TDMS Study 05142-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst T-BUTYL ALCOHOL DATE: 05/20/95
EXPERIMENT: 05142 TEST: 04 TIME: 08:42:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55121 ROUTE: DOSED WATER NTP C#: 55367B
PATHOLOGIST: DR. FARNELL CAS: 75-65-0
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst T-BUTYL ALCOHOL DATE: 05/20/95
EXPERIMENT: 05142 TEST: 04 TIME: 08:42:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55121 ROUTE: DOSED WATER NTP C#: 55367B
PATHOLOGIST: DR. FARNELL CAS: 75-65-0
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst T-BUTYL ALCOHOL DATE: 05/20/95
EXPERIMENT: 05142 TEST: 04 TIME: 08:42:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55121 ROUTE: DOSED WATER NTP C#: 55367B
PATHOLOGIST: DR. FARNELL CAS: 75-65-0
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF T-BUTYL ALCOHOL
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Hemangioma
Hemangiosarcoma or Hemangioma
Malignant Lymphoma And Histiocytic Sarcoma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Thyroid Gland: Follicular Cell
Adenoma
Carcinoma or Adenoma
All Organs Hemangioma
Hemangiosarcoma
Malignant Tumors
====================================================================================================
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 5/60 (8%) 2/60 (3%) 2/60 (3%) | 0/60 (0%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 13.7% 12.2% 5.9% 9.1% | 0.0% 2.9% 2.4% 0.0% |
|TERMINAL (d) | 3/27 (11%) 2/36 (6%) 2/34 (6%) 1/17 (6%) | 0/36 (0%) 1/35 (3%) 1/41 (2%) 0/42 (0%) |
|FIRST INCIDENCE (DAYS) | 707 706 728 (T) 628 | --- 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.356N P=0.592N P=0.240N P=0.566N | P=0.556N P=0.494 P=0.526 (e) |
|INCIDENTAL TUMOR | P=0.355N P=0.460 P=0.277N P=0.523N | P=0.556N P=0.494 P=0.526 (e) |
|LOGISTIC REGRESSION | P=0.344N P=0.619 P=0.248N P=0.545N | P=0.556N P=0.494 P=0.526 (e) |
|COCHRAN-ARMITAGE | P=0.180N | P=0.595N |
|FISHER EXACT | P=0.500 P=0.340N P=0.340N | P=0.500 P=0.500 (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 4.9% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/36 (0%) 0/34 (0%) 0/17 (0%) | 0/36 (0%) 0/35 (0%) 2/41 (5%) 0/42 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.630 (e) P=0.267 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.630 (e) P=0.267 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.630 (e) P=0.267 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.595 |
|FISHER EXACT | (e) (e) (e) | (e) P=0.248 (e) |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 8/60 (13%) 3/60 (5%) 2/60 (3%) 1/60 (2%) | 1/60 (2%) 1/60 (2%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 21.3% 7.6% 5.6% 2.3% | 2.8% 2.7% 2.4% 4.8% |
|TERMINAL (d) | 3/27 (11%) 2/36 (6%) 1/34 (3%) 0/17 (0%) | 1/36 (3%) 0/35 (0%) 1/41 (2%) 2/42 (5%) |
|FIRST INCIDENCE (DAYS) | 461 702 727 486 | 729 (T) 727 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.027N* P=0.057N P=0.032N* P=0.079N | P=0.410 P=0.754 P=0.733N P=0.554 |
|INCIDENTAL TUMOR | P=0.019N* P=0.142N P=0.070N P=0.038N* | P=0.403 P=0.754N P=0.733N P=0.554 |
|LOGISTIC REGRESSION | P=0.015N* P=0.104N P=0.049N* P=0.030N* | P=0.404 P=0.761 P=0.733N P=0.554 |
|COCHRAN-ARMITAGE | P=0.010N** | P=0.351 |
|FISHER EXACT | P=0.102N P=0.047N* P=0.016N* | P=0.752N P=0.752N P=0.500 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.8% 0.0% 2.9% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/36 (0%) 1/34 (3%) 0/17 (0%) | 0/36 (0%) 0/35 (0%) 0/41 (0%) 0/42 (0%) |
|FIRST INCIDENCE (DAYS) | 652 --- 728 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.250N P=0.206N P=0.449N P=0.352N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.264N P=0.260N P=0.488N P=0.373N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.237N P=0.238N P=0.486N P=0.319N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.188N | (e) |
|FISHER EXACT | P=0.248N P=0.500N P=0.248N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 3/60 (5%) 3/60 (5%) 1/60 (2%) | 1/60 (2%) 1/60 (2%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 26.2% 7.6% 8.4% 2.3% | 2.8% 2.7% 2.4% 4.8% |
|TERMINAL (d) | 4/27 (15%) 2/36 (6%) 2/34 (6%) 0/17 (0%) | 1/36 (3%) 0/35 (0%) 1/41 (2%) 2/42 (5%) |
|FIRST INCIDENCE (DAYS) | 461 702 727 486 | 729 (T) 727 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.013N* P=0.019N* P=0.023N* P=0.039N* | P=0.410 P=0.754 P=0.733N P=0.554 |
|INCIDENTAL TUMOR | P=0.009N** P=0.059N P=0.052N P=0.017N* | P=0.403 P=0.754N P=0.733N P=0.554 |
|LOGISTIC REGRESSION | P=0.007N** P=0.040N* P=0.038N* P=0.012N* | P=0.404 P=0.761 P=0.733N P=0.554 |
|COCHRAN-ARMITAGE | P=0.004N** | P=0.351 |
|FISHER EXACT | P=0.037N* P=0.037N* P=0.004N** | P=0.752N P=0.752N P=0.500 |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 0/60 (0%) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.7% 0.0% 5.6% 0.0% | 4.8% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/36 (0%) 1/34 (3%) 0/17 (0%) | 1/36 (3%) 0/35 (0%) 0/41 (0%) 0/42 (0%) |
|FIRST INCIDENCE (DAYS) | 689 --- 727 --- | 647 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.585N P=0.457N P=0.573 P=0.595N | P=0.103N P=0.243N P=0.221N P=0.210N |
|INCIDENTAL TUMOR | P=0.606N P=0.602N P=0.444 P=0.638N | P=0.106N P=0.233N P=0.225N P=0.214N |
|LOGISTIC REGRESSION | P=0.572N P=0.500N P=0.532 P=0.573N | P=0.112N P=0.233N P=0.231N P=0.231N |
|COCHRAN-ARMITAGE | P=0.461N | P=0.115N |
|FISHER EXACT | P=0.500N P=0.500 P=0.500N | P=0.248N P=0.248N P=0.248N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Intestine Small: Site Unspecified |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 0/60 (0%) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 2.7% 0.0% 5.6% 0.0% | 4.8% 0.0% 2.4% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/36 (0%) 1/34 (3%) 0/17 (0%) | 1/36 (3%) 0/35 (0%) 1/41 (2%) 0/42 (0%) |
|FIRST INCIDENCE (DAYS) | 689 --- 727 --- | 647 --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.585N P=0.457N P=0.573 P=0.595N | P=0.165N P=0.243N P=0.465N P=0.210N |
|INCIDENTAL TUMOR | P=0.606N P=0.602N P=0.444 P=0.638N | P=0.168N P=0.233N P=0.470N P=0.214N |
|LOGISTIC REGRESSION | P=0.572N P=0.500N P=0.532 P=0.573N | P=0.179N P=0.233N P=0.482N P=0.231N |
|COCHRAN-ARMITAGE | P=0.461N | P=0.188N |
|FISHER EXACT | P=0.500N P=0.500 P=0.500N | P=0.248N P=0.500N P=0.248N |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/58 (3%) 0/59 (0%) 1/57 (2%) | 0/59 (0%) 0/60 (0%) 0/59 (0%) 1/60 (2%) |
|ADJUSTED (b) | 3.7% 5.6% 0.0% 5.6% | 0.0% 0.0% 0.0% 2.4% |
|TERMINAL (d) | 1/27 (4%) 2/36 (6%) 0/34 (0%) 0/17 (0%) | 0/36 (0%) 0/35 (0%) 0/41 (0%) 1/42 (2%) |
|FIRST INCIDENCE (DAYS) | 728 (T) 728 (T) --- 727 | --- --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.648N P=0.600 P=0.454N P=0.656 | P=0.221 (e) (e) P=0.531 |
|INCIDENTAL TUMOR | P=0.644 P=0.600 P=0.454N P=0.627 | P=0.221 (e) (e) P=0.531 |
|LOGISTIC REGRESSION | P=0.636N P=0.600 P=0.454N P=0.672 | P=0.221 (e) (e) P=0.531 |
|COCHRAN-ARMITAGE | P=0.513N | P=0.200 |
|FISHER EXACT | P=0.487 P=0.504N P=0.739 | (e) (e) P=0.504 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 2/60 (3%) 0/59 (0%) 0/59 (0%) | 0/59 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 5.6% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 2/36 (6%) 0/34 (0%) 0/17 (0%) | 0/36 (0%) 0/35 (0%) 0/41 (0%) 0/42 (0%) |
|FIRST INCIDENCE (DAYS) | --- 728 (T) --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.496N P=0.303 (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.496N P=0.303 (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.496N P=0.303 (e) (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.406N | (e) |
|FISHER EXACT | P=0.252 (e) (e) | (e) (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/59 (5%) 5/60 (8%) 2/59 (3%) 0/59 (0%) | 2/59 (3%) 0/60 (0%) 0/59 (0%) 0/60 (0%) |
|ADJUSTED (b) | 9.3% 12.9% 4.1% 0.0% | 3.9% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/27 (7%) 4/36 (11%) 0/34 (0%) 0/17 (0%) | 0/36 (0%) 0/35 (0%) 0/41 (0%) 0/42 (0%) |
|FIRST INCIDENCE (DAYS) | 636 621 486 --- | 258 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.104N P=0.476 P=0.446N P=0.227N | P=0.111N P=0.233N P=0.233N P=0.228N |
|INCIDENTAL TUMOR | P=0.057N P=0.411 P=0.524N P=0.163N | P=0.145N P=0.261N P=0.377N P=0.261N |
|LOGISTIC REGRESSION | P=0.072N P=0.383 P=0.499N P=0.193N | P=0.125N P=0.276N P=0.308N P=0.247N |
|COCHRAN-ARMITAGE | P=0.051N | P=0.114N |
|FISHER EXACT | P=0.368 P=0.500N P=0.122N | P=0.244N P=0.248N P=0.244N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/59 (3%) 2/60 (3%) 4/59 (7%) 3/59 (5%) | 0/59 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) |
|ADJUSTED (b) | 4.9% 4.6% 11.3% 12.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/36 (0%) 3/34 (9%) 0/17 (0%) | 0/36 (0%) 0/35 (0%) 0/41 (0%) 0/42 (0%) |
|FIRST INCIDENCE (DAYS) | 647 706 727 630 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.155 P=0.610N P=0.426 P=0.298 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.167 P=0.521 P=0.320 P=0.291 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.129 P=0.329 P=0.371 P=0.146 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.355 | (e) |
|FISHER EXACT | P=0.684N P=0.340 P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 40/59 (68%) 41/60 (68%) 44/59 (75%) 26/59 (44%) | 29/59 (49%) 30/60 (50%) 31/59 (53%) 29/60 (48%) |
|ADJUSTED (b) | 90.3% 81.7% 86.1% 85.1% | 66.8% 72.6% 62.6% 62.7% |
|TERMINAL (d) | 23/27 (85%) 27/36 (75%) 27/34 (79%) 13/17 (76%) | 22/36 (61%) 24/35 (69%) 23/41 (56%) 25/42 (60%) |
|FIRST INCIDENCE (DAYS) | 498 312 526 396 | 472 576 440 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.389 P=0.132N P=0.368N P=0.527 | P=0.187N P=0.461 P=0.463N P=0.276N |
|INCIDENTAL TUMOR | P=0.256N P=0.575N P=0.346 P=0.315N | P=0.270N P=0.501 P=0.526N P=0.335N |
|LOGISTIC REGRESSION | P=0.276N P=0.542 P=0.330 P=0.326N | P=0.335N P=0.550N P=0.556 P=0.366N |
|COCHRAN-ARMITAGE | P=0.003N** | P=0.500N |
|FISHER EXACT | P=0.553 P=0.271 P=0.008N** | P=0.536 P=0.427 P=0.537N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/59 (42%) 29/60 (48%) 35/59 (59%) 19/59 (32%) | 25/59 (42%) 26/60 (43%) 22/59 (37%) 12/60 (20%) |
|ADJUSTED (b) | 59.4% 61.9% 70.3% 58.8% | 53.9% 53.2% 46.4% 25.7% |
|TERMINAL (d) | 12/27 (44%) 19/36 (53%) 20/34 (59%) 5/17 (29%) | 15/36 (42%) 13/35 (37%) 16/41 (39%) 8/42 (19%) |
|FIRST INCIDENCE (DAYS) | 461 469 434 511 | 583 570 646 651 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.190 P=0.464N P=0.253 P=0.332 | P=0.001N** P=0.491 P=0.212N P=0.004N** |
|INCIDENTAL TUMOR | P=0.469N P=0.255 P=0.052 P=0.540N | P<0.001N** P=0.536N P=0.254N P=0.003N** |
|LOGISTIC REGRESSION | P=0.498 P=0.306 P=0.050 P=0.565 | P<0.001N** P=0.474N P=0.243N P=0.003N** |
|COCHRAN-ARMITAGE | P=0.132N | P=0.003N** |
|FISHER EXACT | P=0.320 P=0.049 * P=0.171N | P=0.532 P=0.354N P=0.007N** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 27/59 (46%) 31/60 (52%) 36/59 (61%) 20/59 (34%) | 25/59 (42%) 26/60 (43%) 22/59 (37%) 12/60 (20%) |
|ADJUSTED (b) | 61.4% 63.7% 71.1% 60.3% | 53.9% 53.2% 46.4% 25.7% |
|TERMINAL (d) | 12/27 (44%) 19/36 (53%) 20/34 (59%) 5/17 (29%) | 15/36 (42%) 13/35 (37%) 16/41 (39%) 8/42 (19%) |
|FIRST INCIDENCE (DAYS) | 461 469 434 511 | 583 570 646 651 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.223 P=0.439N P=0.321 P=0.351 | P=0.001N** P=0.491 P=0.212N P=0.004N** |
|INCIDENTAL TUMOR | P=0.422N P=0.206 P=0.062 P=0.500N | P<0.001N** P=0.536N P=0.254N P=0.003N** |
|LOGISTIC REGRESSION | P=0.524N P=0.307 P=0.072 P=0.569 | P<0.001N** P=0.474N P=0.243N P=0.003N** |
|COCHRAN-ARMITAGE | P=0.091N | P=0.003N** |
|FISHER EXACT | P=0.323 P=0.070 P=0.130N | P=0.532 P=0.354N P=0.007N** |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 47/59 (80%) 52/60 (87%) 54/59 (92%) 36/59 (61%) | 41/59 (69%) 44/60 (73%) 40/59 (68%) 36/60 (60%) |
|ADJUSTED (b) | 95.8% 92.9% 96.4% 94.4% | 83.6% 86.1% 78.1% 73.2% |
|TERMINAL (d) | 25/27 (93%) 32/36 (89%) 32/34 (94%) 15/17 (88%) | 28/36 (78%) 28/35 (80%) 30/41 (73%) 29/42 (69%) |
|FIRST INCIDENCE (DAYS) | 461 312 434 396 | 472 570 440 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.097 P=0.238N P=0.476N P=0.171 | P=0.016N* P=0.350 P=0.219N P=0.054N |
|INCIDENTAL TUMOR | P=0.510N P=0.125 P=0.065 P=0.479 | P=0.021N* P=0.441 P=0.246N P=0.049N* |
|LOGISTIC REGRESSION | P=0.504 P=0.117 P=0.052 P=0.402 | P=0.026N* P=0.504 P=0.299N P=0.061N |
|COCHRAN-ARMITAGE | P=0.003N** | P=0.099N |
|FISHER EXACT | P=0.219 P=0.057 P=0.022N* | P=0.397 P=0.500N P=0.186N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 48/59 (81%) 52/60 (87%) 54/59 (92%) 36/59 (61%) | 41/59 (69%) 44/60 (73%) 40/59 (68%) 36/60 (60%) |
|ADJUSTED (b) | 95.9% 92.9% 96.4% 94.4% | 83.6% 86.1% 78.1% 73.2% |
|TERMINAL (d) | 25/27 (93%) 32/36 (89%) 32/34 (94%) 15/17 (88%) | 28/36 (78%) 28/35 (80%) 30/41 (73%) 29/42 (69%) |
|FIRST INCIDENCE (DAYS) | 461 312 434 396 | 472 570 440 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120 P=0.192N P=0.414N P=0.206 | P=0.016N* P=0.350 P=0.219N P=0.054N |
|INCIDENTAL TUMOR | P=0.431N P=0.166 P=0.094 P=0.551 | P=0.021N* P=0.441 P=0.246N P=0.049N* |
|LOGISTIC REGRESSION | P=0.521N P=0.169 P=0.084 P=0.484 | P=0.026N* P=0.504 P=0.299N P=0.061N |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.099N |
|FISHER EXACT | P=0.295 P=0.089 P=0.012N* | P=0.397 P=0.500N P=0.186N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/60 (20%) 6/60 (10%) 6/60 (10%) 4/60 (7%) | 2/59 (3%) 3/60 (5%) 5/60 (8%) 1/60 (2%) |
|ADJUSTED (b) | 33.6% 16.7% 15.4% 15.3% | 4.7% 8.1% 10.7% 2.4% |
|TERMINAL (d) | 5/27 (19%) 6/36 (17%) 3/34 (9%) 2/17 (12%) | 1/36 (3%) 2/35 (6%) 2/41 (5%) 1/42 (2%) |
|FIRST INCIDENCE (DAYS) | 636 728 (T) 646 174 | 584 715 647 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.124N P=0.035N* P=0.051N P=0.163N | P=0.328N P=0.496 P=0.267 P=0.451N |
|INCIDENTAL TUMOR | P=0.065N P=0.103N P=0.128N P=0.062N | P=0.385N P=0.536 P=0.201 P=0.583N |
|LOGISTIC REGRESSION | P=0.067N P=0.059N P=0.075N P=0.066N | P=0.371N P=0.517 P=0.233 P=0.491N |
|COCHRAN-ARMITAGE | P=0.028N* | P=0.391N |
|FISHER EXACT | P=0.100N P=0.100N P=0.029N* | P=0.508 P=0.226 P=0.494N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 2/60 (3%) 3/60 (5%) 3/60 (5%) | 3/59 (5%) 2/60 (3%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 11.4% 4.8% 7.6% 8.7% | 8.0% 4.7% 1.8% 4.3% |
|TERMINAL (d) | 2/27 (7%) 1/36 (3%) 1/34 (3%) 0/17 (0%) | 2/36 (6%) 1/35 (3%) 0/41 (0%) 1/42 (2%) |
|FIRST INCIDENCE (DAYS) | 498 647 675 318 | 727 576 591 675 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.455 P=0.267N P=0.409N P=0.609 | P=0.342N P=0.505N P=0.263N P=0.432N |
|INCIDENTAL TUMOR | P=0.489N P=0.370N P=0.551N P=0.399N | P=0.473N P=0.464N P=0.342N P=0.442N |
|LOGISTIC REGRESSION | P=0.499N P=0.336N P=0.500N P=0.476N | P=0.394N P=0.483N P=0.290N P=0.453N |
|COCHRAN-ARMITAGE | P=0.500N | P=0.398N |
|FISHER EXACT | P=0.340N P=0.500N P=0.500N | P=0.492N P=0.303N P=0.492N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/60 (25%) 8/60 (13%) 9/60 (15%) 7/60 (12%) | 4/59 (7%) 5/60 (8%) 6/60 (10%) 3/60 (5%) |
|ADJUSTED (b) | 39.3% 21.2% 22.1% 22.6% | 9.9% 12.6% 12.4% 6.7% |
|TERMINAL (d) | 6/27 (22%) 7/36 (19%) 4/34 (12%) 2/17 (12%) | 2/36 (6%) 3/35 (9%) 2/41 (5%) 2/42 (5%) |
|FIRST INCIDENCE (DAYS) | 498 647 646 174 | 584 576 591 675 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.279N P=0.028N* P=0.063N P=0.276N | P=0.313N P=0.495 P=0.444 P=0.422N |
|INCIDENTAL TUMOR | P=0.107N P=0.098N P=0.181N P=0.058N | P=0.446N P=0.557 P=0.318 P=0.517N |
|LOGISTIC REGRESSION | P=0.108N P=0.071N P=0.110N P=0.074N | P=0.379N P=0.523 P=0.392 P=0.470N |
|COCHRAN-ARMITAGE | P=0.058N | P=0.393N |
|FISHER EXACT | P=0.082N P=0.127N P=0.049N* | P=0.511 P=0.382 P=0.491N |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/58 (3%) 0/58 (0%) 3/60 (5%) 3/59 (5%) |
|ADJUSTED (b) | | 4.6% 0.0% 6.9% 6.4% |
|TERMINAL (d) | | 1/35 (3%) 0/34 (0%) 2/41 (5%) 1/41 (2%) |
|FIRST INCIDENCE (DAYS) | | 331 --- 702 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.288 P=0.239N P=0.556 P=0.555 |
|INCIDENTAL TUMOR | | P=0.263 P=0.275N P=0.482 P=0.518 |
|LOGISTIC REGRESSION | | P=0.236 P=0.265N P=0.502 P=0.494 |
|COCHRAN-ARMITAGE | | P=0.240 |
|FISHER EXACT | | P=0.248N P=0.516 P=0.508 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/52 (0%) 1/57 (2%) 0/56 (0%) 0/53 (0%) | 11/56 (20%) 18/57 (32%) 15/60 (25%) 18/60 (30%) |
|ADJUSTED (b) | 0.0% 2.9% 0.0% 0.0% | 30.1% 44.8% 33.6% 39.7% |
|TERMINAL (d) | 0/26 (0%) 1/35 (3%) 0/32 (0%) 0/17 (0%) | 10/35 (29%) 13/34 (38%) 12/41 (29%) 15/42 (36%) |
|FIRST INCIDENCE (DAYS) | --- 728 (T) --- --- | 601 577 591 675 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.646N P=0.559 (e) (e) | P=0.358 P=0.089 P=0.408 P=0.225 |
|INCIDENTAL TUMOR | P=0.646N P=0.559 (e) (e) | P=0.262 P=0.142 P=0.370 P=0.202 |
|LOGISTIC REGRESSION | P=0.646N P=0.559 (e) (e) | P=0.296 P=0.119 P=0.382 P=0.206 |
|COCHRAN-ARMITAGE | P=0.569N | P=0.210 |
|FISHER EXACT | P=0.523 (e) (e) | P=0.108 P=0.320 P=0.142 |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 1.9% 1.9% 0.0% 0.0% | 0.0% 2.9% 0.0% 4.2% |
|TERMINAL (d) | 0/27 (0%) 0/36 (0%) 0/34 (0%) 0/17 (0%) | 0/36 (0%) 1/35 (3%) 0/41 (0%) 1/42 (2%) |
|FIRST INCIDENCE (DAYS) | 589 615 --- --- | --- 729 (T) --- 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.304N P=0.756 P=0.504N P=0.598N | P=0.170 P=0.494 (e) P=0.272 |
|INCIDENTAL TUMOR | P=0.189N P=0.659 P=0.500N P=0.455N | P=0.165 P=0.494 (e) P=0.267 |
|LOGISTIC REGRESSION | P=0.193N P=0.741N P=0.475N P=0.483N | P=0.146 P=0.494 (e) P=0.243 |
|COCHRAN-ARMITAGE | P=0.236N | P=0.140 |
|FISHER EXACT | P=0.752N P=0.500N P=0.500N | P=0.500 (e) P=0.248 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 5.6% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 2/36 (6%) 0/34 (0%) 0/17 (0%) | 0/36 (0%) 0/35 (0%) 0/41 (0%) 0/42 (0%) |
|FIRST INCIDENCE (DAYS) | --- 728 (T) --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.496N P=0.303 (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.496N P=0.303 (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.496N P=0.303 (e) (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.405N | (e) |
|FISHER EXACT | P=0.248 (e) (e) | (e) (e) (e) |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/59 (2%) 2/59 (3%) 1/59 (2%) 1/57 (2%) | 1/59 (2%) 1/60 (2%) 0/59 (0%) 1/59 (2%) |
|ADJUSTED (b) | 2.0% 4.7% 2.9% 5.9% | 2.8% 2.9% 0.0% 2.2% |
|TERMINAL (d) | 0/27 (0%) 1/36 (3%) 1/34 (3%) 1/17 (6%) | 1/36 (3%) 1/35 (3%) 0/41 (0%) 0/42 (0%) |
|FIRST INCIDENCE (DAYS) | 636 621 728 (T) 728 (T) | 729 (T) 729 (T) --- 707 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.563 P=0.528 P=0.740N P=0.636 | P=0.576N P=0.756 P=0.474N P=0.733N |
|INCIDENTAL TUMOR | P=0.569N P=0.423 P=0.751N P=0.737 | P=0.587N P=0.756 P=0.474N P=0.743N |
|LOGISTIC REGRESSION | P=0.626 P=0.503 P=0.762N P=0.687 | P=0.589N P=0.756 P=0.474N P=0.743N |
|COCHRAN-ARMITAGE | P=0.542N | P=0.617N |
|FISHER EXACT | P=0.500 P=0.752N P=0.743 | P=0.748N P=0.500N P=0.752N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/60 (3%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) 2/60 (3%) 2/60 (3%) |
|ADJUSTED (b) | 2.9% 5.0% 0.0% 0.0% | 0.0% 2.2% 4.9% 4.6% |
|TERMINAL (d) | 0/27 (0%) 1/36 (3%) 0/34 (0%) 0/17 (0%) | 0/36 (0%) 0/35 (0%) 2/41 (5%) 1/42 (2%) |
|FIRST INCIDENCE (DAYS) | 707 707 --- --- | --- 684 729 (T) 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.239N P=0.587 P=0.463N P=0.578N | P=0.201 P=0.513 P=0.267 P=0.273 |
|INCIDENTAL TUMOR | P=0.282N P=0.415 P=0.571N P=0.638N | P=0.192 P=0.517 P=0.267 P=0.267 |
|LOGISTIC REGRESSION | P=0.244N P=0.537 P=0.489N P=0.585N | P=0.185 P=0.504 P=0.267 P=0.267 |
|COCHRAN-ARMITAGE | P=0.188N | P=0.160 |
|FISHER EXACT | P=0.500 P=0.500N P=0.500N | P=0.500 P=0.248 P=0.248 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) 2/60 (3%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 5.0% 0.0% 0.0% | 0.0% 2.2% 4.9% 4.6% |
|TERMINAL (d) | 0/27 (0%) 1/36 (3%) 0/34 (0%) 0/17 (0%) | 0/36 (0%) 0/35 (0%) 2/41 (5%) 1/42 (2%) |
|FIRST INCIDENCE (DAYS) | --- 707 --- --- | --- 684 729 (T) 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.490N P=0.299 (e) (e) | P=0.201 P=0.513 P=0.267 P=0.273 |
|INCIDENTAL TUMOR | P=0.513N P=0.212 (e) (e) | P=0.192 P=0.517 P=0.267 P=0.267 |
|LOGISTIC REGRESSION | P=0.489N P=0.267 (e) (e) | P=0.185 P=0.504 P=0.267 P=0.267 |
|COCHRAN-ARMITAGE | P=0.405N | P=0.160 |
|FISHER EXACT | P=0.248 (e) (e) | P=0.500 P=0.248 P=0.248 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/59 (0%) 4/59 (7%) 1/57 (2%) | 2/58 (3%) 3/60 (5%) 2/59 (3%) 9/59 (15%) |
|ADJUSTED (b) | 3.6% 0.0% 10.1% 5.9% | 5.6% 8.6% 4.9% 19.6% |
|TERMINAL (d) | 0/27 (0%) 0/36 (0%) 2/34 (6%) 1/17 (6%) | 2/36 (6%) 3/35 (9%) 2/41 (5%) 6/42 (14%) |
|FIRST INCIDENCE (DAYS) | 727 --- 616 728 (T) | 729 (T) 729 (T) 729 (T) 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.269 P=0.434N P=0.247 P=0.656 | P=0.016 * P=0.487 P=0.647N P=0.052 |
|INCIDENTAL TUMOR | P=0.314 P=0.619N P=0.159 P=0.627 | P=0.013 * P=0.487 P=0.647N P=0.044 * |
|LOGISTIC REGRESSION | P=0.301 P=0.439N P=0.186 P=0.672 | P=0.011 * P=0.487 P=0.647N P=0.040 * |
|COCHRAN-ARMITAGE | P=0.426 | P=0.007 ** |
|FISHER EXACT | P=0.504N P=0.177 P=0.739 | P=0.516 P=0.684N P=0.028 * |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/59 (0%) 4/59 (7%) 2/57 (4%) | 2/58 (3%) 3/60 (5%) 2/59 (3%) 9/59 (15%) |
|ADJUSTED (b) | 3.6% 0.0% 10.1% 8.7% | 5.6% 8.6% 4.9% 19.6% |
|TERMINAL (d) | 0/27 (0%) 0/36 (0%) 2/34 (6%) 1/17 (6%) | 2/36 (6%) 3/35 (9%) 2/41 (5%) 6/42 (14%) |
|FIRST INCIDENCE (DAYS) | 727 --- 616 580 | 729 (T) 729 (T) 729 (T) 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.099 P=0.434N P=0.247 P=0.345 | P=0.016 * P=0.487 P=0.647N P=0.052 |
|INCIDENTAL TUMOR | P=0.162 P=0.619N P=0.159 P=0.395 | P=0.013 * P=0.487 P=0.647N P=0.044 * |
|LOGISTIC REGRESSION | P=0.144 P=0.439N P=0.186 P=0.386 | P=0.011 * P=0.487 P=0.647N P=0.040 * |
|COCHRAN-ARMITAGE | P=0.222 | P=0.007 ** |
|FISHER EXACT | P=0.504N P=0.177 P=0.481 | P=0.516 P=0.684N P=0.028 * |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/60 (2%) 0/60 (0%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | | 2.5% 0.0% 2.4% 4.4% |
|TERMINAL (d) | | 0/36 (0%) 0/35 (0%) 1/41 (2%) 1/42 (2%) |
|FIRST INCIDENCE (DAYS) | | 714 --- 729 (T) 687 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.290 P=0.505N P=0.738N P=0.546 |
|INCIDENTAL TUMOR | | P=0.279 P=0.483N P=0.746N P=0.538 |
|LOGISTIC REGRESSION | | P=0.270 P=0.492N P=0.742N P=0.527 |
|COCHRAN-ARMITAGE | | P=0.248 |
|FISHER EXACT | | P=0.500N P=0.752N P=0.500 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/60 (2%) 1/60 (2%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | | 2.5% 2.9% 2.4% 4.4% |
|TERMINAL (d) | | 0/36 (0%) 1/35 (3%) 1/41 (2%) 1/42 (2%) |
|FIRST INCIDENCE (DAYS) | | 714 729 (T) 729 (T) 687 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.405 P=0.754 P=0.738N P=0.546 |
|INCIDENTAL TUMOR | | P=0.395 P=0.754N P=0.746N P=0.538 |
|LOGISTIC REGRESSION | | P=0.384 P=0.755N P=0.742N P=0.527 |
|COCHRAN-ARMITAGE | | P=0.351 |
|FISHER EXACT | | P=0.752N P=0.752N P=0.500 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 6/60 (10%) 1/60 (2%) 1/60 (2%) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 3/60 (5%) |
|ADJUSTED (b) | 0.0% 15.1% 2.9% 4.3% | 0.0% 2.9% 0.0% 6.6% |
|TERMINAL (d) | 0/27 (0%) 4/36 (11%) 1/34 (3%) 0/17 (0%) | 0/36 (0%) 1/35 (3%) 0/41 (0%) 2/42 (5%) |
|FIRST INCIDENCE (DAYS) | --- 705 728 (T) 707 | --- 729 (T) --- 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.593N P=0.040 * P=0.546 P=0.422 | P=0.060 P=0.494 (e) P=0.153 |
|INCIDENTAL TUMOR | P=0.589 P=0.018 * P=0.546 P=0.362 | P=0.058 P=0.494 (e) P=0.147 |
|LOGISTIC REGRESSION | P=0.589N P=0.028 * P=0.546 P=0.415 | P=0.050 P=0.494 (e) P=0.133 |
|COCHRAN-ARMITAGE | P=0.404N | P=0.044 * |
|FISHER EXACT | P=0.014 * P=0.500 P=0.500 | P=0.500 (e) P=0.122 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 7/60 (12%) 3/60 (5%) 2/60 (3%) | 5/60 (8%) 2/60 (3%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 12.9% 17.7% 6.9% 11.8% | 11.9% 5.7% 2.2% 2.2% |
|TERMINAL (d) | 3/27 (11%) 5/36 (14%) 1/34 (3%) 2/17 (12%) | 3/36 (8%) 2/35 (6%) 0/41 (0%) 0/42 (0%) |
|FIRST INCIDENCE (DAYS) | 636 621 486 728 (T) | 258 729 (T) 707 707 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.331N P=0.410 P=0.419N P=0.576N | P=0.047N* P=0.225N P=0.089N P=0.085N |
|INCIDENTAL TUMOR | P=0.233N P=0.307 P=0.478N P=0.504N | P=0.055N P=0.252N P=0.122N P=0.100N |
|LOGISTIC REGRESSION | P=0.279N P=0.300 P=0.500N P=0.549N | P=0.062N P=0.224N P=0.113N P=0.112N |
|COCHRAN-ARMITAGE | P=0.147N | P=0.060N |
|FISHER EXACT | P=0.264 P=0.500N P=0.340N | P=0.219N P=0.103N P=0.103N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 13/60 (22%) 4/60 (7%) 3/60 (5%) | 5/60 (8%) 3/60 (5%) 1/60 (2%) 4/60 (7%) |
|ADJUSTED (b) | 12.9% 31.6% 9.8% 15.6% | 11.9% 8.6% 2.2% 8.7% |
|TERMINAL (d) | 3/27 (11%) 9/36 (25%) 2/34 (6%) 2/17 (12%) | 3/36 (8%) 3/35 (9%) 0/41 (0%) 2/42 (5%) |
|FIRST INCIDENCE (DAYS) | 636 621 486 707 | 258 729 (T) 707 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.349N P=0.062 P=0.551N P=0.559 | P=0.366N P=0.365N P=0.089N P=0.424N |
|INCIDENTAL TUMOR | P=0.279N P=0.023 * P=0.607N P=0.602 | P=0.395N P=0.398N P=0.122N P=0.464N |
|LOGISTIC REGRESSION | P=0.308N P=0.027 * P=0.641N P=0.582 | P=0.439N P=0.360N P=0.113N P=0.507N |
|COCHRAN-ARMITAGE | P=0.122N | P=0.443N |
|FISHER EXACT | P=0.017 * P=0.641N P=0.500N | P=0.359N P=0.103N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 2/60 (3%) 0/60 (0%) | 3/60 (5%) 1/60 (2%) 0/60 (0%) 3/60 (5%) |
|ADJUSTED (b) | 7.0% 2.8% 4.7% 0.0% | 7.2% 2.2% 0.0% 6.6% |
|TERMINAL (d) | 1/27 (4%) 1/36 (3%) 1/34 (3%) 0/17 (0%) | 1/36 (3%) 0/35 (0%) 0/41 (0%) 2/42 (5%) |
|FIRST INCIDENCE (DAYS) | 709 728 (T) 580 --- | 583 696 --- 651 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.288N P=0.391N P=0.622N P=0.329N | P=0.583 P=0.308N P=0.105N P=0.594N |
|INCIDENTAL TUMOR | P=0.264N P=0.492N P=0.684N P=0.373N | P=0.505 P=0.259N P=0.154N P=0.636 |
|LOGISTIC REGRESSION | P=0.265N P=0.428N P=0.693N P=0.336N | P=0.537 P=0.299N P=0.118N P=0.648N |
|COCHRAN-ARMITAGE | P=0.200N | P=0.526 |
|FISHER EXACT | P=0.500N P=0.691N P=0.248N | P=0.309N P=0.122N P=0.660N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 3/60 (5%) 6/60 (10%) 2/60 (3%) | 20/60 (33%) 23/60 (38%) 21/60 (35%) 17/60 (28%) |
|ADJUSTED (b) | 23.7% 7.6% 14.1% 6.9% | 44.1% 54.0% 46.2% 35.5% |
|TERMINAL (d) | 3/27 (11%) 2/36 (6%) 2/34 (6%) 0/17 (0%) | 12/36 (33%) 16/35 (46%) 17/41 (41%) 12/42 (29%) |
|FIRST INCIDENCE (DAYS) | 486 702 580 625 | 469 504 646 595 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.138N P=0.033N* P=0.211N P=0.133N | P=0.096N P=0.345 P=0.472N P=0.201N |
|INCIDENTAL TUMOR | P=0.085N P=0.104N P=0.352N P=0.078N | P=0.148N P=0.317 P=0.530N P=0.342N |
|LOGISTIC REGRESSION | P=0.075N P=0.065N P=0.291N P=0.068N | P=0.163N P=0.403 P=0.575N P=0.292N |
|COCHRAN-ARMITAGE | P=0.041N* | P=0.237N |
|FISHER EXACT | P=0.063N P=0.291N P=0.027N* | P=0.352 P=0.500 P=0.346N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 2/60 (3%) 5/60 (8%) 2/60 (3%) | 17/60 (28%) 22/60 (37%) 21/60 (35%) 14/60 (23%) |
|ADJUSTED (b) | 17.7% 4.9% 12.5% 6.9% | 38.9% 53.0% 46.2% 29.9% |
|TERMINAL (d) | 2/27 (7%) 1/36 (3%) 2/34 (6%) 0/17 (0%) | 11/36 (31%) 16/35 (46%) 17/41 (41%) 10/42 (24%) |
|FIRST INCIDENCE (DAYS) | 486 702 622 625 | 469 504 646 595 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.270N P=0.054N P=0.300N P=0.251N | P=0.084N P=0.214 P=0.442 P=0.205N |
|INCIDENTAL TUMOR | P=0.186N P=0.142N P=0.448N P=0.151N | P=0.123N P=0.169 P=0.412 P=0.320N |
|LOGISTIC REGRESSION | P=0.171N P=0.083N P=0.380N P=0.138N | P=0.141N P=0.256 P=0.347 P=0.289N |
|COCHRAN-ARMITAGE | P=0.110N | P=0.211N |
|FISHER EXACT | P=0.081N P=0.381N P=0.081N | P=0.218 P=0.278 P=0.339N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 47/60 (78%) 49/60 (82%) 50/60 (83%) 31/60 (52%) | 38/60 (63%) 40/60 (67%) 44/60 (73%) 45/60 (75%) |
|ADJUSTED (b) | 93.7% 94.2% 94.3% 90.1% | 84.1% 84.8% 82.8% 88.2% |
|TERMINAL (d) | 24/27 (89%) 33/36 (92%) 31/34 (91%) 14/17 (82%) | 29/36 (81%) 28/35 (80%) 32/41 (78%) 36/42 (86%) |
|FIRST INCIDENCE (DAYS) | 461 312 526 174 | 331 576 79 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.380 P=0.122N P=0.271N P=0.494 | P=0.523 P=0.393 P=0.487 P=0.507 |
|INCIDENTAL TUMOR | P=0.138N P=0.371 P=0.358 P=0.152N | P=0.233 P=0.461 P=0.301 P=0.328 |
|LOGISTIC REGRESSION | P=0.164N P=0.319 P=0.353 P=0.188N | P=0.205 P=0.558 P=0.242 P=0.267 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.081 |
|FISHER EXACT | P=0.410 P=0.322 P=0.002N** | P=0.424 P=0.163 P=0.118 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 41/60 (68%) 40/60 (67%) 43/60 (72%) 27/60 (45%) | 41/60 (68%) 45/60 (75%) 40/60 (67%) 31/60 (52%) |
|ADJUSTED (b) | 80.9% 75.0% 76.4% 70.3% | 78.5% 81.8% 76.9% 57.2% |
|TERMINAL (d) | 18/27 (67%) 23/36 (64%) 21/34 (62%) 6/17 (35%) | 25/36 (69%) 25/35 (71%) 29/41 (71%) 19/42 (45%) |
|FIRST INCIDENCE (DAYS) | 461 210 434 318 | 258 504 591 595 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.390 P=0.135N P=0.343N P=0.504 | P=0.004N** P=0.326 P=0.238N P=0.021N* |
|INCIDENTAL TUMOR | P=0.072N P=0.456 P=0.330 P=0.150N | P=0.004N** P=0.343 P=0.354N P=0.034N* |
|LOGISTIC REGRESSION | P=0.103N P=0.533N P=0.423 P=0.219N | P=0.004N** P=0.353 P=0.357N P=0.026N* |
|COCHRAN-ARMITAGE | P=0.004N** | P=0.012N* |
|FISHER EXACT | P=0.500N P=0.421 P=0.008N** | P=0.272 P=0.500N P=0.047N* |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 04 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.5% 1.0% 2.0% | VEHICLE 0.5% 1.0% 2.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 56/60 (93%) 56/60 (93%) 56/60 (93%) 43/60 (72%) | 54/60 (90%) 54/60 (90%) 55/60 (92%) 53/60 (88%) |
|ADJUSTED (b) | 100.0% 98.2% 98.2% 97.7% | 96.4% 96.4% 98.2% 94.6% |
|TERMINAL (d) | 27/27 (100%) 35/36 (97%) 33/34 (97%) 16/17 (94%) | 34/36 (94%) 33/35 (94%) 40/41 (98%) 39/42 (93%) |
|FIRST INCIDENCE (DAYS) | 461 210 434 174 | 258 504 79 595 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.084 P=0.061N P=0.134N P=0.156 | P=0.060N P=0.538 P=0.247N P=0.111N |
|INCIDENTAL TUMOR | P=0.196N P=0.466 P=0.666N P=0.470N | P=0.156N P=0.477N P=0.544N P=0.245N |
|LOGISTIC REGRESSION | P=0.280N P=0.315 P=0.661 P=0.615N | P=0.281N P=0.387N P=0.629N P=0.282N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.442N |
|FISHER EXACT | P=0.641N P=0.641N P=0.002N** | P=0.619N P=0.500 P=0.500N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).