Lymphoma Malignant Lymphocytic | X | 2 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 89 |
Adenoma | | 1 |
Granulosa Cell Tumor Benign | X X | 7 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X X X | 19 |
Mixed Tumor Benign | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 88 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 9 |
Polyp Stromal | X X | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 89 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Lymphocytic | X X X X X X X | 31 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 89 |
Histiocytic Sarcoma | | 1 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | X | 6 |
Deep Cervical, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Inguinal, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 98
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3| | |
DAY ON TEST | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6| | |
| 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphocytic | | 4 |
Renal, Lymphoma Malignant Lymphocytic| | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M M + M M M + + + M + + + | 62 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X X X X X | 29 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M I + + + + I + M M + + + + | 64 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | X | 1 |
Lymphoma Malignant Lymphocytic | X X X X X | 23 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + M M + + + + + + + + | 74 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X X X X X X X | 29 |
Lymphoma Malignant | | 1 |
Sarcoma, Metastatic, Mammary Gland | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M M + + + + + + + | 81 |
Histiocytic Sarcoma | | 4 |
Lymphoma Malignant Lymphocytic | X X X X X X | 24 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 88 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 4 |
Lymphoma Malignant Lymphocytic | X X X X X X X | 27 |
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + + + + + + + | 81 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 3 |
Lymphoma Malignant Lymphocytic | X X X X X X X | 31 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 99
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3| | |
DAY ON TEST | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6| | |
| 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + M + + + | 87 |
Adenocarcinoma | X X X | 13 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 5 |
Mixed Tumor Malignant | X | 4 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 89 |
Keratoacanthoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 2 |
Subcutaneous Tissue, Hemangiosarcoma,| | |
Metastatic, Heart | | 2 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | X | 1 |
Subcutaneous Tissue, Sarcoma | | 2 |
Subcutaneous Tissue, Sarcoma, | | |
Multiple | X | 1 |
Subcutaneous Tissue, Squamous Cell | | |
Carcinoma, Metastatic, Stomach | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 90 |
Vertebra, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Diaphragm, Sarcoma, Metastatic, | | |
Stomach | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 90 |
Hemangiosarcoma, Metastatic, Heart | X | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 10 |
__________________________________________________________________________|____________|
Spinal Cord | + | 9 |
Lymphoma Malignant Lymphocytic | X | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | A + + + + + + + + + + + + + + | 82 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 88 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 100
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3| | |
DAY ON TEST | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6| | |
| 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | X | 5 |
Alveolar/Bronchiolar Adenoma | | 15 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 4 |
Alveolar/Bronchiolar Carcinoma | | 5 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 3 |
Hemangiosarcoma, Metastatic, Heart | X | 15 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 4 |
Lymphoma Malignant Lymphocytic | X X X X X | 22 |
Mixed Tumor Malignant, Metastatic, | | |
Mammary Gland | | 3 |
Sarcoma, Metastatic, Skin | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | X | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 3 |
Mediastinum, Hemangiosarcoma, | | |
Metastatic, Heart | | 1 |
Mediastinum, Mixed Tumor Malignant, | | |
Metastatic, Mammary Gland | | 1 |
Mediastinum, Sarcoma, Metastatic, | | |
Skin | X | 1 |
Mediastinum, Squamous Cell Carcinoma,| | |
Metastatic, Stomach | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 89 |
Lymphoma Malignant Lymphocytic | X | 5 |
__________________________________________________________________________|____________|
Trachea | A + + + + + + + + + + + + + + | 83 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + + M M + + M + + + + + M + + | 73 |
Adenoma | X X X | 10 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 101
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3| | |
DAY ON TEST | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6| | |
| 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
625 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 90 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Hemangiosarcoma, Metastatic, Heart | X | 1 |
Histiocytic Sarcoma | | 4 |
Lymphoma Malignant Lymphocytic | X X X X X | 21 |
Lymphoma Malignant | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + A + + | 85 |
Lymphoma Malignant Lymphocytic | X X | 9 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 90 |
Histiocytic Sarcoma | | 4 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Lymphocytic | X X X X X X X | 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 102
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 2| 4| 7| 2| 7| 7| 7| 6| 2| 6| 5| 6| 7| 7| 7| 2| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 8| 5| 3| 8| 3| 3| 3| 2| 8| 6| 1| 5| 3| 3| 3| 8| 3| 3| 5| 3| 7| 3| 3| 3|
| 6| 1| 6| 6| 1| 6| 6| 6| 7| 1| 6| 1| 2| 6| 6| 6| 1| 6| 6| 6| 6| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | |
Hepatocholangiocarcinoma | |
Lymphoma Malignant Lymphocytic | X X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Lymphoma Malignant | |
Lymphocytic | X |
Acinus, Lymphoma Malignant Mixed | X |
Acinus, Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor NOS, Metastatic, | |
Bone Marrow | |
Sarcoma, Metastatic, Skin | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 2| 4| 7| 2| 7| 7| 7| 6| 2| 6| 5| 6| 7| 7| 7| 2| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 8| 5| 3| 8| 3| 3| 3| 2| 8| 6| 1| 5| 3| 3| 3| 8| 3| 3| 5| 3| 7| 3| 3| 3|
| 6| 1| 6| 6| 1| 6| 6| 6| 7| 1| 6| 1| 2| 6| 6| 6| 1| 6| 6| 6| 6| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
Bilateral, Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + M M + + I + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + |
__________________________________________________________________________|
Prostate | + + + + + + + + M + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor NOS | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Mast Cell Tumor NOS, Metastatic, | |
Bone Marrow | |
Iliac, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + + + + + + + M M|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + M + + + M M M M + + + + M + + +|
Mast Cell Tumor NOS, Metastatic, | |
Bone Marrow | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + M M + + + + + + M M + M + M M + M M + M M M|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 2| 4| 7| 2| 7| 7| 7| 6| 2| 6| 5| 6| 7| 7| 7| 2| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 8| 5| 3| 8| 3| 3| 3| 2| 8| 6| 1| 5| 3| 3| 3| 8| 3| 3| 5| 3| 7| 3| 3| 3|
| 6| 1| 6| 6| 1| 6| 6| 6| 7| 1| 6| 1| 2| 6| 6| 6| 1| 6| 6| 6| 6| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M + M M M M + M M M M M M M M M + M M I M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X X|
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Carcinoma, Metastatic, Liver | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | X X |
Sarcoma, Metastatic, Skin | |
Mediastinum, | |
Hepatocholangiocarcinoma, | |
Metastatic, Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 7| 2| 4| 7| 2| 7| 7| 7| 6| 2| 6| 5| 6| 7| 7| 7| 2| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 8| 5| 3| 8| 3| 3| 3| 2| 8| 6| 1| 5| 3| 3| 3| 8| 3| 3| 5| 3| 7| 3| 3| 3|
| 6| 1| 6| 6| 1| 6| 6| 6| 7| 1| 6| 1| 2| 6| 6| 6| 1| 6| 6| 6| 6| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + M + + M + + + + M + + + + + + M + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Zymbal's Gland | + + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 4| 7| 4| 7| 2| 7| 2| 7| 6| 7| 4| 7| 6| 2| 7| 4| 4| 2| 7| 5| 4| 4| 5| 3|
DAY ON TEST | 8| 5| 3| 5| 3| 8| 3| 8| 3| 9| 3| 5| 1| 0| 8| 3| 9| 5| 8| 3| 7| 5| 5| 4| 7|
| 1| 6| 6| 6| 6| 1| 6| 1| 6| 3| 6| 6| 4| 9| 1| 6| 5| 6| 1| 6| 2| 6| 6| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + A|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X|
Hepatocellular Adenoma, Multiple | X |
Hepatocholangiocarcinoma | X |
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Mesentery | + + |
Fat, Sarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Lymphoma Malignant | |
Lymphocytic | |
Acinus, Lymphoma Malignant Mixed | |
Acinus, Sarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor NOS, Metastatic, | |
Bone Marrow | X |
Sarcoma, Metastatic, Skin | X |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 4| 7| 4| 7| 2| 7| 2| 7| 6| 7| 4| 7| 6| 2| 7| 4| 4| 2| 7| 5| 4| 4| 5| 3|
DAY ON TEST | 8| 5| 3| 5| 3| 8| 3| 8| 3| 9| 3| 5| 1| 0| 8| 3| 9| 5| 8| 3| 7| 5| 5| 4| 7|
| 1| 6| 6| 6| 6| 1| 6| 1| 6| 3| 6| 6| 4| 9| 1| 6| 5| 6| 1| 6| 2| 6| 6| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
Bilateral, Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + M + + + M + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + M |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor NOS | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Mast Cell Tumor NOS, Metastatic, | |
Bone Marrow | X |
Iliac, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + M + + + + M + + + + + M +|
Mast Cell Tumor NOS, Metastatic, | |
Bone Marrow | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | I + + + + M + + + M M + M + + + M + M + + M M + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05134-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1,3-BUTADIENE Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:02:08
_____________________________________________________________________________________________________________________
| 2| 4| 7| 4| 7| 2| 7| 2| 7| 6| 7| 4| 7| 6| 2| 7| 4| 4| 2| 7| 5| 4| 4| 5| 3|
DAY ON TEST | 8| 5| 3| 5| 3| 8| 3| 8| 3| 9| 3| 5| 1| 0| 8| 3| 9| 5| 8| 3| 7| 5| 5| 4| 7|
| 1| 6| 6| 6| 6| 1| 6| 1| 6| 3| 6| 6| 4| 9| 1| 6| 5| 6| 1| 6| 2| 6| 6| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + I + + + + + + + + + + + + + + + + + + + M +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + I + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Carcinoma, Metastatic, Liver | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Skin | X |
Mediastinum, | |
Hepatocholangiocarcinoma, | |
Metastatic, Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
____________________________________________________________________________