TDMS Study 05135-07 Pathology Tables
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08
2 YEAR CHRONIC
Facility: Battelle Northwest
Chemical CAS #: 78-79-5
Lock Date: 03/13/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 5 5 4
Moribund Sacrifice 16 15 18 23
Survivors
Terminal Sacrifice 29 30 28 27
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (49) (47) (46) (50)
Inflammation, Chronic Active 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 2 (4%) 3 (6%) 4 (8%)
Basophilic Focus 36 (72%) 38 (76%) 33 (66%) 33 (66%)
Clear Cell Focus 9 (18%) 11 (22%) 10 (20%) 11 (22%)
Degeneration, Cystic 1 (2%) 1 (2%)
Degeneration, Fatty 1 (2%)
Eosinophilic Focus 2 (4%) 3 (6%) 1 (2%) 4 (8%)
Fatty Change 8 (16%) 6 (12%) 11 (22%) 9 (18%)
Fibrosis 1 (2%)
Hepatodiaphragmatic Nodule 2 (4%) 4 (8%) 5 (10%) 6 (12%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 4 (8%) 10 (20%) 10 (20%) 5 (10%)
Necrosis 1 (2%)
Regeneration 1 (2%) 2 (4%) 3 (6%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 3 (6%) 9 (18%) 9 (18%) 10 (20%)
Centrilobular, Necrosis 5 (10%) 5 (10%) 8 (16%) 3 (6%)
Periportal, Infiltration Cellular, Lymphocyte 1 (2%)
Mesentery (9) (10) (8) (11)
Fat, Necrosis 9 (100%) 10 (100%) 8 (100%) 11 (100%)
Oral Mucosa (1) (1)
Pharyngeal, Hyperplasia, Squamous 1 (100%)
Pancreas (50) (50) (50) (50)
Atrophy 18 (36%) 13 (26%) 11 (22%) 20 (40%)
Basophilic Focus 1 (2%) 3 (6%) 3 (6%)
Hyperplasia 2 (4%)
Metaplasia, Hepatocyte 2 (4%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Diverticulum 1 (2%)
Hyperplasia, Squamous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis 5 (10%) 2 (4%) 7 (14%) 3 (6%)
Stomach, Glandular (50) (49) (50) (50)
Mineralization 1 (2%)
Necrosis 3 (6%) 3 (6%) 4 (8%) 6 (12%)
Tongue (1) (2)
Hyperplasia 1 (50%)
Tooth (1) (1)
Developmental Malformation 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 35 (70%) 33 (66%) 28 (56%) 37 (74%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Atrophy 1 (2%)
Degeneration, Cystic 1 (2%) 1 (2%) 3 (6%)
Ectopic Tissue 1 (2%)
Hyperplasia 25 (50%) 17 (34%) 20 (40%) 13 (26%)
Hypertrophy 9 (18%) 14 (28%) 8 (16%) 14 (28%)
Inflammation, Granulomatous 1 (2%)
Necrosis 2 (4%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 4 (8%) 6 (12%) 4 (8%) 6 (12%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 11 (22%) 6 (12%) 9 (18%) 9 (18%)
Islets, Pancreatic (49) (50) (50) (50)
Hyperplasia 2 (4%) 1 (2%) 2 (4%)
Parathyroid Gland (48) (43) (43) (45)
Hyperplasia 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Hyperplasia 12 (24%) 16 (32%) 7 (14%) 12 (24%)
Thyroid Gland (48) (50) (49) (50)
C-Cell, Hyperplasia 40 (83%) 32 (64%) 38 (78%) 40 (80%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (48) (46) (48)
Hyperplasia 2 (4%) 4 (8%) 2 (4%) 3 (6%)
Inflammation, Chronic Active 1 (2%)
Ovary (50) (50) (50) (50)
Cyst 5 (10%) 3 (6%) 5 (10%) 6 (12%)
Inflammation, Granulomatous 1 (2%) 2 (4%)
Uterus (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (50) (50)
Atrophy 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Reticulum Cell 1 (2%)
Myelofibrosis 1 (2%) 1 (2%)
Spleen (50) (50) (50) (50)
Fibrosis 4 (8%) 6 (12%) 10 (20%) 4 (8%)
Hematopoietic Cell Proliferation 4 (8%) 5 (10%) 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 4 (8%)
Metaplasia, Osseous 1 (2%)
Necrosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 2 (4%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%)
Hyperostosis 6 (12%) 8 (16%) 11 (22%) 8 (16%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Degeneration, Focal 1 (2%) 1 (2%)
Gliosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Inflammation, Chronic Active 31 (62%) 29 (58%) 25 (50%) 19 (38%)
Alveolar Epithelium, Hyperplasia 5 (10%) 5 (10%) 10 (20%) 8 (16%)
Nose (50) (50) (50) (50)
Foreign Body 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Inflammation, Suppurative 5 (10%) 8 (16%) 8 (16%) 12 (24%)
Thrombosis 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Olfactory Epithelium, Atrophy 1 (2%) 2 (4%) 2 (4%)
Olfactory Epithelium, Hyperplasia 1 (2%)
Olfactory Epithelium, Metaplasia 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (4) (3) (6)
Cataract 5 (100%) 3 (75%) 3 (100%) 4 (67%)
Degeneration 1 (25%) 1 (17%)
Hemorrhage 1 (17%)
Retina, Atrophy 5 (100%) 2 (50%) 3 (100%) 4 (67%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (50)
Cyst 1 (2%) 1 (2%)
Hydronephrosis 1 (2%)
Infarct 1 (2%) 1 (2%)
Nephropathy 46 (92%) 47 (96%) 48 (96%) 47 (94%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Hyperplasia 4 (8%)
Renal Tubule, Necrosis 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 28 29 30 30
Natural Death 4 5 5 5
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 18 16 14 15
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (47) (49) (46) (50)
Inflammation, Acute 2 (4%)
Intestine Large, Cecum (48) (47) (46) (50)
Diverticulum 1 (2%)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%)
Intestine Small, Duodenum (49) (49) (48) (49)
Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Necrosis 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Intestine Small, Ileum (46) (47) (47) (49)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 5 (10%) 3 (6%)
Basophilic Focus 17 (34%) 13 (26%) 13 (26%) 16 (32%)
Clear Cell Focus 6 (12%) 9 (18%) 7 (14%) 8 (16%)
Degeneration, Cystic 9 (18%) 9 (18%) 14 (28%) 17 (34%)
Eosinophilic Focus 2 (4%) 4 (8%) 3 (6%) 3 (6%)
Fatty Change 15 (30%) 12 (24%) 9 (18%) 11 (22%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%) 1 (2%) 4 (8%) 4 (8%)
Infarct 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
Regeneration 2 (4%) 2 (4%) 6 (12%)
Artery, Inflammation, Chronic Active 1 (2%)
Bile Duct, Hyperplasia 25 (50%) 32 (64%) 36 (72%) 29 (58%)
Centrilobular, Necrosis 7 (14%) 11 (22%) 10 (20%) 9 (18%)
Mesentery (8) (12) (11) (11)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Thrombosis 1 (9%)
Artery, Mineralization 1 (9%) 2 (18%)
Fat, Hemorrhage 1 (13%) 1 (8%) 1 (9%) 1 (9%)
Fat, Inflammation, Chronic Active 1 (9%) 1 (9%)
Fat, Necrosis 6 (75%) 10 (83%) 8 (73%) 6 (55%)
Oral Mucosa (1) (1)
Pharyngeal, Hyperplasia, Squamous 1 (100%)
Pancreas (50) (50) (50) (50)
Atrophy 18 (36%) 23 (46%) 23 (46%) 15 (30%)
Basophilic Focus 1 (2%) 4 (8%) 1 (2%) 3 (6%)
Hyperplasia 4 (8%) 6 (12%) 9 (18%) 7 (14%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Fibrosis 1 (2%)
Hyperplasia, Squamous 1 (2%) 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Mineralization 2 (4%)
Necrosis 14 (28%) 8 (16%) 10 (20%) 12 (24%)
Stomach, Glandular (50) (50) (50) (50)
Mineralization 5 (10%) 1 (2%) 4 (8%) 4 (8%)
Necrosis 6 (12%) 3 (6%) 7 (14%) 9 (18%)
Tongue (1) (1)
Hyperplasia 1 (100%)
Tooth (1)
Developmental Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (2) (3)
Inflammation 1 (100%)
Aorta, Mineralization 2 (100%) 3 (100%)
Endothelium, Hyperplasia 1 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 41 (82%) 44 (88%) 44 (88%) 38 (76%)
Artery, Mineralization 1 (2%) 2 (4%) 4 (8%)
Atrium, Thrombosis 4 (8%) 3 (6%) 3 (6%) 5 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Degeneration, Cystic 1 (2%)
Hyperplasia 23 (46%) 23 (46%) 19 (38%) 20 (40%)
Hypertrophy 8 (16%) 11 (22%) 4 (8%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Necrosis 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 2 (4%) 6 (12%) 3 (6%) 6 (12%)
Adrenal Medulla (50) (50) (50) (50)
Angiectasis 1 (2%)
Hyperplasia 19 (38%) 19 (38%) 25 (50%) 21 (42%)
Thrombosis 1 (2%)
Bilateral, Hyperplasia 2 (4%)
Islets, Pancreatic (50) (50) (50) (49)
Hyperplasia 1 (2%) 3 (6%)
Parathyroid Gland (48) (46) (45) (47)
Cyst 1 (2%)
Hyperplasia 5 (10%) 6 (13%) 8 (18%) 13 (28%)
Pituitary Gland (50) (50) (50) (49)
Pars Distalis, Hyperplasia 5 (10%) 6 (12%) 9 (18%) 11 (22%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (49) (50) (49) (50)
C-Cell, Hyperplasia 30 (61%) 30 (60%) 30 (61%) 34 (68%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%) 1 (2%)
Preputial Gland (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic Active 3 (6%) 1 (2%) 1 (2%) 3 (6%)
Prostate (50) (50) (50) (50)
Hyperplasia 11 (22%) 13 (26%) 15 (30%) 17 (34%)
Inflammation, Chronic Active 5 (10%) 2 (4%) 1 (2%) 6 (12%)
Seminal Vesicle (47) (48) (47) (50)
Inflammation, Chronic Active 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active 6 (12%) 2 (4%) 1 (2%)
Interstitial Cell, Hyperplasia 15 (30%) 13 (26%) 8 (16%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50)
Hyperplasia, Histiocytic 1 (2%)
Myelofibrosis 1 (2%)
Necrosis 2 (4%)
Lymph Node (6) (7) (7) (9)
Iliac, Ectasia 1 (17%)
Renal, Hemorrhage 1 (11%)
Lymph Node, Mandibular (49) (46) (46) (44)
Infiltration Cellular, Plasma Cell 2 (4%)
Lymph Node, Mesenteric (50) (49) (49) (50)
Infiltration Cellular, Plasma Cell 1 (2%)
Spleen (50) (50) (50) (50)
Depletion Cellular 1 (2%)
Fibrosis 11 (22%) 14 (28%) 24 (48%) 22 (44%)
Hematopoietic Cell Proliferation 3 (6%) 3 (6%) 1 (2%) 5 (10%)
Hemorrhage 1 (2%)
Necrosis 3 (6%) 2 (4%) 1 (2%)
Thymus (47) (44) (49) (47)
Atrophy 1 (2%)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (42) (43) (47) (44)
Galactocele 2 (5%) 4 (9%) 2 (4%) 3 (7%)
Inflammation, Chronic 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 2 (4%) 2 (4%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 2 (4%) 1 (2%) 6 (12%) 7 (14%)
Hyperostosis 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Degeneration, Focal 1 (2%)
Gliosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Chronic Active 21 (43%) 16 (32%) 22 (44%) 15 (30%)
Mineralization 2 (4%) 2 (4%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 7 (14%) 11 (22%) 4 (8%) 10 (20%)
Artery, Mediastinum, Mineralization 2 (4%) 2 (4%)
Nose (50) (50) (49) (50)
Foreign Body 4 (8%) 4 (8%) 3 (6%) 2 (4%)
Inflammation, Suppurative 11 (22%) 9 (18%) 10 (20%) 9 (18%)
Thrombosis 2 (4%) 4 (8%) 10 (20%) 5 (10%)
Olfactory Epithelium, Atrophy 1 (2%) 8 (16%) 2 (4%)
Olfactory Epithelium, Metaplasia 7 (14%) 2 (4%) 1 (2%) 2 (4%)
Olfactory Epithelium, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Hyperplasia 2 (4%) 2 (4%) 2 (4%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Trachea (50) (50) (50) (50)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (3) (2)
Cataract 1 (100%) 1 (33%) 3 (100%) 2 (100%)
Hemorrhage 1 (33%)
Cornea, Inflammation, Chronic Active 1 (33%) 1 (33%)
Retina, Atrophy 1 (100%) 2 (67%) 3 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 2 (4%) 4 (8%) 2 (4%)
Infarct 1 (2%) 1 (2%) 2 (4%)
Mineralization 2 (4%) 3 (6%)
Nephropathy 50 (100%) 50 (100%) 50 (100%) 49 (98%)
Renal Tubule, Hyperplasia 2 (4%) 6 (12%) 8 (16%)
Urinary Bladder (50) (49) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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