TDMS Study 05135-07 Pathology Tables
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
2 YEAR CHRONIC
Facility: Battelle Northwest
Chemical CAS #: 78-79-5
Lock Date: 03/13/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 3| 7| 7| 5|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 9| 3| 3| 8|
| 0| 4| 4| 5| 5| 5| 5| 6| 2| 4| 4| 4| 6| 5| 2| 6| 4| 5| 4| 4| 4| 8| 4| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X |
Fatty Change | 2 2 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X X X |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 1 2 2 2 2 |
Basophilic Focus | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 1 1 2 1 1 2 1 2 1 2 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2|
Hypertrophy | 2 2 2 2 1 |
Necrosis | |
Vacuolization Cytoplasmic | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 3| 7| 7| 5|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 9| 3| 3| 8|
| 0| 4| 4| 5| 5| 5| 5| 6| 2| 4| 4| 4| 6| 5| 2| 6| 4| 5| 4| 4| 4| 8| 4| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 2 2 2 4 |
__________________________________________________________________________|
Thyroid Gland | A + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 2 2 2 1 1 1 2 1 2 1 1 1 1 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + M M + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + M + + + + + M + + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + M + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2|
Hematopoietic Cell Proliferation | 3 3 3 |
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 3| 7| 7| 5|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 9| 3| 3| 8|
| 0| 4| 4| 5| 5| 5| 5| 6| 2| 4| 4| 4| 6| 5| 2| 6| 4| 5| 4| 4| 4| 8| 4| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Fibrous Osteodystrophy | |
Hyperostosis | 3 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 3 2 1 2 2 2 2 2 2 3 3 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 2 1 2 |
Thrombosis | 2|
Olfactory Epithelium, Metaplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 4 |
Retina, Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Nephropathy | 2 3 2 1 2 2 2 2 1 2 1 2 2 2 1 2 2 2 2 2 3 2 1|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 5| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 2| 2| 3| 5| 7| 0| 5| 3| 8| 4| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 7| |
| 9| 6| 7| 8| 6| 7| 1| 5| 7| 4| 0| 8| 6| 9| 4| 4| 7| 4| 6| 5| 4| 5| 5| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + I + + + + + + + M + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 3 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X | 36 |
Clear Cell Focus | X X X X X X | 9 |
Eosinophilic Focus | X | 2 |
Fatty Change | 3 1 2 3 1 3| 8 2.1|
Hepatodiaphragmatic Nodule | X | 2 |
Mixed Cell Focus | X | 4 |
Bile Duct, Cyst | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 1 1 | 3 1.3|
Centrilobular, Necrosis | 1 1 3 1 1| 5 1.4|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Fat, Necrosis | 2 2 2 2 2 | 9 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 3 1 4 1 2 1 1 1| 18 1.8|
Basophilic Focus | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 3 3 3| 5 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 1 2 1 2 2 2 1 2 1 2 1 1 2 | 35 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 | 1 3.0|
Hyperplasia | 2 2 2 2 1 2 1 2 2 2 2 2 2 2 | 25 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 5| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 2| 2| 3| 5| 7| 0| 5| 3| 8| 4| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 7| |
| 9| 6| 7| 8| 6| 7| 1| 5| 7| 4| 0| 8| 6| 9| 4| 4| 7| 4| 6| 5| 4| 5| 5| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy | 1 1 3 2 | 9 1.8|
Necrosis | 2 3 | 2 2.5|
Vacuolization Cytoplasmic | | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 2 3 2 2 3 2 2 | 11 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + M + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 2 2 2 3 2 | 12 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 1 1 1 2 3 1 1 1 1 1 1 2 3 2 2 1 1 2 2 2 4| 40 1.6|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 2 | 5 2.6|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + + + + + M + M M + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + M + + + + M + + + M + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + + + + + + M + + M + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 1 2 | 4 1.8|
Hematopoietic Cell Proliferation | 3 | 4 3.0|
Hemorrhage | 2 | 1 2.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M M + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 5| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 2| 2| 3| 5| 7| 0| 5| 3| 8| 4| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 7| |
| 9| 6| 7| 8| 6| 7| 1| 5| 7| 4| 0| 8| 6| 9| 4| 4| 7| 4| 6| 5| 4| 5| 5| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 | 1 4.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 1 1.0|
Hyperostosis | 3 4 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 1 1 2 1 2 1 2 2 1 1 2 1 | 31 1.8|
Alveolar Epithelium, Hyperplasia | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Inflammation, Suppurative | 1 2 | 5 1.6|
Thrombosis | 3 | 2 2.5|
Olfactory Epithelium, Metaplasia | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 5 |
Cataract | 3 3 3 | 5 3.0|
Retina, Atrophy | 3 4 4 | 5 3.4|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 1.0|
Nephropathy | 2 1 4 1 2 2 1 3 3 1 2 1 2 1 2 3 1 2 2 4 2 3 1| 46 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 5| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 2| 2| 3| 5| 7| 0| 5| 3| 8| 4| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 7| |
| 9| 6| 7| 8| 6| 7| 1| 5| 7| 4| 0| 8| 6| 9| 4| 4| 7| 4| 6| 5| 4| 5| 5| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Hyperplasia | 3 2 1 2 | 4 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 0| 3| 3| 7| 0| 3| 3| 8| 8| 3| 3| 3| 3| 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 9| 2|
| 1| 6| 6| 0| 2| 4| 6| 7| 5| 4| 5| 5| 6| 2| 5| 5| 5| 5| 6| 5| 4| 6| 6| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
220 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + I +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X |
Degeneration, Cystic | 2 |
Degeneration, Fatty | |
Eosinophilic Focus | |
Fatty Change | 2 2 3 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X X X |
Regeneration | |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 1 2 1 2 2 1 |
Centrilobular, Necrosis | 2 1 2 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 1 1 1 2 |
Hyperplasia | 3|
Metaplasia, Hepatocyte | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Necrosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 2 2 1 1 2 2 1 2 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | 1 |
Hyperplasia | 2 2 3 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 0| 3| 3| 7| 0| 3| 3| 8| 8| 3| 3| 3| 3| 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 9| 2|
| 1| 6| 6| 0| 2| 4| 6| 7| 5| 4| 5| 5| 6| 2| 5| 5| 5| 5| 6| 5| 4| 6| 6| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
220 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | 2 1 2 2 1 1 |
Inflammation, Granulomatous | 2 |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + I + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 3 2 3 1 3 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 4 4 2 1 1 2 2 4 1 1 2 2 1|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + M + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + M + + + + + + + + + + + + + M + M M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + M + M M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 |
Hematopoietic Cell Proliferation | 3 3 3|
Hemorrhage | |
Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Thymus | + + + M + + M + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 0| 3| 3| 7| 0| 3| 3| 8| 8| 3| 3| 3| 3| 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 9| 2|
| 1| 6| 6| 0| 2| 4| 6| 7| 5| 4| 5| 5| 6| 2| 5| 5| 5| 5| 6| 5| 4| 6| 6| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
220 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 2 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Suppurative | 2 2 1 1 |
Thrombosis | 1 |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 3 |
Degeneration | |
Retina, Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct | 3 |
Nephropathy | 1 1 1 1 1 2 2 1 2 2 2 1 1 2 2 2 3 2 2 1 1 2 2 2|
Papilla, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 9| 3| 7| 6| 3| 3| 3| 3| 8| 7| 3| 2| 3| 4| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| |
| 6| 3| 5| 0| 4| 4| 6| 6| 6| 6| 0| 8| 7| 5| 3| 6| 6| 5| 5| 4| 4| 6| 4| 2| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
220 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.5|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 38 |
Clear Cell Focus | X X X X X X| 11 |
Degeneration, Cystic | | 1 2.0|
Degeneration, Fatty | 3 | 1 3.0|
Eosinophilic Focus | X X X | 3 |
Fatty Change | 3 2 2 | 6 2.3|
Hepatodiaphragmatic Nodule | X | 4 |
Mixed Cell Focus | X X X X X X X | 10 |
Regeneration | 2 | 1 2.0|
Bile Duct, Cyst | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 2 | 9 1.4|
Centrilobular, Necrosis | 1 | 5 1.4|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 10 |
Fat, Necrosis | 2 2 2 2 2 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 1 1 1 1 1 | 13 1.4|
Hyperplasia | 2 | 2 2.5|
Metaplasia, Hepatocyte | 1 | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X | 1 |
Necrosis | 4 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 1 1 2 2 1 2 1 1 2 1 1 1 1 1 2| 33 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 9| 3| 7| 6| 3| 3| 3| 3| 8| 7| 3| 2| 3| 4| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| |
| 6| 3| 5| 0| 4| 4| 6| 6| 6| 6| 0| 8| 7| 5| 3| 6| 6| 5| 5| 4| 4| 6| 4| 2| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
220 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Tissue | | 1 1.0|
Hyperplasia | 2 2 2 2 2 2 2 | 17 2.0|
Hypertrophy | 2 2 2 3 1 2 1 3| 14 1.8|
Inflammation, Granulomatous | | 1 2.0|
Vacuolization Cytoplasmic | 2 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 | 6 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + M + + + M + + M + + + + + + M + M| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 3 3 2 3 1 2 3 4 | 16 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 4 1 2 1 2 1 2 1 2 1 1 1 1 | 32 1.7|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 2 3 | 4 2.5|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 3 1.7|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Histiocytic | 2 | 1 2.0|
Hyperplasia, Reticulum Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + M + M + + + + + + M + M + + M + M| 37 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + + + + + M +| 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 9| 3| 7| 6| 3| 3| 3| 3| 8| 7| 3| 2| 3| 4| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| |
| 6| 3| 5| 0| 4| 4| 6| 6| 6| 6| 0| 8| 7| 5| 3| 6| 6| 5| 5| 4| 4| 6| 4| 2| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
220 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 1 2 2 | 6 1.7|
Hematopoietic Cell Proliferation | 3 3 | 5 3.0|
Hemorrhage | 2 2 | 2 2.0|
Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + + + M + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 1 1 3 | 8 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 29 1.1|
Alveolar Epithelium, Hyperplasia | 3 2 1 | 5 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Suppurative | 3 2 1 1| 8 1.6|
Thrombosis | 2 | 2 1.5|
Olfactory Epithelium, Atrophy | | 1 1.0|
Olfactory Epithelium, Metaplasia | 3 | 2 2.5|
Respiratory Epithelium, Hyperplasia | 1| 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 9| 3| 7| 6| 3| 3| 3| 3| 8| 7| 3| 2| 3| 4| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| |
| 6| 3| 5| 0| 4| 4| 6| 6| 6| 6| 0| 8| 7| 5| 3| 6| 6| 5| 5| 4| 4| 6| 4| 2| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
220 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cataract | 1 | 3 2.0|
Degeneration | 3 | 1 3.0|
Retina, Atrophy | | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | 3 | 1 3.0|
Infarct | | 1 3.0|
Nephropathy | 2 2 2 2 2 2 2 1 2 1 2 3 1 2 1 2 1 1 2 2 3 1 2| 47 1.7|
Papilla, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 1| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 5|
DAY ON TEST | 6| 0| 3| 3| 3| 1| 3| 3| 1| 1| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 9| 8| 4|
| 6| 8| 5| 5| 5| 1| 5| 5| 7| 3| 5| 0| 4| 7| 6| 4| 4| 5| 6| 5| 0| 6| 9| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
700 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + A A +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X |
Eosinophilic Focus | X |
Fatty Change | 3 3|
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X X X X X X |
Regeneration | |
Bile Duct, Hyperplasia | 2 1 2 1 |
Centrilobular, Necrosis | 1 1 1 |
Periportal, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 2 3 |
__________________________________________________________________________|
Oral Mucosa | |
Pharyngeal, Hyperplasia, Squamous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 1 1 2 |
Basophilic Focus | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Necrosis | 4 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Necrosis | 2 |
__________________________________________________________________________|
Tongue | + |
Hyperplasia | 1 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 1 1 2 1 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 1| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 5|
DAY ON TEST | 6| 0| 3| 3| 3| 1| 3| 3| 1| 1| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 9| 8| 4|
| 6| 8| 5| 5| 5| 1| 5| 5| 7| 3| 5| 0| 4| 7| 6| 4| 4| 5| 6| 5| 0| 6| 9| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
700 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Hyperplasia | 2 1 4 1 1 2 1 2 |
Hypertrophy | 3 3 1 1 2|
Vacuolization Cytoplasmic | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + M + + + + + M + + + + + M + M + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 3 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 3 2 1 2 1 1 4 2 1 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + M + M + M M + + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 1 2 2 |
Hemorrhage | 2 2|
__________________________________________________________________________|
Thymus | + + + M + + + M M + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 1| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 5|
DAY ON TEST | 6| 0| 3| 3| 3| 1| 3| 3| 1| 1| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 9| 8| 4|
| 6| 8| 5| 5| 5| 1| 5| 5| 7| 3| 5| 0| 4| 7| 6| 4| 4| 5| 6| 5| 0| 6| 9| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
700 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 3 4 2 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 1 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Suppurative | 3 1 1 1 |
Thrombosis | |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Hyperplasia | 3 |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy | 1 2 1 2 2 2 2 1 2 3 2 2 1 1 2 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 8| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 1| 3| 0| 3| 0| 7| 3| 3| |
| 5| 6| 1| 6| 7| 1| 4| 6| 5| 5| 4| 9| 3| 1| 8| 5| 6| 0| 6| 4| 5| 8| 2| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
700 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + I + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 3 1.7|
Basophilic Focus | X X X X X X X X X X X X X X X X| 33 |
Clear Cell Focus | X X X X X | 10 |
Eosinophilic Focus | | 1 |
Fatty Change | 3 2 2 3 3 2 1 1 1 | 11 2.2|
Hepatodiaphragmatic Nodule | X X | 5 |
Mixed Cell Focus | X X X X | 10 |
Regeneration | 2 2 | 2 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 2 | 9 1.8|
Centrilobular, Necrosis | 3 1 1 1 1 | 8 1.3|
Periportal, Infiltration Cellular, | | |
Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Fat, Necrosis | 2 2 2 2 2 | 8 2.1|
__________________________________________________________________________|____________|
Oral Mucosa | +| 1 |
Pharyngeal, Hyperplasia, Squamous | 4| 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 2 2 3 1 | 11 1.8|
Basophilic Focus | X X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 | 1 2.0|
Necrosis | 3 3 3 3 1 | 7 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
Necrosis | 3 2 1 | 4 2.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 8| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 1| 3| 0| 3| 0| 7| 3| 3| |
| 5| 6| 1| 6| 7| 1| 4| 6| 5| 5| 4| 9| 3| 1| 8| 5| 6| 0| 6| 4| 5| 8| 2| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
700 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 2 2 2 1 2 1 2 1 3 1 1| 28 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | | 1 3.0|
Hyperplasia | 2 2 2 2 3 2 2 2 2 2 1 2| 20 1.9|
Hypertrophy | 2 2 2 | 8 2.0|
Vacuolization Cytoplasmic | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 1 | 9 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + M| 43 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 3 3 | 7 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 2 2 2 2 2 1 2 1 1 2 1 1 1 2 2 1 1 1 1| 38 1.5|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + M + M + + + + + + + +| 46 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 3 | 5 2.2|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + M M M M M + + + M + M + M M + + + +| 34 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 8| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 1| 3| 0| 3| 0| 7| 3| 3| |
| 5| 6| 1| 6| 7| 1| 4| 6| 5| 5| 4| 9| 3| 1| 8| 5| 6| 0| 6| 4| 5| 8| 2| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
700 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + + + M + + M + M M + + + M + + + +| 42 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 3 1 2 2 | 10 1.8|
Hemorrhage | 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Thymus | + + M + + + M + M M M M + + + + + + + + + + + + M| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 3 2 2 4 | 11 2.6|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 25 1.1|
Alveolar Epithelium, Hyperplasia | 1 2 1 1 1 2 | 10 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Suppurative | 1 1 2 1 | 8 1.4|
Thrombosis | 2 3 3 | 3 2.7|
Olfactory Epithelium, Atrophy | 1 2 | 2 1.5|
Olfactory Epithelium, Hyperplasia | | 1 3.0|
Olfactory Epithelium, Metaplasia | 2 | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | 3 | 3 3.0|
Retina, Atrophy | 4 | 3 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 8| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 1| 3| 0| 3| 0| 7| 3| 3| |
| 5| 6| 1| 6| 7| 1| 4| 6| 5| 5| 4| 9| 3| 1| 8| 5| 6| 0| 6| 4| 5| 8| 2| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
700 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 | 1 2.0|
Nephropathy | 3 2 1 2 1 2 2 2 2 2 3 1 1 3 1 2 1 2 4 2 2 2 3 2 2| 48 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 4| 7| 6| 6| 6| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 1| 6| 3| 3| 3| 3| 1| 3| 2| 6| 2| 3| 3| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 9| 3|
| 4| 4| 6| 5| 2| 6| 5| 4| 1| 4| 5| 5| 5| 5| 5| 7| 5| 6| 2| 4| 5| 4| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X X |
Fatty Change | 2 |
Fibrosis | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | 2 |
Mixed Cell Focus | X X X |
Necrosis | 1 |
Regeneration | 2 4 |
Bile Duct, Hyperplasia | 1 2 1 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 2 2 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 1 1 2 2 |
Basophilic Focus | X X |
Metaplasia, Hepatocyte | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 1 1 1 1 1 1 2 2 2 1 1 2 1 2|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 4| 7| 6| 6| 6| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 1| 6| 3| 3| 3| 3| 1| 3| 2| 6| 2| 3| 3| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 9| 3|
| 4| 4| 6| 5| 2| 6| 5| 4| 1| 4| 5| 5| 5| 5| 5| 7| 5| 6| 2| 4| 5| 4| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Cystic | |
Hyperplasia | 2 2 2 1 1 2 |
Hypertrophy | 2 1 2 2 3 2 2|
Necrosis | |
Thrombosis | 1 |
Vacuolization Cytoplasmic | 2 2 1 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 3 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 2 1 1 1 1 1 1 1 2 2 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + M + + + + M + + + M M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + M + + + M + + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + + + M M + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 3 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 4| 7| 6| 6| 6| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 1| 6| 3| 3| 3| 3| 1| 3| 2| 6| 2| 3| 3| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 9| 3|
| 4| 4| 6| 5| 2| 6| 5| 4| 1| 4| 5| 5| 5| 5| 5| 7| 5| 6| 2| 4| 5| 4| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 2 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | |
Gliosis | 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 1 1 2 1 1 1 4 3|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X |
Inflammation, Suppurative | 1 1 2 1 2 2 |
Thrombosis | |
Olfactory Epithelium, Atrophy | 2 |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 2 |
Degeneration | |
Hemorrhage | |
Retina, Atrophy | 4 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 2 2 2 3 1 2 1 2 1 1 2 2 3 2 1 2 2 2 3 3 2 1 2|
Renal Tubule, Necrosis | |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 1| 7| 7| 7| 7| 6| 4| 7| 7| 4| |
DAY ON TEST | 5| 3| 3| 8| 3| 3| 1| 3| 2| 3| 3| 0| 9| 3| 5| 1| 1| 3| 3| 3| 8| 6| 3| 3| 9| |
| 2| 6| 6| 1| 6| 5| 3| 5| 7| 4| 4| 9| 4| 0| 3| 4| 3| 5| 6| 5| 1| 4| 4| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + I + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 2 | 4 1.8|
Basophilic Focus | X X X X X X X X X X X X X | 33 |
Clear Cell Focus | X X X X X | 11 |
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | X | 4 |
Fatty Change | 2 2 2 3 1 2 2 2| 9 2.0|
Fibrosis | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X| 6 |
Inflammation, Granulomatous | | 1 2.0|
Mixed Cell Focus | X X | 5 |
Necrosis | | 1 1.0|
Regeneration | 2| 3 2.7|
Bile Duct, Hyperplasia | 2 2 1 2 1 2| 10 1.6|
Centrilobular, Necrosis | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 11 |
Fat, Necrosis | 2 3 2 2 2 | 11 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 1 2 1 2 3 1 2 1 2 2 1| 20 1.7|
Basophilic Focus | X | 3 |
Metaplasia, Hepatocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 4 2 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 4 2 3 3| 6 2.7|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 3 2 2 2 2 1 1 2 2 2 1 2 1 1 1 | 37 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 1| 7| 7| 7| 7| 6| 4| 7| 7| 4| |
DAY ON TEST | 5| 3| 3| 8| 3| 3| 1| 3| 2| 3| 3| 0| 9| 3| 5| 1| 1| 3| 3| 3| 8| 6| 3| 3| 9| |
| 2| 6| 6| 1| 6| 5| 3| 5| 7| 4| 4| 9| 4| 0| 3| 4| 3| 5| 6| 5| 1| 4| 4| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Degeneration, Cystic | 2 2 2| 3 2.0|
Hyperplasia | 2 2 2 2 2 2 2 | 13 1.8|
Hypertrophy | 2 2 2 2 2 2 3 | 14 2.1|
Necrosis | 3| 1 3.0|
Thrombosis | | 1 1.0|
Vacuolization Cytoplasmic | 2 | 6 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 2 1 | 9 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + M M + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 3 2 3 2 2 3 1| 12 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 2 1 1 1 4 2 1 1 2 3 1 2 1 1 1 2 1 2 3 1| 40 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 1 3| 6 2.0|
Inflammation, Granulomatous | 3 | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + + + + M + + + + + + M + M + M M M M + +| 35 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 1| 7| 7| 7| 7| 6| 4| 7| 7| 4| |
DAY ON TEST | 5| 3| 3| 8| 3| 3| 1| 3| 2| 3| 3| 0| 9| 3| 5| 1| 1| 3| 3| 3| 8| 6| 3| 3| 9| |
| 2| 6| 6| 1| 6| 5| 3| 5| 7| 4| 4| 9| 4| 0| 3| 4| 3| 5| 6| 5| 1| 4| 4| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + M + + M + M + + + + +| 44 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 | 4 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis | 2| 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + + + M + M + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 2 3 2 2| 8 2.6|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Focal | 2| 1 2.0|
Gliosis | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 4 1 1 1 | 19 1.5|
Alveolar Epithelium, Hyperplasia | 1 2 1 | 8 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 4 |
Inflammation, Suppurative | 2 1 2 2 2 2 | 12 1.7|
Thrombosis | 3 | 1 3.0|
Olfactory Epithelium, Atrophy | 2 | 2 2.0|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Respiratory Epithelium, Hyperplasia | | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 1| 7| 7| 7| 7| 6| 4| 7| 7| 4| |
DAY ON TEST | 5| 3| 3| 8| 3| 3| 1| 3| 2| 3| 3| 0| 9| 3| 5| 1| 1| 3| 3| 3| 8| 6| 3| 3| 9| |
| 2| 6| 6| 1| 6| 5| 3| 5| 7| 4| 4| 9| 4| 0| 3| 4| 3| 5| 6| 5| 1| 4| 4| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 6 |
Cataract | 2 2 | 4 2.5|
Degeneration | 3 | 1 3.0|
Hemorrhage | 3 | 1 3.0|
Retina, Atrophy | 3 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Nephropathy | 2 2 2 3 2 2 2 2 3 2 3 2 1 2 4 3 2 2 2 1 1 2 2 2| 47 2.0|
Renal Tubule, Necrosis | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 3| 4| 7| 7| 7| 6| 5| 6| 7| 7| 2| 7| 7| 6| 7| 4| 4| 5| 6| 4| 7| 5| 7| 5|
DAY ON TEST | 5| 4| 5| 3| 3| 3| 7| 1| 5| 3| 2| 3| 3| 0| 0| 2| 6| 8| 9| 8| 4| 3| 4| 3| 3|
| 2| 2| 4| 3| 3| 4| 2| 8| 2| 3| 3| 5| 3| 4| 0| 8| 8| 2| 2| 6| 0| 3| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X|
Clear Cell Focus | X X |
Degeneration, Cystic | 2 2 1 4 |
Eosinophilic Focus | X |
Fatty Change | 2 2 2 3 1 1 1 2 1 3|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | |
Mineralization | |
Regeneration | |
Bile Duct, Hyperplasia | 2 2 2 2 1 1 3 2 2 2 1 1 |
Centrilobular, Necrosis | 3 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Hemorrhage | |
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 2 3 2 2 1 3 |
Basophilic Focus | |
Hyperplasia | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Necrosis | 2 3 3 3 2 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 3|
Necrosis | 1 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation | |
Endothelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 3| 4| 7| 7| 7| 6| 5| 6| 7| 7| 2| 7| 7| 6| 7| 4| 4| 5| 6| 4| 7| 5| 7| 5|
DAY ON TEST | 5| 4| 5| 3| 3| 3| 7| 1| 5| 3| 2| 3| 3| 0| 0| 2| 6| 8| 9| 8| 4| 3| 4| 3| 3|
| 2| 2| 4| 3| 3| 4| 2| 8| 2| 3| 3| 5| 3| 4| 0| 8| 8| 2| 2| 6| 0| 3| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 3 2 2 1 1 2 2 1 3 2 3 1 1 2 2 1 2 2|
Artery, Mineralization | |
Atrium, Thrombosis | 4 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 1 2 2 2 2 1 2 1 2 2|
Hypertrophy | 2 2 2 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 2 1 2 2 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 1 2 1 3 1 1 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Inflammation, Chronic Active | 4 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Artery, Inflammation, Chronic Active | 3 3 2 |
Interstitial Cell, Hyperplasia | 2 4 2 2 4 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 3| 4| 7| 7| 7| 6| 5| 6| 7| 7| 2| 7| 7| 6| 7| 4| 4| 5| 6| 4| 7| 5| 7| 5|
DAY ON TEST | 5| 4| 5| 3| 3| 3| 7| 1| 5| 3| 2| 3| 3| 0| 0| 2| 6| 8| 9| 8| 4| 3| 4| 3| 3|
| 2| 2| 4| 3| 3| 4| 2| 8| 2| 3| 3| 5| 3| 4| 0| 8| 8| 2| 2| 6| 0| 3| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 2 1 |
Hematopoietic Cell Proliferation | 2 2 |
Hemorrhage | |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + M + + + + + + M + + + M + + + + + + +|
Galactocele | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 1 2 2 2 4 3 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 1 1 |
Thrombosis | 1 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Metaplasia | 1 |
Olfactory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 3| 4| 7| 7| 7| 6| 5| 6| 7| 7| 2| 7| 7| 6| 7| 4| 4| 5| 6| 4| 7| 5| 7| 5|
DAY ON TEST | 5| 4| 5| 3| 3| 3| 7| 1| 5| 3| 2| 3| 3| 0| 0| 2| 6| 8| 9| 8| 4| 3| 4| 3| 3|
| 2| 2| 4| 3| 3| 4| 2| 8| 2| 3| 3| 5| 3| 4| 0| 8| 8| 2| 2| 6| 0| 3| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Nephropathy | 3 1 1 3 3 3 3 3 3 2 4 1 2 4 2 3 2 2 2 4 2 3 3 3 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 5| 6| 7| 7| 6| |
DAY ON TEST | 5| 7| 3| 5| 9| 3| 3| 3| 3| 2| 5| 9| 3| 3| 6| 2| 3| 3| 0| 2| 0| 7| 3| 3| 6| |
| 5| 5| 3| 9| 7| 4| 3| 3| 4| 1| 1| 4| 4| 4| 4| 3| 4| 3| 4| 4| 2| 1| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + A + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | 2 | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A + + + + + + + A + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + + + + + A + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | X X X X X X X | 17 |
Clear Cell Focus | X X X X | 6 |
Degeneration, Cystic | 2 1 2 2 1 | 9 1.9|
Eosinophilic Focus | X | 2 |
Fatty Change | 2 1 1 2 3| 15 1.8|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Mineralization | 2 | 1 2.0|
Regeneration | 2 2 | 2 2.0|
Bile Duct, Hyperplasia | 1 1 2 3 2 3 1 2 3 1 1 1 2 | 25 1.8|
Centrilobular, Necrosis | 2 1 2 4 1 | 7 2.1|
__________________________________________________________________________|____________|
Mesentery | + + + + +| 8 |
Fat, Hemorrhage | 2| 1 2.0|
Fat, Necrosis | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 2 3 2 2 2 3 1 | 18 2.1|
Basophilic Focus | X | 1 |
Hyperplasia | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 1.0|
Necrosis | 3 1 2 4 1 4 3| 14 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1| 5 1.4|
Necrosis | 1 2 2 3| 6 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 5| 6| 7| 7| 6| |
DAY ON TEST | 5| 7| 3| 5| 9| 3| 3| 3| 3| 2| 5| 9| 3| 3| 6| 2| 3| 3| 0| 2| 0| 7| 3| 3| 6| |
| 5| 5| 3| 9| 7| 4| 3| 3| 4| 1| 1| 4| 4| 4| 4| 3| 4| 3| 4| 4| 2| 1| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Inflammation | 3 | 1 3.0|
Endothelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 3 3 1 2 3 2 2 1 2 2 3 2 2 2 2 1 2 2 3| 41 1.9|
Artery, Mineralization | 1 | 1 1.0|
Atrium, Thrombosis | 4 4 | 4 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Hyperplasia | 2 2 2 2 2 3 3 2 2 2 2 2 | 23 2.0|
Hypertrophy | 2 2 2 2 | 8 2.0|
Vacuolization Cytoplasmic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 3 2 2 2 3 2 1 2 | 19 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Hyperplasia | 3 2 1| 5 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 1 | 5 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 2 2 1 2 2 1 1 1 2 1 1 1| 30 1.3|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 2 |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 3 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 2 2 2 2 2 | 11 1.9|
Inflammation, Chronic Active | 4 2 2 | 5 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 5| 6| 7| 7| 6| |
DAY ON TEST | 5| 7| 3| 5| 9| 3| 3| 3| 3| 2| 5| 9| 3| 3| 6| 2| 3| 3| 0| 2| 0| 7| 3| 3| 6| |
| 5| 5| 3| 9| 7| 4| 3| 3| 4| 1| 1| 4| 4| 4| 4| 3| 4| 3| 4| 4| 2| 1| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + A + + + + + + + A + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Artery, Inflammation, Chronic Active | 3 3 2| 6 2.7|
Interstitial Cell, Hyperplasia | 2 2 2 4 2 2 2 3| 15 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
Iliac, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + M M M + + +| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + + + + + M + + + + + + + + + M + + +| 46 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 2 2 3 2 2 | 11 1.9|
Hematopoietic Cell Proliferation | 3 | 3 2.3|
Hemorrhage | 2 | 1 2.0|
Necrosis | 4 2 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M M +| 47 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + M + + + + + + + + M + + + +| 42 |
Galactocele | 3 | 2 3.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 5| 6| 7| 7| 6| |
DAY ON TEST | 5| 7| 3| 5| 9| 3| 3| 3| 3| 2| 5| 9| 3| 3| 6| 2| 3| 3| 0| 2| 0| 7| 3| 3| 6| |
| 5| 5| 3| 9| 7| 4| 3| 3| 4| 1| 1| 4| 4| 4| 4| 3| 4| 3| 4| 4| 2| 1| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 2 3 1 1 1 1 1 1 2 1 | 21 1.6|
Alveolar Epithelium, Hyperplasia | 2 1 1| 7 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X X| 4 |
Inflammation, Suppurative | 1 1 2 1 2 2 1 1 3| 11 1.5|
Thrombosis | 3 | 2 2.0|
Olfactory Epithelium, Atrophy | 1| 1 1.0|
Olfactory Epithelium, Metaplasia | 2 1 2 2 2 2| 7 1.7|
Olfactory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
Retina, Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3| 2 3.5|
Infarct | 3 | 1 3.0|
Nephropathy | 3 2 4 3 2 3 3 3 3 3 3 2 3 4 2 3 3 3 2 3 2 2 3 4 4| 50 2.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 7| 7| 7| 7| 3| 5| 7| 5| 6| 7| 6| 5|
DAY ON TEST | 3| 3| 5| 1| 9| 3| 3| 0| 9| 3| 2| 5| 9| 1| 3| 3| 3| 9| 1| 0| 4| 9| 3| 0| 3|
| 3| 8| 9| 4| 2| 4| 3| 4| 8| 4| 3| 7| 7| 9| 3| 3| 4| 8| 0| 2| 9| 3| 3| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
220 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Clear Cell Focus | X X X X X |
Degeneration, Cystic | 2 1 2 |
Eosinophilic Focus | X |
Fatty Change | 1 2 1 2 3 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | 1 |
Necrosis | |
Bile Duct, Hyperplasia | 2 2 2 1 1 2 2 1 1 1 2 2 2 2 2 |
Centrilobular, Necrosis | 2 1 2 2 2 1 2|
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Hemorrhage | |
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Hyperplasia, Squamous | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 1 2 1 2 1 2 2 1 |
Basophilic Focus | X X |
Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Necrosis | 2 3 3 2 3 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | 3 2 2 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 1 3 2 2 2 2 1 2 2 2 2 3 2 2 2 2 2 1 2 2|
Atrium, Thrombosis | 1 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 7| 7| 7| 7| 3| 5| 7| 5| 6| 7| 6| 5|
DAY ON TEST | 3| 3| 5| 1| 9| 3| 3| 0| 9| 3| 2| 5| 9| 1| 3| 3| 3| 9| 1| 0| 4| 9| 3| 0| 3|
| 3| 8| 9| 4| 2| 4| 3| 4| 8| 4| 3| 7| 7| 9| 3| 3| 4| 8| 0| 2| 9| 3| 3| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
220 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 2 2 2 2 1 2 1 2 |
Hypertrophy | 2 2 2 |
Vacuolization Cytoplasmic | 2 3 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 3 3 1 2 3 1 2 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | |
Hyperplasia | 2 2 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 1 1 1 1 3 1 1 1 1 1 1 1 1 3 2 1|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 2 1 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Artery, Inflammation, Chronic Active | |
Interstitial Cell, Hyperplasia | 3 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 |
__________________________________________________________________________|
Lymph Node | + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M M + M + + + M + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + M + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 4 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 7| 7| 7| 7| 3| 5| 7| 5| 6| 7| 6| 5|
DAY ON TEST | 3| 3| 5| 1| 9| 3| 3| 0| 9| 3| 2| 5| 9| 1| 3| 3| 3| 9| 1| 0| 4| 9| 3| 0| 3|
| 3| 8| 9| 4| 2| 4| 3| 4| 8| 4| 3| 7| 7| 9| 3| 3| 4| 8| 0| 2| 9| 3| 3| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
220 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 2 1 3 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | M + M + + + M + + + + M + + + + + M + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + M + + + + + + M + M + + + + + +|
Galactocele | 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
Hyperostosis | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 4 |
Inflammation, Chronic Active | 1 2 1 1 1 4|
Thrombosis | 3|
Alveolar Epithelium, Hyperplasia | 2 4 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X|
Inflammation, Suppurative | 1 1 2 2 1 1|
Thrombosis | 3 4|
Olfactory Epithelium, Metaplasia | 2 2 |
Respiratory Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Cornea, Inflammation, Chronic Active | |
Retina, Atrophy | 3 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 7| 7| 7| 7| 3| 5| 7| 5| 6| 7| 6| 5|
DAY ON TEST | 3| 3| 5| 1| 9| 3| 3| 0| 9| 3| 2| 5| 9| 1| 3| 3| 3| 9| 1| 0| 4| 9| 3| 0| 3|
| 3| 8| 9| 4| 2| 4| 3| 4| 8| 4| 3| 7| 7| 9| 3| 3| 4| 8| 0| 2| 9| 3| 3| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
220 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4 |
Nephropathy | 4 2 3 3 2 3 2 3 2 3 4 4 2 4 3 2 3 1 3 2 2 4 3 2 2|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 4| 6| 5| 6| 7| 4| 6| 6| 7| 7| 6| |
DAY ON TEST | 5| 3| 3| 1| 8| 8| 2| 3| 3| 3| 3| 3| 5| 6| 9| 5| 8| 7| 3| 5| 2| 7| 0| 0| 3| |
| 7| 4| 3| 7| 8| 2| 0| 3| 3| 3| 3| 3| 7| 4| 9| 2| 1| 1| 3| 5| 9| 0| 2| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
220 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + I| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + A + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X | 13 |
Clear Cell Focus | X X X X | 9 |
Degeneration, Cystic | 2 3 2 2 2 2 | 9 2.0|
Eosinophilic Focus | X X X | 4 |
Fatty Change | 1 1 1 2 1 1 1 | 12 1.4|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Granulomatous | | 1 1.0|
Necrosis | 1 | 1 1.0|
Bile Duct, Hyperplasia | 2 2 2 2 1 1 2 1 1 1 2 2 1 1 2 1 2| 32 1.6|
Centrilobular, Necrosis | 1 2 2 1 | 11 1.6|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 12 |
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Necrosis | 2 2 3 2 2 2 3| 10 2.2|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Pharyngeal, Hyperplasia, Squamous | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 2 2 2 1 2 1 2 2 2 3| 23 1.7|
Basophilic Focus | X X | 4 |
Hyperplasia | 2 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 1 3.0|
Necrosis | 4 4 | 8 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 4| 6| 5| 6| 7| 4| 6| 6| 7| 7| 6| |
DAY ON TEST | 5| 3| 3| 1| 8| 8| 2| 3| 3| 3| 3| 3| 5| 6| 9| 5| 8| 7| 3| 5| 2| 7| 0| 0| 3| |
| 7| 4| 3| 7| 8| 2| 0| 3| 3| 3| 3| 3| 7| 4| 9| 2| 1| 1| 3| 5| 9| 0| 2| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
220 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 2 2 1 2 3 2 2 3 2 2 2 2 2 1 2 2 2 | 44 1.9|
Atrium, Thrombosis | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 1 1 1 3 2 2 2 2 | 23 1.8|
Hypertrophy | 2 1 1 2 2 2 2 2| 11 1.8|
Vacuolization Cytoplasmic | 2 2| 6 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Hyperplasia | 2 2 3 2 2 2 2 2 1 3 | 19 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + M + + M + + +| 46 |
Cyst | 3 | 1 3.0|
Hyperplasia | 3 2 | 6 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 3 2 3 | 6 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 3 1 1 1 1 1 2 1 1 2 | 30 1.4|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + +| 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 3 3 3 3 | 13 2.2|
Inflammation, Chronic Active | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Artery, Inflammation, Chronic Active | 3 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 4| 6| 5| 6| 7| 4| 6| 6| 7| 7| 6| |
DAY ON TEST | 5| 3| 3| 1| 8| 8| 2| 3| 3| 3| 3| 3| 5| 6| 9| 5| 8| 7| 3| 5| 2| 7| 0| 0| 3| |
| 7| 4| 3| 7| 8| 2| 0| 3| 3| 3| 3| 3| 7| 4| 9| 2| 1| 1| 3| 5| 9| 0| 2| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
220 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 3 2 4 1 2 2 3 | 13 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Histiocytic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M M M M + + M M +| 39 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + M + +| 46 |
Infiltration Cellular, Plasma Cell | | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + M M + + M + + + + + + M + + + + + + +| 44 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 2 2 2 2 1 2| 14 1.9|
Hematopoietic Cell Proliferation | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + I + + + + + M + + + + + + + + + M + + + + + + +| 43 |
Galactocele | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 2.0|
Hyperostosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 4.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 | 16 1.3|
Thrombosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 | 11 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 4| 6| 5| 6| 7| 4| 6| 6| 7| 7| 6| |
DAY ON TEST | 5| 3| 3| 1| 8| 8| 2| 3| 3| 3| 3| 3| 5| 6| 9| 5| 8| 7| 3| 5| 2| 7| 0| 0| 3| |
| 7| 4| 3| 7| 8| 2| 0| 3| 3| 3| 3| 3| 7| 4| 9| 2| 1| 1| 3| 5| 9| 0| 2| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
220 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | X | 4 |
Inflammation, Suppurative | 3 2 1 | 9 1.6|
Thrombosis | 1 2 | 4 2.5|
Olfactory Epithelium, Metaplasia | | 2 2.0|
Respiratory Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | | 1 3.0|
Cornea, Inflammation, Chronic Active | 3 | 1 3.0|
Retina, Atrophy | | 2 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 4.0|
Nephropathy | 3 3 3 3 2 3 1 3 4 4 4 2 3 3 2 2 2 4 2 2 2 3 4 3 2| 50 2.7|
Renal Tubule, Hyperplasia | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 4| 5| 4| 5| 5| 7|
DAY ON TEST | 5| 7| 3| 1| 6| 3| 4| 6| 9| 3| 8| 6| 2| 3| 3| 2| 7| 9| 3| 6| 2| 5| 1| 1| 0|
| 5| 6| 3| 2| 4| 4| 7| 7| 2| 4| 6| 6| 2| 4| 4| 7| 1| 1| 3| 9| 1| 4| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
700 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + A + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + A + + + + A + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + A + + + A + + + + A + + + + + + +|
Diverticulum | |
Mineralization | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + A + + + + + + +|
Inflammation, Acute | |
Necrosis | 1|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + A + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + A + + + + A + + + + + + +|
Inflammation, Chronic Active | |
Necrosis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X|
Clear Cell Focus | X X X |
Degeneration, Cystic | 2 2 4 1 2 2|
Eosinophilic Focus | X X |
Fatty Change | 2 1 1 3 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Acute | |
Necrosis | |
Regeneration | 2 4 |
Bile Duct, Hyperplasia | 2 1 2 3 2 2 1 2 2 2 3 2 1 2 1 1|
Centrilobular, Necrosis | 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Thrombosis | 4 |
Artery, Mineralization | 4 |
Fat, Hemorrhage | |
Fat, Inflammation, Chronic Active | 2 |
Fat, Necrosis | 2 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 2 2 2 2 2 2|
Basophilic Focus | |
Hyperplasia | 2 2 3 4 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 |
Inflammation, Acute | |
Mineralization | 3 |
Necrosis | 2 3 4 3 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 4| 5| 4| 5| 5| 7|
DAY ON TEST | 5| 7| 3| 1| 6| 3| 4| 6| 9| 3| 8| 6| 2| 3| 3| 2| 7| 9| 3| 6| 2| 5| 1| 1| 0|
| 5| 6| 3| 2| 4| 4| 7| 7| 2| 4| 6| 6| 2| 4| 4| 7| 1| 1| 3| 9| 1| 4| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
700 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 1 4 |
Necrosis | 3 3 3 |
__________________________________________________________________________|
Tongue | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 2 3 2 2 2 2 3 2 3 2 2 2 2 2 3 1 2 2 1|
Artery, Mineralization | 3 |
Atrium, Thrombosis | 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 1 2|
Hypertrophy | 4 2 1 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 4 2 2 2 2 2 1 2 2|
Bilateral, Hyperplasia | 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 2 4 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + A + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 3 1 1 2 1 1 1 1 1 2 3 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 3 3 1 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + A + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 4| 5| 4| 5| 5| 7|
DAY ON TEST | 5| 7| 3| 1| 6| 3| 4| 6| 9| 3| 8| 6| 2| 3| 3| 2| 7| 9| 3| 6| 2| 5| 1| 1| 0|
| 5| 6| 3| 2| 4| 4| 7| 7| 2| 4| 6| 6| 2| 4| 4| 7| 1| 1| 3| 9| 1| 4| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
700 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | |
Artery, Inflammation, Chronic Active | 3 |
Interstitial Cell, Hyperplasia | 2 1 2 3 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + + + + + + + + M M + + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + M + + + + + + M + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 4 3 2 3 2 2 1 2|
Hematopoietic Cell Proliferation | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + M + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3 |
Hyperostosis | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 1 1 3 2 3 1|
Mineralization | 4 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Artery, Mediastinum, Mineralization | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + A + + + + + + +|
Foreign Body | X X |
Inflammation, Suppurative | 2 2 2 |
Thrombosis | 3 4 2 2 |
Olfactory Epithelium, Atrophy | 1 2 2 |
Olfactory Epithelium, Metaplasia | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 4| 5| 4| 5| 5| 7|
DAY ON TEST | 5| 7| 3| 1| 6| 3| 4| 6| 9| 3| 8| 6| 2| 3| 3| 2| 7| 9| 3| 6| 2| 5| 1| 1| 0|
| 5| 6| 3| 2| 4| 4| 7| 7| 2| 4| 6| 6| 2| 4| 4| 7| 1| 1| 3| 9| 1| 4| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
700 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 3 |
Hemorrhage | |
Cornea, Inflammation, Chronic Active | |
Retina, Atrophy | 4 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
Infarct | |
Mineralization | 3 |
Nephropathy | 4 2 3 3 2 3 2 4 2 4 3 4 2 3 3 4 3 2 3 2 2 2 2 3 4|
Renal Tubule, Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 6| 7| 5| 5| 7| 7| 5| 5| 4| 6| 6| 7| 7| 7| 6| 5| 5| 7| 6| |
DAY ON TEST | 6| 6| 3| 3| 8| 2| 8| 3| 8| 3| 3| 3| 4| 6| 5| 2| 9| 3| 3| 3| 8| 5| 9| 3| 7| |
| 7| 8| 3| 3| 3| 8| 1| 3| 0| 7| 3| 3| 1| 6| 4| 1| 5| 3| 3| 3| 4| 5| 4| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
700 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + I + + + + + + + + + +| 46 |
Inflammation, Acute | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Diverticulum | X | 1 |
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute | 3 | 1 3.0|
Necrosis | 2 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 1 2 | 5 1.6|
Basophilic Focus | X X X X X X | 13 |
Clear Cell Focus | X X X X | 7 |
Degeneration, Cystic | 1 1 3 1 2 2 2 2| 14 1.9|
Eosinophilic Focus | X | 3 |
Fatty Change | 2 2 3 1 1| 9 1.8|
Hepatodiaphragmatic Nodule | X X | 4 |
Inflammation, Acute | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
Regeneration | | 2 3.0|
Bile Duct, Hyperplasia | 2 1 3 1 1 1 1 2 2 1 1 2 2 2 2 1 1 1 3 3 | 36 1.7|
Centrilobular, Necrosis | 1 1 1 1 1 | 10 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + | 11 |
Thrombosis | | 1 4.0|
Artery, Mineralization | | 1 4.0|
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 2 2 2 2 1 1 2 1 2 2 2 2 | 23 1.8|
Basophilic Focus | X | 1 |
Hyperplasia | 3 2 2 3 | 9 2.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 6| 7| 5| 5| 7| 7| 5| 5| 4| 6| 6| 7| 7| 7| 6| 5| 5| 7| 6| |
DAY ON TEST | 6| 6| 3| 3| 8| 2| 8| 3| 8| 3| 3| 3| 4| 6| 5| 2| 9| 3| 3| 3| 8| 5| 9| 3| 7| |
| 7| 8| 3| 3| 3| 8| 1| 3| 0| 7| 3| 3| 1| 6| 4| 1| 5| 3| 3| 3| 4| 5| 4| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
700 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | | 1 1.0|
Inflammation, Acute | 2 | 1 2.0|
Mineralization | 2 | 2 2.5|
Necrosis | 4 2 2 3| 10 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 3 | 4 3.0|
Necrosis | 2 2 2 2 | 7 2.4|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Aorta, Mineralization | 4 | 2 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 3 2 2 3 3 2 1 2 2 3 2 3 2 2 2 | 44 2.2|
Artery, Mineralization | 4 | 2 3.5|
Atrium, Thrombosis | 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 2 1 2 3 2 | 19 1.9|
Hypertrophy | 2 | 4 2.3|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 2 | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 2 2 2 2 2 3 3 2 2 3 3| 25 2.3|
Bilateral, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + + + + + M + + + + + + + + + + + +| 45 |
Hyperplasia | 2 2 4 3 | 8 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 3 1 3 3 3 3 | 9 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 2 1 1 1 1 1 2 1 2 3 1 2 2| 30 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 6| 7| 5| 5| 7| 7| 5| 5| 4| 6| 6| 7| 7| 7| 6| 5| 5| 7| 6| |
DAY ON TEST | 6| 6| 3| 3| 8| 2| 8| 3| 8| 3| 3| 3| 4| 6| 5| 2| 9| 3| 3| 3| 8| 5| 9| 3| 7| |
| 7| 8| 3| 3| 3| 8| 1| 3| 0| 7| 3| 3| 1| 6| 4| 1| 5| 3| 3| 3| 4| 5| 4| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
700 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 2 2 2 4 2 | 15 2.3|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
Interstitial Cell, Hyperplasia | 3 | 8 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + M + + + + + M + + + M| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + M + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + M + + + + + + + M| 45 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 2 2 2 2 2 1 2 2 2 2 2 2 2 | 24 2.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Necrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Galactocele | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 3 2 2| 6 2.2|
Hyperostosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 6| 7| 5| 5| 7| 7| 5| 5| 4| 6| 6| 7| 7| 7| 6| 5| 5| 7| 6| |
DAY ON TEST | 6| 6| 3| 3| 8| 2| 8| 3| 8| 3| 3| 3| 4| 6| 5| 2| 9| 3| 3| 3| 8| 5| 9| 3| 7| |
| 7| 8| 3| 3| 3| 8| 1| 3| 0| 7| 3| 3| 1| 6| 4| 1| 5| 3| 3| 3| 4| 5| 4| 3| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
700 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 2 1 1 1 1 1 4 1 1 1 2 | 22 1.5|
Mineralization | 3 | 2 3.5|
Alveolar Epithelium, Hyperplasia | 1 1 | 4 1.0|
Artery, Mediastinum, Mineralization | 4 | 2 3.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X | 3 |
Inflammation, Suppurative | 1 2 1 2 2 2 1| 10 1.7|
Thrombosis | 1 3 2 1 4 3 | 10 2.5|
Olfactory Epithelium, Atrophy | 2 2 2 2 2| 8 1.9|
Olfactory Epithelium, Metaplasia | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 1 | 2 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | 3 | 3 3.0|
Hemorrhage | 3 | 1 3.0|
Cornea, Inflammation, Chronic Active | 2 | 1 2.0|
Retina, Atrophy | 3 | 3 3.3|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 | 4 2.3|
Infarct | 2 3 | 2 2.5|
Mineralization | 4 | 2 3.5|
Nephropathy | 2 4 3 3 3 4 4 4 2 2 4 3 2 4 1 3 4 3 4 3 3 2 2 3 4| 50 2.9|
Renal Tubule, Hyperplasia | 2 3 2 | 6 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 0| 7| 7| 6| 6| 7| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 2| 5| 7| 7|
DAY ON TEST | 8| 2| 7| 3| 2| 3| 3| 2| 6| 3| 8| 8| 3| 3| 2| 2| 1| 8| 0| 3| 2| 2| 6| 3| 3|
| 8| 1| 8| 3| 6| 3| 4| 2| 4| 4| 5| 8| 3| 4| 7| 3| 8| 1| 9| 3| 1| 2| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Necrosis | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | X X X X X X X X|
Clear Cell Focus | X X X|
Degeneration, Cystic | 2 2 3 4 2 2 2|
Eosinophilic Focus | X X |
Fatty Change | 2 3 2 2 2 3 2 |
Hematopoietic Cell Proliferation | 3 |
Hepatodiaphragmatic Nodule | X X |
Infarct | 4 |
Mixed Cell Focus | |
Necrosis | 2 |
Regeneration | 4 2 3 |
Artery, Inflammation, Chronic Active | 4 |
Bile Duct, Hyperplasia | 2 2 2 2 1 3 2 2 2 2 2 4 1 4 |
Centrilobular, Necrosis | 2 3 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + |
Artery, Mineralization | |
Fat, Hemorrhage | |
Fat, Inflammation, Chronic Active | 2 |
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 2 1 2 2 2 2 |
Basophilic Focus | X X |
Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Squamous | |
Necrosis | 3 2 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | 1 2 1 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 0| 7| 7| 6| 6| 7| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 2| 5| 7| 7|
DAY ON TEST | 8| 2| 7| 3| 2| 3| 3| 2| 6| 3| 8| 8| 3| 3| 2| 2| 1| 8| 0| 3| 2| 2| 6| 3| 3|
| 8| 1| 8| 3| 6| 3| 4| 2| 4| 4| 5| 8| 3| 4| 7| 3| 8| 1| 9| 3| 1| 2| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 3 2 3 2 2 2 3 1 2 2 2 2 2 2 2|
Artery, Mineralization | |
Atrium, Thrombosis | 2 4 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Degeneration, Cystic | |
Hyperplasia | 2 2 1 2 1 2 2 2 2 2 2 2 |
Hypertrophy | |
Thrombosis | 2 |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 2 2 2 2 1 2 2 |
Thrombosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 3 4 1 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Hyperplasia | 2 4 3 2 3 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 1 2 1 2 1 2 1 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + M |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 2 4 2 2 2 2 1 |
Inflammation, Chronic Active | 3 2 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 0| 7| 7| 6| 6| 7| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 2| 5| 7| 7|
DAY ON TEST | 8| 2| 7| 3| 2| 3| 3| 2| 6| 3| 8| 8| 3| 3| 2| 2| 1| 8| 0| 3| 2| 2| 6| 3| 3|
| 8| 1| 8| 3| 6| 3| 4| 2| 4| 4| 5| 8| 3| 4| 7| 3| 8| 1| 9| 3| 1| 2| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myelofibrosis | |
Necrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + M M + M + M + + M M + + M + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + M + + + M + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + M + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Fibrosis | 3 2 3 2 3 2 2 3 1 3 2|
Hematopoietic Cell Proliferation | 3 3 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + M + + M + + + + + + + + +|
Galactocele | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
Hyperostosis | 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 2 1|
Mineralization | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 1 1 2 1 |
Artery, Mediastinum, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Suppurative | 2 2 1 1 2 |
Thrombosis | 4 3 1 |
Olfactory Epithelium, Atrophy | 2 2 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 0| 7| 7| 6| 6| 7| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 2| 5| 7| 7|
DAY ON TEST | 8| 2| 7| 3| 2| 3| 3| 2| 6| 3| 8| 8| 3| 3| 2| 2| 1| 8| 0| 3| 2| 2| 6| 3| 3|
| 8| 1| 8| 3| 6| 3| 4| 2| 4| 4| 5| 8| 3| 4| 7| 3| 8| 1| 9| 3| 1| 2| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Mineralization | |
Nephropathy | 2 4 2 3 4 4 3 3 3 3 2 3 2 3 3 3 4 4 4 3 2 2 3 4|
Renal Tubule, Hyperplasia | 4 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 3| 7| 7| 6| 6| 7| 5| 7| 5| 6| 7| 5| 6| 6| 7| 7| 5| 6| 7| 5| 6| 6| |
DAY ON TEST | 3| 1| 1| 6| 0| 3| 3| 8| 3| 4| 3| 8| 6| 3| 1| 8| 6| 2| 3| 8| 6| 2| 6| 6| 9| |
| 3| 2| 1| 1| 8| 3| 0| 6| 3| 8| 3| 1| 8| 4| 7| 0| 7| 7| 3| 1| 7| 1| 0| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | 2 | 1 2.0|
Necrosis | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 3 1.7|
Basophilic Focus | X X X X X X X X | 16 |
Clear Cell Focus | X X X X X | 8 |
Degeneration, Cystic | 1 3 1 2 2 2 1 2 1 1| 17 1.9|
Eosinophilic Focus | X | 3 |
Fatty Change | 1 1 1 2| 11 1.9|
Hematopoietic Cell Proliferation | | 1 3.0|
Hepatodiaphragmatic Nodule | X X | 4 |
Infarct | | 1 4.0|
Mixed Cell Focus | X | 1 |
Necrosis | | 1 2.0|
Regeneration | 4 2 4 | 6 3.2|
Artery, Inflammation, Chronic Active | | 1 4.0|
Bile Duct, Hyperplasia | 3 3 2 1 1 2 1 2 2 1 1 1 2 1 3 | 29 2.0|
Centrilobular, Necrosis | 2 1 1 3 2 | 9 1.9|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Artery, Mineralization | 1 3 | 2 2.0|
Fat, Hemorrhage | 3 | 1 3.0|
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 2 2 2 1 2| 15 1.9|
Basophilic Focus | X | 3 |
Hyperplasia | 4 2 4 2 | 7 2.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 | 1 4.0|
Hyperplasia, Squamous | 1 | 1 1.0|
Necrosis | 2 2 3 1 3 2 3 3| 12 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 3| 7| 7| 6| 6| 7| 5| 7| 5| 6| 7| 5| 6| 6| 7| 7| 5| 6| 7| 5| 6| 6| |
DAY ON TEST | 3| 1| 1| 6| 0| 3| 3| 8| 3| 4| 3| 8| 6| 3| 1| 8| 6| 2| 3| 8| 6| 2| 6| 6| 9| |
| 3| 2| 1| 1| 8| 3| 0| 6| 3| 8| 3| 1| 8| 4| 7| 0| 7| 7| 3| 1| 7| 1| 0| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 3 4 2 | 4 3.0|
Necrosis | 1 1 1 2 2 2 | 9 1.4|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 3 |
Aorta, Mineralization | 3 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 3 2 1 2 2 2 2 2 2 2 1 2 1 2 1 3 4 2 | 38 2.1|
Artery, Mineralization | 3 3 4 3 | 4 3.3|
Atrium, Thrombosis | 2 2 | 5 2.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Degeneration, Cystic | 3 | 1 3.0|
Hyperplasia | 2 2 2 2 2 2 1 1| 20 1.8|
Hypertrophy | 4 2 2 2 | 4 2.5|
Thrombosis | | 1 2.0|
Vacuolization Cytoplasmic | 3 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 1 1 3 3 3 4 2 3 | 21 2.2|
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + I + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
Hyperplasia | 4 2 1 3 2 3 3 4 2 | 13 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 3 3 2 2 3 3 | 11 2.7|
Pars Intermedia, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 3 1 2 1 1 1 3 2 1 1 2 1 1 1 1 3 1| 34 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 3| 7| 7| 6| 6| 7| 5| 7| 5| 6| 7| 5| 6| 6| 7| 7| 5| 6| 7| 5| 6| 6| |
DAY ON TEST | 3| 1| 1| 6| 0| 3| 3| 8| 3| 4| 3| 8| 6| 3| 1| 8| 6| 2| 3| 8| 6| 2| 6| 6| 9| |
| 3| 2| 1| 1| 8| 3| 0| 6| 3| 8| 3| 1| 8| 4| 7| 0| 7| 7| 3| 1| 7| 1| 0| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | 2 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 1 2 2 1 2| 17 2.1|
Inflammation, Chronic Active | 4 2 | 6 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 | 1 2.0|
Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 9 |
Renal, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + M + M M + M + + + + M + + + + + + +| 35 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + M| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + M + + + + + + + + + + + + + + + + + M +| 44 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 3| 1 3.0|
Fibrosis | 1 3 3 3 3 2 1 2 2 2 2 | 22 2.3|
Hematopoietic Cell Proliferation | 2 4 3 | 5 3.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + M +| 47 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + M + + + + M + + + + + + + +| 44 |
Galactocele | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 2 2 4 2 | 7 2.1|
Hyperostosis | | 2 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05135-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOPRENE Date: 09/24/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:01:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 3| 7| 7| 6| 6| 7| 5| 7| 5| 6| 7| 5| 6| 6| 7| 7| 5| 6| 7| 5| 6| 6| |
DAY ON TEST | 3| 1| 1| 6| 0| 3| 3| 8| 3| 4| 3| 8| 6| 3| 1| 8| 6| 2| 3| 8| 6| 2| 6| 6| 9| |
| 3| 2| 1| 1| 8| 3| 0| 6| 3| 8| 3| 1| 8| 4| 7| 0| 7| 7| 3| 1| 7| 1| 0| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1| 15 1.1|
Mineralization | 2 4 | 2 3.0|
Thrombosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 4 1 1 2 | 10 1.6|
Artery, Mediastinum, Mineralization | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 2 |
Inflammation, Suppurative | 2 1 2 1 | 9 1.6|
Thrombosis | 2 4 | 5 2.8|
Olfactory Epithelium, Atrophy | | 2 2.0|
Olfactory Epithelium, Metaplasia | 1 | 2 1.5|
Respiratory Epithelium, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 3 | 2 3.0|
Retina, Atrophy | 3 | 2 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 2 3.0|
Mineralization | 2 2 3 | 3 2.3|
Nephropathy | 4 2 4 1 4 4 4 3 4 4 3 2 3 4 2 4 3 4 3 2 4 4 2 4 4| 49 3.2|
Renal Tubule, Hyperplasia | 2 3 4 2 4 4 | 8 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
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---------- END OF REPORT ----------
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