TDMS Study 05136-07 Pathology Tables
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:05:20
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 0000126-99-8
Lock Date: 05/04/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 19 21 23 27
Natural Death 1 1 1 2
Survivors
Terminal Sacrifice 29 28 26 21
Other 1
Animals Examined Microscopically 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (49) (50) (49)
Parasite Metazoan 4 (8%) 6 (12%) 2 (4%)
Intestine Large, Rectum (49) (49) (50) (50)
Inflammation, Acute 1 (2%)
Mineralization 2 (4%) 1 (2%)
Parasite Metazoan 2 (4%) 5 (10%) 7 (14%) 2 (4%)
Intestine Large, Cecum (48) (49) (50) (49)
Inflammation, Acute 1 (2%) 1 (2%)
Parasite Metazoan 5 (10%) 4 (8%) 8 (16%) 5 (10%)
Intestine Small, Jejunum (49) (49) (49) (48)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Ileum (48) (49) (49) (48)
Parasite Metazoan 1 (2%) 1 (2%)
Liver (49) (50) (50) (50)
Angiectasis 3 (6%) 7 (14%) 5 (10%) 8 (16%)
Basophilic Focus 39 (80%) 43 (86%) 45 (90%) 44 (88%)
Clear Cell Focus 15 (31%) 16 (32%) 14 (28%) 6 (12%)
Degeneration, Cystic 2 (4%)
Degeneration, Fatty 5 (10%) 5 (10%) 3 (6%) 3 (6%)
Eosinophilic Focus 2 (4%) 1 (2%) 2 (4%)
Hepatodiaphragmatic Nodule 4 (8%) 7 (14%) 9 (18%) 9 (18%)
Mixed Cell Focus 7 (14%) 6 (12%) 6 (12%) 9 (18%)
Necrosis 1 (2%) 1 (2%) 2 (4%)
Bile Duct, Hyperplasia 9 (18%) 10 (20%) 11 (22%) 16 (32%)
Centrilobular, Necrosis 1 (2%) 3 (6%) 5 (10%) 8 (16%)
Mesentery (5) (6) (8) (11)
Inflammation, Chronic Active 1 (20%) 1 (9%)
Fat, Necrosis 4 (80%) 6 (100%) 7 (88%) 9 (82%)
Pancreas (49) (50) (50) (50)
Atrophy 18 (37%) 14 (28%) 17 (34%) 9 (18%)
Basophilic Focus 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Hyperplasia 2 (4%) 1 (2%) 2 (4%)
Lipomatosis 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Metaplasia, Hepatocyte 1 (2%)
Artery, Inflammation 1 (2%)
Salivary Glands (49) (50) (50) (50)
Atrophy 1 (2%) 3 (6%)
Basophilic Focus 1 (2%)
Stomach, Forestomach (49) (50) (50) (50)
Hyperplasia, Squamous 1 (2%) 1 (2%) 3 (6%)
Mineralization 1 (2%) 1 (2%)
Necrosis 2 (4%) 3 (6%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
Stomach, Glandular (49) (50) (50) (50)
Mineralization 1 (2%) 1 (2%) 4 (8%) 3 (6%)
Necrosis 1 (2%)
Tongue (1) (4) (5) (12)
Hyperplasia, Squamous 1 (100%) 1 (25%) 1 (20%) 1 (8%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50) (50)
Cardiomyopathy 38 (78%) 38 (76%) 31 (62%) 41 (82%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Atrium, Thrombosis 1 (2%)
Schwann Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Atrophy 1 (2%)
Hyperplasia 23 (47%) 22 (44%) 22 (44%) 20 (40%)
Hypertrophy 8 (16%) 10 (20%) 7 (14%) 10 (20%)
Necrosis 2 (4%) 1 (2%)
Vacuolization Cytoplasmic 9 (18%) 5 (10%) 10 (20%) 8 (16%)
Adrenal Medulla (49) (50) (50) (50)
Hyperplasia 7 (14%) 11 (22%) 7 (14%) 10 (20%)
Islets, Pancreatic (49) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 3 (6%)
Parathyroid Gland (48) (50) (50) (48)
Fibrosis 1 (2%)
Hyperplasia 2 (4%) 1 (2%)
Pituitary Gland (48) (50) (50) (50)
Pars Distalis, Hyperplasia 9 (19%) 5 (10%) 3 (6%) 10 (20%)
Thyroid Gland (49) (50) (50) (50)
Fibrosis 1 (2%)
C-Cell, Hyperplasia 38 (78%) 38 (76%) 35 (70%) 28 (56%)
Follicular Cell, Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (46) (48) (46) (46)
Hyperplasia 2 (4%) 1 (2%) 4 (9%) 4 (9%)
Inflammation, Chronic Active 4 (9%) 4 (8%) 6 (13%) 4 (9%)
Ovary (49) (50) (50) (50)
Cyst 7 (14%) 6 (12%) 1 (2%) 3 (6%)
Inflammation, Granulomatous 2 (4%) 1 (2%) 1 (2%)
Uterus (49) (50) (50) (50)
Hydrometra 1 (2%)
Cervix, Hypertrophy 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Atrophy 3 (6%) 1 (2%)
Hyperplasia, Histiocytic 2 (4%)
Lymph Node (1) (4) (4) (5)
Iliac, Ectasia 1 (25%) 1 (20%)
Renal, Infiltration Cellular, Plasma Cell 1 (25%)
Lymph Node, Mandibular (44) (48) (37) (50)
Hemorrhage 1 (2%)
Spleen (48) (50) (50) (50)
Accessory Spleen 1 (2%) 1 (2%)
Angiectasis 1 (2%)
Fibrosis 3 (6%) 1 (2%) 3 (6%) 5 (10%)
Hematopoietic Cell Proliferation 1 (2%) 4 (8%) 4 (8%) 6 (12%)
Hemorrhage 4 (8%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (50) (50)
Galactocele 1 (2%) 1 (2%) 2 (4%)
Skin (49) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 3 (6%) 5 (10%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Fracture 1 (2%)
Hyperostosis 4 (8%) 5 (10%) 4 (8%) 3 (6%)
Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Congestion, Chronic 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Alveolar Epithelium, Hyperplasia 6 (12%) 22 (44%) 22 (44%) 34 (68%)
Artery, Mediastinum, Inflammation 1 (2%)
Nose (49) (50) (50) (50)
Inflammation, Suppurative 1 (2%) 2 (4%)
Thrombosis 1 (2%) 1 (2%) 3 (6%)
Nasolacrimal Duct, Hyperplasia, Squamous 1 (2%)
Olfactory Epithelium, Atrophy 1 (2%) 40 (80%) 50 (100%)
Olfactory Epithelium, Fibrosis 49 (98%)
Olfactory Epithelium, Hyperplasia, Basal Cell 17 (34%) 49 (98%)
Olfactory Epithelium, Hyperplasia,
Adenomatous 27 (54%)
Olfactory Epithelium, Inflammation, Chronic
Active 2 (4%) 33 (66%)
Olfactory Epithelium, Metaplasia 1 (2%) 35 (70%) 50 (100%)
Olfactory Epithelium, Necrosis 8 (16%) 12 (24%)
Olfactory Epithelium, Glands, Atypia Cellular 2 (4%)
Turbinate, Fibrosis, Focal 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (3) (2)
Cataract 1 (100%) 2 (67%) 2 (100%)
Degeneration 1 (100%)
Retina, Atrophy 2 (67%) 2 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Hydronephrosis 1 (2%)
Hyperplasia, Oncocytic 1 (2%)
Infarct 1 (2%) 1 (2%)
Mineralization 1 (2%)
Nephropathy 43 (88%) 48 (96%) 49 (98%) 49 (98%)
Artery, Inflammation 1 (2%)
Pelvis, Inflammation, Acute 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 4 (8%)
Urinary Bladder (49) (50) (50) (50)
Hemorrhage 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 34 40 41 41
Natural Death 3 1 4 5
Survivors
Terminal Sacrifice 13 9 5 4
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (49) (48) (49)
Mineralization 1 (2%)
Parasite Metazoan 4 (8%) 7 (14%) 3 (6%)
Intestine Large, Rectum (50) (47) (50) (49)
Mineralization 1 (2%) 1 (2%)
Parasite Metazoan 2 (4%) 1 (2%) 2 (4%)
Intestine Large, Cecum (48) (49) (46) (48)
Necrosis 1 (2%)
Parasite Metazoan 10 (21%) 7 (14%) 7 (15%) 6 (13%)
Intestine Small, Duodenum (50) (49) (49) (50)
Necrosis 1 (2%)
Liver (50) (50) (49) (50)
Angiectasis 2 (4%) 5 (10%) 6 (12%) 5 (10%)
Basophilic Focus 16 (32%) 17 (34%) 21 (43%) 13 (26%)
Clear Cell Focus 8 (16%) 6 (12%) 3 (6%) 2 (4%)
Degeneration, Cystic 13 (26%) 18 (36%) 20 (41%) 21 (42%)
Degeneration, Fatty 3 (6%) 4 (8%) 4 (8%) 3 (6%)
Eosinophilic Focus 3 (6%) 4 (8%)
Hepatodiaphragmatic Nodule 2 (4%) 1 (2%) 4 (8%) 3 (6%)
Inflammation, Chronic 1 (2%)
Mixed Cell Focus 1 (2%) 2 (4%) 1 (2%)
Necrosis 2 (4%) 1 (2%) 1 (2%)
Regeneration 2 (4%) 3 (6%) 3 (6%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 36 (72%) 40 (80%) 35 (71%) 34 (68%)
Centrilobular, Necrosis 13 (26%) 13 (26%) 13 (27%) 8 (16%)
Mesentery (16) (13) (18) (13)
Inflammation, Chronic Active 1 (6%) 1 (8%) 1 (8%)
Artery, Mineralization 1 (6%)
Fat, Hemorrhage 1 (6%)
Fat, Necrosis 15 (94%) 13 (100%) 14 (78%) 11 (85%)
Oral Mucosa (2) (1) (7)
Pharyngeal, Hyperplasia, Squamous 3 (43%)
Pancreas (50) (50) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 27 (54%) 27 (54%) 30 (61%) 23 (46%)
Basophilic Focus 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Hyperplasia 7 (14%) 3 (6%) 5 (10%) 1 (2%)
Artery, Inflammation 2 (4%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia, Squamous 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 5 (10%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Necrosis 2 (4%) 5 (10%) 2 (4%) 3 (6%)
Ulcer 1 (2%) 1 (2%) 6 (12%) 11 (22%)
Stomach, Glandular (49) (50) (49) (50)
Mineralization 5 (10%) 5 (10%) 3 (6%) 5 (10%)
Necrosis 2 (4%) 2 (4%) 6 (12%) 2 (4%)
Tooth (2)
Developmental Malformation 1 (50%)
Inflammation, Chronic Active 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (1)
Aorta, Mineralization 2 (67%) 1 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 43 (86%) 46 (92%) 39 (78%) 45 (90%)
Artery, Mineralization 2 (4%)
Atrium, Thrombosis 1 (2%) 1 (2%) 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Atrophy 1 (2%)
Hyperplasia 23 (46%) 25 (50%) 26 (53%) 23 (46%)
Hypertrophy 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Necrosis 2 (4%) 1 (2%) 2 (4%)
Vacuolization Cytoplasmic 1 (2%) 4 (8%) 3 (6%) 2 (4%)
Adrenal Medulla (50) (50) (49) (50)
Hyperplasia 23 (46%) 19 (38%) 19 (39%) 17 (34%)
Necrosis 1 (2%)
Islets, Pancreatic (50) (50) (49) (50)
Hyperplasia 3 (6%) 2 (4%) 3 (6%) 3 (6%)
Parathyroid Gland (48) (49) (50) (50)
Hyperplasia 5 (10%) 10 (20%) 19 (38%) 24 (48%)
Pituitary Gland (50) (49) (50) (49)
Pars Distalis, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia 7 (14%) 4 (8%) 5 (10%) 2 (4%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (49) (50)
C-Cell, Hyperplasia 34 (68%) 24 (48%) 23 (47%) 28 (56%)
Follicular Cell, Hyperplasia 2 (4%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1)
Hyperplasia 1 (100%)
Epididymis (50) (50) (50) (50)
Granuloma Sperm 2 (4%) 3 (6%) 1 (2%)
Hyperplasia 2 (4%) 6 (12%) 1 (2%)
Necrosis, Fatty 1 (2%)
Penis (1) (3)
Vein, Fibrosis 1 (33%)
Preputial Gland (50) (50) (48) (50)
Hyperplasia 4 (8%) 3 (6%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 9 (18%) 6 (12%) 3 (6%) 4 (8%)
Prostate (50) (50) (50) (50)
Hyperplasia 7 (14%) 7 (14%) 5 (10%) 4 (8%)
Inflammation, Chronic Active 2 (4%) 4 (8%) 4 (8%) 5 (10%)
Mineralization 1 (2%)
Seminal Vesicle (50) (50) (50) (49)
Amyloid Deposition 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 1 (2%) 4 (8%) 4 (8%) 1 (2%)
Hyperplasia 1 (2%)
Artery, Inflammation, Chronic Active 2 (4%) 2 (4%) 4 (8%) 3 (6%)
Interstitial Cell, Hyperplasia 10 (20%) 4 (8%) 9 (18%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Necrosis 1 (2%)
Lymph Node (12) (18) (11) (15)
Iliac, Ectasia 1 (6%)
Pancreatic, Hemorrhage 1 (9%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Renal, Ectasia 1 (7%)
Renal, Hemorrhage 1 (8%) 2 (11%) 3 (27%) 5 (33%)
Renal, Infiltration Cellular, Plasma Cell 1 (9%)
Renal, Pigmentation 1 (7%)
Lymph Node, Mandibular (47) (45) (44) (49)
Ectasia 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Plasma Cell 2 (4%) 1 (2%)
Lymph Node, Mesenteric (50) (50) (48) (50)
Hemorrhage 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Lymph Node, Mediastinal (46) (47) (48) (47)
Hemorrhage 1 (2%)
Spleen (50) (50) (49) (50)
Accessory Spleen 2 (4%) 1 (2%) 1 (2%)
Fibrosis 17 (34%) 19 (38%) 17 (35%) 20 (40%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 3 (6%) 6 (12%)
Hemorrhage 1 (2%) 1 (2%)
Metaplasia, Lipocyte 1 (2%)
Necrosis 1 (2%) 2 (4%) 3 (6%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (30) (23) (30) (28)
Galactocele 4 (13%) 3 (13%) 3 (10%) 1 (4%)
Inflammation, Chronic 1 (3%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 2 (4%) 1 (2%)
Inflammation, Chronic Active 3 (6%) 4 (8%) 8 (16%) 5 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 4 (8%) 7 (14%) 11 (22%)
Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%)
Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Necrosis 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Inflammation, Acute 1 (2%) 1 (2%)
Lung (50) (50) (49) (50)
Foreign Body 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Infiltration Cellular 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Metaplasia, Cartilagenous 1 (2%)
Metaplasia, Osseous 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 5 (10%) 16 (32%) 14 (29%) 25 (50%)
Artery, Mediastinum, Mineralization 1 (2%) 2 (4%)
Nose (50) (50) (49) (49)
Cyst 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 4 (8%)
Thrombosis 10 (20%) 9 (18%) 3 (6%) 2 (4%)
Olfactory Epithelium, Atrophy 3 (6%) 12 (24%) 46 (94%) 48 (98%)
Olfactory Epithelium, Fibrosis 47 (96%)
Olfactory Epithelium, Hyperplasia, Basal Cell 38 (78%) 46 (94%)
Olfactory Epithelium, Hyperplasia,
Adenomatous 2 (4%) 1 (2%) 42 (86%)
Olfactory Epithelium, Inflammation, Chronic
Active 5 (10%) 9 (18%) 49 (100%)
Olfactory Epithelium, Metaplasia 6 (12%) 5 (10%) 45 (92%) 48 (98%)
Olfactory Epithelium, Necrosis 11 (22%) 26 (53%) 19 (39%)
Respiratory Epithelium, Hyperplasia 1 (2%)
Turbinate, Fibrosis, Focal 5 (10%)
Trachea (50) (50) (50) (50)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
External Ear, Inflammation, Chronic Active 1 (100%)
Eye (1) (1)
Cataract 1 (100%)
Retina, Atrophy 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 3 (6%) 3 (6%) 3 (6%) 5 (10%)
Hyperplasia, Oncocytic 2 (4%)
Infarct 2 (4%) 2 (4%)
Mineralization 1 (2%) 2 (4%) 1 (2%)
Nephropathy 50 (100%) 50 (100%) 50 (100%) 50 (100%)
Pelvis, Inflammation, Acute 1 (2%)
Renal Tubule, Hyperplasia 2 (4%) 3 (6%) 6 (12%) 6 (12%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (50) (50) (50) (49)
Hemorrhage 1 (2%) 1 (2%)
Infiltration Cellular 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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