TDMS Study 05135-07 Pathology Tables
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11 2 YEAR CHRONIC Facility: Battelle Northwest Chemical CAS #: 78-79-5 Lock Date: 03/13/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Natural Death 5 5 4 Moribund Sacrifice 16 15 18 23 Survivors Terminal Sacrifice 29 30 28 27 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (50) (50) (50) Intestine Large, Colon (50) (48) (49) (50) Intestine Large, Cecum (49) (47) (47) (50) Intestine Small, Duodenum (49) (48) (50) (50) Fibroma 1 (2%) Liver (50) (50) (50) (50) Hepatocellular Carcinoma 1 (2%) Hepatocellular Adenoma 1 (2%) Histiocytic Sarcoma 1 (2%) Mesentery (9) (10) (8) (11) Oral Mucosa (1) (1) Pharyngeal, Squamous Cell Carcinoma 1 (100%) Pancreas (50) (50) (50) (50) Salivary Glands (50) (50) (50) (50) Stomach, Forestomach (50) (50) (50) (50) Squamous Cell Papilloma 1 (2%) Stomach, Glandular (50) (49) (50) (50) Tongue (1) (2) Squamous Cell Papilloma 1 (100%) 1 (50%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Schwannoma Benign 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Adenoma 2 (4%) 1 (2%) 2 (4%) 1 (2%) Adrenal Medulla (50) (50) (50) (50) Pheochromocytoma Malignant 1 (2%) Page 2 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Pheochromocytoma Benign 1 (2%) 5 (10%) 4 (8%) 3 (6%) Islets, Pancreatic (49) (50) (50) (50) Adenoma 1 (2%) 2 (4%) Carcinoma 2 (4%) 1 (2%) Parathyroid Gland (48) (43) (43) (45) Pituitary Gland (50) (50) (50) (50) Sarcoma, Metastatic, Brain 1 (2%) Pars Distalis, Adenoma 33 (66%) 27 (54%) 36 (72%) 27 (54%) Pars Distalis, Carcinoma 1 (2%) 1 (2%) Thyroid Gland (48) (50) (49) (50) C-Cell, Adenoma 6 (13%) 4 (8%) 2 (4%) 2 (4%) C-Cell, Carcinoma 2 (4%) 4 (8%) 2 (4%) Follicular Cell, Adenoma 1 (2%) Follicular Cell, Carcinoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (47) (48) (46) (48) Adenoma 3 (6%) 5 (10%) 5 (11%) 6 (13%) Carcinoma 2 (4%) 4 (8%) 2 (4%) 2 (4%) Bilateral, Carcinoma 1 (2%) Ovary (50) (50) (50) (50) Granulosa Cell Tumor Malignant 1 (2%) 1 (2%) Granulosa Cell Tumor Benign 1 (2%) Uterus (50) (50) (50) (50) Polyp Stromal 8 (16%) 4 (8%) 5 (10%) 7 (14%) Polyp Stromal, Multiple 1 (2%) 1 (2%) 1 (2%) Sarcoma Stromal 1 (2%) 1 (2%) Endometrium, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (49) (50) (50) Histiocytic Sarcoma 1 (2%) Lymph Node (6) (4) (2) Lymph Node, Bronchial (42) (37) (34) (35) Lymph Node, Mandibular (45) (47) (49) (46) Lymph Node, Mesenteric (50) (50) (50) (50) Lymph Node, Mediastinal (44) (44) (42) (44) Spleen (50) (50) (50) (50) Page 3 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Sarcoma 1 (2%) Thymus (48) (45) (39) (46) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Carcinoma 4 (8%) 2 (4%) 1 (2%) 3 (6%) Fibroadenoma 12 (24%) 23 (46%) 13 (26%) 15 (30%) Fibroadenoma, Multiple 7 (14%) 12 (24%) 19 (38%) 17 (34%) Skin (50) (50) (50) (50) Keratoacanthoma 1 (2%) Squamous Cell Papilloma 2 (4%) 1 (2%) Sebaceous Gland, Adenoma 1 (2%) Subcutaneous Tissue, Fibroma 1 (2%) Subcutaneous Tissue, Fibrosarcoma 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (1) Rhabdomyosarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Astrocytoma Benign 1 (2%) Carcinoma, Metastatic, Pituitary Gland 2 (4%) 1 (2%) Glioma Malignant 1 (2%) Medulloblastoma Mal 1 (2%) Meninges, Granular Cell Tumor Benign 1 (2%) 1 (2%) Meninges, Sarcoma 1 (2%) 1 (2%) Spinal Cord (1) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Nose (50) (50) (50) (50) Squamous Cell Carcinoma, Metastatic, Oral Mucosa 1 (2%) Pleura (1) Page 4 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (49) (50) (50) Mesenchymal Tumor Benign 1 (2%) Sarcoma, Metastatic, Urinary Bladder 1 (2%) Renal Tubule, Adenoma 1 (2%) Urinary Bladder (50) (50) (50) (50) Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) Leukemia Mononuclear 14 (28%) 15 (30%) 21 (42%) 21 (42%) Mesothelioma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 49 48 49 48 Total Primary Neoplasms 109 121 124 120 Total Animals with Benign Neoplasms 43 43 46 41 Total Benign Neoplasms 79 90 94 84 Total Animals with Malignant Neoplasms 28 27 26 31 Total Malignant Neoplasms 30 31 30 36 Total Animals with Metastatic Neoplasms 2 4 1 Total Metastatic Neoplasm 2 4 1 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Moribund Sacrifice 28 29 30 30 Natural Death 4 5 5 5 Survivors Moribund Sacrifice 1 Terminal Sacrifice 18 16 14 15 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (49) (49) (47) (50) Intestine Large, Rectum (47) (49) (46) (50) Anus, Leiomyoma 1 (2%) Anus, Squamous Cell Papilloma 1 (2%) Intestine Large, Cecum (48) (47) (46) (50) Intestine Small, Jejunum (46) (46) (47) (47) Carcinoma 1 (2%) Intestine Small, Ileum (46) (47) (47) (49) Liver (50) (50) (50) (50) Hepatocellular Carcinoma 1 (2%) Hepatocellular Adenoma 2 (4%) Histiocytic Sarcoma 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Mesentery (8) (12) (11) (11) Oral Mucosa (1) (1) Gingival, Sarcoma 1 (100%) Pancreas (50) (50) (50) (50) Adenoma 3 (6%) 1 (2%) 3 (6%) Salivary Glands (50) (50) (50) (50) Stomach, Forestomach (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) Leiomyosarcoma 1 (2%) Stomach, Glandular (50) (50) (50) (50) Carcinoid Tumor Benign 1 (2%) Tongue (1) (1) Squamous Cell Papilloma 1 (100%) ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Adenoma 1 (2%) Carcinoma 1 (2%) Adrenal Medulla (50) (50) (50) (50) Pheochromocytoma Malignant 3 (6%) 1 (2%) 1 (2%) Pheochromocytoma Benign 13 (26%) 11 (22%) 16 (32%) 15 (30%) Bilateral, Pheochromocytoma Benign 5 (10%) 4 (8%) 4 (8%) 3 (6%) Islets, Pancreatic (50) (50) (50) (49) Adenoma 1 (2%) 2 (4%) 5 (10%) 1 (2%) Carcinoma 2 (4%) 1 (2%) 1 (2%) Parathyroid Gland (48) (46) (45) (47) Adenoma 1 (2%) Pituitary Gland (50) (50) (50) (49) Pars Distalis, Adenoma 39 (78%) 40 (80%) 39 (78%) 31 (63%) Thyroid Gland (49) (50) (49) (50) C-Cell, Adenoma 3 (6%) 4 (8%) 3 (6%) 3 (6%) C-Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%) 3 (6%) Follicular Cell, Adenoma 1 (2%) 1 (2%) 1 (2%) Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Peritoneum (2) (1) (3) Tissue NOS (1) (2) Osteosarcoma 1 (50%) Sarcoma 1 (50%) Schwannoma Malignant 1 (100%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Preputial Gland (50) (50) (50) (50) Adenoma 2 (4%) 1 (2%) 3 (6%) 3 (6%) Carcinoma 3 (6%) 2 (4%) 2 (4%) Prostate (50) (50) (50) (50) Adenoma 1 (2%) Carcinoma 1 (2%) Seminal Vesicle (47) (48) (47) (50) Testes (50) (50) (50) (50) Page 8 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont Bilateral, Interstitial Cell, Adenoma 20 (40%) 29 (58%) 37 (74%) 48 (96%) Interstitial Cell, Adenoma 13 (26%) 8 (16%) 7 (14%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (49) (50) Lymph Node (6) (7) (7) (9) Lymph Node, Bronchial (44) (39) (42) (35) Histiocytic Sarcoma 1 (3%) Pheochromocytoma Malignant, Metastatic, Adrenal Medulla 1 (3%) Lymph Node, Mandibular (49) (46) (46) (44) Lymph Node, Mesenteric (50) (49) (49) (50) Histiocytic Sarcoma 1 (2%) Lymph Node, Mediastinal (46) (44) (45) (44) Histiocytic Sarcoma 1 (2%) Spleen (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) Sarcoma 1 (2%) Thymus (47) (44) (49) (47) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (42) (43) (47) (44) Carcinoma 1 (2%) 1 (2%) 2 (5%) Fibroadenoma 1 (2%) 3 (7%) 6 (13%) 14 (32%) Fibroadenoma, Multiple 1 (2%) 1 (2%) 7 (16%) Skin (50) (50) (50) (50) Basal Cell Adenoma 1 (2%) 1 (2%) 1 (2%) 1 (2%) Keratoacanthoma 1 (2%) 2 (4%) 1 (2%) 2 (4%) Lipoma 1 (2%) 1 (2%) Squamous Cell Carcinoma 1 (2%) 1 (2%) 1 (2%) Squamous Cell Papilloma 1 (2%) Trichoepithelioma 1 (2%) Pinna, Melanoma Malignant 1 (2%) Sebaceous Gland, Adenoma 1 (2%) Subcutaneous Tissue, Fibroma 4 (8%) 1 (2%) 2 (4%) Subcutaneous Tissue, Fibrosarcoma 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) Subcutaneous Tissue, Schwannoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ Page 9 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Osteoma 1 (2%) Osteosarcoma 1 (2%) Vertebra, Chordoma 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Astrocytoma Malignant 1 (2%) Granular Cell Tumor Benign 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (50) (50) (50) Alveolar/Bronchiolar Carcinoma 1 (2%) 3 (6%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Chordoma, Metastatic, Bone 1 (2%) Histiocytic Sarcoma 1 (2%) Melanoma Malignant, Metastatic, Skin 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Osteosarcoma, Metastatic, Uncertain Primary Site 1 (2%) Pheochromocytoma Malignant, Metastatic, Adrenal Medulla 1 (2%) Squamous Cell Carcinoma 1 (2%) Mediastinum, Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Nose (50) (50) (49) (50) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) (1) (1) Carcinoma 1 (100%) 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Lipoma 1 (2%) Mesenchymal Tumor Benign 1 (2%) Renal Tubule, Adenoma 2 (4%) 2 (4%) 6 (12%) Renal Tubule, Carcinoma 1 (2%) Urinary Bladder (50) (49) (50) (50) Page 10 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) Leukemia Mononuclear 24 (48%) 26 (52%) 25 (50%) 25 (50%) Mesothelioma Benign 2 (4%) 2 (4%) 1 (2%) Mesothelioma Malignant 3 (6%) 1 (2%) 1 (2%) 4 (8%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 11 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:55:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 50 50 49 48 Total Primary Neoplasms 150 166 174 184 Total Animals with Benign Neoplasms 49 50 49 48 Total Benign Neoplasms 108 125 135 139 Total Animals with Malignant Neoplasms 34 33 30 34 Total Malignant Neoplasms 42 41 39 45 Total Animals with Metastatic Neoplasms 2 5 Total Metastatic Neoplasm 3 6 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------