TDMS Study 05142-04 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
T-BUTYL ALCOHOL
NTP Experiment-Test: 05142-04 Report: PEIRPT03
Study Type: CHRONIC Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
Facility: Southern Research Institute
Chemical CAS #: 75-65-0
Lock Date: 01/23/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05142-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.5% 1.0% 2.0%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Moribund Sacrifice 13 14 13 12
Natural Death 10 8 4 4
Accidently Killed 1 3 2 2
Survivors
Terminal Sacrifice 36 35 40 42
Natural Death 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (58) (59) (58) (56)
Mucosa, Hyperplasia 1 (2%) 1 (2%)
Intestine Small, Duodenum (58) (57) (56) (60)
Inflammation, Chronic 1 (2%)
Perforation 1 (2%)
Ulcer 1 (2%) 1 (2%)
Intestine Small, Jejunum (57) (56) (57) (60)
Developmental Malformation 1 (2%)
Hyperplasia, Lymphoid 2 (3%)
Liver (59) (60) (59) (60)
Basophilic Focus 3 (5%) 1 (2%) 2 (3%)
Clear Cell Focus 5 (8%) 3 (5%)
Eosinophilic Focus 13 (22%) 14 (23%) 16 (27%) 20 (33%)
Fatty Change 11 (19%) 8 (13%) 8 (14%) 6 (10%)
Fibrosis, Focal 1 (2%) 1 (2%) 1 (2%)
Focal Cellular Change 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 5 (8%)
Hemorrhage 1 (2%) 1 (2%)
Infarct 1 (2%) 2 (3%) 2 (3%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Focal 5 (8%) 2 (3%) 7 (12%) 3 (5%)
Mineralization, Focal 1 (2%)
Mixed Cell Focus 2 (3%) 5 (8%) 7 (12%) 4 (7%)
Necrosis 1 (2%)
Necrosis, Focal 2 (3%) 1 (2%) 2 (3%) 1 (2%)
Pigmentation 1 (2%) 3 (5%) 3 (5%)
Tension Lipidosis 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Centrilobular, Atrophy 1 (2%)
Centrilobular, Fibrosis 1 (2%) 1 (2%)
Centrilobular, Necrosis 2 (3%) 2 (3%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05142-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.5% 1.0% 2.0%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (24) (17) (17) (12)
Cyst 1 (6%)
Hemorrhage 1 (4%) 1 (6%)
Inflammation, Chronic 2 (8%) 2 (12%) 1 (6%)
Fat, Necrosis 14 (58%) 10 (59%) 12 (71%) 4 (33%)
Pancreas (59) (59) (59) (59)
Atrophy, Focal 3 (5%) 3 (5%) 1 (2%)
Acinar Cell, Focal Cellular Change 1 (2%)
Duct, Dilatation 2 (3%) 1 (2%)
Stomach, Forestomach (60) (60) (59) (60)
Cyst 1 (2%)
Erosion 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 4 (7%) 2 (3%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Ulcer 2 (3%) 1 (2%) 1 (2%)
Mucosa, Hyperplasia 3 (5%) 5 (8%) 5 (8%) 4 (7%)
Stomach, Glandular (60) (60) (59) (59)
Angiectasis 1 (2%)
Erosion 1 (2%) 1 (2%)
Mineralization 1 (2%)
Pigmentation 1 (2%) 1 (2%)
Ulcer 1 (2%)
Mucosa, Hyperplasia 2 (3%)
Tooth (3) (2) (1) (3)
Incisor, Dysplasia 3 (100%) 2 (100%) 1 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Bacterium 1 (100%)
Aorta, Inflammation, Focal, Suppurative 1 (100%)
Aorta, Thrombosis 1 (100%)
Heart (60) (60) (60) (60)
Hemorrhage 1 (2%)
Inflammation, Focal, Suppurative 1 (2%)
Mineralization, Focal 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Congestion 1 (2%)
Focal Cellular Change 2 (3%) 3 (5%)
Hematopoietic Cell Proliferation 1 (2%)
Subcapsular, Hyperplasia, Focal 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05142-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.5% 1.0% 2.0%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Adrenal Medulla (60) (60) (60) (60)
Congestion 1 (2%)
Parathyroid Gland (48) (56) (57) (50)
Cyst 1 (2%)
Pituitary Gland (56) (57) (60) (60)
Angiectasis 1 (2%) 2 (4%) 1 (2%)
Cyst 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 2 (3%)
Pars Distalis, Focal Cellular Change 6 (11%) 6 (11%) 6 (10%) 2 (3%)
Pars Distalis, Hyperplasia, Focal 1 (2%) 5 (9%) 5 (8%) 1 (2%)
Thyroid Gland (58) (60) (59) (59)
Degeneration, Cystic 8 (14%) 9 (15%) 9 (15%) 4 (7%)
Inflammation, Focal 1 (2%) 1 (2%)
C-Cell, Hyperplasia 2 (3%)
Follicle, Cyst 1 (2%) 1 (2%)
Follicular Cell, Cyst 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 19 (33%) 28 (47%) 33 (56%) 47 (80%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1) (2) (2) (1)
Degeneration, Cystic 1 (100%) 2 (100%) 1 (50%) 1 (100%)
Ovary (58) (58) (60) (59)
Angiectasis 1 (2%) 2 (3%) 1 (2%) 1 (2%)
Hemorrhage 3 (5%) 1 (2%) 2 (3%)
Necrosis 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Follicle, Cyst 15 (26%) 13 (22%) 17 (28%) 12 (20%)
Periovarian Tissue, Hemorrhage 1 (2%)
Uterus (60) (60) (59) (59)
Angiectasis 1 (2%) 2 (3%) 1 (2%) 1 (2%)
Atrophy 1 (2%)
Decidual Reaction 1 (2%)
Exudate 1 (2%)
Hemorrhage 1 (2%)
Hydrometra 20 (33%) 25 (42%) 19 (32%) 27 (46%)
Inflammation, Suppurative 4 (7%) 1 (2%) 1 (2%) 3 (5%)
Endometrium, Hyperplasia, Cystic 58 (97%) 59 (98%) 58 (98%) 56 (95%)
Lymphatic, Ectasia 1 (2%)
Vagina (1)
Epithelium, Metaplasia 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05142-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.5% 1.0% 2.0%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (60) (60) (60)
Angiectasis 1 (2%)
Hypercellularity 1 (2%)
Lymph Node (19) (12) (6) (13)
Bronchial, Hyperplasia, Lymphoid 1 (5%)
Iliac, Angiectasis 1 (5%) 1 (8%)
Iliac, Hematopoietic Cell Proliferation 1 (5%)
Iliac, Hyperplasia 1 (5%) 1 (8%) 1 (8%)
Inguinal, Hyperplasia, Lymphoid 1 (17%) 1 (8%)
Inguinal, Hyperplasia, Mast Cell 1 (8%)
Mediastinal, Angiectasis 1 (5%) 1 (8%)
Mediastinal, Hyperplasia 2 (33%)
Mediastinal, Hyperplasia, Lymphoid 3 (16%)
Renal, Hematopoietic Cell Proliferation 1 (5%)
Renal, Hyperplasia 1 (5%) 1 (8%)
Lymph Node, Mandibular (59) (58) (59) (57)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (3%) 1 (2%)
Lymph Node, Mesenteric (56) (59) (57) (57)
Angiectasis 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 8 (14%) 10 (17%) 4 (7%) 4 (7%)
Hyperplasia, Macrophage 1 (2%)
Spleen (59) (60) (59) (59)
Depletion Cellular 3 (5%) 2 (3%) 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 27 (46%) 25 (42%) 28 (47%) 20 (34%)
Hyperplasia, Lymphoid 15 (25%) 18 (30%) 13 (22%) 18 (31%)
Pigmentation 1 (2%)
Thymus (57) (58) (53) (58)
Congestion 1 (2%)
Cyst 2 (4%)
Hyperplasia, Lymphoid 3 (5%) 5 (9%) 3 (6%) 2 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (60) (60)
Dilatation 4 (7%) 4 (7%) 3 (5%)
Inflammation, Chronic 1 (2%)
Skin (60) (60) (60) (60)
Inflammation, Chronic, Focal 1 (2%) 1 (2%) 1 (2%) 3 (5%)
Ulcer 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05142-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.5% 1.0% 2.0%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Epidermis, Hyperplasia, Focal 1 (2%)
Sebaceous Gland, Hyperplasia 1 (2%)
Subcutaneous Tissue, Edema 2 (3%) 2 (3%)
Subcutaneous Tissue, Hyperplasia, Mast Cell 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Fibrous Osteodystrophy 30 (50%) 34 (57%) 34 (57%) 23 (38%)
Hyperostosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 1 (2%) 3 (5%) 6 (10%) 2 (3%)
Cyst Epithelial Inclusion 1 (2%)
Hemorrhage 2 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (60) (60) (60)
Congestion 1 (2%) 2 (3%) 3 (5%)
Foreign Body 3 (5%)
Hemorrhage 1 (2%) 4 (7%)
Hyperplasia, Macrophage 1 (2%) 1 (2%) 2 (3%) 2 (3%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (5%) 2 (3%)
Nose (60) (60) (60) (60)
Foreign Body 1 (2%)
Inflammation, Suppurative 4 (7%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Pinna, Inflammation, Chronic, Focal 1 (100%)
Pinna, Ulcer 1 (100%)
Eye (1)
Atrophy 1 (100%)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05142-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.5% 1.0% 2.0%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (60) (59) (60)
Cyst 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 2 (3%) 2 (3%)
Nephropathy 40 (68%) 37 (62%) 36 (61%) 31 (52%)
Pelvis, Dilatation 1 (2%) 2 (3%)
Renal Tubule, Degeneration, Hyaline 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urinary Bladder (59) (60) (59) (57)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 4 (7%)
Transitional Epithelium, Hyperplasia 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05142-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 0.5% 1.0% 2.0%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Moribund Sacrifice 20 14 19 21
Natural Death 13 8 6 22
Accidently Killed 2 1
Survivors
Terminal Sacrifice 27 36 34 17
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (60) (60) (60)
Inflammation, Focal, Suppurative 1 (2%)
Gallbladder (55) (57) (59) (54)
Cyst 1 (2%)
Intestine Small, Duodenum (56) (56) (57) (56)
Ulcer 1 (2%)
Intestine Small, Jejunum (56) (56) (57) (55)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Ulcer 1 (2%)
Intestine Small, Ileum (56) (56) (57) (55)
Hyperplasia, Lymphoid 2 (4%)
Liver (59) (60) (59) (59)
Angiectasis 3 (5%) 1 (2%)
Basophilic Focus 2 (3%) 8 (13%) 10 (17%) 6 (10%)
Clear Cell Focus 10 (17%) 25 (42%) 21 (36%) 20 (34%)
Congestion 1 (2%)
Eosinophilic Focus 20 (34%) 24 (40%) 31 (53%) 10 (17%)
Fatty Change 12 (20%) 5 (8%) 8 (14%) 29 (49%)
Fibrosis, Focal 1 (2%)
Focal Cellular Change 2 (3%)
Hematopoietic Cell Proliferation 2 (3%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Infarct 2 (3%) 1 (2%) 2 (3%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Focal 2 (3%) 3 (5%)
Mixed Cell Focus 4 (7%) 4 (7%) 3 (5%) 5 (8%)
Necrosis, Focal 5 (8%) 3 (5%) 5 (8%) 1 (2%)
Tension Lipidosis 5 (8%)
Thrombosis 1 (2%)
Centrilobular, Necrosis 1 (2%) 1 (2%) 1 (2%)
Mesentery (5) (6) (7) (4)
Angiectasis 1 (25%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05142-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 0.5% 1.0% 2.0%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Cyst 1 (14%)
Hemorrhage 1 (20%)
Hyperplasia, Mast Cell 1 (17%)
Inflammation, Chronic 1 (20%) 2 (29%) 1 (25%)
Mineralization 1 (20%)
Fat, Necrosis 1 (20%) 3 (50%) 3 (43%) 2 (50%)
Pancreas (58) (59) (59) (57)
Atrophy, Focal 3 (5%) 2 (3%) 1 (2%)
Edema 1 (2%) 1 (2%)
Necrosis 1 (2%)
Duct, Dilatation 1 (2%)
Stomach, Forestomach (59) (59) (59) (58)
Erosion 2 (3%)
Inflammation, Chronic 6 (10%) 4 (7%) 1 (2%) 7 (12%)
Ulcer 1 (2%) 1 (2%) 1 (2%) 4 (7%)
Mucosa, Hyperplasia 7 (12%) 7 (12%) 1 (2%) 4 (7%)
Stomach, Glandular (59) (59) (59) (57)
Erosion 1 (2%) 3 (5%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%) 2 (4%)
Pigmentation 1 (2%) 3 (5%) 2 (4%)
Mucosa, Hyperplasia 4 (7%) 2 (4%)
Tooth (44) (41) (33) (26)
Incisor, Dysplasia 44 (100%) 41 (100%) 33 (100%) 26 (100%)
Incisor, Inflammation, Suppurative 1 (3%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Mesenteric Artery, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Accessory Adrenal Cortical Nodule 1 (2%) 2 (3%)
Cyst 1 (2%) 1 (2%) 1 (2%)
Focal Cellular Change 2 (3%) 6 (10%) 1 (2%) 1 (2%)
Subcapsular, Hyperplasia, Focal 5 (8%) 7 (12%) 7 (12%) 1 (2%)
Parathyroid Gland (55) (59) (56) (55)
Cyst 2 (4%) 2 (4%)
Degeneration, Cystic 1 (2%)
Pituitary Gland (52) (57) (56) (53)
Cyst 2 (4%) 1 (2%) 3 (6%)
Pars Distalis, Focal Cellular Change 1 (2%)
Thyroid Gland (60) (59) (59) (57)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05142-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 0.5% 1.0% 2.0%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Cyst 1 (2%)
Degeneration, Cystic 7 (12%) 5 (8%) 10 (17%) 5 (9%)
Inflammation, Focal 1 (2%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 5 (8%) 18 (31%) 15 (25%) 18 (32%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (23) (13) (21) (4)
Dilatation 23 (100%) 13 (100%) 21 (100%) 4 (100%)
Epididymis (60) (60) (60) (60)
Granuloma Sperm 4 (7%) 1 (2%) 2 (3%) 3 (5%)
Inflammation, Chronic 3 (5%) 1 (2%)
Penis (1)
Inflammation, Chronic 1 (100%)
Necrosis 1 (100%)
Preputial Gland (27) (36) (24) (21)
Degeneration, Cystic 26 (96%) 33 (92%) 23 (96%) 21 (100%)
Inflammation, Chronic 2 (7%) 5 (14%) 1 (4%) 1 (5%)
Prostate (60) (60) (60) (58)
Dilatation 2 (3%) 1 (2%) 2 (3%)
Inflammation, Chronic 2 (3%) 2 (3%) 1 (2%)
Seminal Vesicle (60) (60) (60) (60)
Congestion 1 (2%)
Dilatation 35 (58%) 31 (52%) 36 (60%) 11 (18%)
Hemorrhage 2 (3%) 3 (5%) 1 (2%) 2 (3%)
Inflammation, Chronic 2 (3%)
Testes (60) (60) (60) (59)
Angiectasis 1 (2%)
Degeneration 1 (2%)
Granuloma Sperm 1 (2%)
Mineralization 1 (2%) 1 (2%)
Germinal Epithelium, Degeneration 2 (3%) 6 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Angiectasis 1 (2%) 1 (2%)
Congestion 1 (2%)
Hypercellularity 2 (3%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05142-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 0.5% 1.0% 2.0%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Myelofibrosis, Focal 1 (2%)
Lymph Node (9) (5) (1) (1)
Angiectasis 1 (11%) 1 (100%)
Inguinal, Cyst 1 (100%)
Inguinal, Hyperplasia 1 (20%)
Inguinal, Hyperplasia, Lymphoid 2 (40%)
Mediastinal, Hyperplasia 3 (33%)
Mediastinal, Hyperplasia, Lymphoid 1 (11%)
Pancreatic, Hyperplasia 1 (20%)
Renal, Hyperplasia 1 (11%) 1 (20%)
Lymph Node, Mandibular (57) (59) (58) (56)
Hyperplasia 2 (4%) 2 (3%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Lymph Node, Mesenteric (59) (58) (57) (56)
Angiectasis 13 (22%) 23 (40%) 17 (30%) 13 (23%)
Hematopoietic Cell Proliferation 1 (2%) 4 (7%) 4 (7%)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 10 (17%) 6 (10%) 9 (16%) 8 (14%)
Spleen (59) (59) (59) (57)
Depletion Cellular 2 (3%) 6 (10%) 5 (8%) 25 (44%)
Fibrosis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 21 (36%) 14 (24%) 14 (24%) 11 (19%)
Hyperplasia, Lymphoid 7 (12%) 12 (20%) 8 (14%) 7 (12%)
Thymus (53) (54) (55) (52)
Cyst 9 (17%) 3 (6%) 7 (13%) 5 (10%)
Hyperplasia, Lymphoid 1 (2%)
Mineralization 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (60) (60)
Inflammation, Chronic, Focal 1 (2%) 2 (3%) 2 (3%)
Ulcer 1 (2%)
Epidermis, Hyperplasia, Focal 1 (2%) 1 (2%)
Hair Follicle, Atrophy 1 (2%)
Subcutaneous Tissue, Abscess 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05142-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 0.5% 1.0% 2.0%
CONTROL
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Fibrous Osteodystrophy 1 (2%)
Hyperostosis 2 (3%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Congestion 1 (2%) 1 (2%) 5 (8%)
Foreign Body 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Macrophage 4 (7%) 1 (2%) 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%) 2 (3%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic, Focal 2 (3%) 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (7%) 4 (7%) 2 (3%) 1 (2%)
Artery, Thrombosis 1 (2%)
Bronchus, Epithelium, Hyperplasia 1 (2%)
Nose (60) (60) (60) (59)
Inflammation, Suppurative 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1)
Inflammation, Chronic 1 (50%)
Harderian Gland (10) (3) (3) (1)
Inflammation, Chronic 1 (10%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (58) (59) (57)
Atrophy, Focal 1 (2%)
Congestion 1 (2%) 4 (7%)
Cyst 7 (12%) 4 (7%) 3 (5%) 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Nephropathy 51 (85%) 54 (93%) 55 (93%) 44 (77%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Pelvis, Dilatation 3 (5%) 1 (2%) 1 (2%) 1 (2%)
Renal Tubule, Degeneration, Hyaline 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05142-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 08:27:30
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 0.5% 1.0% 2.0%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Dilatation 2 (3%) 1 (2%) 3 (5%)
Ureter (1)
Dilatation 1 (100%)
Urethra (1) (2) (3)
Angiectasis 1 (50%)
Dilatation 1 (50%) 1 (33%)
Inflammation, Acute 1 (50%)
Inflammation, Chronic 1 (100%) 2 (67%)
Bulbourethral Gland, Angiectasis 1 (50%)
Urinary Bladder (59) (59) (58) (59)
Calculus Gross Observation, Multiple,
Greater Than Five 1 (2%)
Dilatation 3 (5%) 2 (3%) 2 (3%) 2 (3%)
Inflammation, Chronic 3 (5%) 1 (2%) 37 (63%)
Artery, Inflammation, Chronic 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 3 (5%) 1 (2%) 17 (29%)
a Number of animals examined microscopically at site and number of animals with lesion
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