TDMS Study 05135-07 Pathology Tables
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11
2 YEAR CHRONIC
Facility: Battelle Northwest
Chemical CAS #: 78-79-5
Lock Date: 03/13/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 5 5 4
Moribund Sacrifice 16 15 18 23
Survivors
Terminal Sacrifice 29 30 28 27
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Intestine Large, Colon (50) (48) (49) (50)
Intestine Large, Cecum (49) (47) (47) (50)
Intestine Small, Duodenum (49) (48) (50) (50)
Fibroma 1 (2%)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (9) (10) (8) (11)
Oral Mucosa (1) (1)
Pharyngeal, Squamous Cell Carcinoma 1 (100%)
Pancreas (50) (50) (50) (50)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (49) (50) (50)
Tongue (1) (2)
Squamous Cell Papilloma 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%)
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NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Benign 1 (2%) 5 (10%) 4 (8%) 3 (6%)
Islets, Pancreatic (49) (50) (50) (50)
Adenoma 1 (2%) 2 (4%)
Carcinoma 2 (4%) 1 (2%)
Parathyroid Gland (48) (43) (43) (45)
Pituitary Gland (50) (50) (50) (50)
Sarcoma, Metastatic, Brain 1 (2%)
Pars Distalis, Adenoma 33 (66%) 27 (54%) 36 (72%) 27 (54%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (48) (50) (49) (50)
C-Cell, Adenoma 6 (13%) 4 (8%) 2 (4%) 2 (4%)
C-Cell, Carcinoma 2 (4%) 4 (8%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (48) (46) (48)
Adenoma 3 (6%) 5 (10%) 5 (11%) 6 (13%)
Carcinoma 2 (4%) 4 (8%) 2 (4%) 2 (4%)
Bilateral, Carcinoma 1 (2%)
Ovary (50) (50) (50) (50)
Granulosa Cell Tumor Malignant 1 (2%) 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Uterus (50) (50) (50) (50)
Polyp Stromal 8 (16%) 4 (8%) 5 (10%) 7 (14%)
Polyp Stromal, Multiple 1 (2%) 1 (2%) 1 (2%)
Sarcoma Stromal 1 (2%) 1 (2%)
Endometrium, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (6) (4) (2)
Lymph Node, Bronchial (42) (37) (34) (35)
Lymph Node, Mandibular (45) (47) (49) (46)
Lymph Node, Mesenteric (50) (50) (50) (50)
Lymph Node, Mediastinal (44) (44) (42) (44)
Spleen (50) (50) (50) (50)
Page 3
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Sarcoma 1 (2%)
Thymus (48) (45) (39) (46)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Carcinoma 4 (8%) 2 (4%) 1 (2%) 3 (6%)
Fibroadenoma 12 (24%) 23 (46%) 13 (26%) 15 (30%)
Fibroadenoma, Multiple 7 (14%) 12 (24%) 19 (38%) 17 (34%)
Skin (50) (50) (50) (50)
Keratoacanthoma 1 (2%)
Squamous Cell Papilloma 2 (4%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Rhabdomyosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Benign 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 2 (4%) 1 (2%)
Glioma Malignant 1 (2%)
Medulloblastoma Mal 1 (2%)
Meninges, Granular Cell Tumor Benign 1 (2%) 1 (2%)
Meninges, Sarcoma 1 (2%) 1 (2%)
Spinal Cord (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Nose (50) (50) (50) (50)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
Pleura (1)
Page 4
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (50)
Mesenchymal Tumor Benign 1 (2%)
Sarcoma, Metastatic, Urinary Bladder 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 14 (28%) 15 (30%) 21 (42%) 21 (42%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 48 49 48
Total Primary Neoplasms 109 121 124 120
Total Animals with Benign Neoplasms 43 43 46 41
Total Benign Neoplasms 79 90 94 84
Total Animals with Malignant Neoplasms 28 27 26 31
Total Malignant Neoplasms 30 31 30 36
Total Animals with Metastatic Neoplasms 2 4 1
Total Metastatic Neoplasm 2 4 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 28 29 30 30
Natural Death 4 5 5 5
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 18 16 14 15
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (49) (47) (50)
Intestine Large, Rectum (47) (49) (46) (50)
Anus, Leiomyoma 1 (2%)
Anus, Squamous Cell Papilloma 1 (2%)
Intestine Large, Cecum (48) (47) (46) (50)
Intestine Small, Jejunum (46) (46) (47) (47)
Carcinoma 1 (2%)
Intestine Small, Ileum (46) (47) (47) (49)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 2 (4%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mesentery (8) (12) (11) (11)
Oral Mucosa (1) (1)
Gingival, Sarcoma 1 (100%)
Pancreas (50) (50) (50) (50)
Adenoma 3 (6%) 1 (2%) 3 (6%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Leiomyosarcoma 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Carcinoid Tumor Benign 1 (2%)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 3 (6%) 1 (2%) 1 (2%)
Pheochromocytoma Benign 13 (26%) 11 (22%) 16 (32%) 15 (30%)
Bilateral, Pheochromocytoma Benign 5 (10%) 4 (8%) 4 (8%) 3 (6%)
Islets, Pancreatic (50) (50) (50) (49)
Adenoma 1 (2%) 2 (4%) 5 (10%) 1 (2%)
Carcinoma 2 (4%) 1 (2%) 1 (2%)
Parathyroid Gland (48) (46) (45) (47)
Adenoma 1 (2%)
Pituitary Gland (50) (50) (50) (49)
Pars Distalis, Adenoma 39 (78%) 40 (80%) 39 (78%) 31 (63%)
Thyroid Gland (49) (50) (49) (50)
C-Cell, Adenoma 3 (6%) 4 (8%) 3 (6%) 3 (6%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2) (1) (3)
Tissue NOS (1) (2)
Osteosarcoma 1 (50%)
Sarcoma 1 (50%)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (50) (50) (50) (50)
Adenoma 2 (4%) 1 (2%) 3 (6%) 3 (6%)
Carcinoma 3 (6%) 2 (4%) 2 (4%)
Prostate (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Seminal Vesicle (47) (48) (47) (50)
Testes (50) (50) (50) (50)
Page 8
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Bilateral, Interstitial Cell, Adenoma 20 (40%) 29 (58%) 37 (74%) 48 (96%)
Interstitial Cell, Adenoma 13 (26%) 8 (16%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50)
Lymph Node (6) (7) (7) (9)
Lymph Node, Bronchial (44) (39) (42) (35)
Histiocytic Sarcoma 1 (3%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (3%)
Lymph Node, Mandibular (49) (46) (46) (44)
Lymph Node, Mesenteric (50) (49) (49) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mediastinal (46) (44) (45) (44)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Sarcoma 1 (2%)
Thymus (47) (44) (49) (47)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (42) (43) (47) (44)
Carcinoma 1 (2%) 1 (2%) 2 (5%)
Fibroadenoma 1 (2%) 3 (7%) 6 (13%) 14 (32%)
Fibroadenoma, Multiple 1 (2%) 1 (2%) 7 (16%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Keratoacanthoma 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Lipoma 1 (2%) 1 (2%)
Squamous Cell Carcinoma 1 (2%) 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Trichoepithelioma 1 (2%)
Pinna, Melanoma Malignant 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteoma 1 (2%)
Osteosarcoma 1 (2%)
Vertebra, Chordoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma 1 (2%) 3 (6%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Chordoma, Metastatic, Bone 1 (2%)
Histiocytic Sarcoma 1 (2%)
Melanoma Malignant, Metastatic, Skin 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Nose (50) (50) (49) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1) (1)
Carcinoma 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Lipoma 1 (2%)
Mesenchymal Tumor Benign 1 (2%)
Renal Tubule, Adenoma 2 (4%) 2 (4%) 6 (12%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (49) (50) (50)
Page 10
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 24 (48%) 26 (52%) 25 (50%) 25 (50%)
Mesothelioma Benign 2 (4%) 2 (4%) 1 (2%)
Mesothelioma Malignant 3 (6%) 1 (2%) 1 (2%) 4 (8%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 49 48
Total Primary Neoplasms 150 166 174 184
Total Animals with Benign Neoplasms 49 50 49 48
Total Benign Neoplasms 108 125 135 139
Total Animals with Malignant Neoplasms 34 33 30 34
Total Malignant Neoplasms 42 41 39 45
Total Animals with Metastatic Neoplasms 2 5
Total Metastatic Neoplasm 3 6
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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