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TDMS Study 05136-08 Pathology Tables

NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04

                                                           CORE STUDY




       Facility:  Battelle Northwest

       Chemical CAS #:  0000126-99-8

       Lock Date:  04/14/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1

NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3|             
                                           | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |             4                                                            |             
      Inflammation, Suppurative            |                                                    1           2         |             
      Necrosis                             |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
      Peyer's Patch, Hyperplasia           |                   2                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              4                           |             
      Basophilic Focus                     |                         X        X  4                 X                  |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |                                                    1                     |             
      Eosinophilic Focus                   | X  X  X                       X  X        X                    X        X|             
      Fibrosis                             |             2                                                            |             
      Hematopoietic Cell Proliferation     |                            1                                             |             
      Necrosis                             |                                  2        1                              |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |                                  2                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +        +              +     +  +                           |             
      Angiectasis                          |                                                                          |             
      Fat, Necrosis                        |       3     2        3                    3                              |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                               +                                          |             
      Pharyngeal, Hyperplasia              |                               4                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Atrophy                              |       1                                                                  |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       1                                                                  |             
      Mineralization                       |       2                                                                  |             
      Epithelium, Hyperplasia              |                                           1                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +                                                                  |             
      Hyperplasia                          |       1                                                                  |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3|             
                                           | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1  1  1  1  1     1  1  1           1  1  1  1     1  1      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                1         |             
      Hypertrophy                          |                         1     1                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                       1        1                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |       3                       2     2  2     1  2  4           2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    3     4                                1  1  1  2                    1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  M  +  M  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         1        2  3                                    |             
      Cyst                                 | 4        2  1              2  2        2     2  3  1           3  3      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                    2               |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |          4                                2        3  2                  |             
      Inflammation, Suppurative            |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                             |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +                                             |             
      Iliac, Hyperplasia                   |                            2                                             |             
      Pancreatic, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  M  +  M  M  M  M  +  +|             
      Hyperplasia                          |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  M  +  +  +  M  M  M  +  +  +  M  +  M  M  M  +  M  +  M  +  +|             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3|             
                                           | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                             4            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       3     2                                4                 2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  3           2        3        2                                    |             
      Hyperplasia, Lymphoid                |                                     2  2  3  2        2        2  2      |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Angiectasis                          |                                        2                                 |             
      Atrophy                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    1        2                       2  3           2  2  2  1           1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                                      2   |             
      Meninges, Inflammation, Chronic      |             3                             1                              |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   1                                                      |             
      Perivascular, Infiltration Cellular  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |                1     1  1                                                |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3|             
                                           | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Hyaline                         |                                                                          |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Adenomatous                     |                1        1                                                |             
      Olfactory Epithelium, Metaplasia     |                1        1                                                |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 1  1  1        1     1     1           1        1     1        1     1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nephropathy                          | 1  1  1     1  1  1     1  1  1  1  1     1     1  1  1  1  1  1  1  1  1|             
      Artery, Inflammation, Chronic        |             3                                                            |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Angiectasis                          |          2                                                               |      1  2.0|
      Cyst                                 |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                    1                     |      3  1.3|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                 2                        |      1  2.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                2                                                         |      2  3.0|
      Basophilic Focus                     |                                                                          |      4  4.0|
      Clear Cell Focus                     |                      2                                                   |      1  2.0|
      Degeneration, Fatty                  |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                   X     X     X                          X     4         |     13  4.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Necrosis                             | 1                                                                    1   |      4  1.3|
      Bile Duct, Cyst                      |                                        2                                 |      1  2.0|
      Bile Duct, Hyperplasia               |          1                                                               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                    +  +                 +                     |  10        |
      Angiectasis                          |          1                                                               |      1  1.0|
      Fat, Necrosis                        |                               3  2                 3                     |      7  2.7|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Pharyngeal, Hyperplasia              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                   1                                      1               |      3  1.0|
      Hypertrophy                          | 1                                                                 1      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                      1                                                   |      2  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              | 4                    1                          2                        |      4  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                     |   2        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation                         |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1  1        1  1  1     1  1  1           1  1  1     1  1     1  1|     35  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                            2                                             |      1  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Hypertrophy                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  +  M  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  M  +  M|  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           |       2        2     2              2  1  1              1  2  2     1   |     18  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |                1  1                                   2              1  2|     12  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                               2  3        2                       2      |      7  2.1|
      Cyst                                 |                2  1        2  2     1  2           2     2     2         |     20  2.1|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |          2                                                               |      3  2.0|
      Hemorrhage                           |          2                                                               |      1  2.0|
      Hydrometra                           |                                                          3           2  2|      3  2.3|
      Hyperplasia, Cystic                  |                         3                                                |      5  2.8|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                      3                                                   |      2  3.0|
      Necrosis                             |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                         +           +         |   4        |
      Iliac, Hyperplasia                   |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia              |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  +  +  M  +  +  +  I  +  +  M  +  M  +  +  +  +  +  +  M  M  M  +|  32        |
      Hyperplasia                          |                                                    3                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  I  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  M  +  +  +  M  M  +|  32        |
      Hyperplasia                          |                                        2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |          2                                                               |      1  2.0|
      Hyperplasia                          |    2                                                                 2   |      6  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  M  M  +  M  +  +  M  +  +  +  +  +  +  M  +|  38        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                           1                              |      1  1.0|
      Hematopoietic Cell Proliferation     |          3           2     4  2                    2        3     2  2   |     13  2.5|
      Hyperplasia, Lymphoid                |    2                                   2                                 |      9  2.1|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|  44        |
      Angiectasis                          |                                                                          |      1  2.0|
      Atrophy                              |                                              2                           |      1  2.0|
      Hyperplasia, Lymphoid                |                                                    2                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                3                                                         |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                      3                       2                           |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 3     2     1           1                                2  1            |     15  1.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gliosis                              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Meninges, Inflammation, Chronic      |             1                                                            |      3  1.7|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |   1        |
      Degeneration                         | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |                   3                                                      |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Perivascular, Infiltration Cellular  |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Olfactory Epithelium, Atrophy        |                   2                    1                       1         |      6  1.2|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |       1                                   1                             1|      3  1.0|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Adenomatous                     |                                                                          |      2  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      2  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |       1  1                                1        1           1        1|     17  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |          3                                                               |      1  3.0|
      Inflammation, Chronic Active         |                      1                                                   |      1  1.0|
      Nephropathy                          | 1  1  1  2     1  1  1  1     2  1     1  1     1  1  1  1     1  1  1  1|     41  1.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
      Renal Tubule, Mineralization         |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3|             
                                           | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                   1      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Suppurative            |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +|             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                4                                                         |             
      Eosinophilic Focus                   | X                 X  X           X                       X               |             
      Hematopoietic Cell Proliferation     |                2     1        2                    1                     |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                              1                 2         |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Necrosis              |                                     3                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +        +        +  +  +     +                           |             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Necrosis                        |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                 1                             1                        |             
      Hypertrophy                          |                                                                      1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                              X                           |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     1  1  1  1  1  1  1     1     1  1     1     1        1     1   |             
      Atrium, Thrombosis                   |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                         1                                                |             
      Capsule, Hyperplasia                 |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3|             
                                           | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2           2                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  M  +  M  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |                   4        3           4              2                 1|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |          1  2        1           1     2        2                 1     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  M  M  +  +  +  +  M  +  +  +  +  M  +  +  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                     2  2                                 |             
      Cyst                                 |    1           2                                   1     2        4      |             
      Hemorrhage                           |                                                                          |             
      Granulosa Cell, Hyperplasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |    3                 4  2                       4                        |             
      Hyperplasia, Cystic                  |             2                                            3               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +           +                 +         |             
      Renal, Hyperplasia                   |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  M  +  +  M  +  +  +  +  +  +  +  +  M  M  M  +  +  +  M  +  +  +|             
      Congestion                           |                                     2                                    |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Hyperplasia                          |                      2  2              3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  M  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                    2                     |             
      Infiltration Cellular, Mast Cell     |             4                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |             4                 2                                          |             
      Hyperplasia                          |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3|             
                                           | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                 3                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2        2     4     1     1  4     3     4  2     2  2     3  2         |             
      Hyperplasia, Lymphoid                |    2                    2                       2              2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                1  1                             2                    1   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  1                                       |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                2  2        3           4              1  2        2      |             
      Thrombosis                           |                                                                2         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Bronchiole, Hyperplasia              |          2              1  2  1  1  2  3                    2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |             2                                                            |             
      Inflammation, Suppurative            |                                  1                                       |             
      Olfactory Epithelium, Atrophy        |                   1                                                      |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Adenomatous                     |                   1                                                      |             
      Olfactory Epithelium, Metaplasia     |                   1                                                      |             
      Olfactory Epithelium, Glands,        |                                                                          |             
          Inflammation, Acute              |                                                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    1              2                    1  1                    2  1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6|             
                             DAY ON TEST   | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3|             
                                           | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Inflammation                         |                            4                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                         +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Metaplasia, Osseous                  |                                                       1                  |             
      Nephropathy                          | 1        1  1  1  1  1  1  1     1  1  1  1  1  1     1  1     1  1     1|             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2|            |
                                           | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  44        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Inflammation, Suppurative            |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
      Lymphoid Tissue, Hyperplasia         |                                                                      1   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Angiectasis                          |                                                                4  2      |      3  3.3|
      Eosinophilic Focus                   |                   X  X           X     X     X     X              X      |     12     |
      Hematopoietic Cell Proliferation     |                                                                   2      |      5  1.6|
      Inflammation, Chronic                |                                              3                           |      1  3.0|
      Necrosis                             |             1     2                          4                           |      5  2.0|
      Vacuolization Cytoplasmic            |                                                 2              3         |      2  2.5|
      Bile Duct, Hyperplasia               |                                                                   1      |      1  1.0|
      Centrilobular, Necrosis              |                                                       2                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +           +     +                    +        +        +  +      |  14        |
      Fat, Inflammation, Chronic           |                                                                2         |      1  2.0|
      Fat, Necrosis                        |                                                       2           2      |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Atrophy                              |                   1  1                    1                              |      6  1.0|
      Hypertrophy                          |          1                                                  1            |      3  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Inflammation                         |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Diverticulum                         |                X                                                         |      2     |
      Ulcer                                |    2                                                  2                  |      2  2.0|
      Epithelium, Hyperplasia              | 3                 4                                   4                  |      3  3.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Cardiomyopathy                       |       1  1  1  1  1  1  1  1  1  1  1  1  1  1  2        1     1  1  1   |     35  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2|            |
                                           | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Hypertrophy                          |                                     2                                    |      2  1.5|
      Capsule, Hyperplasia                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  M  M  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  M  +  M|  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Pars Distalis, Angiectasis           |                                                          1               |      1  1.0|
      Pars Distalis, Hyperplasia           |                      1        1     1                                    |      8  2.1|
      Pars Intermedia, Hyperplasia         |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Follicular Cell, Hyperplasia         |          3     1        2     2     1  1           2                     |     15  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  A|  40        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Angiectasis                          |                                                                      2   |      1  2.0|
      Atrophy                              | 3     2  2                             3              2     3            |      8  2.4|
      Cyst                                 | 4        1     1  2     4     2  1     3     1  3  2        1  3         |     18  2.1|
      Hemorrhage                           |                      3                                                   |      1  3.0|
      Granulosa Cell, Hyperplasia          | 2                                            2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hydrometra                           |                                                             4  4         |      6  3.5|
      Hyperplasia, Cystic                  |                               2                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Atrophy                              |                                                                4         |      1  4.0|
      Hyperplasia                          |    2                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Renal, Hyperplasia                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  +  +  M  +  +  +  M  +  M  +  +  +  M  +  +  +  M  M  M  +  +  A|  31        |
      Congestion                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2|            |
                                           | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  A|  40        |
      Angiectasis                          |                                                          3               |      1  3.0|
      Hyperplasia                          |                                                                   2      |      2  2.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  A|  45        |
      Angiectasis                          |                                     2                                    |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|  44        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hematopoietic Cell Proliferation     |    2  2  2        3     3     1              2  2     3  3     2  2      |     25  2.4|
      Hyperplasia, Lymphoid                |                            2                                             |      5  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M  M  +  +  +  +  +  +  +  M  +  +  +  M  M  +  M  M  +  +  +  M  M|  35        |
      Angiectasis                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Inflammation, Chronic Active         |          4                                      4                        |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Fibrous Osteodystrophy               | 2        1           2        1        1           2     1               |     11  1.4|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hemorrhage                           |             4                                                            |      1  4.0|
      Infiltration Cellular, Histiocyte    |                         1  2  1  1        1        2        4            |     14  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2|            |
                                           | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                               2                                          |      1  2.0|
      Bronchiole, Hyperplasia              |                3                 2  2                    2  2  4  1      |     15  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Olfactory Epithelium, Atrophy        |                                           1              1  2     1      |      5  1.2|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Adenomatous                     |                                           1                       1      |      3  1.0|
      Olfactory Epithelium, Metaplasia     |                                           1                       1      |      3  1.0|
      Olfactory Epithelium, Glands,        |                                                                          |            |
          Inflammation, Acute              |                                                             2            |      1  2.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |          1        1                                      1               |      9  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +           +                          +     +      |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hydronephrosis                       |    2                                                                     |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy                          | 1     1  1           1  1  1  1  1  1  1  1     1        1  1     1  1   |     35  1.0|
      Pigmentation, Hemosiderin            |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0|             
                                           | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  A  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +|             
      Degeneration, Hyaline                |                                     2                                    |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia         |                1                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
      Peyer's Patch, Hyperplasia           | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            4           2                       3         |             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |                         X  X     X              X        X     X        X|             
      Hematopoietic Cell Proliferation     | 1                                2                    1                  |             
      Mineralization                       |                                                                          |             
      Necrosis                             |    2           2  2        1              1                 1        3   |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Degeneration          |       1                                                                  |             
      Centrilobular, Necrosis              |                                                          2        1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +     +  +     +  +           +  +  +  +  +     +  +     +     +|             
      Hemorrhage                           |                                                          2               |             
      Fat, Necrosis                        |                                                                         3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      1              1              1                     |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                       1              1   |             
      Epithelium, Hyperplasia              |             2              2                          3  1           2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                              2           2              2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1  1     1  1  1  1     1     1  1     1  1     1  1     1     1  1|             
      Mineralization                       |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hypertrophy                          | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0|             
                                           | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Inflammation, Focal, Granulomatous   | 1                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  +  +  +  +  M  +  M  +  M  +  M  +  +  +  M  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |       3           3                             2                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                  1     2     1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  M  +  M  +  M  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Atrophy                              | 2                 1                    2     3        2                  |             
      Cyst                                 |                            2     4                    3                  |             
      Granulosa Cell, Hyperplasia          |                                                                2         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        4                                 |             
      Hydrometra                           |                      3                                                   |             
      Hyperplasia, Cystic                  |                   2                                                      |             
      Inflammation, Suppurative            |                               4                                         2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                                                               |             
      Hyperplasia                          |                                                                          |             
      Iliac, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  M  M  +  +  M  +  M  M  +  M  +  M  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                               2                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  I  +  +  +  M  +  M  +  M  M  M  I  M  +  M  +  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   2                                                      |             
      Hyperplasia                          |                         3                       3                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0|             
                                           | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 4  3  4     3  3  4  2  2  2  3  3  2  2  2  3  2  3  2  4  4  2  4  2  3|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +|             
      Atrophy                              |                                                       2              3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                               3        2     1                           |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                                                               |             
      Inflammation, Suppurative            |                                                                      1   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          4               |             
      Infiltration Cellular, Histiocyte    | 2                    2  3           2  3     2  2  2     3               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Bronchiole, Hyperplasia              |    2        3              1  2                 1     2              2  2|             
      Perivascular, Infiltration Cellular  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                        1                                 |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 1                                1           1              1            |             
      Respiratory Epithelium, Necrosis     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                     +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0|             
                                           | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                 2                        |             
      Nephropathy                          | 1     1        2  1     1     1     1     1  1  1           1        1   |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Necrosis               |                2                                         3        3      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6|            |
                             DAY ON TEST   | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5|            |
                                           | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +|  42        |
      Degeneration, Hyaline                |                                                    2                     |      2  2.0|
      Inflammation, Suppurative            |                               1  2                                       |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  45        |
      Lymphoid Tissue, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  44        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 2                                                                        |      4  2.8|
      Degeneration, Fatty                  | 2              2                                                         |      2  2.0|
      Eosinophilic Focus                   | X     X                 X  X  X                    X  X              X   |     15     |
      Hematopoietic Cell Proliferation     |       1              2        2           2     1           2            |      9  1.6|
      Mineralization                       |                               2                                          |      1  2.0|
      Necrosis                             | 2                       2  1  3           1                    2         |     13  1.8|
      Bile Duct, Hyperplasia               |                                  1                                       |      1  1.0|
      Centrilobular, Degeneration          |                            2                                             |      2  1.5|
      Centrilobular, Necrosis              |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +     +                 +  +  +  +  +        +           +  +     +   |  27        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Fat, Necrosis                        |                               2                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +|  48        |
      Atrophy                              |                1        3                                                |      5  1.4|
      Hypertrophy                          |                1                          1           1                  |      3  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Ulcer                                |                            1                                             |      3  1.0|
      Epithelium, Hyperplasia              |                         1           1                 1                  |      8  1.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Necrosis                             |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1     1        1  2  1  1     2  2  1     2  1  1     1     1  1  1  2   |     34  1.1|
      Mineralization                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6|            |
                             DAY ON TEST   | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5|            |
                                           | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Hematopoietic Cell Proliferation     |       2                       2                                          |      2  2.0|
      Hypertrophy                          |                            1        1                                    |      3  1.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +|  48        |
      Hyperplasia                          |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  I  M  I  +  +  +  +  M  +  M  +  +  M  M  +  +  M  +  +  M  +  M|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                               4                                          |      1  4.0|
      Pars Distalis, Hyperplasia           | 4              1     1        4                                          |      7  2.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Follicular Cell, Hyperplasia         | 3              2                    3                       1           2|      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  M  +  +  M  +  M  M  +  +  M  +  +  +  M  +  +  +  M  M  +  +  +  +  M|  32        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      Atrophy                              |       4                 1                                                |      7  2.1|
      Cyst                                 |                                              2                          1|      5  2.4|
      Granulosa Cell, Hyperplasia          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                      2                                                   |      2  3.0|
      Hydrometra                           |                                                    4                     |      2  3.5|
      Hyperplasia, Cystic                  |                                           1                              |      2  1.5|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Hyperplasia                          |                                                 2           2            |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                          +                 +                    +   |   5        |
      Hyperplasia                          |                                                 3                        |      1  3.0|
      Iliac, Hyperplasia                   |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  M  +  +  +  +  M  +  +  +  M  M  +  +  M  +  M  +  +  M  +  +|  34        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6|            |
                             DAY ON TEST   | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5|            |
                                           | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                               3                                          |      1  3.0|
      Hyperplasia                          |                         2           2                                    |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  M  +  M  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Angiectasis                          |                                                 2                        |      1  2.0|
      Hyperplasia                          |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +|  45        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |             3                 3     2  2     2                           |      7  2.6|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Hematopoietic Cell Proliferation     | 2  4  3     2  2     3  3  3  4     2  4  4     2     2  4  2  3        2|     42  2.8|
      Hyperplasia, Lymphoid                |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  M  +  M  M  M  M  +  +  M  +  +  +  +  +  A  +  +|  39        |
      Atrophy                              |                            2                                             |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                2                 2              1                        |      6  1.8|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                +         |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Infiltration Cellular, Histiocyte    | 3  2                    4     1              3     3        1        2  2|     18  2.3|
      Alveolar Epithelium, Hyperplasia     | 3                                                                        |      1  3.0|
      Bronchiole, Hyperplasia              |       3                    4  2        2                                 |     12  2.2|
      Perivascular, Infiltration Cellular  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6|            |
                             DAY ON TEST   | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5|            |
                                           | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Inflammation, Suppurative            | 3                                            1     1                     |      3  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             1                                                            |      1  1.0|
      Olfactory Epithelium, Atrophy        | 1                                            1     2                     |      4  1.3|
      Olfactory Epithelium, Metaplasia     |                                                    2                     |      1  2.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 2        2        1        1                 2                 1         |     10  1.3|
      Respiratory Epithelium, Necrosis     | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                   +                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Hydronephrosis                       |                                  4  3                    4               |      4  3.3|
      Nephropathy                          | 1              1     1     1  1  2  1  1        1     1     1        1  1|     25  1.1|
      Papilla, Necrosis                    |                                  2                                       |      1  2.0|
      Renal Tubule, Necrosis               |                            3                                             |      4  2.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +|  46        |
      Hemorrhage                           |                                        2                                 |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3|             
                             DAY ON TEST   | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2|             
                                           | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  A|             
      Inflammation, Suppurative            |                                                          1               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Epithelium, Hyperplasia              |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   4                                                      |             
      Basophilic Focus                     |                         X                                                |             
      Eosinophilic Focus                   |          X     X  X        X        X     X        X  X  X     X  X  X  X|             
      Hematopoietic Cell Proliferation     |       1                                2  1  1                 1        2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                1           2                       2                    2|             
      Regeneration                         |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |                                        2                             1  1|             
      Centrilobular, Degeneration          |                2                                                         |             
      Centrilobular, Necrosis              |                                                 2           2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +     +        +     +           +           +  +     +  +            |             
      Angiectasis                          |                                                                          |             
      Fat, Necrosis                        |    2     2        4     3           2           3        3  2            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |          1                                                     1         |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                1         |             
      Duct, Cyst                           |                                                          4               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      4           3        4                              |             
      Inflammation, Suppurative            |          2           2                                1                  |             
      Ulcer                                |                               2  1                                       |             
      Epithelium, Hyperplasia              |       2        2  2           2  3        3  2  2     4  2     2  4     2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Hyaline                |                                                                          |             
      Inflammation, Suppurative            |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3|             
                             DAY ON TEST   | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2|             
                                           | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1     1  1  1  1              1  1  1  1  2  1  1  1  1  1  1  1   |             
      Artery, Inflammation                 |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                        1                                 |             
      Hypertrophy                          |                   2                                                      |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                  1              1                        |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                           2              1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2                    2                             2   |             
      Cyst                                 |                                  2                                       |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Corpus Luteum, Hyperplasia           |                                                       4                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                         2                                                |             
      Hydrometra                           |                      4                                3           2     4|             
      Hyperplasia, Cystic                  |                4                                                     3   |             
      Endometrium, Hyperplasia             |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3|             
                             DAY ON TEST   | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2|             
                                           | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                2                                                         |             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                           +        +                     |             
      Iliac, Hyperplasia                   |                                           4                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  M  +  M  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  M  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2                                         4     4     3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Hyperplasia                          |                      2           2     3  3                       2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  4  4  3  4        3  3        2  4  3  4  4  3     2  4  2  3  2  4|             
      Hyperplasia, Lymphoid                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  +  +  I  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |    2                                      2                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sebaceous Gland, Hyperplasia         |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    2                    1        4                 1  1  1               |             
      Fracture                             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Inflammation, Chronic      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                         1                 1            |             
      Inflammation, Suppurative            | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3|             
                             DAY ON TEST   | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2|             
                                           | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Epiglottis, Hyperplasia              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                     1                                    |             
      Infiltration Cellular, Histiocyte    |          3     2     3     2     4  2                 2              2  3|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    2                    1           2                                    |             
      Bronchiole, Hyperplasia              |    3     2     3  3  2     2  1  2     2     3        4  2  2        2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                          2               |             
      Metaplasia                           |                                        1                                 |             
      Olfactory Epithelium, Atrophy        | 2  3  2  2  2  3  3  2  2  2     2  3  2  2  2  1  2  3  2  2  2  2  2  1|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Adenomatous                     | 1  2  2  2  1  2  2  2  2  2     2  2  2  2     1  2  2  2  2  2  2  2  2|             
      Olfactory Epithelium, Metaplasia     | 2  3  2  2  2  3  2  2  2  2     2  3     2     1  2  3  2  2  2  2  1  1|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |       1        1  1              1  1  1        2     1  1  1           1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +           +                 +                 +  +               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +     +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                             1            |             
      Nephropathy                          |       1        1  1  1           1  1  1                          1      |             
      Pigmentation, Hemosiderin            |                         2                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | I  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3|            |
                                           | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  M  +  +|  42        |
      Inflammation, Suppurative            |                                                             1            |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Necrosis                             |                2                                                         |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  4.0|
      Basophilic Focus                     |                            X                                             |      2     |
      Eosinophilic Focus                   |    X  X     4     X  X     X     X              X     X  X  X  X  X  X  X|     28  4.0|
      Hematopoietic Cell Proliferation     |    1  2  3  1                 1                                2         |     12  1.5|
      Hyperplasia, Lymphoid                |                                                             2            |      1  2.0|
      Mineralization                       |                            1                                             |      1  1.0|
      Necrosis                             |                   1     1  1                                             |      7  1.4|
      Regeneration                         |                               2                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                    4                     |      1  4.0|
      Bile Duct, Cyst                      |                                                                   2      |      1  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      3  1.3|
      Centrilobular, Degeneration          |    1                                         4                           |      3  2.3|
      Centrilobular, Necrosis              |                                                                2         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +        +              +  +     +  +     +  +     +           +  +|  21        |
      Angiectasis                          |                                                    2                     |      1  2.0|
      Fat, Necrosis                        |    2  3        1              4  2     3  4     2        3           4   |     18  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                2         |      1  2.0|
      Atrophy                              |                               1                                          |      3  1.0|
      Hyperplasia                          |                                                             1            |      1  1.0|
      Hypertrophy                          |                1                       1                 1               |      4  1.0|
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      3  3.7|
      Inflammation, Suppurative            | 2           3        1        2                                      2   |      8  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3|            |
                                           | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                        2           2  2                  |      5  1.8|
      Epithelium, Hyperplasia              | 2           4  4     4  2  2  2  2     4           4  4     1     2  4   |     27  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Hyaline                |                   1                                                      |      1  1.0|
      Inflammation, Suppurative            | 1              1              2                                          |      4  1.5|
      Epithelium, Hyperplasia              | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1     1     1  2        1  1     1  1     1  1        1  1     1  1|     33  1.1|
      Artery, Inflammation                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hypertrophy                          |                                                       1                  |      2  1.5|
      Necrosis                             |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                         1|      1  1.0|
      Necrosis                             |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  M  +  +  M  +  +  M  +  +  M|  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |                   4  1        1           1     3           3  2         |      9  1.9|
      Pars Intermedia, Hyperplasia         |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |                1                                                  2      |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  M  +  M  +  M  +  +  M  M  M  +  +  +  +  +  M  M  +  +  +  M  +  M|  35        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                 2  2              2      |      6  2.0|
      Cyst                                 |    1  1  2  1                          2                                 |      6  1.5|
      Fibrosis                             |                                                    2                     |      1  2.0|
      Hemorrhage                           |                                                    2                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3|            |
                                           | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Corpus Luteum, Hyperplasia           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                  2        4                              |      2  3.0|
      Hemorrhage                           |             4                                                            |      2  3.0|
      Hydrometra                           |                3                 2                    3     3            |      8  3.0|
      Hyperplasia, Cystic                  |                                  4                                       |      3  3.7|
      Endometrium, Hyperplasia             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |       2  2                    2                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Iliac, Hyperplasia                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  M  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +|  38        |
      Hyperplasia                          |                                                    2              2      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  M  +  M  +  +  +  +|  40        |
      Hematopoietic Cell Proliferation     |          2                                                               |      1  2.0|
      Hyperplasia                          |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Congestion                           |                      2                                                   |      1  2.0|
      Hematopoietic Cell Proliferation     |          4                                                               |      1  4.0|
      Hemorrhage                           |                                                          3               |      1  3.0|
      Hyperplasia                          | 4                    2                                                   |      2  3.0|
      Inflammation, Chronic                |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  M  M  +  M  +  +  +  +|  40        |
      Hyperplasia                          |                                        2                          2      |      7  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 3  4  4  3  3     2  2  2  1  2  2        2  4  3  2  2  3     4        4|     39  2.9|
      Hyperplasia, Lymphoid                |                                        2                    3            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M|  39        |
      Atrophy                              |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                         4|      1  4.0|
      Hyperplasia                          |                                                    2                     |      3  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sebaceous Gland, Hyperplasia         |                                                    2                     |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3|            |
                                           | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                      2     1                          1                  |      9  1.6|
      Fracture                             |                                     X                                    |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Inflammation, Chronic      |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            1                                      1      |      5  1.2|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Epiglottis, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 2                                                                        |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |       2     2  3     2     2     3     2  2     3  2  2        2  4  2   |     23  2.4|
      Inflammation, Chronic, Focal         |                                           2                              |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                2                                                         |      4  1.8|
      Bronchiole, Hyperplasia              | 2     2  1  4  2  3     3  2     2     2  2  1     4     1           1   |     30  2.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                     4                                    |      1  4.0|
      Inflammation, Suppurative            |                                                 2  1              1      |      4  1.5|
      Metaplasia                           |                                                                          |      1  1.0|
      Olfactory Epithelium, Atrophy        | 3  2  2  2  3  1  2  1     1  2  2  2  2  1     3  2  2  1  2  2  3  2  2|     47  2.0|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Adenomatous                     | 2  2  2  2  2  2  2  2     2  2  2     2  1     2  2  2  2  2     2  2  2|     44  1.9|
      Olfactory Epithelium, Metaplasia     | 3  2  2  2  3  1  2  1     1  2  2     2  1     3  2  2  1  2  1  2  2  2|     44  2.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 1  1  1     2  1              2  1     1              2  1  1     1  2  1|     25  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                          +                          +               |   9        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                             +            |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3|            |
                                           | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy                          | 1  1  1        1     2                 1  1        1  1     1        1  1|     20  1.1|
      Pigmentation, Hemosiderin            |    2                                                                    2|      3  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3|             
                                           | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  I  A  +  +  +  +  +  +|             
      Degeneration, Hyaline                |       2                                                                  |             
      Inflammation, Suppurative            |                                                                         1|             
      Necrosis                             | 1                                                                        |             
      Epithelium, Hyperplasia              | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |          X                             X              X                  |             
      Clear Cell Focus                     |                                                                         X|             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                   X           X  X                 X                     |             
      Hematopoietic Cell Proliferation     |                                                          2               |             
      Karyomegaly                          |       1                 2  2  1           1     1     1        2         |             
      Necrosis                             |                      2        2     4           4        1           1   |             
      Regeneration                         |    2  3  4     3        2  3                    3  4        3  3         |             
      Vacuolization Cytoplasmic            |                                                                         1|             
      Bile Duct, Hyperplasia               |    2  3  2     2        2  3  2           1     2  3  2     2  2  1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1  1                                                           1|             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                     2                                    |             
      Epithelium, Hyperplasia              |             4                       2                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               2                                          |             
      Necrosis                             |                      1        2                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
      Developmental Malformation           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3|             
                                           | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 1  1  1  2  1  1  1  1  1  1     1  1  1  1  1  1     1  2  1  1  1  1  1|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                              1   |             
      Hypertrophy                          | 1                 1  1        1  1           1                       1  1|             
      Capsule, Hyperplasia                 |                                        2                       3         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        4                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  M  +  I  +  M  M  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |             4                                4                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             3                                                  3         |             
      Inflammation                         |                      1                                         3         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1                                                               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         1|             
      Inflammation, Focal, Granulomatous   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                               3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +|             
      Hyperplasia                          |    3                                            2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  +  M  M  +  M  M  +  +  M  M  +  +  M  +  +  +  M  +  +  I  +  M|             
      Hyperplasia                          |                                                 3                    2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3|             
                                           | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        4                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  M  +  +  +  M  +  M  M  +  +  +  +  +  +  M  M  M  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4        2  1              2  3  2  2     2     1     3  3               |             
      Hyperplasia, Lymphoid                |                2                             1  2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  M  M  +  +  M  M  +  +  +  +  M  I  +  M  +  +  I  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Prepuce, Inflammation, Chronic Active|          4                                               4               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Inflammation, Chronic      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  1     1              1                  |             
      Epiglottis, Metaplasia, Squamous     |                                           1                              |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1                          1                                2            |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   1                             1                        |             
      Perivascular, Infiltration Cellular  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         1                                         3      |             
      Olfactory Epithelium, Atrophy        |             1                       1     1                       2      |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Adenomatous                     |                                     1                                    |             
      Olfactory Epithelium, Metaplasia     |             1                             1                       1      |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                1                             2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3|             
                                           | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Inflammation                         |                                              4                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |          2                                               4               |             
      Metaplasia, Osseous                  |                1                                                         |             
      Nephropathy                          | 1  1  2  2  2  1  2     1  1  1  1     1  2  2  1  1  2  2  1  1  1  1  1|             
      Papilla, Necrosis                    |                                     3                                    |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                      +   |             
      Transitional Epithelium, Hyperplasia |                                                                      2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          2                                               3               |             
      Transitional Epithelium, Hyperplasia |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7|            |
                             DAY ON TEST   | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3|            |
                                           | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  A  +  +  +  +  A  +  A  +|  41        |
      Degeneration, Hyaline                |    2              3     2                 3                              |      5  2.4|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  M  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                   2                          3                           |      2  2.5|
      Basophilic Focus                     | X                                                                        |      4     |
      Clear Cell Focus                     |                                                                          |      1     |
      Congestion                           |                                                 3                        |      1  3.0|
      Degeneration, Cystic                 |                                                             4            |      1  4.0|
      Eosinophilic Focus                   |          X  X           X                                                |      7     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Karyomegaly                          | 2  1        2     3     3     1  1        1     1        1     1         |     19  1.5|
      Necrosis                             |          4                                               4           1   |      9  2.6|
      Regeneration                         | 4  2  2  2        3           3           2  4        2  2  4           2|     22  2.8|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               | 3  2  2  2  2     2     3     2  2     1  2  4  1     2  2  3  1  2  1  2|     34  2.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                 +      |   2        |
      Fat, Inflammation, Chronic           |                                                                   4      |      1  4.0|
      Fat, Necrosis                        |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                1                                                         |      4  1.0|
      Hypertrophy                          |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                   2                                                      |      2  2.0|
      Epithelium, Hyperplasia              |    2              4                                                      |      4  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7|            |
                             DAY ON TEST   | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3|            |
                                           | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   2        |
      Developmental Malformation           |                         X                                                |      2     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  1  2  1  1  1  1  1  1     2  1  1     1     1  1  1     1     1  1|     43  1.1|
      Atrium, Thrombosis                   |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  1.5|
      Hypertrophy                          |          1     1                 2  1     1                              |     13  1.1|
      Capsule, Hyperplasia                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        1                 2               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  M  +  +  +  +  M  +  I  +  M  +  +  +  +  +  +  +  M  +  +|  35        |
      Hyperplasia                          |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           |                                              1                           |      1  1.0|
      Pars Intermedia, Hyperplasia         |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |       1  1                                2                             1|      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                         1                                                |      3  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2  3.0|
      Inflammation                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                    1                     |      2  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         | 2                       3                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7|            |
                             DAY ON TEST   | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3|            |
                                           | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                         2                                                |      2  1.5|
      Inflammation, Focal, Granulomatous   |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                    3                     |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  +  M  +  +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  M  M  M|  32        |
      Hyperplasia                          |                                                       2     2            |      4  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  M  +  +  +|  32        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|  47        |
      Hyperplasia                          |                                                       2                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  M  M|  34        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 3  3  2     3        3  3        2              2  2     4  2  3  2  3  2|     26  2.5|
      Hyperplasia, Lymphoid                |                                        2                          2      |      5  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  M  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  34        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Inflammation, Chronic Active         |                         3                                                |      1  3.0|
      Prepuce, Inflammation, Chronic Active|          2                                         4                     |      4  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                             1            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Inflammation, Chronic      |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      3  1.0|
      Epiglottis, Metaplasia, Squamous     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |    1                       2                          2        2         |      7  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7|            |
                             DAY ON TEST   | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3|            |
                                           | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis                           |                                                                      1   |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                              2                           |      3  1.3|
      Perivascular, Infiltration Cellular  |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Olfactory Epithelium, Atrophy        |                1                                         1              1|      7  1.1|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Adenomatous                     |                                                          1              1|      3  1.0|
      Olfactory Epithelium, Metaplasia     |                1                                         1              1|      6  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                                                 1                        |      3  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Squamous                 |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                            +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         1                                                |      1  1.0|
      Inflammation, Chronic Active         |    2                                               2                     |      4  2.5|
      Metaplasia, Osseous                  |                                           1  1                           |      3  1.0|
      Nephropathy                          | 1  2  1  1  2  1  1  2  1  1  1  3  1  2  1  1  2  1  1  1  1     1  1  1|     47  1.3|
      Papilla, Necrosis                    |                                                                          |      1  3.0|
      Renal Tubule, Necrosis               |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                    3                     |      3  2.7|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3|             
                                           | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  M  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Hyaline                |             1                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                   4      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      4                                         2         |             
      Basophilic Focus                     |                                           X                              |             
      Clear Cell Focus                     |                                           X                              |             
      Degeneration, Cystic                 |                                                                   3      |             
      Eosinophilic Focus                   |                      X                       X              X            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Karyomegaly                          | 1  1     2                          2                 1  1        2      |             
      Necrosis                             | 4     4                                   4           1              2   |             
      Regeneration                         | 2  4        3  2           4        4                 2  3     2  4      |             
      Bile Duct, Hyperplasia               | 2  3     2  2  2           3        3  2     1        2  2     2  2     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +                          +              +   |             
      Fat, Inflammation, Chronic           |                                                                      3   |             
      Fat, Necrosis                        |                                                       3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1                                                        1      |             
      Cytoplasmic Alteration               |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |       2                                   2                              |             
      Epithelium, Hyperplasia              |       2                                   3           2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                     +                                    |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3|             
                                           | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1  1  1  1     1     1  1  1  1     1  1  2  1  1  1  1  1  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                          2              1            |             
      Hypertrophy                          |    1                 1                    1           1        1  2     1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                1     1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  M  +  +  +  +  +  M  +  I  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    1                                                        1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Cyst                                 |                                  3  3     3                              |             
      Inflammation                         |                                              2  3                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                                      |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                           2                 2            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  M  +  +  M  M  M  M  M  +  +  +  +  +  M  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  M  +  M  +  +  M  M  M  +  +  +  +  +  +  +  M  M  +  +  +|             
      Hyperplasia                          |                                                                         4|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3|             
                                           | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                  2                                       |             
      Hyperplasia                          |                                                                      3  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  I  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  1  1  2              3        2              2     2     2        2  2|             
      Hyperplasia, Lymphoid                |                                                    3           2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  M  M  M  I  +  M  I|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         4|             
      Prepuce, Inflammation, Chronic Active|                                                 3  3                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                3  3           4                                         3|             
      Inflammation, Chronic, Focal         |                                                                      3   |             
      Alveolar Epithelium, Hyperplasia     |                   4        2                       3        1            |             
      Bronchiole, Hyperplasia              |       1        2                                         1               |             
      Mediastinum, Inflammation, Chronic   |                                                                      2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                   1      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Olfactory Epithelium, Atrophy        |    2                                            1                 1      |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Adenomatous                     |    1                                                                     |             
      Olfactory Epithelium, Metaplasia     |    2                                                                     |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    1                                            1                        |             
      Respiratory Epithelium, Polyp,       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3|             
                                           | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Inflammatory                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                    +                             +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                                                                     |             
      Hydronephrosis                       |                                                 2                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  1  1  2  1  1  1  2     1  1  1  1     1  1  1  1  1  1  1  1  1  3  1|             
      Renal Tubule, Hyperplasia            |       1     1              2                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6|            |
                                           | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  +  A  +  +  M  +  +  A  +  +  A  +  +  A  +  +  +  +  +|  40        |
      Degeneration, Hyaline                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +|  44        |
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              2                           |      3  2.7|
      Basophilic Focus                     |                               X                                          |      2     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Eosinophilic Focus                   |    X        X                                                     X  X   |      7     |
      Hematopoietic Cell Proliferation     |                                  2                                       |      1  2.0|
      Karyomegaly                          |    2                                         2        2     1  2     1   |     13  1.5|
      Necrosis                             |                                                    4                    2|      7  3.0|
      Regeneration                         |    2  3  3     3  4        4        4  3  4  2     4  2     4  4     2   |     25  3.1|
      Bile Duct, Hyperplasia               | 1  2  3  2     3  2        3  2     4  2  4  3     2  2     3  3     1   |     31  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                    +              +           +                        |   8        |
      Fat, Inflammation, Chronic           |                                                                          |      1  3.0|
      Fat, Necrosis                        | 3                                                                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Atrophy                              |                                                                      1  1|      4  1.0|
      Cytoplasmic Alteration               |                               1                                          |      1  1.0|
      Hypertrophy                          |                                        1                                 |      1  1.0|
      Duct, Cyst                           |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Infiltration Cellular, Mast Cell     |                                     2                                    |      1  2.0|
      Inflammation, Suppurative            |                                           1                              |      1  1.0|
      Ulcer                                |                                                                1         |      3  1.7|
      Epithelium, Hyperplasia              |                                     1                          1  2      |      6  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                     2                                    |      1  2.0|
      Mineralization                       |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +           +                                                            |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6|            |
                                           | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Developmental Malformation           | X           4                                                            |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                     +                                    |   2        |
      Mineralization                       |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 1  2  1  1  1  1  1  1  1     1     2  1  1  1  2  1  1     1  1  1  1  1|     43  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                   2      |      4  1.8|
      Hypertrophy                          | 1     2     1  1        1  1           1  1                              |     15  1.1|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                1         |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Hyperplasia                          | 1                                                                        |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  I  +  M  +  +  M  +  +  M  M  +  +  +  +  A  M  +  M  M  M|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
      Pars Distalis, Hyperplasia           |                               2           1                              |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         | 1  1                                                                 1   |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Cyst                                 | 2                       3           2                          2         |      7  2.6|
      Inflammation                         |                         2                                               2|      4  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Inflammation                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Atrophy                              |                                                    1                 1   |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6|            |
                                           | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Hyperplasia                          |                                  2                                       |      1  2.0|
      Infiltration Cellular, Mast Cell     |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  M  M  M  M  M  +  +  M  M  M  M  +  M  M  +  M  M  M  M  +  +  M|  23        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | I  +  +  M  M  M  M  +  M  +  M  +  +  +  +  +  +  M  M  A  M  M  M  M  +|  28        |
      Hyperplasia                          |                            2                                             |      2  3.0|
      Infiltration Cellular, Mast Cell     |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Angiectasis                          |                   2                                            2         |      3  2.0|
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  A  +  +  +  +  M|  38        |
      Hyperplasia                          |       3  3                 2        4                                    |      4  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |    3     2     2     2           3  3  2  2        2        3  2         |     22  2.1|
      Hyperplasia, Lymphoid                |                            4                                             |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  M  M  +  +  +  M  M  +  +  +  M  M  +  M  M  +  +  M  M|  28        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Prepuce, Inflammation, Chronic Active|          3                       4                                   3  4|      6  3.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
      Hyperplasia                          |                                     2        1                           |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                2         |      1  2.0|
      Infiltration Cellular, Histiocyte    |       4           3  2        4                                          |      8  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6|            |
                                           | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic, Focal         |                                                                         2|      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                                              1                           |      5  2.2|
      Bronchiole, Hyperplasia              | 2  2  2                 4              1     3     2                     |     10  2.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                     2                                    |      1  2.0|
      Olfactory Epithelium, Atrophy        | 2  1        2  1              1                                          |      8  1.4|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Adenomatous                     |    1                                                                     |      2  1.0|
      Olfactory Epithelium, Metaplasia     |    1        2  1              1                                          |      5  1.4|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |             2                    1                                       |      4  1.3|
      Respiratory Epithelium, Polyp,       |                                                                          |            |
          Inflammatory                     |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   1        |
      Inflammation                         |                                                                   4      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                         +      |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Cyst                                 |                                           2                              |      2  2.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |          2                       4                                       |      2  3.0|
      Metaplasia, Osseous                  |                                                                      1   |      1  1.0|
      Mineralization                       |                                     3                                    |      1  3.0|
      Nephropathy                          | 1  2  1  1  1  1  1  1  1  1  2        1  1  2  1  1  1        1  1  2  1|     44  1.2|
      Renal Tubule, Hyperplasia            |                            1                                             |      4  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                  4                                       |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6|             
                             DAY ON TEST   | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6|             
                                           | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  A  +  M  +  +  +  +  +  +  +  A  M  +  M  +  +  M  +  A  +|             
      Degeneration, Hyaline                |          3                                                               |             
      Inflammation, Suppurative            |                                     1                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                         X                                               X|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Karyomegaly                          |       2     2     2  2        2        2     2  1           2        2   |             
      Mitotic Alteration                   |                            3                                             |             
      Necrosis                             |             2        4                    4                              |             
      Regeneration                         | 2     2  2  3     3  3                 4                    4  4  3     2|             
      Bile Duct, Hyperplasia               | 2     3  2  3     2  2  1     3        4  2  2  2     1     3  3  3  2  3|             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +           +     +  +     +           +     +     +        +|             
      Angiectasis                          |                                                                2         |             
      Fat, Necrosis                        |                               2                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Cytoplasmic Alteration               |                                                                         2|             
      Hypertrophy                          |                                                                   1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Suppurative            |                                                                1         |             
      Ulcer                                |                                                       2                  |             
      Epithelium, Hyperplasia              |                                                       3  3     3  1      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      1                                                   |             
      Necrosis                             |                                           1                              |             
      Pigmentation                         |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +                                                      |             
      Inflammation                         |                   3                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1  1  1  1  2  1  1     1  1     1  1  1  1     1  1  1     1|             
      Hyperplasia, Atypical                |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6|             
                             DAY ON TEST   | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6|             
                                           | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                   2                                                      |             
      Mineralization                       |                                                                          |             
      Artery, Inflammation                 |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         1|             
      Hypertrophy                          | 1                                   1           1  1     1              1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                         1           2     2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          |             1                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  M  M  M  +  M  M  +  M  +  +  +  M  +  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                     1                                    |             
      Pars Nervosa, Inflammation           |                                                             2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 1              1                                4                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Hyperplasia                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                             +            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                   2                                                      |             
      Inflammation                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                4                                                         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation                         |                4                                                         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2  2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                                                         |             
      Iliac, Hyperplasia                   |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  M  M  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  M  +  M  +  I|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6|             
                             DAY ON TEST   | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6|             
                                           | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  M  +  M  +  +  M  +  +  +  +  +  M  M  M  M  M  M  M  M  +  M  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  +  +  M  M  +  +  M  M  +  +  M  +  +  +  +  M  +|             
      Hematopoietic Cell Proliferation     |                      2                                                   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                   X      |             
      Hematopoietic Cell Proliferation     |    3  2  2     2  2  4     1  3     2     3  1     3  1  4  2  3  1  3  3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  M  M  M  +  +  M  +  +  +  M  I  +  +  +  +  M  M  +  +  I|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      3                                         3         |             
      Inflammation, Chronic Active         |       2                                                                  |             
      Prepuce, Inflammation, Chronic Active|                   3                             3           4            |             
      Subcutaneous Tissue, Cyst            | 3                                   3                                    |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Granulomatous            |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Inflammation, Chronic      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |       2     2              1              2  3     1                     |             
      Alveolar Epithelium, Hyperplasia     |                      2                                      2            |             
      Bronchiole, Hyperplasia              | 2                 2     2     1     2     1        2                    1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Olfactory Epithelium, Atrophy        |             1  1              2                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                         1                                                |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6|             
                             DAY ON TEST   | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6|             
                                           | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Adenomatous                     |                                                                          |             
      Olfactory Epithelium, Metaplasia     |             1  1                                                         |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                   1           1                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +        +              +     +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   2      |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic Active         |                4                                                         |             
      Nephropathy                          | 1  1  1  1  1     1     1  1  1  1  2  2  1  2  2  1  1  2  2  1  3     1|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Renal Tubule, Hyperplasia            |                                        1        2                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                3                                                         |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7|            |
                                           | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  M  +  M  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +|  37        |
      Degeneration, Hyaline                |                            4                                             |      2  3.5|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Peyer's Patch, Hyperplasia           |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Eosinophilic Focus                   |                                                                   X      |      3     |
      Hematopoietic Cell Proliferation     |                                                          2               |      1  2.0|
      Karyomegaly                          | 1        1  1  2     1  1           2           2        2        1      |     20  1.7|
      Mitotic Alteration                   |                                                                          |      1  3.0|
      Necrosis                             |             1        3                       2              4            |      7  2.9|
      Regeneration                         | 4  2  2  4     4     3  2  2     3  4           4        3  4     2      |     25  3.0|
      Bile Duct, Hyperplasia               | 2  2  2  4  1  4     2  2  1     2  3           3     1  3  3     2      |     34  2.4|
      Centrilobular, Necrosis              |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +     +                    +              +              +  +|  16        |
      Angiectasis                          |                                                                         2|      2  2.0|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                          1  1            |      2  1.0|
      Basophilic Focus                     |       X                                                                  |      1     |
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Hypertrophy                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                         1                                   2            |      3  1.3|
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                         2              1                    3            |      7  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  1.0|
      Pigmentation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7|            |
                                           | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  1  1  2     1  1  1     1     1  1     1  1  1     1     1  1  1  2  1|     40  1.1|
      Hyperplasia, Atypical                |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      1  2.0|
      Mineralization                       |                                                       1                  |      1  1.0|
      Artery, Inflammation                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  1                                1      |      3  1.0|
      Hypertrophy                          |          1     1              1  1           2  1                        |     12  1.1|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      1                                                   |      5  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                               1                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  M  M  +  M  M  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  1.0|
      Pars Nervosa, Inflammation           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |          1                             1        1                        |      6  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                      3                                                   |      1  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  I  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                   3      |      2  2.5|
      Inflammation                         |       1                             2                                    |      3  1.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Inflammation, Suppurative            |                                           3                              |      2  3.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7|            |
                                           | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                   1      |      1  1.0|
      Atrophy                              |                                                       1                  |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                          2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                         +|   2        |
      Iliac, Hyperplasia                   |                                                                         2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  +  +  +  M  M  M  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +|  33        |
      Hyperplasia                          |                                     2                             2      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  M  +  +  +  +  M  +  +  M  +  M  +  +  +  M  +  +  +  +  M  M|  27        |
      Hyperplasia                          |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|  46        |
      Angiectasis                          | 2  1                 2                                                   |      3  1.7|
      Hyperplasia                          |                                        4                    4            |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  M  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|  37        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                            2  3                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation     | 3  2  2  2  4  3  3  3  2              3  2           2     2  2     4  2|     35  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M  +  +  +  M  M  +  +  M  M  +  M  +  M  +  M  +  M  M  M  +  M  +|  25        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Prepuce, Inflammation, Chronic Active|                                           4                             4|      5  3.6|
      Subcutaneous Tissue, Cyst            |                                                                          |      2  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Granulomatous            |          3                                                               |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7|            |
                                           | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Meninges, Inflammation, Chronic      |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |          2                 3  4                             4  3         |     11  2.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
      Bronchiole, Hyperplasia              | 2  1  1  2  1     2  1                             1              4  3   |     18  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          1  1              1                                      1      |      4  1.0|
      Olfactory Epithelium, Atrophy        |       1        1                                1           1            |      7  1.1|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                                                                          |      1  1.0|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Adenomatous                     |                1                                            1            |      2  1.0|
      Olfactory Epithelium, Metaplasia     |       1        1                                            1            |      5  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +           +     +  +  +  +                 +               |  11        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Hydronephrosis                       |                   1                                                      |      1  1.0|
      Inflammation, Chronic Active         |                                                          3              2|      3  3.0|
      Nephropathy                          | 1  1  1  1  1  1  1  3  1  1  1     1     2  2  1     1     1  2  2  1  2|     43  1.3|
      Pigmentation, Hemosiderin            |                                                                      2   |      1  2.0|
      Renal Tubule, Hyperplasia            |       1  1  1                                                            |      5  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                           1                             4|      3  2.7|
      Transitional Epithelium, Hyperplasia |                                           2                              |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5|             
                                           | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                         1                                                |             
      Inflammation, Suppurative            |                                                       2                  |             
      Epithelium, Hyperplasia              |                                                       3                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  M  +  M  M  +  +  M  I  +  +  +  +  +  +  +  M  +  +  +|             
      Degeneration, Hyaline                |                2     2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3                                                |             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |    X        X                          X        X        X               |             
      Hematopoietic Cell Proliferation     |                                                 1                        |             
      Karyomegaly                          | 1     2     1        1  2              3  2                 2  3  1  1   |             
      Necrosis                             |                                     4        4                           |             
      Regeneration                         | 2           3        2     2     2     3  3                 4  4  2  3  2|             
      Bile Duct, Hyperplasia               | 3     2     3  2  2  3  2  2     3     3  3                 4  4  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +           +  +                                +            |             
      Inflammation, Focal, Granulomatous   |                         2                                                |             
      Thrombosis                           |                                                                          |             
      Fat, Necrosis                        |                            3                                             |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                   +                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        1                                 |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                     2                             2      |             
      Ulcer                                |             2              2              2              2  1     2     2|             
      Epithelium, Hyperplasia              | 2  1        3  1        2  3        2     3     1        3  2     4     3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5|             
                                           | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 1  1  1     1     1  1  1  1  1  2  1  1     1     1  1  1  1  2  1  1  1|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |       1                 1                                                |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1           2                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                1         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  I  M  M  +  +  M  M  +  +  M  +  M  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 1                       1           1                 2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                1                                                         |             
      Inflammation                         |                                                                         1|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                         2                 3                             2|             
      Fibrosis                             |                                     2                                    |             
      Inflammation                         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            2                       1                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 2     2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +              +                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  M  M  M  +  M  M  M  +  M  +  +  +  +  M  M  +  M  M  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  M  +  +  M  +  +  +  M  +  M  +  M  M  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  I  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5|             
                                           | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                                                  |             
      Hematopoietic Cell Proliferation     |    2  2  3  2  3  3           2     3  2     4  2     2     3  3  3  2  2|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  I  +  M  M  +  +  +  M  +  +  +  M  +  M  M  M  +  +  +  +  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   4           4                                4         |             
      Epidermis, Hyperplasia               |                                                                          |             
      Prepuce, Inflammation, Chronic Active|                                                       4                  |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                    2                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1                             1                     |             
      Inflammation, Suppurative            |                                                                          |             
      Epiglottis, Metaplasia, Squamous     |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2     2     4  3              2     3           2        2        4  4  4|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Bronchiole, Hyperplasia              |       1  2     1                 2  3     2  2        2     3            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             1           1                                                |             
      Lateral Wall, Necrosis               |                                                                          |             
      Olfactory Epithelium, Atrophy        | 3     3  1  3  3  3  2  3  3  2  3  3  2  2  2  3  2  2  3  2  2  3  2  3|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                                                          |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Adenomatous                     | 2     2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  3  2  2  2  2  2|             
      Olfactory Epithelium, Metaplasia     | 3     3  1  3  3  3  2  3  3  2  3  2  2  2  2  3  2  2  3  2  2  3  1  3|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5|             
                                           | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Hyaline                         |                            1        1                 1           1      |             
      Respiratory Epithelium, Necrosis     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Inflammation                         |                                           4                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  M     +                       +     +              +  +            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | M  M  M                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |    3                                               4                     |             
      Hydronephrosis                       |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 1     1  1  1  3  3     2  1     1  1     1  1        1  1  1  2  2  1  1|             
      Pigmentation, Hemosiderin            |                                        2                                 |             
      Renal Tubule, Hyperplasia            |                   1                 1                                2   |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 5| 7| 6| 6| 7| 6| 5| 5| 6|            |
                             DAY ON TEST   | 9| 3| 8| 3| 3| 4| 3| 4| 0| 2| 3| 7| 2| 7| 3| 4| 2| 3| 2| 7| 3| 6| 6| 8| 5|            |
                                           | 5| 3| 7| 5| 3| 9| 3| 4| 0| 8| 7| 7| 0| 2| 3| 9| 3| 3| 4| 7| 3| 3| 7| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  M  +  M  A  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Degeneration, Hyaline                |                                                             4            |      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Peyer's Patch, Hyperplasia           |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |                1                                                         |      1  1.0|
      Eosinophilic Focus                   |       X        X                             X                           |      8     |
      Hematopoietic Cell Proliferation     |          3     3                                               2         |      4  2.3|
      Karyomegaly                          | 3  2  3        1  1  1  2  3  2  2        1     3     1     1  2  1  2  4|     29  1.9|
      Necrosis                             |          1                    4                                4        4|      6  3.5|
      Regeneration                         | 4  4  4     2           2  4  3  4  4     3     2  3           2     4  4|     27  3.0|
      Bile Duct, Hyperplasia               | 4  3  4     2  1  2  4  3  4  2  4        4     3  3  2     3  3  3  3  4|     36  2.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +              +        +     +        +              +               |  11        |
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Thrombosis                           |                                  3                                       |      1  3.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                  1                                       |      2  1.0|
      Hyperplasia                          |    1                                                                     |      1  1.0|
      Hypertrophy                          |                                     1                    1               |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                         2  1                 2                           |      5  1.8|
      Ulcer                                | 2                 2                    2                    2  1         |     12  1.8|
      Epithelium, Hyperplasia              | 2           3     3     2  1        1  3  2  2  2  1  2     3  2  4     2|     29  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                                                   1      |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05136-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 10/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:15:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 5| 7| 6| 6| 7| 6| 5| 5| 6|            |
                             DAY ON TEST   | 9| 3| 8| 3| 3| 4| 3| 4| 0| 2| 3| 7| 2| 7| 3| 4| 2| 3| 2| 7| 3| 6| 6| 8| 5|            |
                                           | 5| 3| 7| 5| 3| 9| 3| 4| 0| 8| 7| 7| 0| 2| 3| 9| 3| 3| 4| 7| 3| 3| 7| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1  1  1  1  2  1  2  1  1  1  1  1  1  2  1  1  1  1  2  1  1  1  1  2|     45  1.2|
      Atrium, Thrombosis                   |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypertrophy                          |    1     1        1           1           1  1           1               |      9  1.0|
      Capsule, Hyperplasia                 |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                               2              1        1                  |      4  1.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  M  +  M|  30        |
                                            ______________________