TDMS Study 05142-03 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
T-BUTYL ALCOHOL
NTP Experiment-Test: 05142-03 Report: PEIRPT05
Study Type: CHRONIC Date: 05/20/95
Route: DOSED WATER Time: 07:39:33
Facility: Southern Research Institute
Chemical CAS #: 75-65-0
Lock Date: 01/10/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05142-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 07:39:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.25% 0.50% 1.00%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Natural Death 7 8 7 3
Moribund Sacrifice 15 18 21 35
Survivors
Terminal Sacrifice 28 24 22 12
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (60) (60) (59) (60)
Intestine Small, Jejunum (60) (59) (59) (60)
Adenoma 1 (2%)
Liver (60) (60) (60) (60)
Fibrosarcoma 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%) 1 (2%)
Mesentery (9) (6) (8) (6)
Carcinoma, Metastatic, Uterus 1 (13%)
Sarcoma Stromal, Metastatic, Uterus 1 (13%)
Pancreas (60) (60) (59) (60)
Carcinoma, Metastatic, Uterus 1 (2%)
Pharynx (1)
Squamous Cell Papilloma 1 (100%)
Salivary Glands (60) (60) (60) (60)
Stomach, Forestomach (60) (60) (60) (60)
Stomach, Glandular (60) (60) (60) (60)
Carcinoid Tumor Benign 1 (2%)
Tongue (1) (1) (3)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%) 1 (33%)
Tooth (2)
Gingiva, Squamous Cell Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05142-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 07:39:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.25% 0.50% 1.00%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Adrenal Medulla (60) (60) (60) (59)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 3 (5%) 1 (2%) 2 (3%)
Islets, Pancreatic (60) (60) (58) (60)
Adenoma 1 (2%) 1 (2%) 4 (7%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (60) (60) (59) (59)
Pars Distalis, Adenoma 33 (55%) 32 (53%) 28 (47%) 30 (51%)
Pars Distalis, Carcinoma 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (59) (60) (60) (60)
C-Cell, Adenoma 8 (14%) 4 (7%) 6 (10%) 9 (15%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (59) (60) (60) (60)
Adenoma 4 (7%) 6 (10%) 4 (7%) 2 (3%)
Carcinoma 3 (5%) 2 (3%) 6 (10%) 4 (7%)
Ovary (60) (60) (60) (60)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Granulosa-Theca Tumor Benign 1 (2%)
Uterus (60) (60) (60) (60)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (2%)
Carcinoma In Situ 1 (2%)
Hemangiosarcoma 1 (2%)
Leiomyoma 1 (2%) 1 (2%)
Polyp Stromal 14 (23%) 6 (10%) 9 (15%) 7 (12%)
Sarcoma Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05142-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 07:39:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.25% 0.50% 1.00%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Lymph Node (14) (15) (12) (7)
Lymph Node, Mandibular (60) (59) (60) (59)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Lymph Node, Mesenteric (60) (59) (60) (60)
Spleen (60) (60) (60) (60)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Thymus (58) (57) (59) (58)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (59) (60) (60)
Adenoma 2 (3%) 1 (2%) 2 (3%) 1 (2%)
Carcinoma 6 (10%) 5 (8%) 1 (2%) 1 (2%)
Fibroadenoma 14 (23%) 15 (25%) 11 (18%) 8 (13%)
Skin (60) (60) (59) (60)
Basal Cell Adenoma 1 (2%)
Keratoacanthoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (3%) 3 (5%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (1)
Squamous Cell Carcinoma, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 2 (3%)
Alveolar/Bronchiolar Adenoma, Multiple, Two 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Page 4
NTP Experiment-Test: 05142-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 07:39:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.25% 0.50% 1.00%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Fibrosarcoma, Metastatic, Skin 1 (2%) 1 (2%)
Nose (60) (60) (60) (60)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2) (1) (1)
Carcinoma 2 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Urinary Bladder (60) (60) (60) (60)
Carcinoma, Metastatic, Uterus 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Mononuclear 22 (37%) 20 (33%) 19 (32%) 14 (23%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05142-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 07:39:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.25% 0.50% 1.00%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 54 51 48 50
Total Primary Neoplasms 130 108 108 92
Total Animals with Benign Neoplasms 48 45 40 39
Total Benign Neoplasms 87 71 72 69
Total Animals with Malignant Neoplasms 33 31 29 22
Total Malignant Neoplasms 43 37 36 23
Total Animals with Metastatic Neoplasms 2 1 2 1
Total Metastatic Neoplasm 3 4 5 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05142-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 07:39:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.125% 0.25% 0.50%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 31 35 41 46
Natural Death 9 9 5 3
Survivors
Terminal Sacrifice 10 6 4 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (59) (60) (60)
Intestine Large, Rectum (59) (58) (59) (60)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Intestine Large, Cecum (60) (59) (60) (60)
Intestine Small, Duodenum (58) (53) (55) (60)
Intestine Small, Jejunum (60) (57) (60) (60)
Intestine Small, Ileum (60) (58) (59) (60)
Liver (60) (60) (60) (60)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (5) (7) (9) (3)
Carcinoma, Metastatic, Pancreas 1 (11%)
Fibrosarcoma, Metastatic, Skin 1 (33%)
Hemangiosarcoma 1 (11%)
Pancreas (60) (59) (60) (60)
Carcinoma 1 (2%) 1 (2%)
Acinar Cell, Adenoma 3 (5%) 6 (10%) 1 (2%) 1 (2%)
Stomach, Forestomach (60) (60) (60) (60)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (60) (59) (60) (60)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
Tooth (1)
Fibrosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05142-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 07:39:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.125% 0.25% 0.50%
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Schwannoma Benign 1 (2%)
Thymoma Malignant, Metastatic, Thymus 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Adenoma 1 (2%)
Carcinoma, Metastatic, Pancreas 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Adrenal Medulla (60) (60) (60) (60)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Ganglioneuroma 1 (2%)
Pheochromocytoma Malignant 4 (7%) 1 (2%) 2 (3%)
Pheochromocytoma Benign 9 (15%) 6 (10%) 4 (7%) 4 (7%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (60) (59) (59) (59)
Adenoma 15 (25%) 15 (25%) 7 (12%) 6 (10%)
Carcinoma 2 (3%) 2 (3%)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Pituitary Gland (59) (60) (59) (58)
Pars Distalis, Adenoma 39 (66%) 38 (63%) 35 (59%) 27 (47%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (60) (59) (60) (60)
C-Cell, Adenoma 5 (8%) 5 (8%) 1 (2%) 5 (8%)
C-Cell, Carcinoma 1 (2%) 2 (3%) 1 (2%)
Follicular Cell, Adenoma 2 (3%)
Follicular Cell, Carcinoma 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (60) (60)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Preputial Gland (60) (60) (60) (59)
Adenoma 2 (3%) 1 (2%) 1 (2%) 2 (3%)
Carcinoma 1 (2%) 3 (5%) 3 (5%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Page 8
NTP Experiment-Test: 05142-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 07:39:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.125% 0.25% 0.50%
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Prostate (60) (60) (60) (60)
Seminal Vesicle (60) (60) (60) (60)
Testes (60) (60) (60) (60)
Bilateral, Interstitial Cell, Adenoma 23 (38%) 17 (28%) 19 (32%) 24 (40%)
Interstitial Cell, Adenoma 15 (25%) 17 (28%) 20 (33%) 16 (27%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Lymph Node (19) (11) (15) (20)
Mediastinal, Carcinoma, Metastatic, Pancreas 1 (7%)
Pancreatic, Carcinoma, Metastatic, Islets,
Pancreatic 1 (7%)
Lymph Node, Mandibular (60) (58) (59) (60)
Lymph Node, Mesenteric (59) (59) (60) (60)
Spleen (60) (59) (60) (60)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Thymus (54) (59) (57) (56)
Thymoma Benign 1 (2%) 2 (4%)
Thymoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (54) (58) (57) (56)
Fibroadenoma 1 (2%) 2 (3%) 1 (2%)
Skin (60) (60) (59) (60)
Basal Cell Adenoma 2 (3%)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Keratoacanthoma 2 (3%) 2 (3%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 3 (5%) 3 (5%) 2 (3%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 3 (5%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Chordoma 1 (2%)
Skeletal Muscle (1) (1) (1)
Carcinoma, Metastatic, Pancreas 1 (100%)
Chordoma, Metastatic, Bone 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05142-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 07:39:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.125% 0.25% 0.50%
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Oligodendroglioma Benign 1 (2%)
Spinal Cord (1) (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Carcinoma, Metastatic, Pancreas 1 (2%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%) 1 (2%)
Chordoma, Metastatic, Bone 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Thymoma Malignant, Metastatic, Thymus 1 (2%)
Nose (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Bilateral, Renal Tubule, Adenoma, Multiple 1 (2%)
Renal Tubule, Adenoma 1 (2%) 3 (5%) 4 (7%) 2 (3%)
Renal Tubule, Carcinoma 1 (2%)
Renal Tubule, Oncocytoma Benign 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
Urinary Bladder (60) (60) (60) (60)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 30 (50%) 28 (47%) 24 (40%) 25 (42%)
Lymphoma Malignant Mixed 1 (2%)
Mesothelioma Benign 1 (2%)
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05142-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 07:39:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.125% 0.25% 0.50%
CONTROL
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(60) *(60) *(60) *(60)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05142-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYL ALCOHOL Date: 05/20/95
Route: DOSED WATER Time: 07:39:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.125% 0.25% 0.50%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 59 57 59 59
Total Primary Neoplasms 170 159 143 131
Total Animals with Benign Neoplasms 57 55 58 56
Total Benign Neoplasms 126 120 106 96
Total Animals with Malignant Neoplasms 38 33 32 30
Total Malignant Neoplasms 44 39 37 35
Total Animals with Metastatic Neoplasms 2 1 3 4
Total Metastatic Neoplasm 6 1 12 11
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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