TDMS Study 05136-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest CHLOROPRENE DATE: 10/04/96
EXPERIMENT: 05136 TEST: 08 TIME: 09:59:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-05291 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 50522B
PATHOLOGIST: R. MILLER CAS: 0000126-99-8
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest CHLOROPRENE DATE: 10/04/96
EXPERIMENT: 05136 TEST: 08 TIME: 09:59:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05291 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 50522B
PATHOLOGIST: R. MILLER CAS: 0000126-99-8
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest CHLOROPRENE DATE: 10/04/96
EXPERIMENT: 05136 TEST: 08 TIME: 09:59:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05291 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 50522B
PATHOLOGIST: R. MILLER CAS: 0000126-99-8
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 9-8CHLOROPRENE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Hemangiosarcoma
Harderian Gland Adenoma
Carcinoma
Carcinoma or Adenoma
Kidney: Renal Tubule Adenoma
Liver Hemangiosarcoma
Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Mesentery Hemangioma
Hemangiosarcoma
Nose Adenoma
Skin Hemangiosarcoma
Stomach, Forestomach Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest CHLOROPRENE DATE: 10/04/96
EXPERIMENT: 05136 TEST: 08 TIME: 09:59:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05291 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 50522B
PATHOLOGIST: R. MILLER CAS: 0000126-99-8
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 9-8CHLOROPRENE
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Mammary Gland Carcinoma
Carcinoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Mesentery Hemangioma
Hemangiosarcoma
Sarcoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin Sarcoma
Stomach, Forestomach Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
Uterus Hemangioma
Polyp Stromal
Zymbal's Gland Carcinoma
All Organs Hemangioma
Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated
Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/49 (2%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 1/49 (2%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 3.7% 8.5% 3.3% | 0.0% 2.2% 3.6% 0.0% |
|TERMINAL (d) | 0/27 (0%) 1/27 (4%) 0/14 (0%) 0/13 (0%) | 0/35 (0%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 607 644 | --- 482 551 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.301 P=0.500 P=0.159 P=0.458 | P=0.615N P=0.487 P=0.410 (e) |
|INCIDENTAL TUMOR | P=0.506 P=0.500 P=0.313 P=0.587 | P=0.336N P=0.536 P=0.846 (e) |
|LOGISTIC REGRESSION | P=0.430 P=0.500 P=0.239 P=0.533 | P=0.457N P=0.489 P=0.566 (e) |
|COCHRAN-ARMITAGE | P=0.450 | P=0.558N |
|FISHER EXACT | P=0.495 P=0.247 P=0.500 | P=0.495 P=0.495 (e) |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/47 (0%) 0/47 (0%) 2/50 (4%) | 0/41 (0%) 0/40 (0%) 0/32 (0%) 0/35 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 10.1% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/25 (0%) 0/13 (0%) 1/13 (8%) | 0/33 (0%) 0/14 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 603 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.021 * (e) (e) P=0.149 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.037 * (e) (e) P=0.201 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.041 * (e) (e) P=0.227 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.046 * | (e) |
|FISHER EXACT | (e) (e) P=0.247 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 8/50 (16%) 10/50 (20%) | 1/50 (2%) 3/50 (6%) 3/50 (6%) 8/50 (16%) |
|ADJUSTED (b) | 5.8% 17.7% 36.8% 46.4% | 2.9% 14.9% 12.0% 74.4% |
|TERMINAL (d) | 1/27 (4%) 4/27 (15%) 4/14 (29%) 4/13 (31%) | 1/35 (3%) 2/16 (13%) 0/1 (0%) 2/3 (67%) |
|FIRST INCIDENCE (DAYS) | 596 701 596 589 | 734 (T) 621 524 467 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.213 P=0.009 ** P=0.001 ** | P<0.001 ** P=0.120 P=0.048 * P<0.001 ** |
|INCIDENTAL TUMOR | P=0.005 ** P=0.207 P=0.021 * P=0.010 * | P=0.003 ** P=0.188 P=0.526 P=0.009 ** |
|LOGISTIC REGRESSION | P=0.004 ** P=0.205 P=0.035 * P=0.007 ** | P=0.001 ** P=0.225 P=0.293 P=0.007 ** |
|COCHRAN-ARMITAGE | P=0.013 * | P=0.006 ** |
|FISHER EXACT | P=0.218 P=0.046 * P=0.014 * | P=0.309 P=0.309 P=0.015 * |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 2/50 (4%) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 8.7% 15.4% | 2.2% 9.6% 0.0% 10.0% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 2/13 (15%) | 0/35 (0%) 1/16 (6%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 635 733 (T) | 527 680 --- 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.030 * (e) P=0.154 P=0.097 | P=0.349 P=0.367 P=0.566N P=0.580 |
|INCIDENTAL TUMOR | P=0.084 (e) P=0.313 P=0.097 | P=0.638N P=0.536 P=0.227N P=0.598N |
|LOGISTIC REGRESSION | P=0.058 (e) P=0.226 P=0.097 | P=0.639N P=0.516 P=0.421N P=0.736N |
|COCHRAN-ARMITAGE | P=0.106 | P=0.532N |
|FISHER EXACT | (e) P=0.247 P=0.247 | P=0.500 P=0.500N P=0.753N |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 10/50 (20%) 12/50 (24%) | 2/50 (4%) 5/50 (10%) 3/50 (6%) 9/50 (18%) |
|ADJUSTED (b) | 5.8% 17.7% 42.3% 58.3% | 5.0% 23.8% 12.0% 77.0% |
|TERMINAL (d) | 1/27 (4%) 4/27 (15%) 4/14 (29%) 6/13 (46%) | 1/35 (3%) 3/16 (19%) 0/1 (0%) 2/3 (67%) |
|FIRST INCIDENCE (DAYS) | 596 701 596 589 | 527 621 524 467 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.213 P=0.002 ** P<0.001 ** | P<0.001 ** P=0.065 P=0.157 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.207 P=0.008 ** P=0.001 ** | P=0.008 ** P=0.155 P=0.583N P=0.045 * |
|LOGISTIC REGRESSION | P<0.001 ** P=0.205 P=0.010 * P=0.001 ** | P=0.004 ** P=0.186 P=0.577 P=0.016 * |
|COCHRAN-ARMITAGE | P=0.003 ** | P=0.018 * |
|FISHER EXACT | P=0.218 P=0.014 * P=0.004 ** | P=0.218 P=0.500 P=0.026 * |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/48 (0%) 0/49 (0%) 0/50 (0%) | 0/49 (0%) 1/49 (2%) 2/48 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 3.4% 10.9% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 0/13 (0%) | 0/35 (0%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 677 543 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.542 P=0.436 P=0.089 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.366N P=0.718 P=0.602 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.560N P=0.493 P=0.268 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.549N |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.242 (e) |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/49 (2%) 1/50 (2%) 3/50 (6%) | 0/50 (0%) 0/49 (0%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 3.6% 7.1% 13.8% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 1/14 (7%) 1/13 (8%) | 0/35 (0%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- 722 733 (T) 587 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.014 * P=0.486 P=0.369 P=0.060 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.056 P=0.479 P=0.369 P=0.123 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.039 * P=0.492 P=0.369 P=0.121 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.060 | (e) |
|FISHER EXACT | P=0.495 P=0.500 P=0.121 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 6/50 (12%) 8/49 (16%) | 1/50 (2%) 0/49 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 7.4% 16.3% 25.4% 30.3% | 2.9% 0.0% 2.0% 0.0% |
|TERMINAL (d) | 2/27 (7%) 3/27 (11%) 2/14 (14%) 1/13 (8%) | 1/35 (3%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 659 495 579 | 734 (T) --- 216 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003 ** P=0.219 P=0.039 * P=0.008 ** | P=0.676N P=0.656N P=0.525 P=0.941N |
|INCIDENTAL TUMOR | P=0.044 * P=0.205 P=0.111 P=0.052 | P=0.520N P=0.656N P=0.652 P=0.941N |
|LOGISTIC REGRESSION | P=0.031 * P=0.201 P=0.108 P=0.036 * | P=0.319N P=0.656N P=0.666N P=0.941N |
|COCHRAN-ARMITAGE | P=0.045 * | P=0.439N |
|FISHER EXACT | P=0.218 P=0.134 P=0.043 * | P=0.505N P=0.753N P=0.500N |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 3/50 (6%) 1/49 (2%) | 0/50 (0%) 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.7% 12.6% 3.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 1/27 (4%) 0/14 (0%) 0/13 (0%) | 0/35 (0%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- 523 607 635 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.392 P=0.240 P=0.063 P=0.462 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.605N P=0.314 P=0.189 P=0.587 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.591 P=0.254 P=0.116 P=0.540 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.544 | (e) |
|FISHER EXACT | P=0.247 P=0.121 P=0.495 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/50 (44%) 16/50 (32%) 19/50 (38%) 21/49 (43%) | 17/50 (34%) 19/49 (39%) 11/50 (22%) 16/50 (32%) |
|ADJUSTED (b) | 64.4% 47.9% 72.3% 67.7% | 47.0% 69.1% 100.0% 85.1% |
|TERMINAL (d) | 15/27 (56%) 11/27 (41%) 8/14 (57%) 6/13 (46%) | 16/35 (46%) 9/16 (56%) 1/1 (100%) 1/3 (33%) |
|FIRST INCIDENCE (DAYS) | 635 439 439 392 | 637 523 505 383 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.006 ** P=0.175N P=0.090 P=0.044 * | P<0.001 ** P=0.005 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.189 P=0.159N P=0.523 P=0.420 | P=0.041 * P=0.101 P=0.071 P=0.037 * |
|LOGISTIC REGRESSION | P=0.183 P=0.156N P=0.419 P=0.381 | P=0.070 P=0.157 P=0.064 P=0.141 |
|COCHRAN-ARMITAGE | P=0.397 | P=0.359N |
|FISHER EXACT | P=0.151N P=0.342N P=0.535N | P=0.388 P=0.133N P=0.500N |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/50 (48%) 28/50 (56%) 37/50 (74%) 33/49 (67%) | 4/50 (8%) 11/49 (22%) 14/50 (28%) 19/50 (38%) |
|ADJUSTED (b) | 50.8% 63.2% 91.5% 87.2% | 10.3% 41.8% 100.0% 91.5% |
|TERMINAL (d) | 6/27 (22%) 12/27 (44%) 11/14 (79%) 9/13 (69%) | 2/35 (6%) 4/16 (25%) 1/1 (100%) 2/3 (67%) |
|FIRST INCIDENCE (DAYS) | 452 523 382 392 | 493 440 503 524 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.301 P<0.001 ** P=0.003 ** | P<0.001 ** P=0.004 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.139 P=0.268 P=0.049 * P=0.201 | P=0.001 ** P=0.056 P=0.070 P=0.008 ** |
|LOGISTIC REGRESSION | P=0.131 P=0.295 P=0.047 * P=0.189 | P<0.001 ** P=0.040 * P=0.002 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.033 * | P<0.001 ** |
|FISHER EXACT | P=0.274 P=0.007 ** P=0.040 * | P=0.041 * P=0.009 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/50 (48%) 29/50 (58%) 39/50 (78%) 34/49 (69%) | 4/50 (8%) 11/49 (22%) 14/50 (28%) 19/50 (38%) |
|ADJUSTED (b) | 50.8% 65.7% 92.1% 87.6% | 10.3% 41.8% 100.0% 91.5% |
|TERMINAL (d) | 6/27 (22%) 13/27 (48%) 11/14 (79%) 9/13 (69%) | 2/35 (6%) 4/16 (25%) 1/1 (100%) 2/3 (67%) |
|FIRST INCIDENCE (DAYS) | 452 523 382 392 | 493 440 503 524 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.253 P<0.001 ** P=0.002 ** | P<0.001 ** P=0.004 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.110 P=0.202 P=0.019 * P=0.154 | P=0.001 ** P=0.056 P=0.070 P=0.008 ** |
|LOGISTIC REGRESSION | P=0.099 P=0.221 P=0.018 * P=0.141 | P<0.001 ** P=0.040 * P=0.002 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.022 * | P<0.001 ** |
|FISHER EXACT | P=0.212 P=0.002 ** P=0.025 * | P=0.041 * P=0.009 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 43/50 (86%) 37/50 (74%) 42/50 (84%) 41/49 (84%) | 20/50 (40%) 26/49 (53%) 20/50 (40%) 30/50 (60%) |
|ADJUSTED (b) | 87.7% 81.5% 97.5% 94.6% | 52.2% 81.8% 100.0% 100.0% |
|TERMINAL (d) | 21/27 (78%) 19/27 (70%) 13/14 (93%) 11/13 (85%) | 17/35 (49%) 11/16 (69%) 1/1 (100%) 3/3 (100%) |
|FIRST INCIDENCE (DAYS) | 452 439 382 392 | 493 440 503 383 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** P=0.272N P=0.014 * P=0.015 * | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.521 P=0.088N P=0.442N P=0.361N | P<0.001 ** P=0.030 * P=0.039 * P<0.001 ** |
|LOGISTIC REGRESSION | P=0.530 P=0.087N P=0.463N P=0.402N | P<0.001 ** P=0.051 P=0.011 * P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.432 | P=0.054 |
|FISHER EXACT | P=0.105N P=0.500N P=0.483N | P=0.135 P=0.581N P=0.036 * |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 43/50 (86%) 38/50 (76%) 43/50 (86%) 42/49 (86%) | 20/50 (40%) 26/49 (53%) 20/50 (40%) 30/50 (60%) |
|ADJUSTED (b) | 87.7% 83.8% 97.6% 94.8% | 52.2% 81.8% 100.0% 100.0% |
|TERMINAL (d) | 21/27 (78%) 20/27 (74%) 13/14 (93%) 11/13 (85%) | 17/35 (49%) 11/16 (69%) 1/1 (100%) 3/3 (100%) |
|FIRST INCIDENCE (DAYS) | 452 439 382 392 | 493 440 503 383 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001 ** P=0.320N P=0.010 ** P=0.011 * | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.447 P=0.132N P=0.535N P=0.447N | P<0.001 ** P=0.030 * P=0.039 * P<0.001 ** |
|LOGISTIC REGRESSION | P=0.441 P=0.132N P=0.580N P=0.503N | P<0.001 ** P=0.051 P=0.011 * P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.353 | P=0.054 |
|FISHER EXACT | P=0.154N P=0.613N P=0.597N | P=0.135 P=0.581N P=0.036 * |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 18/50 (36%) 22/50 (44%) 28/50 (56%) | 2/50 (4%) 16/49 (33%) 29/50 (58%) 26/50 (52%) |
|ADJUSTED (b) | 23.8% 54.8% 68.3% 84.7% | 5.7% 57.9% 100.0% 100.0% |
|TERMINAL (d) | 4/27 (15%) 13/27 (48%) 6/14 (43%) 9/13 (69%) | 2/35 (6%) 6/16 (38%) 1/1 (100%) 3/3 (100%) |
|FIRST INCIDENCE (DAYS) | 635 530 382 523 | 734 (T) 447 346 453 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.023 * P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.020 * P=0.005 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.016 * P=0.002 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.020 * P=0.002 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 12/50 (24%) 23/50 (46%) 28/50 (56%) | 2/50 (4%) 14/49 (29%) 16/50 (32%) 28/50 (56%) |
|ADJUSTED (b) | 21.3% 37.9% 76.7% 85.1% | 5.5% 51.9% 100.0% 95.4% |
|TERMINAL (d) | 5/27 (19%) 8/27 (30%) 8/14 (57%) 9/13 (69%) | 1/35 (3%) 6/16 (38%) 1/1 (100%) 2/3 (67%) |
|FIRST INCIDENCE (DAYS) | 729 638 567 524 | 706 447 524 324 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.096 P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.083 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.001 ** P=0.004 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.075 P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.096 P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/50 (26%) 28/50 (56%) 36/50 (72%) 43/50 (86%) | 4/50 (8%) 28/49 (57%) 34/50 (68%) 42/50 (84%) |
|ADJUSTED (b) | 39.2% 79.4% 89.0% 100.0% | 11.0% 83.5% 100.0% 100.0% |
|TERMINAL (d) | 8/27 (30%) 20/27 (74%) 10/14 (71%) 13/13 (100%)| 3/35 (9%) 11/16 (69%) 1/1 (100%) 3/3 (100%) |
|FIRST INCIDENCE (DAYS) | 635 530 382 523 | 706 447 346 324 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.003 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.002 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 5.3% 0.0% | 0.0% 10.0% 2.0% 3.3% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 0/13 (0%) | 0/35 (0%) 1/16 (6%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 701 --- | --- 691 216 576 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.711 (e) P=0.402 (e) | P=0.225 P=0.121 P=0.504 P=0.424 |
|INCIDENTAL TUMOR | P=0.734N (e) P=0.581 (e) | P=0.595 P=0.233 P=0.638 P=0.864 |
|LOGISTIC REGRESSION | P=0.754 (e) P=0.451 (e) | P=0.651N P=0.172 P=0.403 P=0.550 |
|COCHRAN-ARMITAGE | P=0.778 | P=0.574 |
|FISHER EXACT | (e) P=0.500 (e) | P=0.247 P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 3/50 (6%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 2.1% 7.7% 7.9% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 0/13 (0%) | 0/35 (0%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 440 425 582 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.147 P=0.492 P=0.091 P=0.128 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.551 P=0.536 P=0.440 P=0.696 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.355 P=0.496 P=0.205 P=0.252 |
|COCHRAN-ARMITAGE | (e) | P=0.216 |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.121 P=0.247 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 4/50 (8%) 7/50 (14%) 12/50 (24%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 7.4% 13.6% 35.1% 56.4% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 0/13 (0%) | 1/35 (3%) 1/16 (6%) 0/1 (0%) 1/3 (33%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 527 447 394 336 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P<0.001 ** P=0.322 P=0.003 ** P<0.001 ** |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.042 * P=0.564 P=0.634N P=0.220 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.008 ** P=0.553 P=0.207 P=0.036 * |
|COCHRAN-ARMITAGE | (e) | P=0.003 ** |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.159 P=0.011 * |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 5/50 (10%) 8/50 (16%) 12/50 (24%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 7.4% 18.4% 37.0% 56.4% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 0/13 (0%) | 1/35 (3%) 1/16 (6%) 0/1 (0%) 1/3 (33%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 527 447 394 336 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P<0.001 ** P=0.179 P=0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.071 P=0.470 P=0.637 P=0.220 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.013 * P=0.397 P=0.152 P=0.036 * |
|COCHRAN-ARMITAGE | (e) | P=0.005 ** |
|FISHER EXACT | (e) (e) (e) | P=0.357 P=0.100 P=0.011 * |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 5/50 (10%) 8/50 (16%) 12/50 (24%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 7.4% 18.4% 37.0% 56.4% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 0/13 (0%) | 1/35 (3%) 1/16 (6%) 0/1 (0%) 1/3 (33%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 527 447 394 336 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P<0.001 ** P=0.179 P=0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.071 P=0.470 P=0.637 P=0.220 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.013 * P=0.397 P=0.152 P=0.036 * |
|COCHRAN-ARMITAGE | (e) | P=0.005 ** |
|FISHER EXACT | (e) (e) (e) | P=0.357 P=0.100 P=0.011 * |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Mesentery |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 2.8% 12.6% | 0.0% 0.0% 100.0% 33.3% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 1/13 (8%) | 0/35 (0%) 0/16 (0%) 1/1 (100%) 1/3 (33%) |
|FIRST INCIDENCE (DAYS) | --- --- 607 677 | --- --- 607 734 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.032 * (e) P=0.465 P=0.112 | P=0.023 * (e) P=0.010 * P=0.059 |
|INCIDENTAL TUMOR | P=0.085 (e) P=0.548 P=0.198 | P=0.071 (e) P=0.056 P=0.059 |
|LOGISTIC REGRESSION | P=0.068 (e) P=0.579 P=0.154 | P=0.078 (e) P=0.072 P=0.059 |
|COCHRAN-ARMITAGE | P=0.077 | P=0.307 |
|FISHER EXACT | (e) P=0.500 P=0.247 | (e) P=0.247 P=0.500 |
|=================================================================================================================================|
| |
|Mesentery |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 13/50 (26%) 7/50 (14%) | 0/50 (0%) 4/50 (8%) 13/50 (26%) 4/50 (8%) |
|ADJUSTED (b) | 0.0% 10.1% 51.1% 40.3% | 0.0% 18.6% 59.3% 15.8% |
|TERMINAL (d) | 0/27 (0%) 2/27 (7%) 4/14 (29%) 4/13 (31%) | 0/35 (0%) 1/16 (6%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- 680 502 628 | --- 691 389 523 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.123 P<0.001 ** P<0.001 ** | P=0.008 ** P=0.015 * P<0.001 ** P=0.016 * |
|INCIDENTAL TUMOR | P=0.015 * P=0.116 P<0.001 ** P=0.003 ** | P=0.458N P=0.117 P=0.058 P=0.414 |
|LOGISTIC REGRESSION | P=0.006 ** P=0.114 P<0.001 ** P=0.001 ** | P=0.525N P=0.032 * P<0.001 ** P=0.072 |
|COCHRAN-ARMITAGE | P=0.023 * | P=0.206 |
|FISHER EXACT | P=0.121 P<0.001 ** P=0.006 ** | P=0.059 P<0.001 ** P=0.059 |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Mesentery |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 4/50 (8%) 8/50 (16%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 16.3% 46.5% 12.6% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 0/13 (0%) | 0/35 (0%) 1/16 (6%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 523 463 443 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.018 * P=0.023 * P<0.001 ** P=0.041 * |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.519N P=0.094 P=0.120 P=0.485 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.308 P=0.060 P=0.004 ** P=0.157 |
|COCHRAN-ARMITAGE | (e) | P=0.313 |
|FISHER EXACT | (e) (e) (e) | P=0.059 P=0.003 ** P=0.121 |
|=================================================================================================================================|
| |
|Nose |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/48 (0%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/49 (0%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 13.1% | 0.0% 0.0% 12.5% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 1/13 (8%) | 0/35 (0%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 680 | --- --- 656 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.010 ** (e) (e) P=0.103 | P=0.623 (e) P=0.181 (e) |
|INCIDENTAL TUMOR | P=0.032 * (e) (e) P=0.198 | P=0.785 (e) P=0.581 (e) |
|LOGISTIC REGRESSION | P=0.021 * (e) (e) P=0.150 | P=0.759 (e) P=0.416 (e) |
|COCHRAN-ARMITAGE | P=0.044 * | P=0.778 |
|FISHER EXACT | (e) (e) P=0.247 | (e) P=0.495 (e) |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/47 (0%) 0/47 (0%) 0/48 (0%) | 4/49 (8%) 6/48 (13%) 4/48 (8%) 4/50 (8%) |
|ADJUSTED (b) | 2.8% 0.0% 0.0% 0.0% | 11.1% 30.5% 31.6% 34.7% |
|TERMINAL (d) | 0/26 (0%) 0/26 (0%) 0/12 (0%) 0/13 (0%) | 3/35 (9%) 3/15 (20%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | 666 --- --- --- | 729 636 620 443 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.490N P=0.506N P=0.557N P=0.617N | P=0.006 ** P=0.056 P=0.002 ** P=0.027 * |
|INCIDENTAL TUMOR | P=0.352N P=0.521N P=0.433N P=0.433N | P=0.437 P=0.282 P=0.505 P=0.504 |
|LOGISTIC REGRESSION | P=0.406N P=0.508N P=0.510N P=0.503N | P=0.299 P=0.146 P=0.124 P=0.525 |
|COCHRAN-ARMITAGE | P=0.407N | P=0.439N |
|FISHER EXACT | P=0.510N P=0.510N P=0.505N | P=0.357 P=0.631 P=0.631N |
|=================================================================================================================================|
| |
|Skin |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 4/50 (8%) 1/50 (2%) 7/50 (14%) | 2/50 (4%) 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 3.7% 12.3% 3.4% 31.5% | 5.0% 2.2% 5.8% 3.0% |
|TERMINAL (d) | 1/27 (4%) 1/27 (4%) 0/14 (0%) 2/13 (15%) | 1/35 (3%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 659 649 454 | 541 482 440 538 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** P=0.183 P=0.659 P=0.005 ** | P=0.599 P=0.605N P=0.401 P=0.712 |
|INCIDENTAL TUMOR | P=0.029 * P=0.158 P=0.741 P=0.035 * | P=0.287N P=0.547N P=0.509N P=0.468N |
|LOGISTIC REGRESSION | P=0.017 * P=0.172 P=0.731 P=0.033 * | P=0.340N P=0.458N P=0.584N P=0.457N |
|COCHRAN-ARMITAGE | P=0.022 * | P=0.465N |
|FISHER EXACT | P=0.181 P=0.753N P=0.030 * | P=0.500N P=0.691N P=0.500N |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 11/50 (22%) 11/50 (22%) 18/50 (36%) |
|ADJUSTED (b) | 0.0% 0.0% 2.8% 0.0% | 0.0% 35.3% 100.0% 69.6% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 0/13 (0%) | 0/35 (0%) 2/16 (13%) 1/1 (100%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 607 --- | --- 285 524 462 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.763 (e) P=0.465 (e) | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.722N (e) P=0.548 (e) | P=0.004 ** P=0.008 ** P=0.007 ** P=0.009 ** |
|LOGISTIC REGRESSION | P=0.759N (e) P=0.579 (e) | P<0.001 ** P=0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.778 | P<0.001 ** |
|FISHER EXACT | (e) P=0.500 (e) | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/49 (4%) 2/50 (4%) 1/50 (2%) | 1/50 (2%) 1/49 (2%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 7.4% 8.5% 2.6% | 2.9% 2.2% 3.6% 0.0% |
|TERMINAL (d) | 0/27 (0%) 2/27 (7%) 0/14 (0%) 0/13 (0%) | 1/35 (3%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 607 603 | 734 (T) 482 551 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.382 P=0.238 P=0.159 P=0.471 | P=0.532N P=0.669 P=0.436 P=0.941N |
|INCIDENTAL TUMOR | P=0.564 P=0.238 P=0.313 P=0.587 | P=0.281N P=0.701 P=0.840 P=0.941N |
|LOGISTIC REGRESSION | P=0.536 P=0.238 P=0.239 P=0.583 | P=0.271N P=0.750N P=0.760 P=0.941N |
|COCHRAN-ARMITAGE | P=0.564 | P=0.316N |
|FISHER EXACT | P=0.242 P=0.247 P=0.500 | P=0.747 P=0.747 P=0.500N |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) 5/50 (10%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 4/50 (8%) |
|ADJUSTED (b) | 3.7% 0.0% 14.3% 15.3% | 2.9% 0.0% 0.0% 18.8% |
|TERMINAL (d) | 1/27 (4%) 0/27 (0%) 2/14 (14%) 0/13 (0%) | 1/35 (3%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- 733 (T) 587 | 734 (T) --- --- 576 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** P=0.500N P=0.276 P=0.052 | P<0.001 ** P=0.656N P=0.998N P=0.015 * |
|INCIDENTAL TUMOR | P=0.013 * P=0.500N P=0.276 P=0.158 | P=0.037 * P=0.656N P=0.998N P=0.533 |
|LOGISTIC REGRESSION | P=0.010 * P=0.500N P=0.276 P=0.132 | P=0.007 ** P=0.656N P=0.998N P=0.120 |
|COCHRAN-ARMITAGE | P=0.012 * | P=0.018 * |
|FISHER EXACT | P=0.500N P=0.500 P=0.102 | P=0.500N P=0.500N P=0.181 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 4/50 (8%) |
|ADJUSTED (b) | 3.7% 0.0% 14.3% 12.7% | 0.0% 0.0% 0.0% 18.8% |
|TERMINAL (d) | 1/27 (4%) 0/27 (0%) 2/14 (14%) 0/13 (0%) | 0/35 (0%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- 733 (T) 587 | --- --- --- 576 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.009 ** P=0.500N P=0.276 P=0.099 | P<0.001 ** (e) (e) P=0.010 ** |
|INCIDENTAL TUMOR | P=0.032 * P=0.500N P=0.276 P=0.238 | P=0.021 * (e) (e) P=0.486 |
|LOGISTIC REGRESSION | P=0.030 * P=0.500N P=0.276 P=0.216 | P=0.001 ** (e) (e) P=0.053 |
|COCHRAN-ARMITAGE | P=0.037 * | P=0.002 ** |
|FISHER EXACT | P=0.500N P=0.500 P=0.181 | (e) (e) P=0.059 |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/49 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 2/49 (4%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 11.5% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 0/13 (0%) | 0/35 (0%) 1/16 (6%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 719 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.729 P=0.099 (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.617N P=0.233 (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.780 P=0.131 (e) (e) |
|COCHRAN-ARMITAGE | (e) | P=0.381N |
|FISHER EXACT | (e) (e) (e) | P=0.242 (e) (e) |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/49 (2%) 1/50 (2%) 1/50 (2%) | 1/50 (2%) 3/49 (6%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 3.4% 3.7% 3.7% 7.7% | 2.9% 14.3% 12.5% 0.0% |
|TERMINAL (d) | 0/27 (0%) 1/27 (4%) 0/14 (0%) 1/13 (8%) | 1/35 (3%) 1/16 (6%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | 729 733 (T) 666 733 (T) | 734 (T) 673 656 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.436 P=0.752 P=0.645 P=0.581 | P=0.566 P=0.121 P=0.222 P=0.941N |
|INCIDENTAL TUMOR | P=0.620 P=0.749 P=0.671N P=0.735 | P=0.391N P=0.311 P=0.598 P=0.941N |
|LOGISTIC REGRESSION | P=0.515 P=0.753 P=0.720 P=0.582 | P=0.535N P=0.197 P=0.543 P=0.941N |
|COCHRAN-ARMITAGE | P=0.653N | P=0.179N |
|FISHER EXACT | P=0.747 P=0.753N P=0.753N | P=0.301 P=0.747 P=0.500N |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | | 0.0% 0.0% 0.0% 9.3% |
|TERMINAL (d) | | 0/35 (0%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | | --- --- --- 624 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.014 * (e) (e) P=0.102 |
|INCIDENTAL TUMOR | | P=0.133 (e) (e) P=0.696 |
|LOGISTIC REGRESSION | | P=0.027 * (e) (e) P=0.206 |
|COCHRAN-ARMITAGE | | P=0.043 * |
|FISHER EXACT | | (e) (e) P=0.247 |
|=================================================================================================================================|
| |
|Uterus |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | | 0.0% 0.0% 7.6% 0.0% |
|TERMINAL (d) | | 0/35 (0%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | | --- --- 515 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.626 (e) P=0.135 (e) |
|INCIDENTAL TUMOR | | P=0.520N (e) P=0.616 (e) |
|LOGISTIC REGRESSION | | P=0.679N (e) P=0.303 (e) |
|COCHRAN-ARMITAGE | | P=0.700 |
|FISHER EXACT | | (e) P=0.247 (e) |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 4/50 (8%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | | 5.7% 17.7% 6.7% 23.2% |
|TERMINAL (d) | | 2/35 (6%) 2/16 (13%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | | 734 (T) 551 537 443 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.037 * P=0.118 P=0.187 P=0.037 * |
|INCIDENTAL TUMOR | | P=0.349 P=0.243 P=0.643 P=0.323 |
|LOGISTIC REGRESSION | | P=0.438 P=0.270 P=0.668 P=0.417 |
|COCHRAN-ARMITAGE | | P=0.549 |
|FISHER EXACT | | P=0.339 P=0.691N P=0.500 |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 10.8% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/14 (0%) 0/13 (0%) | 0/35 (0%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- --- 565 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.004 ** (e) (e) P=0.054 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.053 (e) (e) P=0.577 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.009 ** (e) (e) P=0.137 |
|COCHRAN-ARMITAGE | (e) | P=0.010 ** |
|FISHER EXACT | (e) (e) (e) | (e) (e) P=0.121 |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 3.7% 7.2% 12.6% | 0.0% 0.0% 100.0% 39.5% |
|TERMINAL (d) | 0/27 (0%) 1/27 (4%) 0/14 (0%) 1/13 (8%) | 0/35 (0%) 0/16 (0%) 1/1 (100%) 1/3 (33%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 607 677 | --- --- 607 624 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.073 P=0.500 P=0.185 P=0.112 | P<0.001 ** (e) P=0.010 * P=0.007 ** |
|INCIDENTAL TUMOR | P=0.194 P=0.500 P=0.313 P=0.198 | P=0.012 * (e) P=0.056 P=0.102 |
|LOGISTIC REGRESSION | P=0.152 P=0.500 P=0.256 P=0.154 | P=0.004 ** (e) P=0.072 P=0.037 * |
|COCHRAN-ARMITAGE | P=0.199 | P=0.032 * |
|FISHER EXACT | P=0.500 P=0.247 P=0.247 | (e) P=0.247 P=0.121 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 13/50 (26%) 22/50 (44%) 19/50 (38%) | 4/50 (8%) 6/50 (12%) 17/50 (34%) 5/50 (10%) |
|ADJUSTED (b) | 11.1% 38.6% 69.8% 68.0% | 10.6% 25.7% 100.0% 18.3% |
|TERMINAL (d) | 3/27 (11%) 7/27 (26%) 6/14 (43%) 6/13 (46%) | 3/35 (9%) 2/16 (13%) 1/1 (100%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 659 495 454 | 541 482 216 523 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.009 ** P<0.001 ** P<0.001 ** | P=0.017 * P=0.104 P<0.001 ** P=0.061 |
|INCIDENTAL TUMOR | P<0.001 ** P=0.004 ** P<0.001 ** P<0.001 ** | P=0.301N P=0.310 P=0.029 * P=0.669N |
|LOGISTIC REGRESSION | P<0.001 ** P=0.006 ** P<0.001 ** P<0.001 ** | P=0.493N P=0.330 P=0.009 ** P=0.486 |
|COCHRAN-ARMITAGE | P=0.001 ** | P=0.504 |
|FISHER EXACT | P=0.006 ** P<0.001 ** P<0.001 ** | P=0.370 P=0.001 ** P=0.500 |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 14/50 (28%) 23/50 (46%) 21/50 (42%) | 4/50 (8%) 6/50 (12%) 18/50 (36%) 8/50 (16%) |
|ADJUSTED (b) | 11.1% 41.7% 70.7% 74.1% | 10.6% 25.7% 100.0% 50.8% |
|TERMINAL (d) | 3/27 (11%) 8/27 (30%) 6/14 (43%) 7/13 (54%) | 3/35 (9%) 2/16 (13%) 1/1 (100%) 1/3 (33%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 659 495 454 | 541 482 216 523 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.005 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.104 P<0.001 ** P=0.002 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.002 ** P<0.001 ** P<0.001 ** | P=0.482 P=0.310 P=0.024 * P=0.288 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.003 ** P<0.001 ** P<0.001 ** | P=0.248 P=0.330 P=0.005 ** P=0.110 |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.189 |
|FISHER EXACT | P=0.003 ** P<0.001 ** P<0.001 ** | P=0.370 P<0.001 ** P=0.178 |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 2/50 (4%) 1/50 (2%) | 1/50 (2%) 2/50 (4%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 8.5% 0.0% 6.4% 4.0% | 2.4% 6.9% 6.7% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/27 (0%) 0/14 (0%) 0/13 (0%) | 0/35 (0%) 0/16 (0%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | 603 --- 607 656 | 637 551 378 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.556N P=0.130N P=0.640N P=0.480N | P=0.508N P=0.392 P=0.180 P=0.733N |
|INCIDENTAL TUMOR | P=0.299N P=0.136N P=0.440N P=0.255N | P=0.079N P=0.633N P=0.627N P=0.136N |
|LOGISTIC REGRESSION | P=0.370N P=0.116N P=0.463N P=0.290N | P=0.169N P=0.528 P=0.492 P=0.521N |
|COCHRAN-ARMITAGE | P=0.397N | P=0.285N |
|FISHER EXACT | P=0.121N P=0.500N P=0.309N | P=0.500 P=0.309 P=0.500N |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 2/50 (4%) 4/50 (8%) | 7/50 (14%) 7/50 (14%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 6.5% 7.4% 14.3% 15.6% | 18.0% 26.9% 22.3% 10.0% |
|TERMINAL (d) | 1/27 (4%) 2/27 (7%) 2/14 (14%) 1/13 (8%) | 5/35 (14%) 2/16 (13%) 0/1 (0%) 0/3 (0%) |
|FIRST INCIDENCE (DAYS) | 680 733 (T) 733 (T) 603 | 35 548 539 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.057 P=0.694 P=0.469 P=0.166 | P=0.539N P=0.234 P=0.216 P=0.606N |
|INCIDENTAL TUMOR | P=0.128 P=0.685 P=0.553 P=0.354 | P=0.035N* P=0.526N P=0.438N P=0.177N |
|LOGISTIC REGRESSION | P=0.133 P=0.683 P=0.538 P=0.329 | P=0.020N* P=0.579N P=0.103N P=0.021N* |
|COCHRAN-ARMITAGE | P=0.216 | P=0.014N* |
|FISHER EXACT | P=0.691N P=0.691N P=0.339 | P=0.613N P=0.159N P=0.030N* |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 31/50 (62%) 31/50 (62%) 38/50 (76%) 43/50 (86%) | 22/50 (44%) 32/50 (64%) 38/50 (76%) 42/50 (84%) |
|ADJUSTED (b) | 79.3% 78.8% 91.9% 97.5% | 57.8% 87.7% 100.0% 100.0% |
|TERMINAL (d) | 19/27 (70%) 19/27 (70%) 11/14 (79%) 12/13 (92%) | 19/35 (54%) 12/16 (75%) 1/1 (100%) 3/3 (100%) |
|FIRST INCIDENCE (DAYS) | 596 439 382 392 | 637 447 346 383 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.540 P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.547 P=0.053 P<0.001 ** | P<0.001 ** P=0.009 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.532 P=0.026 * P<0.001 ** | P<0.001 ** P=0.003 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.002 ** | P<0.001 ** |
|FISHER EXACT | P=0.582N P=0.097 P=0.006 ** | P=0.035 * P=0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 34/50 (68%) 40/50 (80%) 50/50 (100%) 47/50 (94%) | 20/50 (40%) 42/50 (84%) 49/50 (98%) 48/50 (96%) |
|ADJUSTED (b) | 71.4% 83.2% 100.0% 97.9% | 44.8% 89.3% 100.0% 100.0% |
|TERMINAL (d) | 14/27 (52%) 19/27 (70%) 14/14 (100%) 12/13 (92%) | 11/35 (31%) 11/16 (69%) 1/1 (100%) 3/3 (100%) |
|FIRST INCIDENCE (DAYS) | 452 523 382 392 | 35 285 216 324 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.223 P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.004 ** P=0.111 P<0.001 ** P=0.011 * | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.004 ** P=0.126 P<0.001 ** P=0.014 * | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.127 P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 48/50 (96%) 50/50 (100%) 50/50 (100%)| 34/50 (68%) 47/50 (94%) 50/50 (100%) 48/50 (96%) |
|ADJUSTED (b) | 96.0% 97.9% 100.0% 100.0% | 77.0% 97.9% 100.0% 100.0% |
|TERMINAL (d) | 25/27 (93%) 26/27 (96%) 14/14 (100%) 13/13 (100%)| 25/35 (71%) 15/16 (94%) 1/1 (100%) 3/3 (100%) |
|FIRST INCIDENCE (DAYS) | 452 439 382 392 | 35 285 216 324 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.518 P=0.002 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.164 P=0.685N P=0.391 P=0.409 | P=0.004 ** P=0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.171 P=0.684N P=0.391 P=0.409 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.106 | P<0.001 ** |
|FISHER EXACT | P=0.691N P=0.247 P=0.247 | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).