TDMS Study 05142-04 Pathology Tables
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
Facility: Southern Research Institute
Chemical CAS #: 75-65-0
Lock Date: 01/23/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7|
DAY ON TEST | 3| 3| 3| 9| 5| 3| 1| 7| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3|
| 5| 5| 5| 0| 9| 5| 4| 2| 5| 5| 1| 5| 3| 5| 5| 0| 0| 5| 5| 5| 7| 5| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + A +|
Basophilic Focus | X X |
Eosinophilic Focus | X X X X X X X |
Fatty Change | 2 4 1 3 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Infarct | 3 |
Inflammation, Focal | 1 1 |
Mineralization, Focal | |
Mixed Cell Focus | X |
Necrosis, Focal | |
Pigmentation | |
Thrombosis | |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 2 |
Fat, Necrosis | 2 2 2 2 3 3 3 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +|
Atrophy, Focal | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | 3 |
Ulcer | 2 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7|
DAY ON TEST | 3| 3| 3| 9| 5| 3| 1| 7| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3|
| 5| 5| 5| 0| 9| 5| 4| 2| 5| 5| 1| 5| 3| 5| 5| 0| 0| 5| 5| 5| 7| 5| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Parathyroid Gland | + + M + M + M + + + + + + + + M M + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + M + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Focal Cellular Change | 2 1 |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
Degeneration, Cystic | 1 1 1 |
Inflammation, Focal | 2 |
C-Cell, Hyperplasia | 1 1 |
Follicular Cell, Hyperplasia | 3 4 2 2 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Degeneration, Cystic | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + A +|
Angiectasis | 2 |
Hemorrhage | |
Necrosis | |
Thrombosis | |
Follicle, Cyst | 3 3 2 1 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Exudate | 3 |
Hemorrhage | |
Hydrometra | 2 2 2 2 3 3 4 4 |
Inflammation, Suppurative | 1 |
Endometrium, Hyperplasia, Cystic | 4 3 4 3 3 4 4 3 4 3 4 4 4 4 4 4 3 4 4 4 3 2 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +|
Angiectasis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Bronchial, Hyperplasia, Lymphoid | 2 |
Iliac, Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7|
DAY ON TEST | 3| 3| 3| 9| 5| 3| 1| 7| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3|
| 5| 5| 5| 0| 9| 5| 4| 2| 5| 5| 1| 5| 3| 5| 5| 0| 0| 5| 5| 5| 7| 5| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hematopoietic Cell | |
Proliferation | 2 |
Iliac, Hyperplasia | 2 |
Mediastinal, Angiectasis | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Renal, Hematopoietic Cell | |
Proliferation | 2 |
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia, Lymphoid | 2 2 2 2 2|
Hyperplasia, Macrophage | |
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +|
Depletion Cellular | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 4 2 3 2 1 3 2 1 |
Hyperplasia, Lymphoid | 2 2 2 2 2 3 2|
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + M + + + A +|
Congestion | 2 |
Cyst | 1 |
Hyperplasia, Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Epidermis, Hyperplasia, Focal | |
Sebaceous Gland, Hyperplasia | |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 1 1 2 1 2 2 1 2 1 1 1 2|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7|
DAY ON TEST | 3| 3| 3| 9| 5| 3| 1| 7| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3|
| 5| 5| 5| 0| 9| 5| 4| 2| 5| 5| 1| 5| 3| 5| 5| 0| 0| 5| 5| 5| 7| 5| 9| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + A +|
Congestion | |
Hemorrhage | |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +|
Nephropathy | 1 1 1 1 1 1 2 1 2 1 1 2 1 1 2 1 1 1|
Renal Tubule, Degeneration, Hyaline | |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 3| 7| 7|
DAY ON TEST | 6| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 2| 3| 3| 3| 3| 3| 4| 6| 3| 3| 3|
| 8| 6| 5| 5| 5| 0| 0| 0| 0| 9| 0| 5| 5| 5| 7| 5| 5| 5| 5| 5| 7| 9| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Eosinophilic Focus | X X X X|
Fatty Change | 3 2 3 |
Fibrosis, Focal | 1 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Infarct | |
Inflammation, Focal | 2 1 |
Mineralization, Focal | 1 |
Mixed Cell Focus | |
Necrosis, Focal | 2 |
Pigmentation | 1 |
Thrombosis | 4 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Hemorrhage | 2 |
Inflammation, Chronic | |
Fat, Necrosis | 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Chronic | 1 1 |
Ulcer | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 3| 7| 7|
DAY ON TEST | 6| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 2| 3| 3| 3| 3| 3| 4| 6| 3| 3| 3|
| 8| 6| 5| 5| 5| 0| 0| 0| 0| 9| 0| 5| 5| 5| 7| 5| 5| 5| 5| 5| 7| 9| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + M + + + + M + M + + + + + M + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Focal Cellular Change | 1 1 1 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1|
Inflammation, Focal | |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 1 1 2 3 3 1 1 2 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Degeneration, Cystic | |
__________________________________________________________________________|
Ovary | + + + + I + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | 3 4 2 |
Necrosis | 4 |
Thrombosis | 3 |
Follicle, Cyst | 4 4 2 4 2 2 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | 3 |
Exudate | |
Hemorrhage | 2 |
Hydrometra | 2 2 3 3 2 2 2 4 4 3 2|
Inflammation, Suppurative | 3 2 |
Endometrium, Hyperplasia, Cystic | 3 4 3 3 4 4 4 3 2 3 4 4 4 4 4 4 4 4 3 4 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Bronchial, Hyperplasia, Lymphoid | |
Iliac, Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 3| 7| 7|
DAY ON TEST | 6| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 2| 3| 3| 3| 3| 3| 4| 6| 3| 3| 3|
| 8| 6| 5| 5| 5| 0| 0| 0| 0| 9| 0| 5| 5| 5| 7| 5| 5| 5| 5| 5| 7| 9| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hyperplasia | |
Mediastinal, Angiectasis | |
Mediastinal, Hyperplasia, Lymphoid | 2 2 |
Renal, Hematopoietic Cell | |
Proliferation | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + M + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | 2 2 2 |
Hyperplasia, Macrophage | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 3 1 3 2 3 3 3 3 2|
Hyperplasia, Lymphoid | 2 2 3 2 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 1 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Epidermis, Hyperplasia, Focal | 2 |
Sebaceous Gland, Hyperplasia | 2 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3 1 2 2 1 2 1 2 3 1 2 1 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 3| 7| 7|
DAY ON TEST | 6| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 2| 3| 3| 3| 3| 3| 4| 6| 3| 3| 3|
| 8| 6| 5| 5| 5| 0| 0| 0| 0| 9| 0| 5| 5| 5| 7| 5| 5| 5| 5| 5| 7| 9| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 3 2 1 1 1 2 1 1 1 1 1|
Renal Tubule, Degeneration, Hyaline | |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 5| 7| 1| 2| 7| 6| 7| 7| 7| 5| | |
DAY ON TEST | 8| 3| 7| 5| 0| 5| 3| 3| 0| 8| | |
| 4| 5| 0| 8| 7| 3| 5| 5| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
VEHICLE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + M | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Basophilic Focus | | 3 |
Eosinophilic Focus | X X | 13 |
Fatty Change | 4 2 2 2 | 11 2.5|
Fibrosis, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Infarct | | 1 3.0|
Inflammation, Focal | 1 | 5 1.2|
Mineralization, Focal | | 1 1.0|
Mixed Cell Focus | X | 2 |
Necrosis, Focal | 3 | 2 2.5|
Pigmentation | | 1 1.0|
Thrombosis | | 1 4.0|
Centrilobular, Necrosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 24 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 2 | 2 2.0|
Fat, Necrosis | 2 2 | 14 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy, Focal | | 3 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Erosion | | 1 1.0|
Inflammation, Chronic | 2 | 4 1.8|
Ulcer | 2 | 2 2.0|
Mucosa, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Pigmentation | 1 | 1 1.0|
Mucosa, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Tooth | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 5| 7| 1| 2| 7| 6| 7| 7| 7| 5| | |
DAY ON TEST | 8| 3| 7| 5| 0| 5| 3| 3| 0| 8| | |
| 4| 5| 0| 8| 7| 3| 5| 5| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
VEHICLE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Incisor, Dysplasia | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Focal Cellular Change | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + | 56 |
Angiectasis | | 1 2.0|
Pars Distalis, Focal Cellular Change | 1 | 6 1.2|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
Degeneration, Cystic | 1 1 1 | 8 1.1|
Inflammation, Focal | | 1 2.0|
C-Cell, Hyperplasia | | 2 1.0|
Follicular Cell, Hyperplasia | 1 | 19 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Degeneration, Cystic | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Angiectasis | | 1 2.0|
Hemorrhage | | 3 3.0|
Necrosis | | 1 4.0|
Thrombosis | | 1 3.0|
Follicle, Cyst | 1 2 4 | 15 2.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Atrophy | | 1 3.0|
Exudate | | 1 3.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 5| 7| 1| 2| 7| 6| 7| 7| 7| 5| | |
DAY ON TEST | 8| 3| 7| 5| 0| 5| 3| 3| 0| 8| | |
| 4| 5| 0| 8| 7| 3| 5| 5| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
VEHICLE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hydrometra | 3 | 20 2.7|
Inflammation, Suppurative | 2 | 4 2.0|
Endometrium, Hyperplasia, Cystic | 3 4 3 3 3 3 3 4 3 2 | 58 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 19 |
Bronchial, Hyperplasia, Lymphoid | | 1 2.0|
Iliac, Angiectasis | | 1 3.0|
Iliac, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Iliac, Hyperplasia | | 1 2.0|
Mediastinal, Angiectasis | 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 3 2.0|
Renal, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 8 2.0|
Hyperplasia, Macrophage | 2 | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Depletion Cellular | 2 | 3 2.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 3 3 1 4 | 27 2.4|
Hyperplasia, Lymphoid | 3 | 15 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
Congestion | | 1 2.0|
Cyst | | 2 1.0|
Hyperplasia, Lymphoid | | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 5| 7| 1| 2| 7| 6| 7| 7| 7| 5| | |
DAY ON TEST | 8| 3| 7| 5| 0| 5| 3| 3| 0| 8| | |
| 4| 5| 0| 8| 7| 3| 5| 5| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
VEHICLE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Epidermis, Hyperplasia, Focal | | 1 2.0|
Sebaceous Gland, Hyperplasia | | 1 2.0|
Subcutaneous Tissue, Edema | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | 2 2 | 30 1.6|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 1 2.0|
Hemorrhage | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Congestion | | 1 3.0|
Hemorrhage | 1 | 1 1.0|
Hyperplasia, Macrophage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Nephropathy | 2 1 1 1 | 40 1.2|
Renal Tubule, Degeneration, Hyaline | 4 | 1 4.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 2| 3| 1| 3| 3| 9| 3| 3| 0| 0| 1| 3| 5| 3| 3| 7| 3| 3| 3| 3| 3| 3|
| 5| 0| 5| 4| 5| 5| 5| 5| 6| 5| 3| 9| 4| 0| 5| 0| 5| 5| 7| 5| 5| 5| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + A + + + + + +|
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X X X |
Fatty Change | 2 2 2 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | |
Infarct | |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 1 2 |
Mixed Cell Focus | X X X |
Necrosis, Focal | 2 |
Pigmentation | 2 |
Tension Lipidosis | |
Centrilobular, Atrophy | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Hemorrhage | |
Inflammation, Chronic | |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Acinar Cell, Focal Cellular Change | |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | 2 |
Mucosa, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Tooth | |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 2| 3| 1| 3| 3| 9| 3| 3| 0| 0| 1| 3| 5| 3| 3| 7| 3| 3| 3| 3| 3| 3|
| 5| 0| 5| 4| 5| 5| 5| 5| 6| 5| 3| 9| 4| 0| 5| 0| 5| 5| 7| 5| 5| 5| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Subcapsular, Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + I + + M + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Angiectasis | 2 2 |
Cyst | 1 |
Pars Distalis, Focal Cellular Change | 1 2 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Follicle, Cyst | 2 |
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | 1 2 2 1 2 2 1 2 2 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Degeneration, Cystic | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + M + + + + + + +|
Angiectasis | 2 |
Hemorrhage | 4 |
Follicle, Cyst | 2 2 4 2 4 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Decidual Reaction | |
Hydrometra | 4 3 3 3 2 3 3 4 2 3 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 4 3 4 3 3 3 3 3 3 4 3 4 4 3 3 3 4 3 3 4|
Lymphatic, Ectasia | |
__________________________________________________________________________|
Vagina | |
Epithelium, Metaplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 2| 3| 1| 3| 3| 9| 3| 3| 0| 0| 1| 3| 5| 3| 3| 7| 3| 3| 3| 3| 3| 3|
| 5| 0| 5| 4| 5| 5| 5| 5| 6| 5| 3| 9| 4| 0| 5| 0| 5| 5| 7| 5| 5| 5| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hyperplasia | 2 |
Mediastinal, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + M + +|
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Hematopoietic Cell Proliferation | 4 3 2 3 2 2 2 4 1 3 2 2 3 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2 1|
Hyperostosis | 1 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 2| 3| 1| 3| 3| 9| 3| 3| 0| 0| 1| 3| 5| 3| 3| 7| 3| 3| 3| 3| 3| 3|
| 5| 0| 5| 4| 5| 5| 5| 5| 6| 5| 3| 9| 4| 0| 5| 0| 5| 5| 7| 5| 5| 5| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | |
Pinna, Inflammation, Chronic, Focal | |
Pinna, Ulcer | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 2 1 2 1 1 1 1 2 1 1 3 1 2 1 2 1 2 2 2 1|
Pelvis, Dilatation | |
Renal Tubule, Vacuolization | |
Cytoplasmic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 3| 3| 7| 0| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 9| 3| 1| 1| 1| 6| 3| 7| 7| 3| 2| 7| 2| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3|
| 4| 4| 6| 4| 6| 0| 0| 5| 4| 2| 4| 4| 8| 6| 7| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + A + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X X |
Fatty Change | 2 3 2 2 2 |
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 2 |
Infarct | 3 3 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | |
Mixed Cell Focus | X X |
Necrosis, Focal | |
Pigmentation | 3 2 |
Tension Lipidosis | X |
Centrilobular, Atrophy | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Hemorrhage | 1 |
Inflammation, Chronic | 2 2 |
Fat, Necrosis | 2 3 3 3 2 |
__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 |
Acinar Cell, Focal Cellular Change | 1 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | 2 |
Mucosa, Hyperplasia | 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 3| 3| 7| 0| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 9| 3| 1| 1| 1| 6| 3| 7| 7| 3| 2| 7| 2| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3|
| 4| 4| 6| 4| 6| 0| 0| 5| 4| 2| 4| 4| 8| 6| 7| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Subcapsular, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Pars Distalis, Focal Cellular Change | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 2 1 2 2 |
Follicle, Cyst | |
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | 4 1 1 1 1 4 2 1 2 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Degeneration, Cystic | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | |
Hemorrhage | |
Follicle, Cyst | 3 3 2 3 3 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Decidual Reaction | 2 |
Hydrometra | 3 3 4 3 3 4 3 3 4|
Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic | 2 4 3 4 3 3 3 3 4 3 3 3 3 3 4 3 3 4 3 3 4 3 3 3|
Lymphatic, Ectasia | 4 |
__________________________________________________________________________|
Vagina | + |
Epithelium, Metaplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 3| 3| 7| 0| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 9| 3| 1| 1| 1| 6| 3| 7| 7| 3| 2| 7| 2| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3|
| 4| 4| 6| 4| 6| 0| 0| 5| 4| 2| 4| 4| 8| 6| 7| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Hyperplasia | |
Mediastinal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 1 |
Hematopoietic Cell Proliferation | 3 2 4 3 3 2 4 |
Hyperplasia, Lymphoid | 2 3 2 2 2|
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 |
Subcutaneous Tissue, Edema | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 1 2 1 1 1 1 1 2 1|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Macrophage | 2 |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 3| 3| 7| 0| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 9| 3| 1| 1| 1| 6| 3| 7| 7| 3| 2| 7| 2| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3|
| 4| 4| 6| 4| 6| 0| 0| 5| 4| 2| 4| 4| 8| 6| 7| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Inflammation, Chronic, Focal | 3 |
Pinna, Ulcer | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 2 2 2 1 1 1 2 1 1 1|
Pelvis, Dilatation | 2 |
Renal Tubule, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 59 |
Mucosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + | 57 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 1 |
Clear Cell Focus | X | 5 |
Eosinophilic Focus | X X | 14 |
Fatty Change | | 8 2.1|
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Infarct | | 2 3.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Focal | | 2 1.5|
Mixed Cell Focus | | 5 |
Necrosis, Focal | | 1 2.0|
Pigmentation | | 3 2.3|
Tension Lipidosis | | 1 |
Centrilobular, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 17 |
Hemorrhage | | 1 1.0|
Inflammation, Chronic | | 2 2.0|
Fat, Necrosis | 2 2 3 | 10 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy, Focal | | 3 2.0|
Acinar Cell, Focal Cellular Change | | 1 1.0|
Duct, Dilatation | | 2 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
Inflammation, Chronic | | 2 2.0|
Mucosa, Hyperplasia | 2 | 5 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Incisor, Dysplasia | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Mineralization, Focal | | 1 2.0|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Subcapsular, Hyperplasia, Focal | | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + | 57 |
Angiectasis | | 2 2.0|
Cyst | | 1 1.0|
Pars Distalis, Focal Cellular Change | 2 | 6 1.7|
Pars Distalis, Hyperplasia, Focal | | 5 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 | 9 1.6|
Follicle, Cyst | | 1 2.0|
Follicular Cell, Cyst | 3 | 1 3.0|
Follicular Cell, Hyperplasia | 3 2 1 2 3 2 | 28 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 2 |
Degeneration, Cystic | | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Angiectasis | 3 | 2 2.5|
Hemorrhage | | 1 4.0|
Follicle, Cyst | | 13 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Angiectasis | 2 | 2 2.5|
Decidual Reaction | | 1 2.0|
Hydrometra | 3 3 3 3 3 3 | 25 3.1|
Inflammation, Suppurative | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 3 3 | 59 3.2|
Lymphatic, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
Epithelium, Metaplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 12 |
Iliac, Hyperplasia | | 1 2.0|
Mediastinal, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 10 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Depletion Cellular | | 2 1.5|
Hematopoietic Cell Proliferation | 2 3 3 2 | 25 2.7|
Hyperplasia, Lymphoid | 2 2 3 | 18 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 5 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | | 4 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 3.0|
Subcutaneous Tissue, Edema | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | 1 2 1 2 2 2 | 34 1.6|
Hyperostosis | | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 3 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 2.5|
Hyperplasia, Macrophage | | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Inflammation, Chronic, Focal | | 1 3.0|
Pinna, Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | 3 | 1 3.0|
Nephropathy | 1 2 1 2 1 | 37 1.4|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 0| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3|
| 0| 7| 4| 4| 4| 0| 6| 4| 4| 4| 4| 4| 4| 4| 6| 3| 7| 7| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + A + + + + + + + + +|
Inflammation, Chronic | |
Perforation | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + A + + + + + + + + +|
Developmental Malformation | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + M + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + A + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X X|
Eosinophilic Focus | X X X X X X X X|
Fatty Change | 1 2 3 3 |
Fibrosis, Focal | 3 |
Hemorrhage | 3 |
Infarct | 3 |
Inflammation, Focal | 1 1 |
Mixed Cell Focus | X X |
Necrosis, Focal | 4 |
Necrosis | 1 |
Pigmentation | 1 |
Tension Lipidosis | |
Bile Duct, Hyperplasia | |
Centrilobular, Fibrosis | |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Cyst | 2 |
Inflammation, Chronic | |
Fat, Necrosis | 2 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
Duct, Dilatation | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | |
Mineralization | |
Ulcer | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 0| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3|
| 0| 7| 4| 4| 4| 0| 6| 4| 4| 4| 4| 4| 4| 4| 6| 3| 7| 7| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 |
Mineralization | |
Pigmentation | |
Ulcer | |
__________________________________________________________________________|
Tooth | |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Bacterium | 3 |
Aorta, Inflammation, Focal, | |
Suppurative | 3 |
Aorta, Thrombosis | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + M + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Focal Cellular Change | 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 2 |
Follicle, Cyst | |
Follicular Cell, Cyst | 1 |
Follicular Cell, Hyperplasia | 3 1 1 3 2 1 2 2 3 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + |
Degeneration, Cystic | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | 4 |
Follicle, Cyst | 4 4 3 2 3 4|
__________________________________________________________________________|
Uterus | + + + + + A + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 0| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3|
| 0| 7| 4| 4| 4| 0| 6| 4| 4| 4| 4| 4| 4| 4| 6| 3| 7| 7| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Angiectasis | 1 |
Hydrometra | 4 3 3 3 3 3 3|
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 3 3 3 4 4 3 3 4 4 3 3 4 3 3 3 3 3 3 3 4 4 3 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + A + + + + + + + + M + + + + + + + + + +|
Angiectasis | 4 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 2 3 4 2 1 3 3 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + A + + + + + + + + + M + + + + M + + + M|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Ulcer | 1 |
Subcutaneous Tissue, Hyperplasia, | |
Mast Cell | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 2 2 2 2 2 2 1 1 1 2 2 2 1 |
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Macrophage | 3 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 0| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3|
| 0| 7| 4| 4| 4| 0| 6| 4| 4| 4| 4| 4| 4| 4| 6| 3| 7| 7| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
Nephropathy | 1 1 3 1 2 1 1 1 1 2 1 1 1|
Pelvis, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 4| 3| 4| 3| 9| 3| 3| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0|
| 4| 6| 4| 0| 4| 1| 4| 4| 8| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Perforation | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Eosinophilic Focus | X X X X X|
Fatty Change | 2 1 2|
Fibrosis, Focal | |
Hemorrhage | |
Infarct | 3 |
Inflammation, Focal | 2 2 2 2 2 |
Mixed Cell Focus | X X X |
Necrosis, Focal | 2 |
Necrosis | |
Pigmentation | 2 |
Tension Lipidosis | |
Bile Duct, Hyperplasia | |
Centrilobular, Fibrosis | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Cyst | |
Inflammation, Chronic | |
Fat, Necrosis | 2 2 2 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Chronic | |
Mineralization | 1 |
Ulcer | |
Mucosa, Hyperplasia | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 4| 3| 4| 3| 9| 3| 3| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0|
| 4| 6| 4| 0| 4| 1| 4| 4| 8| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Mineralization | 1 |
Pigmentation | 2 |
Ulcer | |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Bacterium | |
Aorta, Inflammation, Focal, | |
Suppurative | |
Aorta, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Pars Distalis, Focal Cellular Change | 2 2 1|
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 2 2 |
Follicle, Cyst | 2 |
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | 2 1 2 2 2 1 2 1 1 1 1 1 2 1 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Degeneration, Cystic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | 4 |
Follicle, Cyst | 4 2 1 4 4 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 4| 3| 4| 3| 9| 3| 3| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0|
| 4| 6| 4| 0| 4| 1| 4| 4| 8| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Angiectasis | |
Hydrometra | 3 3 3 2 3 3 3 3 3 |
Inflammation, Suppurative | 3|
Endometrium, Hyperplasia, Cystic | 4 2 4 3 4 3 3 3 4 3 4 3 3 4 4 3 4 3 3 3 4 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 2 3 4 2 2 3 1 |
Hyperplasia, Lymphoid | 2 3 3 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + M + + + + + M + + M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
Ulcer | |
Subcutaneous Tissue, Hyperplasia, | |
Mast Cell | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 1 1 1 2 1 2 2 2 2 2 1 2 2 |
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 3 4 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Macrophage | 2 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 4| 3| 4| 3| 9| 3| 3| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0|
| 4| 6| 4| 0| 4| 1| 4| 4| 8| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 |
Nephropathy | 2 2 2 2 1 2 2 1 1 2 1 2 1 1 1 1 2|
Pelvis, Dilatation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 0| 8| 3| 0| 2| 3| 3| 3| | |
| 4| 5| 2| 8| 4| 2| 7| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
Inflammation, Chronic | 3 | 1 3.0|
Perforation | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
Developmental Malformation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Clear Cell Focus | | 3 |
Eosinophilic Focus | X X X | 16 |
Fatty Change | 2 | 8 2.0|
Fibrosis, Focal | | 1 3.0|
Hemorrhage | | 1 3.0|
Infarct | | 2 3.0|
Inflammation, Focal | | 7 1.7|
Mixed Cell Focus | X X | 7 |
Necrosis, Focal | | 2 3.0|
Necrosis | | 1 1.0|
Pigmentation | 2 | 3 1.7|
Tension Lipidosis | X | 1 |
Bile Duct, Hyperplasia | 2 | 1 2.0|
Centrilobular, Fibrosis | 2 | 1 2.0|
Centrilobular, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 17 |
Cyst | | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Fat, Necrosis | 2 3 | 12 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy, Focal | | 1 1.0|
Duct, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Erosion | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 0| 8| 3| 0| 2| 3| 3| 3| | |
| 4| 5| 2| 8| 4| 2| 7| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | | 1 1.0|
Ulcer | 2 | 1 2.0|
Mucosa, Hyperplasia | 2 1 | 5 1.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Erosion | | 1 1.0|
Mineralization | | 1 1.0|
Pigmentation | | 1 2.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Incisor, Dysplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Bacterium | | 1 3.0|
Aorta, Inflammation, Focal, | | |
Suppurative | | 1 3.0|
Aorta, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation, Focal, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Focal Cellular Change | 2 | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Cyst | | 1 1.0|
Pars Distalis, Focal Cellular Change | 1 | 6 1.7|
Pars Distalis, Hyperplasia, Focal | 2 | 5 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 1 1 | 9 1.6|
Follicle, Cyst | | 1 2.0|
Follicular Cell, Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | 1 1 3 2 3 | 33 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 0| 8| 3| 0| 2| 3| 3| 3| | |
| 4| 5| 2| 8| 4| 2| 7| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 2 |
Degeneration, Cystic | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hemorrhage | | 2 4.0|
Follicle, Cyst | 2 2 3 3 | 17 2.9|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Angiectasis | | 1 1.0|
Hydrometra | 2 3 3 | 19 2.9|
Inflammation, Suppurative | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 3 2 4 4 3 3 3 4 3 | 58 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Angiectasis | 4 | 2 4.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 4 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | 1 3 3 2 2 3 | 28 2.5|
Hyperplasia, Lymphoid | 2 3 | 13 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 53 |
Hyperplasia, Lymphoid | 3 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | | 4 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 1.0|
Ulcer | | 1 1.0|
Subcutaneous Tissue, Hyperplasia, | | |
Mast Cell | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 0| 8| 3| 0| 2| 3| 3| 3| | |
| 4| 5| 2| 8| 4| 2| 7| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | 1 1 1 2 | 34 1.6|
Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 1 | 6 2.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hyperplasia, Macrophage | | 2 2.5|
Inflammation, Chronic, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Metaplasia, Osseous | 2 | 2 1.5|
Nephropathy | 1 2 3 1 1 2 | 36 1.5|
Pelvis, Dilatation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 0| 4| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 4| 7| 9| 3| 3| 3| 3| 3| 6| 7| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3|
| 0| 0| 6| 6| 5| 5| 0| 0| 0| 0| 0| 4| 2| 0| 0| 4| 0| 0| 0| 0| 0| 0| 7| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Eosinophilic Focus | X X X X X X X|
Fatty Change | 1 1 1 1 |
Focal Cellular Change | 2 |
Hematopoietic Cell Proliferation | 1 2 2 |
Inflammation, Focal | 1 |
Mixed Cell Focus | X |
Necrosis, Focal | 2 |
Centrilobular, Fibrosis | |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Tooth | + + |
Incisor, Dysplasia | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + + + + + M + + + M + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 0| 4| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 4| 7| 9| 3| 3| 3| 3| 3| 6| 7| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3|
| 0| 0| 6| 6| 5| 5| 0| 0| 0| 0| 0| 4| 2| 0| 0| 4| 0| 0| 0| 0| 0| 0| 7| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | |
Cyst | |
Hemorrhage | 4 4 |
Pars Distalis, Focal Cellular Change | 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 |
Inflammation, Focal | 1 |
Follicular Cell, Hyperplasia | 2 4 2 1 2 2 3 2 4 3 3 3 3 3 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Degeneration, Cystic | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Angiectasis | |
Thrombosis | 4 |
Follicle, Cyst | 3 4 2 3 |
Periovarian Tissue, Hemorrhage | |
__________________________________________________________________________|
Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hydrometra | 3 3 3 2 3 3 3 3 3 2 3 |
Inflammation, Suppurative | 4 2 1 |
Endometrium, Hyperplasia, Cystic | 4 4 3 3 2 3 3 4 3 3 3 3 2 4 4 4 3 3 2 3 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Angiectasis | |
Iliac, Hyperplasia | 3 |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Mast Cell | |
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + M + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Hematopoietic Cell Proliferation | 4 3 3 2 3 2 4 |
Hyperplasia, Lymphoid | 2 2 3 2 3 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 0| 4| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 4| 7| 9| 3| 3| 3| 3| 3| 6| 7| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3|
| 0| 0| 6| 6| 5| 5| 0| 0| 0| 0| 0| 4| 2| 0| 0| 4| 0| 0| 0| 0| 0| 0| 7| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Cyst Epithelial Inclusion | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Foreign Body | 1 1 |
Hemorrhage | 2 1 |
Hyperplasia, Macrophage | 3 3 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Harderian Gland | + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Metaplasia, Osseous | 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 0| 4| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 4| 7| 9| 3| 3| 3| 3| 3| 6| 7| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3|
| 0| 0| 6| 6| 5| 5| 0| 0| 0| 0| 0| 4| 2| 0| 0| 4| 0| 0| 0| 0| 0| 0| 7| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 1 1 2 1 1 1 1 1 2 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 2 2 |
Transitional Epithelium, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 2| 2| 0| 2| 7| 3| 3| 5| 3| 3| 2| 0|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 7| 9| 9| 7| 9| 4| 0| 0| 1| 0| 0| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Eosinophilic Focus | X X X X X X X X X X |
Fatty Change | 1 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | |
Inflammation, Focal | 1 1 |
Mixed Cell Focus | X |
Necrosis, Focal | |
Centrilobular, Fibrosis | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 2| 2| 0| 2| 7| 3| 3| 5| 3| 3| 2| 0|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 7| 9| 9| 7| 9| 4| 0| 0| 1| 0| 0| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | 2 |
Cyst | 2 |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | 1 |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Degeneration, Cystic | 1 |
Inflammation, Focal | |
Follicular Cell, Hyperplasia | 2 3 1 2 2 2 1 2 2 1 2 2 3 2 3 2 2 2 1 3 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Degeneration, Cystic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Thrombosis | |
Follicle, Cyst | 4 4 2 3 3 4 4 |
Periovarian Tissue, Hemorrhage | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 3 3 3 3 3 3 3 3 3 4 3|
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 4 4 3 3 4 3 3 3 3 3 4 2 3 4 4 3 4 3 4 3 4 3 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Angiectasis | 3 |
Iliac, Hyperplasia | |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Mast Cell | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A|
Depletion Cellular | |
Hematopoietic Cell Proliferation | 2 3 2 3 3 2 2 3 |
Hyperplasia, Lymphoid | 2 2 2 3 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 2| 2| 0| 2| 7| 3| 3| 5| 3| 3| 2| 0|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 7| 9| 9| 7| 9| 4| 0| 0| 1| 0| 0| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + I + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 1 2 2 2 2 1 2 1|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Foreign Body | 1 |
Hemorrhage | 1 |
Hyperplasia, Macrophage | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Atrophy | |
Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 2| 2| 0| 2| 7| 3| 3| 5| 3| 3| 2| 0|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 7| 9| 9| 7| 9| 4| 0| 0| 1| 0| 0| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 1 2 2 1 2 1 2 2 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 6| 8| 2| 3| 3| 3| 9| 3| 3| | |
| 0| 8| 7| 9| 0| 0| 0| 5| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.0% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 |
Eosinophilic Focus | X X X | 20 |
Fatty Change | 2 | 6 1.2|
Focal Cellular Change | | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 | 5 1.4|
Inflammation, Focal | | 3 1.0|
Mixed Cell Focus | X X | 4 |
Necrosis, Focal | | 1 2.0|
Centrilobular, Fibrosis | 2 | 1 2.0|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 12 |
Fat, Necrosis | 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Cyst | | 1 1.0|
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
Mucosa, Hyperplasia | 2 1 | 4 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 3 |
Incisor, Dysplasia | | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 6| 8| 2| 3| 3| 3| 9| 3| 3| | |
| 0| 8| 7| 9| 0| 0| 0| 5| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.0% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | I + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Cyst | | 1 2.0|
Hemorrhage | | 2 4.0|
Pars Distalis, Focal Cellular Change | | 2 1.5|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 2 | 4 2.0|
Inflammation, Focal | | 1 1.0|
Follicular Cell, Hyperplasia | 1 3 3 1 2 3 1 1 | 47 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Degeneration, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Angiectasis | | 1 3.0|
Thrombosis | | 1 4.0|
Follicle, Cyst | 2 | 12 3.2|
Periovarian Tissue, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Angiectasis | | 1 2.0|
Hydrometra | 2 3 3 4 4 | 27 3.0|
Inflammation, Suppurative | | 3 2.3|
Endometrium, Hyperplasia, Cystic | 4 3 3 3 3 4 4 4 3 3 | 56 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 13 |
Iliac, Angiectasis | | 1 3.0|
Iliac, Hyperplasia | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Inguinal, Hyperplasia, Mast Cell | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 6| 8| 2| 3| 3| 3| 9| 3| 3| | |
| 0| 8| 7| 9| 0| 0| 0| 5| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.0% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + M + + + + | 57 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Angiectasis | | 2 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 4 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Depletion Cellular | | 1 2.0|
Hematopoietic Cell Proliferation | 1 4 2 2 2 | 20 2.6|
Hyperplasia, Lymphoid | 2 2 2 | 18 2.2|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | | 3 1.7|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | 2 1 | 3 1.7|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | 1 2 1 2 2 | 23 1.7|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 2 3.5|
Cyst Epithelial Inclusion | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 3 2.7|
Foreign Body | | 3 1.0|
Hemorrhage | 1 | 4 1.3|
Hyperplasia, Macrophage | | 2 3.0|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 6| 8| 2| 3| 3| 3| 9| 3| 3| | |
| 0| 8| 7| 9| 0| 0| 0| 5| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.0% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 3.0|
Metaplasia, Osseous | 1 | 2 1.5|
Nephropathy | 1 2 1 | 31 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + | 57 |
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | 2 | 4 2.0|
Transitional Epithelium, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6| 4| 5| 7| 7| 6| 3| 6| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 8| 6| 3| 6| 2| 2| 7| 3| 2| 0| 2| 5| 9| 8| 2| 0| 9| 6| 3| 3| 3| 7| 3|
| 9| 0| 6| 1| 0| 0| 9| 9| 3| 3| 9| 7| 9| 2| 6| 9| 9| 7| 2| 2| 1| 0| 0| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + A + + + + + + + + + A A M + + + +|
Cyst | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + A A + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + A A + + + + A|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + A A + + + + A|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X X |
Eosinophilic Focus | X X X X X X X |
Fatty Change | 1 1 2 2 2 2 2 1|
Hematopoietic Cell Proliferation | 3 |
Infarct | 4 |
Inflammation, Focal | |
Mixed Cell Focus | X X X |
Necrosis, Focal | 2 3 |
__________________________________________________________________________|
Mesentery | |
Hemorrhage | |
Inflammation, Chronic | |
Mineralization | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A A + + + + +|
Atrophy, Focal | |
Edema | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +|
Inflammation, Chronic | 2 2 |
Ulcer | 2 |
Mucosa, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
Inflammation, Chronic | 2 |
Mineralization | 1 |
Pigmentation | |
Mucosa, Hyperplasia | 1 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + |
Incisor, Dysplasia | 2 3 3 2 3 3 3 2 4 3 2 3 3 3 3 4 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6| 4| 5| 7| 7| 6| 3| 6| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 8| 6| 3| 6| 2| 2| 7| 3| 2| 0| 2| 5| 9| 8| 2| 0| 9| 6| 3| 3| 3| 7| 3|
| 9| 0| 6| 1| 0| 0| 9| 9| 3| 3| 9| 7| 9| 2| 6| 9| 9| 7| 2| 2| 1| 0| 0| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Focal Cellular Change | |
Subcapsular, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + M + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + I M M + + I + +|
Cyst | 2 |
Pars Distalis, Focal Cellular Change | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration, Cystic | 2 1 2 1 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + +|
Dilatation | 3 3 3 4 3 3 3 3 3|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Degeneration, Cystic | 3 3 4 4 3 3 3 3 3 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 4 2 3 3 4 3 3 2 3 3 3 3 4|
Hemorrhage | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Granuloma Sperm | 2 |
Germinal Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6| 4| 5| 7| 7| 6| 3| 6| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 8| 6| 3| 6| 2| 2| 7| 3| 2| 0| 2| 5| 9| 8| 2| 0| 9| 6| 3| 3| 3| 7| 3|
| 9| 0| 6| 1| 0| 0| 9| 9| 3| 3| 9| 7| 9| 2| 6| 9| 9| 7| 2| 2| 1| 0| 0| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Congestion | 3 |
Hypercellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
Angiectasis | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 3 3 |
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A + + + + +|
Angiectasis | 2 4 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 2 2 2 2 |
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +|
Depletion Cellular | 3 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 4 4 3 3 2 3 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + M + + + + + + + + I + M + + + +|
Cyst | 2 2 2 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Subcutaneous Tissue, Abscess | 3 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6| 4| 5| 7| 7| 6| 3| 6| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 8| 6| 3| 6| 2| 2| 7| 3| 2| 0| 2| 5| 9| 8| 2| 0| 9| 6| 3| 3| 3| 7| 3|
| 9| 0| 6| 1| 0| 0| 9| 9| 3| 3| 9| 7| 9| 2| 6| 9| 9| 7| 2| 2| 1| 0| 0| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia, Macrophage | 2 2 3 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic, Focal | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Thrombosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + + + + + + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 2 |
Nephropathy | 1 2 2 2 2 2 2 2 4 2 1 2 2 3 2 2 2 2 2|
Pelvis, Dilatation | 2 |
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Dilatation | 3 |
__________________________________________________________________________|
Urethra | +|
Inflammation, Chronic | 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +|
Dilatation | 4 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 3| 2| 2| 2| 2| 0| 2| 2| 4| 2| 4| 3| 8| 3| 3| 3| 5| 0| 5|
| 9| 9| 6| 9| 9| 9| 6| 9| 9| 9| 9| 7| 9| 9| 7| 7| 3| 0| 9| 0| 0| 0| 2| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X X X X|
Fatty Change | 2 1 2 1 |
Hematopoietic Cell Proliferation | |
Infarct | 4 |
Inflammation, Focal | 1 1 |
Mixed Cell Focus | X |
Necrosis, Focal | 3 2 |
__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | |
Inflammation, Chronic | 1 |
Mineralization | 1 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 3 |
Edema | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 |
Ulcer | |
Mucosa, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | |
Pigmentation | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + |
Incisor, Dysplasia | 3 3 2 4 2 2 2 1 1 3 4 3 4 2 3 2 3 4 3 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 3| 2| 2| 2| 2| 0| 2| 2| 4| 2| 4| 3| 8| 3| 3| 3| 5| 0| 5|
| 9| 9| 6| 9| 9| 9| 6| 9| 9| 9| 9| 7| 9| 9| 7| 7| 3| 0| 9| 0| 0| 0| 2| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Focal Cellular Change | 2 |
Subcapsular, Hyperplasia, Focal | 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + M + + + + + + + +|
Cyst | 1 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | 2 |
Pars Distalis, Focal Cellular Change | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Degeneration, Cystic | 1 2 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + |
Dilatation | 2 3 2 3 3 4 4 4 3 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Degeneration, Cystic | 3 3 3 1 3 3 3 3 3 3 2 |
Inflammation, Chronic | 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 1 3 4 3 3 4 2 3 4 4 3 4 2|
Hemorrhage | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Granuloma Sperm | |
Germinal Epithelium, Degeneration | 2 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 3| 2| 2| 2| 2| 0| 2| 2| 4| 2| 4| 3| 8| 3| 3| 3| 5| 0| 5|
| 9| 9| 6| 9| 9| 9| 6| 9| 9| 9| 9| 7| 9| 9| 7| 7| 3| 0| 9| 0| 0| 0| 2| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + |
Angiectasis | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 2 3 2|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 3 3 4 2 3|
Hyperplasia, Lymphoid | 2 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + M + I|
Cyst | 2 2 1 2 |
Epithelial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Edema | 2 |
Subcutaneous Tissue, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 3| 2| 2| 2| 2| 0| 2| 2| 4| 2| 4| 3| 8| 3| 3| 3| 5| 0| 5|
| 9| 9| 6| 9| 9| 9| 6| 9| 9| 9| 9| 7| 9| 9| 7| 7| 3| 0| 9| 0| 0| 0| 2| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia, Macrophage | 1 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic, Focal | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 1 |
Artery, Thrombosis | 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
Nephropathy | 1 2 2 2 3 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
Pelvis, Dilatation | 3 3 |
Renal Tubule, Degeneration, Hyaline | 4 |
Renal Tubule, Dilatation | 2 |
__________________________________________________________________________|
Urethra | |
Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| | |
DAY ON TEST | 5| 7| 0| 0| 2| 9| 7| 2| 4| 0| | |
| 3| 5| 8| 2| 9| 8| 3| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + + | 55 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Basophilic Focus | | 2 |
Clear Cell Focus | X X | 10 |
Eosinophilic Focus | X X X X X | 20 |
Fatty Change | | 12 1.6|
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Infarct | | 2 4.0|
Inflammation, Focal | | 2 1.0|
Mixed Cell Focus | | 4 |
Necrosis, Focal | 1 | 5 2.2|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Mineralization | | 1 1.0|
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy, Focal | 1 | 3 2.0|
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Inflammation, Chronic | 1 1 | 6 1.5|
Ulcer | | 1 2.0|
Mucosa, Hyperplasia | 1 1 1 | 7 1.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 2.0|
Mineralization | | 1 1.0|
Pigmentation | 1 | 1 1.0|
Mucosa, Hyperplasia | 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| | |
DAY ON TEST | 5| 7| 0| 0| 2| 9| 7| 2| 4| 0| | |
| 3| 5| 8| 2| 9| 8| 3| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + + + + | 44 |
Incisor, Dysplasia | 3 4 3 2 3 | 44 2.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
Focal Cellular Change | 2 | 2 2.0|
Subcapsular, Hyperplasia, Focal | | 5 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + | 55 |
Cyst | | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + M + | 52 |
Cyst | | 2 2.0|
Pars Distalis, Focal Cellular Change | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
Degeneration, Cystic | | 7 1.4|
Follicle, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | 2 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + | 23 |
Dilatation | 3 2 3 3 | 23 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Granuloma Sperm | | 4 2.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 27 |
Degeneration, Cystic | 2 3 3 3 2 | 26 2.9|
Inflammation, Chronic | | 2 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| | |
DAY ON TEST | 5| 7| 0| 0| 2| 9| 7| 2| 4| 0| | |
| 3| 5| 8| 2| 9| 8| 3| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | 4 2 3 4 3 3 | 35 3.0|
Hemorrhage | | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Granuloma Sperm | | 1 2.0|
Germinal Epithelium, Degeneration | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Congestion | | 1 3.0|
Hypercellularity | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 9 |
Angiectasis | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia | 2 | 3 2.7|
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 57 |
Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Angiectasis | 2 2 3 2 | 13 2.3|
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 10 2.1|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Depletion Cellular | | 2 3.0|
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 4 3 2 3 2 4 | 21 2.9|
Hyperplasia, Lymphoid | 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 53 |
Cyst | 2 2 | 9 1.9|
Epithelial Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| | |
DAY ON TEST | 5| 7| 0| 0| 2| 9| 7| 2| 4| 0| | |
| 3| 5| 8| 2| 9| 8| 3| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Abscess | | 1 3.0|
Subcutaneous Tissue, Edema | | 1 2.0|
Subcutaneous Tissue, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 1 1.0|
Hyperplasia, Macrophage | | 4 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Chronic, Focal | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 4 1.5|
Artery, Thrombosis | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 10 |
Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | 2 | 7 1.9|
Nephropathy | 1 1 2 2 2 2 2 2 | 51 2.0|
Pelvis, Dilatation | | 3 2.7|
Renal Tubule, Degeneration, Hyaline | | 1 4.0|
Renal Tubule, Dilatation | | 2 2.5|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| | |
DAY ON TEST | 5| 7| 0| 0| 2| 9| 7| 2| 4| 0| | |
| 3| 5| 8| 2| 9| 8| 3| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Dilatation | | 3 3.3|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 0| 2| 2| 2| 6| 2| 1| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2|
| 9| 6| 9| 9| 7| 9| 9| 5| 1| 9| 9| 9| 7| 9| 9| 9| 4| 9| 9| 9| 1| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + A + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X |
Clear Cell Focus | X X X X X X X X X X X X X |
Eosinophilic Focus | X X X X X X X X X|
Fatty Change | 2 2 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Infarct | |
Mixed Cell Focus | X |
Necrosis, Focal | 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Hyperplasia, Mast Cell | 2 |
Fat, Necrosis | 2 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +|
Atrophy, Focal | |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | 2 1 |
Ulcer | 1 |
Mucosa, Hyperplasia | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Erosion | |
Pigmentation | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + +|
Incisor, Dysplasia | 3 1 2 3 1 1 2 3 3 3 3 3 1 3 2 3 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 0| 2| 2| 2| 6| 2| 1| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2|
| 9| 6| 9| 9| 7| 9| 9| 5| 1| 9| 9| 9| 7| 9| 9| 9| 4| 9| 9| 9| 1| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Cyst | |
Focal Cellular Change | 2 1 2 1 |
Subcapsular, Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Degeneration, Cystic | 1 1 |
Follicular Cell, Hyperplasia | 3 1 1 2 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + +|
Dilatation | 3 4 3 4 3 3|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic | 4 |
Necrosis | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 3 3 3 4 3 3 3 3 3 2 3|
Inflammation, Chronic | 3 4 4|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 2 3 3 3 3 4 4 3 2 2 1 3 3|
Hemorrhage | 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis, Focal | |
__________________________________________________________________________|
Lymph Node | + + +|
Inguinal, Hyperplasia, Lymphoid | 2|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 0| 2| 2| 2| 6| 2| 1| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2|
| 9| 6| 9| 9| 7| 9| 9| 5| 1| 9| 9| 9| 7| 9| 9| 9| 4| 9| 9| 9| 1| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Hyperplasia | 3 |
Pancreatic, Hyperplasia | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + A + + + + + + + +|
Angiectasis | 2 2 2 2 2 2 1 2 2 2 2|
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Lymphoid | 2 2 2|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +|
Depletion Cellular | 3 2 |
Hematopoietic Cell Proliferation | 4 3 2 3 2 3 2 3 |
Hyperplasia, Lymphoid | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + M + + + M + + + + + + I + + + M + + M + + + + +|
Cyst | |
Hyperplasia, Lymphoid | |
Mineralization | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Ulcer | 2 |
Epidermis, Hyperplasia, Focal | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | |
Hemorrhage | 1 |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 1 |
Bronchus, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 0| 2| 2| 2| 6| 2| 1| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2|
| 9| 6| 9| 9| 7| 9| 9| 5| 1| 9| 9| 9| 7| 9| 9| 9| 4| 9| 9| 9| 1| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +|
Congestion | |
Cyst | 2 |
Hydronephrosis | |
Nephropathy | 2 2 2 1 2 1 2 1 2 2 1 1 1 2 2 2 2 2 2 2 1 2 1 2|
Pelvis, Dilatation | 2 |
__________________________________________________________________________|
Urethra | |
Angiectasis | |
Dilatation | |
Inflammation, Acute | |
Bulbourethral Gland, Angiectasis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
Dilatation | |
Inflammation, Chronic | 1 2 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 0| 7| 7| 0| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 0| 4| 2| 2| 7| 2| 2| 1| 2| 0| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 9| 0| 2| 2|
| 9| 5| 9| 9| 9| 3| 9| 9| 0| 9| 9| 9| 2| 9| 0| 9| 9| 7| 9| 1| 9| 7| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + M + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + A + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | X X X |
Clear Cell Focus | X X X X X X X X X X |
Eosinophilic Focus | X X X X X X X X X X X X|
Fatty Change | 2 1 1 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Infarct | |
Mixed Cell Focus | X X |
Necrosis, Focal | 2 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + |
Hyperplasia, Mast Cell | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Pigmentation | 1 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + |
Incisor, Dysplasia | 3 3 2 3 1 3 2 3 2 3 3 3 1 3 3 3 4 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 0| 7| 7| 0| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 0| 4| 2| 2| 7| 2| 2| 1| 2| 0| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 9| 0| 2| 2|
| 9| 5| 9| 9| 9| 3| 9| 9| 0| 9| 9| 9| 2| 9| 0| 9| 9| 7| 9| 1| 9| 7| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | 2 |
Focal Cellular Change | 1 1 |
Subcapsular, Hyperplasia, Focal | 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Degeneration, Cystic | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + M + + + + +|
Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 |
Follicular Cell, Hyperplasia | 1 2 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + |
Dilatation | 3 3 4 3 3 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Penis | |
Inflammation, Chronic | |
Necrosis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 3 4 3 3 3 4 3 4 4 4 3|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 3 2 2 2 3 4 3 3 4 4 3|
Hemorrhage | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis, Focal | 1 |
__________________________________________________________________________|
Lymph Node | + |
Inguinal, Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 0| 7| 7| 0| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 0| 4| 2| 2| 7| 2| 2| 1| 2| 0| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 9| 0| 2| 2|
| 9| 5| 9| 9| 9| 3| 9| 9| 0| 9| 9| 9| 2| 9| 0| 9| 9| 7| 9| 1| 9| 7| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Hyperplasia | |
Pancreatic, Hyperplasia | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 2 1 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 1 3 2 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 4 2 |
Hematopoietic Cell Proliferation | 2 3 3 3|
Hyperplasia, Lymphoid | 2 3 2 2 1 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | 1 2 2 |
Hyperplasia, Lymphoid | 3 |
Mineralization | 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M + M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
Ulcer | |
Epidermis, Hyperplasia, Focal | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Foreign Body | 1 |
Hemorrhage | |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Bronchus, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 0| 7| 7| 0| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 0| 4| 2| 2| 7| 2| 2| 1| 2| 0| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 9| 0| 2| 2|
| 9| 5| 9| 9| 9| 3| 9| 9| 0| 9| 9| 9| 2| 9| 0| 9| 9| 7| 9| 1| 9| 7| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +|
Congestion | 1 |
Cyst | 2 2 |
Hydronephrosis | 1 |
Nephropathy | 1 2 2 2 1 2 2 3 2 2 2 2 1 2 2 2 2 4 2 1 3|
Pelvis, Dilatation | |
__________________________________________________________________________|
Urethra | + |
Angiectasis | |
Dilatation | |
Inflammation, Acute | |
Bulbourethral Gland, Angiectasis | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 6| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 2| 1| 4| 3| 0| 2| 2| 2| 2| | |
| 7| 9| 0| 5| 0| 7| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + M + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 3 2.0|
Basophilic Focus | X X | 8 |
Clear Cell Focus | X X | 25 |
Eosinophilic Focus | X X X | 24 |
Fatty Change | | 5 1.6|
Fibrosis, Focal | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 3 | 1 3.0|
Infarct | 3 | 1 3.0|
Mixed Cell Focus | X | 4 |
Necrosis, Focal | 3 | 3 2.3|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Hyperplasia, Mast Cell | | 1 2.0|
Fat, Necrosis | 3 | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy, Focal | 2 | 2 1.5|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Erosion | 2 | 2 2.0|
Inflammation, Chronic | 2 2 | 4 1.8|
Ulcer | | 1 1.0|
Mucosa, Hyperplasia | 2 1 2 1 | 7 1.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Erosion | | 1 2.0|
Pigmentation | | 3 1.3|
__________________________________________________________________________|____________|
Tooth | + + + + + + | 41 |
Incisor, Dysplasia | 3 3 3 3 2 1 | 41 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 6| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 2| 1| 4| 3| 0| 2| 2| 2| 2| | |
| 7| 9| 0| 5| 0| 7| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Cyst | | 1 2.0|
Focal Cellular Change | | 6 1.3|
Subcapsular, Hyperplasia, Focal | 1 | 7 1.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 1 | 5 1.0|
Follicular Cell, Hyperplasia | 3 3 | 18 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 13 |
Dilatation | 3 | 13 3.2|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Granuloma Sperm | 3 | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Chronic | | 1 4.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 36 |
Degeneration, Cystic | 3 4 3 4 3 | 33 3.2|
Inflammation, Chronic | 2 | 5 3.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Dilatation | | 1 2.0|
Inflammation, Chronic | | 2 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 6| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 2| 1| 4| 3| 0| 2| 2| 2| 2| | |
| 7| 9| 0| 5| 0| 7| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | 4 3 | 31 3.0|
Hemorrhage | | 3 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
Inguinal, Hyperplasia, Lymphoid | | 2 2.0|
Inguinal, Hyperplasia | | 1 3.0|
Pancreatic, Hyperplasia | 3 | 1 3.0|
Renal, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Angiectasis | 2 2 2 2 | 23 1.9|
Hematopoietic Cell Proliferation | 2 | 4 2.3|
Hyperplasia, Lymphoid | | 6 2.0|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Depletion Cellular | 2 | 6 2.7|
Hematopoietic Cell Proliferation | 2 2 | 14 2.6|
Hyperplasia, Lymphoid | 3 | 12 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 54 |
Cyst | | 3 1.7|
Hyperplasia, Lymphoid | | 1 3.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 2 1.5|
Ulcer | | 1 2.0|
Epidermis, Hyperplasia, Focal | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 6| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 2| 1| 4| 3| 0| 2| 2| 2| 2| | |
| 7| 9| 0| 5| 0| 7| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Foreign Body | | 1 1.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Macrophage | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 4 1.5|
Bronchus, Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Congestion | | 1 1.0|
Cyst | 1 | 4 1.8|
Hydronephrosis | | 1 1.0|
Nephropathy | 2 2 3 2 2 1 1 2 2 | 54 1.8|
Pelvis, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + | 2 |
Angiectasis | 3 | 1 3.0|
Dilatation | 3 | 1 3.0|
Inflammation, Acute | 2 | 1 2.0|
Bulbourethral Gland, Angiectasis | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Dilatation | 3 4 | 2 3.5|
Inflammation, Chronic | 2 | 3 1.7|
Transitional Epithelium, Hyperplasia | 2 1 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 8| 2| 2| 2| 7| 7| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2|
| 8| 8| 8| 7| 0| 8| 8| 8| 4| 6| 7| 7| 8| 8| 8| 8| 8| 8| 7| 8| 8| 7| 6| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Clear Cell Focus | X X X X X X X X |
Congestion | 4 |
Eosinophilic Focus | X X X X X X X X X X X X|
Fatty Change | 1 2 |
Hemorrhage | |
Infarct | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | |
Mixed Cell Focus | |
Necrosis, Focal | 2 2 |
Thrombosis | 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Cyst | 3 |
Inflammation, Chronic | 2 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Edema | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + +|
Incisor, Dysplasia | 3 1 2 3 3 3 3 1 2 3 2 3 2 3|
Incisor, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 8| 2| 2| 2| 7| 7| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2|
| 8| 8| 8| 7| 0| 8| 8| 8| 4| 6| 7| 7| 8| 8| 8| 8| 8| 8| 7| 8| 8| 7| 6| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Focal Cellular Change | |
Subcapsular, Hyperplasia, Focal | 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 2 1 1 1|
Inflammation, Focal | 1 |
Follicular Cell, Hyperplasia | 1 1 1 3 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + +|
Dilatation | 2 2 3 2 3 3 3 4|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
Inflammation, Chronic | 3 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Degeneration, Cystic | 4 4 4 2 3 1 1 3 4 4 3 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 1 1 3 3 3 2 3 2 2 1 4 4 4 2 4|
Hemorrhage | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node | |
Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 8| 2| 2| 2| 7| 7| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2|
| 8| 8| 8| 7| 0| 8| 8| 8| 4| 6| 7| 7| 8| 8| 8| 8| 8| 8| 7| 8| 8| 7| 6| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + M|
Angiectasis | 2 2 3 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
Hematopoietic Cell Proliferation | 3 4 3 3 2 2 |
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + I + + M + + + + + + + + +|
Cyst | 2 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M M M + M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Epidermis, Hyperplasia, Focal | 2 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Macrophage | |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 8| 2| 2| 2| 7| 7| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2|
| 8| 8| 8| 7| 0| 8| 8| 8| 4| 6| 7| 7| 8| 8| 8| 8| 8| 8| 7| 8| 8| 7| 6| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | 4 |
Nephropathy | 2 2 2 2 1 2 2 2 2 3 2 1 2 1 2 2 2 1 2 2 2 1 2|
Artery, Inflammation, Chronic | 2 |
Pelvis, Dilatation | |
Renal Tubule, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +|
Dilatation | |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 4| 6| 7| 5| 7| 7|
DAY ON TEST | 8| 0| 2| 2| 2| 2| 2| 1| 7| 2| 4| 1| 2| 2| 2| 2| 2| 8| 6| 3| 9| 2| 8| 2| 2|
| 6| 9| 8| 8| 8| 8| 8| 1| 5| 2| 7| 6| 8| 8| 8| 8| 8| 9| 2| 4| 5| 8| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + A + +|
Angiectasis | |
Basophilic Focus | X X X X X X X |
Clear Cell Focus | X X X X X X X X|
Congestion | |
Eosinophilic Focus | X X X X X X X X X X X X X X X X X|
Fatty Change | 2 1 2 |
Hemorrhage | |
Infarct | 3 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 2 2 |
Mixed Cell Focus | X |
Necrosis, Focal | 3 2 |
Thrombosis | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Cyst | |
Inflammation, Chronic | 2 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +|
Atrophy, Focal | |
Edema | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + +|
Incisor, Dysplasia | 3 2 3 1 2 4 3 3 3 3 3 3 2 1|
Incisor, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 4| 6| 7| 5| 7| 7|
DAY ON TEST | 8| 0| 2| 2| 2| 2| 2| 1| 7| 2| 4| 1| 2| 2| 2| 2| 2| 8| 6| 3| 9| 2| 8| 2| 2|
| 6| 9| 8| 8| 8| 8| 8| 1| 5| 2| 7| 6| 8| 8| 8| 8| 8| 9| 2| 4| 5| 8| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Focal Cellular Change | 2 |
Subcapsular, Hyperplasia, Focal | 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A + +|
Degeneration, Cystic | 2 1 |
Inflammation, Focal | |
Follicular Cell, Hyperplasia | 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + |
Dilatation | 4 3 4 4 3 4 3 4 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + +|
Degeneration, Cystic | 3 2 4 3 4 4 2 3 4 3|
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 3 3 2 2 4 3 4 3 4 3 3 3 2 4|
Hemorrhage | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Lymph Node | + |
Angiectasis | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 4| 6| 7| 5| 7| 7|
DAY ON TEST | 8| 0| 2| 2| 2| 2| 2| 1| 7| 2| 4| 1| 2| 2| 2| 2| 2| 8| 6| 3| 9| 2| 8| 2| 2|
| 6| 9| 8| 8| 8| 8| 8| 1| 5| 2| 7| 6| 8| 8| 8| 8| 8| 9| 2| 4| 5| 8| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Angiectasis | 1 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Lymphoid | 2 2 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + M + +|
Depletion Cellular | 2 3 1 |
Hematopoietic Cell Proliferation | 3 4 3 4 2 3 3 |
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + M + + A + +|
Cyst | 2 1 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
Epidermis, Hyperplasia, Focal | |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Macrophage | |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +|
Cyst | 1 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 5| 4| 6| 7| 5| 7| 7|
DAY ON TEST | 8| 0| 2| 2| 2| 2| 2| 1| 7| 2| 4| 1| 2| 2| 2| 2| 2| 8| 6| 3| 9| 2| 8| 2| 2|
| 6| 9| 8| 8| 8| 8| 8| 1| 5| 2| 7| 6| 8| 8| 8| 8| 8| 9| 2| 4| 5| 8| 0| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | |
Nephropathy | 2 2 2 2 1 2 2 3 1 2 2 1 2 1 2 2 2 2 3 2 2 2 1|
Artery, Inflammation, Chronic | |
Pelvis, Dilatation | 2 |
Renal Tubule, Dilatation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +|
Dilatation | 3 |
Inflammation, Chronic | 1 |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 4| 4| 2| 2| 1| 2| 2| 2| | |
| 1| 8| 6| 6| 8| 8| 2| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X | 10 |
Clear Cell Focus | X X X X X | 21 |
Congestion | | 1 4.0|
Eosinophilic Focus | X X | 31 |
Fatty Change | 2 2 1 | 8 1.6|
Hemorrhage | 4 | 1 4.0|
Infarct | 4 | 2 3.5|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Focal | 2 | 3 2.0|
Mixed Cell Focus | X X | 3 |
Necrosis, Focal | 2 | 5 2.2|
Thrombosis | | 1 1.0|
Centrilobular, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 7 |
Cyst | | 1 3.0|
Inflammation, Chronic | | 2 2.0|
Fat, Necrosis | 2 | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy, Focal | 4 | 1 4.0|
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Inflammation, Chronic | 1 | 1 1.0|
Ulcer | 1 | 1 1.0|
Mucosa, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Tooth | + + + + + | 33 |
Incisor, Dysplasia | 3 2 3 3 3 | 33 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 4| 4| 2| 2| 1| 2| 2| 2| | |
| 1| 8| 6| 6| 8| 8| 2| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Incisor, Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
Focal Cellular Change | | 1 2.0|
Subcapsular, Hyperplasia, Focal | 1 2 3 | 7 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M M + + + + + | 56 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 1 2 | 10 1.4|
Inflammation, Focal | | 1 1.0|
Follicular Cell, Hyperplasia | 3 1 2 | 15 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + | 21 |
Dilatation | 4 3 3 3 | 21 3.2|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Granuloma Sperm | 3 | 2 2.5|
Inflammation, Chronic | | 3 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 24 |
Degeneration, Cystic | 3 3 | 23 3.1|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Dilatation | | 2 2.0|
Inflammation, Chronic | | 2 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | 4 3 3 3 3 | 36 2.9|
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 4| 4| 2| 2| 1| 2| 2| 2| | |
| 1| 8| 6| 6| 8| 8| 2| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Angiectasis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Angiectasis | 2 2 2 | 17 2.0|
Hematopoietic Cell Proliferation | 2 | 4 2.3|
Hyperplasia, Lymphoid | 2 | 9 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Depletion Cellular | 2 | 5 2.2|
Hematopoietic Cell Proliferation | 4 | 14 3.1|
Hyperplasia, Lymphoid | 1 2 | 8 1.9|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 55 |
Cyst | 2 | 7 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 2 1.5|
Epidermis, Hyperplasia, Focal | | 1 2.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 4| 4| 2| 2| 1| 2| 2| 2| | |
| 1| 8| 6| 6| 8| 8| 2| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Congestion | 3 | 1 3.0|
Hyperplasia, Macrophage | 3 | 1 3.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Cyst | | 3 1.0|
Hydronephrosis | | 1 4.0|
Nephropathy | 2 2 3 2 2 1 2 2 1 | 55 1.9|
Artery, Inflammation, Chronic | | 1 2.0|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Dilatation | 3 | 2 3.0|
Inflammation, Chronic | | 1 1.0|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 4| 5| 5| 7| 3| 6| 6| 7| 1| 1| 5| 6| 4| 7| 6| 6| 1| 4| 7| 7| 7| 2| 7| 3|
DAY ON TEST | 2| 6| 5| 6| 2| 9| 0| 8| 0| 1| 2| 1| 2| 8| 2| 7| 1| 1| 8| 2| 2| 2| 6| 0| 7|
| 8| 0| 2| 7| 8| 6| 2| 4| 9| 2| 5| 1| 8| 9| 6| 1| 4| 8| 6| 8| 8| 8| 9| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Suppurative | 3 |
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + A + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | 4 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | X |
Fatty Change | 2 3 3 2 2 2 2 1 2 2 2 3 2 3|
Focal Cellular Change | 2 |
Mixed Cell Focus | X |
Necrosis, Focal | 3 |
Tension Lipidosis | X X X |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Angiectasis | 2 |
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 |
Ulcer | 1 2 |
Mucosa, Hyperplasia | 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | 1 |
Pigmentation | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + |
Incisor, Dysplasia | 1 2 1 1 2 2 3 3 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 4| 5| 5| 7| 3| 6| 6| 7| 1| 1| 5| 6| 4| 7| 6| 6| 1| 4| 7| 7| 7| 2| 7| 3|
DAY ON TEST | 2| 6| 5| 6| 2| 9| 0| 8| 0| 1| 2| 1| 2| 8| 2| 7| 1| 1| 8| 2| 2| 2| 6| 0| 7|
| 8| 0| 2| 7| 8| 6| 2| 4| 9| 2| 5| 1| 8| 9| 6| 1| 4| 8| 6| 8| 8| 8| 9| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Focal Cellular Change | 1 |
Subcapsular, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + M + I|
Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + + A|
Degeneration, Cystic | 2 2 2 |
Follicular Cell, Hyperplasia | 2 2 3 3 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Dilatation | 2 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + |
Degeneration, Cystic | 4 4 4 4 3 3 3 4 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Dilatation | 2 4 3 4 |
Hemorrhage | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Mineralization | 2 |
Germinal Epithelium, Degeneration | 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | |
Inguinal, Cyst | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 4| 5| 5| 7| 3| 6| 6| 7| 1| 1| 5| 6| 4| 7| 6| 6| 1| 4| 7| 7| 7| 2| 7| 3|
DAY ON TEST | 2| 6| 5| 6| 2| 9| 0| 8| 0| 1| 2| 1| 2| 8| 2| 7| 1| 1| 8| 2| 2| 2| 6| 0| 7|
| 8| 0| 2| 7| 8| 6| 2| 4| 9| 2| 5| 1| 8| 9| 6| 1| 4| 8| 6| 8| 8| 8| 9| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 1 2 1 2 2 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + M + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 2 3 2 3 2 1 4 3 3 2 4|
Fibrosis | |
Hematopoietic Cell Proliferation | 4 2 3 2 |
Hyperplasia, Lymphoid | 1 1 |
__________________________________________________________________________|
Thymus | + + M + + M + + + + + + + + M + + + + + I + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hair Follicle, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage | |
Inflammation, Acute, Focal | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + A|
Atrophy, Focal | |
Congestion | |
Cyst | |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 7| 4| 5| 5| 7| 3| 6| 6| 7| 1| 1| 5| 6| 4| 7| 6| 6| 1| 4| 7| 7| 7| 2| 7| 3|
DAY ON TEST | 2| 6| 5| 6| 2| 9| 0| 8| 0| 1| 2| 1| 2| 8| 2| 7| 1| 1| 8| 2| 2| 2| 6| 0| 7|
| 8| 0| 2| 7| 8| 6| 2| 4| 9| 2| 5| 1| 8| 9| 6| 1| 4| 8| 6| 8| 8| 8| 9| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 2 1 2 2 2 2 2 2 2 1 1 1 1 1 2 2 2 2 |
Artery, Inflammation, Chronic | |
Pelvis, Dilatation | |
Renal Tubule, Dilatation | |
__________________________________________________________________________|
Ureter | |
Dilatation | |
__________________________________________________________________________|
Urethra | + |
Dilatation | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation, Multiple,| |
Greater Than Five | X |
Dilatation | 3 |
Inflammation, Chronic | 2 3 2 3 2 3 2 3 3 3 1 3 1 3 1 3 4 2|
Artery, Inflammation, Chronic | 2 |
Transitional Epithelium, Hyperplasia | 1 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 6| 7| 1| 7| 5| 1| 7| 7| 7| 7| 4| 7| 0| 1| 7| 6| 1| 1| 5| 7| 3|
DAY ON TEST | 8| 2| 1| 2| 8| 2| 0| 2| 8| 4| 2| 2| 2| 2| 8| 2| 9| 3| 2| 8| 7| 8| 2| 0| 6|
| 6| 5| 1| 8| 7| 8| 6| 8| 0| 6| 7| 8| 8| 8| 6| 8| 3| 9| 8| 4| 4| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Suppurative | |
__________________________________________________________________________|
Gallbladder | M + + + M + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + A + A + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + A + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X 2 X X X X X X |
Eosinophilic Focus | X X X X X X |
Fatty Change | 3 2 2 3 1 2 3 2 2 2 3 3|
Focal Cellular Change | 2 |
Mixed Cell Focus | X X X X |
Necrosis, Focal | |
Tension Lipidosis | X X |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + |
Angiectasis | |
Inflammation, Chronic | |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + A + + +|
Necrosis | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Chronic | 1 1 1 1 |
Ulcer | 2 1 |
Mucosa, Hyperplasia | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + A + + +|
Erosion | 2 1 2|
Mineralization | 1 |
Pigmentation | 2 2|
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + +|
Incisor, Dysplasia | 2 1 2 1 3 2 3 2 2 1 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 6| 7| 1| 7| 5| 1| 7| 7| 7| 7| 4| 7| 0| 1| 7| 6| 1| 1| 5| 7| 3|
DAY ON TEST | 8| 2| 1| 2| 8| 2| 0| 2| 8| 4| 2| 2| 2| 2| 8| 2| 9| 3| 2| 8| 7| 8| 2| 0| 6|
| 6| 5| 1| 8| 7| 8| 6| 8| 0| 6| 7| 8| 8| 8| 6| 8| 3| 9| 8| 4| 4| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Focal Cellular Change | |
Subcapsular, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + M + + +|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + M + + M|
Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Degeneration, Cystic | 1 |
Follicular Cell, Hyperplasia | 3 1 1 3 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + |
Degeneration, Cystic | 3 3 3 4 3 3 2 1 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + M + A + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Dilatation | 3 2 2 2 2 |
Hemorrhage | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + A + + +|
Degeneration | |
Mineralization | |
Germinal Epithelium, Degeneration | 3 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 4 |
__________________________________________________________________________|
Lymph Node | |
Inguinal, Cyst | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 6| 7| 1| 7| 5| 1| 7| 7| 7| 7| 4| 7| 0| 1| 7| 6| 1| 1| 5| 7| 3|
DAY ON TEST | 8| 2| 1| 2| 8| 2| 0| 2| 8| 4| 2| 2| 2| 2| 8| 2| 9| 3| 2| 8| 7| 8| 2| 0| 6|
| 6| 5| 1| 8| 7| 8| 6| 8| 0| 6| 7| 8| 8| 8| 6| 8| 3| 9| 8| 4| 4| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + M + + M|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + M + + |
Angiectasis | 2 2 2 1 2 |
Hyperplasia, Lymphoid | 2 3 3 2 |
__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + + + + M + + +|
Depletion Cellular | 2 2 2 4 2 2 3 2 3 4|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 1 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + M M A + + +|
Cyst | 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hair Follicle, Atrophy | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 4 3|
Hemorrhage | 1 |
Inflammation, Acute, Focal | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +|
Atrophy, Focal | 2 |
Congestion | 3 2 2 2 |
Cyst | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 6| 7| 1| 7| 5| 1| 7| 7| 7| 7| 4| 7| 0| 1| 7| 6| 1| 1| 5| 7| 3|
DAY ON TEST | 8| 2| 1| 2| 8| 2| 0| 2| 8| 4| 2| 2| 2| 2| 8| 2| 9| 3| 2| 8| 7| 8| 2| 0| 6|
| 6| 5| 1| 8| 7| 8| 6| 8| 0| 6| 7| 8| 8| 8| 6| 8| 3| 9| 8| 4| 4| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 1 1 2 2 2 1 2 1 2 2 2 2 1 2 1 2 |
Artery, Inflammation, Chronic | 2 |
Pelvis, Dilatation | |
Renal Tubule, Dilatation | 1 |
__________________________________________________________________________|
Ureter | |
Dilatation | |
__________________________________________________________________________|
Urethra | + |
Dilatation | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +|
Calculus Gross Observation, Multiple,| |
Greater Than Five | |
Dilatation | |
Inflammation, Chronic | 4 3 3 2 3 3 2 1 3 1 2 1 2 1|
Artery, Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | 2 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 0| 3| 6| 7| 7| | |
DAY ON TEST | 0| 7| 2| 3| 2| 9| 1| 3| 2| 2| | |
| 7| 7| 8| 1| 8| 4| 8| 0| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Inflammation, Focal, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 55 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Basophilic Focus | X X X X | 6 |
Clear Cell Focus | X X X | 20 2.0|
Eosinophilic Focus | X X X | 10 |
Fatty Change | 2 2 2 | 29 2.2|
Focal Cellular Change | | 2 2.0|
Mixed Cell Focus | | 5 |
Necrosis, Focal | | 1 3.0|
Tension Lipidosis | | 5 |
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Angiectasis | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 57 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Inflammation, Chronic | | 7 1.1|
Ulcer | | 4 1.5|
Mucosa, Hyperplasia | | 4 1.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
Erosion | | 3 1.7|
Mineralization | | 2 1.0|
Pigmentation | | 2 2.0|
Mucosa, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + | 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 0| 3| 6| 7| 7| | |
DAY ON TEST | 0| 7| 2| 3| 2| 9| 1| 3| 2| 2| | |
| 7| 7| 8| 1| 8| 4| 8| 0| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Incisor, Dysplasia | 1 1 1 2 3 | 26 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | 1 | 2 1.0|
Focal Cellular Change | | 1 1.0|
Subcapsular, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M + | 55 |
Cyst | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + | 53 |
Cyst | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 57 |
Degeneration, Cystic | 2 | 5 1.8|
Follicular Cell, Hyperplasia | 2 2 3 3 2 | 18 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 4 |
Dilatation | 3 | 4 2.8|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Granuloma Sperm | 3 3 | 3 2.7|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 21 |
Degeneration, Cystic | 4 2 3 2 | 21 3.1|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Dilatation | 2 3 | 11 2.6|
Hemorrhage | 2 | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 0| 3| 6| 7| 7| | |
DAY ON TEST | 0| 7| 2| 3| 2| 9| 1| 3| 2| 2| | |
| 7| 7| 8| 1| 8| 4| 8| 0| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Degeneration | | 1 2.0|
Mineralization | | 1 2.0|
Germinal Epithelium, Degeneration | 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Inguinal, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 56 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Angiectasis | 2 | 13 1.8|
Hyperplasia, Lymphoid | 3 2 | 8 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 57 |
Depletion Cellular | 2 3 1 | 25 2.6|
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 1 3 2 | 11 2.1|
Hyperplasia, Lymphoid | 2 2 | 7 1.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 52 |
Cyst | 2 1 | 5 1.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Hair Follicle, Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 2 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 5 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05142-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 13:58:23
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 0| 3| 6| 7| 7| | |
DAY ON TEST | 0| 7| 2| 3| 2| 9| 1| 3| 2| 2| | |
| 7| 7| 8| 1| 8| 4| 8| 0| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | | 1 1.0|
Inflammation, Acute, Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 57 |
Atrophy, Focal | | 1 2.0|
Congestion | | 4 2.3|
Cyst | 2 | 1 2.0|
Nephropathy | 1 1 2 1 2 1 1 2 2 | 44 1.6|
Artery, Inflammation, Chronic | | 1 2.0|
Pelvis, Dilatation | 2 | 1 2.0|
Renal Tubule, Dilatation | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Ureter | + | 1 |
Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + | 3 |
Dilatation | 3 | 1 3.0|
Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Calculus Gross Observation, Multiple,| | |
Greater Than Five | | 1 |
Dilatation | 4 | 2 3.5|
Inflammation, Chronic | 3 4 3 2 3 | 37 2.4|
Artery, Inflammation, Chronic | | 1 2.0|
Transitional Epithelium, Hyperplasia | 2 2 1 3 | 17 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------