TDMS Study 05136-08 Pathology Tables
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 0000126-99-8
Lock Date: 04/14/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 13 27 38 41
Natural Death 2 6 11 5
Accidently Killed 1 1
Survivors
Terminal Sacrifice 35 16 1 2
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (48) (50) (50)
Epithelium, Hyperplasia 1 (2%)
Gallbladder (45) (44) (42) (42)
Angiectasis 1 (2%)
Cyst 1 (2%)
Degeneration, Hyaline 2 (5%)
Inflammation, Suppurative 3 (7%) 1 (2%) 2 (5%) 2 (5%)
Necrosis 1 (2%)
Intestine Large, Colon (50) (47) (48) (49)
Inflammation, Suppurative 1 (2%)
Intestine Large, Cecum (50) (45) (45) (49)
Hemorrhage 1 (2%)
Lymphoid Tissue, Hyperplasia 1 (2%) 1 (2%)
Intestine Small, Duodenum (49) (45) (42) (48)
Necrosis 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Jejunum (50) (46) (44) (49)
Epithelium, Hyperplasia 1 (2%)
Peyer's Patch, Hyperplasia 1 (2%) 1 (2%)
Liver (50) (49) (50) (50)
Angiectasis 2 (4%) 3 (6%) 4 (8%) 1 (2%)
Basophilic Focus 4 (8%) 2 (4%)
Clear Cell Focus 1 (2%)
Degeneration, Fatty 1 (2%) 2 (4%)
Eosinophilic Focus 13 (26%) 12 (24%) 15 (30%) 28 (56%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 5 (10%) 9 (18%) 12 (24%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%) 1 (2%)
Necrosis 4 (8%) 5 (10%) 13 (26%) 7 (14%)
Regeneration 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Vacuolization Cytoplasmic 2 (4%) 1 (2%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 2 (4%) 1 (2%) 1 (2%) 3 (6%)
Centrilobular, Degeneration 2 (4%) 3 (6%)
Centrilobular, Necrosis 2 (4%) 2 (4%) 3 (6%)
Mesentery (10) (14) (27) (21)
Angiectasis 1 (10%) 1 (5%)
Hemorrhage 1 (4%)
Fat, Inflammation, Chronic 1 (7%)
Fat, Necrosis 7 (70%) 3 (21%) 2 (7%) 18 (86%)
Oral Mucosa (1)
Pharyngeal, Hyperplasia 1 (100%)
Pancreas (49) (49) (48) (50)
Angiectasis 1 (2%)
Atrophy 3 (6%) 6 (12%) 5 (10%) 3 (6%)
Hyperplasia 1 (2%)
Hypertrophy 2 (4%) 3 (6%) 3 (6%) 4 (8%)
Duct, Cyst 1 (2%)
Salivary Glands (50) (49) (50) (50)
Inflammation 1 (2%)
Stomach, Forestomach (50) (49) (49) (50)
Diverticulum 2 (4%)
Hyperplasia 3 (6%)
Inflammation, Suppurative 2 (4%) 8 (16%)
Mineralization 1 (2%)
Ulcer 2 (4%) 3 (6%) 5 (10%)
Epithelium, Hyperplasia 4 (8%) 3 (6%) 8 (16%) 27 (54%)
Stomach, Glandular (50) (48) (49) (50)
Degeneration, Hyaline 1 (2%)
Inflammation, Suppurative 4 (8%)
Necrosis 3 (6%)
Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2)
Hyperplasia 1 (50%)
Inflammation 1 (50%)
Heart (50) (49) (50) (50)
Cardiomyopathy 35 (70%) 35 (71%) 34 (68%) 33 (66%)
Mineralization 1 (2%)
Artery, Inflammation 1 (2%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (48) (49) (50)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 1 (2%)
Hyperplasia 1 (2%)
Hypertrophy 2 (4%) 2 (4%) 3 (6%) 2 (4%)
Inflammation, Focal, Granulomatous 1 (2%)
Necrosis 1 (2%)
Capsule, Hyperplasia 1 (2%)
Adrenal Medulla (50) (48) (48) (50)
Hyperplasia 3 (6%) 2 (4%) 1 (2%)
Necrosis 1 (2%)
Islets, Pancreatic (49) (49) (48) (50)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (49) (48) (48) (50)
Pars Distalis, Angiectasis 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 18 (37%) 8 (17%) 7 (15%) 9 (18%)
Pars Intermedia, Hyperplasia 1 (2%) 1 (2%)
Thyroid Gland (50) (49) (49) (50)
Follicular Cell, Hyperplasia 12 (24%) 15 (31%) 8 (16%) 4 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (47) (47) (49)
Angiectasis 1 (2%)
Atrophy 7 (15%) 8 (17%) 7 (15%) 6 (12%)
Cyst 20 (42%) 18 (38%) 5 (11%) 6 (12%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Corpus Luteum, Hyperplasia 1 (2%)
Granulosa Cell, Hyperplasia 2 (4%) 1 (2%)
Uterus (50) (49) (50) (50)
Angiectasis 3 (6%) 2 (4%) 2 (4%)
Hemorrhage 1 (2%) 2 (4%)
Hydrometra 3 (6%) 6 (12%) 2 (4%) 8 (16%)
Hyperplasia, Cystic 5 (10%) 3 (6%) 2 (4%) 3 (6%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Endometrium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (49) (50)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Hyperplasia 2 (4%) 2 (4%) 3 (6%) 4 (8%)
Necrosis 1 (2%)
Lymph Node (4) (3) (5) (2)
Hyperplasia 1 (20%)
Iliac, Hyperplasia 1 (25%) 1 (20%) 1 (50%)
Pancreatic, Hyperplasia 1 (25%)
Renal, Hyperplasia 1 (33%)
Lymph Node, Bronchial (32) (31) (34) (38)
Congestion 1 (3%)
Hematopoietic Cell Proliferation 1 (3%) 1 (3%)
Hyperplasia 2 (6%) 3 (10%) 4 (12%) 3 (8%)
Lymph Node, Mandibular (32) (40) (33) (40)
Angiectasis 1 (3%)
Hematopoietic Cell Proliferation 1 (3%)
Hyperplasia 2 (6%) 2 (5%) 4 (10%)
Infiltration Cellular, Mast Cell 1 (3%)
Lymph Node, Mesenteric (48) (45) (48) (46)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 6 (13%) 1 (2%) 2 (4%) 2 (4%)
Inflammation, Chronic 1 (2%)
Lymph Node, Mediastinal (38) (44) (45) (40)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%) 7 (16%) 7 (18%)
Spleen (50) (49) (49) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 13 (26%) 25 (51%) 42 (86%) 39 (78%)
Hyperplasia, Lymphoid 9 (18%) 5 (10%) 1 (2%) 3 (6%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Thymus (44) (35) (39) (39)
Angiectasis 1 (2%) 1 (3%)
Atrophy 1 (2%) 3 (8%) 1 (3%)
Hyperplasia, Lymphoid 2 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (49) (50) (50)
Galactocele 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 3 (6%)
Skin (49) (49) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%) 3 (6%) 1 (2%)
Sebaceous Gland, Hyperplasia 2 (4%)
Subcutaneous Tissue, Inflammation,
Suppurative 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (50) (50)
Fibrous Osteodystrophy 15 (30%) 11 (22%) 6 (12%) 9 (18%)
Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Gliosis 1 (2%)
Hemorrhage 1 (2%)
Meninges, Inflammation, Chronic 3 (6%) 1 (2%)
Spinal Cord (1)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 1 (2%) 5 (10%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Epiglottis, Hyperplasia 1 (2%)
Lung (50) (49) (50) (50)
Angiectasis 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 14 (29%) 18 (36%) 23 (46%)
Inflammation, Chronic, Focal 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Bronchiole, Hyperplasia 15 (31%) 12 (24%) 30 (60%)
Perivascular, Infiltration Cellular 1 (2%) 1 (2%)
Nose (50) (49) (49) (50)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 3 (6%) 4 (8%)
Metaplasia 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Olfactory Epithelium, Atrophy 6 (12%) 5 (10%) 4 (8%) 47 (94%)
Olfactory Epithelium, Degeneration, Hyaline 3 (6%)
Olfactory Epithelium, Hyperplasia,
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Adenomatous 2 (4%) 3 (6%) 44 (88%)
Olfactory Epithelium, Metaplasia 2 (4%) 3 (6%) 1 (2%) 44 (88%)
Olfactory Epithelium, Glands, Inflammation,
Acute 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 17 (34%) 9 (18%) 10 (20%) 25 (50%)
Respiratory Epithelium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (50)
Hydronephrosis 1 (2%) 1 (2%) 4 (8%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Nephropathy 41 (82%) 35 (71%) 25 (51%) 20 (40%)
Pigmentation, Hemosiderin 1 (2%) 3 (6%)
Artery, Inflammation, Chronic 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Mineralization 1 (2%)
Renal Tubule, Necrosis 4 (8%)
Urinary Bladder (50) (47) (46) (47)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 15 16 26 34
Natural Death 8 7 10 3
Survivors
Terminal Sacrifice 27 27 14 13
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (49) (50) (50)
Dysplasia 1 (2%)
Inflammation, Suppurative 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Gallbladder (41) (40) (37) (40)
Degeneration, Hyaline 5 (12%) 1 (3%) 2 (5%) 3 (8%)
Inflammation, Suppurative 1 (2%) 1 (3%)
Necrosis 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Duodenum (45) (44) (45) (48)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Intestine Small, Jejunum (46) (43) (47) (49)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Small, Ileum (46) (45) (46) (48)
Peyer's Patch, Hyperplasia 1 (2%)
Liver (50) (50) (50) (49)
Angiectasis 2 (4%) 3 (6%) 1 (2%)
Basophilic Focus 4 (8%) 2 (4%) 1 (2%)
Clear Cell Focus 1 (2%) 1 (2%)
Congestion 1 (2%)
Degeneration, Cystic 1 (2%) 1 (2%)
Eosinophilic Focus 7 (14%) 7 (14%) 3 (6%) 8 (16%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Karyomegaly 19 (38%) 13 (26%) 20 (40%) 29 (59%)
Mitotic Alteration 1 (2%)
Necrosis 9 (18%) 7 (14%) 7 (14%) 6 (12%)
Regeneration 22 (44%) 25 (50%) 25 (50%) 27 (55%)
Vacuolization Cytoplasmic 1 (2%)
Bile Duct, Hyperplasia 34 (68%) 31 (62%) 34 (68%) 36 (73%)
Centrilobular, Necrosis 1 (2%)
Mesentery (2) (8) (16) (11)
Angiectasis 2 (13%)
Inflammation, Focal, Granulomatous 1 (9%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Thrombosis 1 (9%)
Fat, Inflammation, Chronic 1 (50%) 1 (13%)
Fat, Necrosis 1 (50%) 2 (25%) 1 (6%) 1 (9%)
Pancreas (50) (48) (49) (50)
Atrophy 4 (8%) 4 (8%) 2 (4%) 2 (4%)
Basophilic Focus 1 (2%)
Cytoplasmic Alteration 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Hypertrophy 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Duct, Cyst 1 (2%)
Salivary Glands (50) (49) (50) (50)
Inflammation 1 (2%)
Stomach, Forestomach (50) (48) (49) (50)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Suppurative 1 (2%) 3 (6%) 5 (10%)
Ulcer 2 (4%) 3 (6%) 1 (2%) 12 (24%)
Epithelium, Hyperplasia 4 (8%) 6 (13%) 7 (14%) 29 (58%)
Stomach, Glandular (50) (48) (50) (48)
Inflammation, Suppurative 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Necrosis 2 (4%) 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Tooth (2) (2)
Developmental Malformation 2 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2) (1) (1)
Inflammation 1 (100%)
Mineralization 1 (50%)
Heart (50) (49) (50) (50)
Cardiomyopathy 43 (86%) 43 (88%) 40 (80%) 45 (90%)
Hyperplasia, Atypical 1 (2%)
Inflammation 1 (2%)
Mineralization 1 (2%)
Artery, Inflammation 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (50)
Hyperplasia 2 (4%) 4 (8%) 3 (6%)
Hypertrophy 13 (26%) 15 (31%) 12 (24%) 9 (18%)
Capsule, Hyperplasia 2 (4%) 1 (2%)
Adrenal Medulla (50) (49) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 3 (6%) 3 (6%) 5 (10%) 2 (4%)
Islets, Pancreatic (50) (48) (49) (50)
Hyperplasia 1 (2%) 2 (4%) 2 (4%) 4 (8%)
Parathyroid Gland (35) (32) (31) (30)
Hyperplasia 1 (3%)
Pituitary Gland (49) (47) (47) (48)
Pars Distalis, Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Pars Nervosa, Inflammation 1 (2%)
Thyroid Gland (50) (49) (50) (50)
Follicular Cell, Hyperplasia 5 (10%) 5 (10%) 6 (12%) 7 (14%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (49) (50) (50)
Granuloma Sperm 3 (6%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Inflammation 1 (2%)
Preputial Gland (50) (47) (47) (50)
Angiectasis 1 (2%)
Cyst 2 (4%) 7 (15%) 2 (4%) 3 (6%)
Fibrosis 1 (2%)
Inflammation 2 (4%) 4 (9%) 3 (6%) 1 (2%)
Prostate (49) (48) (48) (49)
Hyperplasia 1 (2%)
Inflammation, Suppurative 2 (4%) 1 (2%) 2 (4%)
Seminal Vesicle (49) (48) (49) (48)
Inflammation 2 (4%) 2 (4%) 1 (2%)
Testes (50) (49) (50) (50)
Angiectasis 1 (2%)
Atrophy 2 (4%) 3 (6%) 2 (4%) 4 (8%)
Inflammation, Focal, Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (50)
Hyperplasia 3 (6%) 1 (2%) 3 (6%) 5 (10%)
Infiltration Cellular, Mast Cell 1 (2%)
Lymph Node (1) (2) (3)
Iliac, Hyperplasia 2 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Bronchial (32) (23) (33) (28)
Hyperplasia 4 (13%) 1 (4%) 2 (6%) 1 (4%)
Lymph Node, Mandibular (32) (28) (27) (34)
Hyperplasia 2 (6%) 2 (7%) 1 (4%)
Infiltration Cellular, Mast Cell 1 (4%)
Lymph Node, Mesenteric (47) (48) (46) (48)
Angiectasis 3 (6%) 3 (7%) 2 (4%)
Hyperplasia 2 (4%) 2 (4%) 2 (4%)
Lymph Node, Mediastinal (34) (38) (37) (37)
Hematopoietic Cell Proliferation 1 (3%)
Hyperplasia 1 (3%) 4 (11%) 2 (5%) 4 (11%)
Spleen (50) (49) (50) (50)
Accessory Spleen 1 (2%)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 26 (52%) 22 (45%) 35 (70%) 31 (62%)
Hyperplasia, Lymphoid 5 (10%) 3 (6%)
Infiltration Cellular, Histiocyte 1 (2%)
Thymus (34) (28) (25) (34)
Hyperplasia, Lymphoid 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (48) (50) (50)
Edema 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Epidermis, Hyperplasia 1 (2%)
Prepuce, Inflammation, Chronic Active 4 (8%) 6 (13%) 5 (10%) 1 (2%)
Subcutaneous Tissue, Cyst 2 (4%)
Subcutaneous Tissue, Inflammation, Focal,
Granulomatous 2 (4%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Meninges, Inflammation, Chronic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (47) (50) (50)
Hyperplasia 3 (6%) 2 (4%) 1 (2%) 4 (8%)
Inflammation, Suppurative 2 (4%)
Epiglottis, Metaplasia, Squamous 1 (2%) 1 (2%)
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 7 (14%) 8 (16%) 11 (22%) 22 (44%)
Inflammation, Chronic, Focal 2 (4%) 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 5 (10%) 2 (4%) 2 (4%)
Bronchiole, Hyperplasia 10 (20%) 18 (36%) 23 (46%)
Mediastinum, Inflammation, Chronic 1 (2%)
Perivascular, Infiltration Cellular 1 (2%)
Nose (50) (48) (50) (50)
Inflammation, Suppurative 2 (4%) 1 (2%) 4 (8%) 6 (12%)
Lateral Wall, Necrosis 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Olfactory Epithelium, Atrophy 7 (14%) 8 (17%) 7 (14%) 49 (98%)
Olfactory Epithelium, Degeneration, Hyaline 1 (2%) 2 (4%)
Olfactory Epithelium, Hyperplasia,
Adenomatous 3 (6%) 2 (4%) 2 (4%) 48 (96%)
Olfactory Epithelium, Metaplasia 6 (12%) 5 (10%) 5 (10%) 49 (98%)
Respiratory Epithelium, Degeneration, Hyaline 3 (6%) 4 (8%) 2 (4%) 10 (20%)
Respiratory Epithelium, Necrosis 1 (2%)
Respiratory Epithelium, Polyp, Inflammatory 1 (2%)
Trachea (50) (48) (50) (50)
Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (1)
Inflammation 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (50)
Cyst 1 (2%) 2 (4%) 1 (2%)
Glomerulosclerosis 2 (4%)
Hydronephrosis 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 4 (8%) 2 (4%) 3 (6%)
Metaplasia, Osseous 3 (6%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Nephropathy 47 (94%) 44 (90%) 43 (86%) 42 (84%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05136-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:54:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Papilla, Necrosis 1 (2%)
Renal Tubule, Hyperplasia 4 (8%) 5 (10%) 5 (10%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Ureter (1)
Transitional Epithelium, Hyperplasia 1 (100%)
Urinary Bladder (50) (48) (48) (50)
Inflammation, Suppurative 3 (6%) 1 (2%) 3 (6%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------