TDMS Study 05134-02 Pathology Tables
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
CORE ANIMALS
Facility: Battelle Northwest
Chemical CAS #: 106-99-0
Lock Date: None
Cage Range: All
Reasons For Removal: 25008 Accident 25004 Dead
25009 Missing 25003 Moribund
25006 Terminal Sacrifice
Removal Date Range: 01/01/40 - 12/30/99
Treatment Groups: Include 001 CONTROL
Include 002 CONTROL
Include 003 6.25 PPM
Include 004 6.25 PPM
Include 005 20 PPM
Include 006 20 PPM
Include 007 62.5 PPM
Include 008 62.5 PPM
Include 009 200 PPM
Include 010 200 PPM
Include 011 625 PPM
Include 012 625 PPM
Page 1
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 1| 5| 3| 3|
| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1|
| 2| 3| 4| 5| 1| 2| 3| 5| 1| 4| 1| 2| 3| 4| 5| 2| 3| 5| 1| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + + M + + M M|
Acanthosis | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia | 1 |
Inflammation | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | 1 2 3 |
Inflammation, Chronic | 1 |
Inflammation, Focal, Granulomatous | 2 |
Necrosis | 1 2 |
Biliary Tract, Cyst | X |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Angiectasis | 2 1 |
Fat, Hemorrhage | |
Fat, Inflammation, Chronic | 2 2 2 |
Fat, Necrosis | 2 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 1 |
Acinus, Focal Cellular Change | 2 1 |
Acinus, Hyperplasia | 2 |
Acinus, Inflammation, Chronic | |
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 1 |
Epithelium, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 1| 5| 3| 3|
| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1|
| 2| 3| 4| 5| 1| 2| 3| 5| 1| 4| 1| 2| 3| 4| 5| 2| 3| 5| 1| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 |
Perivascular, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 1 1 |
Hypertrophy | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + M + M + M + + M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia | 3 3 2 1 1 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Inflammation | |
Follicular Cell, Hyperplasia | 1 1 1 4 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M |
__________________________________________________________________________|
Ovary | + + + + I + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Atrophy | 2 3 2 |
Cyst | X 1 X X |
Germinal Epithelium, Hyperplasia | 2 |
Granulosa Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Atrophy | |
Cyst | X |
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 1| 5| 3| 3|
| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1|
| 2| 3| 4| 5| 1| 2| 3| 5| 1| 4| 1| 2| 3| 4| 5| 2| 3| 5| 1| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia, Cystic | 3 3 3 1 3 2 3 2 2 2 2 3 3 2 2 2 3 3 2 4 2 2 3|
Inflammation | 2 |
Arteriole, Hypertrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + M + + + + + M M + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | 3 2 2 2 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + M + + + + + + M M M + + + + M + + + + M|
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia | 3 1 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M M I + M M + M + + + + M + + + + M M + + +|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 3 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Histiocytic | |
Hyperplasia | 3 1 4 2 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 2 1 2 3 2 3 2 1 2 1 1 1 2 2 2 2 3 1 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + M + + + + + +|
Hyperplasia, Lymphoid | 2 2 4 1 2 2 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 1 |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrous Osteodystrophy | 2 2 2 2 2 2 2 2 1 1 1 1 2 1 2 1 1 2 1|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 1| 5| 3| 3|
| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1|
| 2| 3| 4| 5| 1| 2| 3| 5| 1| 4| 1| 2| 3| 4| 5| 2| 3| 5| 1| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 4 |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 2 3 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Alveolus, Pigmentation, Hemosiderin | 2 |
Fat, Mediastinum, Inflammation, | |
Chronic | 2 |
Fat, Mediastinum, Necrosis | 4 |
Mediastinum, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Atrophy | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 2 |
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Suppurative | 1 |
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + I + + + +|
Inflammation | 2 3 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 3| 0| 8| 5| |
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 7| 4| 7| 1| 7| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| L |
| 3| 4| 1| 2| 4| 5| 3| 4| 2| 3| 5| 1| 2| 3| 4| 1| 2| 5| 2| 3| 4| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + + + M + M + + + + + M + + + + + + + + M +| 41 |
Acanthosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Gallbladder | A + + I + + + + + + + + A + + + + + + + + + + + +| 46 |
Hyperplasia | | 1 1.0|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + A + + + + + + + + + M + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + A + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | | 1 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X | 5 |
Hematopoietic Cell Proliferation | | 3 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Focal, Granulomatous | | 1 2.0|
Necrosis | | 2 1.5|
Biliary Tract, Cyst | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 12 |
Fat, Angiectasis | 2 | 3 1.7|
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Inflammation, Chronic | 2 | 4 2.0|
Fat, Necrosis | 2 3 1 2 2 | 8 2.3|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 4| 3 3.0|
Acinus, Focal Cellular Change | 1 | 3 1.3|
Acinus, Hyperplasia | | 1 2.0|
Acinus, Inflammation, Chronic | 2 4| 2 3.0|
Duct, Cyst | 4| 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 3 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 2 1.0|
Epithelium, Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 3| 0| 8| 5| |
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 7| 4| 7| 1| 7| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| L |
| 3| 4| 1| 2| 4| 5| 3| 4| 2| 3| 5| 1| 2| 3| 4| 1| 2| 5| 2| 3| 4| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pigmentation, Hemosiderin | 2 | 2 2.0|
Ulcer | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + + + | 4 |
Developmental Malformation | X | 1 |
Inflammation | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | +| 1 |
Inflammation | 3| 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 | 4 1.3|
Perivascular, Inflammation | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 1 | 3 1.0|
Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 2 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + I M + + + + + + + + + + + + M + M + + + +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | | 1 1.0|
Pars Distalis, Hyperplasia | 1 1 1 1 1 | 13 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Inflammation | 1 1 | 2 1.0|
Follicular Cell, Hyperplasia | 1 3 1 3 2 | 11 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 3| 0| 8| 5| |
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 7| 4| 7| 1| 7| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| L |
| 3| 4| 1| 2| 4| 5| 3| 4| 2| 3| 5| 1| 2| 3| 4| 1| 2| 5| 2| 3| 4| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Angiectasis | 1 | 4 1.8|
Atrophy | 1 | 4 2.0|
Cyst | X X X X X X X X X X | 14 1.0|
Germinal Epithelium, Hyperplasia | 1 | 2 1.5|
Granulosa Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 3 1.7|
Atrophy | 1 | 1 1.0|
Cyst | | 1 |
Dilatation | 2 | 2 2.5|
Hyperplasia, Cystic | 1 1 1 4 3 2 2 3 3 2 1 3 3 2 3 1 2 2 3 2 3 3 2| 46 2.4|
Inflammation | | 1 2.0|
Arteriole, Hypertrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + + + + M + + + + + + M + + + +| 43 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia | 2 2 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + I M + M + + + +| 39 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia | 2 2 2 2| 7 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M + + + M M + + M + M M M + M + + + M + + +| 30 |
Hematopoietic Cell Proliferation | 1 | 2 1.0|
Hyperplasia | 1 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 | 3 1.7|
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Hyperplasia, Histiocytic | 4 | 1 4.0|
Hyperplasia | 2 1 1 | 9 1.9|
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 1 1 1 1 2 1| 27 1.7|
Hyperplasia, Histiocytic | 4 | 1 4.0|
Hyperplasia, Lymphoid | 4 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + A + + + + + M + + + + + +| 46 |
Hyperplasia, Lymphoid | 1 1 | 8 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 3| 0| 8| 5| |
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 7| 4| 7| 1| 7| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| L |
| 3| 4| 1| 2| 4| 5| 3| 4| 2| 3| 5| 1| 2| 3| 4| 1| 2| 5| 2| 3| 4| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Galactocele | | 1 1.0|
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 1 |
Fibrous Osteodystrophy | 2 2 2 2 1 2 2 2 2 1 2 2 2 1 2 2 2 1 1 | 38 1.7|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 3.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1| 23 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 | 3 1.3|
Hyperplasia, Lymphoid | | 1 4.0|
Inflammation, Chronic, Focal | 1 1 2| 3 1.3|
Alveolar Epithelium, Hyperplasia | 1 2 | 5 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Alveolus, Pigmentation, Hemosiderin | | 1 2.0|
Fat, Mediastinum, Inflammation, | | |
Chronic | | 1 2.0|
Fat, Mediastinum, Necrosis | | 1 4.0|
Mediastinum, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 1 1 1 1 1 1 4 1 | 17 1.2|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2| 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 3| 0| 8| 5| |
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 7| 4| 7| 1| 7| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| L |
| 3| 4| 1| 2| 4| 5| 3| 4| 2| 3| 5| 1| 2| 3| 4| 1| 2| 5| 2| 3| 4| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 | 12 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | +| 2 |
Degeneration | 4| 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | | 2 2.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Suppurative | | 1 1.0|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 | 11 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Inflammation | | 2 2.5|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 5| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 1| 3| 3| 3| 6| 5| 3|
| 5| 5| 2| 5| 2| 5| 5| 5| 5| 2| 5| 5| 5| 5| 4| 5| 7| 2| 9| 5| 5| 5| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.25 PPM | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9|
| 2| 3| 4| 1| 2| 3| 5| 1| 3| 4| 5| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + M + + + + + + M + + + + + + + + + M +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + A A + + + + A + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + A + + + + + A + +|
Hemorrhage | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + A A + + + + + I +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + M + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + A + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + A + + + + + + + +|
Angiectasis | 2 1 2 |
Basophilic Focus | X |
Clear Cell Focus | X |
Degeneration, Fatty | 4 1 |
Eosinophilic Focus | X X X X |
Hematopoietic Cell Proliferation | 4 2 1 2 |
Inflammation, Chronic | 4 |
Inflammation, Focal, Granulomatous | 2 |
Mixed Cell Focus | |
Necrosis | 1 4 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Angiectasis | 2 |
Fat, Ectopic Tissue | |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +|
Acinus, Atrophy | 1 |
Acinus, Focal Cellular Change | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | 1 |
Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | |
Pigmentation, Hemosiderin | |
Ulcer | |
__________________________________________________________________________|
Tooth | + + + |
Inflammation | 1 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 5| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 1| 3| 3| 3| 6| 5| 3|
| 5| 5| 2| 5| 2| 5| 5| 5| 5| 2| 5| 5| 5| 5| 4| 5| 7| 2| 9| 5| 5| 5| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.25 PPM | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9|
| 2| 3| 4| 1| 2| 3| 5| 1| 3| 4| 5| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Mineralization | |
Endothelium, Hyperplasia | 1 |
Perivascular, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +|
Focal Cellular Change | 1 |
Hypertrophy | 1 |
Capsule, Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + A I + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + + + M M + + + + + M M + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 1 1 1 1 1 1 1 4 4 1|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Cyst | X X |
Follicular Cell, Hyperplasia | 1 1 3 2 2 2 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + A + + + + + + + +|
Angiectasis | 2 1 |
Atrophy | 2 3 3 2 2 2 2 3 2 2|
Cyst | X X X X X X X X X X X X X X |
Metaplasia, Osseous | |
Mineralization | 1 |
Corpus Luteum, Hyperplasia | 2|
Germinal Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 5| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 1| 3| 3| 3| 6| 5| 3|
| 5| 5| 2| 5| 2| 5| 5| 5| 5| 2| 5| 5| 5| 5| 4| 5| 7| 2| 9| 5| 5| 5| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.25 PPM | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9|
| 2| 3| 4| 1| 2| 3| 5| 1| 3| 4| 5| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + A + + + + + + + +|
Angiectasis | 2 2 2 |
Dilatation | 3 |
Hemorrhage | 3 |
Hyperplasia, Cystic | 2 4 2 2 2 2 2 3 3 4 1 4 2 2 1 3 3 2 1 3 2 3|
Inflammation | |
Arteriole, Hypertrophy | |
Cervix, Cyst | X |
Muscularis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Hyperplasia | |
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + M + + + + + + + + M + + + + + M + +|
Congestion | 2 |
Hyperplasia | 1 2 3 1 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M M + + + + M + + + + + + + + +|
Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + M M + + M + + M + M + + + M + + + M M + + M|
Angiectasis | 3 |
Congestion | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + I + + + + + + + + M + + + + + + + +|
Angiectasis | |
Congestion | |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia | 1 2 2 3 2 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 1 1 2 1 2 1 1 2 3 2 2 1 |
Hyperplasia, Lymphoid | 4 1|
Inflammation, Focal, Granulomatous | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + M + +|
Angiectasis | |
Hyperplasia, Lymphoid | 1 1 2 1 3 1 1 |
Necrosis | 2 2 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 5| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 1| 3| 3| 3| 6| 5| 3|
| 5| 5| 2| 5| 2| 5| 5| 5| 5| 2| 5| 5| 5| 5| 4| 5| 7| 2| 9| 5| 5| 5| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.25 PPM | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9|
| 2| 3| 4| 1| 2| 3| 5| 1| 3| 4| 5| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Acanthosis | |
Inflammation, Chronic | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 2 2 1 2 1 1 1 1 1 2 3 1 1 2|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1|
Perivascular, Infiltration Cellular, | |
Lymphocyte | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 2 |
Inflammation, Suppurative | 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Lymphocyte | |
Metaplasia, Osseous | |
Nephropathy | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + M + + + A + + + M + M + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| |
| 5| 5| 2| 6| 6| 8| 6| 6| 6| 6| 4| 6| 6| 5| 3| 6| 6| 0| 6| 4| 1| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
6.25 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| L |
| 2| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| 2| 3| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M M + + + + + M + + + + + M + + M| 41 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + M + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + A + + + +| 46 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + A + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 1 | 5 1.6|
Basophilic Focus | | 1 |
Clear Cell Focus | | 1 |
Degeneration, Fatty | | 2 2.5|
Eosinophilic Focus | X X X X X X X | 11 |
Hematopoietic Cell Proliferation | 1 3 | 6 2.2|
Inflammation, Chronic | | 1 4.0|
Inflammation, Focal, Granulomatous | | 1 2.0|
Mixed Cell Focus | X | 1 |
Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 13 |
Fat, Angiectasis | 2 4 | 3 2.7|
Fat, Ectopic Tissue | X | 1 |
Fat, Inflammation, Chronic | 2 2 | 3 2.3|
Fat, Necrosis | 3 3 2| 6 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 2 1 | 3 1.3|
Acinus, Focal Cellular Change | 1 1 2 1 | 5 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst Epithelial Inclusion | 3 | 1 3.0|
Ulcer | 1 | 2 1.0|
Epithelium, Hyperplasia | 2 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| |
| 5| 5| 2| 6| 6| 8| 6| 6| 6| 6| 4| 6| 6| 5| 3| 6| 6| 0| 6| 4| 1| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
6.25 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| L |
| 2| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| 2| 3| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 1 | 1 1.0|
Pigmentation, Hemosiderin | 2 2 | 2 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + | 5 |
Inflammation | 1 2 | 4 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 | 2 1.0|
Mineralization | 1 2 | 2 1.5|
Endothelium, Hyperplasia | 1 | 2 1.0|
Perivascular, Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Focal Cellular Change | 2 4 | 3 2.3|
Hypertrophy | 1 2 | 3 1.3|
Capsule, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + M + M + + + + M| 40 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 1 1 | 2 1.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hemorrhage | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 4 2 2 4 3 3 2 2 1 | 19 2.1|
Pars Intermedia, Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X X X X| 6 |
Follicular Cell, Hyperplasia | 2 1 | 10 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| |
| 5| 5| 2| 6| 6| 8| 6| 6| 6| 6| 4| 6| 6| 5| 3| 6| 6| 0| 6| 4| 1| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
6.25 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| L |
| 2| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| 2| 3| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 2 2 3 | 6 2.0|
Atrophy | 2 2 2 2 2 2 3 2 2 | 19 2.2|
Cyst | X X X X X X X X X X X X X| 27 |
Metaplasia, Osseous | 1 | 1 1.0|
Mineralization | | 1 1.0|
Corpus Luteum, Hyperplasia | | 1 2.0|
Germinal Epithelium, Hyperplasia | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 3 4 2 3| 8 2.4|
Dilatation | 3 | 2 3.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Cystic | 1 4 2 4 3 4 3 3 2 2 1 3 3 2 1 3 3 2 2 1 2 2 3 2 3| 47 2.4|
Inflammation | 3 | 1 3.0|
Arteriole, Hypertrophy | 2 | 1 2.0|
Cervix, Cyst | | 1 |
Muscularis, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pancreatic, Hyperplasia | 2 | 1 2.0|
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + I + + + + + + + M + + M + + + + + + M + + +| 42 |
Congestion | | 1 2.0|
Hyperplasia | 1 1 1 2 | 10 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + + + + + + M M + + + + + + M + + + + +| 42 |
Hyperplasia | 2 2| 5 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + M + + M M + + + M + + + M + + M M + M + + M| 29 |
Angiectasis | | 1 3.0|
Congestion | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + I + + + + + + + + + + + + + M + + + +| 46 |
Angiectasis | 1 1 | 2 1.0|
Congestion | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| |
| 5| 5| 2| 6| 6| 8| 6| 6| 6| 6| 4| 6| 6| 5| 3| 6| 6| 0| 6| 4| 1| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
6.25 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| L |
| 2| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| 2| 3| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 1 1 2 4 1 1 1 1 1 1 | 17 1.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 1 2 1 1 2 2 2 2 2 3 | 25 1.6|
Hyperplasia, Lymphoid | 2| 3 2.3|
Inflammation, Focal, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + M + + + + + +| 46 |
Angiectasis | 1 1 | 2 1.0|
Hyperplasia, Lymphoid | 2 2 2 1 2 1 1| 14 1.5|
Necrosis | 2 2 | 6 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + + + + + + + + + M + + + + + + +| 46 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Subcutaneous Tissue, Edema | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 1 1 2 1 2 1 1 2 2 2 1 1 1 1 2 1 2 3| 36 1.5|
Osteopetrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 24 1.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 2 | 4 1.3|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation, Chronic, Focal | 2 | 2 2.0|
Inflammation, Suppurative | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 3 1 1 3 | 5 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| |
| 5| 5| 2| 6| 6| 8| 6| 6| 6| 6| 4| 6| 6| 5| 3| 6| 6| 0| 6| 4| 1| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
6.25 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| L |
| 2| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| 2| 3| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 | 3 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 1 1 | 12 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 | 17 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | 1 1.0|
Infiltration Cellular, Lymphocyte | 3| 1 3.0|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 6| 1| 6| 7| 6| 7| 6| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 6| 5| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 4| 9| 7| 3| 8| 3| 9| 0| 3| 3| 5| 3| 3| 9| 3| 5| 3| 5| 6| 3| 3| 3| 4| 7|
| 4| 5| 4| 7| 4| 1| 4| 7| 7| 4| 4| 0| 3| 4| 1| 4| 3| 4| 7| 9| 4| 4| 4| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 1| 1| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8|
| 1| 2| 3| 1| 2| 4| 5| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + A + + A + + A + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
Endothelium, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + A + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Degeneration, Fatty | 1 |
Eosinophilic Focus | X X X X X X X X X |
Hematopoietic Cell Proliferation | 1 |
Infarct | 4 |
Inflammation, Focal, Granulomatous | |
Necrosis | 2 1 1 2|
__________________________________________________________________________|
Mesentery | + + + + + +|
Fat, Angiectasis | 2 3 3 |
Fat, Hemorrhage | 2|
Fat, Inflammation, Chronic | 2 3 3 |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
Acinus, Focal Cellular Change | 1 1 |
Acinus, Hyperplasia | |
Acinus, Inflammation, Chronic | 2 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Ulcer | |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 2|
Ulcer | 2|
__________________________________________________________________________|
Tooth | |
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 6| 1| 6| 7| 6| 7| 6| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 6| 5| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 4| 9| 7| 3| 8| 3| 9| 0| 3| 3| 5| 3| 3| 9| 3| 5| 3| 5| 6| 3| 3| 3| 4| 7|
| 4| 5| 4| 7| 4| 1| 4| 7| 7| 4| 4| 0| 3| 4| 1| 4| 3| 4| 7| 9| 4| 4| 4| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 1| 1| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8|
| 1| 2| 3| 1| 2| 4| 5| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Endothelium, Hyperplasia | 1 |
Perivascular, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hematopoietic Cell Proliferation | |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + M A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + M + + M + M M + + + + + M M M + + M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 1 1 2 1 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation | 2 2 |
Follicular Cell, Hyperplasia | 1 2 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3|
Cyst | X X X X X X X X |
Germinal Epithelium, Hyperplasia | 1 2 1 |
Granulosa Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 4 2 4 2 4 |
Atrophy | 1 |
Hemorrhage | 4 |
Hyperplasia, Cystic | 1 2 2 2 1 1 2 1 2 4 1 2 3 2 1 2 1 2 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 6| 1| 6| 7| 6| 7| 6| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 6| 5| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 4| 9| 7| 3| 8| 3| 9| 0| 3| 3| 5| 3| 3| 9| 3| 5| 3| 5| 6| 3| 3| 3| 4| 7|
| 4| 5| 4| 7| 4| 1| 4| 7| 7| 4| 4| 0| 3| 4| 1| 4| 3| 4| 7| 9| 4| 4| 4| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 1| 1| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8|
| 1| 2| 3| 1| 2| 4| 5| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hyperplasia | 2 2 2 3 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + M + + + + + + M M + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M M + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + A + + + M + M + M M M + + + + + + M + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 4|
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 4 2 1 3 2 2 2 2 2 4|
Hemorrhage | 4|
Hyperplasia, Lymphoid | 2 |
Capsule, Inflammation, Chronic | 3 2|
__________________________________________________________________________|
Thymus | + + + M + M + + + + + + + + + M + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | |
Necrosis | 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 |
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Necrosis | 3 |
Hair Follicle, Atrophy | 2 3 |
Subcutaneous Tissue, Hemorrhage | 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 1 1 2 2 1 2 1 2 2 1 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 6| 1| 6| 7| 6| 7| 6| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 6| 5| 7| 7| 7| 5| 5|
DAY ON TEST | 3| 4| 9| 7| 3| 8| 3| 9| 0| 3| 3| 5| 3| 3| 9| 3| 5| 3| 5| 6| 3| 3| 3| 4| 7|
| 4| 5| 4| 7| 4| 1| 4| 7| 7| 4| 4| 0| 3| 4| 1| 4| 3| 4| 7| 9| 4| 4| 4| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
20 PPM | 1| 1| 1| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8|
| 1| 2| 3| 1| 2| 4| 5| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 1| 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | 1 2 2|
Mineralization | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Mixed Cell | 2 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 4 |
Alveolus, Pigmentation, Hemosiderin | |
Fat, Mediastinum, Necrosis | |
__________________________________________________________________________|
Nose | + + + A + + + + A + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + A + + + + A + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | A |
__________________________________________________________________________|
Eye | M + |
Degeneration | |
Cornea, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Harderian Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 1|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 1 |
Nephropathy | |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 5| 4| 3| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 2| 7| 7| |
DAY ON TEST | 4| 9| 6| 0| 3| 8| 3| 7| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 4| 3| 0| 3| 7| 3| 3| |
| 1| 2| 5| 0| 4| 1| 4| 7| 4| 3| 4| 4| 6| 4| 4| 4| 5| 4| 9| 4| 4| 4| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
20 PPM | 8| 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| L |
| 3| 4| 5| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + M + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | A A + + + + + A + + + + + + + + + + A + + + A + +| 41 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + A + +| 47 |
Endothelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + + + + + + + + + A + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + A + + + + + + + + + + A + + + A + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + A + + + + + + + + + + A + + + A + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A A + + + + + + + + + + + + + + + A + + + A + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Basophilic Focus | X | 1 |
Degeneration, Fatty | | 1 1.0|
Eosinophilic Focus | X X X X X X X X X| 18 |
Hematopoietic Cell Proliferation | | 1 1.0|
Infarct | | 1 4.0|
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
Necrosis | 3 2 1 | 7 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 14 |
Fat, Angiectasis | 3 | 4 2.8|
Fat, Hemorrhage | | 1 2.0|
Fat, Inflammation, Chronic | 4 2 3 | 6 2.8|
Fat, Necrosis | 3 3 3 | 5 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + A + +| 47 |
Acinus, Atrophy | 3 3 1 2 | 5 2.2|
Acinus, Focal Cellular Change | 1 | 3 1.0|
Acinus, Hyperplasia | 1 | 1 1.0|
Acinus, Inflammation, Chronic | 3 2 | 3 2.3|
Duct, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + M + +| 47 |
Mineralization | | 1 1.0|
Ulcer | 1 | 1 1.0|
Epithelium, Hyperplasia | 1 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 5| 4| 3| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 2| 7| 7| |
DAY ON TEST | 4| 9| 6| 0| 3| 8| 3| 7| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 4| 3| 0| 3| 7| 3| 3| |
| 1| 2| 5| 0| 4| 1| 4| 7| 4| 3| 4| 4| 6| 4| 4| 4| 5| 4| 9| 4| 4| 4| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
20 PPM | 8| 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| L |
| 3| 4| 5| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Pigmentation, Hemosiderin | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 1 2.0|
Endothelium, Hyperplasia | | 1 1.0|
Perivascular, Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hypertrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + A + + + A + +| 47 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + A + +| 46 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M + + + M M + + M + M + + + M + + +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + I + + + M + + + +| 48 |
Pars Distalis, Angiectasis | 2 | 3 2.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 1 2 2 | 10 1.6|
Pars Intermedia, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 1 |
Inflammation | | 2 2.0|
Follicular Cell, Hyperplasia | 4 1 4 1 2 1 3 1| 13 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + A + + + A + +| 48 |
Angiectasis | 1 2 2| 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 5| 4| 3| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 2| 7| 7| |
DAY ON TEST | 4| 9| 6| 0| 3| 8| 3| 7| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 4| 3| 0| 3| 7| 3| 3| |
| 1| 2| 5| 0| 4| 1| 4| 7| 4| 3| 4| 4| 6| 4| 4| 4| 5| 4| 9| 4| 4| 4| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
20 PPM | 8| 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| L |
| 3| 4| 5| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | 2 2 2 2 2 1 2 2 2 2 3 3 3 3 2 3 3| 32 2.2|
Cyst | X X X X X X X X X X X | 19 |
Germinal Epithelium, Hyperplasia | 1 1 3 1 2| 8 1.5|
Granulosa Cell, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 3 2| 10 3.1|
Atrophy | | 1 1.0|
Hemorrhage | 4 | 2 4.0|
Hyperplasia, Cystic | 2 2 1 1 2 2 2 2 1 1 1 1 2 2 2 2 2 1 2 3| 40 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Fibrosis | | 1 1.0|
Hyperplasia | 2 2 2 | 9 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + M + + + + + + + M + M + +| 42 |
Hyperplasia | 2 4 2 2 2 | 6 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + M + + +| 46 |
Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + + + M M + M + + M + M + + + + + M M| 33 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Angiectasis | 1 1 | 3 1.3|
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | | 2 3.0|
Hyperplasia | 1 2 2 2 1 4 | 7 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 1 1 2 3 1 1 2 3 2 2 2 | 24 2.1|
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Capsule, Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + A + I + + + +| 45 |
Angiectasis | 2 | 1 2.0|
Hyperplasia, Lymphoid | 1 2 2 | 3 1.7|
Necrosis | 2 2 4 | 6 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 5| 4| 3| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 2| 7| 7| |
DAY ON TEST | 4| 9| 6| 0| 3| 8| 3| 7| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 4| 3| 0| 3| 7| 3| 3| |
| 1| 2| 5| 0| 4| 1| 4| 7| 4| 3| 4| 4| 6| 4| 4| 4| 5| 4| 9| 4| 4| 4| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
20 PPM | 8| 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| L |
| 3| 4| 5| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Galactocele | | 1 2.0|
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Necrosis | | 1 3.0|
Hair Follicle, Atrophy | | 2 2.5|
Subcutaneous Tissue, Hemorrhage | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 1 2 1 2 1 2 1 2 2 2 1 2 2 2| 29 1.7|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 2.0|
Hemorrhage | | 3 1.7|
Mineralization | 1 1 1 1 1 1 1 1 1 | 17 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 3 2 1 1 | 6 2.2|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Thrombosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 | 3 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 4 2 2 4 3 | 7 3.1|
Alveolus, Pigmentation, Hemosiderin | 4 3 | 2 3.5|
Fat, Mediastinum, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 1 | 13 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 | 6 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 | 14 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 5| 4| 3| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 2| 7| 7| |
DAY ON TEST | 4| 9| 6| 0| 3| 8| 3| 7| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 4| 3| 0| 3| 7| 3| 3| |
| 1| 2| 5| 0| 4| 1| 4| 7| 4| 3| 4| 4| 6| 4| 4| 4| 5| 4| 9| 4| 4| 4| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
20 PPM | 8| 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| L |
| 3| 4| 5| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Degeneration | 4 | 1 4.0|
Cornea, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Hyperplasia | 3 1 4 2 | 9 1.9|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Metaplasia, Osseous | | 2 1.0|
Nephropathy | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 6| 4| 5| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5|
DAY ON TEST | 3| 7| 4| 3| 5| 8| 3| 4| 6| 8| 5| 6| 3| 3| 2| 7| 4| 9| 1| 3| 8| 2| 3| 3| 4|
| 3| 0| 4| 3| 3| 5| 2| 9| 4| 6| 0| 5| 9| 3| 2| 0| 5| 8| 0| 9| 0| 5| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6|
| 1| 5| 1| 5| 1| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + M + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + M + + + + + M A + + + + +|
Hyperplasia | 2 |
Inflammation | 2 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + A + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + A + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Degeneration, Fatty | 2 1 2 3 |
Eosinophilic Focus | X X X X X X X |
Hematopoietic Cell Proliferation | 3 1 3 2 |
Mixed Cell Focus | X |
Necrosis | 3 1 |
Biliary Tract, Cyst | |
Biliary Tract, Hyperplasia | 1 |
Centrilobular, Degeneration, Fatty | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + +|
Fat, Angiectasis | 3 1 |
Fat, Inflammation, Chronic | 3 3|
Fat, Necrosis | 4 2 4|
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + A + + + + + + + + + + + +|
Acinus, Focal Cellular Change | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + A + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Inflammation | 1 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + A + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + + + A + + + + + + + + + + + +|
Ulcer | 2 |
Epithelium, Hyperplasia | 2 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + A + + + + + + + + + + + +|
Mineralization | |
Pigmentation, Hemosiderin | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 6| 4| 5| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5|
DAY ON TEST | 3| 7| 4| 3| 5| 8| 3| 4| 6| 8| 5| 6| 3| 3| 2| 7| 4| 9| 1| 3| 8| 2| 3| 3| 4|
| 3| 0| 4| 3| 3| 5| 2| 9| 4| 6| 0| 5| 9| 3| 2| 0| 5| 8| 0| 9| 0| 5| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6|
| 1| 5| 1| 5| 1| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + A + + + + + + + + + + + +|
Cardiomyopathy | 2 2 |
Mineralization | 1 |
Necrosis | 1 |
Endothelium, Hyperplasia | 2 |
Pericardium, Inflammation, Chronic | 1 |
Pericardium, Fat, Necrosis | |
Perivascular, Inflammation | 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + A + + + + + + + + + + + +|
Cyst | X X X |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 2 |
Hypertrophy | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + A + + + + A + I + + I + + + + + + +|
Cyst | X |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + A + + + + + + + I + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M + M A M M + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + I + + + + M + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + A + + + + + + + + + + + +|
Cyst | 4 |
Inflammation | 2 |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 3 4 |
Atrophy | 2 3 2 2 1 2 3 3 2 2 3 2 2 2 3 2 3 3 1 3|
Cyst | X X X X X X X X X |
Germinal Epithelium, Hyperplasia | 3 2 1 3 2 2 1 1 |
Granulosa Cell, Hyperplasia | 1 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + A + + + + + + + + + + + +|
Angiectasis | 1 3 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 6| 4| 5| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5|
DAY ON TEST | 3| 7| 4| 3| 5| 8| 3| 4| 6| 8| 5| 6| 3| 3| 2| 7| 4| 9| 1| 3| 8| 2| 3| 3| 4|
| 3| 0| 4| 3| 3| 5| 2| 9| 4| 6| 0| 5| 9| 3| 2| 0| 5| 8| 0| 9| 0| 5| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6|
| 1| 5| 1| 5| 1| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 1 |
Cyst | |
Hemorrhage | 2 |
Hyperplasia, Cystic | 1 1 1 2 1 3 1 1 1 2 2 2 1 1 1 1 2 2 1 2|
Thrombosis | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + A + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | |
Hyperplasia | 2 3 2 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M + + + + + M M + + + + M M + + + M + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | |
Inflammation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + A + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 3 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + + + M M M + + A M + + M + + + M M + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + + M + + + + + + + + + + + + + +|
Angiectasis | 4 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + A + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 4 2 1 4 2 2 2 2 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + M A + M + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | |
Necrosis | 2 1 2 2 2 1 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 1 |
Hyperplasia | 2 4 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hair Follicle, Atrophy | 2 1 |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 6| 4| 5| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5|
DAY ON TEST | 3| 7| 4| 3| 5| 8| 3| 4| 6| 8| 5| 6| 3| 3| 2| 7| 4| 9| 1| 3| 8| 2| 3| 3| 4|
| 3| 0| 4| 3| 3| 5| 2| 9| 4| 6| 0| 5| 9| 3| 2| 0| 5| 8| 0| 9| 0| 5| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6|
| 1| 5| 1| 5| 1| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 1 1 1 2 2 2 3 2 2 3 1 2 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Mineralization | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + A + + + + + + + + + I + +|
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
Inflammation, Chronic, Focal | |
Inflammation, Focal, Granulomatous | |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 2 2 2 1 4 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 3 1 |
Alveolus, Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cornea, Hyperplasia | 2 |
Cornea, Inflammation, Chronic | 3 |
Lens, Degeneration | 3 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Nephropathy | 1 1 1 1|
Pigmentation, Hemosiderin | 2 3 |
Renal Tubule, Degeneration | |
Renal Tubule, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 6| 4| 5| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5|
DAY ON TEST | 3| 7| 4| 3| 5| 8| 3| 4| 6| 8| 5| 6| 3| 3| 2| 7| 4| 9| 1| 3| 8| 2| 3| 3| 4|
| 3| 0| 4| 3| 3| 5| 2| 9| 4| 6| 0| 5| 9| 3| 2| 0| 5| 8| 0| 9| 0| 5| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
62.5 PPM | 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6|
| 1| 5| 1| 5| 1| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + A + + + + + + I + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 4| 3| 6| 4| 6| 6| 7| 5| 7| 5| 5| 5| 4| 7| 5| 6| 3| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 8| 0| 9| 0| 4| 5| 2| 2| 6| 3| 9| 7| 9| 4| 3| 2| 5| 8| 0| 9| 3| 3| 3| |
| 8| 3| 5| 7| 2| 8| 3| 8| 5| 3| 9| 3| 4| 9| 7| 3| 3| 4| 3| 7| 7| 8| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
62.5 PPM | 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| L |
| 3| 5| 1| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + M + + + + + + + + + M + + + + +| 45 |
__________________________________________________________________________|____________|
Gallbladder | I + + + + + + + + + + + + + + + + A + + M + + + +| 43 |
Hyperplasia | 2 1 | 3 1.7|
Inflammation | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 4| 3 2.7|
Basophilic Focus | X | 2 |
Degeneration, Fatty | | 4 2.0|
Eosinophilic Focus | X 1 X X | 11 1.0|
Hematopoietic Cell Proliferation | 3 1 1 1 3 3 1 | 11 2.0|
Mixed Cell Focus | | 1 |
Necrosis | 1 2 2 | 5 1.8|
Biliary Tract, Cyst | X | 1 |
Biliary Tract, Hyperplasia | | 1 1.0|
Centrilobular, Degeneration, Fatty | 2 | 1 2.0|
Centrilobular, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 9 |
Fat, Angiectasis | 3 | 3 2.3|
Fat, Inflammation, Chronic | | 2 3.0|
Fat, Necrosis | | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Focal Cellular Change | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy, Focal | | 1 2.0|
Inflammation | 1 | 4 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ulcer | 1 1 | 3 1.3|
Epithelium, Hyperplasia | 3 4 2 2 | 7 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 4| 3| 6| 4| 6| 6| 7| 5| 7| 5| 5| 5| 4| 7| 5| 6| 3| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 8| 0| 9| 0| 4| 5| 2| 2| 6| 3| 9| 7| 9| 4| 3| 2| 5| 8| 0| 9| 3| 3| 3| |
| 8| 3| 5| 7| 2| 8| 3| 8| 5| 3| 9| 3| 4| 9| 7| 3| 3| 4| 3| 7| 7| 8| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
62.5 PPM | 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| L |
| 3| 5| 1| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Pigmentation, Hemosiderin | 2 | 2 2.0|
Ulcer | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 1 2 | 4 1.8|
Mineralization | 1 | 2 1.0|
Necrosis | 2 | 2 1.5|
Endothelium, Hyperplasia | 2 4 1 | 4 2.3|
Pericardium, Inflammation, Chronic | | 1 1.0|
Pericardium, Fat, Necrosis | 3 | 1 3.0|
Perivascular, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 4 |
Hematopoietic Cell Proliferation | 3 2 2 | 4 2.3|
Hyperplasia | | 2 2.0|
Hypertrophy | 1| 3 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + I + + + + + + + +| 45 |
Cyst | | 1 |
Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M + + + + + + + + + + + M M + + +| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 4 1 1 3 2 1 | 9 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X X X | 4 4.0|
Inflammation | 2 | 2 2.0|
C-Cell, Hyperplasia | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 1 1 1 | 6 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 4| 3| 6| 4| 6| 6| 7| 5| 7| 5| 5| 5| 4| 7| 5| 6| 3| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 8| 0| 9| 0| 4| 5| 2| 2| 6| 3| 9| 7| 9| 4| 3| 2| 5| 8| 0| 9| 3| 3| 3| |
| 8| 3| 5| 7| 2| 8| 3| 8| 5| 3| 9| 3| 4| 9| 7| 3| 3| 4| 3| 7| 7| 8| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
62.5 PPM | 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| L |
| 3| 5| 1| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 2 1 1 3 4 4 | 13 2.4|
Atrophy | 3 3 2 3 2 2 3 2 3 3 2 3 3 2 3 3 2 1 2 3 3 3| 42 2.4|
Cyst | X X X X X X X X | 17 |
Germinal Epithelium, Hyperplasia | 2 3 1 2 1 3 1 | 15 1.9|
Granulosa Cell, Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 4 4 4 | 5 3.2|
Atrophy | | 1 1.0|
Cyst | X | 1 |
Hemorrhage | | 1 2.0|
Hyperplasia, Cystic | 1 1 1 1 1 1 3 2 2 3 1 1 2 1 4 1 1 1 2 2| 40 1.5|
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + + + | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Fibrosis | 2 | 1 2.0|
Hyperplasia | 3 3 2 2 2 2 3 3 2 3 2 2 | 18 2.4|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + + + + + M + + + M + + + + + + + M + + + +| 38 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hyperplasia | 2 | 1 2.0|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + I + + + + + + M + + M + M + + + +| 43 |
Hematopoietic Cell Proliferation | 2 2 | 3 2.0|
Hyperplasia | 2 3 | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + + M + + + M + M| 36 |
Hematopoietic Cell Proliferation | 1 3 4 | 3 2.7|
Hyperplasia | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 2 | 4 2.5|
Hematopoietic Cell Proliferation | 1 3 2 | 3 2.0|
Hyperplasia | 2 2| 6 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 4| 3| 6| 4| 6| 6| 7| 5| 7| 5| 5| 5| 4| 7| 5| 6| 3| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 8| 0| 9| 0| 4| 5| 2| 2| 6| 3| 9| 7| 9| 4| 3| 2| 5| 8| 0| 9| 3| 3| 3| |
| 8| 3| 5| 7| 2| 8| 3| 8| 5| 3| 9| 3| 4| 9| 7| 3| 3| 4| 3| 7| 7| 8| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
62.5 PPM | 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| L |
| 3| 5| 1| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 3 4 2 3 2 1 1 2 4 3 3 2 2 2 2 2 2| 29 2.3|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M M M + + + + + + + + + I I + + + +| 41 |
Hyperplasia, Lymphoid | 4 | 2 3.0|
Infiltration Cellular, Mixed Cell | 4 | 1 4.0|
Necrosis | 2 2 1 2 2 | 16 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 1.0|
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hair Follicle, Atrophy | 3 | 3 2.0|
Subcutaneous Tissue, Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 2 2 1 1 2 2| 22 1.8|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 | 3 1.3|
Mineralization | 1 1 1 1 1 1 1 | 14 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + I + +| 47 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 2 | 5 2.2|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
Inflammation, Suppurative | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 | 9 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 4 2 | 7 2.4|
Alveolus, Pigmentation, Hemosiderin | 2 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 | 11 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 4| 3| 6| 4| 6| 6| 7| 5| 7| 5| 5| 5| 4| 7| 5| 6| 3| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 8| 0| 9| 0| 4| 5| 2| 2| 6| 3| 9| 7| 9| 4| 3| 2| 5| 8| 0| 9| 3| 3| 3| |
| 8| 3| 5| 7| 2| 8| 3| 8| 5| 3| 9| 3| 4| 9| 7| 3| 3| 4| 3| 7| 7| 8| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
62.5 PPM | 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| L |
| 3| 5| 1| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 1 1| 10 1.1|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Hyperplasia | | 1 2.0|
Cornea, Inflammation, Chronic | | 1 3.0|
Lens, Degeneration | | 2 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 1 | 2 1.5|
Nephropathy | 2 2 | 6 1.3|
Pigmentation, Hemosiderin | | 2 2.5|
Renal Tubule, Degeneration | 2 | 1 2.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
Renal Tubule, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 5| 5| 4| 3| 4| 4| 4| 6| 4| 5| 3| 5| 5| 5| 4| 4| 3| 5| 5| 6| 5| 4| 4| 4| 3|
DAY ON TEST | 6| 0| 6| 9| 7| 8| 5| 2| 6| 1| 7| 9| 9| 6| 1| 5| 5| 6| 6| 6| 0| 7| 8| 6| 7|
| 9| 2| 0| 3| 1| 5| 4| 9| 3| 3| 1| 7| 7| 9| 1| 4| 3| 9| 9| 3| 2| 2| 5| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4|
| 1| 3| 1| 2| 3| 5| 3| 4| 5| 1| 2| 3| 1| 2| 3| 5| 2| 3| 4| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + A + + + + + + + A + + + + + + A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | 1 1 1 4 2 2 1 |
Necrosis | 2 2 1 1 3 2 1 1 2 2 2 |
Thrombosis | |
Biliary Tract, Cyst | |
Centrilobular, Degeneration, Fatty | |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Angiectasis | |
Fat, Hemorrhage | |
Fat, Inflammation, Chronic | 3 2 3 |
Fat, Necrosis | 2 2 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 1 |
Epithelium, Hyperplasia | 1 1 3 1 1 1 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 3 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 3 |
Mineralization | 1 1 |
Necrosis | |
Endothelium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 5| 5| 4| 3| 4| 4| 4| 6| 4| 5| 3| 5| 5| 5| 4| 4| 3| 5| 5| 6| 5| 4| 4| 4| 3|
DAY ON TEST | 6| 0| 6| 9| 7| 8| 5| 2| 6| 1| 7| 9| 9| 6| 1| 5| 5| 6| 6| 6| 0| 7| 8| 6| 7|
| 9| 2| 0| 3| 1| 5| 4| 9| 3| 3| 1| 7| 7| 9| 1| 4| 3| 9| 9| 3| 2| 2| 5| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4|
| 1| 3| 1| 2| 3| 5| 3| 4| 5| 1| 2| 3| 1| 2| 3| 5| 2| 3| 4| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hematocyst | |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia | 1 |
Hypertrophy | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + M + + M + M + + M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 2 1 1 4 |
Atrophy | 2 2 3 3 3 3 3 3 3 2 3 3 2 3 3 3 3 3 3 3 3 3|
Cyst | X X X X X |
Germinal Epithelium, Hyperplasia | 2 3 1 1 3 2 1 3 |
Granulosa Cell, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 2 1 1 |
Hyperplasia, Cystic | 1 2 2 1 1 1 2 2 1 1 |
Muscularis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 2 4 3 3 3 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M M M + + + M + + + + + + M + + + M + I + M +|
Congestion | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M + + + + + I + + + + + + + + M + M + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 5| 5| 4| 3| 4| 4| 4| 6| 4| 5| 3| 5| 5| 5| 4| 4| 3| 5| 5| 6| 5| 4| 4| 4| 3|
DAY ON TEST | 6| 0| 6| 9| 7| 8| 5| 2| 6| 1| 7| 9| 9| 6| 1| 5| 5| 6| 6| 6| 0| 7| 8| 6| 7|
| 9| 2| 0| 3| 1| 5| 4| 9| 3| 3| 1| 7| 7| 9| 1| 4| 3| 9| 9| 3| 2| 2| 5| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4|
| 1| 3| 1| 2| 3| 5| 3| 4| 5| 1| 2| 3| 1| 2| 3| 5| 2| 3| 4| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + I + + + + + + + + + + + M + + + + + M M + + + +|
Congestion | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 3 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + M +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia | |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 3 2 2 2 2 2 4 3 2 3 3 2 |
Necrosis | |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | I + + + M + + M + + + + + + + M + + + + + + M + +|
Infiltration Cellular, Mixed Cell | 4 |
Necrosis | 2 2 1 3 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Necrosis | 2 |
Subcutaneous Tissue, Hemorrhage | 2 |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 1 1 2 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Mineralization | |
Necrosis | 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 5| 5| 4| 3| 4| 4| 4| 6| 4| 5| 3| 5| 5| 5| 4| 4| 3| 5| 5| 6| 5| 4| 4| 4| 3|
DAY ON TEST | 6| 0| 6| 9| 7| 8| 5| 2| 6| 1| 7| 9| 9| 6| 1| 5| 5| 6| 6| 6| 0| 7| 8| 6| 7|
| 9| 2| 0| 3| 1| 5| 4| 9| 3| 3| 1| 7| 7| 9| 1| 4| 3| 9| 9| 3| 2| 2| 5| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4|
| 1| 3| 1| 2| 3| 5| 3| 4| 5| 1| 2| 3| 1| 2| 3| 5| 2| 3| 4| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic, Diffuse | 2 |
Inflammation, Chronic, Focal | |
Inflammation, Suppurative | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 2 1 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 3 3 3 3 3|
Alveolus, Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cornea, Hyperplasia | 3 |
Cornea, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hematopoietic Cell Proliferation | |
Hydronephrosis | 2 3 |
Infarct | 3 |
Inflammation, Suppurative | |
Metaplasia, Osseous | 1 1 |
Nephropathy | |
Capsule, Inflammation, Chronic | 1 |
Medulla, Congestion | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 5| 5| 6| 0| 7| 5| 4| 4| 4| 4| 6| 3| 4| 3| 5| 5| 2| 5| 4| 3| 3| 3| |
DAY ON TEST | 0| 1| 0| 2| 3| 2| 0| 0| 0| 8| 3| 4| 7| 9| 7| 7| 8| 4| 0| 6| 6| 8| 4| 1| 4| |
| 8| 8| 5| 4| 2| 4| 9| 4| 9| 4| 6| 6| 0| 5| 0| 8| 6| 3| 9| 8| 9| 9| 3| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| A |
200 PPM | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| L |
| 3| 4| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 5| 2| 3| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M M + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | A + + + + + A A + + A + + + + + + A + + + + A + A| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A A + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | I + + + + + A A + + + + + + + + M A + + + + A + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | I + + + + + A + + + A + + + + + + A + + + + + + +| 45 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + A A + + + + + + A + + + + A + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Eosinophilic Focus | X X | 5 |
Hematopoietic Cell Proliferation | 1 2 3 4 1 4 4| 14 2.2|
Necrosis | 3 2 3 1 3 1 2 2| 19 1.9|
Thrombosis | 3 | 1 3.0|
Biliary Tract, Cyst | X | 1 |
Centrilobular, Degeneration, Fatty | 2 | 1 2.0|
Centrilobular, Necrosis | 1 2 3 | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 12 |
Fat, Angiectasis | 4 | 1 4.0|
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Inflammation, Chronic | 4 3 | 5 3.0|
Fat, Necrosis | 2 4 | 6 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 1 2 | 2 1.5|
Acinus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 1 2 2 | 5 1.4|
Epithelium, Hyperplasia | 2 1 1 1 3 2 | 14 1.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Pigmentation, Hemosiderin | 2 2 2 1| 5 2.0|
Ulcer | 2 1 2 2 2| 6 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 5| 5| 6| 0| 7| 5| 4| 4| 4| 4| 6| 3| 4| 3| 5| 5| 2| 5| 4| 3| 3| 3| |
DAY ON TEST | 0| 1| 0| 2| 3| 2| 0| 0| 0| 8| 3| 4| 7| 9| 7| 7| 8| 4| 0| 6| 6| 8| 4| 1| 4| |
| 8| 8| 5| 4| 2| 4| 9| 4| 9| 4| 6| 6| 0| 5| 0| 8| 6| 3| 9| 8| 9| 9| 3| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| A |
200 PPM | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| L |
| 3| 4| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 5| 2| 3| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Infiltration Cellular, Mixed Cell | | 1 3.0|
Mineralization | | 2 1.0|
Necrosis | 2 | 1 2.0|
Endothelium, Hyperplasia | 1 4 3 | 5 2.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Hematocyst | X | 1 |
Hematopoietic Cell Proliferation | 2 3 1 | 5 2.0|
Hyperplasia | | 1 1.0|
Hypertrophy | | 2 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + M + + + I + M + + + + + M + + + + + +| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Pars Distalis, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 2 3 1 2 2 4| 14 2.1|
Atrophy | 3 3 3 3 3 3 3 3 3 3 2 3 2 3 3 2 3 2 3 3 2| 43 2.8|
Cyst | X X X X | 9 |
Germinal Epithelium, Hyperplasia | 1 2 3 3 2 1 | 14 2.0|
Granulosa Cell, Hyperplasia | 3 | 4 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 4 | 2 4.0|
Atrophy | 2 2 1 1 1 | 8 1.4|
Hyperplasia, Cystic | 1 2 3 1 1 1 1 1 | 18 1.4|
Muscularis, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 5| 5| 6| 0| 7| 5| 4| 4| 4| 4| 6| 3| 4| 3| 5| 5| 2| 5| 4| 3| 3| 3| |
DAY ON TEST | 0| 1| 0| 2| 3| 2| 0| 0| 0| 8| 3| 4| 7| 9| 7| 7| 8| 4| 0| 6| 6| 8| 4| 1| 4| |
| 8| 8| 5| 4| 2| 4| 9| 4| 9| 4| 6| 6| 0| 5| 0| 8| 6| 3| 9| 8| 9| 9| 3| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| A |
200 PPM | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| L |
| 3| 4| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 5| 2| 3| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 3 2 4 2 3 | 17 2.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Renal, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + M + M + M + M + M + M M + + + + + + +| 34 |
Congestion | 3| 1 3.0|
Hematopoietic Cell Proliferation | 4 | 2 3.5|
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + M + M I M + + M + +| 39 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M M + M + + + + M + + + + + + + + M + M| 40 |
Congestion | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 3 3 | 2 3.0|
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 3| 2 3.5|
Hyperplasia | 2 | 1 2.0|
Inflammation, Granulomatous | 4 | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 2 4 2 3 2 2 2 4 2 3 2 2| 25 2.5|
Necrosis | 2 | 1 2.0|
Capsule, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + M + + M M + + + + I + + +| 40 |
Infiltration Cellular, Mixed Cell | | 1 4.0|
Necrosis | 2 2 2 3 1 1 2 2 2 3 2| 21 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + A + + + + + + + + + M + + + + + + + +| 47 |
Hyperplasia | 1 2 2 1 | 7 1.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 4 | 2 3.5|
Necrosis | | 1 2.0|
Subcutaneous Tissue, Hemorrhage | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 5| 5| 6| 0| 7| 5| 4| 4| 4| 4| 6| 3| 4| 3| 5| 5| 2| 5| 4| 3| 3| 3| |
DAY ON TEST | 0| 1| 0| 2| 3| 2| 0| 0| 0| 8| 3| 4| 7| 9| 7| 7| 8| 4| 0| 6| 6| 8| 4| 1| 4| |
| 8| 8| 5| 4| 2| 4| 9| 4| 9| 4| 6| 6| 0| 5| 0| 8| 6| 3| 9| 8| 9| 9| 3| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| A |
200 PPM | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| L |
| 3| 4| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 5| 2| 3| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 2 2 1 1 | 11 1.3|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 2 1.0|
Mineralization | 1 1 1 1 1| 5 1.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 2 2 2 1 2 2| 10 1.9|
Infiltration Cellular, Mixed Cell | 2 | 2 2.0|
Inflammation, Chronic, Diffuse | | 1 2.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 2 4 1| 11 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 4 3 2 | 10 2.9|
Alveolus, Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 2| 7 1.1|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 1.0|
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1| 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 | 8 1.0|
Metaplasia, Squamous | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
__________________________________________________________________________|____________|
Eye | + + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 5| 5| 6| 0| 7| 5| 4| 4| 4| 4| 6| 3| 4| 3| 5| 5| 2| 5| 4| 3| 3| 3| |
DAY ON TEST | 0| 1| 0| 2| 3| 2| 0| 0| 0| 8| 3| 4| 7| 9| 7| 7| 8| 4| 0| 6| 6| 8| 4| 1| 4| |
| 8| 8| 5| 4| 2| 4| 9| 4| 9| 4| 6| 6| 0| 5| 0| 8| 6| 3| 9| 8| 9| 9| 3| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| A |
200 PPM | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| L |
| 3| 4| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 5| 2| 3| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cornea, Hyperplasia | | 1 3.0|
Cornea, Inflammation, Chronic | 1 | 2 1.5|
__________________________________________________________________________|____________|
Harderian Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 4 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 2 2| 2 2.0|
Hydronephrosis | | 2 2.5|
Infarct | | 1 3.0|
Inflammation, Suppurative | 1 | 1 1.0|
Metaplasia, Osseous | | 2 1.0|
Nephropathy | 2 | 1 2.0|
Capsule, Inflammation, Chronic | | 1 1.0|
Medulla, Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 3| 2| 3| 2| 2| 2| 1| 3|
DAY ON TEST | 5| 4| 0| 9| 7| 1| 9| 2| 1| 1| 3| 8| 2| 0| 8| 1| 4| 7| 0| 8| 0| 8| 5| 8| 3|
| 3| 0| 7| 4| 5| 7| 8| 8| 7| 9| 1| 0| 9| 7| 7| 9| 3| 9| 5| 5| 3| 5| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + A A + + + + A + A + + + + + + M + + + + A +|
Inflammation | |
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + + + + + + A + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + A + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small | + + + A A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + A A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + + + + A + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A A + + + + A + + + + + + + + + + + + + A +|
Hemorrhage | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 1 1 2 |
Inflammation, Chronic | |
Mixed Cell Focus | X |
Necrosis | 1 2 2 2 2 1 |
Thrombosis | |
Biliary Tract, Cyst | |
Centrilobular, Degeneration, Fatty | 3 3|
Centrilobular, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +|
Acinus, Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
Ulcer | 1 2 |
Epithelium, Hyperplasia | 3 3 2 2 2 3 2 2 2 3 3 2 1 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A +|
Hemorrhage | 2 |
Pigmentation, Hemosiderin | 1 |
Ulcer | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 3| 2| 3| 2| 2| 2| 1| 3|
DAY ON TEST | 5| 4| 0| 9| 7| 1| 9| 2| 1| 1| 3| 8| 2| 0| 8| 1| 4| 7| 0| 8| 0| 8| 5| 8| 3|
| 3| 0| 7| 4| 5| 7| 8| 8| 7| 9| 1| 0| 9| 7| 7| 9| 3| 9| 5| 5| 3| 5| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | 1 1 1 1 |
Necrosis | 2 |
Atrium, Thrombosis | |
Endothelium, Hyperplasia | 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + M M + + + + + M + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + M + + I + + + + + + + + + + M + I + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + A +|
Angiectasis | 3 1 1 2 |
Atrophy | 2 2 2 3 3 2 3 2 3 3 2 3 3 3 3 2 3 2 3 3|
Cyst | X X X X |
Germinal Epithelium, Hyperplasia | 1 3 1 1 |
Granulosa Cell, Hyperplasia | 2 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + A +|
Atrophy | 2 2 2 1 2 2 1 2 2 2 1 2 1 |
Cyst | |
Hyperplasia, Histiocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +|
Atrophy | 4 4 4 4|
Hyperplasia | 3 2 3 3 3 2 |
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M M + M + + M + + M M M M M M + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 3| 2| 3| 2| 2| 2| 1| 3|
DAY ON TEST | 5| 4| 0| 9| 7| 1| 9| 2| 1| 1| 3| 8| 2| 0| 8| 1| 4| 7| 0| 8| 0| 8| 5| 8| 3|
| 3| 0| 7| 4| 5| 7| 8| 8| 7| 9| 1| 0| 9| 7| 7| 9| 3| 9| 5| 5| 3| 5| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + M + + I + I + + I + + + + + +|
Hyperplasia, Histiocytic | 2|
Hyperplasia, Plasma Cell | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M + + + M + + + M + + M + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + + + + + + M M + + + + A +|
Congestion | |
Hemorrhage | 1 |
Hyperplasia, Histiocytic | 2|
Inflammation | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 2 2 2 3 3 2 2 |
Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Thymus | + + + + + + I + + + M + + + + + + M + + + + + + +|
Necrosis | 2 2 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + A +|
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periosteum, Hemorrhage | |
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Infiltration Cellular, Mixed Cell | |
Mineralization | 1 1 1 1|
Thrombosis | |
Ventricle, Cyst Epithelial Inclusion | |
__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 3| 2| 3| 2| 2| 2| 1| 3|
DAY ON TEST | 5| 4| 0| 9| 7| 1| 9| 2| 1| 1| 3| 8| 2| 0| 8| 1| 4| 7| 0| 8| 0| 8| 5| 8| 3|
| 3| 0| 7| 4| 5| 7| 8| 8| 7| 9| 1| 0| 9| 7| 7| 9| 3| 9| 5| 5| 3| 5| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hemorrhage | 2 1 2 3 1 |
Infiltration Cellular, Mixed Cell | 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Peribronchiolar, Inflammation, | |
Pyogranulomatous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Suppurative | |
Olfactory Epithelium, Atrophy | 2 3 4 |
Olfactory Epithelium, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + A + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + M + + + + + + + + + + + + + + + + M + M + I I +|
Hyperplasia | 1 1 1|
Inflammation, Chronic | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | 3 |
Metaplasia, Osseous | |
Thrombosis | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + A +|
Hemorrhage | |
Hyperplasia, Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2| 4| 3| 3| 3|
DAY ON TEST | 2| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7| 0| 8| 4| 3|
| 5| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5| 1| 7| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + I A + + I + + + A + A + + A + A A A + + + + M +|
Inflammation | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + A + + + A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + A + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + A + + + + + + + + M + + A A + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A M + + A + A + A + A + + A + + A + + + + + A +|
Hemorrhage | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 2 1 |
Inflammation, Chronic | |
Mixed Cell Focus | |
Necrosis | 2 2 3 2 3 1 4 |
Thrombosis | 3 |
Biliary Tract, Cyst | X X |
Centrilobular, Degeneration, Fatty | |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 1 1 1 |
Epithelium, Hyperplasia | 2 2 2 2 4 3 3 2 2 2 1 2 1 2 1 2 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hemorrhage | |
Pigmentation, Hemosiderin | 2 |
Ulcer | 1 |
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 3 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2| 4| 3| 3| 3|
DAY ON TEST | 2| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7| 0| 8| 4| 3|
| 5| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5| 1| 7| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | 1 1 |
Necrosis | 2 |
Atrium, Thrombosis | |
Endothelium, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 |
Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + M + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + I + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 4 1 2 1 |
Atrophy | 3 3 3 3 3 2 3 3 3 2 2 2 2 2 3 3 3 4 3 2 3 3 3 3|
Cyst | X X X X X X |
Germinal Epithelium, Hyperplasia | 2 1 1 3 1|
Granulosa Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 2 1 3 1 1 2 2 2 1 2 2|
Cyst | |
Hyperplasia, Histiocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 |
Hyperplasia | 3 4 2 3 2 |
Necrosis | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + M + + + + + + + + + + M M + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2| 4| 3| 3| 3|
DAY ON TEST | 2| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7| 0| 8| 4| 3|
| 5| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5| 1| 7| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + M M I M + + + + + + + + + + + M + + M + +|
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Plasma Cell | |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + M + + + M M + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Histiocytic | |
Inflammation | |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 2 2 2 4 2 2 2 3 |
Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Thymus | + + M + + + + + M + + + + + + + + + + + + + + + +|
Necrosis | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periosteum, Hemorrhage | |
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Mixed Cell | 2 |
Mineralization | 1 1 1 |
Thrombosis | |
Ventricle, Cyst Epithelial Inclusion | X |
__________________________________________________________________________|
Spinal Cord | + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2| 4| 3| 3| 3|
DAY ON TEST | 2| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7| 0| 8| 4| 3|
| 5| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5| 1| 7| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
625 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + A + + + + + I + + + + I + + + + + + + + + + I +|
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Mixed Cell | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 3 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 |
Peribronchiolar, Inflammation, | |
Pyogranulomatous | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Olfactory Epithelium, Atrophy | 3 4 |
Olfactory Epithelium, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + M + + M + + M + + + + + + + + +|
Hyperplasia | 1 3 |
Inflammation, Chronic | 3|
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Metaplasia, Osseous | 1 |
Thrombosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 2| 2| 2| 0| 3| 2| 3| 2| 4| 3| 2| 4| 4| 2| 3| 3| 3| 3| 3| 2| 3| 4| 2| 3| 3|
DAY ON TEST | 8| 7| 2| 1| 9| 8| 0| 4| 2| 5| 5| 2| 1| 9| 2| 7| 6| 1| 5| 5| 1| 1| 3| 7| 1|
| 5| 2| 1| 1| 2| 0| 0| 6| 5| 6| 3| 5| 8| 6| 9| 3| 7| 6| 7| 7| 6| 8| 0| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
625 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5|
| 1| 2| 3| 4| 2| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + A A + + A A + A A + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + A A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A A + A A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + M + + + A A + + A A + A A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + A A + A A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + A + A A + A A + + + + + + + +|
Hemorrhage | 1 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X|
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 2 1 1 1 |
Inflammation, Chronic | 2 |
Mixed Cell Focus | |
Necrosis | 3 2 2 |
Thrombosis | |
Biliary Tract, Cyst | |
Centrilobular, Degeneration, Fatty | 2 |
Centrilobular, Necrosis | 2 2 3 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Acinus, Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 2 1 2 |
Epithelium, Hyperplasia | 1 1 1 2 3 3 1 2 4 1 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hemorrhage | |
Pigmentation, Hemosiderin | 2 2 |
Ulcer | 2 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 2| 2| 2| 0| 3| 2| 3| 2| 4| 3| 2| 4| 4| 2| 3| 3| 3| 3| 3| 2| 3| 4| 2| 3| 3|
DAY ON TEST | 8| 7| 2| 1| 9| 8| 0| 4| 2| 5| 5| 2| 1| 9| 2| 7| 6| 1| 5| 5| 1| 1| 3| 7| 1|
| 5| 2| 1| 1| 2| 0| 0| 6| 5| 6| 3| 5| 8| 6| 9| 3| 7| 6| 7| 7| 6| 8| 0| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
625 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5|
| 1| 2| 3| 4| 2| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | 2 1 1 2 2 |
Necrosis | 1 |
Atrium, Thrombosis | 2 4 |
Endothelium, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + A + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + M + + + + + M M + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + I + + + + + + + + + + + A + + + + + + + + + + I|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 3 1 2 |
Atrophy | 3 3 2 3 3 2 3 3 3 3 4 2 3 3 3 3 3 2 3 3 3|
Cyst | X X X |
Germinal Epithelium, Hyperplasia | 2 2 2 2 2 2 1 |
Granulosa Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy | 2 2 2 2 1 2 2 1 1 1 1 2|
Cyst | X |
Hyperplasia, Histiocytic | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | M |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 4 3 3 |
Hyperplasia | 1 2 2 2 3 |
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + M + + M + + + + + + M M + M M + M M M +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 2| 2| 2| 0| 3| 2| 3| 2| 4| 3| 2| 4| 4| 2| 3| 3| 3| 3| 3| 2| 3| 4| 2| 3| 3|
DAY ON TEST | 8| 7| 2| 1| 9| 8| 0| 4| 2| 5| 5| 2| 1| 9| 2| 7| 6| 1| 5| 5| 1| 1| 3| 7| 1|
| 5| 2| 1| 1| 2| 0| 0| 6| 5| 6| 3| 5| 8| 6| 9| 3| 7| 6| 7| 7| 6| 8| 0| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
625 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5|
| 1| 2| 3| 4| 2| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + M + + + M + + M + A + M + M I + + + + I +|
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Plasma Cell | |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + M + + + + + + + + + M + + + + M M + +|
Congestion | 2 3 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + + A + + + + + + + + M M +|
Congestion | 3 |
Hemorrhage | |
Hyperplasia, Histiocytic | |
Inflammation | |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 1 2 2 2 2 3 1 3 |
Hyperplasia, Histiocytic | 4 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + A + + + M M + + + + + +|
Necrosis | 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periosteum, Hemorrhage | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Infiltration Cellular, Mixed Cell | |
Mineralization | 1 1 1 1|
Thrombosis | 2 |
Ventricle, Cyst Epithelial Inclusion | |
__________________________________________________________________________|
Spinal Cord | + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 2| 2| 2| 0| 3| 2| 3| 2| 4| 3| 2| 4| 4| 2| 3| 3| 3| 3| 3| 2| 3| 4| 2| 3| 3|
DAY ON TEST | 8| 7| 2| 1| 9| 8| 0| 4| 2| 5| 5| 2| 1| 9| 2| 7| 6| 1| 5| 5| 1| 1| 3| 7| 1|
| 5| 2| 1| 1| 2| 0| 0| 6| 5| 6| 3| 5| 8| 6| 9| 3| 7| 6| 7| 7| 6| 8| 0| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
625 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5|
| 1| 2| 3| 4| 2| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + A + I A + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hemorrhage | 2 1 1 1 2 1 |
Infiltration Cellular, Mixed Cell | |
Thrombosis | 3 |
Alveolar Epithelium, Hyperplasia | 1 4 2 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Peribronchiolar, Inflammation, | |
Pyogranulomatous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Atrophy | 4 3 |
Olfactory Epithelium, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + A + A A + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + M + + + + M + + + + + + + + + + M M + + M + +|
Hyperplasia | 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Metaplasia, Osseous | |
Thrombosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Histiocytic | 2 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 3| 4| 2| 2| 3| | |
DAY ON TEST | 8| 1| 3| 8| 6| | |
| 5| 8| 2| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| | A |
625 PPM | 5| 6| 6| 6| 6| | L |
| 5| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + + | 79 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + | 55 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 77 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 73 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + | 73 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + | 62 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + | 66 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 60 |
Hemorrhage | | 2 1.5|
__________________________________________________________________________|____________|
Liver | + + + + + | 80 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 1 |
Eosinophilic Focus | | 2 |
Hematopoietic Cell Proliferation | 2 | 10 1.4|
Inflammation, Chronic | | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis | 2 | 17 2.1|
Thrombosis | | 1 3.0|
Biliary Tract, Cyst | | 2 |
Centrilobular, Degeneration, Fatty | | 3 2.7|
Centrilobular, Necrosis | | 7 2.1|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Fat, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 78 |
Acinus, Atrophy | 1 | 1 1.0|
Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 79 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 79 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 79 |
Ulcer | 1 | 11 1.4|
Epithelium, Hyperplasia | 2 2 3 | 47 2.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 76 |
Hemorrhage | 1 | 2 1.5|
Pigmentation, Hemosiderin | | 4 1.8|
Ulcer | | 2 1.5|
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 3| 4| 2| 2| 3| | |
DAY ON TEST | 8| 1| 3| 8| 6| | |
| 5| 8| 2| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| | A |
625 PPM | 5| 6| 6| 6| 6| | L |
| 5| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + | 80 |
Cardiomyopathy | | 2 2.0|
Mineralization | | 11 1.3|
Necrosis | | 3 1.7|
Atrium, Thrombosis | | 2 3.0|
Endothelium, Hyperplasia | 2 3 | 8 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 78 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 78 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 76 |
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 78 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 69 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 71 |
Pars Distalis, Cyst | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 78 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + | 79 |
Angiectasis | 4 | 17 2.1|
Atrophy | 3 4 3 3 | 69 2.8|
Cyst | | 13 |
Germinal Epithelium, Hyperplasia | 1 1 | 18 1.6|
Granulosa Cell, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Uterus | + + + + + | 78 |
Atrophy | 2 2 | 41 1.7|
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 3| 4| 2| 2| 3| | |
DAY ON TEST | 8| 1| 3| 8| 6| | |
| 5| 8| 2| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| | A |
625 PPM | 5| 6| 6| 6| 6| | L |
| 5| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Histiocytic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 79 |
Atrophy | | 11 3.7|
Hyperplasia | 3 3 | 18 2.6|
Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 79 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + | 54 |
Congestion | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + | 58 |
Hyperplasia, Histiocytic | | 3 2.3|
Hyperplasia, Plasma Cell | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 67 |
Congestion | | 4 2.5|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 71 |
Congestion | | 1 3.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Histiocytic | | 1 2.0|
Inflammation | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 78 |
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 | 26 2.3|
Hyperplasia, Histiocytic | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + | 71 |
Necrosis | 2 2 | 23 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + | 77 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + | 79 |
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 3| 4| 2| 2| 3| | |
DAY ON TEST | 8| 1| 3| 8| 6| | |
| 5| 8| 2| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| | A |
625 PPM | 5| 6| 6| 6| 6| | L |
| 5| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 80 |
Periosteum, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Hemorrhage | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 80 |
Hemorrhage | | 5 1.6|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Mineralization | | 11 1.0|
Thrombosis | | 1 2.0|
Ventricle, Cyst Epithelial Inclusion | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 9 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 72 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + | 78 |
Hemorrhage | | 12 1.5|
Infiltration Cellular, Mixed Cell | 2 2 | 3 1.7|
Thrombosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 11 2.2|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 3 2.7|
Peribronchiolar, Inflammation, | | |
Pyogranulomatous | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 79 |
Inflammation, Suppurative | | 1 1.0|
Olfactory Epithelium, Atrophy | | 7 3.3|
Olfactory Epithelium, Inflammation, | | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 73 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + + M + + | 66 |
Hyperplasia | 2 | 7 1.9|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 3| 4| 2| 2| 3| | |
DAY ON TEST | 8| 1| 3| 8| 6| | |
| 5| 8| 2| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| | A |
625 PPM | 5| 6| 6| 6| 6| | L |
| 5| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 80 |
Glomerulosclerosis | | 1 3.0|
Metaplasia, Osseous | | 1 1.0|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + | 75 |
Hemorrhage | 2 1 | 3 1.3|
Hyperplasia, Histiocytic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 6| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 6| 6| 6| 6| 6| 7| 6| 1| 2| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 7| 7| 7| 8|
| 1| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 3| 5| 2| 4| 5| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Ulcer | |
Peyer's Patch, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Inflammation, | |
Granulomatous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Infarct | 4 |
Inflammation, Chronic | |
Mixed Cell Focus | X |
Necrosis | |
Centrilobular, Degeneration, Fatty | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Angiectasis | 4 |
Fat, Inflammation, Granulomatous | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Mast Cell | 1 |
Ulcer | 2 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 1 1 |
Ulcer | 1 2 |
__________________________________________________________________________|
Tooth | + + + + |
Inflammation | 1 2 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 6| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 6| 6| 6| 6| 6| 7| 6| 1| 2| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 7| 7| 7| 8|
| 1| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 3| 5| 2| 4| 5| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 1 2 |
Hyperplasia | 2 2 |
Hypertrophy | 2 1 1 1 2 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M + + I + + + + M + + + M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Muscularis, Hyperplasia | |
__________________________________________________________________________|
Penis | +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + +|
Degeneration, Cystic | 2 |
Hyperplasia | 3 |
Inflammation, Suppurative | 3 3 3 2|
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + M + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 3 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 6| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 6| 6| 6| 6| 6| 7| 6| 1| 2| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 7| 7| 7| 8|
| 1| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 3| 5| 2| 4| 5| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Mast Cell | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + + + M M + M + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + M M M + + + M + + + + + M + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + M M + M + M + M + M M M + + + + M M|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | 2 3 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 1 2 2 2 3 2 |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M M + M M M M M M M + M M I M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Suppurative | 4 |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | |
Subcutaneous Tissue, Inflammation, | |
Pyogranulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic, Diffuse | 4 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 6| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 6| 6| 6| 6| 6| 7| 6| 1| 2| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 7| 7| 7| 8|
| 1| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 3| 5| 2| 4| 5| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 4 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 2 1 1 1 1 1 1 1 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
Lens, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Zymbal's Gland | + + |
Cyst | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Mast Cell | 1 |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | |
Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Papilla, Necrosis | |
Renal Tubule, Hyperplasia | 4 |
__________________________________________________________________________|
Urethra | +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3|
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 5| 5| 3| 7| 7| 5| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 0| 3| 9| 3| 7| 4| 7| 3| 3| 9| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 9| 6| 5| 6| 2| 3| 9| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 3| 4| 1| 2| 5| 1| 4| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + A + + + + + + + M M + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + A + + + + + + + + + + + + + + + + +| 47 |
Ulcer | 2 | 1 2.0|
Peyer's Patch, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + A + + + + + + + + + + + + + + + + +| 48 |
Peyer's Patch, Inflammation, | | |
Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 3 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X| 3 |
Infarct | | 1 4.0|
Inflammation, Chronic | 2 | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis | 3 2 3 1 | 4 2.3|
Centrilobular, Degeneration, Fatty | 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Fat, Angiectasis | | 1 4.0|
Fat, Inflammation, Granulomatous | 4 | 1 4.0|
Fat, Necrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Mast Cell | | 1 1.0|
Ulcer | 2 2 | 3 2.0|
Epithelium, Hyperplasia | 2 2 1 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation, Hemosiderin | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 5| 5| 3| 7| 7| 5| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 0| 3| 9| 3| 7| 4| 7| 3| 3| 9| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 9| 6| 5| 6| 2| 3| 9| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 3| 4| 1| 2| 5| 1| 4| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 1 | 3 1.3|
__________________________________________________________________________|____________|
Tooth | + + + + + | 9 |
Inflammation | 3 2 2 2 2 | 9 1.9|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 3 | 4 1.8|
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | 1 1 1 | 6 1.2|
Hyperplasia | 2 2 2 2 | 6 2.0|
Hypertrophy | 2 1 1 1 1 1 2 1| 16 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + + + + + + + + + + + + + + + M M M| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Inflammation | 1 1 | 2 1.0|
Follicular Cell, Hyperplasia | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
Muscularis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Penis | + + + | 4 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + M + + | 7 |
Degeneration, Cystic | | 1 2.0|
Hyperplasia | 2 | 2 2.5|
Inflammation, Suppurative | 2 1 | 6 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + M + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 5| 5| 3| 7| 7| 5| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 0| 3| 9| 3| 7| 4| 7| 3| 3| 9| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 9| 6| 5| 6| 2| 3| 9| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 3| 4| 1| 2| 5| 1| 4| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 1 1.0|
Degeneration | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 3 2 1 2 1 | 13 1.8|
Infiltration Cellular, Mast Cell | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + M + + + M + + + M + + + + + + M + + +| 39 |
Hyperplasia | 2 1 2 | 5 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + M + + + + + M M M + M + M + M M + + M M + +| 28 |
Hyperplasia | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 4 | 2 3.0|
Congestion | 2 3 | 4 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 2 2 3 2 1 1 2| 11 1.9|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 1 2 2 1 2 | 10 1.9|
__________________________________________________________________________|____________|
Thymus | + + I + + + + + + + M + + + + + + + + + + + + + +| 47 |
Necrosis | 1 2 3 2 3 1 | 13 1.9|
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M + M M M M M M M M| 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prepuce, Inflammation, Suppurative | 3 | 2 3.5|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | 4 | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Pyogranulomatous | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 5| 5| 3| 7| 7| 5| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 0| 3| 9| 3| 7| 4| 7| 3| 3| 9| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 9| 6| 5| 6| 2| 3| 9| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 3| 4| 1| 2| 5| 1| 4| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | | 1 |
Mineralization | 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic, Diffuse | 3 | 2 3.5|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 3 2 3 | 10 2.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 | 19 1.1|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 | 24 1.0|
Metaplasia, Squamous | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Inflammation, Chronic | 2 | 1 2.0|
Lens, Degeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 5| 5| 3| 7| 7| 5| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 0| 3| 9| 3| 7| 4| 7| 3| 3| 9| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| |
| 4| 9| 6| 5| 6| 2| 3| 9| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 3| 4| 1| 2| 5| 1| 4| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X | 4 |
Hyperplasia, Mast Cell | | 1 1.0|
Inflammation, Suppurative | | 1 2.0|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 2 2 1 2 1 1 3 2 1 1 1 1 1 1 1| 31 1.2|
Papilla, Necrosis | 3 | 1 3.0|
Renal Tubule, Hyperplasia | 2 | 2 3.0|
__________________________________________________________________________|____________|
Urethra | + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 3 4 1 2 3 | 9 2.9|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3|
| 2| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 7| 5| 6| 4| 5| 5| 5| 5| 5| 5| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6.25 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5|
| 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 4| 5| 1| 2| 3| 4| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + + A + + M + + + + + + + + +|
Hyperplasia | 1 |
Inflammation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + A + + A + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + A + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 4 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + A + + A + + + + + + + + +|
Peyer's Patch, Hyperplasia | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 |
Basophilic Focus | X |
Clear Cell Focus | |
Degeneration, Fatty | 1 1 1 |
Eosinophilic Focus | X X X X |
Inflammation, Chronic | |
Mixed Cell Focus | |
Necrosis | 2 |
Centrilobular, Degeneration, Fatty | |
__________________________________________________________________________|
Mesentery | |
Fat, Angiectasis | |
Fat, Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +|
Acinus, Angiectasis | |
Acinus, Focal Cellular Change | 1 |
Acinus, Necrosis | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Inflammation, Suppurative | |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Tooth | + + |
Inflammation | 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3|
| 2| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 7| 5| 6| 4| 5| 5| 5| 5| 5| 5| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6.25 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5|
| 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 4| 5| 1| 2| 3| 4| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Suppurative | |
Necrosis | |
Endothelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Focal Cellular Change | 2 1 1 1 |
Hyperplasia | 1 3 2 1 |
Hypertrophy | 1 1 1 1 2 1 2 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia | 2 1 1|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M M + M + + + M M + + + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + I + + + + + + + + I + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
Pars Intermedia, Hyperplasia | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Follicular Cell, Hyperplasia | 3 1 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + A + + + + + A + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3|
| 2| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 7| 5| 6| 4| 5| 5| 5| 5| 5| 5| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6.25 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5|
| 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 4| 5| 1| 2| 3| 4| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Mineralization | 1 |
Spermatocele | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | I + + + + + + + + M + + + + M + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + M + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + M M + + M M M M + + + + + + + + + M + M|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + A + + + + M + + + + + + +|
Angiectasis | 1 2 1 1 |
Congestion | 3 3 2 |
Hematopoietic Cell Proliferation | 2 1 2 |
Hemorrhage | |
Hyperplasia | 3 1 1 1 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 1 1 2 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + I + + + + A + + + + + I + + + + + +|
Hyperplasia, Lymphoid | 1 |
Necrosis | 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M I M + M M M M M M M M M M M M M M M I M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Foot, Developmental Malformation | X |
Prepuce, Inflammation, Suppurative | 4 |
Subcutaneous Tissue, Angiectasis | |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3|
| 2| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 7| 5| 6| 4| 5| 5| 5| 5| 5| 5| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6.25 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5|
| 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 4| 5| 1| 2| 3| 4| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + A + + A + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 1 2 2 |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 3 2 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | 1 |
Infarct | |
Inflammation, Suppurative | |
Metaplasia, Osseous | 1 |
Nephropathy | 4 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1|
Papilla, Necrosis | |
__________________________________________________________________________|
Urethra | |
Inflammation, Suppurative | |
Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + A + + + + + + + + +|
Dilatation | 2 |
Inflammation | |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 0| 3| 3| 3| |
| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 7| 5| 5| 1| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
6.25 PPM | 5| 5| 6| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| L |
| 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 3| 4| 5| 1| 4| 5| 2| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 3 | 2 2.0|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +| 46 |
Angiectasis | | 1 2.0|
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Peyer's Patch, Hyperplasia | | 2 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| 46 |
Peyer's Patch, Hyperplasia | 4 | 2 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 4 1.5|
Basophilic Focus | X X | 3 |
Clear Cell Focus | X | 1 |
Degeneration, Fatty | | 3 1.0|
Eosinophilic Focus | X X | 6 |
Inflammation, Chronic | 1 | 1 1.0|
Mixed Cell Focus | X | 1 |
Necrosis | 1 1 1 1 | 5 1.2|
Centrilobular, Degeneration, Fatty | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 5 |
Fat, Angiectasis | 1 2 | 2 1.5|
Fat, Inflammation, Chronic | 3 | 1 3.0|
Fat, Necrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Angiectasis | 2 | 1 2.0|
Acinus, Focal Cellular Change | | 1 1.0|
Acinus, Necrosis | 1 | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 0| 3| 3| 3| |
| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 7| 5| 5| 1| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
6.25 PPM | 5| 5| 6| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| L |
| 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 3| 4| 5| 1| 4| 5| 2| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 1 | 1 1.0|
Pigmentation, Hemosiderin | 1 | 2 1.5|
__________________________________________________________________________|____________|
Tooth | + + | 4 |
Inflammation | 2 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Cardiomyopathy | 1 | 1 1.0|
Inflammation, Suppurative | 2 | 1 2.0|
Necrosis | 2 | 1 2.0|
Endothelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X| 2 |
Focal Cellular Change | 2 1 1 1 2 1 1 1 2 | 13 1.3|
Hyperplasia | 2 1 4 2 | 8 2.0|
Hypertrophy | 1 2 1 1 1 1 2 | 16 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 1 1 | 8 1.1|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + I + + M + + + + + M + + M + + + + + +| 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + I + + +| 47 |
Pars Distalis, Cyst | X| 1 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
Pars Intermedia, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 3 |
Follicular Cell, Hyperplasia | 2 2 2 1 | 11 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 0| 3| 3| 3| |
| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 7| 5| 5| 1| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
6.25 PPM | 5| 5| 6| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| L |
| 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 3| 4| 5| 1| 4| 5| 2| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 3 1| 2 2.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
Inflammation, Suppurative | 2 | 2 1.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
Inflammation, Suppurative | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 | 3 1.7|
Mineralization | | 1 1.0|
Spermatocele | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 | 5 1.4|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M M M + + + + + + + M + M + + + + + + + + +| 42 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 1 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + I M + + + M + + + + M M + + M + M + + + + + + +| 39 |
Hyperplasia | 1 1 1 2 | 5 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + M M M + M M + + M M M M + + + + + + M M + M| 27 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Angiectasis | 2 1 1 1 1 | 9 1.2|
Congestion | 3 3 4 3 | 7 3.0|
Hematopoietic Cell Proliferation | 3 2 2 1 | 7 1.9|
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 1 2 1 2 2 1 2 2 1 2 4 | 17 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 1 1 2 2 1 1 4 2| 15 1.6|
Hyperplasia, Lymphoid | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Thymus | + + M + + + + M + + + + + + + M + M + + + + + + +| 43 |
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 0| 3| 3| 3| |
| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 7| 5| 5| 1| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
6.25 PPM | 5| 5| 6| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| L |
| 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 3| 4| 5| 1| 4| 5| 2| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Necrosis | 2 3 | 7 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M M M + M M M M M M M M M M M M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
Foot, Developmental Malformation | | 1 |
Prepuce, Inflammation, Suppurative | 4 4 | 3 4.0|
Subcutaneous Tissue, Angiectasis | 4| 1 4.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 27 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 6 1.8|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 2 1 3 2 2 | 9 2.1|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 3 | 4 2.3|
Perivascular, Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 1 1 | 15 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 24 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hyperplasia | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 0| 3| 3| 3| |
| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 7| 5| 5| 1| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
6.25 PPM | 5| 5| 6| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| L |
| 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 3| 4| 5| 1| 4| 5| 2| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X X | 8 |
Hydronephrosis | 2 | 2 1.5|
Infarct | 1 | 1 1.0|
Inflammation, Suppurative | 2 | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.1|
Papilla, Necrosis | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Urethra | + + | 2 |
Inflammation, Suppurative | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Dilatation | 3 3 | 3 2.7|
Inflammation | 2 | 1 2.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 5| 7| 5| 6| 7| 6| 4| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 9| 3| 3| 3| 4| 3| 1| 0| 3| 8| 5| 8| 3| 1| 3| 3| 1| 3| 3| 3| 5| 8| 8| 8| 3|
| 7| 4| 4| 2| 0| 4| 7| 4| 4| 0| 6| 5| 4| 8| 4| 4| 0| 4| 4| 4| 8| 6| 9| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 1| 3| 4| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | A + + + + + A A + + + A + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + A + + + + + + + + + + + I + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + A + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + I + + A + + + A + + + + + + + + + + + + +|
Inflammation, Chronic | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + A A + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Degeneration, Fatty | 1 |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | |
Infarct | 3 4 |
Inflammation, Focal, Granulomatous | 2 |
Necrosis | 1 1 2 |
Biliary Tract, Cyst | X |
Centrilobular, Degeneration, Fatty | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Angiectasis | 2 1 2 |
Fat, Hemorrhage | 1 |
Fat, Inflammation, Chronic | 1 2 1 |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 |
Acinus, Focal Cellular Change | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 2 |
Ulcer | 2 |
Epithelium, Hyperplasia | 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 5| 7| 5| 6| 7| 6| 4| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 9| 3| 3| 3| 4| 3| 1| 0| 3| 8| 5| 8| 3| 1| 3| 3| 1| 3| 3| 3| 5| 8| 8| 8| 3|
| 7| 4| 4| 2| 0| 4| 7| 4| 4| 0| 6| 5| 4| 8| 4| 4| 0| 4| 4| 4| 8| 6| 9| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 1| 3| 4| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 1 |
Ulcer | |
__________________________________________________________________________|
Tooth | + + + |
Inflammation | 2 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Focal Cellular Change | 1 1 1 |
Hyperplasia | 2 |
Hypertrophy | 1 1 2 1 1 1 1 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M M + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Penis | + M + M |
Hyperplasia | 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Preputial Gland | + |
Degeneration, Cystic | |
Inflammation, Suppurative | |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Prostate | + M + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 5| 7| 5| 6| 7| 6| 4| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 9| 3| 3| 3| 4| 3| 1| 0| 3| 8| 5| 8| 3| 1| 3| 3| 1| 3| 3| 3| 5| 8| 8| 8| 3|
| 7| 4| 4| 2| 0| 4| 7| 4| 4| 0| 6| 5| 4| 8| 4| 4| 0| 4| 4| 4| 8| 6| 9| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 1| 3| 4| 1| 2| 3|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 1 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Mineralization | 1 |
Spermatocele | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + M M + + + + + + + + + + + + + + M + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + I M + + + + + M + M M M + M M M + + + + M|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + I + + + + +|
Angiectasis | 2 3 2 |
Congestion | 3 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Hyperplasia | 2 2 2 2 2 2|
Inflammation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 1 2 |
Hyperplasia, Histiocytic | 4 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + I + + + + M + + + + M + + + + + + + + + M +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mixed Cell | 2 |
Necrosis | 3 2 2 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M I M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Suppurative | 4 3 4 |
Subcutaneous Tissue, Angiectasis | 2 4 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 5| 7| 5| 6| 7| 6| 4| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 9| 3| 3| 3| 4| 3| 1| 0| 3| 8| 5| 8| 3| 1| 3| 3| 1| 3| 3| 3| 5| 8| 8| 8| 3|
| 7| 4| 4| 2| 0| 4| 7| 4| 4| 0| 6| 5| 4| 8| 4| 4| 0| 4| 4| 4| 8| 6| 9| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 1| 3| 4| 1| 2| 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Inflammation, | |
Pyogranulomatous | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | X |
Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 2 |
Inflammation, Chronic, Diffuse | |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 2 1 1 1 1 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
Olfactory Epithelium, Atrophy | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | 3 |
Infarct | |
Inflammation, Suppurative | 1 2 |
Nephropathy | 1 1 1 1 1 1 3 1 1 1 1|
Renal Tubule, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 5| 7| 5| 6| 7| 6| 4| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 9| 3| 3| 3| 4| 3| 1| 0| 3| 8| 5| 8| 3| 1| 3| 3| 1| 3| 3| 3| 5| 8| 8| 8| 3|
| 7| 4| 4| 2| 0| 4| 7| 4| 4| 0| 6| 5| 4| 8| 4| 4| 0| 4| 4| 4| 8| 6| 9| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
20 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 1| 3| 4| 1| 2| 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urethra | + |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2 3 |
Inflammation | 2 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 5| 7| 5| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 5| 5| 7| 6| 7| |
DAY ON TEST | 5| 3| 8| 3| 7| 3| 8| 6| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 9| 3| |
| 1| 4| 9| 4| 3| 4| 6| 8| 4| 2| 4| 4| 7| 4| 4| 9| 4| 4| 4| 1| 2| 6| 4| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
20 PPM | 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| L |
| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 5| 1| 2| 4| 5| 1| 2| 4| 1| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + A + + + + + A + + A + + I + + A + + +| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + A + + A + + + + + A + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + + A + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + A + + + + + A + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + A + + A + + + + + A + + +| 44 |
Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + A + + A + + + + + A + + +| 42 |
Inflammation, Chronic | 1 | 1 1.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + A + + A + + + + + A + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + A + + A + + + + + A + + +| 43 |
Cyst | X | 1 |
Inflammation, Chronic | 1 | 1 1.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Clear Cell Focus | X | 1 |
Degeneration, Fatty | 1 1 | 3 1.0|
Eosinophilic Focus | X | 4 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Infarct | 4 4 4 | 5 3.8|
Inflammation, Focal, Granulomatous | | 1 2.0|
Necrosis | 2 1 2 2 1 | 8 1.5|
Biliary Tract, Cyst | | 1 |
Centrilobular, Degeneration, Fatty | 1 | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + | 9 |
Fat, Angiectasis | 2 | 4 1.8|
Fat, Hemorrhage | | 1 1.0|
Fat, Inflammation, Chronic | 2 2 | 5 1.6|
Fat, Necrosis | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Acinus, Atrophy | | 2 1.0|
Acinus, Focal Cellular Change | 1 1 1| 5 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 5| 7| 5| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 5| 5| 7| 6| 7| |
DAY ON TEST | 5| 3| 8| 3| 7| 3| 8| 6| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 9| 3| |
| 1| 4| 9| 4| 3| 4| 6| 8| 4| 2| 4| 4| 7| 4| 4| 9| 4| 4| 4| 1| 2| 6| 4| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
20 PPM | 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| L |
| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 5| 1| 2| 4| 5| 1| 2| 4| 1| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 1 | 2 1.5|
Epithelium, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 2 1.5|
Mineralization | 2 | 1 2.0|
Pigmentation, Hemosiderin | 2 2 | 3 1.7|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + | 6 |
Inflammation | 3 1 2 | 6 2.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 6 1.3|
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Focal Cellular Change | 1 1 1 2 1| 8 1.1|
Hyperplasia | | 1 2.0|
Hypertrophy | 1 1 1 1 1 | 14 1.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + I + + + + + + + + + + + + + + + + M +| 47 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Hyperplasia | 2 1 2 | 4 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + I + + + M + + + + M + + + + M + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + I + + + + + + + + + + + +| 47 |
Pars Distalis, Cyst | X X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X| 1 |
Follicular Cell, Hyperplasia | 1 2 | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypospermia | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 5| 7| 5| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 5| 5| 7| 6| 7| |
DAY ON TEST | 5| 3| 8| 3| 7| 3| 8| 6| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 9| 3| |
| 1| 4| 9| 4| 3| 4| 6| 8| 4| 2| 4| 4| 7| 4| 4| 9| 4| 4| 4| 1| 2| 6| 4| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
20 PPM | 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| L |
| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 5| 1| 2| 4| 5| 1| 2| 4| 1| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 3 | 3 1.7|
__________________________________________________________________________|____________|
Penis | + M M + | 4 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Preputial Gland | + + + | 4 |
Degeneration, Cystic | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Duct, Dilatation | 3 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 | 2 1.5|
Inflammation, Suppurative | 3 1 2 | 5 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + A + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 1 2 | 4 1.8|
Mineralization | 1 | 2 1.0|
Spermatocele | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + + + M + + + + + + M M M + + M| 42 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + + + + + + M + + + + + M M + + + M + M| 38 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + M + + M M + M + M M + + + + + + + + + +| 33 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| 47 |
Angiectasis | 1 1| 5 1.8|
Congestion | 4 3 4 | 4 3.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 2 2 2 1 2 1| 12 1.8|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 5| 7| 5| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 5| 5| 7| 6| 7| |
DAY ON TEST | 5| 3| 8| 3| 7| 3| 8| 6| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 9| 3| |
| 1| 4| 9| 4| 3| 4| 6| 8| 4| 2| 4| 4| 7| 4| 4| 9| 4| 4| 4| 1| 2| 6| 4| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
20 PPM | 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| L |
| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 5| 1| 2| 4| 5| 1| 2| 4| 1| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 1 2 3 1 2 | 9 1.9|
Hyperplasia, Histiocytic | | 1 4.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | M + + + M + + + + + + + + + + + + + M M + + + + +| 42 |
Hyperplasia, Lymphoid | 1| 1 1.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Necrosis | 2 2 2 2 1 1 2 2 1 1 | 18 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M I M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prepuce, Inflammation, Suppurative | 3 3 3 3 | 7 3.3|
Subcutaneous Tissue, Angiectasis | | 2 3.0|
Subcutaneous Tissue, Edema | 2 | 1 2.0|
Subcutaneous Tissue, Hemorrhage | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Pyogranulomatous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fracture | | 1 |
Osteopetrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | M | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 1 1| 16 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 | 6 1.3|
Inflammation, Chronic, Diffuse | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 2 2 | 6 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 2 2 | 7 2.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 1 1 1 | 21 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 7| 5| 7| 5| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 5| 5| 7| 6| 7| |
DAY ON TEST | 5| 3| 8| 3| 7| 3| 8| 6| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 9| 3| |
| 1| 4| 9| 4| 3| 4| 6| 8| 4| 2| 4| 4| 7| 4| 4| 9| 4| 4| 4| 1| 2| 6| 4| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
20 PPM | 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| L |
| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 5| 1| 2| 4| 5| 1| 2| 4| 1| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 1.0|
Olfactory Epithelium, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 1 1| 19 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 3 | 4 2.0|
Inflammation, Suppurative | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Hydronephrosis | | 1 3.0|
Infarct | 2 | 1 2.0|
Inflammation, Suppurative | 2 1 | 4 1.5|
Nephropathy | 2 1 4 1 1 1 1 2 1 1 1| 22 1.3|
Renal Tubule, Mineralization | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 3 3 3 3 | 8 3.0|
Inflammation | 3 2 | 3 2.3|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 4| 7| 5| 7| 6| 7| 5| 6| 5| 7| 6| 7| 7| 3| 7| 4| 5| 7| 2| 5|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 7| 3| 9| 3| 4| 0| 2| 3| 9| 3| 1| 5| 3| 6| 4| 3| 0| 9|
| 3| 3| 8| 3| 5| 1| 3| 4| 3| 6| 3| 6| 7| 5| 3| 5| 3| 3| 2| 3| 4| 6| 3| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
62.5 PPM | 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1|
| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 2| 5| 1| 2| 3| 4| 5| 1| 2| 5| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + M + + + + + + + + + + + + A +|
__________________________________________________________________________|
Gallbladder | + + A + A M + + + + + M A + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + I + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hemorrhage | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + A +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + A +|
Peyer's Patch, Hyperplasia | 3 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + A +|
Angiectasis | 1 4 |
Basophilic Focus | |
Developmental Malformation | X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 2 |
Infarct | 4 4|
Mixed Cell Focus | X X |
Necrosis | 2 2 1 1 2 1 3 1 |
Centrilobular, Necrosis | 3 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Angiectasis | 2 2 2 |
Fat, Hemorrhage | 2 2 |
Fat, Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +|
Acinus, Focal Cellular Change | 1 1 1|
Acinus, Inflammation, Chronic | |
__________________________________________________________________________|
Pharynx | + |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
Ulcer | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +|
Pigmentation, Hemosiderin | 2 2 1 |
Ulcer | 2 2 1 |
__________________________________________________________________________|
Tooth | + + + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 4| 7| 5| 7| 6| 7| 5| 6| 5| 7| 6| 7| 7| 3| 7| 4| 5| 7| 2| 5|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 7| 3| 9| 3| 4| 0| 2| 3| 9| 3| 1| 5| 3| 6| 4| 3| 0| 9|
| 3| 3| 8| 3| 5| 1| 3| 4| 3| 6| 3| 6| 7| 5| 3| 5| 3| 3| 2| 3| 4| 6| 3| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
62.5 PPM | 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1|
| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 2| 5| 1| 2| 3| 4| 5| 1| 2| 5| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation | 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + A +|
Cardiomyopathy | 1 |
Mineralization | 1 |
Endothelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + M +|
Focal Cellular Change | 1 2 1 1 2 |
Hyperplasia | 1 |
Hypertrophy | 1 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + I + + + + + + + + M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | 2 1|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + M M + + + + + + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
Cyst | X |
C-Cell, Hyperplasia | 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + A +|
Degeneration | 2 1 |
Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Penis | + + +|
Inflammation, Suppurative | 2|
__________________________________________________________________________|
Preputial Gland | + + + +|
Degeneration, Cystic | 4 2 |
Inflammation, Suppurative | 3 |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + M + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | |
Inflammation, Suppurative | 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + A + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 4| 7| 5| 7| 6| 7| 5| 6| 5| 7| 6| 7| 7| 3| 7| 4| 5| 7| 2| 5|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 7| 3| 9| 3| 4| 0| 2| 3| 9| 3| 1| 5| 3| 6| 4| 3| 0| 9|
| 3| 3| 8| 3| 5| 1| 3| 4| 3| 6| 3| 6| 7| 5| 3| 5| 3| 3| 2| 3| 4| 6| 3| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
62.5 PPM | 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1|
| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 2| 5| 1| 2| 3| 4| 5| 1| 2| 5| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + A +|
Atrophy | 1 |
Degeneration | 1 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +|
Angiectasis | 2 |
Hyperplasia | 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | |
Iliac, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + M + + M + M I + + + + + + + + M M + A +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + M + + + + + + + + + M + M M M + M + M A M|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + M M M + M + + + + + M + + M M M + + M A M|
Congestion | 3 |
Hematopoietic Cell Proliferation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + A +|
Angiectasis | 2 1 1 |
Congestion | 2 3 2 3 1 |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia | 1 3 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hematopoietic Cell Proliferation | 4 3 1 1 2 1 3 2 2 |
Hyperplasia, Lymphoid | |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | M + + + M M + + + + + + + + + + + + + + + + + A M|
Hyperplasia, Lymphoid | 3 |
Necrosis | 2 2 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + A +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic | 3 |
Hair Follicle, Atrophy | |
Prepuce, Inflammation, Suppurative | 2 4|
Subcutaneous Tissue, Angiectasis | 1 |
Subcutaneous Tissue, Edema | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 4| 7| 5| 7| 6| 7| 5| 6| 5| 7| 6| 7| 7| 3| 7| 4| 5| 7| 2| 5|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 7| 3| 9| 3| 4| 0| 2| 3| 9| 3| 1| 5| 3| 6| 4| 3| 0| 9|
| 3| 3| 8| 3| 5| 1| 3| 4| 3| 6| 3| 6| 7| 5| 3| 5| 3| 3| 2| 3| 4| 6| 3| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
62.5 PPM | 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1|
| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 2| 5| 1| 2| 3| 4| 5| 1| 2| 5| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hemorrhage | 1 |
Mineralization | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Suppurative | 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 3 |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 2 1 2 1 1 2 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Suppurative | 1 1 1 2 1 1 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 |
Olfactory Epithelium, Atrophy | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Lens, Degeneration | 1 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 1 1 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +|
Cyst | |
Hydronephrosis | 1 |
Inflammation, Suppurative | 1|
Nephropathy | 1 1 1 1 1 1 1 1 1 |
Capsule, Inflammation, Chronic | |
Renal Tubule, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 4| 7| 5| 7| 6| 7| 5| 6| 5| 7| 6| 7| 7| 3| 7| 4| 5| 7| 2| 5|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 7| 3| 9| 3| 4| 0| 2| 3| 9| 3| 1| 5| 3| 6| 4| 3| 0| 9|
| 3| 3| 8| 3| 5| 1| 3| 4| 3| 6| 3| 6| 7| 5| 3| 5| 3| 3| 2| 3| 4| 6| 3| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
62.5 PPM | 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1|
| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 2| 5| 1| 2| 3| 4| 5| 1| 2| 5| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +|
Dilatation | 3 2 3|
Inflammation | 1|
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 0| 4| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 9| 5| 4| 3| 3| 3| 6| 4| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 0| 3| 3| 3| 0| |
| 3| 6| 6| 8| 9| 7| 3| 3| 2| 0| 3| 4| 3| 3| 3| 0| 3| 2| 4| 3| 7| 3| 3| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
62.5 PPM | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 4| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 2| 3| 4| 5| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + M + + + + + I + + + +| 44 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A A M I + + + + + + + + + A M A + + + +| 36 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + A + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M A + + + + + + + + + + + + + A + + + +| 44 |
Peyer's Patch, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + I + + + + + +| 46 |
Peyer's Patch, Hyperplasia | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + A + A + + + +| 44 |
Peyer's Patch, Hyperplasia | 4 | 3 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 | 3 2.3|
Basophilic Focus | X X X X X| 5 |
Developmental Malformation | | 1 |
Eosinophilic Focus | X X| 3 |
Hematopoietic Cell Proliferation | 4 | 3 2.7|
Infarct | 4 | 3 4.0|
Mixed Cell Focus | X X | 4 |
Necrosis | 2 1 3 2 1 | 13 1.7|
Centrilobular, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + +| 14 |
Fat, Angiectasis | 2 1 2 | 6 1.8|
Fat, Hemorrhage | 1 | 3 1.7|
Fat, Inflammation, Chronic | 1 2 | 2 1.5|
Fat, Necrosis | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Focal Cellular Change | 1 | 4 1.0|
Acinus, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ulcer | 3 2 2 2 | 4 2.3|
Epithelium, Hyperplasia | 2 2 2 2 2 | 6 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 0| 4| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 9| 5| 4| 3| 3| 3| 6| 4| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 0| 3| 3| 3| 0| |
| 3| 6| 6| 8| 9| 7| 3| 3| 2| 0| 3| 4| 3| 3| 3| 0| 3| 2| 4| 3| 7| 3| 3| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
62.5 PPM | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 4| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 2| 3| 4| 5| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pigmentation, Hemosiderin | 2 1 | 5 1.6|
Ulcer | 2 1 | 5 1.6|
__________________________________________________________________________|____________|
Tooth | | 3 |
Developmental Malformation | | 1 |
Inflammation | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cardiomyopathy | 1 2| 3 1.3|
Mineralization | | 1 1.0|
Endothelium, Hyperplasia | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Focal Cellular Change | 1 1 1 1 1 1 1| 12 1.2|
Hyperplasia | 2 3 | 3 2.0|
Hypertrophy | 1 2 1 1 1 1 1 | 11 1.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + A + + + + + M + + + + + + + + + + + +| 44 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + + + + + + + + + + + + M M + + + +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | X X X | 4 |
C-Cell, Hyperplasia | | 1 2.0|
Follicular Cell, Hyperplasia | 4 4 2 1| 5 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Degeneration | | 2 1.5|
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 0| 4| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 9| 5| 4| 3| 3| 3| 6| 4| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 0| 3| 3| 3| 0| |
| 3| 6| 6| 8| 9| 7| 3| 3| 2| 0| 3| 4| 3| 3| 3| 0| 3| 2| 4| 3| 7| 3| 3| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
62.5 PPM | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 4| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 2| 3| 4| 5| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Penis | + + + + | 7 |
Inflammation, Suppurative | 2 | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + +| 9 |
Degeneration, Cystic | 2 | 3 2.7|
Inflammation, Suppurative | 2| 2 2.5|
Duct, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + I M +| 45 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Suppurative | 2| 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + A + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 1 | 2 1.0|
Degeneration | | 3 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
Hyperplasia | 2 2 2 2 2 2 2 2 2| 17 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 | 1 3.0|
Iliac, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + + + M + M + + + + + + + + M| 37 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + + + + M + + + + M + + + M + + + + +| 33 |
Hyperplasia | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + M + M M + + + + + + + + + + M + + + + + +| 32 |
Congestion | 3 | 2 3.0|
Hematopoietic Cell Proliferation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + + + + + +| 46 |
Angiectasis | 2 1 1 3 2 | 8 1.6|
Congestion | 2 2 2 3 2| 10 2.2|
Hematopoietic Cell Proliferation | 2 2| 4 2.0|
Hyperplasia | 2 2 3 2 | 7 2.1|
Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 1 2 2 4 1 2| 22 2.0|
Hyperplasia, Lymphoid | 3 2 | 2 2.5|
Necrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 0| 4| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 9| 5| 4| 3| 3| 3| 6| 4| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 0| 3| 3| 3| 0| |
| 3| 6| 6| 8| 9| 7| 3| 3| 2| 0| 3| 4| 3| 3| 3| 0| 3| 2| 4| 3| 7| 3| 3| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
62.5 PPM | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 4| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 2| 3| 4| 5| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + A + + I + + + + + M M + + + + + + + +| 40 |
Hyperplasia, Lymphoid | 4 | 2 3.5|
Necrosis | 3 2 2 2 1 1 1 1 2 1 | 17 1.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst Epithelial Inclusion | X | 1 |
Inflammation, Chronic | 2 2 | 3 2.3|
Hair Follicle, Atrophy | 1 | 1 1.0|
Prepuce, Inflammation, Suppurative | 4 4 4 3 4| 7 3.6|
Subcutaneous Tissue, Angiectasis | | 1 1.0|
Subcutaneous Tissue, Edema | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 1.0|
Mineralization | 1 1 1 1 1 1 1| 15 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + A A + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Suppurative | 2 1 | 4 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 1 | 3 2.7|
Inflammation, Chronic, Focal | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 1 4 1 2 2| 13 1.8|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 3 | 5 2.6|
__________________________________________________________________________|____________|
Nose | + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 1| 15 1.1|
Nasolacrimal Duct, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 0| 4| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 9| 5| 4| 3| 3| 3| 6| 4| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 0| 3| 3| 3| 0| |
| 3| 6| 6| 8| 9| 7| 3| 3| 2| 0| 3| 4| 3| 3| 3| 0| 3| 2| 4| 3| 7| 3| 3| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
62.5 PPM | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 4| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 2| 3| 4| 5| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Suppurative | 2 2 2 2 1 1 1 | 9 1.6|
Olfactory Epithelium, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + A A + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 1| 19 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Degeneration | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Hyperplasia | 2 2 | 6 2.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | X X | 2 |
Hydronephrosis | | 1 1.0|
Inflammation, Suppurative | | 1 1.0|
Nephropathy | 1 1 1 2 1 1 2 1 1 1| 19 1.1|
Capsule, Inflammation, Chronic | 2 | 1 2.0|
Renal Tubule, Hyperplasia | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Urethra | + + + + | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Dilatation | 3 2 2 3 2| 8 2.5|
Inflammation | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 6| 3| 5| 5| 5| 4| 6| 6| 1| 2| 5| 6| 5| 6| 6| 7| 6| 5| 6| 6| 5| 5| 4| 5| 2|
DAY ON TEST | 7| 8| 6| 9| 9| 9| 7| 4| 7| 1| 9| 6| 3| 9| 2| 3| 2| 9| 2| 1| 6| 6| 7| 6| 8|
| 4| 2| 8| 6| 6| 5| 3| 9| 1| 7| 6| 0| 7| 7| 9| 3| 4| 8| 0| 0| 8| 9| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
200 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 0|
| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 4| 5| 2| 4| 5| 2| 3| 4| 5| 1| 3| 5| 1| 5| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + A M + A A A + + + + A A + A + + A|
Hyperplasia | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + A A + + + A A A + + + + A|
Angiectasis | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A A + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + A A + + + + A A + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + A M A + + + + A A + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + A A + + + A A A + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A A + + A A + + + A A A + + + + A|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +|
Basophilic Focus | X |
Degeneration, Fatty | 2 |
Developmental Malformation | |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Focal, Granulomatous | 2 |
Mixed Cell Focus | |
Necrosis | 1 2 2 2 2 3 3 |
Biliary Tract, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Angiectasis | 3 2 |
Fat, Hemorrhage | 2 |
Fat, Inflammation, Chronic | 2 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + A|
Acinus, Atrophy | 3 |
Acinus, Focal Cellular Change | 1 |
__________________________________________________________________________|
Pharynx | + |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Ulcer | 2 1 1 |
Epithelium, Hyperplasia | 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + A|
Pigmentation, Hemosiderin | 2 2 2 1 2 2 |
Ulcer | 2 2 2 2 |
__________________________________________________________________________|
Tooth | + |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 6| 3| 5| 5| 5| 4| 6| 6| 1| 2| 5| 6| 5| 6| 6| 7| 6| 5| 6| 6| 5| 5| 4| 5| 2|
DAY ON TEST | 7| 8| 6| 9| 9| 9| 7| 4| 7| 1| 9| 6| 3| 9| 2| 3| 2| 9| 2| 1| 6| 6| 7| 6| 8|
| 4| 2| 8| 6| 6| 5| 3| 9| 1| 7| 6| 0| 7| 7| 9| 3| 4| 8| 0| 0| 8| 9| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
200 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 0|
| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 4| 5| 2| 4| 5| 2| 3| 4| 5| 1| 3| 5| 1| 5| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + A + + + + + +|
Cardiomyopathy | 1 1 |
Mineralization | 1 1 1 |
Endothelium, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Hypertrophy | 1 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + A + + + + A + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + A|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + M + + M + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + A M + + M + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Degeneration, Cystic | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + A + + + + + A|
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + M + + + + + + + + + A + + + + + A|
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + A + + + + + +|
Angiectasis | |
Atrophy | 2 2 1 1 |
Degeneration | 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 6| 3| 5| 5| 5| 4| 6| 6| 1| 2| 5| 6| 5| 6| 6| 7| 6| 5| 6| 6| 5| 5| 4| 5| 2|
DAY ON TEST | 7| 8| 6| 9| 9| 9| 7| 4| 7| 1| 9| 6| 3| 9| 2| 3| 2| 9| 2| 1| 6| 6| 7| 6| 8|
| 4| 2| 8| 6| 6| 5| 3| 9| 1| 7| 6| 0| 7| 7| 9| 3| 4| 8| 0| 0| 8| 9| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
200 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 0|
| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 4| 5| 2| 4| 5| 2| 3| 4| 5| 1| 3| 5| 1| 5| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 2 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + M + M + M + + + + M M + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + M + M + + + + + + + M + + + + + + M|
Hyperplasia | 2 2 3 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + M + + M + + + + + M + + M + + + M + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + I + + + + + + + + A + + + + + +|
Angiectasis | 3 3 4 4 |
Congestion | 3 2 2 |
Hematopoietic Cell Proliferation | 1 2 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + A|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 3 2 2 1 1 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + I + + M + M + + M + + + M + M + + + + + +|
Necrosis | 2 2 2 2 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M M + M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | 3 |
Hair Follicle, Atrophy | 3 |
Prepuce, Inflammation, Suppurative | 3 |
Sebaceous Gland, Hyperplasia | |
Subcutaneous Tissue, Angiectasis | 3 4 |
Subcutaneous Tissue, Inflammation, | |
Pyogranulomatous | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
Cranium, Hemorrhage | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1|
Mineralization | 2 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
_____________________________________________________________________________________________________________________
| 6| 3| 5| 5| 5| 4| 6| 6| 1| 2| 5| 6| 5| 6| 6| 7| 6| 5| 6| 6| 5| 5| 4| 5| 2|
DAY ON TEST | 7| 8| 6| 9| 9| 9| 7| 4| 7| 1| 9| 6| 3| 9| 2| 3| 2| 9| 2| 1| 6| 6| 7| 6| 8|
| 4| 2| 8| 6| 6| 5| 3| 9| 1| 7| 6| 0| 7| 7| 9| 3| 4| 8| 0| 0| 8| 9| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
200 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 0|
| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 4| 5| 2| 4| 5| 2| 3| 4| 5| 1| 3| 5| 1| 5| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + A A + + + + A|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 1 3|
Inflammation, Suppurative | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 3 1 2 1 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 2 3 2 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 |
Inflammation, Pyogranulomatous | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 1 1 1 |
Olfactory Epithelium, Atrophy | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + A A + + + + A|
Inflammation, Suppurative | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Degeneration | 3 |
Cornea, Hyperplasia | 3 |
Cornea, Inflammation, Chronic | 3 3 |
Lens, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + M + + + + + + + + + + + + + + M|
Hyperplasia | 2 3 1 1 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | 2 |
Inflammation, Suppurative | 3 |
Nephropathy | 1 1 1 1 2 1 |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urethra | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +|
Dilatation | 3 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 2| 7| 4| 5| 4| 7| 5| 5| 6| 3| 5| 6| 5| 6| 5| 5| 4| 5| 7| 6| 4| 6| 3| 5| 5| |
DAY ON TEST | 5| 3| 7| 9| 7| 3| 7| 8| 3| 7| 9| 2| 6| 5| 3| 8| 9| 1| 3| 2| 8| 9| 5| 6| 2| |
| 1| 3| 0| 5| 4| 3| 3| 2| 9| 1| 6| 3| 8| 2| 0| 3| 5| 9| 3| 4| 1| 2| 1| 8| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
200 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 6| L |
| 2| 3| 4| 5| 1| 2| 3| 5| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 5| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + A + + + M + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + A A + + A + + A + A + A + + + M + M| 32 |
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + + + + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + A + A| 40 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + A + A| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + + + + + A + A + + + + + A + A| 39 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + A + + + + + A + A + + + + + A + A| 37 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + A + A + A + + + A + A| 37 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + A A + + + + + A + A + A + A + A + A| 33 |
Peyer's Patch, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Basophilic Focus | | 1 |
Degeneration, Fatty | | 1 2.0|
Developmental Malformation | X | 1 |
Eosinophilic Focus | X X X | 4 |
Hematopoietic Cell Proliferation | 1 2 1 | 4 1.5|
Inflammation, Focal, Granulomatous | | 1 2.0|
Mixed Cell Focus | X | 1 |
Necrosis | 3 3 3 2 2 2 3| 14 2.4|
Biliary Tract, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Fat, Angiectasis | 2 | 3 2.3|
Fat, Hemorrhage | | 1 2.0|
Fat, Inflammation, Chronic | 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + A + +| 46 |
Acinus, Atrophy | | 1 3.0|
Acinus, Focal Cellular Change | | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + A + + + + + + + + + + + + + + + + + + + A + +| 48 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ulcer | 1 | 4 1.3|
Epithelium, Hyperplasia | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + A + + + + + A + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05134-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,3-BUTADIENE Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:22:13
__________________________________________________________________________________________________________________________________
| 2| 7| 4| 5| 4| 7| 5| 5| 6| 3| 5| 6| 5| 6| 5| 5| 4| 5| 7| 6| 4| 6| 3| 5| 5| |
DAY ON TEST | 5| 3| 7| 9| 7| 3| 7| 8| 3| 7| 9| 2| 6| 5| 3| 8| 9| 1| 3| 2| 8| 9| 5| 6| 2| |
| 1| 3| 0| 5| 4| 3| 3| 2| 9| 1| 6| 3| 8| 2| 0| 3| 5| 9| 3| 4| 1| 2| 1| 8| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
200 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 6| L |
| 2| 3| 4| 5| 1| 2| 3| 5| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 5| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Pigmentation, Hemosiderin | 2 1 2 | 9 1.8|
Ulcer | 1 2 1 1 | 8 1.6|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cardiomyopathy