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TDMS Study 05136-08 Pathology Tables

NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11




       Facility:  Battelle Northwest

       Chemical CAS #:  0000126-99-8

       Lock Date:  04/14/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3|             
                                           | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                   X              X                                       |             
      Hepatocellular Adenoma               |                X        X                 X  X           X        X      |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                             X        X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +        +              +     +  +                           |             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                               +                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hemangiosarcoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +                                                                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X                             X                                       |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3|             
                                           | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  M  +  M  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                              X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                     X                                    |             
      Polyp Stromal                        | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +                                             |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  M  +  M  M  M  M  +  +|             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  M  +  +  +  M  M  M  +  +  +  M  +  M  M  M  +  M  +  M  +  +|             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +  +  M|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                             X        X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Lymphoma Malignant                   |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Carcinoma                            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                   X      |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3|             
                                           | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                   X      |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                      X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
      Adenoma                              |    X                                                                     |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                     X                       X        X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                X                                                         |          1 |
      Hepatocellular Carcinoma             |                               X                                   X      |          4 |
      Hepatocellular Adenoma               |                         X     X  X     X                 X           X   |         12 |
      Hepatocellular Adenoma, Multiple     |          X                                      X  X  X     X            |          5 |
      Histiocytic Sarcoma                  |                                                             X            |          1 |
      Lymphoma Malignant                   |                                                                X         |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                    +  +                 +                     |  10        |
      Lymphoma Malignant                   |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma              |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  +  M  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  M  +  M|  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Adenoma               |                               X  X                                       |          4 |
      Pars Intermedia, Adenoma             |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Adenoma             |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Cystadenoma                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                             X            |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Polyp Stromal                        |                                        X                                 |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                         +           +         |   4        |
      Pancreatic, Lymphoma Malignant       |          X                                                     X         |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  +  +  M  +  +  +  I  +  +  M  +  M  +  +  +  +  +  +  M  M  M  +|  32        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  I  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  M  +  +  +  M  M  +|  32        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  M  M  +  M  +  +  M  +  +  +  +  +  +  M  +|  38        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                   X                                                      |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                X                                                         |          1 |
      Histiocytic Sarcoma                  |                                                             X            |          1 |
      Lymphoma Malignant                   |          X                                   X        X        X         |          6 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|  44        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |             X                                                           X|          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                            X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                X                                                         |          2 |
      Alveolar/Bronchiolar Carcinoma       |                   X     X                                                |          2 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |             X                                                            |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                   X      |          1 |
      Histiocytic Sarcoma                  |                                                             X            |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   2        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                             X            |          1 |
      Lymphoma Malignant                   |          X                                   X        X        X         |          7 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3|             
                                           | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +|             
      Peyer's Patch, Lymphoma Malignant    |                                              X                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |          X     X              X        X                                 |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               | X     X  X        X                 X  X              X  X     X         |             
      Hepatocellular Adenoma, Multiple     |    X                             X                                       |             
      Hepatocholangiocarcinoma             |                                                                          |             
      Histiocytic Sarcoma                  |                                           X                              |             
      Lymphoma Malignant                   |                         X                                         X      |             
      Sarcoma, Metastatic, Mesentery       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +        +        +  +  +     +                           |             
      Hemangiosarcoma                      |                X                 X                                       |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |                                              X                           |             
      Sarcoma                              |       X                 X           X                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Sarcoma, Metastatic, Mesentery       |       X                             X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Mesentery       |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   9                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3|             
                                           | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  M  +  M  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Adenoma               |             X                    X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                     X                                    |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  M  M  +  +  +  +  M  +  +  +  +  M  +  +  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                X         |             
      Histiocytic Sarcoma                  |                                           X                              |             
      Luteoma                              |                                        X                                 |             
      Lymphoma Malignant                   |                                  X                                X      |             
      Teratoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                           X                              |             
      Leiomyosarcoma                       |                                                                          |             
      Polyp Stromal                        |                   X        X              X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +           +                 +         |             
      Lymphoma Malignant                   |                                  X                                       |             
      Iliac, Lymphoma Malignant            |                                  X           X                           |             
      Pancreatic, Lymphoma Malignant       |                                  X                                       |             
      Renal, Lymphoma Malignant            |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  M  +  +  M  +  +  +  +  +  +  +  +  M  M  M  +  +  +  M  +  +  +|             
      Lymphoma Malignant                   |                                  X                                X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  M  +|             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                X         |             
      Lymphoma Malignant                   |                                  X           X                    X      |             
      Sarcoma, Metastatic, Mesentery       |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  10                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3|             
                                           | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |                                  X           X                    X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant                   |                                  X                                X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                  X                                X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoacanthoma                       |                               X                                          |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                        X                    X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                           X                              |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant                        |                                                                   X      |             
      Subcutaneous Tissue, Sarcoma         | X        X           X        X                    X  X                 X|             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X           X                          X     X        X  X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |    X                                            X        X     X         |             
      Alveolar/Bronchiolar Carcinoma       |       X                                X                    X     X      |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |             X     X                                                      |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                            X                                             |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  11                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3|             
                                           | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                X                                                         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |                                  X                                X      |             
      Sarcoma, Metastatic, Skin            |                                                    X                     |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                         +   |             
      Adenoma                              |                                                                      X   |             
      Carcinoma                            |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Lymphoma Malignant                   |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                           X                              |             
      Lymphoma Malignant                   |                         X        X           X                    X     X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  12                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2|            |
                                           | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hepatocellular Carcinoma             | X  X           X     X        X           X                              |         10 |
      Hepatocellular Carcinoma, Multiple   |                                  X                                       |          1 |
      Hepatocellular Adenoma               |       X                                                        X  X      |         12 |
      Hepatocellular Adenoma, Multiple     |                      X     X     X           X              X            |          7 |
      Hepatocholangiocarcinoma             |       X                                                                  |          1 |
      Histiocytic Sarcoma                  |                                                          X               |          2 |
      Lymphoma Malignant                   |                                                                      X   |          3 |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +           +     +                    +        +        +  +      |  14        |
      Hemangiosarcoma                      |                   X     X                                                |          4 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X                                                                  |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Sarcoma                              |                                              X                           |          4 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X                                                                  |          1 |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2|            |
                                           | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X                                                                  |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Pheochromocytoma Malignant           |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  M  M  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  M  +  M|  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Pars Distalis, Adenoma               |                         X                    X     X              X      |          6 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                              X                    X      |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  A|  40        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Cystadenoma                          |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                          X               |          2 |
      Luteoma                              |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
      Teratoma Malignant                   |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Histiocytic Sarcoma                  |                                                          X               |          2 |
      Leiomyosarcoma                       |    X                                                                     |          1 |
      Polyp Stromal                        |                                                                   X      |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hemangiosarcoma                      |                                                 X                        |          1 |
      Lymphoma Malignant                   |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Iliac, Lymphoma Malignant            |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  14                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2|            |
                                           | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Lymphoma Malignant       |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  +  +  M  +  +  +  M  +  M  +  +  +  M  +  +  +  M  M  M  +  +  A|  31        |
      Lymphoma Malignant                   |                                                                      X   |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  A|  40        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  A|  45        |
      Hemangiosarcoma                      |                   X                                                      |          2 |
      Lymphoma Malignant                   |                                                                          |          3 |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|  44        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X                                                                  |          1 |
      Lymphoma Malignant                   |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hemangiosarcoma                      |                                                 X                        |          1 |
      Lymphoma Malignant                   |                X                                                     X   |          5 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M  M  +  +  +  +  +  +  +  M  +  +  +  M  M  +  M  M  +  +  +  M  M|  35        |
      Lymphoma Malignant                   |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Adenoacanthoma                       |                                                                          |          1 |
      Adenoma                              |                                              X                           |          1 |
      Carcinoma                            |                                                       X           X      |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Subcutaneous Tissue, Hemangiosarcoma |                                                 X                        |          1 |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant                        |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |          X     X                                                  X      |         10 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Multiple                         |                               X                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  15                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2|            |
                                           | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Alveolar/Bronchiolar Adenoma         |                   X     X  X                 X                           |         10 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                        X  X                              |          6 |
      Alveolar/Bronchiolar Carcinoma       |          X                                         X           X  X      |          8 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                            X  X  X                          X            |          6 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                      X                                                   |          1 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X                                                                  |          1 |
      Lymphoma Malignant                   |                                                                      X   |          3 |
      Sarcoma, Metastatic, Skin            |                X                                                         |          2 |
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |            |
           Skin                            |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +           +                          +     +      |   6        |
      Adenoma                              |                      X           X                                       |          3 |
      Carcinoma                            |                                                                   X      |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2|            |
                                           | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                          X               |          2 |
      Lymphoma Malignant                   |                X                                                     X   |          7 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  17                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0|             
                                           | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  A  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |             X                                                            |             
      Hepatocellular Carcinoma             | X              X                    X  X                          X      |             
      Hepatocellular Carcinoma, Multiple   |                               X           X  X     X                     |             
      Hepatocellular Adenoma               | X                                   X  X        X                    X   |             
      Hepatocellular Adenoma, Multiple     |                      X  X                                                |             
      Hepatocholangiocarcinoma             |                X                                                         |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +     +  +     +  +           +  +  +  +  +     +  +     +     +|             
      Hemangioma                           |                                        X                                 |             
      Hemangiosarcoma                      |       X        X  X     X                 X        X     X  X     X      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
      Sarcoma                              |                            X                 X  X                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                          X               |             
      Lymphoma Malignant                   |          X                                                               |             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |          X                                                               |             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0|             
                                           | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X              X                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  +  +  +  +  M  +  M  +  M  +  M  +  +  +  M  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
      Thyroglossal Duct, Adenoma           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  M  +  M  +  M  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Cystadenoma                          |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                   X                                               X      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
      Polyp Stromal                        |       X                                                                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                                                               |             
      Lymphoma Malignant                   |                                                                          |             
      Iliac, Hemangiosarcoma, Metastatic,  |                                                                          |             
           Mesentery                       |                                                                          |             
      Iliac, Lymphoma Malignant            |          X                                                               |             
      Renal, Lymphoma Malignant            |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  M  M  +  +  M  +  M  M  +  M  +  M  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0|             
                                           | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  I  +  +  +  M  +  M  +  M  M  M  I  M  +  M  +  +  +  +  +  M  M|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |             X                                                            |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                          X        X      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
      Sarcoma                              |                                                 X                        |             
      Sarcoma, Metastatic, Mesentery       |                            X                                             |             
      Sarcoma, Metastatic, Intestine Large,|                                                                          |             
           Colon                           |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Lymphoma Malignant                   |          X                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoacanthoma                       |                                  X                    X                  |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Carcinoma, Multiple                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |    X                                                                     |             
      Subcutaneous Tissue, Sarcoma         | X                    X              X  X        X  X           X        X|             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Metastatic, Mesentery            |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0|             
                                           | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |          X                                                               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoacanthoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                  X                    X                  |             
      Alveolar/Bronchiolar Adenoma         |    X              X  X           X     X        X  X  X  X               |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         | X              X        X                    X                    X      |             
      Alveolar/Bronchiolar Carcinoma       |          X           X                 X        X  X                     |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         | X                       X           X                                    |             
      Carcinoma, Metastatic, Mammary Gland |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                               X                                          |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                X                                                         |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
      Sarcoma, Metastatic, Mesentery       |                            X                                             |             
      Sarcoma, Metastatic, Skin            |                                                                X         |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinum, Hemangiosarcoma         |                                        X                                 |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Mesentery                       |                            X                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |          X                                                               |             
      Respiratory Epithelium, Adenoma      |                                                 X                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                     +|             
      Adenoma                              |                   X                                                     X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                          X               |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0|             
                                           | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                           X                              |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  22                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6|            |
                             DAY ON TEST   | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5|            |
                                           | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             | X                                                  X                     |          7 |
      Hepatocellular Carcinoma, Multiple   |    X                    X     X                                          |          7 |
      Hepatocellular Adenoma               | X                             X     X                                X   |          9 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          2 |
      Hepatocholangiocarcinoma             |                                                                          |          1 |
      Histiocytic Sarcoma                  |          X                                               X        X      |          3 |
      Lymphoma Malignant                   |                                                             X        X   |          3 |
      Sarcoma, Metastatic, Mesentery       |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +     +                 +  +  +  +  +        +           +  +     +   |  27        |
      Hemangioma                           | X                                                                        |          2 |
      Hemangiosarcoma                      |    X                       X           X                    X            |         13 |
      Histiocytic Sarcoma                  |          X                                                               |          1 |
      Lymphoma Malignant                   |                                                                      X   |          2 |
      Sarcoma                              |                               X  X  X           X              X         |          8 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +|  48        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                      X   |          2 |
      Sarcoma, Metastatic, Mesentery       |                                  X              X                        |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                      X   |          1 |
      Sarcoma, Metastatic, Skin            |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Sarcoma, Metastatic, Mesentery       |                                  X                             X         |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  23                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6|            |
                             DAY ON TEST   | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5|            |
                                           | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +|  48        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  I  M  I  +  +  +  +  M  +  M  +  +  M  M  +  +  M  +  +  M  +  M|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Adenoma               |                                     X  X                                X|          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Follicular Cell, Adenoma             |                                     X                                    |          1 |
      Thyroglossal Duct, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  M  +  +  M  +  M  M  +  +  M  +  +  +  M  +  +  +  M  M  +  +  +  +  M|  32        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      Cystadenoma                          |                                                    X                     |          1 |
      Histiocytic Sarcoma                  |                                                          X               |          1 |
      Lymphoma Malignant                   |                                                                      X   |          2 |
      Sarcoma, Metastatic, Mesentery       |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                          X        X      |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Polyp Stromal                        |                                                             X            |          2 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |    +                                                                     |   1        |
      Sarcoma                              |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Hemangiosarcoma                      |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  24                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6|            |
                             DAY ON TEST   | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5|            |
                                           | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                          +                 +                    +   |   5        |
      Lymphoma Malignant                   |                                                                      X   |          1 |
      Iliac, Hemangiosarcoma, Metastatic,  |                                                                          |            |
           Mesentery                       |    X                                                                     |          1 |
      Iliac, Lymphoma Malignant            |                                                                      X   |          2 |
      Renal, Lymphoma Malignant            |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  M  +  +  +  +  M  +  +  +  M  M  +  +  M  +  M  +  +  M  +  +|  34        |
      Histiocytic Sarcoma                  |          X                                                               |          1 |
      Lymphoma Malignant                   |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  M  +  M  +  +  +  +|  33        |
      Lymphoma Malignant                   |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |    X                                                                     |          3 |
      Histiocytic Sarcoma                  |          X                                               X               |          2 |
      Lymphoma Malignant                   |                                                                      X   |          2 |
      Sarcoma                              |                                                                          |          1 |
      Sarcoma, Metastatic, Mesentery       |                               X     X                          X         |          4 |
      Sarcoma, Metastatic, Intestine Large,|                                                                          |            |
           Colon                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +|  45        |
      Lymphoma Malignant                   |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Hemangiosarcoma                      |       X                                                                  |          1 |
      Histiocytic Sarcoma                  |          X                                                               |          1 |
      Lymphoma Malignant                   |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  M  +  M  M  M  M  +  +  M  +  +  +  +  +  A  +  +|  39        |
      Lymphoma Malignant                   |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoacanthoma                       |             X                                                            |          3 |
      Adenoma                              |                X                                                         |          1 |
      Carcinoma                            | X  X                 X           X        X                 X            |          6 |
      Carcinoma, Multiple                  |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Hemangiosarcoma |       X                                                                  |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  25                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6|            |
                             DAY ON TEST   | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5|            |
                                           | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Sarcoma         |                X        X                                                |         10 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Multiple                         |                                                       X                  |          1 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Metastatic, Mesentery            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                +         |   2        |
      Sarcoma, Metastatic, Mesentery       |                                                                X         |          1 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoacanthoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |             X                                                            |          3 |
      Alveolar/Bronchiolar Adenoma         |       X           X  X        X        X        X  X              X      |         17 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         | X  X                    X        X  X                 X     X            |         12 |
      Alveolar/Bronchiolar Carcinoma       |                X              X        X                                 |          8 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                         X        X           X     X                    X|          8 |
      Carcinoma, Metastatic, Mammary Gland |                      X                                      X            |          2 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                            X           X                                 |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |          X                                               X               |          2 |
      Lymphoma Malignant                   |                                                                      X   |          2 |
      Sarcoma, Metastatic, Mesentery       |                                  X                                       |          2 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  26                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6|            |
                             DAY ON TEST   | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5|            |
                                           | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                         X|          1 |
      Mediastinum, Hemangiosarcoma         |                                                                          |          1 |
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Respiratory Epithelium, Adenoma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                   +                     |   4        |
      Adenoma                              |                X                                                         |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                          X               |          1 |
      Lymphoma Malignant                   |                                                                      X   |          1 |
      Sarcoma, Metastatic, Mesentery       |                                  X              X                        |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +|  46        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                          X               |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Sarcoma, Metastatic, Mesentery       |                                  X  X                                    |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |          X                                               X        X      |          3 |
      Lymphoma Malignant                   |                                                             X        X   |          3 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  27                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3|             
                             DAY ON TEST   | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2|             
                                           | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |          X     X     X                                   X           X   |             
      Hepatocellular Carcinoma, Multiple   |                                        X                                 |             
      Hepatocellular Adenoma               |             X     X                          X        X           X      |             
      Hepatocellular Adenoma, Multiple     | X                                   X                                    |             
      Sarcoma, Metastatic, Mesentery       |                                                             X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +     +        +     +           +           +  +     +  +            |             
      Hemangioma                           |                                                          X               |             
      Hemangiosarcoma                      |          X              X                                                |             
      Sarcoma                              |                                                    X        X            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |          X                          X                                X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Mesentery       |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                           X                 X            |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  28                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3|             
                             DAY ON TEST   | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2|             
                                           | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                         X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                  X                 X                     |             
      Polyp Stromal                        |                                                             X            |             
      Sarcoma, Metastatic, Mesentery       |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                           +        +                     |             
      Iliac, Sarcoma, Metastatic, Mesentery|                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  M  +  M  +  +  +|             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |          X                                                               |             
      Lymphoma Malignant                   |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
      Sarcoma, Metastatic, Skin            | X                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  +  +  I  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoacanthoma                       |                                        X                                 |             
      Carcinoma                            |             X                                   X  X                     |             
      Carcinoma, Multiple                  |                X                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Sarcoma         | X  X  X                             X        X     X           X  X      |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  29                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3|             
                             DAY ON TEST   | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2|             
                                           | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Sarcoma, Metastatic, Skin            | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X        X                          X     X  X     X                  |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |          X     X  X     X  X                             X               |             
      Alveolar/Bronchiolar Carcinoma       |          X        X     X                 X     X              X         |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                      X           X  X              X  X  X        X  X  X|             
      Carcinoma, Metastatic, Mammary Gland |                                                 X                        |             
      Carcinoma, Metastatic, Zymbal's Gland|                            X     X                                       |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
      Sarcoma, Metastatic, Skin            | X                                   X                                    |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                      X                                                   |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                          |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Skin                            | X                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +           +                 +                 +  +               |             
      Adenoma                              | X     X                             X                 X  X               |             
      Carcinoma                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +     +                                       |             
      Carcinoma                            |                            X     X                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | I  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  30                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3|            |
                                           | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  M  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             | X     X     X  X     X                    X           X  X           X  X|         15 |
      Hepatocellular Carcinoma, Multiple   |    X                                            X  X                     |          4 |
      Hepatocellular Adenoma               |       X                          X                                       |          7 |
      Hepatocellular Adenoma, Multiple     |          X     X                       X        X  X  X           X      |          9 |
      Sarcoma, Metastatic, Mesentery       |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +        +              +  +     +  +     +  +     +           +  +|  21        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |    X                                                                    X|          4 |
      Sarcoma                              |                               X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Papilloma              |                                                                         X|          4 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  M  +  +  M  +  +  M  +  +  M|  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |                                                    X              X      |          4 |
      Pars Intermedia, Adenoma             |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  31                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3|            |
                                           | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  M  +  M  +  M  +  +  M  M  M  +  +  +  +  +  M  M  +  +  +  M  +  M|  35        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangioma                           |                                                                          |          2 |
      Polyp Stromal                        |                                                 X     X                  |          3 |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Iliac, Sarcoma, Metastatic, Mesentery|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  M  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +|  38        |
      Sarcoma, Metastatic, Mesentery       |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  M  +  M  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  M  M  +  M  +  +  +  +|  40        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                 X                        |          1 |
      Sarcoma, Metastatic, Mesentery       |                               X                                          |          1 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M|  39        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoacanthoma                       |       X                                                                  |          2 |
      Carcinoma                            |    X     X  X     X     X  X              X                    X         |         11 |
      Carcinoma, Multiple                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Papilloma              |                                                    X                     |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                          X               |          1 |
      Subcutaneous Tissue, Sarcoma         |                               X  X           X  X  X        X  X     X   |         16 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Multiple                         |                   X                                                      |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  32                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3|            |
                                           | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         | X                             X  X                          X            |         10 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |       X     X  X  X        X           X     X                 X     X  X|         16 |
      Alveolar/Bronchiolar Carcinoma       |       X     X              X  X  X                                       |         11 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |    X                 X                 X  X     X  X  X           X      |         17 |
      Carcinoma, Metastatic, Mammary Gland |                         X                                                |          2 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           | X           X        X                                X                  |          4 |
      Sarcoma, Metastatic, Mesentery       |                               X                                          |          1 |
      Sarcoma, Metastatic, Skin            |                                                                          |          2 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                 X                        |          2 |
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |            |
           Mesentery                       |                               X                                          |          1 |
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                          +                          +               |   9        |
      Adenoma                              |    X                          X                          X               |          8 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  33                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3|            |
                                           | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                             +            |   3        |
      Carcinoma                            |                                                             X            |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  34                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3|             
                                           | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  I  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Muscularis, Leiomyoma                |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                        X                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                         X|             
      Hepatocellular Carcinoma             |                      X        X  X        X     X                        |             
      Hepatocellular Carcinoma, Multiple   | X           X  X           X        X                 X                  |             
      Hepatocellular Adenoma               |                                                                X         |             
      Hepatocellular Adenoma, Multiple     |    X  X  X        X     X                                   X     X      |             
      Histiocytic Sarcoma                  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                                                                         X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                X                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  M  +  I  +  M  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  35                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3|             
                                           | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  +  M  M  +  M  M  +  +  M  M  +  +  M  +  +  +  M  +  +  I  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                      X                                   X               |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  M  +  +  +  M  +  M  M  +  +  +  +  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                      X                                                   |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  M  M  +  +  M  M  +  +  +  +  M  I  +  M  +  +  I  +  M  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |                                                    X                     |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                                      X                              |             
      Alveolar/Bronchiolar Carcinoma       |    X                                                        X           X|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  36                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3|             
                                           | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X                          X                                             |             
      Histiocytic Sarcoma                  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
      Adenoma                              |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                      +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                      X                                   X               |             
      Lymphoma Malignant                   |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  37                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7|            |
                             DAY ON TEST   | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3|            |
                                           | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  A  +  +  +  +  A  +  A  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Muscularis, Leiomyoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  M  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  46        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  46        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                         X|          2 |
      Hepatocellular Carcinoma             |             X        X                          X              X     X   |         10 |
      Hepatocellular Carcinoma, Multiple   |    X  X  X                 X     X        X              X  X            |         14 |
      Hepatocellular Adenoma               |    X              X              X  X  X           X        X            |          8 |
      Hepatocellular Adenoma, Multiple     | X                       X     X              X        X           X     X|         14 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                 +      |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Adenoma                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  M  +  +  +  +  M  +  I  +  M  +  +  +  +  +  +  +  M  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Adenoma               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  38                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7|            |
                             DAY ON TEST   | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3|            |
                                           | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  +  M  +  +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  M  M  M|  32        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  M  +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|  47        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant                   |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  M  M|  34        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  M  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  34        |
      Lymphoma Malignant                   |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          1 |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  39                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7|            |
                             DAY ON TEST   | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3|            |
                                           | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         | X     X     X                       X              X              X      |          8 |
      Alveolar/Bronchiolar Carcinoma       |                                                                         X|          4 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                              X        X                  |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X                    X                    X        X  X  X         |          8 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                            +                                             |   2        |
      Adenoma                              |                            X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                        X                                 |          3 |
      Lymphoma Malignant                   |             X                                                            |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  40                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3|             
                                           | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  M  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |          X                                                               |             
      Hepatoblastoma                       |             X                          X                                 |             
      Hepatocellular Carcinoma             |       X  X     X        X        X     X        X  X              X     X|             
      Hepatocellular Carcinoma, Multiple   | X                          X        X                 X  X     X     X   |             
      Hepatocellular Adenoma               |    X                                      X     X  X           X        X|             
      Hepatocellular Adenoma, Multiple     |                X                                                         |             
      Hepatocholangiocarcinoma             |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +                          +              +   |             
      Hemangiosarcoma                      |                      X     X                                             |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Sarcoma, Metastatic, Liver           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                               X                                          |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Sarcoma, Metastatic, Liver           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                     +                                    |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  M  +  +  +  +  +  M  +  I  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  41                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3|             
                                           | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Liver           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  M  +  +  M  M  M  M  M  +  +  +  +  +  M  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  M  +  M  +  +  M  M  M  +  +  +  +  +  +  +  M  M  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  I  +  +  M|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Liver           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                      X                                                   |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  M  M  M  I  +  M  I|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  42                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3|             
                                           | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |             
           Multiple                        |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X  X           X        X           X           X  X     X         |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                            X                 X                          X|             
      Alveolar/Bronchiolar Carcinoma       |             X     X                                                     X|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                X              X                                   X      |             
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                 X        X              X                    X   |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Sarcoma, Metastatic, Liver           |                                                                          |             
      Mediastinum,                         |                                                                          |             
          Hepatocholangiocarcinoma,        |                                                                          |             
          Metastatic, Liver                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                    +                             +|             
      Adenoma                              |                      X                    X                             X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Renal Tubule, Adenoma                |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3|             
                                           | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  44                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6|            |
                                           | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  +  A  +  +  M  +  +  A  +  +  A  +  +  A  +  +  +  +  +|  40        |
      Lymphoma Malignant                   |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +|  44        |
      Hemangioma                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                   X                    X  X                    X         |          5 |
      Hepatoblastoma                       |                                                                          |          2 |
      Hepatocellular Carcinoma             |    X                                X  X  X        X  X  X        X      |         18 |
      Hepatocellular Carcinoma, Multiple   |          X        X                                            X         |         10 |
      Hepatocellular Adenoma               | X        X              X  X     X                                       |         11 |
      Hepatocellular Adenoma, Multiple     |                X  X                                         X        X   |          5 |
      Hepatocholangiocarcinoma             |                                                 X                        |          1 |
      Lymphoma Malignant                   |    X                                                                     |          1 |
      Sarcoma                              |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                    +              +           +                        |   8        |
      Hemangiosarcoma                      |                      X                                                   |          3 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          1 |
      Sarcoma, Metastatic, Liver           |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          1 |
      Sarcoma, Metastatic, Liver           |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +           +                                                            |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                     +                                    |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  45                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6|            |
                                           | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  I  +  M  +  +  M  +  +  M  M  +  +  +  +  A  M  +  M  M  M|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Sarcoma, Metastatic, Liver           |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   1        |
      Lymphoma Malignant                   |    X                                                                     |          1 |
      Iliac, Lymphoma Malignant            |    X                                                                     |          1 |
      Renal, Lymphoma Malignant            |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  M  M  M  M  M  +  +  M  M  M  M  +  M  M  +  M  M  M  M  +  +  M|  23        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | I  +  +  M  M  M  M  +  M  +  M  +  +  +  +  +  +  M  M  A  M  M  M  M  +|  28        |
      Lymphoma Malignant                   |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Lymphoma Malignant                   |    X           X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  A  +  +  +  +  M|  38        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          1 |
      Lymphoma Malignant                   |    X                                                                     |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  46                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6|            |
                                           | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma, Metastatic, Liver           |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                   X                                                      |          2 |
      Lymphoma Malignant                   |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  M  M  +  +  +  M  M  +  +  +  M  M  +  M  M  +  +  M  M|  28        |
      Lymphoma Malignant                   |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Subcutaneous Tissue, Hemangiosarcoma |                X                                            X  X         |          3 |
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |            |
           Multiple                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         | X                                                     X  X        X      |         12 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |             X  X                          X                              |          6 |
      Alveolar/Bronchiolar Carcinoma       |          X        X  X     X  X                                          |          8 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |       X                                                                  |          4 |
      Hemangiosarcoma, Metastatic, Skin    |                                                             X            |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |    X     X                                X        X           X         |         10 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          1 |
      Sarcoma, Metastatic, Liver           |                                     X                                    |          1 |
      Mediastinum,                         |                                                                          |            |
          Hepatocholangiocarcinoma,        |                                                                          |            |
          Metastatic, Liver                |                                                 X                        |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  47                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6|            |
                                           | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Adenoma                              |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                         +      |   5        |
      Adenoma                              |                         X                                         X      |          5 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Lymphoma Malignant                   |    X                                                                     |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |    X           X                                                         |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  48                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6|             
                             DAY ON TEST   | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6|             
                                           | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  A  +  M  +  +  +  +  +  +  +  A  M  +  M  +  +  M  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                                                          |             
      Hemangiosarcoma                      |          X           X                                            X      |             
      Hepatoblastoma                       |                                                                X        X|             
      Hepatocellular Carcinoma             | X  X  X        X  X        X  X     X     X  X        X           X      |             
      Hepatocellular Carcinoma, Multiple   |          X  X                    X              X           X  X     X   |             
      Hepatocellular Adenoma               |    X     X                             X           X  X           X      |             
      Hepatocellular Adenoma, Multiple     | X                       X     X     X                                    |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +           +     +  +     +           +     +     +        +|             
      Hemangioma                           |       X                                                                  |             
      Hemangiosarcoma                      |             X           X     X  X     X           X     X              X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                    X                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Squamous Cell Papilloma              |                                     X           X                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  M  M  M  +  M  M  +  M  +  +  +  M  +  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  49                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6|             
                             DAY ON TEST   | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6|             
                                           | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                                         X|             
      Leiomyoma                            |                                           X                              |             
      Leiomyosarcoma                       |             X                                                            |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                             +            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                          X               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  M  M  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  M  +  M  +  I|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  M  +  M  +  +  M  +  +  +  +  +  M  M  M  M  M  M  M  M  +  M  M|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  +  +  M  M  +  +  M  M  +  +  M  +  +  +  +  M  +|             
      Lymphoma Malignant                   |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |             X                                                            |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  M  M  M  +  +  M  +  +  +  M  I  +  +  +  +  M  M  +  +  I|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |    X                                                                     |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  50                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6|             
                             DAY ON TEST   | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6|             
                                           | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X        X  X  X        X                    X  X                 X   |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         | X        X                          X                                    |             
      Alveolar/Bronchiolar Carcinoma       |       X     X           X           X                       X            |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                           X  X     X           X         |             
      Hepatoblastoma, Metastatic, Liver    |                                                                         X|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                     X     X  X        X                  |             
      Bronchiole, Adenoma                  |                                                    X                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                               X                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +        +              +     +                                          |             
      Adenoma                              | X                       X                                                |             
      Carcinoma                            |          X                    X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |             X                                      X                     |             
      Histiocytic Sarcoma                  |                                                                          |             
      Renal Tubule, Adenoma                | X                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                 X                 X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  51                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7|            |
                                           | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  M  +  M  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cholangiocarcinoma                   |    X                                                                     |          1 |
      Hemangiosarcoma                      | X     X                                         X                        |          6 |
      Hepatoblastoma                       |                               X                                          |          3 |
      Hepatocellular Carcinoma             |    X                             X           X     X  X        X         |         18 |
      Hepatocellular Carcinoma, Multiple   | X     X  X     X     X  X  X              X     X        X  X     X      |         19 |
      Hepatocellular Adenoma               |    X     X        X           X  X                                X      |         12 |
      Hepatocellular Adenoma, Multiple     |                X                                         X     X         |          7 |
      Histiocytic Sarcoma                  |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +     +                    +              +              +  +|  16        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |             X     X                    X              X              X   |         13 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangioma                           | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  M  M  +  M  M  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +|  31        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  52                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7|            |
                                           | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                                                          |          1 |
      Leiomyoma                            |                                                                          |          1 |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  I  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                         +|   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  +  +  +  M  M  M  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +|  33        |
      Histiocytic Sarcoma                  |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  M  +  +  +  +  M  +  +  M  +  M  +  +  +  M  +  +  +  +  M  M|  27        |
      Histiocytic Sarcoma                  |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|  46        |
      Hemangiosarcoma                      |                                                                   X      |          1 |
      Histiocytic Sarcoma                  |                X                                                         |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  M  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|  37        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                               X                                          |          2 |
      Histiocytic Sarcoma                  |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M  +  +  +  M  M  +  +  M  M  +  M  +  M  +  M  +  M  M  M  +  M  +|  25        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  53                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7|            |
                                           | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          1 |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                               X                                          |          1 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         | X     X     X                                      X  X     X     X      |         15 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                   X                    X                       X     X   |          7 |
      Alveolar/Bronchiolar Carcinoma       |          X  X           X     X        X                       X     X  X|         13 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                X           X        X           X           X     X      |         10 |
      Hepatoblastoma, Metastatic, Liver    |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                X         |          5 |
      Bronchiole, Adenoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +           +     +  +  +  +                 +               |  11        |
      Adenoma                              |             X           X     X  X  X  X                                 |          8 |
      Carcinoma                            |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  54                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7|            |
                                           | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                        X              X                  |          4 |
      Histiocytic Sarcoma                  |                X                                                         |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                X              X                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  55                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5|             
                                           | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  M  +  M  M  +  +  M  I  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                      X   |             
      Hemangiosarcoma                      |       X              X              X              X        X  X         |             
      Hepatoblastoma                       |                                        X                                 |             
      Hepatocellular Carcinoma             |          X  X     X        X  X                                X     X  X|             
      Hepatocellular Carcinoma, Multiple   | X  X           X        X        X  X                 X           X      |             
      Hepatocellular Adenoma               |       X  X        X                                               X     X|             
      Hepatocellular Adenoma, Multiple     |             X           X        X                       X     X         |             
      Hepatocholangiocarcinoma             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +           +  +                                +            |             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |       X     X                                               X            |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                   +                                                      |             
      Gingival, Squamous Cell Carcinoma    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                 X                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                      X   |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  56                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5|             
                                           | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  I  M  M  +  +  M  M  +  +  M  +  M  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                      X     X                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +              +                                                   |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
      Renal, Hemangiosarcoma               |       X                                                                  |             
      Renal, Lymphoma Malignant            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  M  M  M  +  M  M  M  +  M  +  +  +  +  M  M  +  M  M  +  M|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                         X                                            X   |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  M  +  +  M  +  +  +  M  +  M  +  M  M  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant                   |                      X           X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  I  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  57                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5|             
                                           | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  I  +  M  M  +  +  +  M  +  +  +  M  +  M  M  M  +  +  +  +  M  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |                      X     X                 X        X     X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X           X     X              X  X           X  X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         | X                 X     X              X  X                              |             
      Alveolar/Bronchiolar Carcinoma       |                         X     X  X                    X           X      |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |       X     X                       X                    X     X     X  X|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                                          |             
      Hepatoblastoma, Metastatic, Liver    |                                        X                                 |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |          X                    X                                   X      |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                 X                        |             
      Lymphoma Malignant                   |                      X                                                   |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                      X   |             
      Mediastinum,                         |                                                                          |             
          Hepatocholangiocarcinoma,        |                                                                          |             
          Metastatic, Liver                |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  58                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5|             
                                           | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                                                        |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                      X   |             
      Respiratory Epithelium, Adenoma      |                   X                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  M     +                       +     +              +  +            |             
      Adenoma                              |                                     X     X              X  X            |             
      Carcinoma                            |             X                                                            |             
      Bilateral, Adenoma                   | X                                                                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | M  M  M                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                      X   |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                 X                        |             
      Lymphoma Malignant                   |                      X                                                   |             
      Renal Tubule, Adenoma                |                                                                         X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                      X           X                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  59                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 5| 7| 6| 6| 7| 6| 5| 5| 6|            |
                             DAY ON TEST   | 9| 3| 8| 3| 3| 4| 3| 4| 0| 2| 3| 7| 2| 7| 3| 4| 2| 3| 2| 7| 3| 6| 6| 8| 5|            |
                                           | 5| 3| 7| 5| 3| 9| 3| 4| 0| 8| 7| 7| 0| 2| 3| 9| 3| 3| 4| 7| 3| 3| 7| 9| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  M  +  M  A  +  +  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant                   |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                X        X|          8 |
      Hepatoblastoma                       |                                                                          |          1 |
      Hepatocellular Carcinoma             |          X  X     X                          X  X        X  X           X|         16 |
      Hepatocellular Carcinoma, Multiple   | X                    X           X        X        X  X        X  X  X   |         17 |
      Hepatocellular Adenoma               |       X     X              X        X                 X           X      |         11 |
      Hepatocellular Adenoma, Multiple     |                X  X     X     X                                X         |         10 |
      Hepatocholangiocarcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +              +        +     +        +              +               |  11        |
      Hemangioma                           |    X                                                     X               |          2 |
      Hemangiosarcoma                      |                   X        X     X        X                              |          7 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Gingival, Squamous Cell Carcinoma    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma              |          X                                                               |          1 |
      Squamous Cell Papilloma              |       X              X           X                                   X   |          4 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                      X   |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  60                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 5| 7| 6| 6| 7| 6| 5| 5| 6|            |
                             DAY ON TEST   | 9| 3| 8| 3| 3| 4| 3| 4| 0| 2| 3| 7| 2| 7| 3| 4| 2| 3| 2| 7| 3| 6| 6| 8| 5|            |
                                           | 5| 3| 7| 5| 3| 9| 3| 4| 0| 8| 7| 7| 0| 2| 3| 9| 3| 3| 4| 7| 3| 3| 7| 9| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  M  +  M|  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Adenoma             |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant                   |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                             +            |   3        |
      Pancreatic, Lymphoma Malignant       |                                                             X            |          1 |
      Renal, Hemangiosarcoma               |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  +  M  +  +  +  +  +  +  M  +  M  +  +  +  M  M  +  +  +  M  +  M|  28        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                     X                                X   |          4 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  61                                                               
NTP Experiment-Test: 05136-08                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 03/17/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:23:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 5| 7| 6| 6| 7| 6| 5| 5| 6|            |
                             DAY ON TEST   | 9| 3| 8| 3| 3| 4| 3| 4| 0| 2| 3| 7| 2| 7| 3| 4| 2| 3| 2| 7| 3| 6| 6| 8| 5|            |
                                           | 5| 3| 7| 5| 3| 9| 3| 4| 0| 8| 7| 7| 0| 2| 3| 9| 3| 3| 4| 7| 3| 3| 7| 9| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  M  +|  34        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant                   |                X                                            X            |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  I  +  +  +  +  M  +  M  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  M|  37        |
      Alveolar/Bronchiolar Carcinoma,      |