TDMS Study 05136-07 Pathology Tables
NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 CORE STUDY Facility: Battelle Northwest Chemical CAS #: 0000126-99-8 Lock Date: 05/04/94 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 7| 6| 3| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| DAY ON TEST | 2| 4| 6| 3| 3| 9| 3| 2| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 0| | 1| 4| 6| 5| 4| 7| 5| 2| 4| 1| 4| 1| 5| 5| 4| 4| 4| 4| 5| 4| 3| 3| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 | Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X | Clear Cell Focus | X X X X X X X X X X X | Degeneration, Fatty | 2 3 3 2 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X X| Mixed Cell Focus | X X X | Necrosis | | Bile Duct, Hyperplasia | 2 1 1 1 1 1| Centrilobular, Necrosis | 1 | __________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | | Fat, Necrosis | 2 | __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 2 2 3 2| Basophilic Focus | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 1 | Mineralization | | Ulcer | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | __________________________________________________________________________| Tongue | + | Hyperplasia, Squamous | 4 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 1 2 2 1 1 1 1 1 2 1 2 1 1 2 1 1| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 7| 6| 3| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| DAY ON TEST | 2| 4| 6| 3| 3| 9| 3| 2| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 0| | 1| 4| 6| 5| 4| 7| 5| 2| 4| 1| 4| 1| 5| 5| 4| 4| 4| 4| 5| 4| 3| 3| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Artery, Inflammation, Chronic | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 1 1 2 2 | Hypertrophy | 2 2 1 2 2 1 | Necrosis | 2 | Vacuolization Cytoplasmic | 1 2 2 1 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 2 2 2 2 3| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 2 2 2 1 1 2 1 1 3 1 2 1 2 1 1 1 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M M + + + + + + + + + M + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 3 2 1 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 2 | Inflammation, Granulomatous | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Bronchial | + + M M + + M + + + M + M + M + M + + + M M + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + M M M + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hematopoietic Cell Proliferation | | Hemorrhage | 2 3 3 | __________________________________________________________________________| Thymus | + + M + + + + + + M + + + + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 7| 6| 3| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| DAY ON TEST | 2| 4| 6| 3| 3| 9| 3| 2| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 0| | 1| 4| 6| 5| 4| 7| 5| 2| 4| 1| 4| 1| 5| 5| 4| 4| 4| 4| 5| 4| 3| 3| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Inflammation, Acute | | Inflammation, Chronic Active | 2 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | 4 1 2 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | | Nephropathy | 3 1 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 5| 7| 7| 7| 2| 6| 5| 4| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 0| 3| 5| 8| 3| 3| 3| 2| 6| 8| 3| 3| 6| 8| 3| 3| 6| 3| 7| 3| 3| 3| 5| | | 4| 5| 2| 5| 3| 9| 4| 4| 4| 6| 5| 1| 2| 3| 1| 7| 3| 4| 5| 5| 0| 5| 5| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | 2| 2 2.5| Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Acute | 2 | 1 2.0| Parasite Metazoan | X X | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 1 | 3 1.3| Basophilic Focus | X X X X X X X X X X X X X X X X X X| 39 | Clear Cell Focus | X X X X | 15 | Degeneration, Fatty | 3 | 5 2.6| Eosinophilic Focus | X | 2 | Hepatodiaphragmatic Nodule | X | 4 | Mixed Cell Focus | X X X X| 7 | Necrosis | 2 | 1 2.0| Bile Duct, Hyperplasia | 2 2 1 | 9 1.3| Centrilobular, Necrosis | | 1 1.0| __________________________________________________________________________|____________| Mesentery | + + + + | 5 | Inflammation, Chronic Active | 3 | 1 3.0| Fat, Necrosis | 2 2 2 | 4 2.0| __________________________________________________________________________|____________| Oral Mucosa | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 2 1 2 1 1 2 2 1 1 1 2 1| 18 1.6| Basophilic Focus | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Squamous | | 1 1.0| Mineralization | 2 | 1 2.0| Ulcer | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | | 1 1.0| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 5| 7| 7| 7| 2| 6| 5| 4| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 0| 3| 5| 8| 3| 3| 3| 2| 6| 8| 3| 3| 6| 8| 3| 3| 6| 3| 7| 3| 3| 3| 5| | | 4| 5| 2| 5| 3| 9| 4| 4| 4| 6| 5| 1| 2| 3| 1| 7| 3| 4| 5| 5| 0| 5| 5| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Hyperplasia, Squamous | | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cardiomyopathy | 1 1 2 1 1 1 1 2 1 2 1 2 1 1 2 1 1 2 1 1| 38 1.3| Artery, Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 2 2 2 2 1 2 1 2 2 2 2| 23 1.8| Hypertrophy | 1 1 | 8 1.5| Necrosis | 2 | 2 2.0| Vacuolization Cytoplasmic | 1 2 1 1 | 9 1.4| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 2 1 | 7 1.7| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Hyperplasia | 3 2 2 | 9 2.2| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 2 3 1 1 1 1 1 1 1 2 1 1 1 2 1 2 2 2| 38 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Hyperplasia | 2 1| 2 1.5| Inflammation, Chronic Active | 3 | 4 2.3| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 3 3 3 4 | 7 2.7| Inflammation, Granulomatous | 3 3 | 2 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 3 1 | 3 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 5| 7| 7| 7| 2| 6| 5| 4| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 0| 3| 5| 8| 3| 3| 3| 2| 6| 8| 3| 3| 6| 8| 3| 3| 6| 3| 7| 3| 3| 3| 5| | | 4| 5| 2| 5| 3| 9| 4| 4| 4| 6| 5| 1| 2| 3| 1| 7| 3| 4| 5| 5| 0| 5| 5| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + + + + + + M + + + M + + + M + + + + + M +| 35 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + M + M + + +| 44 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + M| 44 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Fibrosis | 4 2 | 3 2.7| Hematopoietic Cell Proliferation | 4 | 1 4.0| Hemorrhage | 3 | 4 2.8| __________________________________________________________________________|____________| Thymus | + M + + + + M + + + + + + + + + + + + M + + + +| 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Galactocele | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperkeratosis | 3 | 1 3.0| Inflammation, Acute | 1 | 1 1.0| Inflammation, Chronic Active | 2 | 3 2.3| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperostosis | 2 2 | 4 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 1 2 | 6 1.8| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cataract | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 5| 7| 7| 7| 2| 6| 5| 4| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 0| 3| 5| 8| 3| 3| 3| 2| 6| 8| 3| 3| 6| 8| 3| 3| 6| 3| 7| 3| 3| 3| 5| | | 4| 5| 2| 5| 3| 9| 4| 4| 4| 6| 5| 1| 2| 3| 1| 7| 3| 4| 5| 5| 0| 5| 5| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hydronephrosis | 3 | 1 3.0| Nephropathy | 2 2 2 2 1 3 1 2 2 3 2 2 2 1 2 2 2 2 2| 43 1.9| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 5| 6| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 2| 7| 3| 3| 6| 3| 9| 8| 6| 3| 3| 2| 6| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 7| 3| | 5| 1| 4| 5| 5| 3| 4| 1| 7| 0| 4| 1| 5| 5| 4| 5| 4| 2| 4| 4| 5| 7| 3| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 1 2 1 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X X X X X| Degeneration, Fatty | 2 3 | Hepatodiaphragmatic Nodule | X X| Mixed Cell Focus | X | Necrosis | | Bile Duct, Hyperplasia | 1 2 2 1| Centrilobular, Necrosis | 2 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 2 2 2 2 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 2 1 2 1 | Basophilic Focus | | Hyperplasia | 2 | Lipomatosis | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | __________________________________________________________________________| Tongue | + | Hyperplasia, Squamous | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 2 1 1 2 1 2 1 2 2 1 1| Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 5| 6| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 2| 7| 3| 3| 6| 3| 9| 8| 6| 3| 3| 2| 6| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 7| 3| | 5| 1| 4| 5| 5| 3| 4| 1| 7| 0| 4| 1| 5| 5| 4| 5| 4| 2| 4| 4| 5| 7| 3| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Atrophy | | Hyperplasia | 2 2 2 1 2 1 1 2 2 2 | Hypertrophy | 2 3 2 1 2 1 | Vacuolization Cytoplasmic | 1 3 1 1 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hyperplasia | 1 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | C-Cell, Hyperplasia | 1 2 1 1 1 1 2 1 2 1 2 2 2 2 2 3 2 1 2 3| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 4 4 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 2 | Inflammation, Granulomatous | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cervix, Hypertrophy | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Renal, Infiltration Cellular, Plasma | | Cell | | __________________________________________________________________________| Lymph Node, Bronchial | + M + + M + + M M + + + M M + + + + + + + M + M +| __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + M + + + + + + + + + + + + + M M M + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | Fibrosis | 2 | Hematopoietic Cell Proliferation | 2 4 | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 5| 6| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 2| 7| 3| 3| 6| 3| 9| 8| 6| 3| 3| 2| 6| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 7| 3| | 5| 1| 4| 5| 5| 3| 4| 1| 7| 0| 4| 1| 5| 5| 4| 5| 4| 2| 4| 4| 5| 7| 3| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + M + + + + + + + + + + M + + + + + + M + M + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 3 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 3 4| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion, Chronic | | Hemorrhage | 1 | Inflammation, Chronic Active | 2 | Alveolar Epithelium, Hyperplasia | 2 1 2 1 1 1 2 1 3 2 1 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | Thrombosis | | Olfactory Epithelium, Atrophy | | Olfactory Epithelium, Metaplasia | | Turbinate, Fibrosis, Focal | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Degeneration | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Nephropathy | 3 2 2 3 2 2 2 2 1 2 3 1 2 3 2 2 2 3 2 2 2 1 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 9| 8| 5| 2| 3| 0| 3| 3| 3| 2| 8| 0| 3| 3| | | 4| 5| 4| 5| 5| 2| 9| 4| 4| 4| 3| 1| 1| 7| 1| 3| 7| 3| 3| 5| 6| 5| 8| 4| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | Inflammation, Acute | 1 | 1 1.0| Parasite Metazoan | X X X | 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | Inflammation, Acute | 3 | 1 3.0| Parasite Metazoan | X X X | 4 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 1 | 7 1.4| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 43 | Clear Cell Focus | X X X X X X X X| 16 | Degeneration, Fatty | 2 3 3 | 5 2.6| Hepatodiaphragmatic Nodule | X X X X X | 7 | Mixed Cell Focus | X X X X X| 6 | Necrosis | 1 | 1 1.0| Bile Duct, Hyperplasia | 2 1 2 2 2 2 | 10 1.7| Centrilobular, Necrosis | 1 2 | 3 1.7| __________________________________________________________________________|____________| Mesentery | + + | 6 | Fat, Necrosis | 2 2 | 6 2.0| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 3 2 1 4 2 2| 14 1.7| Basophilic Focus | X | 1 | Hyperplasia | 2 | 2 2.0| Lipomatosis | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 2 | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 | 1 1.0| __________________________________________________________________________|____________| Tongue | + + + | 4 | Hyperplasia, Squamous | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 9| 8| 5| 2| 3| 0| 3| 3| 3| 2| 8| 0| 3| 3| | | 4| 5| 4| 5| 5| 2| 9| 4| 4| 4| 3| 1| 1| 7| 1| 3| 7| 3| 3| 5| 6| 5| 8| 4| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Cardiomyopathy | 1 1 3 2 2 1 1 1 1 1 1 1 1 2 1 1 1 2| 38 1.3| Atrium, Thrombosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 1 2.0| Hyperplasia | 1 2 1 2 2 2 1 1 2 2 2 2| 22 1.7| Hypertrophy | 1 1 2 2 | 10 1.7| Vacuolization Cytoplasmic | | 5 1.6| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 3 | 11 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2| 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 4 | 1 4.0| Hyperplasia | 2 | 2 1.5| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 3 3 2 2 | 5 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 1 2.0| C-Cell, Hyperplasia | 3 2 1 1 2 1 1 1 1 1 1 3 2 1 1 1 1 1| 38 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 | Hyperplasia | 4 | 1 4.0| Inflammation, Chronic Active | 2 | 4 3.3| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 4 3 | 6 2.5| Inflammation, Granulomatous | 2 | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cervix, Hypertrophy | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + | 4 | Renal, Infiltration Cellular, Plasma | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 9| 8| 5| 2| 3| 0| 3| 3| 3| 2| 8| 0| 3| 3| | | 4| 5| 4| 5| 5| 2| 9| 4| 4| 4| 3| 1| 1| 7| 1| 3| 7| 3| 3| 5| 6| 5| 8| 4| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Cell | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + M + + M + + + + + + M M M + + M + + M +| 34 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 | Hemorrhage | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + + + + + + + + M + + + M + + + + + + +| 43 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Spleen | | 1 | Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | 2 2 | 4 2.5| __________________________________________________________________________|____________| Thymus | + + + + + + + M + + M + + + + + + M + M + + + + +| 41 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Galactocele | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 4 | 5 2.6| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 3 4 | 5 3.2| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion, Chronic | 3 | 1 3.0| Hemorrhage | | 1 1.0| Inflammation, Chronic Active | | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 1 1 1 1 1 1 1 2 1| 22 1.4| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 3 | 2 2.5| Thrombosis | 2 | 1 2.0| Olfactory Epithelium, Atrophy | 1 | 1 1.0| Olfactory Epithelium, Metaplasia | 1 | 1 1.0| Turbinate, Fibrosis, Focal | | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 9| 8| 5| 2| 3| 0| 3| 3| 3| 2| 8| 0| 3| 3| | | 4| 5| 4| 5| 5| 2| 9| 4| 4| 4| 3| 1| 1| 7| 1| 3| 7| 3| 3| 5| 6| 5| 8| 4| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Degeneration | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 3 | 1 3.0| Nephropathy | 2 2 2 1 2 2 2 2 2 2 4 2 1 1 2 1 1 2 2 3 3 1 2 2 2| 48 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 5| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 6| 5| 7| 7| 7| 7| 6| 6| 6| 4| DAY ON TEST | 3| 3| 9| 3| 8| 3| 6| 4| 9| 9| 3| 7| 3| 8| 2| 1| 9| 3| 3| 3| 3| 5| 0| 9| 5| | 3| 4| 7| 5| 5| 5| 7| 6| 3| 1| 4| 0| 5| 8| 1| 8| 7| 3| 4| 4| 5| 1| 1| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| Parasite Metazoan | X| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 1 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X X | Degeneration, Fatty | 2 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X X | Mixed Cell Focus | X X X X | Bile Duct, Hyperplasia | 1 2 1 1 2 2 1 2 | Centrilobular, Necrosis | 2 1 2 1 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 2 2 3 2 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 3 2 2 1 1 1 2 2 1| Basophilic Focus | | Hyperplasia | | Lipomatosis | 3 | Metaplasia, Hepatocyte | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Basophilic Focus | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 1 | Necrosis | 1 3 1 | Ulcer | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Necrosis | 2 | __________________________________________________________________________| Tongue | + + + | Hyperplasia, Squamous | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 5| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 6| 5| 7| 7| 7| 7| 6| 6| 6| 4| DAY ON TEST | 3| 3| 9| 3| 8| 3| 6| 4| 9| 9| 3| 7| 3| 8| 2| 1| 9| 3| 3| 3| 3| 5| 0| 9| 5| | 3| 4| 7| 5| 5| 5| 7| 6| 3| 1| 4| 0| 5| 8| 1| 8| 7| 3| 4| 4| 5| 1| 1| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 1 1 1 2 2 1 1 2 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 1 2 2 1 | Hypertrophy | 2 2 3 | Necrosis | 2 | Vacuolization Cytoplasmic | 2 1 2 1 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 1 2 1 2 1 1 1 1 2 1 1 2 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| Hyperplasia | 1 2 2 | Inflammation, Chronic Active | 2 2 2 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Granulomatous | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Histiocytic | 2 | __________________________________________________________________________| Lymph Node | + + | Iliac, Ectasia | 3 | __________________________________________________________________________| Lymph Node, Bronchial | + + M M M + + + M + M + + + M + + + + + + M + + M| __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + M + + + M M + + + + + M + M + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + M M M + + + + + + + + + M M + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 3 2 | Hematopoietic Cell Proliferation | 2 3 | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 5| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 6| 5| 7| 7| 7| 7| 6| 6| 6| 4| DAY ON TEST | 3| 3| 9| 3| 8| 3| 6| 4| 9| 9| 3| 7| 3| 8| 2| 1| 9| 3| 3| 3| 3| 5| 0| 9| 5| | 3| 4| 7| 5| 5| 5| 7| 6| 3| 1| 4| 0| 5| 8| 1| 8| 7| 3| 4| 4| 5| 1| 1| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 3 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 4 4 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | 1 1 3 1 1 1 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Thrombosis | 2 | Olfactory Epithelium, Atrophy | 1 2 1 3 1 1 1 1 3 1 1 2 1 2 2 1 1 2| Olfactory Epithelium, Hyperplasia, | | Basal Cell | 1 1 2 1 1 1 1 1 | Olfactory Epithelium, Inflammation, | | Chronic Active | 1 1 | Olfactory Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Olfactory Epithelium, Necrosis | 2 3 1 3 3 2 | Turbinate, Fibrosis, Focal | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 2 | Retina, Atrophy | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 2 2 2 1 3 1 2 2 2 2 1 2 1 2 1 1 2 3 3 2 3 1 2| Renal Tubule, Hyperplasia | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 5| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 4| 4| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 9| 3| 0| 0| 3| 3| 3| | | 4| 0| 4| 5| 4| 1| 5| 4| 3| 5| 3| 5| 9| 4| 4| 5| 4| 4| 0| 5| 8| 4| 4| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X | 6 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X | 7 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X X| 8 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 1 | 5 1.8| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X| 45 | Clear Cell Focus | X X X X X X X X X| 14 | Degeneration, Fatty | 2 2 | 3 2.0| Eosinophilic Focus | | 1 | Hepatodiaphragmatic Nodule | X X X X X X | 9 | Mixed Cell Focus | X X | 6 | Bile Duct, Hyperplasia | 2 1 1 | 11 1.5| Centrilobular, Necrosis | 1 | 5 1.4| __________________________________________________________________________|____________| Mesentery | + + + + | 8 | Fat, Necrosis | 2 1 2 | 7 2.0| __________________________________________________________________________|____________| Oral Mucosa | + | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 2 4 1 1 2 2 | 17 1.8| Basophilic Focus | X | 1 | Hyperplasia | 3 | 1 3.0| Lipomatosis | 4 | 2 3.5| Metaplasia, Hepatocyte | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 1 2.0| Basophilic Focus | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | | 1 1.0| Necrosis | | 3 1.7| Ulcer | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 1 1 1 | 4 1.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 5| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 4| 4| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 9| 3| 0| 0| 3| 3| 3| | | 4| 0| 4| 5| 4| 1| 5| 4| 3| 5| 3| 5| 9| 4| 4| 5| 4| 4| 0| 5| 8| 4| 4| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Necrosis | | 1 2.0| __________________________________________________________________________|____________| Tongue | + + | 5 | Hyperplasia, Squamous | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 2 1 2 2 2 1 1 2 2 2 1 1 1 1 2| 31 1.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 2 2 1 1 2 1 1 2 2 2 2 2 | 22 1.7| Hypertrophy | 2 1 2 2 | 7 2.0| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | 2 2 1 2 | 10 1.7| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 1 2 | 7 1.7| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 3 | 3 2.3| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 3| 3 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 1 1 1 2 1 1 2 1 1 2 2 1 2 2 1 2 1| 35 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + M M + + + + M + + + + + + + + + + + + + + + +| 46 | Hyperplasia | 3 | 4 2.0| Inflammation, Chronic Active | 3 1 | 6 2.2| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 1 2.0| Inflammation, Granulomatous | | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 5| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 4| 4| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 9| 3| 0| 0| 3| 3| 3| | | 4| 0| 4| 5| 4| 1| 5| 4| 3| 5| 3| 5| 9| 4| 4| 5| 4| 4| 0| 5| 8| 4| 4| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia, Histiocytic | 4 | 2 3.0| __________________________________________________________________________|____________| Lymph Node | + + | 4 | Iliac, Ectasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M M + M + M + + + + + M + M M + + + M M + M M M +| 30 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + M M M + + + + + + M + + + + + + + M + M| 37 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + + M + + + + + + + + +| 43 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | | 3 2.3| Hematopoietic Cell Proliferation | 2 3 | 4 2.5| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + M + M +| 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Galactocele | | 2 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 2 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 4 | 4 3.5| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 1 3 2 1 2 2 1 3 1 1 1 1 2 1 | 22 1.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Thrombosis | | 1 2.0| Olfactory Epithelium, Atrophy | 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.3| Olfactory Epithelium, Hyperplasia, | | | Basal Cell | 1 1 1 1 1 1 1 1 1 | 17 1.1| Olfactory Epithelium, Inflammation, | | | Chronic Active | | 2 1.0| Olfactory Epithelium, Metaplasia | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 5| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 4| 4| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 9| 3| 0| 0| 3| 3| 3| | | 4| 0| 4| 5| 4| 1| 5| 4| 3| 5| 3| 5| 9| 4| 4| 5| 4| 4| 0| 5| 8| 4| 4| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Olfactory Epithelium, Necrosis | 1 1 | 8 2.0| Turbinate, Fibrosis, Focal | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 3 | Cataract | 2 | 2 2.0| Retina, Atrophy | 3 | 2 3.5| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy | 1 1 1 2 2 1 3 3 2 3 3 3 2 3 2 2 3 3 2 1 2 1 3 1 1| 49 2.0| Renal Tubule, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 6| 5| 7| 4| 7| 7| 6| 7| 7| 6| 6| DAY ON TEST | 3| 3| 3| 3| 7| 3| 8| 2| 3| 2| 2| 3| 3| 4| 7| 5| 3| 6| 2| 3| 0| 3| 3| 1| 4| | 7| 4| 5| 4| 2| 5| 9| 4| 4| 0| 4| 5| 4| 9| 3| 3| 4| 3| 1| 3| 9| 4| 4| 1| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 1 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X | Clear Cell Focus | X X X X | Degeneration, Cystic | | Degeneration, Fatty | 2 2 | Eosinophilic Focus | X X | Hepatodiaphragmatic Nodule | X X X X X X | Mixed Cell Focus | X X X X X X | Necrosis | | Bile Duct, Hyperplasia | 1 2 2 2 2 1 1 2 | Centrilobular, Necrosis | 1 1 1 1 | __________________________________________________________________________| Mesentery | + + + + + + + | Inflammation, Chronic Active | | Fat, Necrosis | 2 2 2 2 2 3 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 2 2 | Basophilic Focus | | Hyperplasia | | Artery, Inflammation | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 4 | Mineralization | 1 | Necrosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 1 | __________________________________________________________________________| Tongue | + + + + + | Hyperplasia, Squamous | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 6| 5| 7| 4| 7| 7| 6| 7| 7| 6| 6| DAY ON TEST | 3| 3| 3| 3| 7| 3| 8| 2| 3| 2| 2| 3| 3| 4| 7| 5| 3| 6| 2| 3| 0| 3| 3| 1| 4| | 7| 4| 5| 4| 2| 5| 9| 4| 4| 0| 4| 5| 4| 9| 3| 3| 4| 3| 1| 3| 9| 4| 4| 1| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 2 1 1 1 1 2 1 2 1 2 1 1 2 2 2 1| Artery, Inflammation, Chronic | | Schwann Cell, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 1 3 2 1 3 | Hypertrophy | 3 2 1 1 | Vacuolization Cytoplasmic | 2 2 2 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 3 2 1 3 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 1 2 1 1 2 1 1 2 2 1 2 1 1 1 1 3| Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + M + + + + M + + + + + + + +| Hyperplasia | 1 3 2 | Inflammation, Chronic Active | 2 2 2| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | __________________________________________________________________________| Lymph Node | + + | Iliac, Ectasia | 2 | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + M + M + + M + + + M + + + + + + M + + M| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 6| 5| 7| 4| 7| 7| 6| 7| 7| 6| 6| DAY ON TEST | 3| 3| 3| 3| 7| 3| 8| 2| 3| 2| 2| 3| 3| 4| 7| 5| 3| 6| 2| 3| 0| 3| 3| 1| 4| | 7| 4| 5| 4| 2| 5| 9| 4| 4| 0| 4| 5| 4| 9| 3| 3| 4| 3| 1| 3| 9| 4| 4| 1| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Angiectasis | 2 | Fibrosis | 3 2 1 | Hematopoietic Cell Proliferation | 4 4 3| __________________________________________________________________________| Thymus | + + M + + + + + + + + + + + M + + + M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Inflammation, Chronic Active | 1 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fracture | X | Hyperostosis | 2 | Hyperplasia | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Alveolar Epithelium, Hyperplasia | 2 1 1 2 2 1 1 1 1 1 2 1 2 | Artery, Mediastinum, Inflammation | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Thrombosis | 1 | Nasolacrimal Duct, Hyperplasia, | | Squamous | | Olfactory Epithelium, Atrophy | 2 4 4 4 3 3 3 3 3 4 3 3 3 4 3 2 4 2 3 3 2 3 3 3 3| Olfactory Epithelium, Fibrosis | 2 2 2 1 2 3 3 3 4 2 2 3 3 2 2 1 3 2 3 2 3 2 1 2| Olfactory Epithelium, Hyperplasia, | | Basal Cell | 2 2 2 2 1 3 3 3 3 2 3 3 3 2 2 2 3 1 3 3 3 3 1 1 2| Olfactory Epithelium, Hyperplasia, | | Adenomatous | 2 2 3 2 3 2 3 1 1 1 2 1 1 2 3| Olfactory Epithelium, Inflammation, | | Chronic Active | 2 2 2 2 1 2 2 2 2 1 1 4 2 2| Olfactory Epithelium, Metaplasia | 2 3 3 4 3 3 3 2 3 3 3 3 3 3 3 2 4 2 2 3 2 3 3 3 3| Olfactory Epithelium, Necrosis | 1 2 1 1 1 2 | Olfactory Epithelium, Glands, Atypia | | Cellular | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 6| 5| 7| 4| 7| 7| 6| 7| 7| 6| 6| DAY ON TEST | 3| 3| 3| 3| 7| 3| 8| 2| 3| 2| 2| 3| 3| 4| 7| 5| 3| 6| 2| 3| 0| 3| 3| 1| 4| | 7| 4| 5| 4| 2| 5| 9| 4| 4| 0| 4| 5| 4| 9| 3| 3| 4| 3| 1| 3| 9| 4| 4| 1| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 3 | Retina, Atrophy | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Oncocytic | 2 | Infarct | 3 | Mineralization | | Nephropathy | 2 3 2 3 2 1 2 3 2 2 2 2 1 3 2 2 2 3 2 2 2 1 2 3| Artery, Inflammation | | Pelvis, Inflammation, Acute | | Renal Tubule, Hyperplasia | 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 5| 7| 7| 6| 4| 7| 5| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 2| 2| 0| 3| 7| 9| 3| 3| 1| 3| 3| 7| 3| 6| 3| 3| 3| 6| 1| 1| 6| 0| 3| 3| 7| | | 5| 9| 5| 4| 1| 1| 3| 4| 7| 3| 5| 6| 5| 7| 3| 4| 5| 6| 3| 6| 0| 5| 4| 4| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 3.0| Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Parasite Metazoan | X X X | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 3 2 3 2 | 8 1.9| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 44 | Clear Cell Focus | X X | 6 | Degeneration, Cystic | 1 1 | 2 1.0| Degeneration, Fatty | 3| 3 2.3| Eosinophilic Focus | | 2 | Hepatodiaphragmatic Nodule | X X X | 9 | Mixed Cell Focus | X X X | 9 | Necrosis | 2 3 | 2 2.5| Bile Duct, Hyperplasia | 2 1 2 1 1 2 2 2 | 16 1.6| Centrilobular, Necrosis | 1 2 1 1 | 8 1.1| __________________________________________________________________________|____________| Mesentery | + + + + | 11 | Inflammation, Chronic Active | 4 | 1 4.0| Fat, Necrosis | 2 2 2 | 9 2.1| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 2 1 3 | 9 1.6| Basophilic Focus | X X X | 3 | Hyperplasia | 1 2 | 2 1.5| Artery, Inflammation | 4 | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 2 | 3 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | 2 3 | 3 3.0| Mineralization | | 1 1.0| Necrosis | 2| 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 5| 7| 7| 6| 4| 7| 5| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 2| 2| 0| 3| 7| 9| 3| 3| 1| 3| 3| 7| 3| 6| 3| 3| 3| 6| 1| 1| 6| 0| 3| 3| 7| | | 5| 9| 5| 4| 1| 1| 3| 4| 7| 3| 5| 6| 5| 7| 3| 4| 5| 6| 3| 6| 0| 5| 4| 4| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 | 3 2.0| __________________________________________________________________________|____________| Tongue | + + + + + + + | 12 | Hyperplasia, Squamous | | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 2 2 1 2 2 2 1 2 2 1 2 2 1 2 2 2 2 1 1| 41 1.5| Artery, Inflammation, Chronic | 3 | 1 3.0| Schwann Cell, Hyperplasia | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 1 2 1 2 2 2 1 2| 20 1.8| Hypertrophy | 2 1 2 1 2 2 | 10 1.7| Vacuolization Cytoplasmic | 2 2 2 1 | 8 1.8| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 1 3 2 | 10 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + M +| 48 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 3 2 2 2 2 | 10 2.2| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 1 1 1 3 1 2 1 1 2| 28 1.5| Follicular Cell, Hyperplasia | 3 | 2 2.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + M + + + + + + + + + + + + + + M + + + + +| 46 | Hyperplasia | 3 | 4 2.3| Inflammation, Chronic Active | 2 | 4 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 3 | 3 2.3| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 5| 7| 7| 6| 4| 7| 5| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 2| 2| 0| 3| 7| 9| 3| 3| 1| 3| 3| 7| 3| 6| 3| 3| 3| 6| 1| 1| 6| 0| 3| 3| 7| | | 5| 9| 5| 4| 1| 1| 3| 4| 7| 3| 5| 6| 5| 7| 3| 4| 5| 6| 3| 6| 0| 5| 4| 4| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + | 5 | Iliac, Ectasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + M + M + + + + + M + + + + + + M M + M M +| 36 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + + + + + + + + + M + + + + M + + + + +| 45 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Spleen | | 1 | Angiectasis | | 1 2.0| Fibrosis | 2 3 | 5 2.2| Hematopoietic Cell Proliferation | 2 2 4 | 6 3.2| __________________________________________________________________________|____________| Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | | 1 | Inflammation, Chronic Active | 2 | 3 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fracture | | 1 | Hyperostosis | 2 2 | 3 2.0| Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 2 2.0| Alveolar Epithelium, Hyperplasia | 2 1 1 3 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1| 34 1.3| Artery, Mediastinum, Inflammation | 3 | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Thrombosis | 2 2 | 3 1.7| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 5| 7| 7| 6| 4| 7| 5| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 2| 2| 0| 3| 7| 9| 3| 3| 1| 3| 3| 7| 3| 6| 3| 3| 3| 6| 1| 1| 6| 0| 3| 3| 7| | | 5| 9| 5| 4| 1| 1| 3| 4| 7| 3| 5| 6| 5| 7| 3| 4| 5| 6| 3| 6| 0| 5| 4| 4| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Nasolacrimal Duct, Hyperplasia, | | | Squamous | 3 | 1 3.0| Olfactory Epithelium, Atrophy | 2 3 2 3 3 3 2 2 3 2 3 3 3 3 3 2 3 3 3 3 3 4 3 3 3| 50 2.9| Olfactory Epithelium, Fibrosis | 2 2 2 2 3 2 2 3 1 1 2 2 2 1 2 2 2 1 2 3 3 3 2 2 2| 49 2.2| Olfactory Epithelium, Hyperplasia, | | | Basal Cell | 2 2 2 3 3 3 2 3 3 2 3 2 2 2 2 3 1 2 3 3 3 2 2 2| 49 2.3| Olfactory Epithelium, Hyperplasia, | | | Adenomatous | 2 3 2 2 3 1 1 3 3 2 2 1| 27 2.0| Olfactory Epithelium, Inflammation, | | | Chronic Active | 1 2 1 2 2 2 1 3 2 3 1 1 4 2 2 2 3 3 3| 33 2.0| Olfactory Epithelium, Metaplasia | 2 3 2 3 2 3 2 2 3 2 2 2 3 3 3 2 2 3 3 3 3 4 3 3 3| 50 2.7| Olfactory Epithelium, Necrosis | 1 1 1 1 2 2| 12 1.3| Olfactory Epithelium, Glands, Atypia | | | Cellular | 4 | 2 2.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | Cataract | 3 | 2 3.0| Retina, Atrophy | 4 | 2 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Oncocytic | | 1 2.0| Infarct | | 1 3.0| Mineralization | 2 | 1 2.0| Nephropathy | 1 2 2 3 1 3 1 3 3 1 3 1 2 3 3 3 3 2 2 2 1 3 3 2 2| 49 2.2| Artery, Inflammation | 3 | 1 3.0| Pelvis, Inflammation, Acute | 3 | 1 3.0| Renal Tubule, Hyperplasia | 1 3 | 4 1.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 5| 5| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 6| 5| 7| 7| 6| 5| 7| 7| 4| 6| 7| DAY ON TEST | 7| 3| 0| 2| 5| 1| 3| 1| 0| 3| 7| 3| 9| 9| 1| 8| 3| 3| 3| 3| 3| 0| 8| 1| 3| | 5| 4| 4| 2| 7| 6| 7| 6| 0| 3| 6| 7| 3| 5| 3| 9| 3| 3| 4| 6| 3| 2| 9| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 4 | Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X | Clear Cell Focus | X X X X X | Degeneration, Cystic | 4 3 2 2 2 | Degeneration, Fatty | 2 2 | Hepatodiaphragmatic Nodule | X | Regeneration | 4 | Bile Duct, Hyperplasia | 3 3 3 3 1 2 3 1 2 2 2 2 3 3 2 1| Centrilobular, Necrosis | 2 2 1 2 2 | __________________________________________________________________________| Mesentery | + + + + + + + | Inflammation, Chronic Active | | Fat, Hemorrhage | | Fat, Necrosis | 2 2 2 3 2 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 2 2 1 1 1 2 1 2 1 2 2 3 2| Basophilic Focus | X | Hyperplasia | 3 2 1 2 1| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 2 | Mineralization | | Necrosis | 1 1 | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 1 | Necrosis | 1 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 1 2 2 2 2 2 3 2 2 2 2 2 2 2 1 1 2 2 1 2 3| Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 5| 5| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 6| 5| 7| 7| 6| 5| 7| 7| 4| 6| 7| DAY ON TEST | 7| 3| 0| 2| 5| 1| 3| 1| 0| 3| 7| 3| 9| 9| 1| 8| 3| 3| 3| 3| 3| 0| 8| 1| 3| | 5| 4| 4| 2| 7| 6| 7| 6| 0| 3| 6| 7| 3| 5| 3| 9| 3| 3| 4| 6| 3| 2| 9| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 1 2 2 2 2 1 1 2 2| Hypertrophy | 3 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 1 1 2 2 1 2 3 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + M + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 2 2 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 2 1 2 1 2 1 1 2 1 2 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + | Hyperplasia | 3 | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2| __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 | Inflammation, Chronic Active | 3 1 2 2 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 2 | Inflammation, Chronic Active | 2 | Mineralization | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Artery, Inflammation, Chronic Active | 2 2 | Interstitial Cell, Hyperplasia | 2 1 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | __________________________________________________________________________| Lymph Node | + + + + + | Renal, Hemorrhage | | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 5| 5| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 6| 5| 7| 7| 6| 5| 7| 7| 4| 6| 7| DAY ON TEST | 7| 3| 0| 2| 5| 1| 3| 1| 0| 3| 7| 3| 9| 9| 1| 8| 3| 3| 3| 3| 3| 0| 8| 1| 3| | 5| 4| 4| 2| 7| 6| 7| 6| 0| 3| 6| 7| 3| 5| 3| 9| 3| 3| 4| 6| 3| 2| 9| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + + + + + M + + + + + + + + + + M + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M M +| Ectasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | Fibrosis | 2 2 2 3 3 3 2 2 2 | Hematopoietic Cell Proliferation | | Hemorrhage | | Necrosis | | __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + M + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M + M + M M M + + + M + + M M M + + + + + +| Galactocele | 2 2 | Inflammation, Chronic | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Infiltration Cellular | 3 | Metaplasia, Cartilagenous | 2 | Thrombosis | | Alveolar Epithelium, Hyperplasia | 1 2 2 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 3 | Thrombosis | 3 1 1 3 4 | Olfactory Epithelium, Atrophy | 2 | Olfactory Epithelium, Hyperplasia, | | Adenomatous | 2 2 | Olfactory Epithelium, Metaplasia | 2 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 5| 5| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 6| 5| 7| 7| 6| 5| 7| 7| 4| 6| 7| DAY ON TEST | 7| 3| 0| 2| 5| 1| 3| 1| 0| 3| 7| 3| 9| 9| 1| 8| 3| 3| 3| 3| 3| 0| 8| 1| 3| | 5| 4| 4| 2| 7| 6| 7| 6| 0| 3| 6| 7| 3| 5| 3| 9| 3| 3| 4| 6| 3| 2| 9| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Mineralization | 2 | Nephropathy | 2 3 3 2 3 3 2 3 2 4 1 3 3 3 4 2 3 3 3 3 4 3 2 4 3| Renal Tubule, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular | 2 | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 5| 4| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 1| 3| 8| 3| 3| 7| 3| 9| 3| 4| 6| 9| 3| 5| 3| 2| 6| 6| 4| 1| 4| 4| | | 3| 3| 3| 6| 3| 0| 3| 4| 1| 3| 5| 3| 1| 9| 5| 3| 8| 3| 5| 9| 9| 6| 6| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 | 1 2.0| Parasite Metazoan | X X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + A +| 48 | Necrosis | | 1 4.0| Parasite Metazoan | X X X X X X X | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + A +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 1 | 2 1.5| Basophilic Focus | X X X X X X | 16 | Clear Cell Focus | X X X | 8 | Degeneration, Cystic | 2 4 2 3 2 2 2 2 | 13 2.5| Degeneration, Fatty | 3| 3 2.3| Hepatodiaphragmatic Nodule | X | 2 | Regeneration | 4 | 2 4.0| Bile Duct, Hyperplasia | 2 3 3 2 3 2 2 2 1 2 3 1 2 2 1 3 3 3 2 2| 36 2.2| Centrilobular, Necrosis | 1 2 1 2 1 2 2 2 | 13 1.7| __________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 16 | Inflammation, Chronic Active | 4 | 1 4.0| Fat, Hemorrhage | 4 | 1 4.0| Fat, Necrosis | 3 2 2 2 2 2 2 2 | 15 2.1| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 3 1 2 1 2 3 1 1 3 2 | 27 1.7| Basophilic Focus | X | 2 | Hyperplasia | 3 3| 7 2.1| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | 2 | 2 2.0| Mineralization | 1 | 1 1.0| Necrosis | | 2 1.0| Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 | Mineralization | 1 2 1| 5 1.2| Necrosis | | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 5| 4| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 1| 3| 8| 3| 3| 7| 3| 9| 3| 4| 6| 9| 3| 5| 3| 2| 6| 6| 4| 1| 4| 4| | | 3| 3| 3| 6| 3| 0| 3| 4| 1| 3| 5| 3| 1| 9| 5| 3| 8| 3| 5| 9| 9| 6| 6| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 2 1 2 2 2 1 1 2 1 2 1 3 1 1 1 2 2 2| 43 1.8| Atrium, Thrombosis | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 1 2 2 2 1 2 2| 23 1.8| Hypertrophy | | 1 3.0| Vacuolization Cytoplasmic | 3 | 1 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 3 1 2 2 1 | 23 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 3 | 3 2.7| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 2 1 1 3 | 5 1.8| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 2 2 3 | 7 2.1| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 1 3 2 1 1 1 1 1 1 1 1 1 1 2| 34 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | | 1 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 3 | 2 2.5| __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 4 1.8| Inflammation, Chronic Active | 3 2 1 3 | 9 2.2| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 2 2 | 7 1.9| Inflammation, Chronic Active | 3 | 2 2.5| Mineralization | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 5| 4| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 1| 3| 8| 3| 3| 7| 3| 9| 3| 4| 6| 9| 3| 5| 3| 2| 6| 6| 4| 1| 4| 4| | | 3| 3| 3| 6| 3| 0| 3| 4| 1| 3| 5| 3| 1| 9| 5| 3| 8| 3| 5| 9| 9| 6| 6| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 1 2.0| Artery, Inflammation, Chronic Active | | 2 2.0| Interstitial Cell, Hyperplasia | 1 1 2 1 1 1| 10 1.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + | 12 | Renal, Hemorrhage | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + + + M + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 | Ectasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + M + + + + + + +| 46 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Spleen | X | 2 | Fibrosis | 3 2 3 3 2 3 3 2| 17 2.5| Hematopoietic Cell Proliferation | 2 2 | 2 2.0| Hemorrhage | 3 | 1 3.0| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Thymus | + M + + M + + + + + + + M + + + + + M M + + + + +| 42 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + + + + + M M M + M + + + M + + M M M M + M +| 30 | Galactocele | 2 2| 4 2.0| Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 1 | Inflammation, Chronic Active | 2 3 2 | 3 2.3| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 5| 4| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 1| 3| 8| 3| 3| 7| 3| 9| 3| 4| 6| 9| 3| 5| 3| 2| 6| 6| 4| 1| 4| 4| | | 3| 3| 3| 6| 3| 0| 3| 4| 1| 3| 5| 3| 1| 9| 5| 3| 8| 3| 5| 9| 9| 6| 6| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Acute | 2| 1 2.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 | 1 1.0| Infiltration Cellular | | 1 3.0| Metaplasia, Cartilagenous | | 1 2.0| Thrombosis | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 1 | 5 1.4| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 3.0| Thrombosis | 2 4 2 3 2 | 10 2.5| Olfactory Epithelium, Atrophy | 1 2 | 3 1.7| Olfactory Epithelium, Hyperplasia, | | | Adenomatous | | 2 2.0| Olfactory Epithelium, Metaplasia | 2 1 2 | 6 1.7| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 2 2 | 3 2.0| Mineralization | | 1 2.0| Nephropathy | 3 2 4 2 4 2 4 3 2 2 3 3 2 2 4 3 3 4 2 2 3 2 3 2 3| 50 2.8| Renal Tubule, Hyperplasia | 2 3 | 2 2.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 5| 6| 7| 4| 6| 7| DAY ON TEST | 3| 3| 0| 3| 3| 8| 3| 1| 6| 0| 1| 3| 6| 0| 4| 0| 7| 3| 7| 2| 4| 3| 9| 6| 3| | 8| 3| 0| 4| 3| 9| 3| 3| 5| 2| 8| 0| 3| 1| 4| 1| 0| 3| 7| 5| 5| 3| 7| 5| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X | __________________________________________________________________________| Intestine Large, Rectum | + + I + + A + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 2 1 | Basophilic Focus | X X X X X X X X X | Clear Cell Focus | X X X X | Degeneration, Cystic | 2 3 2 2 2 4 3 2 2 1 1 | Degeneration, Fatty | 2 | Hepatodiaphragmatic Nodule | X | Inflammation, Chronic | 1 | Mixed Cell Focus | X | Necrosis | 1 | Regeneration | 3 | Bile Duct, Hyperplasia | 3 3 3 1 1 3 3 3 1 2 2 1 3 2 2 1 1 3 1 1 2| Centrilobular, Necrosis | 2 2 2 3 1 1 | __________________________________________________________________________| Mesentery | + + + + + + | Inflammation, Chronic Active | | Fat, Necrosis | 2 2 2 2 3 2 | __________________________________________________________________________| Oral Mucosa | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 1 2 2 2 3 3 2 1 2 2 1| Basophilic Focus | X | Hyperplasia | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Mineralization | 2 | Necrosis | 4 4 2 3 | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 2 2 | Necrosis | 3 3 | __________________________________________________________________________| Tooth | + | Developmental Malformation | X | Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 5| 6| 7| 4| 6| 7| DAY ON TEST | 3| 3| 0| 3| 3| 8| 3| 1| 6| 0| 1| 3| 6| 0| 4| 0| 7| 3| 7| 2| 4| 3| 9| 6| 3| | 8| 3| 0| 4| 3| 9| 3| 3| 5| 2| 8| 0| 3| 1| 4| 1| 0| 3| 7| 5| 5| 3| 7| 5| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 3 2 2 2 3 2 2 2 3 2 1 1 2 2 2 2 2 3 2 3 3| Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 2 2 1 2 2 1 2 2 1 2 2 2| Hypertrophy | | Necrosis | 3 | Vacuolization Cytoplasmic | 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2 2 2 1 2 2 2 3 3 2| Necrosis | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 4 1 2| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Pars Distalis, Cyst | 3 | Pars Distalis, Hyperplasia | 2 | Pars Intermedia, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 1 1 2 1 3 2 1 1 1 2 2 1| Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | Hyperplasia | 3 3 | __________________________________________________________________________| Penis | + | Vein, Fibrosis | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2| Inflammation, Chronic Active | 2 3 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 3 2 | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 5| 6| 7| 4| 6| 7| DAY ON TEST | 3| 3| 0| 3| 3| 8| 3| 1| 6| 0| 1| 3| 6| 0| 4| 0| 7| 3| 7| 2| 4| 3| 9| 6| 3| | 8| 3| 0| 4| 3| 9| 3| 3| 5| 2| 8| 0| 3| 1| 4| 1| 0| 3| 7| 5| 5| 3| 7| 5| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | Hyperplasia | 3 | Artery, Inflammation, Chronic Active | 2 | Interstitial Cell, Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + | Iliac, Ectasia | | Renal, Hemorrhage | 1 1 | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + M M + + + M + + M + + + M M M M + + M| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | Fibrosis | 3 2 2 2 2 2 2 2 2 | Hematopoietic Cell Proliferation | 4 | Hemorrhage | 3 | Metaplasia, Lipocyte | 2 | Necrosis | 4 | __________________________________________________________________________| Thymus | + + + + + + + + M M + + + + + + + M + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M + + M M M + M + M M + M M + + M M M + + +| Galactocele | 2 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 4 3 | Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 3 1 | Hyperplasia | 2 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Necrosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 5| 6| 7| 4| 6| 7| DAY ON TEST | 3| 3| 0| 3| 3| 8| 3| 1| 6| 0| 1| 3| 6| 0| 4| 0| 7| 3| 7| 2| 4| 3| 9| 6| 3| | 8| 3| 0| 4| 3| 9| 3| 3| 5| 2| 8| 0| 3| 1| 4| 1| 0| 3| 7| 5| 5| 3| 7| 5| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Metaplasia, Osseous | | Mineralization | 2 | Alveolar Epithelium, Hyperplasia | 2 1 1 1 1 3 1 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 4 | Thrombosis | 3 2 | Olfactory Epithelium, Atrophy | 1 1 2 1 2 2 1 3 | Olfactory Epithelium, Inflammation, | | Chronic Active | 1 1 1 | Olfactory Epithelium, Metaplasia | 1 1 1 1 | Olfactory Epithelium, Necrosis | 1 1 3 1 3 2 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Retina, Atrophy | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 3 3| Infarct | | Nephropathy | 2 3 3 2 4 2 4 4 3 4 2 4 4 4 4 4 2 3 3 2 3 4 2 4 3| Renal Tubule, Hyperplasia | 2 3 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | Inflammation, Chronic Active | | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 7| 4| 5| 7| 5| 6| 6| 6| 6| 7| 3| 7| 7| 6| 7| 5| 7| 5| 5| 6| 6| | DAY ON TEST | 5| 3| 4| 8| 3| 3| 4| 0| 5| 0| 6| 7| 0| 0| 5| 0| 3| 0| 3| 8| 3| 7| 9| 0| 5| | | 0| 7| 1| 1| 3| 7| 1| 6| 6| 0| 5| 9| 9| 7| 7| 0| 3| 8| 0| 1| 3| 5| 7| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X X | 7 | __________________________________________________________________________|____________| Intestine Large, Rectum | I + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Mineralization | | 1 2.0| Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X X X | 7 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 5 1.6| Basophilic Focus | X X X X X X X X | 17 | Clear Cell Focus | X X | 6 | Degeneration, Cystic | 2 2 2 3 3 2 2 | 18 2.2| Degeneration, Fatty | 2 2 3 | 4 2.3| Hepatodiaphragmatic Nodule | | 1 | Inflammation, Chronic | | 1 1.0| Mixed Cell Focus | | 1 | Necrosis | 2 | 2 1.5| Regeneration | 4 3 | 3 3.3| Bile Duct, Hyperplasia | 1 3 1 3 2 1 2 2 2 3 2 2 2 2 1 3 2 3 2| 40 2.0| Centrilobular, Necrosis | 1 2 1 1 1 2 1 | 13 1.5| __________________________________________________________________________|____________| Mesentery | + + + + + + +| 13 | Inflammation, Chronic Active | 4| 1 4.0| Fat, Necrosis | 3 2 2 3 2 2 4| 13 2.4| __________________________________________________________________________|____________| Oral Mucosa | | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 2 2 2 2 2 3 1 1 2 1 3 2 1 1 | 27 1.9| Basophilic Focus | X | 2 | Hyperplasia | 2 2 | 3 2.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | 2 | 1 2.0| Mineralization | | 1 2.0| Necrosis | 2 | 5 3.0| Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 7| 4| 5| 7| 5| 6| 6| 6| 6| 7| 3| 7| 7| 6| 7| 5| 7| 5| 5| 6| 6| | DAY ON TEST | 5| 3| 4| 8| 3| 3| 4| 0| 5| 0| 6| 7| 0| 0| 5| 0| 3| 0| 3| 8| 3| 7| 9| 0| 5| | | 0| 7| 1| 1| 3| 7| 1| 6| 6| 0| 5| 9| 9| 7| 7| 0| 3| 8| 0| 1| 3| 5| 7| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Mineralization | 2 1 | 5 1.8| Necrosis | | 2 3.0| __________________________________________________________________________|____________| Tooth | + | 2 | Developmental Malformation | | 1 | Inflammation, Chronic Active | 4 | 2 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 1 1 2 1 2 2 1 3 1 2 2 2 2 2 1 2 2 2 2 2 2 1| 46 2.0| Atrium, Thrombosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| Hyperplasia | 1 2 2 1 2 2 2 2 2 2 2 2 2| 25 1.8| Hypertrophy | 2 | 1 2.0| Necrosis | 2 | 2 2.5| Vacuolization Cytoplasmic | 2 3 | 4 2.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 3 2 3 2 2 | 19 2.2| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 2 2.5| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Hyperplasia | 3 2 2 2 2| 10 2.2| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Cyst | | 1 3.0| Pars Distalis, Hyperplasia | 2 3 2 | 4 2.3| Pars Intermedia, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 2 1 1 1 1 2 1 3| 24 1.5| Follicular Cell, Hyperplasia | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 3 3 3 | 3 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 7| 4| 5| 7| 5| 6| 6| 6| 6| 7| 3| 7| 7| 6| 7| 5| 7| 5| 5| 6| 6| | DAY ON TEST | 5| 3| 4| 8| 3| 3| 4| 0| 5| 0| 6| 7| 0| 0| 5| 0| 3| 0| 3| 8| 3| 7| 9| 0| 5| | | 0| 7| 1| 1| 3| 7| 1| 6| 6| 0| 5| 9| 9| 7| 7| 0| 3| 8| 0| 1| 3| 5| 7| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Hyperplasia | | 2 3.0| __________________________________________________________________________|____________| Penis | + + | 3 | Vein, Fibrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 3 2.3| Inflammation, Chronic Active | 2 2 3 | 6 2.5| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 1 | 7 1.9| Inflammation, Chronic Active | 3 2 4 | 4 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 3 4 | 4 3.5| Hyperplasia | | 1 3.0| Artery, Inflammation, Chronic Active | 2 | 2 2.0| Interstitial Cell, Hyperplasia | 1 1 | 4 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 18 | Iliac, Ectasia | 3 | 1 3.0| Renal, Hemorrhage | | 2 1.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M + M M + M + + + + + M + M + + + M + M + M + + M| 31 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + M + + + + + + + + M + + + + + + M + + + +| 45 | Infiltration Cellular, Plasma Cell | 3 | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M + M + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Spleen | | 1 | Fibrosis | 2 3 3 3 3 2 2 2 3 2 | 19 2.3| Hematopoietic Cell Proliferation | 3 | 2 3.5| Hemorrhage | | 1 3.0| Metaplasia, Lipocyte | | 1 2.0| Necrosis | 2 | 2 3.0| __________________________________________________________________________|____________| Thymus | + + + + M + M + + + + + M + + + + M M + + + + + +| 42 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + M M M + + M + M + + M M + + M + + M M M +| 23 | Galactocele | 3 | 3 2.7| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 7| 4| 5| 7| 5| 6| 6| 6| 6| 7| 3| 7| 7| 6| 7| 5| 7| 5| 5| 6| 6| | DAY ON TEST | 5| 3| 4| 8| 3| 3| 4| 0| 5| 0| 6| 7| 0| 0| 5| 0| 3| 0| 3| 8| 3| 7| 9| 0| 5| | | 0| 7| 1| 1| 3| 7| 1| 6| 6| 0| 5| 9| 9| 7| 7| 0| 3| 8| 0| 1| 3| 5| 7| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Hyperkeratosis | | 2 3.5| Inflammation, Chronic Active | 4 2 2| 4 2.3| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 3 | 4 2.5| Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Necrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 | 2 2.0| Metaplasia, Osseous | 1 | 1 1.0| Mineralization | | 1 2.0| Alveolar Epithelium, Hyperplasia | 1 2 2 2 1 2 1| 16 1.4| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 4.0| Thrombosis | 2 3 4 3 2 3 1 | 9 2.6| Olfactory Epithelium, Atrophy | 3 3 1 1| 12 1.8| Olfactory Epithelium, Inflammation, | | | Chronic Active | 1 1 | 5 1.0| Olfactory Epithelium, Metaplasia | 1 | 5 1.0| Olfactory Epithelium, Necrosis | 3 3 1 1 | 11 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Retina, Atrophy | 4 | 1 4.0| __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 3 2.7| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 7| 4| 5| 7| 5| 6| 6| 6| 6| 7| 3| 7| 7| 6| 7| 5| 7| 5| 5| 6| 6| | DAY ON TEST | 5| 3| 4| 8| 3| 3| 4| 0| 5| 0| 6| 7| 0| 0| 5| 0| 3| 0| 3| 8| 3| 7| 9| 0| 5| | | 0| 7| 1| 1| 3| 7| 1| 6| 6| 0| 5| 9| 9| 7| 7| 0| 3| 8| 0| 1| 3| 5| 7| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Infarct | 3 2 | 2 2.5| Nephropathy | 4 2 2 2 4 2 3 3 2 3 2 3 2 4 4 3 4 2 3 2 4 3 3 2 4| 50 3.0| Renal Tubule, Hyperplasia | | 3 2.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 4.0| Inflammation, Chronic Active | 3 2 | 2 2.5| Transitional Epithelium, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 6| 6| 5| 5| 5| 6| 5| 5| 7| 7| 5| 5| 5| 6| 7| 5| 5| 7| 5| 6| 5| 7| 5| 6| 4| DAY ON TEST | 2| 3| 6| 2| 6| 4| 9| 3| 3| 0| 6| 3| 6| 2| 3| 6| 2| 2| 4| 6| 6| 0| 4| 0| 6| | 0| 7| 8| 3| 9| 2| 0| 4| 3| 5| 5| 4| 9| 2| 3| 7| 8| 1| 0| 5| 9| 2| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + A + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 | Basophilic Focus | X X X X X X X X X | Clear Cell Focus | | Degeneration, Cystic | 2 2 3 3 2 1 2 3 3 1 | Degeneration, Fatty | 2 | Eosinophilic Focus | X X X | Hepatodiaphragmatic Nodule | X X X | Mixed Cell Focus | X X | Necrosis | | Regeneration | 3 2 3 | Thrombosis | 2 | Bile Duct, Hyperplasia | 2 2 2 2 3 2 2 3 1 3 2 2 3 2 1 2 1 1| Centrilobular, Necrosis | 1 1 1 1 1 3 1 1 | __________________________________________________________________________| Mesentery | + + + + + + + + + + + | Artery, Mineralization | | Fat, Necrosis | 3 2 2 2 2 2 2 2 2 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 2 1 2 2 2 2 2 1 2 1 2 1 2 1| Basophilic Focus | X | Hyperplasia | 2 2 2 2 | Artery, Inflammation | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Mineralization | | Necrosis | 2 | Ulcer | 4 4 | __________________________________________________________________________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 | Necrosis | 2 2 3 | __________________________________________________________________________| Tongue | + + | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 6| 6| 5| 5| 5| 6| 5| 5| 7| 7| 5| 5| 5| 6| 7| 5| 5| 7| 5| 6| 5| 7| 5| 6| 4| DAY ON TEST | 2| 3| 6| 2| 6| 4| 9| 3| 3| 0| 6| 3| 6| 2| 3| 6| 2| 2| 4| 6| 6| 0| 4| 0| 6| | 0| 7| 8| 3| 9| 2| 0| 4| 3| 5| 5| 4| 9| 2| 3| 7| 8| 1| 0| 5| 9| 2| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 1 2 3 3 2 2 1 2 1 2 3 1 3 2 2 1 3 2| Artery, Mineralization | 2 | Atrium, Thrombosis | 3 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + A + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 1 2 2 2 2 2 1 2 2 | Hypertrophy | 2 | Necrosis | | Vacuolization Cytoplasmic | 3 3 | __________________________________________________________________________| Adrenal Medulla | + + A + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 1 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 4 1 2 3 3 3 3 2| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 2 | __________________________________________________________________________| Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 1 1 1 1 1 1 1 | Follicular Cell, Hyperplasia | 1 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 | Hyperplasia | | Necrosis, Fatty | 3 | __________________________________________________________________________| Preputial Gland | + + A + + + + + + + + + + + + + M + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 3 3 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | | Mineralization | | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 6| 6| 5| 5| 5| 6| 5| 5| 7| 7| 5| 5| 5| 6| 7| 5| 5| 7| 5| 6| 5| 7| 5| 6| 4| DAY ON TEST | 2| 3| 6| 2| 6| 4| 9| 3| 3| 0| 6| 3| 6| 2| 3| 6| 2| 2| 4| 6| 6| 0| 4| 0| 6| | 0| 7| 8| 3| 9| 2| 0| 4| 3| 5| 5| 4| 9| 2| 3| 7| 8| 1| 0| 5| 9| 2| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 | Artery, Inflammation, Chronic Active | 3 2 2 2 | Interstitial Cell, Hyperplasia | 1 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + | Pancreatic, Hemorrhage | 2 | Renal, Hemorrhage | 2 2 2 | Renal, Infiltration Cellular, Plasma | | Cell | | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + + + + + M + + + + + + + + + + + + M +| __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + M + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + M + + + + + + +| Hemorrhage | 3 | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | __________________________________________________________________________| Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | Fibrosis | 2 3 3 3 2 2 3 2 2 3 | Hematopoietic Cell Proliferation | 2 | Necrosis | 2 3 | Thrombosis | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + M M M + + + M + M + + + + M M + M + + +| Galactocele | 3 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 3 3 4 4| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 2 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + A + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 6| 6| 5| 5| 5| 6| 5| 5| 7| 7| 5| 5| 5| 6| 7| 5| 5| 7| 5| 6| 5| 7| 5| 6| 4| DAY ON TEST | 2| 3| 6| 2| 6| 4| 9| 3| 3| 0| 6| 3| 6| 2| 3| 6| 2| 2| 4| 6| 6| 0| 4| 0| 6| | 0| 7| 8| 3| 9| 2| 0| 4| 3| 5| 5| 4| 9| 2| 3| 7| 8| 1| 0| 5| 9| 2| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hemorrhage | 3 | Inflammation, Chronic Active | 3 | Mineralization | | Alveolar Epithelium, Hyperplasia | 3 3 1 2 2 4 | Artery, Mediastinum, Mineralization | | __________________________________________________________________________| Nose | + + A + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 2 2 | Thrombosis | 3 | Olfactory Epithelium, Atrophy | 3 3 2 2 2 3 2 2 2 2 2 2 2 2 1 1 3 2 2 3 3 3 | Olfactory Epithelium, Hyperplasia, | | Basal Cell | 2 2 3 1 2 2 2 2 2 1 2 1 1 1 1 1 2 1 1 3 2 2 1| Olfactory Epithelium, Hyperplasia, | | Adenomatous | | Olfactory Epithelium, Inflammation, | | Chronic Active | 1 1 2 | Olfactory Epithelium, Metaplasia | 1 3 1 2 2 1 2 2 2 2 2 2 2 2 1 1 2 2 2 3 2 2 | Olfactory Epithelium, Necrosis | 3 2 2 3 1 3 1 1 2 3 3 2 3 2| Turbinate, Fibrosis, Focal | 1 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 3 | Retina, Atrophy | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 | Infarct | 3 | Mineralization | 2 | Nephropathy | 4 2 2 2 2 3 3 2 4 4 3 3 3 3 4 2 2 4 2 4 3 4 2 4 3| Renal Tubule, Hyperplasia | 3 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| 7| 7| 6| 6| 6| 5| 5| 5| 7| 7| 5| 6| 5| 6| 6| 5| 4| 6| 4| | DAY ON TEST | 7| 0| 2| 2| 9| 0| 0| 3| 8| 2| 5| 9| 6| 1| 3| 3| 8| 8| 2| 0| 2| 8| 9| 6| 6| | | 9| 6| 5| 1| 7| 5| 7| 3| 1| 2| 2| 5| 1| 2| 3| 3| 4| 1| 4| 9| 2| 5| 7| 7| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + I + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 3.0| Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + A + + + + + + + + + + + + + + + + + + + + A| 46 | Parasite Metazoan | X X | 7 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + A + + + + + + + + + + + + + + + + + + + + A| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + A + + + + + + + + + + + + + + + + + + + + A| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 2 1 2 2 | 6 1.7| Basophilic Focus | X X X X X X X X X X X X | 21 | Clear Cell Focus | X X X | 3 | Degeneration, Cystic | 2 2 1 2 1 2 2 2 1 2 | 20 2.0| Degeneration, Fatty | 3 2 2 | 4 2.3| Eosinophilic Focus | | 3 | Hepatodiaphragmatic Nodule | X | 4 | Mixed Cell Focus | | 2 | Necrosis | 2 | 1 2.0| Regeneration | | 3 2.7| Thrombosis | | 1 2.0| Bile Duct, Hyperplasia | 3 2 1 2 1 1 1 2 1 1 3 3 2 2 3 2 2| 35 1.9| Centrilobular, Necrosis | 2 2 1 1 1 | 13 1.3| __________________________________________________________________________|____________| Mesentery | + + + + + + + | 18 | Artery, Mineralization | 3 | 1 3.0| Fat, Necrosis | 2 2 2 2 2 | 14 2.1| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 2 2 2 2 1 2 1 3 1 3 2 2 1 1 | 30 1.7| Basophilic Focus | X| 2 | Hyperplasia | 2 | 5 2.0| Artery, Inflammation | 4 | 2 3.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | 2 3 | 2 2.5| Mineralization | 2 | 1 2.0| Necrosis | 2 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| 7| 7| 6| 6| 6| 5| 5| 5| 7| 7| 5| 6| 5| 6| 6| 5| 4| 6| 4| | DAY ON TEST | 7| 0| 2| 2| 9| 0| 0| 3| 8| 2| 5| 9| 6| 1| 3| 3| 8| 8| 2| 0| 2| 8| 9| 6| 6| | | 9| 6| 5| 1| 7| 5| 7| 3| 1| 2| 2| 5| 1| 2| 3| 3| 4| 1| 4| 9| 2| 5| 7| 7| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Ulcer | 3 4 3 4 | 6 3.7| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | 3 2 | 3 2.7| Necrosis | 4 2 2 | 6 2.5| __________________________________________________________________________|____________| Tongue | + + | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + | 3 | Aorta, Mineralization | 4 | 2 3.5| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 1 2 4 2 2 2 2 1 2 2 2 2 3 2 2| 39 2.0| Artery, Mineralization | 4 | 2 3.0| Atrium, Thrombosis | 4 4 | 4 3.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 1 3 2 2 1 2 2 2 2 2 2 2 | 26 1.9| Hypertrophy | | 1 2.0| Necrosis | 3 | 1 3.0| Vacuolization Cytoplasmic | 3 | 3 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 3 2 1 2 1 2 2 3 3 1 2 1 2 | 19 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 | 3 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 2 4 3 3 1 3 2 | 19 2.4| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 3 3 2 | 5 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 1 1 2 1 3 2 1 1 1 1 2 1 2 2 | 23 1.3| Follicular Cell, Hyperplasia | 2 | 4 1.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + | 3 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | | 1 2.0| Hyperplasia | 3 3 3 3 3 3 | 6 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| 7| 7| 6| 6| 6| 5| 5| 5| 7| 7| 5| 6| 5| 6| 6| 5| 4| 6| 4| | DAY ON TEST | 7| 0| 2| 2| 9| 0| 0| 3| 8| 2| 5| 9| 6| 1| 3| 3| 8| 8| 2| 0| 2| 8| 9| 6| 6| | | 9| 6| 5| 1| 7| 5| 7| 3| 1| 2| 2| 5| 1| 2| 3| 3| 4| 1| 4| 9| 2| 5| 7| 7| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Necrosis, Fatty | | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 1 | 1 1.0| Inflammation, Chronic Active | 4 2 | 3 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 2 2 2 | 5 1.8| Inflammation, Chronic Active | 3 | 4 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 3 | 1 3.0| Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 4 3 | 4 3.3| Artery, Inflammation, Chronic Active | | 4 2.3| Interstitial Cell, Hyperplasia | 1 1 1 1 3 2 | 9 1.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + | 11 | Pancreatic, Hemorrhage | | 1 2.0| Renal, Hemorrhage | | 3 2.0| Renal, Infiltration Cellular, Plasma | | | Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + + + + + + + + + + + + + + + + + + M + + M| 44 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M + + + M + + + + + M + + M + +| 44 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemorrhage | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | Hemorrhage | | 1 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Accessory Spleen | | 1 | Fibrosis | 2 2 2 2 3 2 3 | 17 2.4| Hematopoietic Cell Proliferation | 4 3 | 3 3.0| Necrosis | 3 | 3 2.7| Thrombosis | 1 | 1 1.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + M + + + + + + M + M + + + +| 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M + + + + + + M + + M + + M M + M M + M + + M M| 30 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| 7| 7| 6| 6| 6| 5| 5| 5| 7| 7| 5| 6| 5| 6| 6| 5| 4| 6| 4| | DAY ON TEST | 7| 0| 2| 2| 9| 0| 0| 3| 8| 2| 5| 9| 6| 1| 3| 3| 8| 8| 2| 0| 2| 8| 9| 6| 6| | | 9| 6| 5| 1| 7| 5| 7| 3| 1| 2| 2| 5| 1| 2| 3| 3| 4| 1| 4| 9| 2| 5| 7| 7| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Galactocele | 3 | 3 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 3 3 | 8 3.1| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 1 4 2 1 2 | 7 2.1| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | | 2 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | | 1 3.0| Inflammation, Chronic Active | | 1 3.0| Mineralization | 3 | 1 3.0| Alveolar Epithelium, Hyperplasia | 1 1 1 1 2 2 1 2 | 14 1.9| Artery, Mediastinum, Mineralization | 3 | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 3 | 4 2.3| Thrombosis | 4 2 | 3 3.0| Olfactory Epithelium, Atrophy | 2 1 3 1 1 3 3 4 1 4 2 2 3 3 2 1 2 1 1 3 3 1 3 2 | 46 2.2| Olfactory Epithelium, Hyperplasia, | | | Basal Cell | 1 1 2 2 2 1 2 1 2 1 1 2 2 1 1 | 38 1.6| Olfactory Epithelium, Hyperplasia, | | | Adenomatous | 2 | 1 2.0| Olfactory Epithelium, Inflammation, | | | Chronic Active | 3 3 1 1 1 1 | 9 1.6| Olfactory Epithelium, Metaplasia | 1 2 1 1 2 3 4 1 2 2 1 2 3 1 1 2 1 1 2 1 1 2 1 | 45 1.8| Olfactory Epithelium, Necrosis | 1 2 2 2 1 2 1 3 1 2 3 1 | 26 2.0| Turbinate, Fibrosis, Focal | 1 1 | 5 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cataract | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| 7| 7| 6| 6| 6| 5| 5| 5| 7| 7| 5| 6| 5| 6| 6| 5| 4| 6| 4| | DAY ON TEST | 7| 0| 2| 2| 9| 0| 0| 3| 8| 2| 5| 9| 6| 1| 3| 3| 8| 8| 2| 0| 2| 8| 9| 6| 6| | | 9| 6| 5| 1| 7| 5| 7| 3| 1| 2| 2| 5| 1| 2| 3| 3| 4| 1| 4| 9| 2| 5| 7| 7| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | Retina, Atrophy | | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 3 2.0| Infarct | 3 | 2 3.0| Mineralization | 3 | 2 2.5| Nephropathy | 3 2 4 4 1 4 4 4 4 4 4 3 4 2 3 4 4 3 2 3 4 2 3 3 2| 50 3.1| Renal Tubule, Hyperplasia | 3 4 2 1 | 6 2.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 5| 5| 7| 6| 6| 6| 6| 6| 5| 5| 5| 6| 7| 6| 7| 6| 3| 6| 6| 6| 7| 5| 4| 6| 5| DAY ON TEST | 2| 5| 3| 0| 6| 7| 4| 4| 9| 4| 6| 2| 3| 9| 3| 2| 0| 0| 0| 6| 3| 3| 6| 1| 8| | 2| 8| 3| 9| 3| 3| 9| 6| 7| 9| 7| 5| 3| 3| 3| 5| 7| 3| 1| 7| 3| 0| 3| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + I + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 3 2 | Basophilic Focus | X X X X X X X X X| Clear Cell Focus | X X | Degeneration, Cystic | 1 2 2 1 1 2 2 3 3 1 2 2 2| Degeneration, Fatty | 2 | Eosinophilic Focus | X X| Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | | Necrosis | 2 | Bile Duct, Hyperplasia | 2 1 2 1 2 2 1 1 2 3 3 3 1 2 1 1 2 1 2 3 | Centrilobular, Necrosis | 3 2 2 4 | __________________________________________________________________________| Mesentery | + + + + + + + | Inflammation, Chronic Active | 4 | Fat, Necrosis | 2 2 2 2 3 | __________________________________________________________________________| Oral Mucosa | + + + | Pharyngeal, Hyperplasia, Squamous | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 1 2 2 2 1 2 1 2 2 2 | Basophilic Focus | | Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 2 | Inflammation, Chronic Active | 2 2 3 3 3 | Necrosis | 2 2 | Ulcer | 3 4 2 3 3 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 1 3 3 | Necrosis | 2 | __________________________________________________________________________| Tongue | + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 5| 5| 7| 6| 6| 6| 6| 6| 5| 5| 5| 6| 7| 6| 7| 6| 3| 6| 6| 6| 7| 5| 4| 6| 5| DAY ON TEST | 2| 5| 3| 0| 6| 7| 4| 4| 9| 4| 6| 2| 3| 9| 3| 2| 0| 0| 0| 6| 3| 3| 6| 1| 8| | 2| 8| 3| 9| 3| 3| 9| 6| 7| 9| 7| 5| 3| 3| 3| 5| 7| 3| 1| 7| 3| 0| 3| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Aorta, Mineralization | 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 2 1 2 3 2 2 2 1 2 2 2 2 1 1 2 3 2 2 2 2 1| Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 1 2 2 2 2 2 2 2 1 2| Hypertrophy | 2 | Necrosis | 2 | Vacuolization Cytoplasmic | 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 1 2 2 3 2 3 2 2 1 3 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2 3 1 2 3 3 4 3 4 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 4 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 2 1 2 2 1 1 | Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 | Inflammation, Chronic Active | 4 2 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Artery, Inflammation, Chronic Active | 2 3 | Interstitial Cell, Hyperplasia | 1 1 1 1 1 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 5| 5| 7| 6| 6| 6| 6| 6| 5| 5| 5| 6| 7| 6| 7| 6| 3| 6| 6| 6| 7| 5| 4| 6| 5| DAY ON TEST | 2| 5| 3| 0| 6| 7| 4| 4| 9| 4| 6| 2| 3| 9| 3| 2| 0| 0| 0| 6| 3| 3| 6| 1| 8| | 2| 8| 3| 9| 3| 3| 9| 6| 7| 9| 7| 5| 3| 3| 3| 5| 7| 3| 1| 7| 3| 0| 3| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + + | Renal, Ectasia | | Renal, Hemorrhage | 2 2 | Renal, Pigmentation | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + M + M + + + + + + + + + + M + M + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 2 2 3 3 2 2 3 | Hematopoietic Cell Proliferation | 3 4 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + M M M + M M + M M + M + + M M M + + + + M +| Galactocele | 3| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Inflammation, Chronic Active | 3 3 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 2 3 1 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 3 | Mineralization | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X | Hemorrhage | | Inflammation, Chronic Active | 1 | Mineralization | 2 | Alveolar Epithelium, Hyperplasia | 1 1 2 1 1 1 1 1 1 2 4 1 1| Artery, Mediastinum, Mineralization | 2 | __________________________________________________________________________| Nose | + + + + + A + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Thrombosis | 2 | _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 _____________________________________________________________________________________________________________________ | 5| 5| 7| 6| 6| 6| 6| 6| 5| 5| 5| 6| 7| 6| 7| 6| 3| 6| 6| 6| 7| 5| 4| 6| 5| DAY ON TEST | 2| 5| 3| 0| 6| 7| 4| 4| 9| 4| 6| 2| 3| 9| 3| 2| 0| 0| 0| 6| 3| 3| 6| 1| 8| | 2| 8| 3| 9| 3| 3| 9| 6| 7| 9| 7| 5| 3| 3| 3| 5| 7| 3| 1| 7| 3| 0| 3| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Olfactory Epithelium, Atrophy | 4 4 3 4 4 4 4 4 3 3 3 4 4 4 4 3 4 4 4 4 3 3 4 3| Olfactory Epithelium, Fibrosis | 2 3 3 4 3 3 4 3 2 2 3 3 3 3 4 3 2 3 2 3 3 3 3| Olfactory Epithelium, Hyperplasia, | | Basal Cell | 1 2 2 3 3 3 3 1 1 2 3 2 3 3 2 3 2 2 1 2 3 2 2| Olfactory Epithelium, Hyperplasia, | | Adenomatous | 2 2 2 1 2 2 2 1 2 2 2 3 3 3 1 3 1 3 3 2 2| Olfactory Epithelium, Inflammation, | | Chronic Active | 3 2 2 3 2 2 3 3 3 3 3 4 3 2 4 2 4 2 4 4 3 3 2 2| Olfactory Epithelium, Metaplasia | 3 4 3 4 4 3 4 3 3 3 3 4 4 3 4 3 4 4 4 4 2 2 3 2| Olfactory Epithelium, Necrosis | 1 1 3 3 3 3 2 3 | Respiratory Epithelium, Hyperplasia | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | External Ear, Inflammation, Chronic | | Active | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Hyperplasia, Oncocytic | 1 | Mineralization | | Nephropathy | 4 4 4 2 4 4 4 4 4 3 4 4 4 4 4 3 1 4 3 4 4 3 2 4 3| Pelvis, Inflammation, Acute | | Renal Tubule, Hyperplasia | 4 | Transitional Epithelium, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + I + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 6| 3| 6| 6| 5| 6| 7| 6| 6| 7| 5| 5| 5| 4| 5| 6| 6| 7| 4| 6| 7| | DAY ON TEST | 1| 2| 6| 3| 5| 0| 0| 1| 7| 6| 0| 7| 2| 0| 3| 7| 4| 7| 3| 5| 9| 2| 9| 6| 1| | | 7| 8| 3| 9| 1| 5| 8| 3| 8| 0| 2| 2| 5| 2| 3| 6| 0| 0| 2| 1| 1| 8| 7| 0| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Parasite Metazoan | X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | Parasite Metazoan | X X X X | 6 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + A + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + A + + + + + + + + + + + + A + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 1 | 5 1.8| Basophilic Focus | X X X X | 13 | Clear Cell Focus | | 2 | Degeneration, Cystic | 2 2 1 2 2 2 2 3 | 21 1.9| Degeneration, Fatty | 2 2 | 3 2.0| Eosinophilic Focus | X X | 4 | Hepatodiaphragmatic Nodule | X | 3 | Mixed Cell Focus | X | 1 | Necrosis | | 1 2.0| Bile Duct, Hyperplasia | 3 1 2 1 1 2 1 2 2 2 3 3 3 2| 34 1.9| Centrilobular, Necrosis | 1 1 1 2 | 8 2.0| __________________________________________________________________________|____________| Mesentery | + + + + + +| 13 | Inflammation, Chronic Active | | 1 4.0| Fat, Necrosis | 2 2 2 2 2 3| 11 2.2| __________________________________________________________________________|____________| Oral Mucosa | + + + + | 7 | Pharyngeal, Hyperplasia, Squamous | 3 2 | 3 2.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 2 1 1 2 2 3 2 2 2 3 2| 23 1.9| Basophilic Focus | X | 1 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | | 1 2.0| Inflammation, Chronic Active | | 5 2.6| Necrosis | 3 | 3 2.3| Ulcer | 4 3 4 3 4 | 11 3.4| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 3| 5 2.4| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 61 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 6| 3| 6| 6| 5| 6| 7| 6| 6| 7| 5| 5| 5| 4| 5| 6| 6| 7| 4| 6| 7| | DAY ON TEST | 1| 2| 6| 3| 5| 0| 0| 1| 7| 6| 0| 7| 2| 0| 3| 7| 4| 7| 3| 5| 9| 2| 9| 6| 1| | | 7| 8| 3| 9| 1| 5| 8| 3| 8| 0| 2| 2| 5| 2| 3| 6| 0| 0| 2| 1| 1| 8| 7| 0| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Necrosis | 3 | 2 2.5| __________________________________________________________________________|____________| Tongue | + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Aorta, Mineralization | | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 2 2 2 3 1 2 2 2 2 2 1 2 2 1 2 3 2 2 1 2| 45 1.8| Atrium, Thrombosis | 3 | 2 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 1 2 2 2 2 3 1 2 2| 23 1.8| Hypertrophy | | 1 2.0| Necrosis | 3 | 2 2.5| Vacuolization Cytoplasmic | | 2 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 2 2 1 | 17 2.1| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 | 3 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 1 2 3 3 3 1 2 3 4 3| 24 2.5| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + I + + +| 49 | Pars Distalis, Hyperplasia | | 2 3.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 2 1 1 | 28 1.1| Follicular Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 1 3.0| Inflammation, Chronic Active | 2 3 2 2 | 4 2.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 | 4 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 62 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 6| 3| 6| 6| 5| 6| 7| 6| 6| 7| 5| 5| 5| 4| 5| 6| 6| 7| 4| 6| 7| | DAY ON TEST | 1| 2| 6| 3| 5| 0| 0| 1| 7| 6| 0| 7| 2| 0| 3| 7| 4| 7| 3| 5| 9| 2| 9| 6| 1| | | 7| 8| 3| 9| 1| 5| 8| 3| 8| 0| 2| 2| 5| 2| 3| 6| 0| 0| 2| 1| 1| 8| 7| 0| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic Active | 3 2 | 5 2.6| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 1 3.0| Artery, Inflammation, Chronic Active | 2 | 3 2.3| Interstitial Cell, Hyperplasia | 1 | 7 1.1| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + +| 15 | Renal, Ectasia | 2 | 1 2.0| Renal, Hemorrhage | 2 2 2 | 5 2.0| Renal, Pigmentation | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + + + M M + + + + + + + M + + +| 43 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Infiltration Cellular, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Plasma Cell | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + M + + + + + + + + + + + + + M + + + + +| 47 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 3 1 2 2 2 3 2 2 3 2| 20 2.3| Hematopoietic Cell Proliferation | 2 2 3 | 6 2.8| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + M M + M + M M M + M + M + + + + + +| 28 | Galactocele | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis | 3 | 1 3.0| Inflammation, Chronic Active | 4 2 | 5 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 2 2 2 2 2| 11 2.2| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 63 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 6| 3| 6| 6| 5| 6| 7| 6| 6| 7| 5| 5| 5| 4| 5| 6| 6| 7| 4| 6| 7| | DAY ON TEST | 1| 2| 6| 3| 5| 0| 0| 1| 7| 6| 0| 7| 2| 0| 3| 7| 4| 7| 3| 5| 9| 2| 9| 6| 1| | | 7| 8| 3| 9| 1| 5| 8| 3| 8| 0| 2| 2| 5| 2| 3| 6| 0| 0| 2| 1| 1| 8| 7| 0| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Mineralization | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Acute | 4 | 1 4.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | | 1 | Hemorrhage | 3 | 1 3.0| Inflammation, Chronic Active | | 1 1.0| Mineralization | | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 1 1 1 1 2 2 1 2 1 1 1 | 25 1.4| Artery, Mediastinum, Mineralization | 2| 2 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | | 1 3.0| Thrombosis | 2 | 2 2.0| Olfactory Epithelium, Atrophy | 3 3 3 3 4 2 4 3 3 4 4 4 3 3 4 4 4 3 4 4 4 3 4 4| 48 3.6| Olfactory Epithelium, Fibrosis | 3 2 3 2 3 3 3 2 2 3 4 2 3 3 3 3 2 2 2 2 2 1 3 2| 47 2.7| Olfactory Epithelium, Hyperplasia, | | | Basal Cell | 3 1 2 2 3 3 3 1 2 2 2 1 3 3 4 3 3 1 2 2 2 3 1| 46 2.2| Olfactory Epithelium, Hyperplasia, | | | Adenomatous | 2 2 1 1 1 2 2 3 3 2 2 2 1 2 1 2 2 3 1 1 3| 42 2.0| Olfactory Epithelium, Inflammation, | | | Chronic Active | 2 2 3 1 1 2 3 3 2 2 4 3 2 1 2 3 4 2 3 4 2 4 2 3 3| 49 2.7| Olfactory Epithelium, Metaplasia | 2 3 2 2 3 2 3 2 2 3 4 4 2 3 4 3 4 3 3 4 3 2 3 3| 48 3.1| Olfactory Epithelium, Necrosis | 3 3 4 2 2 3 1 1 1 1 2 | 19 2.2| Respiratory Epithelium, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | External Ear, Inflammation, Chronic | | | Active | 4 | 1 4.0| __________________________________________________________________________|____________| Zymbal's Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 2 2 2| 5 2.2| Hyperplasia, Oncocytic | 4 | 2 2.5| Mineralization | 2| 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 64 NTP Experiment-Test: 05136-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 09/13/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:12:27 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 6| 3| 6| 6| 5| 6| 7| 6| 6| 7| 5| 5| 5| 4| 5| 6| 6| 7| 4| 6| 7| | DAY ON TEST | 1| 2| 6| 3| 5| 0| 0| 1| 7| 6| 0| 7| 2| 0| 3| 7| 4| 7| 3| 5| 9| 2| 9| 6| 1| | | 7| 8| 3| 9| 1| 5| 8| 3| 8| 0| 2| 2| 5| 2| 3| 6| 0| 0| 2| 1| 1| 8| 7| 0| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Nephropathy | 3 3 4 4 4 1 4 3 3 4 4 4 3 4 4 4 3 4 3 3 3 4 3 4 4| 50 3.5| Pelvis, Inflammation, Acute | 2 | 1 2.0| Renal Tubule, Hyperplasia | 1 1 1 1 3 | 6 1.8| Transitional Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 4 | 1 4.0| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 65 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------