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TDMS Study 05136-07 Pathology Tables

NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27

                                                           CORE STUDY




       Facility:  Battelle Northwest

       Chemical CAS #:  0000126-99-8

       Lock Date:  05/04/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1

NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 2| 4| 6| 3| 3| 9| 3| 2| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 0|             
                                           | 1| 4| 6| 5| 4| 7| 5| 2| 4| 1| 4| 1| 5| 5| 4| 4| 4| 4| 5| 4| 3| 3| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X           X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 3                                                                        |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Parasite Metazoan                    | X                          X              X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                       X                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1                                               2                     |             
      Basophilic Focus                     | X  X     X  X  X  X  X  X        X  X  X  X  X  X  X  X  X  X  X  X  X   |             
      Clear Cell Focus                     |                         X     X     X     X  X  X  X  X  X  X        X   |             
      Degeneration, Fatty                  | 2     3              3     2                                             |             
      Eosinophilic Focus                   |                                                                   X      |             
      Hepatodiaphragmatic Nodule           |                            X                             X              X|             
      Mixed Cell Focus                     |             X           X                          X                     |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |                   2     1              1     1                       1  1|             
      Centrilobular, Necrosis              |    1                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Inflammation, Chronic Active         |                                                                          |             
      Fat, Necrosis                        |             2                                                            |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1                       1  2                          2  3  2|             
      Basophilic Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                      1                                                   |             
      Mineralization                       |                                                                          |             
      Ulcer                                |       3                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                     1                                    |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                           +                              |             
      Hyperplasia, Squamous                |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1     2     2  1  1  1  1     1  2  1     2           1  1  2  1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 2| 4| 6| 3| 3| 9| 3| 2| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 0|             
                                           | 1| 4| 6| 5| 4| 7| 5| 2| 4| 1| 4| 1| 5| 5| 4| 4| 4| 4| 5| 4| 3| 3| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic        |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                 2  2     2  2  2     2        1     1        2  2   |             
      Hypertrophy                          |                      2        2           1              2        2  1   |             
      Necrosis                             |                                                                2         |             
      Vacuolization Cytoplasmic            |                      1  2  2                       1              2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1                             2  2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    2  2                                2     2                 2        3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1  1  2  2        2  1  1  2  1  1  3  1  2     1  2  1  1  1  2  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                           3           2           1      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            2  2                             2            |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  M  +  +  M  +  +  +  M  +  M  +  M  +  M  +  +  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |       2              3     3                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 2| 4| 6| 3| 3| 9| 3| 2| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 0|             
                                           | 1| 4| 6| 5| 4| 7| 5| 2| 4| 1| 4| 1| 5| 5| 4| 4| 4| 4| 5| 4| 3| 3| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                               2                             3            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                        2                    2            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               4                       1  2        1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Cataract                             |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 3  1  2  2  2  2  1  1  2  2  2  2  2  2  2  2  2  1  2  2  2     2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 7| 2| 6| 5| 4| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 0| 3| 5| 8| 3| 3| 3| 2| 6| 8| 3| 3| 6| 8| 3| 3| 6| 3| 7| 3| 3| 3| 5|            |
                                           | 4| 5| 2| 5| 3| 9| 4| 4| 4| 6| 5| 1| 2| 3| 1| 7| 3| 4| 5| 5| 0| 5| 5| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                       X  X               |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                         2|      2  2.5|
      Parasite Metazoan                    |                         X                    X                           |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Acute                  |                               2                                          |      1  2.0|
      Parasite Metazoan                    |                                        X              X                  |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                             1            |      3  1.3|
      Basophilic Focus                     |    X  X  X     X  X  X  X              X  X  X  X  X  X  X     X  X  X  X|     39     |
      Clear Cell Focus                     |    X                    X                 X                          X   |     15     |
      Degeneration, Fatty                  |                                     3                                    |      5  2.6|
      Eosinophilic Focus                   |          X                                                               |      2     |
      Hepatodiaphragmatic Nodule           |                                              X                           |      4     |
      Mixed Cell Focus                     |                                                       X  X  X           X|      7     |
      Necrosis                             |                                                          2               |      1  2.0|
      Bile Duct, Hyperplasia               | 2                                2                                1      |      9  1.3|
      Centrilobular, Necrosis              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +     +                       +  +                        |   5        |
      Inflammation, Chronic Active         |                3                                                         |      1  3.0|
      Fat, Necrosis                        |                      2                       2  2                        |      4  2.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 2  1  2           1     1        2  2     1           1  1  2           1|     18  1.6|
      Basophilic Focus                     |                                                                      X   |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Squamous                |                                                                          |      1  1.0|
      Mineralization                       |                                           2                              |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   5                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 7| 2| 6| 5| 4| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 0| 3| 5| 8| 3| 3| 3| 2| 6| 8| 3| 3| 6| 8| 3| 3| 6| 3| 7| 3| 3| 3| 5|            |
                                           | 4| 5| 2| 5| 3| 9| 4| 4| 4| 6| 5| 1| 2| 3| 1| 7| 3| 4| 5| 5| 0| 5| 5| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Squamous                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 1  1  2  1  1  1     1  2     1           2  1  2  1  1  2  1  1  2  1  1|     38  1.3|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    1     2     2  2  2  1           2              1           2  2  2  2|     23  1.8|
      Hypertrophy                          |                                                    1           1         |      8  1.5|
      Necrosis                             |       2                                                                  |      2  2.0|
      Vacuolization Cytoplasmic            |    1                             2                             1  1      |      9  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       2           2                 2           1                        |      7  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           |          3                          2           2                        |      9  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 2  3  1     1  1  1  1  1     1  2  1     1              1  2  1  2  2  2|     38  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                      2                                                  1|      2  1.5|
      Inflammation, Chronic Active         |       3                                                                  |      4  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                         3                    3        3        4         |      7  2.7|
      Inflammation, Granulomatous          | 3  3                                                                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                          3           1   |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 7| 2| 6| 5| 4| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 0| 3| 5| 8| 3| 3| 3| 2| 6| 8| 3| 3| 6| 8| 3| 3| 6| 3| 7| 3| 3| 3| 5|            |
                                           | 4| 5| 2| 5| 3| 9| 4| 4| 4| 6| 5| 1| 2| 3| 1| 7| 3| 4| 5| 5| 0| 5| 5| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  M     +  +  +  M  +  +  +  M  +  +  +  +  +  M  +|  35        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|  44        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosis                             |       4                                            2                     |      3  2.7|
      Hematopoietic Cell Proliferation     |                4                                                         |      1  4.0|
      Hemorrhage                           |                                     3                                    |      4  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Galactocele                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       |          3                                                               |      1  3.0|
      Inflammation, Acute                  |                   1                                                      |      1  1.0|
      Inflammation, Chronic Active         |                                                          2               |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperostosis                         |    2              2                                                      |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |          1                                                               |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                     1                                2   |      6  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 7| 2| 6| 5| 4| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 0| 3| 5| 8| 3| 3| 3| 2| 6| 8| 3| 3| 6| 8| 3| 3| 6| 3| 7| 3| 3| 3| 5|            |
                                           | 4| 5| 2| 5| 3| 9| 4| 4| 4| 6| 5| 1| 2| 3| 1| 7| 3| 4| 5| 5| 0| 5| 5| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |                3                                                         |      1  3.0|
      Nephropathy                          |    2  2  2        2  1  3        1     2  2  3  2  2  2  1  2  2  2  2  2|     43  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                     4                                    |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 3| 3| 6| 3| 9| 8| 6| 3| 3| 2| 6| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 7| 3|             
                                           | 5| 1| 4| 5| 5| 3| 4| 1| 7| 0| 4| 1| 5| 5| 4| 5| 4| 2| 4| 4| 5| 7| 3| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Parasite Metazoan                    |                                     X                                X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2  1                          1              2           1   |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X     X  X  X|             
      Clear Cell Focus                     |                X              X        X  X  X  X     X                 X|             
      Degeneration, Fatty                  |                   2        3                                             |             
      Hepatodiaphragmatic Nodule           |                                                                   X     X|             
      Mixed Cell Focus                     | X                                                                        |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |             1     2                                            2        1|             
      Centrilobular, Necrosis              |    2                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +           +                    +        +                  |             
      Fat, Necrosis                        |             2           2                    2        2                  |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                      +                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1  1           2  1                    2                 1            |             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |          2                                                               |             
      Lipomatosis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                   2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                      +                                                   |             
      Hyperplasia, Squamous                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1  1  1  1     1  1  1  1  2     1  1  2  1     2  1  2     2  1  1|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 3| 3| 6| 3| 9| 8| 6| 3| 3| 2| 6| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 7| 3|             
                                           | 5| 1| 4| 5| 5| 3| 4| 1| 7| 0| 4| 1| 5| 5| 4| 5| 4| 2| 4| 4| 5| 7| 3| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |          2                 2     2  1  2        1     1     2     2  2   |             
      Hypertrophy                          | 2  3        2           1              2  1                              |             
      Vacuolization Cytoplasmic            | 1           3                 1        1                 2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1  2     2                    2              2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                               1                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                         2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      C-Cell, Hyperplasia                  | 1  2     1  1  1  1  2  1  2  1  2  2  2        2     2  3     2  1  2  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |       4                    4                    3                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2           2                                2                           |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Hypertrophy                  |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  M  +  +  M  M  +  +  +  M  M  +  +  +  +  +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |       X                                                                  |             
      Fibrosis                             |             2                                                            |             
      Hematopoietic Cell Proliferation     |                                  2                 4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 3| 3| 6| 3| 9| 8| 6| 3| 3| 2| 6| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 7| 3|             
                                           | 5| 1| 4| 5| 5| 3| 4| 1| 7| 0| 4| 1| 5| 5| 4| 5| 4| 2| 4| 4| 5| 7| 3| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             3                                3        2                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |          2                          3                                   4|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Chronic                  |                                                                          |             
      Hemorrhage                           |                         1                                                |             
      Inflammation, Chronic Active         |          2                                                               |             
      Alveolar Epithelium, Hyperplasia     |    2  1  2                    1        1     1  2        1  3  2  1     1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   2                                                      |             
      Thrombosis                           |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Turbinate, Fibrosis, Focal           |                            1                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Nephropathy                          | 3  2  2  3  2  2  2  2  1  2  3  1  2  3  2  2  2     3     2  2  2  1  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 9| 8| 5| 2| 3| 0| 3| 3| 3| 2| 8| 0| 3| 3|            |
                                           | 4| 5| 4| 5| 5| 2| 9| 4| 4| 4| 3| 1| 1| 7| 1| 3| 7| 3| 3| 5| 6| 5| 8| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |    1                                                                     |      1  1.0|
      Parasite Metazoan                    |          X        X                                      X               |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                                       3                  |      1  3.0|
      Parasite Metazoan                    |          X                          X     X                              |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         2     1                                          |      7  1.4|
      Basophilic Focus                     | X  X  X  X  X     X  X  X  X  X  X  X     X  X     X  X  X  X        X  X|     43     |
      Clear Cell Focus                     |             X        X     X        X              X  X              X  X|     16     |
      Degeneration, Fatty                  |                2              3                 3                        |      5  2.6|
      Hepatodiaphragmatic Nodule           |    X  X                 X  X                                   X         |      7     |
      Mixed Cell Focus                     |                                        X  X  X           X              X|      6     |
      Necrosis                             |                                           1                              |      1  1.0|
      Bile Duct, Hyperplasia               | 2                       1           2           2              2  2      |     10  1.7|
      Centrilobular, Necrosis              |                                                             1  2         |      3  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                         +                        |   6        |
      Fat, Necrosis                        |       2                                         2                        |      6  2.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1        1        3           2  1     4     2                          2|     14  1.7|
      Basophilic Focus                     |                         X                                                |      1     |
      Hyperplasia                          |                                                          2               |      2  2.0|
      Lipomatosis                          |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                        2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                               +           +           +                  |   4        |
      Hyperplasia, Squamous                |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 9| 8| 5| 2| 3| 0| 3| 3| 3| 2| 8| 0| 3| 3|            |
                                           | 4| 5| 4| 5| 5| 2| 9| 4| 4| 4| 3| 1| 1| 7| 1| 3| 7| 3| 3| 5| 6| 5| 8| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       |    1  1  3  2     2     1     1  1  1  1  1  1  1  2     1  1        1  2|     38  1.3|
      Atrium, Thrombosis                   |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2                                                               |      1  2.0|
      Hyperplasia                          | 1  2                 1  2     2     2  1  1  2           2        2     2|     22  1.7|
      Hypertrophy                          |    1                    1                       2        2               |     10  1.7|
      Vacuolization Cytoplasmic            |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2  2  2           2                          3                        |     11  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 4                                                                        |      1  4.0|
      Hyperplasia                          |                      2                                                   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |                                     3     3     2              2         |      5  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 2                                                                        |      1  2.0|
      C-Cell, Hyperplasia                  | 3  2  1  1  2  1  1  1  1  1        1  3  2  1  1  1              1     1|     38  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                          4               |      1  4.0|
      Inflammation, Chronic Active         |                   2                                                      |      4  3.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                               2        4                       3         |      6  2.5|
      Inflammation, Granulomatous          |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cervix, Hypertrophy                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                               +                             +     +      |   4        |
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 9| 8| 5| 2| 3| 0| 3| 3| 3| 2| 8| 0| 3| 3|            |
                                           | 4| 5| 4| 5| 5| 2| 9| 4| 4| 4| 3| 1| 1| 7| 1| 3| 7| 3| 3| 5| 6| 5| 8| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Cell                             |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  M  M  M  +  +  M  +  +  M  +|  34        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |    2                                      2                              |      4  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                   1                                         4            |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |    3                                            4                        |      5  3.2|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Chronic                  |          3                                                               |      1  3.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    2                       1           1     1  1     1  1  1        2  1|     22  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                        3                                 |      2  2.5|
      Thrombosis                           |                                                 2                        |      1  2.0|
      Olfactory Epithelium, Atrophy        |    1                                                                     |      1  1.0|
      Olfactory Epithelium, Metaplasia     |    1                                                                     |      1  1.0|
      Turbinate, Fibrosis, Focal           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 9| 8| 5| 2| 3| 0| 3| 3| 3| 2| 8| 0| 3| 3|            |
                                           | 4| 5| 4| 5| 5| 2| 9| 4| 4| 4| 3| 1| 1| 7| 1| 3| 7| 3| 3| 5| 6| 5| 8| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                             +            |   1        |
      Degeneration                         |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                            3                                             |      1  3.0|
      Nephropathy                          | 2  2  2  1  2  2  2  2  2  2  4  2  1  1  2  1  1  2  2  3  3  1  2  2  2|     48  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 5| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 6| 5| 7| 7| 7| 7| 6| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 9| 3| 8| 3| 6| 4| 9| 9| 3| 7| 3| 8| 2| 1| 9| 3| 3| 3| 3| 5| 0| 9| 5|             
                                           | 3| 4| 7| 5| 5| 5| 7| 6| 3| 1| 4| 0| 5| 8| 1| 8| 7| 3| 4| 4| 5| 1| 1| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                       X        X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X     X  X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                       X           X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3              2                                   1                     |             
      Basophilic Focus                     | X  X  X  X     X  X  X  X  X  X     X  X  X  X     X  X  X  X  X  X     X|             
      Clear Cell Focus                     |    X                             X                 X     X  X            |             
      Degeneration, Fatty                  |                                                                2         |             
      Eosinophilic Focus                   |    X                                                                     |             
      Hepatodiaphragmatic Nodule           |          X                                         X        X            |             
      Mixed Cell Focus                     |       X                       X        X           X                     |             
      Bile Duct, Hyperplasia               | 1     2     1              1        2     2        1                 2   |             
      Centrilobular, Necrosis              |             2     1        2              1                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +                       +  +                                 |             
      Fat, Necrosis                        |    2        2                       3  2                                 |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |          +                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2           3        2                 2  1  1  1        2           2  1|             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Lipomatosis                          |                                        3                                 |             
      Metaplasia, Hepatocyte               |                   2                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                     1                                    |             
      Necrosis                             |             1              3           1                                 |             
      Ulcer                                |                                                                3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                            2                                             |             
                                            __________________________________________________________________________|             
   Tongue                                  |                      +                 +           +                     |             
      Hyperplasia, Squamous                |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 5| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 6| 5| 7| 7| 7| 7| 6| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 9| 3| 8| 3| 6| 4| 9| 9| 3| 7| 3| 8| 2| 1| 9| 3| 3| 3| 3| 5| 0| 9| 5|             
                                           | 3| 4| 7| 5| 5| 5| 7| 6| 3| 1| 4| 0| 5| 8| 1| 8| 7| 3| 4| 4| 5| 1| 1| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     2  2           1  1  1     2     2     1  1  2     1     1     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2     2     2     1                                   2  2        1   |             
      Hypertrophy                          |                2                    2                       3            |             
      Necrosis                             |                            2                                             |             
      Vacuolization Cytoplasmic            |                2  1           2     1           2     2                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        1  2                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           | 1           2                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     2  1     2        1     2  1     1  1  1  2     1  1     2  1     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                    2     2                                          |             
      Inflammation, Chronic Active         | 2        2                                            2     3            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Granulomatous          |                      3                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +                             +      |             
      Iliac, Ectasia                       |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  M  M  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  M  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            2              3  2                           |             
      Hematopoietic Cell Proliferation     |                                                 2                 3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 5| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 6| 5| 7| 7| 7| 7| 6| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 9| 3| 8| 3| 6| 4| 9| 9| 3| 7| 3| 8| 2| 1| 9| 3| 3| 3| 3| 5| 0| 9| 5|             
                                           | 3| 4| 7| 5| 5| 5| 7| 6| 3| 1| 4| 0| 5| 8| 1| 8| 7| 3| 4| 4| 5| 1| 1| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                         3                       3                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         3              3                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                            4        4                                2   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1        1     3                          1        1  1  2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                            2                                             |             
      Olfactory Epithelium, Atrophy        |       1     2  1  3     1  1  1     1  3  1        1  2  1  2  2  1  1  2|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Basal Cell                      |    1  1                 2        1     1     1           1        1      |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic Active                  |                                        1  1                              |             
      Olfactory Epithelium, Metaplasia     |       1     1  1  1     1     1     1  1  1        1     1     1  1  1  1|             
      Olfactory Epithelium, Necrosis       |             2     3     1              3                       3  2      |             
      Turbinate, Fibrosis, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                             +                              |             
      Cataract                             |             2                                                            |             
      Retina, Atrophy                      |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  2  2  2  1  3  1  2  2  2  2  1  2  1  2  1  1  2  3  3  2  3     1  2|             
      Renal Tubule, Hyperplasia            |          2                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 9| 3| 0| 0| 3| 3| 3|            |
                                           | 4| 0| 4| 5| 4| 1| 5| 4| 3| 5| 3| 5| 9| 4| 4| 5| 4| 4| 0| 5| 8| 4| 4| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |    X                                                        X  X     X   |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X        X        X                 X                           |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X                             X           X        X              X|      8     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                    2  1                  |      5  1.8|
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X|     45     |
      Clear Cell Focus                     |          X        X  X  X  X  X                             X     X     X|     14     |
      Degeneration, Fatty                  |                                     2                          2         |      3  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |          X              X  X     X                    X        X         |      9     |
      Mixed Cell Focus                     |                X                                         X               |      6     |
      Bile Duct, Hyperplasia               |                                     2                          1  1      |     11  1.5|
      Centrilobular, Necrosis              |                                                                1         |      5  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +           +        +                          +         |   8        |
      Fat, Necrosis                        |                2           1        2                                    |      7  2.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                          +               |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       1              2  4        1        1        2     2               |     17  1.8|
      Basophilic Focus                     |                                     X                                    |      1     |
      Hyperplasia                          |                      3                                                   |      1  3.0|
      Lipomatosis                          |                         4                                                |      2  3.5|
      Metaplasia, Hepatocyte               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                   2      |      1  2.0|
      Basophilic Focus                     |                                                                   X      |      1     |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      3  1.7|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |             2              1  1                                   1      |      4  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 9| 3| 0| 0| 3| 3| 3|            |
                                           | 4| 0| 4| 5| 4| 1| 5| 4| 3| 5| 3| 5| 9| 4| 4| 5| 4| 4| 0| 5| 8| 4| 4| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                         +        +                                       |   5        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1     2  2        1  2  2     2  1  1     2  2  2  1  1        1  1     2|     31  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1     2        2        2  1  1  2     1        1  2  2  2        2  2   |     22  1.7|
      Hypertrophy                          |                      2        1                    2              2      |      7  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |          2              2     1        2                                 |     10  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2                    2  1                                      2      |      7  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      3        3                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |                                                                         3|      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1  1  1  1     1  2  1  1  2     1  1  2     2  1  2     2     1  2     1|     35  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                                  3                                       |      4  2.0|
      Inflammation, Chronic Active         |                   3                       1                              |      6  2.2|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                            2                                             |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                                                      1   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 9| 3| 0| 0| 3| 3| 3|            |
                                           | 4| 0| 4| 5| 4| 1| 5| 4| 3| 5| 3| 5| 9| 4| 4| 5| 4| 4| 0| 5| 8| 4| 4| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Histiocytic             |                                  4                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                           +         |   4        |
      Iliac, Ectasia                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +  M  +  M  +  +  +  +  +  M  +  M  M  +  +  +  M  M  +  M  M  M  +|  30        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  M  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M|  37        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      3  2.3|
      Hematopoietic Cell Proliferation     | 2                                                     3                  |      4  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                      4                                                   |      4  3.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                            2                                             |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |       2  1        3  2  1  2  2        1     3     1  1     1  1  2  1   |     22  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |                                                                          |      1  2.0|
      Olfactory Epithelium, Atrophy        | 2  2  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1     1     1  1  1  1|     40  1.3|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Basal Cell                      |    1           1  1  1  1        1                 1     1     1         |     17  1.1|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic Active                  |                                                                          |      2  1.0|
      Olfactory Epithelium, Metaplasia     | 2  1  1     1  1  1     1  1  1  1  1  1  1  1  1        1     1  1  1  1|     35  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 9| 3| 0| 0| 3| 3| 3|            |
                                           | 4| 0| 4| 5| 4| 1| 5| 4| 3| 5| 3| 5| 9| 4| 4| 5| 4| 4| 0| 5| 8| 4| 4| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Necrosis       |    1                                1                                    |      8  2.0|
      Turbinate, Fibrosis, Focal           |             1                                   1        1               |      3  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   3        |
      Cataract                             |    2                                                                     |      2  2.0|
      Retina, Atrophy                      |    3                                                                     |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 1  1  1  2  2  1  3  3  2  3  3  3  2  3  2  2  3  3  2  1  2  1  3  1  1|     49  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia |                                                             3            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 6| 5| 7| 4| 7| 7| 6| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 8| 2| 3| 2| 2| 3| 3| 4| 7| 5| 3| 6| 2| 3| 0| 3| 3| 1| 4|             
                                           | 7| 4| 5| 4| 2| 5| 9| 4| 4| 0| 4| 5| 4| 9| 3| 3| 4| 3| 1| 3| 9| 4| 4| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                  3                                       |             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                 2                                   1         |             
      Basophilic Focus                     | X  X  X  X  X  X     X  X     X     X  X  X  X  X  X  X  X  X  X  X  X   |             
      Clear Cell Focus                     |          X  X  X                                               X         |             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration, Fatty                  |                   2                                   2                  |             
      Eosinophilic Focus                   |                X              X                                          |             
      Hepatodiaphragmatic Nodule           | X     X        X              X                                X     X   |             
      Mixed Cell Focus                     |    X     X              X                 X  X                       X   |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |    1              2        2     2  2  1                       1  2      |             
      Centrilobular, Necrosis              |                   1           1  1     1                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +  +  +  +     +                             +            |             
      Inflammation, Chronic Active         |                                                                          |             
      Fat, Necrosis                        | 2              2  2  2        2                             3            |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                   +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            1        1  2  2                              |             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2                                                |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                           4                              |             
      Mineralization                       |                               1                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               3        1                                 |             
                                            __________________________________________________________________________|             
   Tongue                                  |          +                          +           +     +           +      |             
      Hyperplasia, Squamous                |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 6| 5| 7| 4| 7| 7| 6| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 8| 2| 3| 2| 2| 3| 3| 4| 7| 5| 3| 6| 2| 3| 0| 3| 3| 1| 4|             
                                           | 7| 4| 5| 4| 2| 5| 9| 4| 4| 0| 4| 5| 4| 9| 3| 3| 4| 3| 1| 3| 9| 4| 4| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  2  1  1     1  1                 2  1  2  1  2  1  1  2  2  2  1|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Schwann Cell, Hyperplasia            |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  1                             2  1           3  2     1  3      |             
      Hypertrophy                          |             3              2     1                             1         |             
      Vacuolization Cytoplasmic            |                                  2  2  2        1                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2  2  2                    2                       1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    3              2                 1  3                       2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  2  1  2  1     1  2  1     1        2  2  1  2     1     1     1  1  3|             
      Follicular Cell, Hyperplasia         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                 3  2                           |             
      Inflammation, Chronic Active         |    2                                                                 2  2|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       2                                                                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                                                     +      |             
      Iliac, Ectasia                       |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  M  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 6| 5| 7| 4| 7| 7| 6| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 8| 2| 3| 2| 2| 3| 3| 4| 7| 5| 3| 6| 2| 3| 0| 3| 3| 1| 4|             
                                           | 7| 4| 5| 4| 2| 5| 9| 4| 4| 0| 4| 5| 4| 9| 3| 3| 4| 3| 1| 3| 9| 4| 4| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |          2                                                               |             
      Fibrosis                             |                3                 2              1                        |             
      Hematopoietic Cell Proliferation     |             4                 4                                         3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |          X                                                               |             
      Inflammation, Chronic Active         |                                        1                 3               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |                                                       X                  |             
      Hyperostosis                         |             2                                                            |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      2   |             
      Alveolar Epithelium, Hyperplasia     | 2  1  1        2                    2     1  1  1  1  1  2     1     2   |             
      Artery, Mediastinum, Inflammation    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                   1                                                      |             
      Nasolacrimal Duct, Hyperplasia,      |                                                                          |             
          Squamous                         |                                                                          |             
      Olfactory Epithelium, Atrophy        | 2  4  4  4  3  3  3  3  3  4  3  3  3  4  3  2  4  2  3  3  2  3  3  3  3|             
      Olfactory Epithelium, Fibrosis       | 2  2  2  1  2  3  3  3  4  2  2  3  3  2  2  1  3     2  3  2  3  2  1  2|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Basal Cell                      | 2  2  2  2  1  3  3  3  3  2  3  3  3  2  2  2  3  1  3  3  3  3  1  1  2|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Adenomatous                     |    2  2  3  2              3           2  3     1  1  1  2  1  1  2     3|             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic Active                  |    2     2  2              2           1        2  2  2  2  1  1  4  2  2|             
      Olfactory Epithelium, Metaplasia     | 2  3  3  4  3  3  3  2  3  3  3  3  3  3  3  2  4  2  2  3  2  3  3  3  3|             
      Olfactory Epithelium, Necrosis       |    1                                         2  1     1  1     2         |             
      Olfactory Epithelium, Glands, Atypia |                                                                          |             
          Cellular                         |                   1                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 6| 5| 7| 4| 7| 7| 6| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 8| 2| 3| 2| 2| 3| 3| 4| 7| 5| 3| 6| 2| 3| 0| 3| 3| 1| 4|             
                                           | 7| 4| 5| 4| 2| 5| 9| 4| 4| 0| 4| 5| 4| 9| 3| 3| 4| 3| 1| 3| 9| 4| 4| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Cataract                             |                      3                                                   |             
      Retina, Atrophy                      |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Oncocytic               |                                                       2                  |             
      Infarct                              |                                     3                                    |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 2  3  2  3     2  1  2  3  2  2  2  2  1  3  2  2  2  3  2  2  2  1  2  3|             
      Artery, Inflammation                 |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Hyperplasia            |                         1                                               1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 5| 7| 7| 6| 4| 7| 5| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 0| 3| 7| 9| 3| 3| 1| 3| 3| 7| 3| 6| 3| 3| 3| 6| 1| 1| 6| 0| 3| 3| 7|            |
                                           | 5| 9| 5| 4| 1| 1| 3| 4| 7| 3| 5| 6| 5| 7| 3| 4| 5| 6| 3| 6| 0| 5| 4| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                            X           X                                 |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  3.0|
      Parasite Metazoan                    |                      X                                                   |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    | X                                      X              X                  |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                      1        3                          2     3  2      |      8  1.9|
      Basophilic Focus                     |    X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     44     |
      Clear Cell Focus                     |                      X                                               X   |      6     |
      Degeneration, Cystic                 |             1                                   1                        |      2  1.0|
      Degeneration, Fatty                  |                                                                         3|      3  2.3|
      Eosinophilic Focus                   |                                                                          |      2     |
      Hepatodiaphragmatic Nodule           |                         X        X                                   X   |      9     |
      Mixed Cell Focus                     |                         X              X                 X               |      9     |
      Necrosis                             |                                                       2        3         |      2  2.5|
      Bile Duct, Hyperplasia               |    2        1     2  1        1     2                 2           2      |     16  1.6|
      Centrilobular, Necrosis              | 1  2              1                 1                                    |      8  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +           +  +                                      +   |  11        |
      Inflammation, Chronic Active         |                               4                                          |      1  4.0|
      Fat, Necrosis                        |                2           2                                         2   |      9  2.1|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   1     1     2     1        3                           |      9  1.6|
      Basophilic Focus                     |                      X                                            X  X   |      3     |
      Hyperplasia                          |          1                                                     2         |      2  1.5|
      Artery, Inflammation                 |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                     2                 2                  |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                         2  3                                             |      3  3.0|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                                                                         2|      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 5| 7| 7| 6| 4| 7| 5| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 0| 3| 7| 9| 3| 3| 1| 3| 3| 7| 3| 6| 3| 3| 3| 6| 1| 1| 6| 0| 3| 3| 7|            |
                                           | 5| 9| 5| 4| 1| 1| 3| 4| 7| 3| 5| 6| 5| 7| 3| 4| 5| 6| 3| 6| 0| 5| 4| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                      2                                                   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |    +  +     +                             +                 +  +  +      |  12        |
      Hyperplasia, Squamous                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1  2  2  1  2  2        2     1  2  2  1  2  2  1  2  2  2  2  1  1|     41  1.5|
      Artery, Inflammation, Chronic        |                               3                                          |      1  3.0|
      Schwann Cell, Hyperplasia            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2  2        2  2        1           2     1        2  2  2     1  2|     20  1.8|
      Hypertrophy                          |          2     1        2                          1  2  2               |     10  1.7|
      Vacuolization Cytoplasmic            |                         2           2              2           1         |      8  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1                       2        1     3                 2      |     10  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           | 3              2  2                             2                    2   |     10  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                      2        1  1  1  3     1  2     1  1              2|     28  1.5|
      Follicular Cell, Hyperplasia         |                      3                                                   |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  46        |
      Hyperplasia                          |                      3                                                   |      4  2.3|
      Inflammation, Chronic Active         |                                     2                                    |      4  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                          2  3            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 5| 7| 7| 6| 4| 7| 5| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 0| 3| 7| 9| 3| 3| 1| 3| 3| 7| 3| 6| 3| 3| 3| 6| 1| 1| 6| 0| 3| 3| 7|            |
                                           | 5| 9| 5| 4| 1| 1| 3| 4| 7| 3| 5| 6| 5| 7| 3| 4| 5| 6| 3| 6| 0| 5| 4| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                   +                             +      |   5        |
      Iliac, Ectasia                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  M  M  +|  36        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      1     |
      Angiectasis                          |                                                                          |      1  2.0|
      Fibrosis                             |    2                                                           3         |      5  2.2|
      Hematopoietic Cell Proliferation     |                            2  2                             4            |      6  3.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Chronic Active         |                                           2                              |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fracture                             |                                                                          |      1     |
      Hyperostosis                         |                            2              2                              |      3  2.0|
      Hyperplasia                          |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                      2   |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |       2  1  1     3  1  1     1  1  1  1  1  2  1  1  1  1  1  1  1  2  1|     34  1.3|
      Artery, Mediastinum, Inflammation    |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |    2                                2                                    |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 5| 7| 7| 6| 4| 7| 5| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 0| 3| 7| 9| 3| 3| 1| 3| 3| 7| 3| 6| 3| 3| 3| 6| 1| 1| 6| 0| 3| 3| 7|            |
                                           | 5| 9| 5| 4| 1| 1| 3| 4| 7| 3| 5| 6| 5| 7| 3| 4| 5| 6| 3| 6| 0| 5| 4| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Hyperplasia,      |                                                                          |            |
          Squamous                         |                                                                3         |      1  3.0|
      Olfactory Epithelium, Atrophy        | 2  3  2  3  3  3  2  2  3  2  3  3  3  3  3  2  3  3  3  3  3  4  3  3  3|     50  2.9|
      Olfactory Epithelium, Fibrosis       | 2  2  2  2  3  2  2  3  1  1  2  2  2  1  2  2  2  1  2  3  3  3  2  2  2|     49  2.2|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Basal Cell                      | 2  2  2  3  3  3  2  3  3  2  3  2  2     2  2  3  1  2  3  3  3  2  2  2|     49  2.3|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Adenomatous                     |    2  3                       2     2  3  1           1  3     3  2  2  1|     27  2.0|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic Active                  |    1  2  1     2     2  2     1     3  2  3  1  1  4  2  2     2  3  3  3|     33  2.0|
      Olfactory Epithelium, Metaplasia     | 2  3  2  3  2  3  2  2  3  2  2  2  3  3  3  2  2  3  3  3  3  4  3  3  3|     50  2.7|
      Olfactory Epithelium, Necrosis       | 1  1                 1  1                                   2           2|     12  1.3|
      Olfactory Epithelium, Glands, Atypia |                                                                          |            |
          Cellular                         |                               4                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   2        |
      Cataract                             |    3                                                                     |      2  3.0|
      Retina, Atrophy                      |    4                                                                     |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Oncocytic               |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  3.0|
      Mineralization                       |                2                                                         |      1  2.0|
      Nephropathy                          | 1  2  2  3  1  3  1  3  3  1  3  1  2  3  3  3  3  2  2  2  1  3  3  2  2|     49  2.2|
      Artery, Inflammation                 |                               3                                          |      1  3.0|
      Pelvis, Inflammation, Acute          |                3                                                         |      1  3.0|
      Renal Tubule, Hyperplasia            |                                  1                       3               |      4  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia | 3                                                                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 6| 5| 7| 7| 6| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 7| 3| 0| 2| 5| 1| 3| 1| 0| 3| 7| 3| 9| 9| 1| 8| 3| 3| 3| 3| 3| 0| 8| 1| 3|             
                                           | 5| 4| 4| 2| 7| 6| 7| 6| 0| 3| 6| 7| 3| 5| 3| 9| 3| 3| 4| 6| 3| 2| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                          X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                4                                                         |             
      Parasite Metazoan                    |                            X                 X     X                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       X  X                 X  X  X     X  X        X        X  X         |             
      Clear Cell Focus                     |    X                       X           X              X  X               |             
      Degeneration, Cystic                 |          4           3                             2           2  2      |             
      Degeneration, Fatty                  |                                        2                             2   |             
      Hepatodiaphragmatic Nodule           |                               X                                          |             
      Regeneration                         |                               4                                          |             
      Bile Duct, Hyperplasia               |       3  3  3  3  1  2              3  1     2  2     2     2  3  3  2  1|             
      Centrilobular, Necrosis              |             2  2     1                                         2  2      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +  +     +  +                       +                          +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        | 2     2  2     3  2                       2                          2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1     2     2  2     1        1     1  2  1  2  1  2        2        3  2|             
      Basophilic Focus                     |                      X                                                   |             
      Hyperplasia                          |          3           2           1                    2                 1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                   2                                                      |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                         1                                      1         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       1                                            1                     |             
      Necrosis                             |       1        3                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2     1  2  2  2  2  2  3  2  2     2  2  2  2  2  1  1  2  2  1  2  3|             
      Atrium, Thrombosis                   |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 6| 5| 7| 7| 6| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 7| 3| 0| 2| 5| 1| 3| 1| 0| 3| 7| 3| 9| 9| 1| 8| 3| 3| 3| 3| 3| 0| 8| 1| 3|             
                                           | 5| 4| 4| 2| 7| 6| 7| 6| 0| 3| 6| 7| 3| 5| 3| 9| 3| 3| 4| 6| 3| 2| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  2           2  1     2     2        2           2  1  1        2  2|             
      Hypertrophy                          |                                                 3                        |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     2  2              2     2  2  1     1  2  2  1     2  3  2  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    2                    2  2                                            2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1     1  1     2  1     2  1  2  1  1  2  1     2  1     1     1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                +                                                         |             
      Hyperplasia                          |                3                                                         |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                         2|             
                                            __________________________________________________________________________|             
   Penis                                   |       +                                                                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                          1                                   2         |             
      Inflammation, Chronic Active         | 3                 1                    2                 2  3            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                   1        2  2                        |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Mineralization                       |    2                                                                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Artery, Inflammation, Chronic Active |                                  2     2                                 |             
      Interstitial Cell, Hyperplasia       | 2           1     2                                1                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +              +           +                             +      |             
      Renal, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 6| 5| 7| 7| 6| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 7| 3| 0| 2| 5| 1| 3| 1| 0| 3| 7| 3| 9| 9| 1| 8| 3| 3| 3| 3| 3| 0| 8| 1| 3|             
                                           | 5| 4| 4| 2| 7| 6| 7| 6| 0| 3| 6| 7| 3| 5| 3| 9| 3| 3| 4| 6| 3| 2| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                 X                        |             
      Fibrosis                             |       2     2  2           3  3                 3     2        2  2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  M  +  M  M  M  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +|             
      Galactocele                          |                   2              2                                       |             
      Inflammation, Chronic                |                                                             3            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular                |             3                                                            |             
      Metaplasia, Cartilagenous            |                                  2                                       |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1                 2     2  1                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                3                                                         |             
      Thrombosis                           |             3        1                       1                 3  4      |             
      Olfactory Epithelium, Atrophy        |    2                                                                     |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Adenomatous                     |    2                                      2                              |             
      Olfactory Epithelium, Metaplasia     |    2     1                                                        2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 6| 5| 7| 7| 6| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 7| 3| 0| 2| 5| 1| 3| 1| 0| 3| 7| 3| 9| 9| 1| 8| 3| 3| 3| 3| 3| 0| 8| 1| 3|             
                                           | 5| 4| 4| 2| 7| 6| 7| 6| 0| 3| 6| 7| 3| 5| 3| 9| 3| 3| 4| 6| 3| 2| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Mineralization                       |    2                                                                     |             
      Nephropathy                          | 2  3  3  2  3  3  2  3  2  4  1  3  3  3  4  2  3  3  3  3  4  3  2  4  3|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular                |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 5| 4| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 8| 3| 3| 7| 3| 9| 3| 4| 6| 9| 3| 5| 3| 2| 6| 6| 4| 1| 4| 4|            |
                                           | 3| 3| 3| 6| 3| 0| 3| 4| 1| 3| 5| 3| 1| 9| 5| 3| 8| 3| 5| 9| 9| 6| 6| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                             2            |      1  2.0|
      Parasite Metazoan                    | X           X  X                                   X                     |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Necrosis                             |                                                                          |      1  4.0|
      Parasite Metazoan                    | X              X  X              X              X  X              X      |     10     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       2     1                                                            |      2  1.5|
      Basophilic Focus                     | X     X     X                       X        X  X                        |     16     |
      Clear Cell Focus                     |             X                    X                 X                     |      8     |
      Degeneration, Cystic                 | 2     4     2     3        2              2     2           2            |     13  2.5|
      Degeneration, Fatty                  |                                                                         3|      3  2.3|
      Hepatodiaphragmatic Nodule           |                                           X                              |      2     |
      Regeneration                         |                                                             4            |      2  4.0|
      Bile Duct, Hyperplasia               | 2     3  3     2     3  2  2  2  1  2     3  1  2  2  1     3  3  3  2  2|     36  2.2|
      Centrilobular, Necrosis              |       1  2     1     2     1                                2     2  2   |     13  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +        +     +  +  +                                +        +  +   |  16        |
      Inflammation, Chronic Active         |                                                                      4   |      1  4.0|
      Fat, Hemorrhage                      |                                                                      4   |      1  4.0|
      Fat, Necrosis                        | 3  2        2     2  2  2                                2        2      |     15  2.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1  1  3  1                 2  1  2           3        1  1     3  2      |     27  1.7|
      Basophilic Focus                     |                            X                                             |      2     |
      Hyperplasia                          |                                                    3                    3|      7  2.1|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                           2                              |      2  2.0|
      Mineralization                       |                                     1                                    |      1  1.0|
      Necrosis                             |                                                                          |      2  1.0|
      Ulcer                                |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
      Mineralization                       |                                                                1  2     1|      5  1.2|
      Necrosis                             |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 5| 4| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 8| 3| 3| 7| 3| 9| 3| 4| 6| 9| 3| 5| 3| 2| 6| 6| 4| 1| 4| 4|            |
                                           | 3| 3| 3| 6| 3| 0| 3| 4| 1| 3| 5| 3| 1| 9| 5| 3| 8| 3| 5| 9| 9| 6| 6| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  1  2     2  2  1     1     2  1  2  1     3  1  1     1  2  2  2|     43  1.8|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2              2              1  2           2  2     1           2  2|     23  1.8|
      Hypertrophy                          |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2              2     2              3                       1  2  2  1   |     23  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         3                             3                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |       2           1                       1        3                     |      5  1.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |       2                             2                                3   |      7  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1  1  1  3  2     1  1     1              1  1        1  1  1  1  1     2|     34  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                3                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            2                                             |      4  1.8|
      Inflammation, Chronic Active         |                3              2        1        3                        |      9  2.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             3  2                                   2                     |      7  1.9|
      Inflammation, Chronic Active         |          3                                                               |      2  2.5|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 5| 4| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 8| 3| 3| 7| 3| 9| 3| 4| 6| 9| 3| 5| 3| 2| 6| 6| 4| 1| 4| 4|            |
                                           | 3| 3| 3| 6| 3| 0| 3| 4| 1| 3| 5| 3| 1| 9| 5| 3| 8| 3| 5| 9| 9| 6| 6| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                               2                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.0|
      Interstitial Cell, Hyperplasia       |    1                    1  2                    1           1           1|     10  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +           +        +              +                    +  +      |  12        |
      Renal, Hemorrhage                    |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ectasia                              |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                             X            |      2     |
      Fibrosis                             |       3        2  3        3                 2  3  3                    2|     17  2.5|
      Hematopoietic Cell Proliferation     |                                     2                 2                  |      2  2.0|
      Hemorrhage                           |                                           3                              |      1  3.0|
      Necrosis                             |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  M  M  M  +  M  +  +  +  M  +  +  M  M  M  M  +  M  +|  30        |
      Galactocele                          |                                                                   2     2|      4  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                           X                              |      1     |
      Inflammation, Chronic Active         |    2              3                                2                     |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 5| 4| 6| 7| 6| 7| 5| 5| 5| 6| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 8| 3| 3| 7| 3| 9| 3| 4| 6| 9| 3| 5| 3| 2| 6| 6| 4| 1| 4| 4|            |
                                           | 3| 3| 3| 6| 3| 0| 3| 4| 1| 3| 5| 3| 1| 9| 5| 3| 8| 3| 5| 9| 9| 6| 6| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                             1            |      1  1.0|
      Infiltration Cellular                |                                                                          |      1  3.0|
      Metaplasia, Cartilagenous            |                                                                          |      1  2.0|
      Thrombosis                           |                   2                                                      |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    1                                                                     |      5  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Thrombosis                           |                               2                             4  2  3  2   |     10  2.5|
      Olfactory Epithelium, Atrophy        |             1        2                                                   |      3  1.7|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Adenomatous                     |                                                                          |      2  2.0|
      Olfactory Epithelium, Metaplasia     | 2           1        2                                                   |      6  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                   2                       2        2                     |      3  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          | 3  2  4  2  4  2  4  3  2  2  3  3  2  2  4  3  3  4  2  2  3  2  3  2  3|     50  2.8|
      Renal Tubule, Hyperplasia            |       2                                            3                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 5| 6| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 8| 3| 1| 6| 0| 1| 3| 6| 0| 4| 0| 7| 3| 7| 2| 4| 3| 9| 6| 3|             
                                           | 8| 3| 0| 4| 3| 9| 3| 3| 5| 2| 8| 0| 3| 1| 4| 1| 0| 3| 7| 5| 5| 3| 7| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                          X           X           X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  I  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    2                                                                     |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                 X                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                      2  2     1               |             
      Basophilic Focus                     |    X     X  X              X     X     X           X        X     X      |             
      Clear Cell Focus                     |                                  X     X     X     X                     |             
      Degeneration, Cystic                 | 2           3  2     2  2  4        3        2           2  1        1   |             
      Degeneration, Fatty                  |                                           2                              |             
      Hepatodiaphragmatic Nodule           |                         X                                                |             
      Inflammation, Chronic                |                         1                                                |             
      Mixed Cell Focus                     |                                              X                           |             
      Necrosis                             |                                  1                                       |             
      Regeneration                         |                                     3                                    |             
      Bile Duct, Hyperplasia               | 3  3  3  1  1  3  3  3  1  2  2  1  3        2  2  1  1  3  1        1  2|             
      Centrilobular, Necrosis              | 2  2  2              3              1                       1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                       +  +                 +  +                 +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Fat, Necrosis                        |    2                       2  2                 2  3                 2   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                2     1        2  2  2              3     3  2  1  2  2  1|             
      Basophilic Focus                     |             X                                                            |             
      Hyperplasia                          |                                                                3         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Mineralization                       |                      2                                                   |             
      Necrosis                             |                   4                 4     2                          3   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   2                    2     2                           |             
      Necrosis                             |       3                                         3                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
      Developmental Malformation           |                                                                   X      |             
      Inflammation, Chronic Active         |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 5| 6| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 8| 3| 1| 6| 0| 1| 3| 6| 0| 4| 0| 7| 3| 7| 2| 4| 3| 9| 6| 3|             
                                           | 8| 3| 0| 4| 3| 9| 3| 3| 5| 2| 8| 0| 3| 1| 4| 1| 0| 3| 7| 5| 5| 3| 7| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  3  2  2  2  3  2  2  2     3  2  1  1  2     2  2  2  2  3  2  3  3|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                   2  2  1           2     2  1  2  2  1           2  2  2|             
      Hypertrophy                          |                                                                          |             
      Necrosis                             | 3                                                                        |             
      Vacuolization Cytoplasmic            |    2                                                  2                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2              3  2  2  2     1        2     2  2  3              3  2|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                 2        4                 1        2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                3         |             
      Pars Distalis, Hyperplasia           |                                        2                                 |             
      Pars Intermedia, Hyperplasia         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2  1           1     1     2  1  3  2     1     1        1  2  2     1|             
      Follicular Cell, Hyperplasia         |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Hyperplasia                          |                                     3  3                                 |             
                                            __________________________________________________________________________|             
   Penis                                   | +                                                                        |             
      Vein, Fibrosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                          3                                      2|             
      Inflammation, Chronic Active         |                            2     3           3                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        1  3                                               2         |             
      Inflammation, Chronic Active         |                                                       3                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 5| 6| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 8| 3| 1| 6| 0| 1| 3| 6| 0| 4| 0| 7| 3| 7| 2| 4| 3| 9| 6| 3|             
                                           | 8| 3| 0| 4| 3| 9| 3| 3| 5| 2| 8| 0| 3| 1| 4| 1| 0| 3| 7| 5| 5| 3| 7| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   4                                                      |             
      Hyperplasia                          |                                        3                                 |             
      Artery, Inflammation, Chronic Active |                                                                      2   |             
      Interstitial Cell, Hyperplasia       |                                     1                       1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +  +        +                    +              +         |             
      Iliac, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    |             1                                                  1         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  M  +  +  +  M  +  +  M  +  +  +  M  M  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |       X                                                                  |             
      Fibrosis                             | 3  2  2     2     2        2           2     2                       2   |             
      Hematopoietic Cell Proliferation     |                                                             4            |             
      Hemorrhage                           |                      3                                                   |             
      Metaplasia, Lipocyte                 |                                                                      2   |             
      Necrosis                             |       4                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  +  M  M  M  +  M  +  M  M  +  M  M  +  +  M  M  M  +  +  +|             
      Galactocele                          |                                                    2                 3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |             4                          3                                 |             
      Inflammation, Chronic Active         |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                   3                          3                       1   |             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 5| 6| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 8| 3| 1| 6| 0| 1| 3| 6| 0| 4| 0| 7| 3| 7| 2| 4| 3| 9| 6| 3|             
                                           | 8| 3| 0| 4| 3| 9| 3| 3| 5| 2| 8| 0| 3| 1| 4| 1| 0| 3| 7| 5| 5| 3| 7| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    12.8 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      3                                                   |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                      2                                                   |             
      Alveolar Epithelium, Hyperplasia     |          2  1           1              1     1     3  1  1           1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       4                                                                  |             
      Thrombosis                           | 3     2                                                                  |             
      Olfactory Epithelium, Atrophy        | 1                 1        2           1  2  2              1        3   |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic Active                  |                                           1  1                       1   |             
      Olfactory Epithelium, Metaplasia     | 1                 1                                         1        1   |             
      Olfactory Epithelium, Necrosis       | 1                 1        3           1  3  2                       3   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   2                          3                          3|             
      Infarct                              |                                                                          |             
      Nephropathy                          | 2  3  3  2  4  2  4  4  3  4  2  4  4  4  4  4  2  3  3  2  3  4  2  4  3|             
      Renal Tubule, Hyperplasia            |                                              2                 3     2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        4                                 |             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 7| 4| 5| 7| 5| 6| 6| 6| 6| 7| 3| 7| 7| 6| 7| 5| 7| 5| 5| 6| 6|            |
                             DAY ON TEST   | 5| 3| 4| 8| 3| 3| 4| 0| 5| 0| 6| 7| 0| 0| 5| 0| 3| 0| 3| 8| 3| 7| 9| 0| 5|            |
                                           | 0| 7| 1| 1| 3| 7| 1| 6| 6| 0| 5| 9| 9| 7| 7| 0| 3| 8| 0| 1| 3| 5| 7| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    | X                             X                             X            |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Mineralization                       |                                                                          |      1  2.0|
      Parasite Metazoan                    |       X                                                                  |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                               X              X     X        X            |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                 1                        |      5  1.6|
      Basophilic Focus                     | X  X     X           X  X     X  X           X                           |     17     |
      Clear Cell Focus                     |                                              X              X            |      6     |
      Degeneration, Cystic                 | 2  2     2                                   3        3        2  2      |     18  2.2|
      Degeneration, Fatty                  |       2           2                       3                              |      4  2.3|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                      2                                                   |      2  1.5|
      Regeneration                         |                         4                                            3   |      3  3.3|
      Bile Duct, Hyperplasia               |    1  3  1           3  2  1  2  2  2  3     2     2  2  2  1  3  2  3  2|     40  2.0|
      Centrilobular, Necrosis              |       1                 2           1              1  1        2  1      |     13  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +  +        +  +        +  +        +|  13        |
      Inflammation, Chronic Active         |                                                                         4|      1  4.0|
      Fat, Necrosis                        |                                     3  2        2  3        2  2        4|     13  2.4|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2  2  2  2  2     2  3  1        1  2        1        3  2  1  1         |     27  1.9|
      Basophilic Focus                     |                            X                                             |      2     |
      Hyperplasia                          |    2                                            2                        |      3  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |          2                                                               |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                           2                              |      5  3.0|
      Ulcer                                |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 7| 4| 5| 7| 5| 6| 6| 6| 6| 7| 3| 7| 7| 6| 7| 5| 7| 5| 5| 6| 6|            |
                             DAY ON TEST   | 5| 3| 4| 8| 3| 3| 4| 0| 5| 0| 6| 7| 0| 0| 5| 0| 3| 0| 3| 8| 3| 7| 9| 0| 5|            |
                                           | 0| 7| 1| 1| 3| 7| 1| 6| 6| 0| 5| 9| 9| 7| 7| 0| 3| 8| 0| 1| 3| 5| 7| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |       2                                                     1            |      5  1.8|
      Necrosis                             |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +                                                               |   2        |
      Developmental Malformation           |                                                                          |      1     |
      Inflammation, Chronic Active         |          4                                                               |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  1  1  2  1  2  2  1  3  1  2  2  2  2  2  1  2  2     2  2  2  2  1|     46  2.0|
      Atrium, Thrombosis                   |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                               3                                          |      1  3.0|
      Hyperplasia                          | 1  2        2  1  2  2     2           2        2           2  2  2     2|     25  1.8|
      Hypertrophy                          |                                                 2                        |      1  2.0|
      Necrosis                             |                         2                                                |      2  2.5|
      Vacuolization Cytoplasmic            | 2                 3                                                      |      4  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                 2        3     2                 3           2  2      |     19  2.2|
      Necrosis                             |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2                                                               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Hyperplasia                          |             3        2                 2     2                          2|     10  2.2|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |    2                 3  2                                                |      4  2.3|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1           1           2           1  1  1     1  2                 1  3|     24  1.5|
      Follicular Cell, Hyperplasia         |                            2                                             |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |          3        3                                3                     |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 7| 4| 5| 7| 5| 6| 6| 6| 6| 7| 3| 7| 7| 6| 7| 5| 7| 5| 5| 6| 6|            |
                             DAY ON TEST   | 5| 3| 4| 8| 3| 3| 4| 0| 5| 0| 6| 7| 0| 0| 5| 0| 3| 0| 3| 8| 3| 7| 9| 0| 5|            |
                                           | 0| 7| 1| 1| 3| 7| 1| 6| 6| 0| 5| 9| 9| 7| 7| 0| 3| 8| 0| 1| 3| 5| 7| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                      +                 +                                 |   3        |
      Vein, Fibrosis                       |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      3  2.3|
      Inflammation, Chronic Active         |                   2           2     3                                    |      6  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                             2     1                                    |      7  1.9|
      Inflammation, Chronic Active         |             3                          2                          4      |      4  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       3           3                       4                              |      4  3.5|
      Hyperplasia                          |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active | 2                                                                        |      2  2.0|
      Interstitial Cell, Hyperplasia       |                            1                                   1         |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +        +  +                 +     +           +     +  +  +   |  18        |
      Iliac, Ectasia                       |          3                                                               |      1  3.0|
      Renal, Hemorrhage                    |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  M  M  +  M  +  +  +  +  +  M  +  M  +  +  +  M  +  M  +  M  +  +  M|  31        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|  45        |
      Infiltration Cellular, Plasma Cell   |          3                                                               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      1     |
      Fibrosis                             |             2     3  3  3              3     2  2  2  3  2               |     19  2.3|
      Hematopoietic Cell Proliferation     |    3                                                                     |      2  3.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Metaplasia, Lipocyte                 |                                                                          |      1  2.0|
      Necrosis                             |                                                                2         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  M  M  M  +  +  M  +  M  +  +  M  M  +  +  M  +  +  M  M  M  +|  23        |
      Galactocele                          |                                        3                                 |      3  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 7| 4| 5| 7| 5| 6| 6| 6| 6| 7| 3| 7| 7| 6| 7| 5| 7| 5| 5| 6| 6|            |
                             DAY ON TEST   | 5| 3| 4| 8| 3| 3| 4| 0| 5| 0| 6| 7| 0| 0| 5| 0| 3| 0| 3| 8| 3| 7| 9| 0| 5|            |
                                           | 0| 7| 1| 1| 3| 7| 1| 6| 6| 0| 5| 9| 9| 7| 7| 0| 3| 8| 0| 1| 3| 5| 7| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |    4                                2                                   2|      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |       3                                                                  |      4  2.5|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              2                           |      1  2.0|
      Necrosis                             |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                      1                                                   |      2  2.0|
      Metaplasia, Osseous                  |                                  1                                       |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |          1                                   2  2  2        1     2     1|     16  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Thrombosis                           |       2              3  4                          3  2           3  1   |      9  2.6|
      Olfactory Epithelium, Atrophy        |             3                             3                    1        1|     12  1.8|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic Active                  |             1                             1                              |      5  1.0|
      Olfactory Epithelium, Metaplasia     |                                           1                              |      5  1.0|
      Olfactory Epithelium, Necrosis       |             3                             3              1     1         |     11  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                  |   1        |
      Retina, Atrophy                      |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 7| 4| 5| 7| 5| 6| 6| 6| 6| 7| 3| 7| 7| 6| 7| 5| 7| 5| 5| 6| 6|            |
                             DAY ON TEST   | 5| 3| 4| 8| 3| 3| 4| 0| 5| 0| 6| 7| 0| 0| 5| 0| 3| 0| 3| 8| 3| 7| 9| 0| 5|            |
                                           | 0| 7| 1| 1| 3| 7| 1| 6| 6| 0| 5| 9| 9| 7| 7| 0| 3| 8| 0| 1| 3| 5| 7| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    12.8 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Infarct                              |       3                                                        2         |      2  2.5|
      Nephropathy                          | 4  2  2  2  4  2  3  3  2  3  2  3  2  4  4  3  4  2  3  2  4  3  3  2  4|     50  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |          3  2                                                            |      2  2.5|
      Transitional Epithelium, Hyperplasia |          4                                                               |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 5| 5| 6| 5| 5| 7| 7| 5| 5| 5| 6| 7| 5| 5| 7| 5| 6| 5| 7| 5| 6| 4|             
                             DAY ON TEST   | 2| 3| 6| 2| 6| 4| 9| 3| 3| 0| 6| 3| 6| 2| 3| 6| 2| 2| 4| 6| 6| 0| 4| 0| 6|             
                                           | 0| 7| 8| 3| 9| 2| 0| 4| 3| 5| 5| 4| 9| 2| 3| 7| 8| 1| 0| 5| 9| 2| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                           3                              |             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                    X           X     X        X                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2              1                                                         |             
      Basophilic Focus                     | X        X     X  X     X              X  X  X           X               |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 | 2              2        3  3  2        1  2        3     3           1   |             
      Degeneration, Fatty                  |                                                             2            |             
      Eosinophilic Focus                   |                            X        X                          X         |             
      Hepatodiaphragmatic Nodule           | X                                            X                       X   |             
      Mixed Cell Focus                     | X                                X                                       |             
      Necrosis                             |                                                                          |             
      Regeneration                         |                3              2                 3                        |             
      Thrombosis                           |                                                                2         |             
      Bile Duct, Hyperplasia               | 2  2     2  2  3  2  2  3  1  3        2        2  3        2  1  2  1  1|             
      Centrilobular, Necrosis              |    1        1  1     1                 1        3           1     1      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +  +     +        +              +     +        +  +        +  +   |             
      Artery, Mineralization               |                                                                          |             
      Fat, Necrosis                        | 3     2  2     2                       2     2           2        2  2   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             | +                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1           2  2  1  2  2  2  2           2  1  2     1     2  1  2     1|             
      Basophilic Focus                     |                                                    X                     |             
      Hyperplasia                          |                               2        2                 2           2   |             
      Artery, Inflammation                 |                            3                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                2         |             
      Ulcer                                |                                                          4  4            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                            3                                             |             
      Necrosis                             |          2        2                                               3      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +                             +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 5| 5| 6| 5| 5| 7| 7| 5| 5| 5| 6| 7| 5| 5| 7| 5| 6| 5| 7| 5| 6| 4|             
                             DAY ON TEST   | 2| 3| 6| 2| 6| 4| 9| 3| 3| 0| 6| 3| 6| 2| 3| 6| 2| 2| 4| 6| 6| 0| 4| 0| 6|             
                                           | 0| 7| 8| 3| 9| 2| 0| 4| 3| 5| 5| 4| 9| 2| 3| 7| 8| 1| 0| 5| 9| 2| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +                                             |             
      Aorta, Mineralization                |                            3                                             |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  1  2        3  3  2  2  1  2  1  2     3  1  3  2  2  1  3  2|             
      Artery, Mineralization               |                            2                                             |             
      Atrium, Thrombosis                   |                   3        3                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2     2     1  2        2     2  2     2        1           2     2   |             
      Hypertrophy                          |                                                    2                     |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                    3     3               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                 2                    2  1        1  2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1        2  4  1        2  3        3     3     3        2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                      2                          2                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             1  2           1  1           1                 1  1  1  1   |             
      Follicular Cell, Hyperplasia         | 1                                                  2           2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                 2                        |             
      Hyperplasia                          |                                                                          |             
      Necrosis, Fatty                      |                                                             3            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                   3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                            3                             3           3   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 5| 5| 6| 5| 5| 7| 7| 5| 5| 5| 6| 7| 5| 5| 7| 5| 6| 5| 7| 5| 6| 4|             
                             DAY ON TEST   | 2| 3| 6| 2| 6| 4| 9| 3| 3| 0| 6| 3| 6| 2| 3| 6| 2| 2| 4| 6| 6| 0| 4| 0| 6|             
                                           | 0| 7| 8| 3| 9| 2| 0| 4| 3| 5| 5| 4| 9| 2| 3| 7| 8| 1| 0| 5| 9| 2| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 3           3            |             
      Artery, Inflammation, Chronic Active |                                           3              2     2     2   |             
      Interstitial Cell, Hyperplasia       |    1                                                  2        1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +     +  +     +           +  +     +               |             
      Pancreatic, Hemorrhage               |                            2                                             |             
      Renal, Hemorrhage                    |                            2        2                    2               |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hemorrhage                           |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            1                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                X                                                         |             
      Fibrosis                             |    2           3     3     3  2        2  3     2        2           3   |             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
      Necrosis                             |                   2                                3                     |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  M  M  M  +  +  +  M  +  M  +  +  +  +  M  M  +  M  +  +  +|             
      Galactocele                          |                            3                 3                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             3                          3  3                 4           4|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                2                             2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 5| 5| 6| 5| 5| 7| 7| 5| 5| 5| 6| 7| 5| 5| 7| 5| 6| 5| 7| 5| 6| 4|             
                             DAY ON TEST   | 2| 3| 6| 2| 6| 4| 9| 3| 3| 0| 6| 3| 6| 2| 3| 6| 2| 2| 4| 6| 6| 0| 4| 0| 6|             
                                           | 0| 7| 8| 3| 9| 2| 0| 4| 3| 5| 5| 4| 9| 2| 3| 7| 8| 1| 0| 5| 9| 2| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    32 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                             3            |             
      Inflammation, Chronic Active         |                            3                                             |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    3                       3        1     2                    2  4      |             
      Artery, Mediastinum, Mineralization  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2  2                       2                                             |             
      Thrombosis                           |                   3                                                      |             
      Olfactory Epithelium, Atrophy        | 3  3     2     2  2  3  2  2  2  2  2  2  2  2  1  1  3  2  2  3  3  3   |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Basal Cell                      | 2  2     3  1  2  2  2  2  2  1     2  1  1  1  1  1  2  1  1  3  2  2  1|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Adenomatous                     |                                                                          |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic Active                  |                                                       1        1  2      |             
      Olfactory Epithelium, Metaplasia     | 1  3     1     2  2  1  2  2  2  2  2  2  2  2  1  1  2  2  2  3  2  2   |             
      Olfactory Epithelium, Necrosis       | 3  2              2  3     1           3           1  1  2  3  3  2  3  2|             
      Turbinate, Fibrosis, Focal           |          1  1                       1                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Cataract                             |    3                                                                     |             
      Retina, Atrophy                      |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            2              2                              |             
      Infarct                              |                3                                                         |             
      Mineralization                       |                            2                                             |             
      Nephropathy                          | 4  2  2  2  2  3  3  2  4  4  3  3  3  3  4  2  2  4  2  4  3  4  2  4  3|             
      Renal Tubule, Hyperplasia            |                            3                             2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5| 7| 7| 6| 6| 6| 5| 5| 5| 7| 7| 5| 6| 5| 6| 6| 5| 4| 6| 4|            |
                             DAY ON TEST   | 7| 0| 2| 2| 9| 0| 0| 3| 8| 2| 5| 9| 6| 1| 3| 3| 8| 8| 2| 0| 2| 8| 9| 6| 6|            |
                                           | 9| 6| 5| 1| 7| 5| 7| 3| 1| 2| 2| 5| 1| 2| 3| 3| 4| 1| 4| 9| 2| 5| 7| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                              X                           |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
      Parasite Metazoan                    | X                                                                    X   |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Necrosis                             |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |    2              1                       2              2               |      6  1.7|
      Basophilic Focus                     |       X  X           X  X  X        X     X  X  X  X              X  X   |     21     |
      Clear Cell Focus                     |                   X                       X  X                           |      3     |
      Degeneration, Cystic                 | 2  2  1  2        1     2     2           2              1           2   |     20  2.0|
      Degeneration, Fatty                  |                3                    2                       2            |      4  2.3|
      Eosinophilic Focus                   |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           |    X                                                                     |      4     |
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis                             |       2                                                                  |      1  2.0|
      Regeneration                         |                                                                          |      3  2.7|
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 3  2  1                 2  1  1  1     2  1     1  3  3  2  2  3     2  2|     35  1.9|
      Centrilobular, Necrosis              |          2  2                          1                 1     1         |     13  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +           +           +  +     +        +                    +   |  18        |
      Artery, Mineralization               |                   3                                                      |      1  3.0|
      Fat, Necrosis                        |       2                          2     2        2                    2   |     14  2.1|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 2     2     2  2        1  2     1        3     1  3  2  2  1  1         |     30  1.7|
      Basophilic Focus                     |                                                                         X|      2     |
      Hyperplasia                          |                   2                                                      |      5  2.0|
      Artery, Inflammation                 |                   4                                                      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |          2                                                     3         |      2  2.5|
      Mineralization                       |                   2                                                      |      1  2.0|
      Necrosis                             |                         2                                                |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5| 7| 7| 6| 6| 6| 5| 5| 5| 7| 7| 5| 6| 5| 6| 6| 5| 4| 6| 4|            |
                             DAY ON TEST   | 7| 0| 2| 2| 9| 0| 0| 3| 8| 2| 5| 9| 6| 1| 3| 3| 8| 8| 2| 0| 2| 8| 9| 6| 6|            |
                                           | 9| 6| 5| 1| 7| 5| 7| 3| 1| 2| 2| 5| 1| 2| 3| 3| 4| 1| 4| 9| 2| 5| 7| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |       3        4           3        4                                    |      6  3.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                   3                                                  2   |      3  2.7|
      Necrosis                             |                      4                 2                          2      |      6  2.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |          +                                                           +   |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +        +                                                      |   3        |
      Aorta, Mineralization                |                   4                                                      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2     2     1  2  4  2  2  2  2  1  2     2  2  2           3     2     2|     39  2.0|
      Artery, Mineralization               |                   4                                                      |      2  3.0|
      Atrium, Thrombosis                   |          4        4                                                      |      4  3.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2        2           1  3  2  2  1  2     2  2  2        2  2     2      |     26  1.9|
      Hypertrophy                          |                                                                          |      1  2.0|
      Necrosis                             |                                                       3                  |      1  3.0|
      Vacuolization Cytoplasmic            |                                           3                              |      3  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 3     2              1        2  1  2  2  3  3  1        2  1  2         |     19  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       2           2                                                      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1     2        2  4        3        3                    1  3  2         |     19  2.4|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |                   3                    3           2                     |      5  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 1              1  2     1  3     2  1        1  1  1        2  1  2  2   |     23  1.3|
      Follicular Cell, Hyperplasia         |                                                                      2   |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |             +                 +                                +         |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Hyperplasia                          |             3  3  3           3                    3           3         |      6  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5| 7| 7| 6| 6| 6| 5| 5| 5| 7| 7| 5| 6| 5| 6| 6| 5| 4| 6| 4|            |
                             DAY ON TEST   | 7| 0| 2| 2| 9| 0| 0| 3| 8| 2| 5| 9| 6| 1| 3| 3| 8| 8| 2| 0| 2| 8| 9| 6| 6|            |
                                           | 9| 6| 5| 1| 7| 5| 7| 3| 1| 2| 2| 5| 1| 2| 3| 3| 4| 1| 4| 9| 2| 5| 7| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Fatty                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                             1            |      1  1.0|
      Inflammation, Chronic Active         |                   4     2                                                |      3  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2           1                                2     2                 2   |      5  1.8|
      Inflammation, Chronic Active         |                                                             3            |      4  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                      3                                                   |      1  3.0|
      Mineralization                       |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          4        3                                                      |      4  3.3|
      Artery, Inflammation, Chronic Active |                                                                          |      4  2.3|
      Interstitial Cell, Hyperplasia       | 1  1           1           1                       3  2                  |      9  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                               +                    +  +  +               |  11        |
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      3  2.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|  44        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +|  44        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Spleen                     |                                                                          |      1     |
      Fibrosis                             | 2  2  2                    2              3  2                       3   |     17  2.4|
      Hematopoietic Cell Proliferation     |             4                 3                                          |      3  3.0|
      Necrosis                             |                                                                3         |      3  2.7|
      Thrombosis                           |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +  +  +  +  +  M  +  +  M  +  +  M  M  +  M  M  +  M  +  +  M  M|  30        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5| 7| 7| 6| 6| 6| 5| 5| 5| 7| 7| 5| 6| 5| 6| 6| 5| 4| 6| 4|            |
                             DAY ON TEST   | 7| 0| 2| 2| 9| 0| 0| 3| 8| 2| 5| 9| 6| 1| 3| 3| 8| 8| 2| 0| 2| 8| 9| 6| 6|            |
                                           | 9| 6| 5| 1| 7| 5| 7| 3| 1| 2| 2| 5| 1| 2| 3| 3| 4| 1| 4| 9| 2| 5| 7| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Galactocele                          |                                     3                                    |      3  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                2                 3                       3               |      8  3.1|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |       2  1        4        2        1                       2            |      7  2.1|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |                   3                                                      |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |    1  1        1              1  2  2     1              2               |     14  1.9|
      Artery, Mediastinum, Mineralization  |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                   3                                                      |      4  2.3|
      Thrombosis                           |                                        4                       2         |      3  3.0|
      Olfactory Epithelium, Atrophy        | 2  1  3  1  1  3  3  4  1  4  2  2  3  3  2  1  2  1  1  3  3  1  3  2   |     46  2.2|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Basal Cell                      | 1  1  2  2  2     1  2  1           2  1  1              2  2  1     1   |     38  1.6|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Adenomatous                     |                   2                                                      |      1  2.0|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic Active                  |                   3  3     1        1           1                 1      |      9  1.6|
      Olfactory Epithelium, Metaplasia     | 1     2  1  1  2  3  4  1  2  2  1  2  3  1  1  2  1  1  2  1  1  2  1   |     45  1.8|
      Olfactory Epithelium, Necrosis       |       1  2     2     2  1  2        1  3              1     2     3  1   |     26  2.0|
      Turbinate, Fibrosis, Focal           |                                        1        1                        |      5  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5| 7| 7| 6| 6| 6| 5| 5| 5| 7| 7| 5| 6| 5| 6| 6| 5| 4| 6| 4|            |
                             DAY ON TEST   | 7| 0| 2| 2| 9| 0| 0| 3| 8| 2| 5| 9| 6| 1| 3| 3| 8| 8| 2| 0| 2| 8| 9| 6| 6|            |
                                           | 9| 6| 5| 1| 7| 5| 7| 3| 1| 2| 2| 5| 1| 2| 3| 3| 4| 1| 4| 9| 2| 5| 7| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    32 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Retina, Atrophy                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                            2                                             |      3  2.0|
      Infarct                              |                                                                3         |      2  3.0|
      Mineralization                       |                   3                                                      |      2  2.5|
      Nephropathy                          | 3  2  4  4  1  4  4  4  4  4  4  3  4  2  3  4  4  3  2  3  4  2  3  3  2|     50  3.1|
      Renal Tubule, Hyperplasia            |          3     4                                         2  1            |      6  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 6| 6| 6| 6| 5| 5| 5| 6| 7| 6| 7| 6| 3| 6| 6| 6| 7| 5| 4| 6| 5|             
                             DAY ON TEST   | 2| 5| 3| 0| 6| 7| 4| 4| 9| 4| 6| 2| 3| 9| 3| 2| 0| 0| 0| 6| 3| 3| 6| 1| 8|             
                                           | 2| 8| 3| 9| 3| 3| 9| 6| 7| 9| 7| 5| 3| 3| 3| 5| 7| 3| 1| 7| 3| 0| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                       X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               1              3           2               |             
      Basophilic Focus                     | X           X     X  X                    X  X        X  X              X|             
      Clear Cell Focus                     |                         X                                X               |             
      Degeneration, Cystic                 |    1  2  2  1        1        2  2  3  3  1              2  2           2|             
      Degeneration, Fatty                  |    2                                                                     |             
      Eosinophilic Focus                   |                                                    X                    X|             
      Hepatodiaphragmatic Nodule           |                      X           X                                       |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                             2            |             
      Bile Duct, Hyperplasia               |    2  1  2  1  2  2     1  1  2  3  3  3  1  2     1  1     2  1  2  3   |             
      Centrilobular, Necrosis              | 3        2                                   2                    4      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +           +  +           +     +        +                  |             
      Inflammation, Chronic Active         |                                        4                                 |             
      Fat, Necrosis                        |          2              2  2                 2        3                  |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                      +           +                                   +   |             
      Pharyngeal, Hyperplasia, Squamous    |                                                                      3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2           1     2  2              2  1  2  1     2  2     2   |             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |       2                                                                  |             
      Inflammation, Chronic Active         |       2              2        3     3              3                     |             
      Necrosis                             |                   2                                      2               |             
      Ulcer                                | 3  4                 2        3     3  4                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             2                 1           3                 3            |             
      Necrosis                             |                                                                   2      |             
                                            __________________________________________________________________________|             
   Tongue                                  |       +        +  +                 +                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 6| 6| 6| 6| 5| 5| 5| 6| 7| 6| 7| 6| 3| 6| 6| 6| 7| 5| 4| 6| 5|             
                             DAY ON TEST   | 2| 5| 3| 0| 6| 7| 4| 4| 9| 4| 6| 2| 3| 9| 3| 2| 0| 0| 0| 6| 3| 3| 6| 1| 8|             
                                           | 2| 8| 3| 9| 3| 3| 9| 6| 7| 9| 7| 5| 3| 3| 3| 5| 7| 3| 1| 7| 3| 0| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Aorta, Mineralization                |                                                             2            |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  1  2  3  2  2  2  1  2  2  2  2  1        1  2  3  2  2  2  2  1|             
      Atrium, Thrombosis                   |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  2  1           2  2  2     2                    2     2  2     1     2|             
      Hypertrophy                          |                               2                                          |             
      Necrosis                             |                2                                                         |             
      Vacuolization Cytoplasmic            |                               2              2                           |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3              1  2  2     3  2        3  2     2  1  3     1     2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2     3     2  3           1  2  3  3        4     3  4        2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                     4                             2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1     1  1     1     1  1     1  1  1     1     2  1  2     2  1  1   |             
      Follicular Cell, Hyperplasia         |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1           1                                                   |             
      Inflammation, Chronic Active         |             4                 2                    2                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2                                                            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Artery, Inflammation, Chronic Active |             2  3                                                         |             
      Interstitial Cell, Hyperplasia       | 1                                1              1     1        1     2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 6| 6| 6| 6| 5| 5| 5| 6| 7| 6| 7| 6| 3| 6| 6| 6| 7| 5| 4| 6| 5|             
                             DAY ON TEST   | 2| 5| 3| 0| 6| 7| 4| 4| 9| 4| 6| 2| 3| 9| 3| 2| 0| 0| 0| 6| 3| 3| 6| 1| 8|             
                                           | 2| 8| 3| 9| 3| 3| 9| 6| 7| 9| 7| 5| 3| 3| 3| 5| 7| 3| 1| 7| 3| 0| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +  +  +              +  +                     |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    |                                                 2  2                     |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2     2                          2     2  3  3  2     2  3               |             
      Hematopoietic Cell Proliferation     |                                                 3              4  3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  M  M  M  +  M  M  +  M  M  +  M  +  +  M  M  M  +  +  +  +  M  +|             
      Galactocele                          |                                                                         3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |       3                 3           3                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                        3  2        3     1  3            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                           3                              |             
      Mineralization                       |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   X                                                      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                         1                                                |             
      Mineralization                       |                                                             2            |             
      Alveolar Epithelium, Hyperplasia     | 1  1              2  1        1  1     1           1  1  2  4        1  1|             
      Artery, Mediastinum, Mineralization  |                                                             2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   3      |             
      Thrombosis                           |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 6| 6| 6| 6| 5| 5| 5| 6| 7| 6| 7| 6| 3| 6| 6| 6| 7| 5| 4| 6| 5|             
                             DAY ON TEST   | 2| 5| 3| 0| 6| 7| 4| 4| 9| 4| 6| 2| 3| 9| 3| 2| 0| 0| 0| 6| 3| 3| 6| 1| 8|             
                                           | 2| 8| 3| 9| 3| 3| 9| 6| 7| 9| 7| 5| 3| 3| 3| 5| 7| 3| 1| 7| 3| 0| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    80 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Atrophy        | 4  4  3  4  4     4  4  4  3  3  3  4  4  4  4  3  4  4  4  4  3  3  4  3|             
      Olfactory Epithelium, Fibrosis       | 2  3  3  4  3     3  4  3  2  2  3  3  3  3  4     3  2  3  2  3  3  3  3|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Basal Cell                      | 1  2  2     3     3  3  3  1  1  2  3  2  3  3  2  3  2  2  1  2  3  2  2|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Adenomatous                     | 2  2  2  1  2     2  2  1     2  2  2  3  3  3  1  3  1  3  3  2        2|             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic Active                  | 3  2  2  3  2     2  3  3  3  3  3  4  3  2  4  2  4  2  4  4  3  3  2  2|             
      Olfactory Epithelium, Metaplasia     | 3  4  3  4  4     3  4  3  3  3  3  4  4  3  4  3  4  4  4  4  2  2  3  2|             
      Olfactory Epithelium, Necrosis       |    1     1                    3        3           3  3  2        3      |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      External Ear, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             3            |             
      Hyperplasia, Oncocytic               |                      1                                                   |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 4  4  4  2  4  4  4  4  4  3  4  4  4  4  4  3  1  4  3  4  4  3  2  4  3|             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Hyperplasia            |             4                                                            |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 6| 3| 6| 6| 5| 6| 7| 6| 6| 7| 5| 5| 5| 4| 5| 6| 6| 7| 4| 6| 7|            |
                             DAY ON TEST   | 1| 2| 6| 3| 5| 0| 0| 1| 7| 6| 0| 7| 2| 0| 3| 7| 4| 7| 3| 5| 9| 2| 9| 6| 1|            |
                                           | 7| 8| 3| 9| 1| 5| 8| 3| 8| 0| 2| 2| 5| 2| 3| 6| 0| 0| 2| 1| 1| 8| 7| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                     X           X                        |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |    X                 X     X                             X               |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              2                 1         |      5  1.8|
      Basophilic Focus                     |             X     X                                X           X         |     13     |
      Clear Cell Focus                     |                                                                          |      2     |
      Degeneration, Cystic                 |                   2        2  1  2  2  2                    2        3   |     21  1.9|
      Degeneration, Fatty                  |                                           2        2                     |      3  2.0|
      Eosinophilic Focus                   |                            X                 X                           |      4     |
      Hepatodiaphragmatic Nodule           |                                                                   X      |      3     |
      Mixed Cell Focus                     |                         X                                                |      1     |
      Necrosis                             |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |       3     1     2  1  1     2  1  2  2        2           3  3     3  2|     34  1.9|
      Centrilobular, Necrosis              |       1           1                 1                       2            |      8  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +           +  +     +                    +           +|  13        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Fat, Necrosis                        |                   2           2  2     2                    2           3|     11  2.2|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                         +     +                 +        +               |   7        |
      Pharyngeal, Hyperplasia, Squamous    |                         3     2                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3  2     1  1           2        2  3  2        2     2  3              2|     23  1.9|
      Basophilic Focus                     |                   X                                                      |      1     |
      Hyperplasia                          |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      5  2.6|
      Necrosis                             |                                                                3         |      3  2.3|
      Ulcer                                |                               4           3        4        3        4   |     11  3.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                         3|      5  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 6| 3| 6| 6| 5| 6| 7| 6| 6| 7| 5| 5| 5| 4| 5| 6| 6| 7| 4| 6| 7|            |
                             DAY ON TEST   | 1| 2| 6| 3| 5| 0| 0| 1| 7| 6| 0| 7| 2| 0| 3| 7| 4| 7| 3| 5| 9| 2| 9| 6| 1|            |
                                           | 7| 8| 3| 9| 1| 5| 8| 3| 8| 0| 2| 2| 5| 2| 3| 6| 0| 0| 2| 1| 1| 8| 7| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                             3            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |       +  +  +                                                  +         |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  2  2        3  1  2  2  2  2  2  1  2     2  1  2  3  2  2  1  2|     45  1.8|
      Atrium, Thrombosis                   |                                                             3            |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       1              2  1     2     2        2        2  3        1  2  2|     23  1.8|
      Hypertrophy                          |                                                                          |      1  2.0|
      Necrosis                             |                                                             3            |      2  2.5|
      Vacuolization Cytoplasmic            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             3                                   2  2                 1   |     17  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2     2                                                                  |      3  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2  2  1     2        3  3        3  1  2                 3     4  3|     24  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|  49        |
      Pars Distalis, Hyperplasia           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1  1     1     1     1  1              1  1     2     1     1         |     28  1.1|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                      3   |      1  3.0|
      Inflammation, Chronic Active         |    2  3                                      2                       2   |      4  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2                                                                     |      4  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 6| 3| 6| 6| 5| 6| 7| 6| 6| 7| 5| 5| 5| 4| 5| 6| 6| 7| 4| 6| 7|            |
                             DAY ON TEST   | 1| 2| 6| 3| 5| 0| 0| 1| 7| 6| 0| 7| 2| 0| 3| 7| 4| 7| 3| 5| 9| 2| 9| 6| 1|            |
                                           | 7| 8| 3| 9| 1| 5| 8| 3| 8| 0| 2| 2| 5| 2| 3| 6| 0| 0| 2| 1| 1| 8| 7| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                3  2                                                      |      5  2.6|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       3                                                                  |      1  3.0|
      Artery, Inflammation, Chronic Active |                                  2                                       |      3  2.3|
      Interstitial Cell, Hyperplasia       |                                                             1            |      7  1.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +                    +           +  +  +        +  +        +  +|  15        |
      Renal, Ectasia                       |          2                                                               |      1  2.0|
      Renal, Hemorrhage                    |                               2              2                       2   |      5  2.0|
      Renal, Pigmentation                  |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Plasma Cell   |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |             2     3           1     2  2     2  3        2     2     3  2|     20  2.3|
      Hematopoietic Cell Proliferation     | 2        2                                            3                  |      6  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  M  M  +  M  +  M  M  M  +  M  +  M  +  +  +  +  +  +|  28        |
      Galactocele                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                            3                                             |      1  3.0|
      Inflammation, Chronic Active         |                   4                                      2               |      5  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                            2  2        2                       2     2  2|     11  2.2|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 6| 3| 6| 6| 5| 6| 7| 6| 6| 7| 5| 5| 5| 4| 5| 6| 6| 7| 4| 6| 7|            |
                             DAY ON TEST   | 1| 2| 6| 3| 5| 0| 0| 1| 7| 6| 0| 7| 2| 0| 3| 7| 4| 7| 3| 5| 9| 2| 9| 6| 1|            |
                                           | 7| 8| 3| 9| 1| 5| 8| 3| 8| 0| 2| 2| 5| 2| 3| 6| 0| 0| 2| 1| 1| 8| 7| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     | 2           1        1                 1  1  2        2  1  2  1  1  1   |     25  1.4|
      Artery, Mediastinum, Mineralization  |                                                                         2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  3.0|
      Thrombosis                           |                                                             2            |      2  2.0|
      Olfactory Epithelium, Atrophy        | 3  3  3  3  4  2  4  3  3  4  4  4  3  3  4  4  4  3     4  4  4  3  4  4|     48  3.6|
      Olfactory Epithelium, Fibrosis       | 3  2  3  2  3  3  3  2  2  3  4  2  3  3  3  3  2  2     2  2  2  1  3  2|     47  2.7|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Basal Cell                      | 3  1  2  2  3  3  3  1  2  2  2  1  3  3  4  3     3     1  2  2  2  3  1|     46  2.2|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Adenomatous                     | 2  2  1  1     1  2     2  3  3  2  2     2  1  2  1     2  2  3  1  1  3|     42  2.0|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic Active                  | 2  2  3  1  1  2  3  3  2  2  4  3  2  1  2  3  4  2  3  4  2  4  2  3  3|     49  2.7|
      Olfactory Epithelium, Metaplasia     | 2  3  2  2  3  2  3  2  2  3  4  4  2  3  4  3  4  3     3  4  3  2  3  3|     48  3.1|
      Olfactory Epithelium, Necrosis       |          3  3     4  2        2  3  1  1     1     1              2      |     19  2.2|
      Respiratory Epithelium, Hyperplasia  |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                 +                        |   1        |
      External Ear, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                 +                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                            2        2                          2        2|      5  2.2|
      Hyperplasia, Oncocytic               |                            4                                             |      2  2.5|
      Mineralization                       |                                                                         2|      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05136-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            CHLOROPRENE                                        Date: 09/13/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:12:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 6| 3| 6| 6| 5| 6| 7| 6| 6| 7| 5| 5| 5| 4| 5| 6| 6| 7| 4| 6| 7|            |
                             DAY ON TEST   | 1| 2| 6| 3| 5| 0| 0| 1| 7| 6| 0| 7| 2| 0| 3| 7| 4| 7| 3| 5| 9| 2| 9| 6| 1|            |
                                           | 7| 8| 3| 9| 1| 5| 8| 3| 8| 0| 2| 2| 5| 2| 3| 6| 0| 0| 2| 1| 1| 8| 7| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    80 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy                          | 3  3  4  4  4  1  4  3  3  4  4  4  3  4  4  4  3  4  3  3  3  4  3  4  4|     50  3.5|
      Pelvis, Inflammation, Acute          |                                           2                              |      1  2.0|
      Renal Tubule, Hyperplasia            |             1              1     1           1                 3         |      6  1.8|
      Transitional Epithelium, Hyperplasia |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                4                                                         |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
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