TDMS Study 05136-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest CHLOROPRENE DATE: 09/13/96
EXPERIMENT: 05136 TEST: 07 TIME: 16:04:16
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-05291 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 50522B
PATHOLOGIST: S. GRUMBEIN CAS: 0000126-99-8
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest CHLOROPRENE DATE: 09/13/96
EXPERIMENT: 05136 TEST: 07 TIME: 16:04:16
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05291 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 50522B
PATHOLOGIST: S. GRUMBEIN CAS: 0000126-99-8
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest CHLOROPRENE DATE: 09/13/96
EXPERIMENT: 05136 TEST: 07 TIME: 16:04:16
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05291 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 50522B
PATHOLOGIST: S. GRUMBEIN CAS: 0000126-99-8
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 9-8CHLOROPRENE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Lung Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)
Papilloma Squamous or Papilloma
Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Oral Mucosa Squamous Cell Papilloma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Prostate Adenoma
Thyroid Gland: C-Cell Adenoma
Thyroid Gland: Follicular Cell
Adenoma
Carcinoma or Adenoma
Tongue Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
All Organs Histiocytic Sarcoma
Mesothelioma: Benign, Malignant, NOS
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest CHLOROPRENE DATE: 09/13/96
EXPERIMENT: 05136 TEST: 07 TIME: 16:04:16
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05291 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 50522B
PATHOLOGIST: S. GRUMBEIN CAS: 0000126-99-8
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 9-8CHLOROPRENE
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Carcinoma
Carcinoma or Adenoma
Kidney: Renal Tubule Adenoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)
Papilloma Squamous or Papilloma
Squamous Cell Carcinoma
Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Thyroid Gland: Follicular Cell
Carcinoma or Adenoma
Tongue Squamous Cell Carcinoma
Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
Urinary Bladder Carcinoma
Carcinoma or Papilloma
Uterus Polyp Stromal
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/49 (2%) 0/50 (0%) | 2/49 (4%) 4/50 (8%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 11.0% 0.0% 10.0% 0.0% | 6.5% 12.1% 7.7% 4.8% |
|TERMINAL (d) | 1/13 (8%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 1/29 (3%) 2/28 (7%) 2/26 (8%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 637 --- 705 --- | 697 630 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.399N P=0.272N P=0.701N P=0.401N | P=0.348N P=0.347 P=0.649 P=0.594N |
|INCIDENTAL TUMOR | P=0.285N P=0.319N P=0.598N P=0.360N | P=0.274N P=0.329 P=0.644 P=0.536N |
|LOGISTIC REGRESSION | P=0.315N P=0.248N P=0.631N P=0.311N | P=0.287N P=0.349 P=0.659 P=0.549N |
|COCHRAN-ARMITAGE | P=0.236N | P=0.240N |
|FISHER EXACT | P=0.247N P=0.508N P=0.247N | P=0.349 P=0.684N P=0.492N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/50 (38%) 20/50 (40%) 21/49 (43%) 18/50 (36%) | 3/49 (6%) 3/50 (6%) 3/50 (6%) 3/50 (6%) |
|ADJUSTED (b) | 76.2% 78.0% 82.2% 100.0% | 10.3% 9.4% 10.9% 13.6% |
|TERMINAL (d) | 8/13 (62%) 4/9 (44%) 2/5 (40%) 4/4 (100%) | 3/29 (10%) 1/28 (4%) 2/26 (8%) 2/21 (10%) |
|FIRST INCIDENCE (DAYS) | 576 534 497 540 | 733 (T) 681 693 729 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.029 * P=0.280 P=0.027 * P=0.022 * | P=0.434 P=0.659 P=0.613 P=0.511 |
|INCIDENTAL TUMOR | P=0.461 P=0.565N P=0.198 P=0.362 | P=0.522 P=0.622N P=0.603 P=0.562 |
|LOGISTIC REGRESSION | P=0.312 P=0.444 P=0.150 P=0.237 | P=0.494 P=0.641N P=0.614 P=0.543 |
|COCHRAN-ARMITAGE | P=0.422N | P=0.586N |
|FISHER EXACT | P=0.500 P=0.387 P=0.500N | P=0.651N P=0.651N P=0.651N |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/50 (38%) 21/50 (42%) 21/49 (43%) 18/50 (36%) | 3/49 (6%) 4/50 (8%) 3/50 (6%) 3/50 (6%) |
|ADJUSTED (b) | 76.2% 82.4% 82.2% 100.0% | 10.3% 12.8% 10.9% 13.6% |
|TERMINAL (d) | 8/13 (62%) 5/9 (56%) 2/5 (40%) 4/4 (100%) | 3/29 (10%) 2/28 (7%) 2/26 (8%) 2/21 (10%) |
|FIRST INCIDENCE (DAYS) | 576 534 497 540 | 733 (T) 681 693 729 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.031 * P=0.214 P=0.027 * P=0.022 * | P=0.494 P=0.495 P=0.613 P=0.511 |
|INCIDENTAL TUMOR | P=0.474 P=0.508 P=0.198 P=0.362 | P=0.578 P=0.538 P=0.603 P=0.562 |
|LOGISTIC REGRESSION | P=0.336 P=0.356 P=0.150 P=0.237 | P=0.555 P=0.528 P=0.614 P=0.543 |
|COCHRAN-ARMITAGE | P=0.388N | P=0.513N |
|FISHER EXACT | P=0.419 P=0.387 P=0.500N | P=0.511 P=0.651N P=0.651N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 4/48 (8%) 1/50 (2%) | 2/46 (4%) 6/48 (13%) 2/46 (4%) 2/46 (4%) |
|ADJUSTED (b) | 12.3% 24.7% 21.6% 3.1% | 6.8% 18.1% 7.0% 5.3% |
|TERMINAL (d) | 1/13 (8%) 2/9 (22%) 0/5 (0%) 0/4 (0%) | 1/28 (4%) 3/27 (11%) 1/22 (5%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 534 613 497 601 | 721 525 601 609 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.451N P=0.567 P=0.331 P=0.440N | P=0.433N P=0.143 P=0.632 P=0.623 |
|INCIDENTAL TUMOR | P=0.293N P=0.534 P=0.559 P=0.378N | P=0.289N P=0.193 P=0.671 P=0.649N |
|LOGISTIC REGRESSION | P=0.239N P=0.655 P=0.533 P=0.285N | P=0.324N P=0.145 P=0.667 P=0.693N |
|COCHRAN-ARMITAGE | P=0.230N | P=0.321N |
|FISHER EXACT | P=0.661N P=0.477 P=0.309N | P=0.148 P=0.692N P=0.692N |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 4/48 (8%) 1/50 (2%) | 0/46 (0%) 6/48 (13%) 4/46 (9%) 2/46 (4%) |
|ADJUSTED (b) | 17.3% 24.8% 29.2% 25.0% | 0.0% 18.1% 13.3% 5.1% |
|TERMINAL (d) | 2/13 (15%) 2/9 (22%) 1/5 (20%) 1/4 (25%) | 0/28 (0%) 3/27 (11%) 2/22 (9%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 541 637 497 733 (T) | --- 630 544 572 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.551N P=0.553 P=0.237 P=0.649N | P=0.508 P=0.021 * P=0.049 * P=0.225 |
|INCIDENTAL TUMOR | P=0.457N P=0.531 P=0.378 P=0.608N | P=0.498N P=0.017 * P=0.102 P=0.321 |
|LOGISTIC REGRESSION | P=0.318N P=0.642 P=0.438 P=0.431N | P=0.555N P=0.019 * P=0.074 P=0.290 |
|COCHRAN-ARMITAGE | P=0.230N | P=0.566N |
|FISHER EXACT | P=0.661N P=0.477 P=0.309N | P=0.015 * P=0.058 P=0.247 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 6/50 (12%) 7/48 (15%) 2/50 (4%) | 2/46 (4%) 12/48 (25%) 5/46 (11%) 3/46 (7%) |
|ADJUSTED (b) | 28.6% 48.0% 43.3% 27.3% | 6.8% 34.0% 17.7% 7.3% |
|TERMINAL (d) | 3/13 (23%) 4/9 (44%) 1/5 (20%) 1/4 (25%) | 1/28 (4%) 6/27 (22%) 3/22 (14%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 534 613 497 601 | 721 525 544 572 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.418N P=0.463 P=0.196 P=0.399N | P=0.364N P=0.007 ** P=0.159 P=0.432 |
|INCIDENTAL TUMOR | P=0.245N P=0.420 P=0.421 P=0.324N | P=0.182N P=0.008 ** P=0.247 P=0.595 |
|LOGISTIC REGRESSION | P=0.153N P=0.600 P=0.437 P=0.172N | P=0.220N P=0.005 ** P=0.202 P=0.545 |
|COCHRAN-ARMITAGE | P=0.099N | P=0.217N |
|FISHER EXACT | P=0.620N P=0.468 P=0.134N | P=0.005 ** P=0.217 P=0.500 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 2/49 (4%) 2/50 (4%) | 2/49 (4%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 17.6% 18.1% 16.0% 20.0% | 6.6% 3.6% 3.8% 0.0% |
|TERMINAL (d) | 2/13 (15%) 1/9 (11%) 0/5 (0%) 0/4 (0%) | 1/29 (3%) 1/28 (4%) 1/26 (4%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 576 525 609 691 | 702 733 (T) 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.492 P=0.574 P=0.601 P=0.529 | P=0.227N P=0.501N P=0.541N P=0.291N |
|INCIDENTAL TUMOR | P=0.490N P=0.598 P=0.654N P=0.636N | P=0.209N P=0.469N P=0.551N P=0.235N |
|LOGISTIC REGRESSION | P=0.515N P=0.651 P=0.627N P=0.659N | P=0.209N P=0.483N P=0.536N P=0.263N |
|COCHRAN-ARMITAGE | P=0.393N | P=0.173N |
|FISHER EXACT | P=0.661N P=0.510N P=0.500N | P=0.492N P=0.492N P=0.242N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 5/50 (10%) 3/49 (6%) 1/50 (2%) | 1/49 (2%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 13.2% 29.1% 14.9% 5.3% | 3.4% 2.6% 2.6% 0.0% |
|TERMINAL (d) | 0/13 (0%) 1/9 (11%) 0/5 (0%) 0/4 (0%) | 1/29 (3%) 0/28 (0%) 0/26 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 489 603 609 651 | 733 (T) 679 601 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.337N P=0.315 P=0.488 P=0.444N | P=0.360N P=0.749N P=0.740 P=0.564N |
|INCIDENTAL TUMOR | P=0.123N P=0.478 P=0.608N P=0.196N | P=0.278N P=0.728N P=0.738N P=0.564N |
|LOGISTIC REGRESSION | P=0.181N P=0.346 P=0.652 P=0.306N | P=0.311N P=0.757N P=0.754N P=0.564N |
|COCHRAN-ARMITAGE | P=0.140N | P=0.314N |
|FISHER EXACT | P=0.357 P=0.651 P=0.309N | P=0.747N P=0.747N P=0.495N |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 8/50 (16%) 5/49 (10%) 3/50 (6%) | 3/49 (6%) 2/50 (4%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 28.4% 42.8% 28.6% 24.2% | 9.9% 6.1% 6.3% 0.0% |
|TERMINAL (d) | 2/13 (15%) 2/9 (22%) 0/5 (0%) 0/4 (0%) | 2/29 (7%) 1/28 (4%) 1/26 (4%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 489 525 609 651 | 702 679 601 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.452N P=0.300 P=0.433 P=0.583N | P=0.133N P=0.491N P=0.549N P=0.172N |
|INCIDENTAL TUMOR | P=0.137N P=0.435 P=0.562N P=0.241N | P=0.096N P=0.449N P=0.521N P=0.138N |
|LOGISTIC REGRESSION | P=0.194N P=0.369 P=0.601N P=0.331N | P=0.100N P=0.481N P=0.516N P=0.146N |
|COCHRAN-ARMITAGE | P=0.118N | P=0.090N |
|FISHER EXACT | P=0.387 P=0.514N P=0.243N | P=0.490N P=0.490N P=0.117N |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 1/50 (2%) 2/50 (4%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 5.9% 12.5% 16.0% | 0.0% 0.0% 0.0% 4.8% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- 700 721 625 | --- --- --- 609 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.065 P=0.500 P=0.388 P=0.144 | P=0.044 * (e) (e) P=0.240 |
|INCIDENTAL TUMOR | P=0.213 P=0.592 P=0.500 P=0.278 | P=0.096 (e) (e) P=0.328 |
|LOGISTIC REGRESSION | P=0.102 P=0.484 P=0.383 P=0.190 | P=0.041 * (e) (e) P=0.247 |
|COCHRAN-ARMITAGE | P=0.176 | P=0.043 * |
|FISHER EXACT | P=0.500 P=0.500 P=0.247 | (e) (e) P=0.253 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 3/49 (6%) 3/50 (6%) | 1/49 (2%) 0/50 (0%) 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 6.9% 0.0% 14.2% 52.9% | 3.4% 0.0% 0.0% 9.6% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 2/4 (50%) | 1/29 (3%) 0/28 (0%) 0/26 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 616 --- 505 660 | 733 (T) --- --- 613 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.092 P=0.235N P=0.381 P=0.254 | P=0.046 * P=0.507N P=0.522N P=0.246 |
|INCIDENTAL TUMOR | P=0.179 P=0.311N P=0.619 P=0.334 | P=0.084 P=0.507N P=0.522N P=0.317 |
|LOGISTIC REGRESSION | P=0.200 P=0.233N P=0.563 P=0.370 | P=0.066 P=0.507N P=0.522N P=0.314 |
|COCHRAN-ARMITAGE | P=0.230 | P=0.066 |
|FISHER EXACT | P=0.247N P=0.490 P=0.500 | P=0.495N P=0.495N P=0.316 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/49 (2%) 4/50 (8%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 17.9% 6.7% 35.1% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/13 (0%) 1/9 (11%) 0/5 (0%) 1/4 (25%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- 702 667 540 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007 ** P=0.173 P=0.433 P=0.021 * | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.026 * P=0.245 P=0.500 P=0.046 * | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.023 * P=0.200 P=0.452 P=0.052 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.044 * | (e) |
|FISHER EXACT | P=0.247 P=0.495 P=0.059 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 4/49 (8%) 6/50 (12%) | 1/49 (2%) 0/50 (0%) 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 6.9% 17.9% 19.9% 59.3% | 3.4% 0.0% 0.0% 9.6% |
|TERMINAL (d) | 0/13 (0%) 1/9 (11%) 0/5 (0%) 2/4 (50%) | 1/29 (3%) 0/28 (0%) 0/26 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 616 702 505 540 | 733 (T) --- --- 613 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.009 ** P=0.639 P=0.224 P=0.040 * | P=0.046 * P=0.507N P=0.522N P=0.246 |
|INCIDENTAL TUMOR | P=0.040 * P=0.644 P=0.442 P=0.088 | P=0.084 P=0.507N P=0.522N P=0.317 |
|LOGISTIC REGRESSION | P=0.039 * P=0.684 P=0.366 P=0.094 | P=0.066 P=0.507N P=0.522N P=0.314 |
|COCHRAN-ARMITAGE | P=0.058 | P=0.066 |
|FISHER EXACT | P=0.691N P=0.329 P=0.134 | P=0.495N P=0.495N P=0.316 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 1/50 (2%) 0/50 (0%) | 4/49 (8%) 5/50 (10%) 4/50 (8%) 4/50 (8%) |
|ADJUSTED (b) | 0.0% 11.1% 12.5% 0.0% | 12.1% 15.1% 13.4% 14.1% |
|TERMINAL (d) | 0/13 (0%) 1/9 (11%) 0/5 (0%) 0/4 (0%) | 2/29 (7%) 2/28 (7%) 2/26 (8%) 2/21 (10%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 721 --- | 661 671 634 609 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.703 P=0.427 P=0.388 (e) | P=0.486 P=0.527 P=0.576 P=0.527 |
|INCIDENTAL TUMOR | P=0.658N P=0.427 P=0.500 (e) | P=0.485N P=0.608 P=0.588 P=0.631N |
|LOGISTIC REGRESSION | P=0.729 P=0.427 P=0.383 (e) | P=0.546N P=0.518 P=0.628 P=0.643 |
|COCHRAN-ARMITAGE | P=0.559N | P=0.510N |
|FISHER EXACT | P=0.500 P=0.500 (e) | P=0.513 P=0.631N P=0.631N |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 1/50 (2%) 0/50 (0%) | 4/49 (8%) 5/50 (10%) 4/50 (8%) 4/50 (8%) |
|ADJUSTED (b) | 0.0% 11.1% 12.5% 0.0% | 12.1% 15.1% 13.4% 14.1% |
|TERMINAL (d) | 0/13 (0%) 1/9 (11%) 0/5 (0%) 0/4 (0%) | 2/29 (7%) 2/28 (7%) 2/26 (8%) 2/21 (10%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 721 --- | 661 671 634 609 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.703 P=0.427 P=0.388 (e) | P=0.486 P=0.527 P=0.576 P=0.527 |
|INCIDENTAL TUMOR | P=0.658N P=0.427 P=0.500 (e) | P=0.485N P=0.608 P=0.588 P=0.631N |
|LOGISTIC REGRESSION | P=0.729 P=0.427 P=0.383 (e) | P=0.546N P=0.518 P=0.628 P=0.643 |
|COCHRAN-ARMITAGE | P=0.559N | P=0.510N |
|FISHER EXACT | P=0.500 P=0.500 (e) | P=0.513 P=0.631N P=0.631N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 1/50 (2%) | 24/49 (49%) 32/50 (64%) 36/50 (72%) 36/50 (72%) |
|ADJUSTED (b) | 10.2% 4.2% 0.0% 25.0% | 65.4% 86.0% 85.3% 89.7% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 1/4 (25%) | 17/29 (59%) 23/28 (82%) 20/26 (77%) 17/21 (81%) |
|FIRST INCIDENCE (DAYS) | 658 665 --- 733 (T) | 366 302 470 433 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.651N P=0.501N P=0.326N P=0.730 | P<0.001 ** P=0.087 P=0.009 ** P=0.002 ** |
|INCIDENTAL TUMOR | P=0.488N P=0.339N P=0.235N P=0.546N | P=0.007 ** P=0.097 P=0.012 * P=0.008 ** |
|LOGISTIC REGRESSION | P=0.567N P=0.513N P=0.301N P=0.663N | P=0.005 ** P=0.130 P=0.011 * P=0.009 ** |
|COCHRAN-ARMITAGE | P=0.447N | P=0.025 * |
|FISHER EXACT | P=0.500N P=0.247N P=0.500N | P=0.096 P=0.016 * P=0.016 * |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 1/50 (2%) | 24/49 (49%) 32/50 (64%) 36/50 (72%) 36/50 (72%) |
|ADJUSTED (b) | 10.2% 4.2% 12.5% 25.0% | 65.4% 86.0% 85.3% 89.7% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 1/4 (25%) | 17/29 (59%) 23/28 (82%) 20/26 (77%) 17/21 (81%) |
|FIRST INCIDENCE (DAYS) | 658 665 721 733 (T) | 366 302 470 433 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.602 P=0.501N P=0.649N P=0.730 | P<0.001 ** P=0.087 P=0.009 ** P=0.002 ** |
|INCIDENTAL TUMOR | P=0.483N P=0.339N P=0.500N P=0.546N | P=0.007 ** P=0.097 P=0.012 * P=0.008 ** |
|LOGISTIC REGRESSION | P=0.612N P=0.513N P=0.634N P=0.663N | P=0.005 ** P=0.130 P=0.011 * P=0.009 ** |
|COCHRAN-ARMITAGE | P=0.457N | P=0.025 * |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | P=0.096 P=0.016 * P=0.016 * |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 1/50 (2%) 1/50 (2%) | 28/49 (57%) 34/50 (68%) 36/50 (72%) 36/50 (72%) |
|ADJUSTED (b) | 10.2% 14.8% 12.5% 25.0% | 72.7% 89.1% 85.3% 89.7% |
|TERMINAL (d) | 0/13 (0%) 1/9 (11%) 0/5 (0%) 1/4 (25%) | 19/29 (66%) 24/28 (86%) 20/26 (77%) 17/21 (81%) |
|FIRST INCIDENCE (DAYS) | 658 665 721 733 (T) | 366 302 470 433 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.631 P=0.659 P=0.649N P=0.730 | P=0.006 ** P=0.177 P=0.045 * P=0.011 * |
|INCIDENTAL TUMOR | P=0.448N P=0.604N P=0.500N P=0.546N | P=0.041 * P=0.213 P=0.060 P=0.050 |
|LOGISTIC REGRESSION | P=0.549N P=0.677 P=0.634N P=0.663N | P=0.039 * P=0.235 P=0.068 P=0.059 |
|COCHRAN-ARMITAGE | P=0.363N | P=0.115 |
|FISHER EXACT | P=0.691N P=0.500N P=0.500N | P=0.182 P=0.091 P=0.091 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 4/50 (8%) 10/50 (20%) | 1/49 (2%) 2/50 (4%) 2/50 (4%) 7/50 (14%) |
|ADJUSTED (b) | 0.0% 13.8% 25.4% 71.7% | 3.0% 6.2% 7.7% 29.5% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 2/4 (50%) | 0/29 (0%) 1/28 (4%) 2/26 (8%) 5/21 (24%) |
|FIRST INCIDENCE (DAYS) | --- 701 620 539 | 687 681 733 (T) 660 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.198 P=0.029 * P<0.001 ** | P=0.002 ** P=0.516 P=0.464 P=0.013 * |
|INCIDENTAL TUMOR | P<0.001 ** P=0.343 P=0.070 P<0.001 ** | P=0.004 ** P=0.574 P=0.449 P=0.024 * |
|LOGISTIC REGRESSION | P<0.001 ** P=0.217 P=0.040 * P<0.001 ** | P=0.003 ** P=0.508 P=0.469 P=0.020 * |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.007 ** |
|FISHER EXACT | P=0.247 P=0.059 P<0.001 ** | P=0.508 P=0.508 P=0.032 * |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/49 (0%) 1/50 (2%) 3/50 (6%) 4/50 (8%) |
|ADJUSTED (b) | 0.0% 0.0% 4.0% 11.3% | 0.0% 3.2% 9.8% 14.8% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 2/26 (8%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- 609 649 | --- 721 588 671 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.051 (e) P=0.439 P=0.185 | P=0.017 * P=0.507 P=0.109 P=0.047 * |
|INCIDENTAL TUMOR | P=0.097 (e) P=0.521 P=0.316 | P=0.042 * P=0.567 P=0.127 P=0.082 |
|LOGISTIC REGRESSION | P=0.067 (e) P=0.521 P=0.200 | P=0.028 * P=0.510 P=0.121 P=0.055 |
|COCHRAN-ARMITAGE | P=0.077 | P=0.034 * |
|FISHER EXACT | (e) P=0.500 P=0.247 | P=0.505 P=0.125 P=0.061 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 5/50 (10%) 12/50 (24%) | 1/49 (2%) 3/50 (6%) 5/50 (10%) 11/50 (22%) |
|ADJUSTED (b) | 0.0% 13.8% 28.4% 74.9% | 3.0% 9.2% 17.4% 40.8% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 2/4 (50%) | 0/29 (0%) 1/28 (4%) 4/26 (15%) 6/21 (29%) |
|FIRST INCIDENCE (DAYS) | --- 701 609 539 | 687 681 588 660 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.198 P=0.013 * P<0.001 ** | P<0.001 ** P=0.324 P=0.086 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.343 P=0.039 * P<0.001 ** | P<0.001 ** P=0.393 P=0.093 P=0.002 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.217 P=0.022 * P<0.001 ** | P<0.001 ** P=0.315 P=0.093 P=0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.247 P=0.028 * P<0.001 ** | P=0.316 P=0.107 P=0.002 ** |
|=================================================================================================================================|
| |
|Oral Mucosa |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) 4/50 (8%) | 1/49 (2%) 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 13.8% 4.3% 15.5% | 3.0% 2.7% 3.8% 4.8% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 1/26 (4%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | --- 701 620 540 | 687 681 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.019 * P=0.198 P=0.447 P=0.048 * | P=0.577 P=0.741N P=0.738 P=0.701 |
|INCIDENTAL TUMOR | P=0.062 P=0.343 P=0.521 P=0.099 | P=0.642 P=0.688N P=0.723 P=0.762N |
|LOGISTIC REGRESSION | P=0.034 * P=0.217 P=0.508 P=0.065 | P=0.632 P=0.758N P=0.749 P=0.746 |
|COCHRAN-ARMITAGE | P=0.043 * | P=0.651N |
|FISHER EXACT | P=0.247 P=0.500 P=0.059 | P=0.747N P=0.747N P=0.747N |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 40/50 (80%) 40/49 (82%) 43/50 (86%) 39/49 (80%) | 36/48 (75%) 44/50 (88%) 44/50 (88%) 36/50 (72%) |
|ADJUSTED (b) | 92.2% 97.0% 100.0% 96.3% | 89.8% 97.7% 93.6% 83.3% |
|TERMINAL (d) | 10/13 (77%) 8/9 (89%) 5/5 (100%) 3/4 (75%) | 24/28 (86%) 27/28 (96%) 23/26 (88%) 14/21 (67%) |
|FIRST INCIDENCE (DAYS) | 469 357 460 470 | 553 352 450 463 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.018 * P=0.340 P=0.009 ** P=0.036 * | P=0.198 P=0.150 P=0.051 P=0.171 |
|INCIDENTAL TUMOR | P=0.491 P=0.590 P=0.231 P=0.507 | P=0.214N P=0.073 P=0.027 * P=0.532N |
|LOGISTIC REGRESSION | P=0.508 P=0.526 P=0.263 P=0.466 | P=0.193N P=0.061 P=0.043 * P=0.549N |
|COCHRAN-ARMITAGE | P=0.506N | P=0.160N |
|FISHER EXACT | P=0.520 P=0.298 P=0.579N | P=0.080 P=0.080 P=0.458N |
|=================================================================================================================================|
| |
|Prostate |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 3/50 (6%) 1/50 (2%) | |
|ADJUSTED (b) | 0.0% 11.1% 35.0% 5.9% | |
|TERMINAL (d) | 0/13 (0%) 1/9 (11%) 1/5 (20%) 0/4 (0%) | |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 679 660 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.182 P=0.427 P=0.038 * P=0.458 | |
|INCIDENTAL TUMOR | P=0.337 P=0.427 P=0.069 P=0.569 | |
|LOGISTIC REGRESSION | P=0.263 P=0.427 P=0.045 * P=0.465 | |
|COCHRAN-ARMITAGE | P=0.448 | |
|FISHER EXACT | P=0.500 P=0.121 P=0.500 | |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/49 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 8.7% 0.0% 0.0% | 0.0% 0.0% 3.8% 0.0% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 1/26 (4%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- 609 --- --- | --- --- 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.475N P=0.236 (e) (e) | P=0.752 (e) P=0.478 (e) |
|INCIDENTAL TUMOR | P=0.357N P=0.250 (e) (e) | P=0.752 (e) P=0.478 (e) |
|LOGISTIC REGRESSION | P=0.412N P=0.234 (e) (e) | P=0.752 (e) P=0.478 (e) |
|COCHRAN-ARMITAGE | P=0.382N | P=0.780 |
|FISHER EXACT | P=0.247 (e) (e) | (e) P=0.505 (e) |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, |
| malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/49 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 3.6% 8.7% 0.0% 0.0% | 0.0% 0.0% 3.8% 0.0% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 1/26 (4%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 637 609 --- --- | --- --- 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.277N P=0.505 P=0.577N P=0.557N | P=0.752 (e) P=0.478 (e) |
|INCIDENTAL TUMOR | P=0.180N P=0.477 P=0.479N P=0.500N | P=0.752 (e) P=0.478 (e) |
|LOGISTIC REGRESSION | P=0.218N P=0.497 P=0.511N P=0.510N | P=0.752 (e) P=0.478 (e) |
|COCHRAN-ARMITAGE | P=0.200N | P=0.780 |
|FISHER EXACT | P=0.500 P=0.500N P=0.500N | (e) P=0.505 (e) |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 5/50 (10%) 3/50 (6%) 5/50 (10%) | 0/49 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 14.9% 20.8% 12.8% 43.5% | 0.0% 0.0% 3.8% 4.8% |
|TERMINAL (d) | 1/13 (8%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 1/26 (4%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 637 609 540 625 | --- --- 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.134 P=0.361 P=0.457 P=0.116 | P=0.209 (e) P=0.478 P=0.436 |
|INCIDENTAL TUMOR | P=0.423 P=0.387 P=0.658 P=0.399 | P=0.209 (e) P=0.478 P=0.436 |
|LOGISTIC REGRESSION | P=0.273 P=0.341 P=0.644 P=0.201 | P=0.209 (e) P=0.478 P=0.436 |
|COCHRAN-ARMITAGE | P=0.376 | P=0.277 |
|FISHER EXACT | P=0.357 P=0.661N P=0.357 | (e) P=0.505 P=0.505 |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 1/50 (2%) | 0/49 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 15.3% 0.0% 3.2% | 0.0% 0.0% 3.8% 0.0% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 1/26 (4%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- 700 --- 603 | --- --- 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.416 P=0.211 (e) P=0.476 | P=0.752 (e) P=0.478 (e) |
|INCIDENTAL TUMOR | P=0.626 P=0.343 (e) P=0.500 | P=0.752 (e) P=0.478 (e) |
|LOGISTIC REGRESSION | P=0.514 P=0.204 (e) P=0.524 | P=0.752 (e) P=0.478 (e) |
|COCHRAN-ARMITAGE | P=0.591 | P=0.780 |
|FISHER EXACT | P=0.247 (e) P=0.500 | (e) P=0.505 (e) |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 1/50 (2%) 2/50 (4%) | 2/49 (4%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 10.1% 15.3% 12.5% 5.2% | 6.9% 0.0% 7.7% 0.0% |
|TERMINAL (d) | 1/13 (8%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 2/29 (7%) 0/28 (0%) 2/26 (8%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 576 700 721 307 | 733 (T) --- 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.390 P=0.635 P=0.700N P=0.574 | P=0.347N P=0.246N P=0.656 P=0.311N |
|INCIDENTAL TUMOR | P=0.502N P=0.677N P=0.593N P=0.627N | P=0.347N P=0.246N P=0.656 P=0.311N |
|LOGISTIC REGRESSION | P=0.556N P=0.679 P=0.599N P=0.561N | P=0.347N P=0.246N P=0.656 P=0.311N |
|COCHRAN-ARMITAGE | P=0.616N | P=0.267N |
|FISHER EXACT | P=0.691N P=0.500N P=0.691N | P=0.242N P=0.684N P=0.242N |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/49 (4%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 7.7% 0.0% 0.0% 0.0% | 6.9% 0.0% 3.8% 0.0% |
|TERMINAL (d) | 1/13 (8%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 2/29 (7%) 0/28 (0%) 1/26 (4%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- --- | 733 (T) --- 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.574N P=0.573N P=0.690N P=0.734N | P=0.294N P=0.246N P=0.538N P=0.311N |
|INCIDENTAL TUMOR | P=0.574N P=0.573N P=0.690N P=0.734N | P=0.294N P=0.246N P=0.538N P=0.311N |
|LOGISTIC REGRESSION | P=0.574N P=0.573N P=0.690N P=0.734N | P=0.294N P=0.246N P=0.538N P=0.311N |
|COCHRAN-ARMITAGE | P=0.406N | P=0.233N |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | P=0.242N P=0.492N P=0.242N |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) 1/50 (2%) | 2/49 (4%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 10.1% 0.0% 12.5% 2.0% | 6.9% 0.0% 3.8% 0.0% |
|TERMINAL (d) | 1/13 (8%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 2/29 (7%) 0/28 (0%) 1/26 (4%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 576 --- 721 307 | 733 (T) --- 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.594 P=0.280N P=0.700N P=0.637N | P=0.294N P=0.246N P=0.538N P=0.311N |
|INCIDENTAL TUMOR | P=0.457N P=0.319N P=0.593N P=0.360N | P=0.294N P=0.246N P=0.538N P=0.311N |
|LOGISTIC REGRESSION | P=0.375N P=0.241N P=0.599N P=0.332N | P=0.294N P=0.246N P=0.538N P=0.311N |
|COCHRAN-ARMITAGE | P=0.574N | P=0.233N |
|FISHER EXACT | P=0.247N P=0.500N P=0.500N | P=0.242N P=0.492N P=0.242N |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 2/50 (4%) 4/50 (8%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 11.7% 15.6% 10.1% 34.1% | 0.0% 0.0% 0.0% 4.8% |
|TERMINAL (d) | 1/13 (8%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 657 609 540 625 | --- --- --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.145 P=0.336 P=0.514 P=0.122 | P=0.162 (e) (e) P=0.436 |
|INCIDENTAL TUMOR | P=0.388 P=0.362 P=0.673 P=0.356 | P=0.162 (e) (e) P=0.436 |
|LOGISTIC REGRESSION | P=0.265 P=0.324 P=0.646 P=0.195 | P=0.162 (e) (e) P=0.436 |
|COCHRAN-ARMITAGE | P=0.359 | P=0.208 |
|FISHER EXACT | P=0.339 P=0.691N P=0.339 | (e) (e) P=0.505 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Lipoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 10.4% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 4.8% |
|TERMINAL (d) | 1/13 (8%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 613 --- --- --- | --- --- --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.277N P=0.287N P=0.392N P=0.393N | P=0.162 (e) (e) P=0.436 |
|INCIDENTAL TUMOR | P=0.244N P=0.319N P=0.325N P=0.360N | P=0.162 (e) (e) P=0.436 |
|LOGISTIC REGRESSION | P=0.217N P=0.244N P=0.292N P=0.290N | P=0.162 (e) (e) P=0.436 |
|COCHRAN-ARMITAGE | P=0.185N | P=0.208 |
|FISHER EXACT | P=0.247N P=0.247N P=0.247N | (e) (e) P=0.505 |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 3/50 (6%) 5/50 (10%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 11.7% 15.6% 12.8% 43.5% | 0.0% 0.0% 0.0% 4.8% |
|TERMINAL (d) | 1/13 (8%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 657 609 540 625 | --- --- --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.063 P=0.336 P=0.312 P=0.051 | P=0.162 (e) (e) P=0.436 |
|INCIDENTAL TUMOR | P=0.245 P=0.362 P=0.483 P=0.246 | P=0.162 (e) (e) P=0.436 |
|LOGISTIC REGRESSION | P=0.145 P=0.324 P=0.477 P=0.094 | P=0.162 (e) (e) P=0.436 |
|COCHRAN-ARMITAGE | P=0.215 | P=0.208 |
|FISHER EXACT | P=0.339 P=0.500 P=0.218 | (e) (e) P=0.505 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 3/50 (6%) 5/50 (10%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 11.7% 15.6% 12.8% 43.5% | 0.0% 0.0% 0.0% 4.8% |
|TERMINAL (d) | 1/13 (8%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | 657 609 540 625 | --- --- --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.063 P=0.336 P=0.312 P=0.051 | P=0.162 (e) (e) P=0.436 |
|INCIDENTAL TUMOR | P=0.245 P=0.362 P=0.483 P=0.246 | P=0.162 (e) (e) P=0.436 |
|LOGISTIC REGRESSION | P=0.145 P=0.324 P=0.477 P=0.094 | P=0.162 (e) (e) P=0.436 |
|COCHRAN-ARMITAGE | P=0.215 | P=0.208 |
|FISHER EXACT | P=0.339 P=0.500 P=0.218 | (e) (e) P=0.505 |
|=================================================================================================================================|
| |
|Skin: Sebaceous Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 7.7% 13.1% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/13 (8%) 1/9 (11%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 541 --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.347N P=0.415 P=0.690N P=0.734N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.315N P=0.430 P=0.690N P=0.734N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.240N P=0.490 P=0.690N P=0.734N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.200N | (e) |
|FISHER EXACT | P=0.500 P=0.500N P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 34/50 (68%) 34/50 (68%) 28/50 (56%) 29/50 (58%) | |
|ADJUSTED (b) | 90.7% 100.0% 93.7% 100.0% | |
|TERMINAL (d) | 10/13 (77%) 9/9 (100%) 4/5 (80%) 4/4 (100%) | |
|FIRST INCIDENCE (DAYS) | 469 525 460 463 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.061 P=0.289 P=0.154 P=0.077 | |
|INCIDENTAL TUMOR | P=0.363N P=0.366 P=0.257N P=0.446N | |
|LOGISTIC REGRESSION | P=0.348N P=0.529 P=0.238N P=0.448N | |
|COCHRAN-ARMITAGE | P=0.140N | |
|FISHER EXACT | P=0.585N P=0.151N P=0.204N | |
|=================================================================================================================================|
| |
|Thymus |
| Thymoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/42 (2%) 0/42 (0%) 0/46 (0%) 2/48 (4%) | 0/43 (0%) 0/41 (0%) 0/48 (0%) 0/46 (0%) |
|ADJUSTED (b) | 10.0% 0.0% 0.0% 12.3% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/10 (10%) 0/7 (0%) 0/5 (0%) 0/4 (0%) | 0/26 (0%) 0/22 (0%) 0/25 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- 649 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.112 P=0.571N P=0.638N P=0.325 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.175 P=0.571N P=0.638N P=0.471 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.165 P=0.571N P=0.638N P=0.418 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.240 | (e) |
|FISHER EXACT | P=0.500N P=0.477N P=0.550 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Thymus |
| Thymoma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/42 (2%) 0/42 (0%) 0/46 (0%) 2/48 (4%) | 0/43 (0%) 0/41 (0%) 1/48 (2%) 0/46 (0%) |
|ADJUSTED (b) | 10.0% 0.0% 0.0% 12.3% | 0.0% 0.0% 2.3% 0.0% |
|TERMINAL (d) | 1/10 (10%) 0/7 (0%) 0/5 (0%) 0/4 (0%) | 0/26 (0%) 0/22 (0%) 0/25 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- 649 | --- --- 585 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.112 P=0.571N P=0.638N P=0.325 | P=0.777 (e) P=0.500 (e) |
|INCIDENTAL TUMOR | P=0.175 P=0.571N P=0.638N P=0.471 | P=0.677N (e) P=0.571 (e) |
|LOGISTIC REGRESSION | P=0.165 P=0.571N P=0.638N P=0.418 | P=0.785N (e) P=0.578 (e) |
|COCHRAN-ARMITAGE | P=0.240 | P=0.783N |
|FISHER EXACT | P=0.500N P=0.477N P=0.550 | (e) P=0.527 (e) |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 6/50 (12%) 4/49 (8%) 7/50 (14%) | 7/49 (14%) 3/50 (6%) 5/50 (10%) 5/50 (10%) |
|ADJUSTED (b) | 18.0% 21.6% 44.0% 55.3% | 20.3% 10.7% 16.2% 19.1% |
|TERMINAL (d) | 2/13 (15%) 0/9 (0%) 1/5 (20%) 1/4 (25%) | 3/29 (10%) 3/28 (11%) 3/26 (12%) 3/21 (14%) |
|FIRST INCIDENCE (DAYS) | 616 541 609 549 | 622 733 (T) 590 463 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.024 * P=0.227 P=0.172 P=0.019 * | P=0.481 P=0.162N P=0.460N P=0.538N |
|INCIDENTAL TUMOR | P=0.140 P=0.274 P=0.300 P=0.078 | P=0.527N P=0.154N P=0.433N P=0.367N |
|LOGISTIC REGRESSION | P=0.092 P=0.233 P=0.287 P=0.078 | P=0.516N P=0.145N P=0.391N P=0.380N |
|COCHRAN-ARMITAGE | P=0.183 | P=0.485N |
|FISHER EXACT | P=0.243 P=0.489 P=0.159 | P=0.151N P=0.365N P=0.365N |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 2/49 (4%) 0/50 (0%) | 1/49 (2%) 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 9.9% 10.8% 11.8% 0.0% | 3.4% 7.1% 2.7% 0.0% |
|TERMINAL (d) | 1/13 (8%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 1/29 (3%) 2/28 (7%) 0/26 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 571 679 652 --- | 733 (T) 733 (T) 608 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.312N P=0.648 P=0.520 P=0.378N | P=0.289N P=0.488 P=0.737 P=0.564N |
|INCIDENTAL TUMOR | P=0.166N P=0.677N P=0.619 P=0.360N | P=0.247N P=0.488 P=0.738N P=0.564N |
|LOGISTIC REGRESSION | P=0.206N P=0.685 P=0.636 P=0.262N | P=0.248N P=0.488 P=0.755N P=0.564N |
|COCHRAN-ARMITAGE | P=0.158N | P=0.233N |
|FISHER EXACT | P=0.691N P=0.684 P=0.247N | P=0.508 P=0.747N P=0.495N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 7/50 (14%) 6/49 (12%) 7/50 (14%) | 8/49 (16%) 5/50 (10%) 6/50 (12%) 5/50 (10%) |
|ADJUSTED (b) | 27.3% 25.8% 50.6% 55.3% | 23.4% 17.9% 18.4% 19.1% |
|TERMINAL (d) | 3/13 (23%) 0/9 (0%) 1/5 (20%) 1/4 (25%) | 4/29 (14%) 5/28 (18%) 3/26 (12%) 3/21 (14%) |
|FIRST INCIDENCE (DAYS) | 571 541 609 549 | 622 733 (T) 590 463 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.076 P=0.333 P=0.148 P=0.070 | P=0.493N P=0.282N P=0.474N P=0.440N |
|INCIDENTAL TUMOR | P=0.326 P=0.398 P=0.285 P=0.199 | P=0.345N P=0.275N P=0.426N P=0.281N |
|LOGISTIC REGRESSION | P=0.240 P=0.366 P=0.285 P=0.240 | P=0.333N P=0.249N P=0.392N P=0.282N |
|COCHRAN-ARMITAGE | P=0.396 | P=0.302N |
|FISHER EXACT | P=0.380 P=0.486 P=0.380 | P=0.264N P=0.371N P=0.264N |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 2/49 (4%) 4/50 (8%) | 1/49 (2%) 1/50 (2%) 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 13.5% 22.5% 33.1% | 3.4% 3.2% 0.0% 12.0% |
|TERMINAL (d) | 0/13 (0%) 1/9 (11%) 1/5 (20%) 1/4 (25%) | 1/29 (3%) 0/28 (0%) 0/26 (0%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | --- 597 569 307 | 733 (T) 721 --- 705 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.013 * P=0.202 P=0.117 P=0.027 * | P=0.090 P=0.760 P=0.522N P=0.229 |
|INCIDENTAL TUMOR | P=0.043 * P=0.168 P=0.145 P=0.075 | P=0.144 P=0.728N P=0.522N P=0.306 |
|LOGISTIC REGRESSION | P=0.063 P=0.232 P=0.201 P=0.089 | P=0.104 P=0.753N P=0.522N P=0.252 |
|COCHRAN-ARMITAGE | P=0.054 | P=0.142 |
|FISHER EXACT | P=0.247 P=0.242 P=0.059 | P=0.747N P=0.495N P=0.316 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/49 (4%) 1/50 (2%) | 0/49 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 9.1% 4.8% | 0.0% 0.0% 3.8% 5.5% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 1/26 (4%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 622 646 | --- --- 733 (T) 617 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.260 (e) P=0.172 P=0.465 | P=0.059 (e) P=0.478 P=0.222 |
|INCIDENTAL TUMOR | P=0.342 (e) P=0.249 P=0.569 | P=0.104 (e) P=0.478 P=0.324 |
|LOGISTIC REGRESSION | P=0.299 (e) P=0.234 P=0.480 | P=0.080 (e) P=0.478 P=0.251 |
|COCHRAN-ARMITAGE | P=0.307 | P=0.078 |
|FISHER EXACT | (e) P=0.242 P=0.500 | (e) P=0.505 P=0.253 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 4/49 (8%) 5/50 (10%) | 1/49 (2%) 1/50 (2%) 1/50 (2%) 5/50 (10%) |
|ADJUSTED (b) | 0.0% 13.5% 29.5% 36.3% | 3.4% 3.2% 3.8% 16.8% |
|TERMINAL (d) | 0/13 (0%) 1/9 (11%) 1/5 (20%) 1/4 (25%) | 1/29 (3%) 0/28 (0%) 1/26 (4%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | --- 597 569 307 | 733 (T) 721 733 (T) 617 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007 ** P=0.202 P=0.021 * P=0.014 * | P=0.010 * P=0.760 P=0.738 P=0.072 |
|INCIDENTAL TUMOR | P=0.027 * P=0.168 P=0.039 * P=0.046 * | P=0.028 * P=0.728N P=0.738 P=0.133 |
|LOGISTIC REGRESSION | P=0.029 * P=0.232 P=0.050 P=0.044 * | P=0.017 * P=0.753N P=0.738 P=0.098 |
|COCHRAN-ARMITAGE | P=0.029 * | P=0.022 * |
|FISHER EXACT | P=0.247 P=0.056 P=0.028 * | P=0.747N P=0.747N P=0.107 |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/49 (0%) 1/50 (2%) 2/50 (4%) 4/50 (8%) |
|ADJUSTED (b) | 0.0% 0.0% 4.0% 11.3% | 0.0% 3.2% 6.1% 14.8% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 1/26 (4%) 1/21 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- 609 649 | --- 721 588 671 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.051 (e) P=0.439 P=0.185 | P=0.014 * P=0.507 P=0.225 P=0.047 * |
|INCIDENTAL TUMOR | P=0.097 (e) P=0.521 P=0.316 | P=0.038 * P=0.567 P=0.262 P=0.082 |
|LOGISTIC REGRESSION | P=0.067 (e) P=0.521 P=0.200 | P=0.023 * P=0.510 P=0.248 P=0.055 |
|COCHRAN-ARMITAGE | P=0.077 | P=0.026 * |
|FISHER EXACT | (e) P=0.500 P=0.247 | P=0.505 P=0.253 P=0.061 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 4/50 (8%) 8/50 (16%) | 0/49 (0%) 3/50 (6%) 3/50 (6%) 11/50 (22%) |
|ADJUSTED (b) | 0.0% 0.0% 25.2% 70.2% | 0.0% 9.2% 9.8% 40.8% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 2/4 (50%) | 0/29 (0%) 1/28 (4%) 2/26 (8%) 6/21 (29%) |
|FIRST INCIDENCE (DAYS) | --- --- 609 539 | --- 681 588 660 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** (e) P=0.028 * P<0.001 ** | P<0.001 ** P=0.131 P=0.109 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** (e) P=0.070 P=0.003 ** | P<0.001 ** P=0.160 P=0.127 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** (e) P=0.041 * P=0.001 ** | P<0.001 ** P=0.126 P=0.121 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | (e) P=0.059 P=0.003 ** | P=0.125 P=0.125 P<0.001 ** |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 3/50 (6%) 6/50 (12%) | 0/49 (0%) 2/50 (4%) 1/50 (2%) 7/50 (14%) |
|ADJUSTED (b) | 0.0% 0.0% 22.0% 66.4% | 0.0% 6.2% 3.8% 29.5% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 2/4 (50%) | 0/29 (0%) 1/28 (4%) 1/26 (4%) 5/21 (24%) |
|FIRST INCIDENCE (DAYS) | --- --- 622 539 | --- 681 733 (T) 660 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** (e) P=0.063 P<0.001 ** | P<0.001 ** P=0.248 P=0.478 P=0.003 ** |
|INCIDENTAL TUMOR | P<0.001 ** (e) P=0.127 P=0.008 ** | P<0.001 ** P=0.272 P=0.478 P=0.005 ** |
|LOGISTIC REGRESSION | P<0.001 ** (e) P=0.077 P=0.005 ** | P<0.001 ** P=0.244 P=0.478 P=0.005 ** |
|COCHRAN-ARMITAGE | P=0.001 ** | P=0.001 ** |
|FISHER EXACT | (e) P=0.121 P=0.013 * | P=0.253 P=0.505 P=0.007 ** |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/49 (0%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 12.5% 0.0% | 0.0% 0.0% 0.0% 4.9% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 721 --- | --- --- --- 591 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.693 (e) P=0.388 (e) | P=0.041 * (e) (e) P=0.234 |
|INCIDENTAL TUMOR | P=0.779N (e) P=0.500 (e) | P=0.096 (e) (e) P=0.328 |
|LOGISTIC REGRESSION | P=0.709 (e) P=0.383 (e) | P=0.041 * (e) (e) P=0.246 |
|COCHRAN-ARMITAGE | P=0.776 | P=0.043 * |
|FISHER EXACT | (e) P=0.500 (e) | (e) (e) P=0.253 |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Carcinoma or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 1/49 (2%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 12.5% 3.3% | 0.0% 0.0% 0.0% 4.9% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 721 608 | --- --- --- 591 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.178 (e) P=0.388 P=0.475 | P=0.041 * (e) (e) P=0.234 |
|INCIDENTAL TUMOR | P=0.297 (e) P=0.500 P=0.500 | P=0.096 (e) (e) P=0.328 |
|LOGISTIC REGRESSION | P=0.227 (e) P=0.383 P=0.515 | P=0.041 * (e) (e) P=0.246 |
|COCHRAN-ARMITAGE | P=0.270 | P=0.043 * |
|FISHER EXACT | (e) P=0.500 P=0.495 | (e) (e) P=0.253 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 6/49 (12%) 4/50 (8%) 6/50 (12%) 10/50 (20%) |
|ADJUSTED (b) | | 19.3% 11.9% 20.5% 31.2% |
|TERMINAL (d) | | 5/29 (17%) 2/28 (7%) 4/26 (15%) 3/21 (14%) |
|FIRST INCIDENCE (DAYS) | | 644 565 608 572 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.029 * P=0.377N P=0.540 P=0.112 |
|INCIDENTAL TUMOR | | P=0.087 P=0.450N P=0.587 P=0.220 |
|LOGISTIC REGRESSION | | P=0.067 P=0.352N P=0.571 P=0.199 |
|COCHRAN-ARMITAGE | | P=0.079 |
|FISHER EXACT | | P=0.357N P=0.606N P=0.220 |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 2/50 (4%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.1% 10.0% 0.0% 5.5% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | 525 730 --- 540 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.250 P=0.729 P=0.531N P=0.469 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.393 P=0.694N P=0.377N P=0.559 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.383 P=0.759N P=0.370N P=0.634 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.345 | (e) |
|FISHER EXACT | P=0.753N P=0.500N P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 27
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 2.2% 0.0% | 0.0% 0.0% 0.0% 7.1% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 506 --- | --- --- --- 648 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.771 (e) P=0.487 (e) | P=0.030 * (e) (e) P=0.200 |
|INCIDENTAL TUMOR | P=0.783N (e) P=0.623 (e) | P=0.064 (e) (e) P=0.312 |
|LOGISTIC REGRESSION | P=0.702N (e) P=0.658 (e) | P=0.042 * (e) (e) P=0.238 |
|COCHRAN-ARMITAGE | P=0.778 | P=0.043 * |
|FISHER EXACT | (e) P=0.500 (e) | (e) (e) P=0.253 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 1/50 (2%) 0/50 (0%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 9.1% 2.2% 0.0% | 0.0% 0.0% 0.0% 7.1% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- 707 506 --- | --- --- --- 648 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.660N P=0.425 P=0.487 (e) | P=0.030 * (e) (e) P=0.200 |
|INCIDENTAL TUMOR | P=0.521N P=0.592 P=0.623 (e) | P=0.064 (e) (e) P=0.312 |
|LOGISTIC REGRESSION | P=0.540N P=0.479 P=0.658 (e) | P=0.042 * (e) (e) P=0.238 |
|COCHRAN-ARMITAGE | P=0.559N | P=0.043 * |
|FISHER EXACT | P=0.500 P=0.500 (e) | (e) (e) P=0.253 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 28
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 6.0% | 0.0% 0.0% 0.0% 3.2% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 530 | --- --- --- 667 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.038 * (e) (e) P=0.217 | P=0.184 (e) (e) P=0.482 |
|INCIDENTAL TUMOR | P=0.048 * (e) (e) P=0.267 | P=0.245 (e) (e) P=0.567 |
|LOGISTIC REGRESSION | P=0.056 (e) (e) P=0.289 | P=0.210 (e) (e) P=0.508 |
|COCHRAN-ARMITAGE | P=0.043 * | P=0.208 |
|FISHER EXACT | (e) (e) P=0.247 | (e) (e) P=0.505 |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 33/50 (66%) 34/50 (68%) 29/50 (58%) 27/50 (54%) | 18/49 (37%) 18/50 (36%) 20/50 (40%) 26/50 (52%) |
|ADJUSTED (b) | 86.3% 90.8% 94.1% 95.6% | 43.4% 43.4% 51.4% 83.0% |
|TERMINAL (d) | 8/13 (62%) 6/9 (67%) 4/5 (80%) 3/4 (75%) | 8/29 (28%) 6/28 (21%) 8/26 (31%) 16/21 (76%) |
|FIRST INCIDENCE (DAYS) | 489 525 506 540 | 366 485 540 525 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.121 P=0.296 P=0.099 P=0.116 | P=0.010 ** P=0.541N P=0.321 P=0.020 * |
|INCIDENTAL TUMOR | P=0.136N P=0.489 P=0.407N P=0.197N | P=0.073 P=0.493 P=0.522 P=0.074 |
|LOGISTIC REGRESSION | P=0.169N P=0.461 P=0.470N P=0.408N | P=0.044 * P=0.536 P=0.504 P=0.088 |
|COCHRAN-ARMITAGE | P=0.082N | P=0.046 * |
|FISHER EXACT | P=0.500 P=0.268N P=0.154N | P=0.553N P=0.449 P=0.092 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 29
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 5/50 (10%) 3/50 (6%) | 1/49 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 4.8% 27.1% 21.1% | 2.3% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/13 (0%) 0/9 (0%) 0/5 (0%) 0/4 (0%) | 0/29 (0%) 0/28 (0%) 0/26 (0%) 0/21 (0%) |
|FIRST INCIDENCE (DAYS) | --- 670 497 609 | 600 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.039 * P=0.500 P=0.014 * P=0.061 | P=0.412N P=0.495N P=0.519N P=0.505N |
|INCIDENTAL TUMOR | P=0.154 P=0.592 P=0.045 * P=0.164 | P=0.320N P=0.638N P=0.436N P=0.419N |
|LOGISTIC REGRESSION | P=0.092 P=0.494 P=0.031 * P=0.089 | P=0.406N P=0.477N P=0.490N P=0.493N |
|COCHRAN-ARMITAGE | P=0.113 | P=0.404N |
|FISHER EXACT | P=0.500 P=0.028 * P=0.121 | P=0.495N P=0.495N P=0.495N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 50/50 (100%) 50/50 (100%) 50/50 (100%) 48/50 (96%) | 44/49 (90%) 48/50 (96%) 49/50 (98%) 46/50 (92%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 95.6% 100.0% 100.0% 95.8% |
|TERMINAL (d) | 13/13 (100%) 9/9 (100%) 5/5 (100%) 4/4 (100%) | 27/29 (93%) 28/28 (100%) 26/26 (100%) 19/21 (90%) |
|FIRST INCIDENCE (DAYS) | 469 357 460 307 | 366 302 450 433 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.013 * P=0.308 P=0.013 * P=0.021 * | P=0.046 * P=0.326 P=0.092 P=0.067 |
|INCIDENTAL TUMOR | P=0.147N (e) (e) P=0.550N | P=0.501 P=0.212 P=0.068 P=0.454 |
|LOGISTIC REGRESSION | P=0.170N (e) (e) P=0.576N | P=0.584 P=0.184 P=0.081 P=0.454 |
|COCHRAN-ARMITAGE | P=0.043N* | P=0.588N |
|FISHER EXACT | P=1.000N P=1.000N P=0.247N | P=0.210 P=0.098 P=0.487 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 30
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 12.8 PPM 32 PPM 80 PPM | CONTROL 12.8 PPM 32 PPM 80 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 40/50 (80%) 37/50 (74%) 37/50 (74%) 36/50 (72%) | 26/49 (53%) 26/50 (52%) 31/50 (62%) 37/50 (74%) |
|ADJUSTED (b) | 95.0% 94.4% 96.5% 96.9% | 60.2% 61.5% 68.2% 89.7% |
|TERMINAL (d) | 11/13 (85%) 7/9 (78%) 4/5 (80%) 3/4 (75%) | 13/29 (45%) 12/28 (43%) 12/26 (46%) 17/21 (81%) |
|FIRST INCIDENCE (DAYS) | 489 525 497 305 | 366 485 470 525 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.026 * P=0.465 P=0.047 * P=0.048 * | P=0.002 ** P=0.539N P=0.168 P=0.008 ** |
|INCIDENTAL TUMOR | P=0.315N P=0.338N P=0.460N P=0.213N | P=0.028 * P=0.505 P=0.362 P=0.034 * |
|LOGISTIC REGRESSION | P=0.496N P=0.370N P=0.547N P=0.434N | P=0.020 * P=0.538N P=0.322 P=0.027 * |
|COCHRAN-ARMITAGE | P=0.262N | P=0.009 ** |
|FISHER EXACT | P=0.318N P=0.318N P=0.241N | P=0.538N P=0.243 P=0.025 * |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 50/50 (100%) 50/50 (100%) 50/50 (100%) 50/50 (100%)| 47/49 (96%) 50/50 (100%) 50/50 (100%) 49/50 (98%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 95.9% 100.0% 100.0% 98.0% |
|TERMINAL (d) | 13/13 (100%) 9/9 (100%) 5/5 (100%) 4/4 (100%) | 27/29 (93%) 28/28 (100%) 26/26 (100%) 20/21 (95%) |
|FIRST INCIDENCE (DAYS) | 469 357 460 305 | 366 302 450 433 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007 ** P=0.308 P=0.013 * P=0.013 * | P=0.044 * P=0.396 P=0.163 P=0.071 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.666 P=0.246 P=0.262 P=0.613 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.666 P=0.246 P=0.262 P=0.613 |
|COCHRAN-ARMITAGE | (e) | P=0.575 |
|FISHER EXACT | P=1.000N P=1.000N P=1.000N | P=0.242 P=0.242 P=0.492 |
|=================================================================================================================================|
DATE: 09/13/96 EXPERIMENT: 05136 TEST: 07 PAGE 31
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).