TDMS Study 05136-07 Pathology Tables
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:36:30
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 0000126-99-8
Lock Date: 05/04/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:36:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 19 21 23 27
Natural Death 1 1 1 2
Survivors
Terminal Sacrifice 29 28 26 21
Other 1
Animals Examined Microscopically 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Intestine Large, Colon (49) (49) (50) (49)
Intestine Large, Cecum (48) (49) (50) (49)
Intestine Small, Duodenum (49) (49) (50) (50)
Intestine Small, Jejunum (49) (49) (49) (48)
Intestine Small, Ileum (48) (49) (49) (48)
Liver (49) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (5) (6) (8) (11)
Lipoma 1 (13%)
Oral Mucosa (1) (1) (2) (1)
Buccal, Squamous Cell Papilloma 1 (100%)
Gingival, Squamous Cell Papilloma 1 (50%)
Pharyngeal, Squamous Cell Carcinoma 1 (50%)
Pharyngeal, Squamous Cell Papilloma 1 (100%) 1 (100%)
Pancreas (49) (50) (50) (50)
Salivary Glands (49) (50) (50) (50)
Stomach, Forestomach (49) (50) (50) (50)
Stomach, Glandular (49) (50) (50) (50)
Tongue (1) (4) (5) (12)
Squamous Cell Carcinoma 1 (25%) 2 (40%) 4 (33%)
Squamous Cell Papilloma 2 (50%) 1 (20%) 6 (50%)
Squamous Cell Papilloma, Multiple 1 (8%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:36:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Adenoma 2 (4%) 4 (8%) 2 (4%) 1 (2%)
Adrenal Medulla (49) (50) (50) (50)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 3 (6%) 3 (6%) 3 (6%) 2 (4%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (49) (50) (50) (50)
Adenoma 2 (4%) 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (48) (50) (50) (50)
Pars Distalis, Adenoma 36 (75%) 44 (88%) 44 (88%) 36 (72%)
Thyroid Gland (49) (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 7 (14%) 2 (4%) 5 (10%) 5 (10%)
C-Cell, Carcinoma 1 (2%) 2 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 3 (6%)
Follicular Cell, Carcinoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (46) (48) (46) (46)
Adenoma 2 (4%) 5 (10%) 2 (4%) 2 (4%)
Carcinoma 5 (10%) 4 (9%) 2 (4%)
Bilateral, Adenoma 1 (2%)
Bilateral, Carcinoma 1 (2%)
Ovary (49) (50) (50) (50)
Uterus (49) (50) (50) (50)
Deciduoma Malignant 1 (2%)
Granular Cell Tumor Malignant 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 6 (12%) 4 (8%) 5 (10%) 8 (16%)
Polyp Stromal, Multiple 1 (2%) 2 (4%)
Schwannoma Malignant 1 (2%)
Vagina (1)
Schwannoma Malignant, Metastatic, Uterus 1 (100%)
Page 3
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:36:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Lymph Node (1) (4) (4) (5)
Lymph Node, Bronchial (35) (34) (30) (36)
Lymph Node, Mandibular (44) (48) (37) (50)
Lymph Node, Mesenteric (49) (50) (49) (49)
Lymph Node, Mediastinal (44) (43) (43) (45)
Spleen (48) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Thymus (43) (41) (48) (46)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (50) (50)
Carcinoma 4 (8%) 5 (10%) 4 (8%) 4 (8%)
Fibroadenoma 19 (39%) 20 (40%) 21 (42%) 17 (34%)
Fibroadenoma, Multiple 5 (10%) 12 (24%) 15 (30%) 19 (38%)
Skin (49) (50) (50) (50)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Melanoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Chordoma 1 (2%)
Hemangiosarcoma 1 (2%)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Astrocytoma Benign 1 (2%)
Glioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:36:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Chordoma, Metastatic, Bone 1 (2%)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Nose (49) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Mesenchymal Tumor NOS 1 (2%)
Renal Tubule, Adenoma 2 (4%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (49) (50) (50) (50)
Leiomyosarcoma 1 (2%)
Schwannoma Malignant, Metastatic, Uterus 1 (2%)
Transitional Epithelium, Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(49) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 18 (37%) 18 (36%) 20 (40%) 26 (52%)
Mesothelioma Benign 1 (2%)
Mesothelioma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:36:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 50 50 49
Total Primary Neoplasms 119 137 144 156
Total Animals with Benign Neoplasms 44 48 49 46
Total Benign Neoplasms 87 102 103 112
Total Animals with Malignant Neoplasms 26 26 31 37
Total Malignant Neoplasms 31 35 41 43
Total Animals with Metastatic Neoplasms 1 2 1
Total Metastatic Neoplasm 2 2 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:36:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 34 40 41 41
Natural Death 3 1 4 5
Survivors
Terminal Sacrifice 13 9 5 4
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (49) (48) (49)
Intestine Large, Cecum (48) (49) (46) (48)
Polyp Adenomatous 1 (2%)
Intestine Small, Duodenum (50) (49) (49) (50)
Polyp Adenomatous 1 (2%) 1 (2%)
Intestine Small, Jejunum (48) (49) (46) (47)
Carcinoma 1 (2%)
Intestine Small, Ileum (49) (49) (46) (46)
Liver (50) (50) (49) (50)
Histiocytic Sarcoma 2 (4%)
Schwannoma Malignant, Metastatic, Heart 1 (2%)
Mesentery (16) (13) (18) (13)
Hemangioma 1 (8%)
Sarcoma 1 (6%)
Schwannoma Malignant 1 (6%)
Fat, Lipoma 1 (8%)
Oral Mucosa (2) (1) (7)
Buccal, Squamous Cell Papilloma 1 (14%)
Gingival, Squamous Cell Papilloma 1 (14%)
Pharyngeal, Squamous Cell Papilloma 2 (100%) 1 (100%) 2 (29%)
Pancreas (50) (50) (49) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Stomach, Glandular (49) (50) (49) (50)
Histiocytic Sarcoma 1 (2%)
Tongue (4) (8)
Squamous Cell Carcinoma 1 (25%) 2 (25%)
Squamous Cell Papilloma 3 (75%) 6 (75%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:36:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (1)
Aorta, Schwannoma Malignant, Metastatic,
Heart 1 (33%)
Heart (50) (50) (50) (50)
Schwannoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Adenoma 2 (4%) 1 (2%)
Adrenal Medulla (50) (50) (49) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Benign 14 (28%) 13 (26%) 11 (22%) 9 (18%)
Bilateral, Pheochromocytoma Benign 5 (10%) 7 (14%) 10 (20%) 9 (18%)
Islets, Pancreatic (50) (50) (49) (50)
Adenoma 3 (6%) 3 (6%) 2 (4%) 2 (4%)
Carcinoma 3 (6%) 5 (10%) 3 (6%) 1 (2%)
Parathyroid Gland (48) (49) (50) (50)
Adenoma 1 (2%)
Pituitary Gland (50) (49) (50) (49)
Pars Distalis, Adenoma 40 (80%) 40 (82%) 43 (86%) 39 (80%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (49) (50)
C-Cell, Adenoma 3 (6%) 6 (12%) 4 (8%) 7 (14%)
C-Cell, Carcinoma 2 (4%) 2 (4%) 2 (4%)
Follicular Cell, Adenoma 2 (4%) 2 (4%) 4 (8%)
Follicular Cell, Carcinoma 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (3)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (50) (50) (48) (50)
Adenoma 3 (6%) 3 (6%) 4 (8%) 1 (2%)
Carcinoma 3 (6%) 3 (6%) 4 (8%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Prostate (50) (50) (50) (50)
Adenoma 1 (2%) 3 (6%) 1 (2%)
Seminal Vesicle (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Page 8
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:36:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 23 (46%) 21 (42%) 15 (30%) 17 (34%)
Interstitial Cell, Adenoma 11 (22%) 13 (26%) 13 (26%) 12 (24%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (12) (18) (11) (15)
Iliac, Histiocytic Sarcoma 1 (7%)
Lymph Node, Bronchial (45) (31) (44) (43)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 2 (5%)
Lymph Node, Mandibular (47) (45) (44) (49)
Lymph Node, Mesenteric (50) (50) (48) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mediastinal (46) (47) (48) (47)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 2 (4%)
Spleen (50) (50) (49) (50)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sarcoma 1 (2%) 1 (2%)
Thymus (42) (42) (46) (48)
Histiocytic Sarcoma 1 (2%)
Thymoma Benign 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (30) (23) (30) (28)
Adenoma 1 (3%)
Carcinoma 1 (4%) 1 (3%)
Fibroadenoma 2 (7%) 1 (4%) 1 (4%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 2 (4%)
Histiocytic Sarcoma 1 (2%)
Keratoacanthoma 2 (4%) 4 (8%) 2 (4%) 4 (8%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibroma 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 2 (4%)
Page 9
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:36:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Melanoma Malignant 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%) 1 (2%)
Skeletal Muscle (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Glioma Malignant, Mixed Cell 1 (2%)
Glioma Malignant, Mixed 1 (2%)
Meninges, Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 3 (6%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (2%) 3 (6%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Histiocytic Sarcoma 2 (4%)
Melanoma Malignant, Metastatic, Skin 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinum, Schwannoma Malignant,
Metastatic, Heart 1 (2%)
Nose (50) (50) (49) (49)
Respiratory Epithelium, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1) (2)
Adenoma 1 (50%)
Carcinoma 1 (100%) 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:36:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Mesenchymal Tumor NOS 1 (2%)
Bilateral, Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 2 (4%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%)
Leukemia Mononuclear 33 (66%) 34 (68%) 29 (58%) 27 (54%)
Mesothelioma Malignant 1 (2%) 5 (10%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05136-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CHLOROPRENE Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:36:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.8 PPM 32 PPM 80 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50 50
Total Primary Neoplasms 166 181 176 180
Total Animals with Benign Neoplasms 50 50 50 48
Total Benign Neoplasms 118 123 121 133
Total Animals with Malignant Neoplasms 40 37 37 36
Total Malignant Neoplasms 47 58 55 46
Total Animals with Metastatic Neoplasms 1 2 2
Total Metastatic Neoplasm 1 5 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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