TDMS Study 05136-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Northwest CHLOROPRENE DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 TIME: 10:29:16 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01-ES-05291 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 50522B PATHOLOGIST: R. MILLER CAS: 0000126-99-8 ------------------------------------------------------------------------------------------------------------------------------------ CORE STUDY REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Northwest CHLOROPRENE DATE: 10/04/96 EXPERIMENT: 05136 TEST: 08 TIME: 10:29:16 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-05291 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 50522B PATHOLOGIST: R. MILLER CAS: 0000126-99-8 CHLOROPRENE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 733 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = CONTROL | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 | | | | UNCENSORED DEATHS | | 452 535 553 570 596 603 606 607 627 628 | | 635 635 638 664 666 674 680 684 684 719 | | 722 729 729 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 12.8 PPM | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 | | | | UNCENSORED DEATHS | | 439 523 530 546 579 582 583 596 607 614 | | 626 635 635 638 659 667 680 688 691 691 | | 701 708 722 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 32 PPM | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 | | | | UNCENSORED DEATHS | | 382 439 470 491 495 502 545 551 565 567 | | 579 596 602 606 607 607 607 620 623 629 | | 635 649 663 666 666 679 679 680 688 688 | | 693 701 705 713 715 717 | | CENSORED DEATHS | | NONE | | | ================================================================================== CHLOROPRENE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 733 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 80 PPM | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 13 | | | | UNCENSORED DEATHS | | 392 422 454 523 524 567 579 587 589 595 | | 600 603 608 620 624 624 628 635 635 637 | | 644 644 649 649 649 656 657 659 659 663 | | 672 677 677 680 687 701 701 | | CENSORED DEATHS | | NONE | | | ================================================================================== CHLOROPRENE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 733 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 733 (A) | | | |--------------------------------------------------------------------------------| | | | |CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 88.0 72.0 54.0 | | | | | | | |12.8 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 84.0 70.0 54.0 | | | | | | | |32 PPM | 100.0 100.0 100.0 100.0 98.0 94.0 86.0 74.0 54.0 28.0 | | | | | | | |80 PPM | 100.0 100.0 100.0 100.0 96.0 94.0 90.0 76.0 40.0 26.0 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | CONTROL 12.8 PPM 32 PPM 80 PPM | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 54.0% 54.0% 28.0% 26.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P<0.001 P=1.000 P=0.007 P=0.003 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 636.3 623.5 611.7 615.4 | |NATURAL DEATHS (C) | (14.1) (14.6) (14.0) (11.9) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 688.5 682.6 645.6 646.0 | |(STANDARD ERROR) | ( 9.4) (10.2) (12.7) (11.4) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) CHLOROPRENE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 734 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = CONTROL | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 | | | | UNCENSORED DEATHS | | 35 477 486 493 527 541 610 635 637 663 | | 677 681 705 706 729 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 12.8 PPM | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 1 TERMINAL 16 | | | | UNCENSORED DEATHS | | 285 321 440 447 482 523 531 540 548 551 | | 551 607 621 623 624 631 631 636 673 674 | | 677 680 690 690 691 691 691 698 702 708 | | 708 719 719 | | CENSORED DEATHS | | 318 | | | |--------------------------------------------------------------------------------| | DOSE = 32 PPM | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 49 CENSORED DEATHS 0 TERMINAL 1 | | | | UNCENSORED DEATHS | | 216 346 378 389 394 425 440 454 463 472 | | 487 499 503 505 515 523 524 527 531 537 | | 539 543 551 551 572 582 588 596 604 607 | | 608 620 623 624 629 629 631 634 635 644 | | 649 652 656 656 667 671 674 691 717 | | CENSORED DEATHS | | NONE | | | ================================================================================== CHLOROPRENE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 734 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 80 PPM | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 46 CENSORED DEATHS 1 TERMINAL 3 | | | | UNCENSORED DEATHS | | 252 324 336 383 443 453 462 463 467 484 | | 523 524 524 524 531 531 538 548 565 576 | | 579 579 582 596 607 610 615 624 629 631 | | 631 631 632 632 635 635 638 649 649 652 | | 659 663 666 673 674 680 | | CENSORED DEATHS | | 3 | | | ================================================================================== CHLOROPRENE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 734 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 734 (A) | | | |--------------------------------------------------------------------------------| | | | |CONTROL | 98.0 98.0 98.0 98.0 98.0 96.0 88.0 88.0 80.0 70.0 | | | | | | | |12.8 PPM | 100.0 100.0 100.0 96.0 96.0 89.8 83.7 77.6 63.3 32.7 | | | | | | | |32 PPM | 100.0 100.0 98.0 96.0 88.0 80.0 56.0 42.0 12.0 2.0 | | | | | | | |80 PPM | 100.0 100.0 98.0 93.9 91.8 79.6 65.3 51.0 14.3 6.1 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | CONTROL 12.8 PPM 32 PPM 80 PPM | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 70.0% 32.7% 2.0% 6.1% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 P<0.001 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 573.5 606.2 554.5 563.1 | |NATURAL DEATHS (C) | (44.5) (19.5) (14.6) (14.8) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 685.8 641.3 558.1 562.1 | |(STANDARD ERROR) | (16.7) (16.7) (14.8) (18.7) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) CHLOROPRENE KAPLAN-MEIER SURVIVAL CURVES CONTROL = 1 12.8 PPM = 2 32 PPM = 3 80 PPM = 4 ------------------------------------------------------ SPECIES=MICE SEX=MALE ------------------------------------------------------- Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | 104 + | | 1 34 2 1 | 34 4 2 1 2 1 96 + 4 3 4 3 221 1 | 4 3 3 42 21 1 | 2 12 1 | 33 4 4 22 11 88 + 3 3 4 4 | 33 42 2 | 3 3 4 421 1 | 22 P 80 + 3 3 44 2 11 E | 3 34 22 R | 11 C | 33 4 21 1 E 72 + 44 2 11 N | 211 T | 211 | 3 344 22 S 64 + U | 33 1 1 R | 334 2 2 11 V | 3 3 22 1 1 I 56 + 43 3 2 2 V | 33 2 1 A | L | 44 33 48 + | 4 4 33 | 33 | 40 + 44 | 44 3 3 | | 44 33 32 + 44 33 | 4 4 | 3 3 | 4 4 24 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 16 obs hidden. CHLOROPRENE KAPLAN-MEIER SURVIVAL CURVES CONTROL = 1 12.8 PPM = 2 32 PPM = 3 80 PPM = 4 ----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | 100 + 1 1 3 4 2 | 1 3 4 2 24 3 1 | 244 3 3 43 22 111 | 433 2 2 1 1 90 + 3 3 4 4 2 21 1 | 3 3 44 22 1 1 | 3 343 2 2 1 1 | 33 4 22 1 1 80 + 3 3 4 1 1 | 3 3 2 2 11 | 33 2 2 1 1 | 33 44 22 1 1 P 70 + 3 3 22 1 E | 44 R | 334 4 C | 33 4 4 2 2 E 60 + 4 4 N | 33 22 T | 33 44 22 | 3 3 4 4 S 50 + 3 3 444 U | R | 3 334 4 22 V | 22 I 40 + 44 22 V | 3 3 22 A | 33 L | 2 2 30 + | 334 | 44 | 33 20 + 334 | 33 4 | 44 | 3 34 10 + | 334 | 343 3 4 | 3 3 0 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 20 obs hidden.