TDMS Study 05142-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst T-BUTYL ALCOHOL DATE: 05/20/95
EXPERIMENT: 05142 TEST: 03 TIME: 07:57:17
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55121 ROUTE: DOSED WATER NTP C#: 55367B
PATHOLOGIST: DR J. HEATH S. EUSTIS CAS: 75-65-0
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst T-BUTYL ALCOHOL DATE: 05/20/95
EXPERIMENT: 05142 TEST: 03 TIME: 07:57:17
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55121 ROUTE: DOSED WATER NTP C#: 55367B
PATHOLOGIST: DR J. HEATH S. EUSTIS CAS: 75-65-0
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst T-BUTYL ALCOHOL DATE: 05/20/95
EXPERIMENT: 05142 TEST: 03 TIME: 07:57:17
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55121 ROUTE: DOSED WATER NTP C#: 55367B
PATHOLOGIST: DR J. HEATH S. EUSTIS CAS: 75-65-0
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF T-BUTYL ALCOHOL
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma: Benign, Complex, Malignant, NOS
Islets, Pancreatic Adenoma
Carcinoma or Adenoma
Kidney: Renal Tubule Adenoma
Carcinoma or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Testes Adenoma
Thymus Thymoma Benign
Thymoma: Benign, Malignant, NOS
Thyroid Gland: Follicular Cell
Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Adenoma
Mammary Gland Carcinoma
Carcinoma or Adenoma
Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Uterus Polyp Stromal
Sarcoma Stromal or Polyp Stromal
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 7/60 (12%) 4/60 (7%) 4/60 (7%) | 3/60 (5%) 0/60 (0%) 1/60 (2%) 2/59 (3%) |
|ADJUSTED (b) | 44.7% 35.0% 55.2% 14.2% | 9.4% 0.0% 4.5% 11.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/10 (20%) 0/6 (0%) 2/4 (50%) 0/1 (0%) | 2/28 (7%) 0/24 (0%) 1/22 (5%) 1/12 (8%) |
|FIRST INCIDENCE (DAYS) | 588 584 637 506 | 591 --- 729 (T) 617 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.545N P=0.442N P=0.446N P=0.568N | P=0.484 P=0.146N P=0.384N P=0.641 |
|INCIDENTAL TUMOR | P=0.106N P=0.284N P=0.240N P=0.143N | P=0.587 P=0.141N P=0.411N P=0.611N |
|LOGISTIC REGRESSION | P=0.188N P=0.385N P=0.265N P=0.213N | P=0.598 P=0.131N P=0.333N P=0.586N |
|COCHRAN-ARMITAGE | P=0.073N | P=0.562N |
|FISHER EXACT | P=0.395N P=0.120N P=0.120N | P=0.122N P=0.309N P=0.508N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 1/60 (2%) 2/60 (3%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 1/59 (2%) |
|ADJUSTED (b) | 24.9% 3.3% 26.7% 0.0% | 0.0% 4.2% 0.0% 1.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 2/10 (20%) 0/6 (0%) 1/4 (25%) 0/1 (0%) | 0/28 (0%) 1/24 (4%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 588 624 512 --- | --- 729 (T) --- 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.182N P=0.223N P=0.586N P=0.251N | P=0.324 P=0.469 (e) P=0.500 |
|INCIDENTAL TUMOR | P=0.107N P=0.272N P=0.461N P=0.154N | P=0.324 P=0.469 (e) P=0.500 |
|LOGISTIC REGRESSION | P=0.081N P=0.177N P=0.435N P=0.119N | P=0.407 P=0.469 (e) P=0.517 |
|COCHRAN-ARMITAGE | P=0.053N | P=0.401 |
|FISHER EXACT | P=0.182N P=0.340N P=0.059N | P=0.500 (e) P=0.496 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/60 (20%) 7/60 (12%) 6/60 (10%) 4/60 (7%) | 3/60 (5%) 1/60 (2%) 2/60 (3%) 3/59 (5%) |
|ADJUSTED (b) | 60.0% 35.0% 78.1% 14.2% | 9.4% 4.2% 6.9% 12.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 4/10 (40%) 0/6 (0%) 3/4 (75%) 0/1 (0%) | 2/28 (7%) 1/24 (4%) 1/22 (5%) 1/12 (8%) |
|FIRST INCIDENCE (DAYS) | 588 584 512 506 | 591 729 (T) 565 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.436N P=0.231N P=0.496N P=0.431N | P=0.292 P=0.355N P=0.587N P=0.458 |
|INCIDENTAL TUMOR | P=0.064N P=0.122N P=0.241N P=0.073N | P=0.411 P=0.348N P=0.638N P=0.575 |
|LOGISTIC REGRESSION | P=0.087N P=0.142N P=0.250N P=0.084N | P=0.441 P=0.331N P=0.526N P=0.637 |
|COCHRAN-ARMITAGE | P=0.024N* | P=0.469 |
|FISHER EXACT | P=0.159N P=0.100N P=0.029N* | P=0.309N P=0.500N P=0.652 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 1/60 (2%) 2/59 (3%) | 4/59 (7%) 6/60 (10%) 4/60 (7%) 2/60 (3%) |
|ADJUSTED (b) | 13.9% 2.8% 3.1% 100.0% | 13.1% 19.4% 18.2% 7.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 0/6 (0%) 0/4 (0%) 1/1 (100%) | 2/27 (7%) 3/24 (13%) 4/22 (18%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 636 596 582 575 | 645 457 (I) 729 (T) 597 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.297 P=0.531N P=0.628N P=0.308 | P=0.450N P=0.313 P=0.550 P=0.571N |
|INCIDENTAL TUMOR | P=0.423 P=0.589N P=0.602N P=0.397 | P=0.247N P=0.334 P=0.634 P=0.276N |
|LOGISTIC REGRESSION | P=0.456 P=0.498N P=0.573N P=0.509 | P=0.241N P=0.353 P=0.610 P=0.403N |
|COCHRAN-ARMITAGE | P=0.549 | P=0.185N |
|FISHER EXACT | P=0.500N P=0.500N P=0.684 | P=0.382 P=0.632N P=0.332N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/60 (5%) 3/60 (5%) 1/59 (2%) | 3/59 (5%) 2/60 (3%) 6/60 (10%) 4/60 (7%) |
|ADJUSTED (b) | 2.2% 7.0% 13.0% 1.7% | 10.6% 6.6% 24.4% 21.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 2/27 (7%) 1/24 (4%) 4/22 (18%) 1/12 (8%) |
|FIRST INCIDENCE (DAYS) | 553 348 589 262 | 723 591 699 610 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.576N P=0.331 P=0.264 P=0.758N | P=0.073 P=0.548N P=0.162 P=0.192 |
|INCIDENTAL TUMOR | P=0.409N P=0.270 P=0.303 P=0.736N | P=0.264 P=0.532N P=0.257 P=0.492 |
|LOGISTIC REGRESSION | P=0.498N P=0.273 P=0.289 P=0.723 | P=0.181 P=0.523N P=0.197 P=0.342 |
|COCHRAN-ARMITAGE | P=0.507N | P=0.317 |
|FISHER EXACT | P=0.309 P=0.309 P=0.748 | P=0.492N P=0.254 P=0.509 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 4/60 (7%) 3/59 (5%) | 7/59 (12%) 8/60 (13%) 10/60 (17%) 6/60 (10%) |
|ADJUSTED (b) | 15.8% 7.0% 15.7% 100.0% | 22.8% 25.2% 41.2% 27.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 0/6 (0%) 0/4 (0%) 1/1 (100%) | 4/27 (15%) 4/24 (17%) 8/22 (36%) 1/12 (8%) |
|FIRST INCIDENCE (DAYS) | 553 348 582 262 | 645 457 (I) 699 597 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.338 P=0.647 P=0.379 P=0.355 | P=0.211 P=0.417 P=0.176 P=0.321 |
|INCIDENTAL TUMOR | P=0.531 P=0.581 P=0.432 P=0.443 | P=0.534N P=0.448 P=0.297 P=0.463N |
|LOGISTIC REGRESSION | P=0.557 P=0.657 P=0.445 P=0.656 | P=0.523 P=0.470 P=0.237 P=0.583 |
|COCHRAN-ARMITAGE | P=0.548 | P=0.424N |
|FISHER EXACT | P=0.660N P=0.500 P=0.652 | P=0.514 P=0.314 P=0.487N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/60 (25%) 15/59 (25%) 7/59 (12%) 6/59 (10%) | 1/60 (2%) 1/60 (2%) 4/58 (7%) 1/60 (2%) |
|ADJUSTED (b) | 68.0% 66.3% 51.4% 29.0% | 3.4% 4.0% 18.0% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/10 (40%) 1/6 (17%) 1/4 (25%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 3/21 (14%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 604 520 556 555 | 723 727 724 666 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.438N P=0.477 P=0.392N P=0.568N | P=0.261 P=0.735 P=0.114 P=0.637 |
|INCIDENTAL TUMOR | P=0.012N* P=0.400N P=0.109N P=0.044N* | P=0.537 P=0.769 P=0.187 P=0.640N |
|LOGISTIC REGRESSION | P=0.051N P=0.574N P=0.144N P=0.131N | P=0.351 P=0.742 P=0.120 P=0.710 |
|COCHRAN-ARMITAGE | P=0.009N** | P=0.524 |
|FISHER EXACT | P=0.563 P=0.053N P=0.029N* | P=0.752N P=0.172 P=0.752N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/59 (0%) 2/59 (3%) 0/59 (0%) | 1/60 (2%) 0/60 (0%) 0/58 (0%) 0/60 (0%) |
|ADJUSTED (b) | 13.9% 0.0% 6.3% 0.0% | 3.6% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 1/28 (4%) 0/24 (0%) 0/21 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 636 --- 542 --- | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.407N P=0.285N P=0.582 P=0.499N | P=0.398N P=0.531N P=0.557N P=0.669N |
|INCIDENTAL TUMOR | P=0.289N P=0.312N P=0.698N P=0.399N | P=0.398N P=0.531N P=0.557N P=0.669N |
|LOGISTIC REGRESSION | P=0.288N P=0.240N P=0.649 P=0.392N | P=0.398N P=0.531N P=0.557N P=0.669N |
|COCHRAN-ARMITAGE | P=0.251N | P=0.307N |
|FISHER EXACT | P=0.252N P=0.684 P=0.252N | P=0.500N P=0.508N P=0.500N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/60 (28%) 15/59 (25%) 9/59 (15%) 6/59 (10%) | 2/60 (3%) 1/60 (2%) 4/58 (7%) 1/60 (2%) |
|ADJUSTED (b) | 74.5% 66.3% 54.5% 29.0% | 6.9% 4.0% 18.0% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/10 (50%) 1/6 (17%) 1/4 (25%) 0/1 (0%) | 1/28 (4%) 0/24 (0%) 3/21 (14%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 604 520 542 555 | 723 727 724 666 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.368N P=0.538N P=0.450N P=0.466N | P=0.404 P=0.543N P=0.226 P=0.714N |
|INCIDENTAL TUMOR | P=0.007N** P=0.264N P=0.125N P=0.023N* | P=0.533N P=0.518N P=0.327 P=0.469N |
|LOGISTIC REGRESSION | P=0.028N* P=0.387N P=0.167N P=0.066N | P=0.509 P=0.535N P=0.241 P=0.622N |
|COCHRAN-ARMITAGE | P=0.004N** | P=0.502N |
|FISHER EXACT | P=0.440N P=0.066N P=0.011N* | P=0.500N P=0.324 P=0.500N |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/60 (5%) 4/60 (7%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 10.0% 40.0% 34.9% 24.3% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 2/6 (33%) 0/4 (0%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 708 605 566 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.018 * P=0.160 P=0.061 P=0.091 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.131 P=0.206 P=0.127 P=0.206 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.094 P=0.188 P=0.093 P=0.215 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.283 | (e) |
|FISHER EXACT | P=0.309 P=0.182 P=0.309 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/60 (5%) 4/60 (7%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 10.0% 40.0% 34.9% 24.3% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 2/6 (33%) 0/4 (0%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 708 605 566 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.018 * P=0.160 P=0.061 P=0.091 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.131 P=0.206 P=0.127 P=0.206 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.094 P=0.188 P=0.093 P=0.215 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.283 | (e) |
|FISHER EXACT | P=0.309 P=0.182 P=0.309 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 10.0% 0.0% 25.0% 0.0% | 0.0% 0.0% 4.5% 10.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 0/6 (0%) 1/4 (25%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 1/22 (5%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) --- | --- --- 729 (T) 605 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.691 P=0.602N P=0.546 P=0.923N | P=0.029 * (e) P=0.452 P=0.159 |
|INCIDENTAL TUMOR | P=0.691 P=0.602N P=0.546 P=0.923N | P=0.094 (e) P=0.452 P=0.377 |
|LOGISTIC REGRESSION | P=0.691 P=0.602N P=0.546 P=0.923N | P=0.052 (e) P=0.452 P=0.211 |
|COCHRAN-ARMITAGE | P=0.405N | P=0.070 |
|FISHER EXACT | P=0.500N P=0.752N P=0.500N | (e) P=0.500 P=0.248 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 1/60 (2%) 1/60 (2%) | 0/60 (0%) 1/60 (2%) 2/60 (3%) 2/60 (3%) |
|ADJUSTED (b) | 10.0% 0.0% 25.0% 12.5% | 0.0% 4.2% 6.3% 10.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 0/6 (0%) 1/4 (25%) 0/1 (0%) | 0/28 (0%) 1/24 (4%) 1/22 (5%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) 669 | --- 729 (T) 457 (I) 605 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.154 P=0.602N P=0.546 P=0.426 | P=0.076 P=0.469 P=0.213 P=0.159 |
|INCIDENTAL TUMOR | P=0.223 P=0.602N P=0.546 P=0.591 | P=0.155 P=0.469 P=0.213 P=0.377 |
|LOGISTIC REGRESSION | P=0.199 P=0.602N P=0.546 P=0.528 | P=0.149 P=0.469 P=0.246 P=0.211 |
|COCHRAN-ARMITAGE | P=0.539 | P=0.160 |
|FISHER EXACT | P=0.500N P=0.752N P=0.752N | P=0.500 P=0.248 P=0.248 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 1/60 (2%) 2/60 (3%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 7.1% 4.2% 6.8% 3.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 2/28 (7%) 1/24 (4%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 729 (T) 729 (T) 694 631 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.578 P=0.554N P=0.646 P=0.720N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.456N P=0.554N P=0.645N P=0.620N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.538N P=0.554N P=0.663 P=0.594N |
|COCHRAN-ARMITAGE | (e) | P=0.444N |
|FISHER EXACT | (e) (e) (e) | P=0.500N P=0.691N P=0.500N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 6/60 (10%) 5/60 (8%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 18.9% 18.4% 4.2% 3.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 3/28 (11%) 3/24 (13%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 625 646 708 636 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.083N P=0.588N P=0.098N P=0.226N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.015N* P=0.560N P=0.046N* P=0.052N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.034N* P=0.559N P=0.072N P=0.102N |
|COCHRAN-ARMITAGE | (e) | P=0.019N* |
|FISHER EXACT | (e) (e) (e) | P=0.500N P=0.057N P=0.057N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 8/60 (13%) 5/60 (8%) 3/60 (5%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 25.4% 18.4% 10.7% 7.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 5/28 (18%) 3/24 (13%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 625 646 694 631 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.145N P=0.371N P=0.169N P=0.255N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.020N* P=0.338N P=0.067N P=0.058N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.013N* P=0.330N P=0.126N P=0.096N |
|COCHRAN-ARMITAGE | (e) | P=0.028N* |
|FISHER EXACT | (e) (e) (e) | P=0.279N P=0.102N P=0.047N* |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/60 (3%) 1/60 (2%) 0/60 (0%) | 14/60 (23%) 15/60 (25%) 11/60 (18%) 8/60 (13%) |
|ADJUSTED (b) | 8.3% 25.0% 2.3% 0.0% | 34.5% 47.5% 40.8% 32.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 1/6 (17%) 0/4 (0%) 0/1 (0%) | 4/28 (14%) 9/24 (38%) 7/22 (32%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 720 708 525 --- | 457 (I) 457 (I) 652 610 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.613N P=0.375 P=0.635 P=0.944N | P=0.432N P=0.375 P=0.477N P=0.447N |
|INCIDENTAL TUMOR | P=0.326N P=0.556 P=0.647N P=0.467N | P=0.045N* P=0.451 P=0.321N P=0.019N* |
|LOGISTIC REGRESSION | P=0.377N P=0.424 P=0.743 P=0.856N | P=0.106N P=0.450 P=0.390N P=0.151N |
|COCHRAN-ARMITAGE | P=0.248N | P=0.063N |
|FISHER EXACT | P=0.500 P=0.752N P=0.500N | P=0.500 P=0.327N P=0.119N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/60 (3%) 1/60 (2%) 0/60 (0%) | 16/60 (27%) 15/60 (25%) 11/60 (18%) 9/60 (15%) |
|ADJUSTED (b) | 8.3% 25.0% 2.3% 0.0% | 40.0% 47.5% 40.8% 35.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 1/6 (17%) 0/4 (0%) 0/1 (0%) | 6/28 (21%) 9/24 (38%) 7/22 (32%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 720 708 525 --- | 457 (I) 457 (I) 652 610 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.613N P=0.375 P=0.635 P=0.944N | P=0.420N P=0.518 P=0.338N P=0.445N |
|INCIDENTAL TUMOR | P=0.326N P=0.556 P=0.647N P=0.467N | P=0.040N* P=0.560N P=0.197N P=0.019N* |
|LOGISTIC REGRESSION | P=0.377N P=0.424 P=0.743 P=0.856N | P=0.091N P=0.559N P=0.242N P=0.123N |
|COCHRAN-ARMITAGE | P=0.248N | P=0.052N |
|FISHER EXACT | P=0.500 P=0.752N P=0.500N | P=0.500N P=0.191N P=0.088N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/60 (3%) 1/60 (2%) 0/60 (0%) | 19/60 (32%) 17/60 (28%) 12/60 (20%) 10/60 (17%) |
|ADJUSTED (b) | 8.3% 25.0% 2.3% 0.0% | 48.2% 52.6% 43.3% 37.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 1/6 (17%) 0/4 (0%) 0/1 (0%) | 9/28 (32%) 10/24 (42%) 7/22 (32%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 720 708 525 --- | 457 (I) 457 (I) 652 610 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.613N P=0.375 P=0.635 P=0.944N | P=0.346N P=0.564 P=0.241N P=0.398N |
|INCIDENTAL TUMOR | P=0.326N P=0.556 P=0.647N P=0.467N | P=0.018N* P=0.503N P=0.107N P=0.013N* |
|LOGISTIC REGRESSION | P=0.377N P=0.424 P=0.743 P=0.856N | P=0.048N* P=0.494N P=0.142N P=0.072N |
|COCHRAN-ARMITAGE | P=0.248N | P=0.023N* |
|FISHER EXACT | P=0.500 P=0.752N P=0.500N | P=0.421N P=0.105N P=0.043N* |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 1/60 (2%) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 10.0% 0.0% 0.0% 3.3% | 0.0% 4.0% 0.0% 5.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- 594 | --- 727 --- 597 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.394 P=0.602N P=0.682N P=0.541 | P=0.098 P=0.477 (e) P=0.216 |
|INCIDENTAL TUMOR | P=0.455 P=0.602N P=0.682N P=0.606 | P=0.285 P=0.500 (e) P=0.389 |
|LOGISTIC REGRESSION | P=0.505 P=0.602N P=0.682N P=0.674 | P=0.132 P=0.480 (e) P=0.241 |
|COCHRAN-ARMITAGE | P=0.595 | P=0.140 |
|FISHER EXACT | P=0.500N P=0.500N P=0.752N | P=0.500 (e) P=0.248 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 1/60 (2%) | 0/60 (0%) 2/60 (3%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 10.0% 0.0% 0.0% 3.3% | 0.0% 7.4% 3.0% 5.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- 594 | --- 703 651 597 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.394 P=0.602N P=0.682N P=0.541 | P=0.163 P=0.224 P=0.506 P=0.216 |
|INCIDENTAL TUMOR | P=0.455 P=0.602N P=0.682N P=0.606 | P=0.453 P=0.231 P=0.607 P=0.389 |
|LOGISTIC REGRESSION | P=0.505 P=0.602N P=0.682N P=0.674 | P=0.224 P=0.217 P=0.493 P=0.241 |
|COCHRAN-ARMITAGE | P=0.595 | P=0.246 |
|FISHER EXACT | P=0.500N P=0.500N P=0.752N | P=0.248 P=0.500 P=0.248 |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 6/59 (10%) 1/60 (2%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) |
|ADJUSTED (b) | 22.9% 63.3% 16.7% 2.6% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 3/6 (50%) 0/4 (0%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 694 693 685 575 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.456 P=0.111 P=0.667N P=0.683 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.253N P=0.250 P=0.381N P=0.395N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.434N P=0.156 P=0.571N P=0.524N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.095N | (e) |
|FISHER EXACT | P=0.237 P=0.309N P=0.309N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pancreas |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 7/59 (12%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) |
|ADJUSTED (b) | 22.9% 64.8% 18.9% 2.6% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 3/6 (50%) 0/4 (0%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 694 639 551 575 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.488 P=0.073 P=0.527 P=0.683 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.219N P=0.156 P=0.580N P=0.395N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.330N P=0.108 P=0.652N P=0.524N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.096N | (e) |
|FISHER EXACT | P=0.154 P=0.500N P=0.309N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 39/59 (66%) 38/60 (63%) 35/59 (59%) 27/58 (47%) | 33/60 (55%) 32/60 (53%) 28/59 (47%) 30/59 (51%) |
|ADJUSTED (b) | 93.2% 96.3% 100.0% 93.5% | 79.3% 80.6% 74.2% 92.2% |
|INTERIM SACRIFICE 1 (c)| 6/10 (60%) 5/10 (50%) 4/10 (40%) 4/9 (44%) | 3/10 (30%) 3/10 (30%) 2/10 (20%) 3/10 (30%) |
|TERMINAL (d) | 7/9 (78%) 5/6 (83%) 4/4 (100%) 0/1 (0%) | 20/28 (71%) 17/24 (71%) 13/22 (59%) 10/12 (83%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 395 398 456 (I) | 457 (I) 424 377 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.174 P=0.520 P=0.190 P=0.337 | P=0.035 * P=0.385 P=0.559N P=0.031 * |
|INCIDENTAL TUMOR | P=0.027N* P=0.436N P=0.367N P=0.033N* | P=0.513 P=0.534 P=0.305N P=0.437 |
|LOGISTIC REGRESSION | P=0.021N* P=0.416N P=0.353N P=0.033N* | P=0.439N P=0.547 P=0.350N P=0.538N |
|COCHRAN-ARMITAGE | P=0.014N* | P=0.332N |
|FISHER EXACT | P=0.451N P=0.284N P=0.026N* | P=0.500N P=0.261N P=0.394N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/59 (2%) 0/60 (0%) 0/59 (0%) 0/58 (0%) | 2/60 (3%) 1/60 (2%) 1/59 (2%) 1/59 (2%) |
|ADJUSTED (b) | 4.8% 0.0% 0.0% 0.0% | 5.0% 3.0% 3.8% 2.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/9 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 645 --- --- --- | 457 (I) 624 703 555 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.364N P=0.473N P=0.567N P=0.581N | P=0.480N P=0.524N P=0.520N P=0.562N |
|INCIDENTAL TUMOR | P=0.305N P=0.402N P=0.500N P=0.467N | P=0.254N P=0.500N P=0.376N P=0.366N |
|LOGISTIC REGRESSION | P=0.335N P=0.493N P=0.536N P=0.554N | P=0.411N P=0.488N P=0.504N P=0.489N |
|COCHRAN-ARMITAGE | P=0.308N | P=0.416N |
|FISHER EXACT | P=0.496N P=0.500N P=0.504N | P=0.500N P=0.506N P=0.506N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 39/59 (66%) 38/60 (63%) 35/59 (59%) 27/58 (47%) | 35/60 (58%) 33/60 (55%) 29/59 (49%) 31/59 (53%) |
|ADJUSTED (b) | 93.2% 96.3% 100.0% 93.5% | 80.4% 81.2% 75.2% 92.4% |
|INTERIM SACRIFICE 1 (c)| 6/10 (60%) 5/10 (50%) 4/10 (40%) 4/9 (44%) | 4/10 (40%) 3/10 (30%) 2/10 (20%) 3/10 (30%) |
|TERMINAL (d) | 7/9 (78%) 5/6 (83%) 4/4 (100%) 0/1 (0%) | 20/28 (71%) 17/24 (71%) 13/22 (59%) 10/12 (83%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 395 398 456 (I) | 457 (I) 424 377 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.174 P=0.520 P=0.190 P=0.337 | P=0.047 * P=0.444 P=0.501N P=0.045 * |
|INCIDENTAL TUMOR | P=0.027N* P=0.436N P=0.367N P=0.033N* | P=0.439N P=0.543N P=0.208N P=0.565 |
|LOGISTIC REGRESSION | P=0.021N* P=0.416N P=0.353N P=0.033N* | P=0.371N P=0.527N P=0.283N P=0.443N |
|COCHRAN-ARMITAGE | P=0.014N* | P=0.279N |
|FISHER EXACT | P=0.451N P=0.284N P=0.026N* | P=0.427N P=0.206N P=0.326N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 7.0% 0.0% | 0.0% 0.0% 0.0% 2.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 556 --- | --- --- --- 576 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.559 (e) P=0.221 (e) | P=0.207 (e) (e) P=0.500 |
|INCIDENTAL TUMOR | P=0.653 (e) P=0.237 (e) | P=0.310 (e) (e) P=0.630 |
|LOGISTIC REGRESSION | P=0.592 (e) P=0.234 (e) | P=0.201 (e) (e) P=0.510 |
|COCHRAN-ARMITAGE | P=0.595 | P=0.199 |
|FISHER EXACT | (e) P=0.248 (e) | (e) (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 5/60 (8%) 6/60 (10%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 14.1% 32.0% 43.4% 18.4% | 0.0% 0.0% 2.9% 6.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 1/6 (17%) 1/4 (25%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 588 591 456 (I) 555 | --- --- 645 576 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.224 P=0.328 P=0.109 P=0.414 | P=0.051 (e) P=0.494 P=0.199 |
|INCIDENTAL TUMOR | P=0.520N P=0.342 P=0.200 P=0.554N | P=0.157 (e) P=0.607 P=0.377 |
|LOGISTIC REGRESSION | P=0.511 P=0.359 P=0.195 P=0.607 | P=0.069 (e) P=0.494 P=0.237 |
|COCHRAN-ARMITAGE | P=0.517N | P=0.070 |
|FISHER EXACT | P=0.359 P=0.245 P=0.660N | (e) P=0.500 P=0.248 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/60 (5%) 1/60 (2%) 1/60 (2%) | 0/60 (0%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 6.7% 17.3% 2.2% 20.0% | 0.0% 4.2% 2.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 0/28 (0%) 1/24 (4%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 692 584 484 679 | --- 729 (T) 562 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.477 P=0.277 P=0.641 P=0.403 | P=0.672N P=0.469 P=0.486 (e) |
|INCIDENTAL TUMOR | P=0.398N P=0.369 P=0.647N P=0.727N | P=0.588N P=0.469 P=0.419 (e) |
|LOGISTIC REGRESSION | P=0.505N P=0.307 P=0.761 P=0.597 | P=0.604N P=0.469 P=0.518 (e) |
|COCHRAN-ARMITAGE | P=0.444N | P=0.595N |
|FISHER EXACT | P=0.309 P=0.752N P=0.752N | P=0.500 P=0.500 (e) |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 4/60 (7%) 2/60 (3%) 2/60 (3%) | 2/60 (3%) 4/60 (7%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 15.3% 19.2% 6.3% 22.0% | 7.1% 14.9% 2.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 2/28 (7%) 3/24 (13%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 553 562 484 566 | 729 (T) 610 562 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.546 P=0.466 P=0.662 P=0.502 | P=0.181N P=0.277 P=0.564N P=0.438N |
|INCIDENTAL TUMOR | P=0.242N P=0.572 P=0.408N P=0.408N | P=0.132N P=0.279 P=0.602N P=0.438N |
|LOGISTIC REGRESSION | P=0.363N P=0.504 P=0.526N P=0.601N | P=0.111N P=0.296 P=0.521N P=0.438N |
|COCHRAN-ARMITAGE | P=0.319N | P=0.087N |
|FISHER EXACT | P=0.500 P=0.500N P=0.500N | P=0.340 P=0.500N P=0.248N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 1/60 (2%) 1/60 (2%) | 2/60 (3%) 3/60 (5%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 9.2% 2.3% 4.2% 2.4% | 7.1% 10.8% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 2/28 (7%) 2/24 (8%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 553 562 623 566 | 729 (T) 610 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.539N P=0.512N P=0.639N P=0.679N | P=0.146N P=0.441 P=0.292N P=0.438N |
|INCIDENTAL TUMOR | P=0.333N P=0.475N P=0.500N P=0.422N | P=0.121N P=0.444 P=0.292N P=0.438N |
|LOGISTIC REGRESSION | P=0.423N P=0.499N P=0.536N P=0.520N | P=0.100N P=0.462 P=0.292N P=0.438N |
|COCHRAN-ARMITAGE | P=0.409N | P=0.073N |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | P=0.500 P=0.248N P=0.248N |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 19.6% 29.2% 2.3% | 0.0% 0.0% 2.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 1/6 (17%) 1/4 (25%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | --- 626 638 555 | --- --- 645 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.192 P=0.199 P=0.132 P=0.514 | P=0.658 (e) P=0.494 (e) |
|INCIDENTAL TUMOR | P=0.310 P=0.172 P=0.145 P=0.551 | P=0.734N (e) P=0.607 (e) |
|LOGISTIC REGRESSION | P=0.338 P=0.234 P=0.143 P=0.504 | P=0.690 (e) P=0.494 (e) |
|COCHRAN-ARMITAGE | P=0.470 | P=0.694 |
|FISHER EXACT | P=0.248 P=0.248 P=0.500 | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 14.1% 15.4% 14.1% 2.6% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 588 591 456 (I) 575 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.426N P=0.648 P=0.676N P=0.524N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.150N P=0.631N P=0.500N P=0.227N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.227N P=0.660N P=0.529N P=0.355N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.194N | (e) |
|FISHER EXACT | P=0.660N P=0.500N P=0.309N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 5/60 (8%) 4/60 (7%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 14.1% 32.0% 39.1% 18.4% | 0.0% 0.0% 2.9% 4.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 1/6 (17%) 1/4 (25%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 588 591 456 (I) 555 | --- --- 645 667 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.249 P=0.328 P=0.278 P=0.414 | P=0.175 (e) P=0.494 P=0.425 |
|INCIDENTAL TUMOR | P=0.511N P=0.342 P=0.434 P=0.554N | P=0.341 (e) P=0.607 P=0.607 |
|LOGISTIC REGRESSION | P=0.544 P=0.359 P=0.427 P=0.607 | P=0.224 (e) P=0.494 P=0.477 |
|COCHRAN-ARMITAGE | P=0.482N | P=0.236 |
|FISHER EXACT | P=0.359 P=0.500 P=0.660N | (e) P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 5/60 (8%) 4/60 (7%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 14.1% 32.0% 39.1% 4.8% | 0.0% 0.0% 2.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 1/6 (17%) 1/4 (25%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 588 591 456 (I) 555 | --- --- 645 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.442 P=0.328 P=0.278 P=0.674 | P=0.658 (e) P=0.494 (e) |
|INCIDENTAL TUMOR | P=0.345N P=0.342 P=0.434 P=0.392N | P=0.734N (e) P=0.607 (e) |
|LOGISTIC REGRESSION | P=0.418N P=0.359 P=0.427 P=0.537N | P=0.690 (e) P=0.494 (e) |
|COCHRAN-ARMITAGE | P=0.321N | P=0.694 |
|FISHER EXACT | P=0.359 P=0.500 P=0.500N | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 38/60 (63%) 34/60 (57%) 39/60 (65%) 40/60 (67%) | |
|ADJUSTED (b) | 96.7% 100.0% 96.7% 100.0% | |
|INTERIM SACRIFICE 1 (c)| 4/10 (40%) 3/10 (30%) 8/10 (80%) 7/10 (70%) | |
|TERMINAL (d) | 9/10 (90%) 6/6 (100%) 3/4 (75%) 1/1 (100%) | |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 456 (I) 456 (I) | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.492N P=0.048 * P=0.004 ** | |
|INCIDENTAL TUMOR | P=0.120 P=0.323N P=0.333 P=0.257 | |
|LOGISTIC REGRESSION | P=0.154 P=0.252N P=0.379 P=0.319 | |
|COCHRAN-ARMITAGE | P=0.271 | |
|FISHER EXACT | P=0.288N P=0.500 P=0.424 | |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thymus |
| Thymoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/54 (2%) 0/59 (0%) 0/57 (0%) 2/56 (4%) | 0/58 (0%) 0/57 (0%) 0/59 (0%) 0/58 (0%) |
|ADJUSTED (b) | 11.1% 0.0% 0.0% 100.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/9 (0%) 0/10 (0%) 0/9 (0%) 1/9 (11%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/9 (11%) 0/5 (0%) 0/4 (0%) 1/1 (100%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- 456 (I) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.047 * P=0.617N P=0.662N P=0.106 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.047 * P=0.617N P=0.662N P=0.106 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.199 P=0.617N P=0.662N P=0.444 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.246 | (e) |
|FISHER EXACT | P=0.478N P=0.486N P=0.514 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Thymus |
| Thymoma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/54 (2%) 1/59 (2%) 0/57 (0%) 3/56 (5%) | 0/58 (0%) 0/57 (0%) 0/59 (0%) 0/58 (0%) |
|ADJUSTED (b) | 11.1% 5.9% 0.0% 100.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/9 (0%) 0/10 (0%) 0/9 (0%) 1/9 (11%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/9 (11%) 0/5 (0%) 0/4 (0%) 1/1 (100%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 673 --- 274 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.024 * P=0.705 P=0.662N P=0.055 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.048 * P=0.761N P=0.662N P=0.055 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.164 P=0.762 P=0.662N P=0.321 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.160 | (e) |
|FISHER EXACT | P=0.730N P=0.486N P=0.323 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 5/59 (8%) 1/60 (2%) 5/60 (8%) | 8/59 (14%) 4/60 (7%) 6/60 (10%) 9/60 (15%) |
|ADJUSTED (b) | 34.2% 38.0% 4.8% 22.6% | 24.8% 12.0% 20.1% 38.2% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 1/10 (10%) 0/10 (0%) 1/10 (10%) | 1/9 (11%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/10 (30%) 2/6 (33%) 0/4 (0%) 0/1 (0%) | 6/28 (21%) 2/24 (8%) 2/22 (9%) 1/12 (8%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 637 456 (I) | 457 (I) 430 575 610 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.223 P=0.485 P=0.232N P=0.206 | P=0.069 P=0.242N P=0.510N P=0.125 |
|INCIDENTAL TUMOR | P=0.410 P=0.438 P=0.222N P=0.376 | P=0.341 P=0.189N P=0.445N P=0.486 |
|LOGISTIC REGRESSION | P=0.561 P=0.628N P=0.155N P=0.551 | P=0.239 P=0.191N P=0.434N P=0.375 |
|COCHRAN-ARMITAGE | P=0.497N | P=0.312 |
|FISHER EXACT | P=0.618 P=0.103N P=0.628N | P=0.173N P=0.376N P=0.515 |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/59 (3%) 0/60 (0%) 1/60 (2%) | 1/59 (2%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 3.2% 7.4% 0.0% 2.3% | 3.6% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 1/28 (4%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 603 629 --- 555 | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.591N P=0.533 P=0.528N P=0.731 | P=0.395N P=0.531N P=0.548N P=0.669N |
|INCIDENTAL TUMOR | P=0.407N P=0.453 P=0.500N P=0.704N | P=0.395N P=0.531N P=0.548N P=0.669N |
|LOGISTIC REGRESSION | P=0.516N P=0.500 P=0.508N P=0.762N | P=0.395N P=0.531N P=0.548N P=0.669N |
|COCHRAN-ARMITAGE | P=0.498N | P=0.304N |
|FISHER EXACT | P=0.494 P=0.500N P=0.752N | P=0.496N P=0.496N P=0.496N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 7/59 (12%) 1/60 (2%) 6/60 (10%) | 9/59 (15%) 4/60 (7%) 6/60 (10%) 9/60 (15%) |
|ADJUSTED (b) | 36.3% 42.6% 4.8% 24.4% | 28.3% 12.0% 20.1% 38.2% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 1/10 (10%) 0/10 (0%) 1/10 (10%) | 1/9 (11%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/10 (30%) 2/6 (33%) 0/4 (0%) 0/1 (0%) | 7/28 (25%) 2/24 (8%) 2/22 (9%) 1/12 (8%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 637 456 (I) | 457 (I) 430 575 610 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.271 P=0.387 P=0.148N P=0.219 | P=0.101 P=0.171N P=0.414N P=0.165 |
|INCIDENTAL TUMOR | P=0.533 P=0.306 P=0.133N P=0.420 | P=0.414 P=0.130N P=0.351N P=0.551 |
|LOGISTIC REGRESSION | P=0.515N P=0.502 P=0.089N P=0.556 | P=0.317 P=0.130N P=0.335N P=0.462 |
|COCHRAN-ARMITAGE | P=0.433N | P=0.403 |
|FISHER EXACT | P=0.487 P=0.057N P=0.619N | P=0.113N P=0.279N P=0.585N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/59 (0%) 0/60 (0%) 0/60 (0%) | 1/59 (2%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 5.9% 0.0% 0.0% 0.0% | 3.6% 0.0% 4.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 1/28 (4%) 0/24 (0%) 1/22 (5%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 573 --- --- --- | 729 (T) --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.132N P=0.224N P=0.268N P=0.274N | P=0.565N P=0.531N P=0.708 P=0.669N |
|INCIDENTAL TUMOR | P=0.095N P=0.267N P=0.237N P=0.183N | P=0.565N P=0.531N P=0.708 P=0.669N |
|LOGISTIC REGRESSION | P=0.115N P=0.243N P=0.239N P=0.239N | P=0.565N P=0.531N P=0.708 P=0.669N |
|COCHRAN-ARMITAGE | P=0.115N | P=0.402N |
|FISHER EXACT | P=0.252N P=0.248N P=0.248N | P=0.496N P=0.748N P=0.496N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/59 (0%) 0/60 (0%) 0/60 (0%) | 1/59 (2%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 8.4% 0.0% 0.0% 0.0% | 3.0% 0.0% 4.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 1/22 (5%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 623 --- --- --- | 650 --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.141N P=0.206N P=0.249N P=0.321N | P=0.510N P=0.526N P=0.734 P=0.564N |
|INCIDENTAL TUMOR | P=0.095N P=0.267N P=0.237N P=0.183N | P=0.414N P=0.500N P=0.732N P=0.393N |
|LOGISTIC REGRESSION | P=0.127N P=0.237N P=0.263N P=0.271N | P=0.440N P=0.503N P=0.747 P=0.509N |
|COCHRAN-ARMITAGE | P=0.115N | P=0.402N |
|FISHER EXACT | P=0.252N P=0.248N P=0.248N | P=0.496N P=0.748N P=0.496N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 0/59 (0%) 0/60 (0%) 0/60 (0%) | 2/59 (3%) 0/60 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 13.7% 0.0% 0.0% 0.0% | 6.5% 0.0% 9.1% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 1/28 (4%) 0/24 (0%) 2/22 (9%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | 573 --- --- --- | 650 --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.028N* P=0.053N P=0.078N P=0.104N | P=0.403N P=0.271N P=0.628 P=0.371N |
|INCIDENTAL TUMOR | P=0.014N* P=0.078N P=0.061N P=0.034N* | P=0.337N P=0.257N P=0.679 P=0.258N |
|LOGISTIC REGRESSION | P=0.022N* P=0.064N P=0.069N P=0.070N | P=0.317N P=0.251N P=0.664 P=0.282N |
|COCHRAN-ARMITAGE | P=0.020N* | P=0.244N |
|FISHER EXACT | P=0.061N P=0.059N P=0.059N | P=0.244N P=0.684N P=0.244N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 14/60 (23%) 6/60 (10%) 9/60 (15%) 7/60 (12%) |
|ADJUSTED (b) | | 39.1% 19.7% 26.3% 22.8% |
|INTERIM SACRIFICE 1 (c)| | 3/10 (30%) 1/10 (10%) 2/10 (20%) 1/10 (10%) |
|TERMINAL (d) | | 9/28 (32%) 3/24 (13%) 3/22 (14%) 1/12 (8%) |
|FIRST INCIDENCE (DAYS) | | 457 (I) 457 (I) 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.385N P=0.075N P=0.302N P=0.350N |
|INCIDENTAL TUMOR | | P=0.156N P=0.066N P=0.214N P=0.149N |
|LOGISTIC REGRESSION | | P=0.122N P=0.050N* P=0.190N P=0.085N |
|COCHRAN-ARMITAGE | | P=0.111N |
|FISHER EXACT | | P=0.042N* P=0.177N P=0.074N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 14/60 (23%) 6/60 (10%) 9/60 (15%) 7/60 (12%) |
|ADJUSTED (b) | | 39.1% 19.7% 26.3% 22.8% |
|INTERIM SACRIFICE 1 (c)| | 3/10 (30%) 1/10 (10%) 2/10 (20%) 1/10 (10%) |
|TERMINAL (d) | | 9/28 (32%) 3/24 (13%) 3/22 (14%) 1/12 (8%) |
|FIRST INCIDENCE (DAYS) | | 457 (I) 457 (I) 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.385N P=0.075N P=0.302N P=0.350N |
|INCIDENTAL TUMOR | | P=0.156N P=0.066N P=0.214N P=0.149N |
|LOGISTIC REGRESSION | | P=0.122N P=0.050N* P=0.190N P=0.085N |
|COCHRAN-ARMITAGE | | P=0.111N |
|FISHER EXACT | | P=0.042N* P=0.177N P=0.074N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 1/60 (2%) | 2/60 (3%) 1/60 (2%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 4.2% 2.2% | 5.2% 2.5% 0.0% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 1/28 (4%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 623 526 | 428 590 --- 591 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.199 (e) P=0.492 P=0.496 | P=0.412N P=0.527N P=0.274N P=0.591N |
|INCIDENTAL TUMOR | P=0.265 (e) P=0.500 P=0.500 | P=0.321N P=0.417N P=0.165N P=0.521N |
|LOGISTIC REGRESSION | P=0.238 (e) P=0.480 P=0.501 | P=0.357N P=0.484N P=0.222N P=0.484N |
|COCHRAN-ARMITAGE | P=0.236 | P=0.367N |
|FISHER EXACT | (e) P=0.500 P=0.500 | P=0.500N P=0.248N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.6% 0.0% | 0.0% 0.0% 4.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/6 (0%) 0/4 (0%) 0/1 (0%) | 0/28 (0%) 0/24 (0%) 0/22 (0%) 0/12 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 355 --- | --- --- 724 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.587 (e) P=0.232 (e) | P=0.614 (e) P=0.461 (e) |
|INCIDENTAL TUMOR | P=0.624 (e) P=0.240 (e) | P=0.734N (e) P=0.607 (e) |
|LOGISTIC REGRESSION | P=0.569 (e) P=0.203 (e) | P=0.637 (e) P=0.475 (e) |
|COCHRAN-ARMITAGE | P=0.595 | P=0.694 |
|FISHER EXACT | (e) P=0.248 (e) | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 30/60 (50%) 28/60 (47%) 24/60 (40%) 25/60 (42%) | 22/60 (37%) 20/60 (33%) 19/60 (32%) 14/60 (23%) |
|ADJUSTED (b) | 85.0% 85.1% 100.0% 78.4% | 54.4% 49.5% 53.5% 43.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%) |
|TERMINAL (d) | 6/10 (60%) 3/6 (50%) 4/4 (100%) 0/1 (0%) | 11/28 (39%) 5/24 (21%) 8/22 (36%) 2/12 (17%) |
|FIRST INCIDENCE (DAYS) | 288 553 510 456 (I) | 524 232 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.046 * P=0.524N P=0.299 P=0.132 | P=0.463N P=0.548 P=0.562 P=0.502N |
|INCIDENTAL TUMOR | P=0.215N P=0.401N P=0.255N P=0.225N | P=0.015N* P=0.420N P=0.498N P=0.046N* |
|LOGISTIC REGRESSION | P=0.373N P=0.400N P=0.325N P=0.329N | P=0.039N* P=0.468N P=0.496N P=0.026N* |
|COCHRAN-ARMITAGE | P=0.184N | P=0.063N |
|FISHER EXACT | P=0.428N P=0.179N P=0.232N | P=0.424N P=0.350N P=0.081N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 57/60 (95%) 55/60 (92%) 58/60 (97%) 56/60 (93%) | 48/60 (80%) 45/60 (75%) 40/60 (67%) 39/60 (65%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 97.9% 95.5% 92.8% 94.7% |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%) 8/10 (80%) 9/10 (90%) 9/10 (90%) | 5/10 (50%) 4/10 (40%) 2/10 (20%) 3/10 (30%) |
|TERMINAL (d) | 10/10 (100%) 6/6 (100%) 4/4 (100%) 1/1 (100%) | 27/28 (96%) 22/24 (92%) 19/22 (86%) 10/12 (83%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 395 343 456 (I) | 457 (I) 424 377 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.509 P=0.034 * P=0.006 ** | P=0.077 P=0.421 P=0.494N P=0.074 |
|INCIDENTAL TUMOR | P=0.581N P=0.282N P=0.500 P=0.549N | P=0.052N P=0.463N P=0.113N P=0.104N |
|LOGISTIC REGRESSION | P=0.568N P=0.279N P=0.612 P=0.493N | P=0.035N* P=0.471N P=0.148N P=0.062N |
|COCHRAN-ARMITAGE | P=0.537N | P=0.033N* |
|FISHER EXACT | P=0.359N P=0.500 P=0.500N | P=0.331N P=0.074N P=0.051N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.125% 0.25% 0.50% | VEHICLE 0.25% 0.50% 1.00% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 38/60 (63%) 33/60 (55%) 32/60 (53%) 30/60 (50%) | 33/60 (55%) 31/60 (52%) 29/60 (48%) 22/60 (37%) |
|ADJUSTED (b) | 93.9% 87.1% 100.0% 83.4% | 70.8% 72.8% 70.4% 61.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) | 1/10 (10%) 0/10 (0%) 3/10 (30%) 2/10 (20%) |
|TERMINAL (d) | 8/10 (80%) 3/6 (50%) 4/4 (100%) 0/1 (0%) | 15/28 (54%) 13/24 (54%) 11/22 (50%) 3/12 (25%) |
|FIRST INCIDENCE (DAYS) | 288 348 355 262 | 226 232 377 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.067 P=0.377N P=0.245 P=0.160 | P=0.528 P=0.469 P=0.531 P=0.545N |
|INCIDENTAL TUMOR | P=0.087N P=0.222N P=0.197N P=0.103N | P=0.004N** P=0.405N P=0.299N P=0.011N* |
|LOGISTIC REGRESSION | P=0.174N P=0.193N P=0.294N P=0.136N | P=0.029N* P=0.483N P=0.354N P=0.042N* |
|COCHRAN-ARMITAGE | P=0.098N | P=0.021N* |
|FISHER EXACT | P=0.229N P=0.177N P=0.099N | P=0.427N P=0.292N P=0.033N* |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 59/60 (98%) 57/60 (95%) 59/60 (98%) 59/60 (98%) | 54/60 (90%) 51/60 (85%) 48/60 (80%) 50/60 (83%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 100.0% 96.1% 97.9% 100.0% |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%) 8/10 (80%) 9/10 (90%) 9/10 (90%) | 6/10 (60%) 4/10 (40%) 5/10 (50%) 5/10 (50%) |
|TERMINAL (d) | 10/10 (100%) 6/6 (100%) 4/4 (100%) 1/1 (100%) | 28/28 (100%) 22/24 (92%) 21/22 (95%) 12/12 (100%)|
|FIRST INCIDENCE (DAYS) | 288 348 343 262 | 226 232 377 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.513 P=0.045 * P=0.005 ** | P=0.011 * P=0.410 P=0.476 P=0.013 * |
|INCIDENTAL TUMOR | P=0.442 P=0.289N P=0.760 P=0.760 | P=0.180N P=0.292N P=0.154N P=0.335N |
|LOGISTIC REGRESSION | P=0.512 P=0.134N P=0.557N P=0.642N | P=0.211N P=0.375N P=0.223N P=0.230N |
|COCHRAN-ARMITAGE | P=0.444 | P=0.190N |
|FISHER EXACT | P=0.309N P=0.752N P=0.752N | P=0.291N P=0.100N P=0.211N |
|=================================================================================================================================|
DATE: 05/20/95 EXPERIMENT: 05142 TEST: 03 PAGE 27
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYL ALCOHOL
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 456
Female interim sacrifices(days): 457
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).