TDMS Study 05142-03 Pathology Tables
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
Facility: Southern Research Institute
Chemical CAS #: 75-65-0
Lock Date: 01/10/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 4| 5| 7| 5| 4| 5| 7| 2| 6| 6| 5| 7| 4| 5| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 8| 5| 2| 2| 2| 8| 5| 9| 2| 2| 3| 8| 9| 2| 5| 5| 2| 2| 2| 5| 9| 2|
| 9| 9| 7| 0| 7| 8| 4| 9| 9| 7| 4| 9| 6| 7| 0| 1| 9| 7| 4| 9| 9| 9| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + I + +|
Parasite Metazoan | X X X X X X X X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Granuloma | 3 1 2 1 1 2 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X X X X X X |
Hyperplasia, Focal | 4 3 3 |
Hyperplasia, Lymphoid | 2 1 1 |
Inflammation, Subacute | 1 1 1 |
Mixed Cell Focus | X |
Bile Duct, Cyst | X X |
Bile Duct, Hyperplasia | 2 2 3 1 1 1|
Centrilobular, Atrophy | 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 2 3 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + |
Accessory Spleen | |
Fat, Necrosis | 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 2 1 1 1 1|
Acinar Cell, Cytoplasmic Alteration | 3 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Acinar Cell, Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Erosion | 1 |
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 4| 5| 7| 5| 4| 5| 7| 2| 6| 6| 5| 7| 4| 5| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 8| 5| 2| 2| 2| 8| 5| 9| 2| 2| 3| 8| 9| 2| 5| 5| 2| 2| 2| 5| 9| 2|
| 9| 9| 7| 0| 7| 8| 4| 9| 9| 7| 4| 9| 6| 7| 0| 1| 9| 7| 4| 9| 9| 9| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 3 |
Mucosa, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Edema | |
Erosion | 1 1 1 3 |
Ulcer | |
Epithelium, Dilatation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Angiectasis | 2 2 |
Atrophy | 3 |
Basophilic Focus | X |
Congestion | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Focal | 1 1|
Hypertrophy, Focal | |
Metaplasia, Osseous | 2 |
Necrosis | 3 |
Pigmentation | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 1 1 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
Pars Distalis, Angiectasis | 3 3 3 2 2 2 |
Pars Distalis, Atrophy | |
Pars Distalis, Cyst | X X X X X X X X X X X X X |
Pars Distalis, Hyperplasia | 2 3 1 3 2 2 1 2 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 4| 5| 7| 5| 4| 5| 7| 2| 6| 6| 5| 7| 4| 5| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 8| 5| 2| 2| 2| 8| 5| 9| 2| 2| 3| 8| 9| 2| 5| 5| 2| 2| 2| 5| 9| 2|
| 9| 9| 7| 0| 7| 8| 4| 9| 9| 7| 4| 9| 6| 7| 0| 1| 9| 7| 4| 9| 9| 9| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia | 1 2 2 1 1 1 1 1 1|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 |
Hyperplasia | |
Inflammation, Chronic | 3 2 1 1 |
Inflammation, Suppurative | 3 |
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Hyperplasia, Cystic | 1 |
Pigmentation | |
__________________________________________________________________________|
Vagina | + M + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Hemorrhage | 1 |
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Pigmentation | |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 3 2 |
Hyperplasia, Plasma Cell | 2 2 2 |
Pigmentation | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 3 3 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 4| 5| 7| 5| 4| 5| 7| 2| 6| 6| 5| 7| 4| 5| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 8| 5| 2| 2| 2| 8| 5| 9| 2| 2| 3| 8| 9| 2| 5| 5| 2| 2| 2| 5| 9| 2|
| 9| 9| 7| 0| 7| 8| 4| 9| 9| 7| 4| 9| 6| 7| 0| 1| 9| 7| 4| 9| 9| 9| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 3 |
Developmental Malformation | |
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 |
Infiltration Cellular, Histiocyte | |
Necrosis | 3 |
Pigmentation | 3 3 3 3 3 3 3 2 3 2 2 2 2 2 2 3 2|
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + M + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 3 1 1 2 2 2 1 3 2 2 1 2 1 2|
Hyperplasia, Lobular | 3 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Exudate | X |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Osteopetrosis | 2 3 3 3 2 3 2 2 2 2|
Femur, Osteopetrosis | 2 3 2 2 2 |
Sternum, Osteopetrosis | 2 2 3 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X|
Developmental Malformation | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Foreign Body | |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 1 1 |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 4| 5| 7| 5| 4| 5| 7| 2| 6| 6| 5| 7| 4| 5| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 8| 5| 2| 2| 2| 8| 5| 9| 2| 2| 3| 8| 9| 2| 5| 5| 2| 2| 2| 5| 9| 2|
| 9| 9| 7| 0| 7| 8| 4| 9| 9| 7| 4| 9| 6| 7| 0| 1| 9| 7| 4| 9| 9| 9| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X |
Foreign Body | 2 |
Fungus | X X X |
Glands, Hyperplasia | |
Mucosa, Hyperplasia | 3 2 3 2 1 2 |
Mucosa, Metaplasia, Squamous | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2|
Inflammation, Suppurative | |
Mineralization | 3 3 2 3 3 3 2 3 3 2 3 3 2 2 3 3 3 3 3 2 2 3 3 3|
Nephropathy | 1 1 2 2 2 1 2 1 1 1 2 1 1 2 1 2 1 2 1 1 1 2 2|
Interstitial Tissue, Pigmentation | |
Renal Tubule, Cytoplasmic Alteration | 2 2 |
Renal Tubule, Pigmentation | 2 4 3 2 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mucosa, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 6| 7| 4| 7| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 6| 7| 4| 6| 5| 7| 7|
DAY ON TEST | 2| 0| 5| 2| 2| 2| 5| 2| 2| 2| 5| 2| 4| 4| 2| 5| 2| 2| 5| 2| 5| 0| 7| 2| 2|
| 9| 3| 7| 9| 5| 9| 7| 9| 9| 9| 7| 3| 7| 5| 9| 7| 9| 9| 0| 9| 7| 4| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Subacute | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X|
Granuloma | 2 1 3 1 2 1 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X X X X |
Hyperplasia, Focal | 2 3 3 2 3 2|
Hyperplasia, Lymphoid | |
Inflammation, Subacute | 1 1 2 1 2 2 |
Mixed Cell Focus | X X X X X |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 1 2 1 1 2 |
Centrilobular, Atrophy | 3 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 3 4 |
Kupffer Cell, Pigmentation | 1 |
Lobules, Necrosis | 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 1 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 2 1 2 2 1 |
Acinar Cell, Cytoplasmic Alteration | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Acinar Cell, Cytoplasmic Alteration | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 |
Erosion | |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 6| 7| 4| 7| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 6| 7| 4| 6| 5| 7| 7|
DAY ON TEST | 2| 0| 5| 2| 2| 2| 5| 2| 2| 2| 5| 2| 4| 4| 2| 5| 2| 2| 5| 2| 5| 0| 7| 2| 2|
| 9| 3| 7| 9| 5| 9| 7| 9| 9| 9| 7| 3| 7| 5| 9| 7| 9| 9| 0| 9| 7| 4| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 2 3 3 |
Mucosa, Hyperplasia | 3 2 2 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X|
Edema | 2 2 |
Erosion | |
Ulcer | 2 2 |
Epithelium, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 1 2 1 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X|
Angiectasis | 2 2 2 2 |
Atrophy | 4 |
Basophilic Focus | |
Congestion | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal | 1 2 2 |
Hypertrophy, Focal | 2 |
Metaplasia, Osseous | |
Necrosis | |
Pigmentation | 3 3 |
Vacuolization Cytoplasmic, Diffuse | 3 |
Vacuolization Cytoplasmic, Focal | 1 2 2 1 1 2 1 1 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 3 4 |
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Atrophy | 4 |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hyperplasia | 1 1 2 2 2|
Pars Intermedia, Angiectasis | 2 2 |
Pars Intermedia, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 6| 7| 4| 7| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 6| 7| 4| 6| 5| 7| 7|
DAY ON TEST | 2| 0| 5| 2| 2| 2| 5| 2| 2| 2| 5| 2| 4| 4| 2| 5| 2| 2| 5| 2| 5| 0| 7| 2| 2|
| 9| 3| 7| 9| 5| 9| 7| 9| 9| 9| 7| 3| 7| 5| 9| 7| 9| 9| 0| 9| 7| 4| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia | 3 2 2 1 1 1 2 1|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + I + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | 2 1 |
Inflammation, Chronic | 2 2 1 |
Inflammation, Suppurative | 2 2 |
Necrosis | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 |
Hyperplasia, Cystic | |
Pigmentation | |
__________________________________________________________________________|
Vagina | + M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Pigmentation | 3 3 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Pancreatic, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 1 |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 2 2 |
Pigmentation | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 1 |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | 2|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 6| 7| 4| 7| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 6| 7| 4| 6| 5| 7| 7|
DAY ON TEST | 2| 0| 5| 2| 2| 2| 5| 2| 2| 2| 5| 2| 4| 4| 2| 5| 2| 2| 5| 2| 5| 0| 7| 2| 2|
| 9| 3| 7| 9| 5| 9| 7| 9| 9| 9| 7| 3| 7| 5| 9| 7| 9| 9| 0| 9| 7| 4| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | |
Developmental Malformation | |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 2 2 3 2 2 2 2 1 2|
Infiltration Cellular, Histiocyte | 2 |
Necrosis | |
Pigmentation | 3 2 3 2 2 2 2 2 2 2 3 2 2 3 3 2 2 3 3 2 3|
Lymphoid Follicle, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 2 1 2 2 3 2 1 3 2 2 2 2 2 3 1 2 1|
Hyperplasia, Lobular | 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 3 |
Exudate | X |
Inflammation, Subacute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Osteopetrosis | 2 3 3 2 3 3 |
Femur, Osteopetrosis | 4 3 3 3 3 |
Sternum, Osteopetrosis | 4 3 2 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X X|
Developmental Malformation | |
Hydrocephalus | 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | 1 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 2 2 1 1 1 1|
Inflammation, Subacute | 1 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 6| 7| 4| 7| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 6| 7| 4| 6| 5| 7| 7|
DAY ON TEST | 2| 0| 5| 2| 2| 2| 5| 2| 2| 2| 5| 2| 4| 4| 2| 5| 2| 2| 5| 2| 5| 0| 7| 2| 2|
| 9| 3| 7| 9| 5| 9| 7| 9| 9| 9| 7| 3| 7| 5| 9| 7| 9| 9| 0| 9| 7| 4| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Suppurative | 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
Foreign Body | 2 1 |
Fungus | X |
Glands, Hyperplasia | |
Mucosa, Hyperplasia | |
Mucosa, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 3 |
Retina, Atrophy | 3 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Inflammation, Suppurative | 1|
Mineralization | 2 3 3 3 3 3 3 2 2 3 2 2 2 2 2 2 1 3 2 3 3 3 3 3 2|
Nephropathy | 2 1 1 1 2 2 3 2 2 2 2 3 1 1 1 1 2 1 1 3 1 1 1 2 2|
Interstitial Tissue, Pigmentation | 2 |
Renal Tubule, Cytoplasmic Alteration | 3 |
Renal Tubule, Pigmentation | 4 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 5| 2| 4| 7| 2| 2| 2| | |
| 9| 9| 9| 7| 9| 6| 4| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
VEHICLE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Dilatation | | 1 2.0|
Inflammation, Subacute | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Inflammation, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 1 1 | 6 1.7|
Basophilic Focus | X X X X X X X X X X | 45 |
Clear Cell Focus | X | 10 |
Granuloma | 1 | 13 1.6|
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | X | 14 |
Hyperplasia, Focal | | 9 2.8|
Hyperplasia, Lymphoid | | 3 1.3|
Inflammation, Subacute | 1 | 10 1.3|
Mixed Cell Focus | X | 7 |
Bile Duct, Cyst | | 3 |
Bile Duct, Hyperplasia | 1 1 1 | 14 1.4|
Centrilobular, Atrophy | 2 2 | 7 2.1|
Hepatocyte, Vacuolization Cytoplasmic| 2 4 | 10 2.9|
Kupffer Cell, Pigmentation | 1 3 | 3 1.7|
Lobules, Necrosis | 1 | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | + + | 9 |
Accessory Spleen | | 1 |
Fat, Necrosis | 2 | 7 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | 1 | 17 1.5|
Acinar Cell, Cytoplasmic Alteration | | 4 2.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | 1 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 5| 2| 4| 7| 2| 2| 2| | |
| 9| 9| 9| 7| 9| 6| 4| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
VEHICLE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinar Cell, Cytoplasmic Alteration | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 4 2.3|
Erosion | | 1 1.0|
Inflammation, Subacute | | 1 2.0|
Ulcer | | 5 2.8|
Mucosa, Hyperplasia | | 8 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Edema | | 2 2.0|
Erosion | 1 | 5 1.4|
Ulcer | | 2 2.0|
Epithelium, Dilatation | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 | 18 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X | 11 |
Angiectasis | 2 | 7 2.0|
Atrophy | | 2 3.5|
Basophilic Focus | | 1 |
Congestion | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 | 4 1.3|
Hyperplasia, Focal | 1 | 6 1.3|
Hypertrophy, Focal | | 1 2.0|
Metaplasia, Osseous | | 1 2.0|
Necrosis | | 1 3.0|
Pigmentation | | 2 3.0|
Vacuolization Cytoplasmic, Diffuse | | 1 3.0|
Vacuolization Cytoplasmic, Focal | 2 3 | 14 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 4 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + | 57 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 5| 2| 4| 7| 2| 2| 2| | |
| 9| 9| 9| 7| 9| 6| 4| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
VEHICLE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pigmentation | | 2 3.5|
Pars Distalis, Angiectasis | 2 4 2 | 11 2.5|
Pars Distalis, Atrophy | | 1 4.0|
Pars Distalis, Cyst | X X X X | 23 |
Pars Distalis, Hyperplasia | 1 1 1 | 16 1.7|
Pars Intermedia, Angiectasis | 2 | 4 2.0|
Pars Intermedia, Cyst | X X X | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 3 1 1 1 | 21 1.4|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Ectasia | | 1 4.0|
Hyperplasia | 2 2 | 4 1.8|
Inflammation, Chronic | 2 | 8 1.8|
Inflammation, Suppurative | 2 | 4 2.3|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | X | 12 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | 2 | 4 2.0|
Hyperplasia, Cystic | 2 | 2 1.5|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | M | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 14 |
Mediastinal, Hemorrhage | | 2 1.5|
Mediastinal, Hyperplasia, Histiocytic| | 1 3.0|
Mediastinal, Pigmentation | | 2 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 5| 2| 4| 7| 2| 2| 2| | |
| 9| 9| 9| 7| 9| 6| 4| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
VEHICLE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Ectasia | 2 2 | 4 2.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | | 3 2.3|
Hyperplasia, Plasma Cell | 2 | 7 2.0|
Pigmentation | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Ectasia | 2 | 1 2.0|
Hemorrhage | | 3 2.3|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia, Plasma Cell | 2 | 2 2.0|
Inflammation, Suppurative | | 1 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Congestion | | 1 3.0|
Developmental Malformation | X | 1 |
Fibrosis | 2 | 4 2.5|
Hematopoietic Cell Proliferation | 2 2 | 19 2.1|
Infiltration Cellular, Histiocyte | | 1 2.0|
Necrosis | 4 | 2 3.5|
Pigmentation | 2 3 3 2 2 2 | 44 2.4|
Lymphoid Follicle, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Congestion | | 1 3.0|
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | 1 1 2 2 2 2 | 41 1.8|
Hyperplasia, Lobular | | 5 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 3 2.0|
Exudate | | 2 |
Inflammation, Subacute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 5| 2| 4| 7| 2| 2| 2| | |
| 9| 9| 9| 7| 9| 6| 4| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
VEHICLE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Calvarium, Osteopetrosis | 2 2 2 2 | 20 2.4|
Femur, Osteopetrosis | 4 2 | 12 2.8|
Sternum, Osteopetrosis | 4 2 | 12 2.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X | 16 |
Developmental Malformation | X | 1 |
Hydrocephalus | | 3 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Foreign Body | | 1 1.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | | 1 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 24 1.2|
Inflammation, Subacute | | 1 1.0|
Inflammation, Suppurative | | 1 3.0|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | | 4 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 7 |
Foreign Body | | 3 1.7|
Fungus | | 4 |
Glands, Hyperplasia | 2 | 1 2.0|
Mucosa, Hyperplasia | 2 | 7 2.1|
Mucosa, Metaplasia, Squamous | | 4 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Mucosa, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 3.0|
Retina, Atrophy | | 2 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 5| 2| 4| 7| 2| 2| 2| | |
| 9| 9| 9| 7| 9| 6| 4| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
VEHICLE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Infarct | | 1 2.0|
Inflammation, Suppurative | 1 | 2 1.0|
Mineralization | 2 3 3 3 2 2 2 3 3 3 | 59 2.6|
Nephropathy | 3 3 1 1 1 1 1 1 2 2 | 58 1.6|
Interstitial Tissue, Pigmentation | | 1 2.0|
Renal Tubule, Cytoplasmic Alteration | 3 3 | 5 2.6|
Renal Tubule, Pigmentation | 2 | 10 2.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 1.0|
Mucosa, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 4| 5| 7| 6| 5| 7| 4| 7| 7| 6| 5| 7| 4| 7| 5|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 5| 3| 5| 3| 5| 3| 2| 7| 8| 3| 5| 3| 3| 4| 0| 3| 5| 3| 5|
| 4| 1| 1| 1| 1| 1| 7| 1| 2| 1| 7| 3| 7| 4| 9| 1| 7| 1| 1| 6| 2| 1| 7| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3|
Edema | 3|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | X |
Congestion | |
Granuloma | 1 1 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X X X|
Hyperplasia, Focal | 3 3 3 3 3|
Hyperplasia, Lymphoid | 1 |
Inflammation, Subacute | 1 2 1 1 2 1 1 1 |
Mixed Cell Focus | X X X |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 2 |
Centrilobular, Atrophy | 2 2 2 2 4|
Centrilobular, Necrosis | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 1 2 2 2 3|
Kupffer Cell, Pigmentation | 2 1 1 |
Lobules, Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | + + +|
Fat, Necrosis | 3 4 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 1 1 3 1 1 2 2 1 1|
Cyst | X |
Acinar Cell, Cytoplasmic Alteration | |
Acinar Cell, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Acinar Cell, Cytoplasmic Alteration | 3 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 3|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 4| 5| 7| 6| 5| 7| 4| 7| 7| 6| 5| 7| 4| 7| 5|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 5| 3| 5| 3| 5| 3| 2| 7| 8| 3| 5| 3| 3| 4| 0| 3| 5| 3| 5|
| 4| 1| 1| 1| 1| 1| 7| 1| 2| 1| 7| 3| 7| 4| 9| 1| 7| 1| 1| 6| 2| 1| 7| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1|
Ulcer | 3 |
Mucosa, Hyperplasia | 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 2 2|
Ulcer | |
Epithelium, Dilatation | 2 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 1 |
Thrombosis | X|
Myocardium, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X |
Angiectasis | 2 2 2 |
Congestion | |
Cyst | |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 2 |
Hyperplasia, Focal | 1 2 1 1 1 1 2 |
Hypertrophy, Focal | 2 |
Pigmentation | 3 |
Vacuolization Cytoplasmic, Diffuse | 2 2|
Vacuolization Cytoplasmic, Focal | 2 1 3 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 3 |
Pars Distalis, Angiectasis | 2 3 2 3 2 2 3 |
Pars Distalis, Cyst | X X X X X X X X|
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 4| 5| 7| 6| 5| 7| 4| 7| 7| 6| 5| 7| 4| 7| 5|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 5| 3| 5| 3| 5| 3| 2| 7| 8| 3| 5| 3| 3| 4| 0| 3| 5| 3| 5|
| 4| 1| 1| 1| 1| 1| 7| 1| 2| 1| 7| 3| 7| 4| 9| 1| 7| 1| 1| 6| 2| 1| 7| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia | 1 1 1 1 1 1 2 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia | 2 2 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X|
Mineralization | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrometra | 2 |
Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Vagina | + + M |
Exudate | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
Myelofibrosis | 3 1 3 1 4|
__________________________________________________________________________|
Lymph Node | + + + + + +|
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | 3 |
Pancreatic, Hemorrhage | |
Renal, Hemorrhage | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 2 |
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hemorrhage | 3|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 4| 5| 7| 6| 5| 7| 4| 7| 7| 6| 5| 7| 4| 7| 5|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 5| 3| 5| 3| 5| 3| 2| 7| 8| 3| 5| 3| 3| 4| 0| 3| 5| 3| 5|
| 4| 1| 1| 1| 1| 1| 7| 1| 2| 1| 7| 3| 7| 4| 9| 1| 7| 1| 1| 6| 2| 1| 7| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Developmental Malformation | X |
Fibrosis | 4 2 1 3|
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 1 2 2|
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 4 1 2 1 2 2 1 3 1 1 2 1 3 2 1 3|
Hyperplasia, Lobular | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrous Osteodystrophy | 1 |
Calvarium, Osteopetrosis | 1 2 2 2 |
Femur, Osteopetrosis | 3 2 2 3 |
Sternum, Osteopetrosis | 3 1 2 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Developmental Malformation | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Edema | 2 2 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 3 1 2 2 3 1 2 3 1 1 |
Inflammation, Subacute | 1 2 |
Alveolar Epithelium, Hyperplasia | 1 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X|
Foreign Body | 2 |
Fungus | |
Glands, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 4| 5| 7| 6| 5| 7| 4| 7| 7| 6| 5| 7| 4| 7| 5|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 5| 3| 5| 3| 5| 3| 2| 7| 8| 3| 5| 3| 3| 4| 0| 3| 5| 3| 5|
| 4| 1| 1| 1| 1| 1| 7| 1| 2| 1| 7| 3| 7| 4| 9| 1| 7| 1| 1| 6| 2| 1| 7| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Hyperplasia | 2|
Mucosa, Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 1|
Mineralization | 2 3 3 3 2 3 3 2 3 3 3 3 2 3 3 3 3 3 3 2 3 3 3 2 3|
Nephropathy | 1 2 3 4 1 3 1 2 1 3 2 1 1 2 2 2 2 2 2 2 2 2 1 2 2|
Interstitial Tissue, Pigmentation | |
Renal Tubule, Cytoplasmic Alteration | 2 |
Renal Tubule, Pigmentation | 3 2 4 2 3 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 7| 6| 7| 7| 4| 6| 7| 5| 4| 6| 7| 7| 6| 6| 4| 7| 5| 6| 6| 4| 5|
DAY ON TEST | 3| 2| 2| 0| 3| 4| 3| 3| 5| 2| 3| 9| 5| 2| 3| 3| 1| 1| 5| 3| 4| 1| 1| 5| 9|
| 2| 4| 3| 3| 1| 5| 1| 1| 7| 4| 1| 1| 7| 5| 1| 1| 1| 0| 7| 1| 2| 8| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + I + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Edema | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Congestion | 3 |
Granuloma | 2 2 1 1 1 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 3 3 3 |
Hyperplasia, Lymphoid | |
Inflammation, Subacute | 1 1 1 1 1 1|
Mixed Cell Focus | X X X X X |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 1 3 2 1 1 2 1 1|
Centrilobular, Atrophy | 2 2 2 2 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 3 3 |
Kupffer Cell, Pigmentation | 3 1 2 2 1 |
Lobules, Necrosis | 1 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 1 1 1 1 2 1 1 2 3 |
Cyst | |
Acinar Cell, Cytoplasmic Alteration | 3 |
Acinar Cell, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Acinar Cell, Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 7| 6| 7| 7| 4| 6| 7| 5| 4| 6| 7| 7| 6| 6| 4| 7| 5| 6| 6| 4| 5|
DAY ON TEST | 3| 2| 2| 0| 3| 4| 3| 3| 5| 2| 3| 9| 5| 2| 3| 3| 1| 1| 5| 3| 4| 1| 1| 5| 9|
| 2| 4| 3| 3| 1| 5| 1| 1| 7| 4| 1| 1| 7| 5| 1| 1| 1| 0| 7| 1| 2| 8| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 3 |
Ulcer | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 2 2 |
Ulcer | 2 |
Epithelium, Dilatation | 2 2 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 2 1 |
Thrombosis | |
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X |
Angiectasis | 2 |
Congestion | 2 2 |
Cyst | X |
Hematopoietic Cell Proliferation | 1 1 |
Hemorrhage | 2 |
Hyperplasia, Focal | 1 2 1 |
Hypertrophy, Focal | 2 |
Pigmentation | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 2 2 2 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 3 |
Pars Distalis, Angiectasis | 2 1 3 |
Pars Distalis, Cyst | X X X X X X X X X X |
Pars Distalis, Hyperplasia | 1 1 2 1 3 2 2 2 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 7| 6| 7| 7| 4| 6| 7| 5| 4| 6| 7| 7| 6| 6| 4| 7| 5| 6| 6| 4| 5|
DAY ON TEST | 3| 2| 2| 0| 3| 4| 3| 3| 5| 2| 3| 9| 5| 2| 3| 3| 1| 1| 5| 3| 4| 1| 1| 5| 9|
| 2| 4| 3| 3| 1| 5| 1| 1| 7| 4| 1| 1| 7| 5| 1| 1| 1| 0| 7| 1| 2| 8| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia | 2 1 1 1 1 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia | |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Mineralization | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hydrometra | 3 2 |
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Vagina | + M |
Exudate | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 2 |
Myelofibrosis | 3 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Pigmentation | 3 3 |
Pancreatic, Hemorrhage | 2 |
Renal, Hemorrhage | 3 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | 2 3 2 |
Infiltration Cellular, Mast Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 3 |
Hyperplasia, Lymphoid | 2 2 2 |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Mast Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 7| 6| 7| 7| 4| 6| 7| 5| 4| 6| 7| 7| 6| 6| 4| 7| 5| 6| 6| 4| 5|
DAY ON TEST | 3| 2| 2| 0| 3| 4| 3| 3| 5| 2| 3| 9| 5| 2| 3| 3| 1| 1| 5| 3| 4| 1| 1| 5| 9|
| 2| 4| 3| 3| 1| 5| 1| 1| 7| 4| 1| 1| 7| 5| 1| 1| 1| 0| 7| 1| 2| 8| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Developmental Malformation | |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 1 2 1 2 3 3 |
Pigmentation | 3 2 2 2 2 2 3 2 3 3 2 2 2 2 2 3 3 3|
Lymphoid Follicle, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + M + + + + + + M|
Congestion | |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 3 2 2 2 1 2 2 2 2 2 1 2 2 2 1 1|
Hyperplasia, Lobular | 1 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrous Osteodystrophy | |
Calvarium, Osteopetrosis | 2 2 3 |
Femur, Osteopetrosis | 3 |
Sternum, Osteopetrosis | 2 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X|
Developmental Malformation | X |
Hydrocephalus | 3 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2|
Edema | 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 3 |
Inflammation, Subacute | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X |
Foreign Body | 2 2 |
Fungus | X X |
Glands, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 7| 6| 7| 7| 4| 6| 7| 5| 4| 6| 7| 7| 6| 6| 4| 7| 5| 6| 6| 4| 5|
DAY ON TEST | 3| 2| 2| 0| 3| 4| 3| 3| 5| 2| 3| 9| 5| 2| 3| 3| 1| 1| 5| 3| 4| 1| 1| 5| 9|
| 2| 4| 3| 3| 1| 5| 1| 1| 7| 4| 1| 1| 7| 5| 1| 1| 1| 0| 7| 1| 2| 8| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Hyperplasia | 2 2 2 |
Mucosa, Metaplasia, Squamous | 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 3 |
Retina, Atrophy | 3 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mineralization | 3 3 2 2 2 3 3 2 3 3 3 3 2 2 3 3 3 2 3 2 3 3 2 3 3|
Nephropathy | 2 1 3 1 2 1 2 2 3 1 2 2 2 2 2 1 1 2 1 3 1 1|
Interstitial Tissue, Pigmentation | 3 |
Renal Tubule, Cytoplasmic Alteration | 3 3 2 |
Renal Tubule, Pigmentation | 3 2 3 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 4| 7| 7| 4| | |
DAY ON TEST | 5| 9| 3| 0| 3| 3| 3| 3| 3| 5| | |
| 7| 0| 1| 3| 1| 1| 0| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Edema | | 1 2.0|
Parasite Metazoan | X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Dilatation | | 1 3.0|
Edema | | 1 3.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 1 | 5 2.4|
Basophilic Focus | X X X X X X X X | 39 |
Clear Cell Focus | X X X X | 5 |
Congestion | | 1 3.0|
Granuloma | 3 2 1 1 | 13 1.5|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X X X | 16 |
Hyperplasia, Focal | 3 3 2 | 11 2.9|
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Subacute | 2 1 | 16 1.2|
Mixed Cell Focus | X | 9 |
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | 1 1 | 22 1.3|
Centrilobular, Atrophy | | 9 2.2|
Centrilobular, Necrosis | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 13 2.2|
Kupffer Cell, Pigmentation | 3 | 9 1.8|
Lobules, Necrosis | | 4 1.3|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Necrosis | 3 3 | 6 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | 2 2 3 2 | 29 1.5|
Cyst | | 1 |
Acinar Cell, Cytoplasmic Alteration | | 1 3.0|
Acinar Cell, Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 4| 7| 7| 4| | |
DAY ON TEST | 5| 9| 3| 0| 3| 3| 3| 3| 3| 5| | |
| 7| 0| 1| 3| 1| 1| 0| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | | 2 1.0|
Acinar Cell, Cytoplasmic Alteration | 3 | 4 2.8|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | 3 1 | 5 2.6|
Erosion | 2 | 3 2.0|
Ulcer | 3 3 | 3 3.0|
Mucosa, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | 2 | 3 2.0|
Erosion | | 4 2.0|
Ulcer | | 1 2.0|
Epithelium, Dilatation | | 3 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 1 2 | 15 1.3|
Thrombosis | | 1 |
Myocardium, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X | 11 |
Angiectasis | | 4 2.0|
Congestion | | 2 2.0|
Cyst | | 1 |
Hematopoietic Cell Proliferation | | 3 1.0|
Hemorrhage | | 2 2.0|
Hyperplasia, Focal | 1 2 2 2 | 14 1.4|
Hypertrophy, Focal | | 2 2.0|
Pigmentation | 2 | 2 2.5|
Vacuolization Cytoplasmic, Diffuse | | 2 2.0|
Vacuolization Cytoplasmic, Focal | 1 2 | 12 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 10 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 4| 7| 7| 4| | |
DAY ON TEST | 5| 9| 3| 0| 3| 3| 3| 3| 3| 5| | |
| 7| 0| 1| 3| 1| 1| 0| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pigmentation | | 2 3.0|
Pars Distalis, Angiectasis | | 10 2.3|
Pars Distalis, Cyst | X | 19 |
Pars Distalis, Hyperplasia | | 11 1.8|
Pars Intermedia, Angiectasis | 2 | 2 2.0|
Pars Intermedia, Cyst | | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | X | 3 |
C-Cell, Hyperplasia | 1 1 1 | 17 1.1|
Follicle, Cyst | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Ectasia | | 2 2.0|
Hyperplasia | 2 | 4 2.0|
Inflammation, Chronic | 2 | 3 1.7|
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | X X X X | 14 |
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hemorrhage | | 1 3.0|
Hydrometra | | 3 2.3|
Hyperplasia, Cystic | | 2 1.5|
__________________________________________________________________________|____________|
Vagina | | 3 |
Exudate | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 2 2.5|
Myelofibrosis | 2 4 1 | 11 2.3|
__________________________________________________________________________|____________|
Lymph Node | + | 15 |
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Pigmentation | | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 4| 7| 7| 4| | |
DAY ON TEST | 5| 9| 3| 0| 3| 3| 3| 3| 3| 5| | |
| 7| 0| 1| 3| 1| 1| 0| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Hemorrhage | | 1 2.0|
Renal, Hemorrhage | | 1 3.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Ectasia | | 5 2.2|
Hemorrhage | | 2 3.0|
Hyperplasia, Lymphoid | | 3 2.3|
Hyperplasia, Plasma Cell | 4 2 2 | 8 2.5|
Infiltration Cellular, Mast Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Hemorrhage | | 3 3.0|
Hyperplasia, Lymphoid | 2 2 | 5 2.0|
Hyperplasia, Plasma Cell | 2 | 1 2.0|
Infiltration Cellular, Mast Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 |
Fibrosis | | 5 2.6|
Hematopoietic Cell Proliferation | 2 2 2 | 19 2.1|
Pigmentation | 2 2 2 2 2 2 2 2 | 42 2.2|
Lymphoid Follicle, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
Congestion | | 1 3.0|
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Hyperplasia, Cystic | 2 1 2 2 1 2 3 1 2 1 | 47 1.8|
Hyperplasia, Lobular | 2 4 | 7 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 |
Fibrous Osteodystrophy | | 1 1.0|
Calvarium, Osteopetrosis | 3 3 | 9 2.2|
Femur, Osteopetrosis | 3 3 | 7 2.7|
Sternum, Osteopetrosis | 3 3 | 8 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 4| 7| 7| 4| | |
DAY ON TEST | 5| 9| 3| 0| 3| 3| 3| 3| 3| 5| | |
| 7| 0| 1| 3| 1| 1| 0| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X X | 13 |
Developmental Malformation | | 1 |
Hydrocephalus | 2 2 | 6 2.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 4 2.3|
Edema | | 3 2.0|
Hemorrhage | | 2 1.5|
Infiltration Cellular, Histiocyte | 1 | 19 1.6|
Inflammation, Subacute | | 3 1.3|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X | 11 |
Foreign Body | | 3 2.0|
Fungus | | 2 |
Glands, Hyperplasia | | 1 2.0|
Mucosa, Hyperplasia | | 4 2.0|
Mucosa, Metaplasia, Squamous | | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 5 |
Cataract | 2 | 4 2.8|
Retina, Atrophy | 3 | 4 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 3 1.3|
Mineralization | 3 3 3 3 2 2 2 2 2 3 | 60 2.7|
Nephropathy | 1 2 2 2 2 2 1 1 2 1 | 57 1.8|
Interstitial Tissue, Pigmentation | | 1 3.0|
Renal Tubule, Cytoplasmic Alteration | | 4 2.5|
Renal Tubule, Pigmentation | 4 | 12 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 4| 7| 7| 4| | |
DAY ON TEST | 5| 9| 3| 0| 3| 3| 3| 3| 3| 5| | |
| 7| 0| 1| 3| 1| 1| 0| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Mucosa, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 5| 6| 5| 4| 5| 7| 7| 4| 7| 6| 3| 7| 6| 4| 4| 7| 7| 3| 5| 4| 7|
DAY ON TEST | 3| 6| 9| 3| 7| 3| 6| 5| 7| 3| 0| 5| 3| 5| 7| 3| 9| 6| 5| 2| 3| 3| 3| 5| 3|
| 0| 2| 9| 0| 5| 7| 5| 7| 3| 0| 3| 7| 0| 1| 7| 0| 4| 8| 7| 4| 0| 2| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.50% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 |
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | X X|
Eosinophilic Focus | |
Granuloma | 1 1 2 1 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X X X X X X X |
Hyperplasia, Focal | 3 3 2 1 2 3|
Inflammation, Subacute | 1 1 1 |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 |
Centrilobular, Atrophy | 2 3 |
Centrilobular, Necrosis | 2 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 4 4 2 2 |
Kupffer Cell, Hyperplasia | 2 |
Kupffer Cell, Pigmentation | 2 3 |
Lobules, Necrosis | 3 1|
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 2 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 1 1 2 1 2 |
Hyperplasia, Lymphoid | 1 |
Acinar Cell, Cytoplasmic Alteration | 4 2 3 3 |
Acinar Cell, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Suppurative | 2 |
Acinar Cell, Cytoplasmic Alteration | 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 5| 6| 5| 4| 5| 7| 7| 4| 7| 6| 3| 7| 6| 4| 4| 7| 7| 3| 5| 4| 7|
DAY ON TEST | 3| 6| 9| 3| 7| 3| 6| 5| 7| 3| 0| 5| 3| 5| 7| 3| 9| 6| 5| 2| 3| 3| 3| 5| 3|
| 0| 2| 9| 0| 5| 7| 5| 7| 3| 0| 3| 7| 0| 1| 7| 0| 4| 8| 7| 4| 0| 2| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.50% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 1 |
Fibrosis | 3 4 |
Perforation | X |
Ulcer | 4 3 4 4 2 4 |
Mucosa, Hyperplasia | 4 2 2 3 4 2 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 |
Ulcer | 2 2 |
Epithelium, Dilatation | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Fibrosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 1 1 2 1 1|
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Angiectasis | 3 2 2 2|
Congestion | |
Hematopoietic Cell Proliferation | 2 1 |
Hyperplasia, Focal | 1 2 3|
Hypertrophy, Focal | |
Necrosis | 2 |
Pigmentation | 3 |
Vacuolization Cytoplasmic, Diffuse | 3 2 |
Vacuolization Cytoplasmic, Focal | 1 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +|
Hypertrophy, Focal | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 5| 6| 5| 4| 5| 7| 7| 4| 7| 6| 3| 7| 6| 4| 4| 7| 7| 3| 5| 4| 7|
DAY ON TEST | 3| 6| 9| 3| 7| 3| 6| 5| 7| 3| 0| 5| 3| 5| 7| 3| 9| 6| 5| 2| 3| 3| 3| 5| 3|
| 0| 2| 9| 0| 5| 7| 5| 7| 3| 0| 3| 7| 0| 1| 7| 0| 4| 8| 7| 4| 0| 2| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.50% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pigmentation | 3 2 |
Pars Distalis, Angiectasis | 3 3 3 3 |
Pars Distalis, Cyst | X X X X X X X|
Pars Distalis, Hyperplasia | 2 3 1 3 3 1 1 2 2 |
Pars Intermedia, Angiectasis | 3 |
Pars Intermedia, Cyst | X |
Pars Intermedia, Hyperplasia | 2 |
Pars Intermedia, Hypertrophy, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 1 1 1 1 2|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | 1 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Hyperplasia, Cystic | 1 1 |
Inflammation, Suppurative | |
Pigmentation | |
Prolapse | X |
Endometrium, Fibrosis | 3 |
__________________________________________________________________________|
Vagina | + + M M + |
Exudate | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hypercellularity | 3 2 |
Myelofibrosis | 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Mediastinal, Hemorrhage | 2 2 2 |
Mediastinal, Pigmentation | 2 2 3 |
Pancreatic, Hemorrhage | 1 2 |
Pancreatic, Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 5| 6| 5| 4| 5| 7| 7| 4| 7| 6| 3| 7| 6| 4| 4| 7| 7| 3| 5| 4| 7|
DAY ON TEST | 3| 6| 9| 3| 7| 3| 6| 5| 7| 3| 0| 5| 3| 5| 7| 3| 9| 6| 5| 2| 3| 3| 3| 5| 3|
| 0| 2| 9| 0| 5| 7| 5| 7| 3| 0| 3| 7| 0| 1| 7| 0| 4| 8| 7| 4| 0| 2| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.50% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 2 2 1|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 2 2 2 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 2 4 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
Infiltration Cellular, Mast Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 3 1 |
Hematopoietic Cell Proliferation | 2 2 3 2 4 3 1 2 |
Pigmentation | 2 3 2 3 3 3 2 2 2 2 2 3 2 3 2 2 3 2|
Lymphoid Follicle, Atrophy | 3 |
Red Pulp, Atrophy | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 2 2 2 2 2 1 3 2 2 1 2 1 3 3 2 2 1 1|
Hyperplasia, Lobular | 2 1 |
__________________________________________________________________________|
Skin | + + I + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 |
Calvarium, Osteopetrosis | 3 2 2 2 2 2 2 1 |
Femur, Osteopetrosis | 3 2 2 |
Sternum, Osteopetrosis | 4 2 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hydrocephalus | |
Mineralization | |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 5| 6| 5| 4| 5| 7| 7| 4| 7| 6| 3| 7| 6| 4| 4| 7| 7| 3| 5| 4| 7|
DAY ON TEST | 3| 6| 9| 3| 7| 3| 6| 5| 7| 3| 0| 5| 3| 5| 7| 3| 9| 6| 5| 2| 3| 3| 3| 5| 3|
| 0| 2| 9| 0| 5| 7| 5| 7| 3| 0| 3| 7| 0| 1| 7| 0| 4| 8| 7| 4| 0| 2| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.50% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 3 1 1 1 1 |
Inflammation, Subacute | 2 |
Leukocytosis | 2 |
Alveolar Epithelium, Hyperplasia | 1 3 |
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X|
Foreign Body | 2 3 1 2|
Fungus | X X X |
Mucosa, Hyperplasia | 2 3 2 3 |
Mucosa, Metaplasia, Squamous | 1 2 |
Mucosa, Necrosis | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + +|
Cataract | 3 3 4|
Retina, Atrophy | 4 3 4|
__________________________________________________________________________|
Lacrimal Gland | |
Ectopic Harderian | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 1 1 1 |
Mineralization | 3 2 3 3 2 2 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Nephropathy | 3 4 2 2 2 3 3 2 2 1 3 2 1 2 1 2 4 2 1 1 3 1 1 2 2|
Renal Tubule, Cytoplasmic Alteration | 2 |
Renal Tubule, Pigmentation | 2 3 2 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 4 |
Hemorrhage | 1 3 |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 4| 2| 7| 7| 4| 3| 7| 6| 7| 6|
DAY ON TEST | 5| 0| 5| 3| 8| 0| 3| 3| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 5| 2| 0| 6| 3| 3|
| 2| 1| 7| 0| 4| 8| 0| 0| 7| 0| 0| 7| 0| 3| 8| 9| 5| 0| 0| 7| 1| 3| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Dilatation | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + I + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Mucosa, Hyperplasia, Diffuse | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Eosinophilic Focus | X |
Granuloma | 1 2 1 1 1 2 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X X X X X |
Hyperplasia, Focal | 3 2 1 3 2 1 2 |
Inflammation, Subacute | 1 |
Mixed Cell Focus | X X X X X |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 3|
Centrilobular, Atrophy | 3 2 2|
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 4 2|
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation | 1 3 3 |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 3 1 1 1 1 2 1 1|
Hyperplasia, Lymphoid | |
Acinar Cell, Cytoplasmic Alteration | 3 3 2 |
Acinar Cell, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Suppurative | |
Acinar Cell, Cytoplasmic Alteration | 3 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 4| 2| 7| 7| 4| 3| 7| 6| 7| 6|
DAY ON TEST | 5| 0| 5| 3| 8| 0| 3| 3| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 5| 2| 0| 6| 3| 3|
| 2| 1| 7| 0| 4| 8| 0| 0| 7| 0| 0| 7| 0| 3| 8| 9| 5| 0| 0| 7| 1| 3| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 2 3 2 4 |
Erosion | |
Fibrosis | 3 2 |
Perforation | X |
Ulcer | 4 3 |
Mucosa, Hyperplasia | 4 1 3 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 1 2 |
Erosion | 1|
Ulcer | 2 |
Epithelium, Dilatation | 2|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Fibrosis | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 1 2 1 1 1 |
Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Angiectasis | 2 2 2 |
Congestion | 2 |
Hematopoietic Cell Proliferation | 1 2 |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2|
Necrosis | |
Pigmentation | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 1 3 2 1 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 2 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + M + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 4| 2| 7| 7| 4| 3| 7| 6| 7| 6|
DAY ON TEST | 5| 0| 5| 3| 8| 0| 3| 3| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 5| 2| 0| 6| 3| 3|
| 2| 1| 7| 0| 4| 8| 0| 0| 7| 0| 0| 7| 0| 3| 8| 9| 5| 0| 0| 7| 1| 3| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pigmentation | 2 |
Pars Distalis, Angiectasis | 2 3 2 3|
Pars Distalis, Cyst | X X X X X X X X X X X X X|
Pars Distalis, Hyperplasia | 2 1 1 2 1 1 2 2 2 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | |
Pars Intermedia, Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Hyperplasia, Cystic | 1 1 |
Inflammation, Suppurative | |
Pigmentation | 2 |
Prolapse | |
Endometrium, Fibrosis | |
__________________________________________________________________________|
Vagina | M + + +|
Exudate | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hypercellularity | 4 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Hemorrhage | 1 3 |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage | 1 |
Pancreatic, Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 4| 2| 7| 7| 4| 3| 7| 6| 7| 6|
DAY ON TEST | 5| 0| 5| 3| 8| 0| 3| 3| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 5| 2| 0| 6| 3| 3|
| 2| 1| 7| 0| 4| 8| 0| 0| 7| 0| 0| 7| 0| 3| 8| 9| 5| 0| 0| 7| 1| 3| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 2 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 2 |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 1 1 1 1 2 |
Pigmentation | 2 2 2 2 3 2 3 2 2 2 2 2 3 3 3 2 2|
Lymphoid Follicle, Atrophy | |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Hemorrhage | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 1 2 3 1 2 1 1 3 2 1 1 2 2|
Hyperplasia, Lobular | 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 |
Calvarium, Osteopetrosis | 3 2 |
Femur, Osteopetrosis | 2 |
Sternum, Osteopetrosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hydrocephalus | 3 |
Mineralization | 1 |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 4| 2| 7| 7| 4| 3| 7| 6| 7| 6|
DAY ON TEST | 5| 0| 5| 3| 8| 0| 3| 3| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 5| 2| 0| 6| 3| 3|
| 2| 1| 7| 0| 4| 8| 0| 0| 7| 0| 0| 7| 0| 3| 8| 9| 5| 0| 0| 7| 1| 3| 7| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.50% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 3 2 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 3 3 |
Inflammation, Subacute | 2 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | 1 |
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X |
Foreign Body | 3 |
Fungus | X |
Mucosa, Hyperplasia | 2 3 3 |
Mucosa, Metaplasia, Squamous | 1 |
Mucosa, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 3 |
Retina, Atrophy | 4 3 |
__________________________________________________________________________|
Lacrimal Gland | |
Ectopic Harderian | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 |
Mineralization | 2 3 3 2 3 2 3 3 3 3 2 3 3 2 3 3 3 1 3 3 3 3 3 3 3|
Nephropathy | 4 3 3 1 1 4 3 3 2 2 3 2 2 1 1 2 3 3 2 1 3 3 2|
Renal Tubule, Cytoplasmic Alteration | 1 1 |
Renal Tubule, Pigmentation | 2 2 4|
Transitional Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 6| 7| | |
DAY ON TEST | 5| 3| 3| 4| 5| 3| 3| 3| 9| 3| | |
| 7| 1| 1| 5| 7| 0| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.50% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Ulcer | | 1 4.0|
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + I + + + | 59 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Dilatation | | 1 3.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
Erosion | | 3 2.3|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Mucosa, Hyperplasia, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 3 | 6 2.2|
Basophilic Focus | X X X X X X X | 36 |
Clear Cell Focus | | 4 |
Eosinophilic Focus | X | 2 |
Granuloma | 1 1 | 13 1.2|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 19 |
Hyperplasia, Focal | 3 | 14 2.2|
Inflammation, Subacute | | 4 1.0|
Mixed Cell Focus | | 6 |
Bile Duct, Hyperplasia | 1 1 2 | 16 1.3|
Centrilobular, Atrophy | 2 2 | 7 2.3|
Centrilobular, Necrosis | | 2 2.5|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 | 12 2.8|
Kupffer Cell, Hyperplasia | | 1 2.0|
Kupffer Cell, Pigmentation | | 5 2.4|
Lobules, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 8 |
Fat, Necrosis | | 6 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy | 2 2 1 1 2 | 23 1.5|
Hyperplasia, Lymphoid | | 1 1.0|
Acinar Cell, Cytoplasmic Alteration | 4 | 8 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 6| 7| | |
DAY ON TEST | 5| 3| 3| 4| 5| 3| 3| 3| 9| 3| | |
| 7| 1| 1| 5| 7| 0| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.50% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinar Cell, Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
Acinar Cell, Cytoplasmic Alteration | | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | 3 | 8 2.8|
Erosion | | 1 1.0|
Fibrosis | | 4 3.0|
Perforation | X | 3 |
Ulcer | 4 | 9 3.6|
Mucosa, Hyperplasia | 3 3 | 16 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | 2 | 4 1.8|
Erosion | | 2 1.5|
Ulcer | 3 | 4 2.3|
Epithelium, Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Fibrosis | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 1 1 2 | 23 1.3|
Thrombosis | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X | 7 |
Angiectasis | 2 | 8 2.1|
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | | 4 1.5|
Hyperplasia, Focal | 2 1 1 2 | 8 1.8|
Hypertrophy, Focal | | 1 2.0|
Necrosis | | 1 2.0|
Pigmentation | | 1 3.0|
Vacuolization Cytoplasmic, Diffuse | | 2 2.5|
Vacuolization Cytoplasmic, Focal | 2 1 3 3 | 15 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 6| 7| | |
DAY ON TEST | 5| 3| 3| 4| 5| 3| 3| 3| 9| 3| | |
| 7| 1| 1| 5| 7| 0| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.50% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.0|
Hyperplasia | 1 3 | 9 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 57 |
Fibrosis | 3 | 1 3.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Hypertrophy, Focal | | 1 2.0|
Pigmentation | | 3 2.3|
Pars Distalis, Angiectasis | 3 1 2 | 11 2.5|
Pars Distalis, Cyst | X X X | 23 |
Pars Distalis, Hyperplasia | 1 1 1 | 21 1.7|
Pars Intermedia, Angiectasis | | 1 3.0|
Pars Intermedia, Cyst | X | 2 |
Pars Intermedia, Hyperplasia | | 1 2.0|
Pars Intermedia, Hypertrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | | 1 2.0|
Ultimobranchial Cyst | X | 2 |
C-Cell, Hyperplasia | 1 1 1 | 13 1.2|
Follicle, Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Ectasia | 2 | 1 2.0|
Hyperplasia | 1 2 1 | 4 1.3|
Inflammation, Chronic | 1 | 3 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | X X X X X | 17 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | | 2 2.0|
Hyperplasia, Cystic | 2 | 5 1.2|
Inflammation, Suppurative | 1 | 1 1.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 6| 7| | |
DAY ON TEST | 5| 3| 3| 4| 5| 3| 3| 3| 9| 3| | |
| 7| 1| 1| 5| 7| 0| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.50% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Prolapse | | 1 |
Endometrium, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | M M | 6 |
Exudate | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Hypercellularity | | 3 3.0|
Myelofibrosis | | 3 1.3|
__________________________________________________________________________|____________|
Lymph Node | + | 12 |
Mediastinal, Hemorrhage | | 5 2.0|
Mediastinal, Pigmentation | | 3 2.3|
Pancreatic, Hemorrhage | | 3 1.3|
Pancreatic, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Ectasia | 2 2 2 | 8 2.0|
Hemorrhage | | 3 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 2 2 | 10 2.1|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hemorrhage | 1 | 8 1.8|
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Infiltration Cellular, Mast Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Developmental Malformation | X | 1 |
Fibrosis | 1 | 3 1.7|
Hematopoietic Cell Proliferation | 1 2 2 | 17 1.9|
Pigmentation | 2 2 2 2 2 3 2 | 42 2.3|
Lymphoid Follicle, Atrophy | | 1 3.0|
Red Pulp, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + | 59 |
Congestion | | 2 3.0|
Hemorrhage | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 6| 7| | |
DAY ON TEST | 5| 3| 3| 4| 5| 3| 3| 3| 9| 3| | |
| 7| 1| 1| 5| 7| 0| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.50% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | 1 1 1 1 1 2 2 1 3 | 45 1.7|
Hyperplasia, Lobular | | 5 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | | 4 1.5|
Calvarium, Osteopetrosis | 2 | 11 2.1|
Femur, Osteopetrosis | | 4 2.3|
Sternum, Osteopetrosis | | 4 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X X | 12 |
Hydrocephalus | | 1 3.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 4 2.5|
Hemorrhage | 1 | 2 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 22 1.3|
Inflammation, Subacute | | 2 2.0|
Leukocytosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 4 1.5|
Bronchiole, Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X X X | 15 |
Foreign Body | | 5 2.2|
Fungus | X | 5 |
Mucosa, Hyperplasia | 3 | 8 2.6|
Mucosa, Metaplasia, Squamous | 2 | 4 1.5|
Mucosa, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 6| 7| | |
DAY ON TEST | 5| 3| 3| 4| 5| 3| 3| 3| 9| 3| | |
| 7| 1| 1| 5| 7| 0| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.50% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Cataract | | 5 3.2|
Retina, Atrophy | | 5 3.6|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
Ectopic Harderian | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hemorrhage | | 1 1.0|
Inflammation, Suppurative | 1 1 1 | 13 1.0|
Mineralization | 2 3 3 3 3 3 3 2 2 2 | 60 2.8|
Nephropathy | 2 3 3 3 2 2 2 2 3 3 | 58 2.3|
Renal Tubule, Cytoplasmic Alteration | | 3 1.3|
Renal Tubule, Pigmentation | | 6 2.5|
Transitional Epithelium, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 2 3.0|
Hemorrhage | | 2 2.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 6| 5| 5| 4| 5| 6| 4| 5| 4| 4| 2| 7| 6| 6| 7| 6| 7| 6| 7|
DAY ON TEST | 5| 3| 3| 1| 5| 3| 1| 1| 7| 5| 9| 2| 5| 9| 7| 5| 0| 3| 2| 1| 3| 6| 3| 7| 3|
| 7| 0| 0| 0| 7| 0| 0| 1| 6| 7| 1| 5| 7| 7| 6| 7| 6| 0| 5| 7| 0| 7| 0| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.00% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Eosinophilic Focus | |
Granuloma | 1 1 1 1 1 3 1 1 3 |
Hematopoietic Cell Proliferation | 2 1 |
Hepatodiaphragmatic Nodule | X X X X X X X |
Hyperplasia, Focal | 2 3 |
Hyperplasia, Lymphoid | |
Inflammation, Subacute | 1 1 2 |
Mixed Cell Focus | X |
Thrombosis | |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 2 1 1 1 1 2 1 1|
Centrilobular, Atrophy | 3 2 2 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 2 |
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation | 2 2 |
Lobules, Necrosis | 1 2 1 |
__________________________________________________________________________|
Mesentery | +|
Accessory Spleen | |
Fat, Necrosis | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 2 2 3 1 2 2 1 1 2 2 1|
Cyst | X |
Ectopic Liver | |
Acinar Cell, Cytoplasmic Alteration | 3 2 3 3 3 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 6| 5| 5| 4| 5| 6| 4| 5| 4| 4| 2| 7| 6| 6| 7| 6| 7| 6| 7|
DAY ON TEST | 5| 3| 3| 1| 5| 3| 1| 1| 7| 5| 9| 2| 5| 9| 7| 5| 0| 3| 2| 1| 3| 6| 3| 7| 3|
| 7| 0| 0| 0| 7| 0| 0| 1| 6| 7| 1| 5| 7| 7| 6| 7| 6| 0| 5| 7| 0| 7| 0| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.00% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinar Cell, Cytoplasmic Alteration | 3 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Fibrosis | 4 |
Ulcer | 4 3 |
Mucosa, Hyperplasia | 4 2 1 3 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Chronic | |
Mineralization | |
Ulcer | 3 2 |
Epithelium, Dilatation | 2 2 2 |
__________________________________________________________________________|
Tongue | + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1|
Thrombosis | |
Myocardium, Inflammation, Chronic | 1 1 |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X|
Angiectasis | 2 |
Basophilic Focus | |
Congestion | 2 |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 2 1 2 2 2 1 |
Hypertrophy, Focal | 1 2 3 |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 1 3 2 2 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pigmentation | 2 2 |
Pars Distalis, Angiectasis | 2 1 2 |
Pars Distalis, Cyst | X X X X X X X |
Pars Distalis, Hyperplasia | 3 2 2 2 3 1 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 6| 5| 5| 4| 5| 6| 4| 5| 4| 4| 2| 7| 6| 6| 7| 6| 7| 6| 7|
DAY ON TEST | 5| 3| 3| 1| 5| 3| 1| 1| 7| 5| 9| 2| 5| 9| 7| 5| 0| 3| 2| 1| 3| 6| 3| 7| 3|
| 7| 0| 0| 0| 7| 0| 0| 1| 6| 7| 1| 5| 7| 7| 6| 7| 6| 0| 5| 7| 0| 7| 0| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.00% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Infiltration Cellular,| |
Histiocyte | 2 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 1 1 2 2 1|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Chronic | |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 2 |
Hyperplasia, Cystic | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Vagina | + + M |
Cyst | X |
Exudate | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hypercellularity | |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | 2 2 2 2 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 1 |
Hyperplasia, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 6| 5| 5| 4| 5| 6| 4| 5| 4| 4| 2| 7| 6| 6| 7| 6| 7| 6| 7|
DAY ON TEST | 5| 3| 3| 1| 5| 3| 1| 1| 7| 5| 9| 2| 5| 9| 7| 5| 0| 3| 2| 1| 3| 6| 3| 7| 3|
| 7| 0| 0| 0| 7| 0| 0| 1| 6| 7| 1| 5| 7| 7| 6| 7| 6| 0| 5| 7| 0| 7| 0| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.00% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Mast Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 1 2 2 1 1 1 2 2|
Pigmentation | 2 2 2 2 2 4 3 2 2 2 2 2 2 2 2 2 3 2 3 2|
Lymphoid Follicle, Atrophy | 3 |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | |
Ectopic Parathyroid Gland | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 2 1 2 2 1 1 2 2 3 1 2 1 1 2 2 3 |
Hyperplasia, Lobular | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 |
Exudate | X |
Ulcer | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 |
Calvarium, Osteopetrosis | 3 2 3 3|
Femur, Osteopetrosis | 3 3 2 4|
Sternum, Osteopetrosis | 3 3 2 4|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Developmental Malformation | |
Hemorrhage | |
Hydrocephalus | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | 1 1 1 3|
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 6| 5| 5| 4| 5| 6| 4| 5| 4| 4| 2| 7| 6| 6| 7| 6| 7| 6| 7|
DAY ON TEST | 5| 3| 3| 1| 5| 3| 1| 1| 7| 5| 9| 2| 5| 9| 7| 5| 0| 3| 2| 1| 3| 6| 3| 7| 3|
| 7| 0| 0| 0| 7| 0| 0| 1| 6| 7| 1| 5| 7| 7| 6| 7| 6| 0| 5| 7| 0| 7| 0| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.00% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Exudate | X X X X |
Foreign Body | 3 2 |
Fungus | X X X |
Mucosa, Hyperplasia | 2 1 2 |
Mucosa, Metaplasia, Squamous | 3 2 |
Mucosa, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Hemorrhage | |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 |
Mineralization | 3 3 3 3 3 3 3 3 3 2 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3|
Nephropathy | 2 3 3 3 2 3 2 4 4 2 4 2 2 3 2 2 1 3 2 4 3 2 3 4 3|
Interstitial Tissue, Pigmentation | |
Renal Tubule, Cytoplasmic Alteration | 2 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2 2 |
Transitional Epithelium, Hyperplasia | 1 1 2 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 5| 6| 7| 6| 6| 5| 6| 7| 4| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 5|
DAY ON TEST | 0| 3| 5| 9| 5| 6| 0| 4| 2| 5| 8| 3| 5| 6| 3| 3| 0| 0| 5| 3| 3| 1| 2| 9| 9|
| 3| 1| 7| 1| 5| 6| 3| 3| 4| 1| 5| 0| 7| 6| 0| 0| 8| 5| 7| 0| 6| 0| 4| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.00% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
Ulcer | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X|
Eosinophilic Focus | |
Granuloma | 2 3 1 1 1 1 1 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2 3 2 |
Hyperplasia, Lymphoid | 1 |
Inflammation, Subacute | 1 1 1 |
Mixed Cell Focus | X |
Thrombosis | X |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 1 1 3 1 1 |
Centrilobular, Atrophy | 2 3 1 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | 3 |
Kupffer Cell, Pigmentation | 2 |
Lobules, Necrosis | 1 1 1 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 1 4 2 2 |
Cyst | |
Ectopic Liver | X |
Acinar Cell, Cytoplasmic Alteration | 2 3 3 |
__________________________________________________________________________|
Pharynx | +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 5| 6| 7| 6| 6| 5| 6| 7| 4| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 5|
DAY ON TEST | 0| 3| 5| 9| 5| 6| 0| 4| 2| 5| 8| 3| 5| 6| 3| 3| 0| 0| 5| 3| 3| 1| 2| 9| 9|
| 3| 1| 7| 1| 5| 6| 3| 3| 4| 1| 5| 0| 7| 6| 0| 0| 8| 5| 7| 0| 6| 0| 4| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.00% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinar Cell, Cytoplasmic Alteration | 3 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Fibrosis | |
Ulcer | 2 2 3 2 |
Mucosa, Hyperplasia | 3 4 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4 1 2 1 2 |
Inflammation, Chronic | 2 |
Mineralization | 1 |
Ulcer | 3 |
Epithelium, Dilatation | 1 2 |
__________________________________________________________________________|
Tongue | + + |
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 |
Thrombosis | X |
Myocardium, Inflammation, Chronic | |
Myocardium, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X |
Angiectasis | 2 2 |
Basophilic Focus | X |
Congestion | 3 |
Hyperplasia, Diffuse | 3 |
Hyperplasia, Focal | 1 1 |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 1 1 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 1 2 |
Pars Distalis, Angiectasis | 3 3 3 |
Pars Distalis, Cyst | X X X X X X X|
Pars Distalis, Hyperplasia | 3 3 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 5| 6| 7| 6| 6| 5| 6| 7| 4| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 5|
DAY ON TEST | 0| 3| 5| 9| 5| 6| 0| 4| 2| 5| 8| 3| 5| 6| 3| 3| 0| 0| 5| 3| 3| 1| 2| 9| 9|
| 3| 1| 7| 1| 5| 6| 3| 3| 4| 1| 5| 0| 7| 6| 0| 0| 8| 5| 7| 0| 6| 0| 4| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.00% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Infiltration Cellular,| |
Histiocyte | |
Pars Intermedia, Angiectasis | 2 3 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia | 2 2 1 1 1 1 |
Follicle, Cyst | X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 1 |
Hyperplasia, Cystic | |
Pigmentation | 1 2 |
__________________________________________________________________________|
Vagina | + + M + |
Cyst | |
Exudate | X |
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hypercellularity | 2 |
Myelofibrosis | 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | |
Hyperplasia, Plasma Cell | 2 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 5| 6| 7| 6| 6| 5| 6| 7| 4| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 5|
DAY ON TEST | 0| 3| 5| 9| 5| 6| 0| 4| 2| 5| 8| 3| 5| 6| 3| 3| 0| 0| 5| 3| 3| 1| 2| 9| 9|
| 3| 1| 7| 1| 5| 6| 3| 3| 4| 1| 5| 0| 7| 6| 0| 0| 8| 5| 7| 0| 6| 0| 4| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.00% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 1 2 |
Hematopoietic Cell Proliferation | 2 2 1 2 3 1|
Pigmentation | 2 3 2 2 2 3 3 2 2 2 3 2 2 2 3 2|
Lymphoid Follicle, Atrophy | |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Ectopic Parathyroid Gland | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 1 1 2 2 1 2 2 2 1 2 2 1 2 1 2 2 1 1 1 1 3|
Hyperplasia, Lobular | 3 1 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 |
Exudate | |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 1|
Calvarium, Osteopetrosis | 2 3 3 3 2|
Femur, Osteopetrosis | 3 3 3|
Sternum, Osteopetrosis | 3 3 3|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X |
Developmental Malformation | |
Hemorrhage | 3 2 |
Hydrocephalus | 2 2 2 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Histiocyte | 2 1 2 2 2 1 1 1 1|
Inflammation, Subacute | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 5| 5| 6| 7| 6| 6| 5| 6| 7| 4| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 5|
DAY ON TEST | 0| 3| 5| 9| 5| 6| 0| 4| 2| 5| 8| 3| 5| 6| 3| 3| 0| 0| 5| 3| 3| 1| 2| 9| 9|
| 3| 1| 7| 1| 5| 6| 3| 3| 4| 1| 5| 0| 7| 6| 0| 0| 8| 5| 7| 0| 6| 0| 4| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.00% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Exudate | X X X X X X X X |
Foreign Body | 2 3 2 |
Fungus | X X X |
Mucosa, Hyperplasia | 3 2 3 2 |
Mucosa, Metaplasia, Squamous | 2 1 |
Mucosa, Necrosis | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 1 3 3 |
Hemorrhage | 3 |
Retina, Atrophy | 4 3 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 2 1 1 1 1|
Mineralization | 2 3 3 3 3 3 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2|
Nephropathy | 3 2 2 3 3 4 4 1 3 2 3 3 2 3 2 3 4 3 1 2 3 2 1 2 3|
Interstitial Tissue, Pigmentation | |
Renal Tubule, Cytoplasmic Alteration | 3 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2 2 2 |
Transitional Epithelium, Hyperplasia | 2 1 1 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 6| 6| 4| 5| 7| 7| | |
DAY ON TEST | 2| 5| 1| 3| 9| 8| 5| 9| 2| 0| | |
| 5| 7| 7| 0| 3| 5| 7| 0| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.00% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | X | 6 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Erosion | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 4 2.5|
Basophilic Focus | X X X X X X X X | 46 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X | 1 |
Granuloma | 3 | 17 1.5|
Hematopoietic Cell Proliferation | | 3 1.7|
Hepatodiaphragmatic Nodule | X X X X X | 15 |
Hyperplasia, Focal | | 5 2.4|
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Subacute | | 6 1.2|
Mixed Cell Focus | | 2 |
Thrombosis | | 1 |
Bile Duct, Cyst | X | 1 |
Bile Duct, Hyperplasia | 3 1 | 17 1.4|
Centrilobular, Atrophy | 3 | 7 2.3|
Centrilobular, Necrosis | 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 | 7 2.3|
Kupffer Cell, Hyperplasia | 3 | 2 3.0|
Kupffer Cell, Pigmentation | 3 2 | 5 2.2|
Lobules, Necrosis | | 7 1.3|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Accessory Spleen | | 1 |
Fat, Necrosis | 3 | 5 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | 3 | 23 1.7|
Cyst | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 6| 6| 4| 5| 7| 7| | |
DAY ON TEST | 2| 5| 1| 3| 9| 8| 5| 9| 2| 0| | |
| 5| 7| 7| 0| 3| 5| 7| 0| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.00% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ectopic Liver | | 1 |
Acinar Cell, Cytoplasmic Alteration | 2 | 9 2.7|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | 2 | 3 2.0|
Acinar Cell, Cytoplasmic Alteration | 3 | 5 2.8|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 2 2.5|
Fibrosis | 2 | 2 3.0|
Ulcer | 4 1 3 | 9 2.7|
Mucosa, Hyperplasia | 3 3 | 12 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | 3 2 | 8 2.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | | 1 1.0|
Ulcer | | 3 2.7|
Epithelium, Dilatation | | 5 1.8|
__________________________________________________________________________|____________|
Tongue | | 3 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 1 1 1 | 12 1.0|
Thrombosis | | 1 |
Myocardium, Inflammation, Chronic | | 2 1.0|
Myocardium, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X | 15 |
Angiectasis | 3 | 4 2.3|
Basophilic Focus | | 1 |
Congestion | | 2 2.5|
Hyperplasia, Diffuse | 3 | 2 3.0|
Hyperplasia, Focal | 1 | 9 1.4|
Hypertrophy, Focal | | 3 2.0|
Vacuolization Cytoplasmic, Diffuse | 4 | 1 4.0|
Vacuolization Cytoplasmic, Focal | 1 1 | 13 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + I + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 6| 6| 4| 5| 7| 7| | |
DAY ON TEST | 2| 5| 1| 3| 9| 8| 5| 9| 2| 0| | |
| 5| 7| 7| 0| 3| 5| 7| 0| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.00% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pigmentation | 2 | 6 1.8|
Pars Distalis, Angiectasis | | 6 2.3|
Pars Distalis, Cyst | X X X X X | 19 |
Pars Distalis, Hyperplasia | 1 2 2 1 1 | 18 1.9|
Pars Distalis, Infiltration Cellular,| | |
Histiocyte | | 1 2.0|
Pars Intermedia, Angiectasis | | 3 2.3|
Pars Intermedia, Cyst | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | | 2 1.0|
Ultimobranchial Cyst | | 3 |
C-Cell, Hyperplasia | 1 | 13 1.3|
Follicle, Cyst | X X | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Hyperplasia | | 4 2.0|
Inflammation, Chronic | | 2 2.0|
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | X X X X X | 17 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | 2 | 5 1.8|
Hyperplasia, Cystic | | 1 2.0|
Pigmentation | | 3 1.7|
__________________________________________________________________________|____________|
Vagina | + | 6 |
Cyst | | 1 |
Exudate | | 1 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 6| 6| 4| 5| 7| 7| | |
DAY ON TEST | 2| 5| 1| 3| 9| 8| 5| 9| 2| 0| | |
| 5| 7| 7| 0| 3| 5| 7| 0| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.00% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Congestion | 3 | 1 3.0|
Hypercellularity | | 1 2.0|
Myelofibrosis | 4 2 | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node | + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Ectasia | 2 | 2 2.0|
Hemorrhage | | 2 1.5|
Hyperplasia, Lymphoid | | 4 2.3|
Hyperplasia, Plasma Cell | 2 2 2 | 12 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Ectasia | | 1 2.0|
Hemorrhage | 1 1 | 3 1.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Infiltration Cellular, Mast Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 3 | 5 2.4|
Hematopoietic Cell Proliferation | 1 1 | 16 1.6|
Pigmentation | 2 3 3 2 3 2 3 3 | 44 2.3|
Lymphoid Follicle, Atrophy | 3 | 2 3.0|
Red Pulp, Atrophy | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + | 58 |
Cyst | | 1 |
Ectopic Parathyroid Gland | X | 1 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | 2 2 2 3 3 2 2 3 1 2 | 51 1.7|
Hyperplasia, Lobular | 3 | 6 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 4 2.5|
Exudate | | 1 |
Ulcer | | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | | 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 6| 6| 4| 5| 7| 7| | |
DAY ON TEST | 2| 5| 1| 3| 9| 8| 5| 9| 2| 0| | |
| 5| 7| 7| 0| 3| 5| 7| 0| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.00% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Calvarium, Osteopetrosis | 3 | 10 2.7|
Femur, Osteopetrosis | 4 | 8 3.1|
Sternum, Osteopetrosis | 4 | 8 3.1|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X X | 10 |
Developmental Malformation | X | 1 |
Hemorrhage | | 2 2.5|
Hydrocephalus | 2 | 4 2.0|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 17 1.4|
Inflammation, Subacute | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X X X | 15 |
Foreign Body | 2 2 | 7 2.3|
Fungus | X X X | 9 |
Mucosa, Hyperplasia | 2 | 8 2.1|
Mucosa, Metaplasia, Squamous | 2 1 1 | 7 1.7|
Mucosa, Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Cataract | | 4 2.5|
Hemorrhage | | 1 3.0|
Retina, Atrophy | | 4 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 1 1 1 1 | 17 1.1|
Mineralization | 2 3 3 2 3 3 3 3 3 3 | 60 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 6| 4| 6| 7| 6| 6| 4| 5| 7| 7| | |
DAY ON TEST | 2| 5| 1| 3| 9| 8| 5| 9| 2| 0| | |
| 5| 7| 7| 0| 3| 5| 7| 0| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.00% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 2 1 3 4 3 4 2 4 4 4 | 60 2.7|
Interstitial Tissue, Pigmentation | 3 | 1 3.0|
Renal Tubule, Cytoplasmic Alteration | 3 | 4 2.5|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
Renal Tubule, Pigmentation | | 5 2.0|
Transitional Epithelium, Hyperplasia | 2 2 1 1 | 17 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 5| 2| 6| 5| 7| 6| 5| 4| 6| 6| 5| 7| 4| 7| 5| 4| 5| 6| 7| 6| 5| 5| 4| 5|
DAY ON TEST | 9| 5| 8| 9| 8| 2| 4| 9| 5| 0| 1| 8| 2| 5| 2| 5| 5| 9| 2| 2| 6| 8| 7| 5| 0|
| 4| 3| 8| 4| 8| 9| 5| 5| 6| 3| 7| 6| 9| 6| 9| 3| 6| 4| 3| 9| 9| 9| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Edema | |
Erosion | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Mucosa, Hyperplasia, Diffuse | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Fibrosis | |
Inflammation, Chronic | |
Metaplasia, Osseous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X |
Clear Cell Focus | X X X |
Congestion | |
Degeneration, Cystic | 1 1 1 1 |
Eosinophilic Focus | |
Granuloma | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 2 2 4 |
Hyperplasia, Lymphoid | |
Inflammation, Subacute | 1 |
Mixed Cell Focus | X X X X |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 3 1 1 2 2 1 1 2 1 1 1 2 1 4 1 1 1 3 1 3|
Centrilobular, Atrophy | 2 2 3 2 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 2 3|
Kupffer Cell, Pigmentation | 2 |
Lobules, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Hemorrhage | 4 |
Fat, Necrosis | 2 2 2 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 5| 2| 6| 5| 7| 6| 5| 4| 6| 6| 5| 7| 4| 7| 5| 4| 5| 6| 7| 6| 5| 5| 4| 5|
DAY ON TEST | 9| 5| 8| 9| 8| 2| 4| 9| 5| 0| 1| 8| 2| 5| 2| 5| 5| 9| 2| 2| 6| 8| 7| 5| 0|
| 4| 3| 8| 4| 8| 9| 5| 5| 6| 3| 7| 6| 9| 6| 9| 3| 6| 4| 3| 9| 9| 9| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | 3 3 1 3 2 3 3 2 1 2 1 1 1 3 1|
Cyst | |
Fibrosis | 3 |
Focal Cellular Change | |
Hyperplasia, Lymphoid | |
Acinar Cell, Cytoplasmic Alteration | 3 3 3 |
Acinar Cell, Hyperplasia, Focal | 2 2 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Acinar Cell, Cytoplasmic Alteration | 3 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 3 |
Erosion | 1 |
Hyperplasia | 1 |
Inflammation, Subacute | |
Ulcer | 3 3 |
Mucosa, Hyperplasia | 3 2 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Edema | 2 2 2 |
Erosion | 2 2 1 3 3 2 3|
Inflammation, Chronic | |
Mineralization | 3 2 |
Ulcer | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Hypertrophy | |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 3 3 1 2 2 2 2 3 3 1 2 |
Thrombosis | X|
Myocardium, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X |
Atrophy | 3 |
Congestion | 4 |
Cyst | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 |
Hyperplasia, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 5| 2| 6| 5| 7| 6| 5| 4| 6| 6| 5| 7| 4| 7| 5| 4| 5| 6| 7| 6| 5| 5| 4| 5|
DAY ON TEST | 9| 5| 8| 9| 8| 2| 4| 9| 5| 0| 1| 8| 2| 5| 2| 5| 5| 9| 2| 2| 6| 8| 7| 5| 0|
| 4| 3| 8| 4| 8| 9| 5| 5| 6| 3| 7| 6| 9| 6| 9| 3| 6| 4| 3| 9| 9| 9| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | 1 3 1 1 1 |
Hypertrophy, Focal | 2 2 |
Pigmentation | 3 |
Vacuolization Cytoplasmic, Diffuse | 3 4 2 |
Vacuolization Cytoplasmic, Focal | 1 1 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 1 2 1 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 1 3 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | |
Pars Nervosa, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Infiltration Cellular, Histiocyte | 2 |
C-Cell, Hyperplasia | 2 1 2 1 |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X X X X |
Hypospermia | X X X X X X X X X X X X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | |
Inflammation, Chronic | 1 2 1 1 2 2 2 2 2 2 |
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 3 2 3 |
Ectasia | |
Fibrosis | 2 |
Hyperplasia, Lymphoid | 2 2 2 2 |
Inflammation, Suppurative | 1 3 2 3 2 1 2 2 3 2 2 2 2 3 2 3 3 3 4 2 1 2 2|
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 5| 2| 6| 5| 7| 6| 5| 4| 6| 6| 5| 7| 4| 7| 5| 4| 5| 6| 7| 6| 5| 5| 4| 5|
DAY ON TEST | 9| 5| 8| 9| 8| 2| 4| 9| 5| 0| 1| 8| 2| 5| 2| 5| 5| 9| 2| 2| 6| 8| 7| 5| 0|
| 4| 3| 8| 4| 8| 9| 5| 5| 6| 3| 7| 6| 9| 6| 9| 3| 6| 4| 3| 9| 9| 9| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Spermatocele | X |
Interstitial Cell, Hyperplasia | 2 1 2 |
Seminiferous Tubule, Atrophy | 3 4 3 1 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Mediastinal, Hemorrhage | 3 2 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Pigmentation | 3 |
Pancreatic, Ectasia | 2 |
Renal, Hemorrhage | 2 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 |
Hemorrhage | 1 3 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 2 2 2 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrosis | 2 2 3 |
Hematopoietic Cell Proliferation | 2 2 3 |
Infiltration Cellular, Histiocyte | |
Necrosis | 4 3 |
Pigmentation | 2 2 3 2 2 3 2 |
Lymphoid Follicle, Atrophy | 2 |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | M + + + + + M + + + + + M + + + + + + + + I + + +|
Congestion | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 3 4 2 2 1 2 4 1|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 5| 2| 6| 5| 7| 6| 5| 4| 6| 6| 5| 7| 4| 7| 5| 4| 5| 6| 7| 6| 5| 5| 4| 5|
DAY ON TEST | 9| 5| 8| 9| 8| 2| 4| 9| 5| 0| 1| 8| 2| 5| 2| 5| 5| 9| 2| 2| 6| 8| 7| 5| 0|
| 4| 3| 8| 4| 8| 9| 5| 5| 6| 3| 7| 6| 9| 6| 9| 3| 6| 4| 3| 9| 9| 9| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Lobular | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 |
Cyst Epithelial Inclusion | |
Exudate | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 2 2 3 |
Femur, Osteopetrosis | 2 |
Sternum, Osteopetrosis | 1 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X X |
Hemorrhage | |
Hydrocephalus | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Histiocyte | 2 1 2 2 2 1 |
Inflammation, Subacute | |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 3 3 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X X|
Foreign Body | 2 2 2 3 2|
Fungus | X X X X X X X|
Mucosa, Hyperplasia | 2 2 2 2 2 3 2 |
Mucosa, Metaplasia, Squamous | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 3 3 |
Retina, Atrophy | 4 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 5| 2| 6| 5| 7| 6| 5| 4| 6| 6| 5| 7| 4| 7| 5| 4| 5| 6| 7| 6| 5| 5| 4| 5|
DAY ON TEST | 9| 5| 8| 9| 8| 2| 4| 9| 5| 0| 1| 8| 2| 5| 2| 5| 5| 9| 2| 2| 6| 8| 7| 5| 0|
| 4| 3| 8| 4| 8| 9| 5| 5| 6| 3| 7| 6| 9| 6| 9| 3| 6| 4| 3| 9| 9| 9| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 1 1 1 1 1 1 1 2 1 1 1|
Nephropathy | 2 4 2 3 4 3 4 4 3 3 3 2 3 2 3 2 2 3 4 3 4 3 3 2 2|
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | 4 3 3 2|
Transitional Epithelium, Hyperplasia | 2 1 2 2 1 1 2 1 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | 2 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 6| 7| 5| 5| 6| 7| 4| 6| 7| 7| 6| 4| 5| 5| 6| 4| 6| 7| 6| 6| 4| 5| 5| 6|
DAY ON TEST | 6| 4| 2| 2| 5| 3| 2| 5| 0| 2| 2| 9| 5| 2| 7| 7| 5| 9| 2| 7| 5| 5| 6| 5| 3|
| 2| 6| 9| 6| 3| 0| 0| 6| 4| 9| 9| 2| 6| 6| 3| 2| 6| 8| 9| 8| 7| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | I + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Edema | 2 |
Erosion | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Mucosa, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Fibrosis | |
Inflammation, Chronic | |
Metaplasia, Osseous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X |
Clear Cell Focus | X X|
Congestion | 4 |
Degeneration, Cystic | 1 2 3 2 2 2 |
Eosinophilic Focus | X X |
Granuloma | 1 1 |
Hematopoietic Cell Proliferation | 2 2 2 |
Hepatodiaphragmatic Nodule | X X X X X X X|
Hyperplasia, Focal | 3 2 1 2 3|
Hyperplasia, Lymphoid | |
Inflammation, Subacute | |
Mixed Cell Focus | X |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 2 1 2 1 3 1 3 2 1 2 1 2 2 1 1 1 3 3 3 3 2|
Centrilobular, Atrophy | 3 3 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 3 1 3 1 2 |
Kupffer Cell, Pigmentation | 3 2 |
Lobules, Necrosis | 3 1 3|
__________________________________________________________________________|
Mesentery | + |
Fat, Hemorrhage | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 6| 7| 5| 5| 6| 7| 4| 6| 7| 7| 6| 4| 5| 5| 6| 4| 6| 7| 6| 6| 4| 5| 5| 6|
DAY ON TEST | 6| 4| 2| 2| 5| 3| 2| 5| 0| 2| 2| 9| 5| 2| 7| 7| 5| 9| 2| 7| 5| 5| 6| 5| 3|
| 2| 6| 9| 6| 3| 0| 0| 6| 4| 9| 9| 2| 6| 6| 3| 2| 6| 8| 9| 8| 7| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | 3 3 2 2 2 2 1 2 3 1 1 1 1 1|
Cyst | X |
Fibrosis | |
Focal Cellular Change | X |
Hyperplasia, Lymphoid | 1 |
Acinar Cell, Cytoplasmic Alteration | 3 2 2 |
Acinar Cell, Hyperplasia, Focal | 2 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Acinar Cell, Cytoplasmic Alteration | 4 3 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 |
Erosion | 2 |
Hyperplasia | |
Inflammation, Subacute | 2 |
Ulcer | 4 2 3 2 |
Mucosa, Hyperplasia | 3 2 3 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Edema | 2 2 2 |
Erosion | 3 3 3 |
Inflammation, Chronic | 2 |
Mineralization | 2 3 |
Ulcer | 4|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + +|
Hypertrophy | 3|
Inflammation, Chronic Active | 1 1 3|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 3 1 2|
Thrombosis | |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X |
Atrophy | |
Congestion | |
Cyst | X |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Hyperplasia, Diffuse | 2 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 6| 7| 5| 5| 6| 7| 4| 6| 7| 7| 6| 4| 5| 5| 6| 4| 6| 7| 6| 6| 4| 5| 5| 6|
DAY ON TEST | 6| 4| 2| 2| 5| 3| 2| 5| 0| 2| 2| 9| 5| 2| 7| 7| 5| 9| 2| 7| 5| 5| 6| 5| 3|
| 2| 6| 9| 6| 3| 0| 0| 6| 4| 9| 9| 2| 6| 6| 3| 2| 6| 8| 9| 8| 7| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | 2|
Hypertrophy, Focal | 2 1 |
Pigmentation | 3 |
Vacuolization Cytoplasmic, Diffuse | 3 2 |
Vacuolization Cytoplasmic, Focal | 2 2 3 2 3 2 2 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 3 2 2 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 3 3 1 1|
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | X X |
Pars Nervosa, Hyperplasia | 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 |
Infiltration Cellular, Histiocyte | |
C-Cell, Hyperplasia | 1 1 1 1 1 1 |
Follicle, Cyst | X X X X |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X X X X X X |
Hypospermia | X X X X X X X X X X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 |
Hyperplasia | |
Inflammation, Chronic | 2 2 2 2 1 2 2 1 2 3 |
Inflammation, Suppurative | 2 2 1 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 3 |
Ectasia | 3 3 2 2 |
Fibrosis | 2 2 |
Hyperplasia, Lymphoid | 1 2 1 1 1 1 |
Inflammation, Suppurative | 2 2 3 3 3 3 3 3 2 2 2 2 3 2 3 2 3 3 2 3 2 3|
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 6| 7| 5| 5| 6| 7| 4| 6| 7| 7| 6| 4| 5| 5| 6| 4| 6| 7| 6| 6| 4| 5| 5| 6|
DAY ON TEST | 6| 4| 2| 2| 5| 3| 2| 5| 0| 2| 2| 9| 5| 2| 7| 7| 5| 9| 2| 7| 5| 5| 6| 5| 3|
| 2| 6| 9| 6| 3| 0| 0| 6| 4| 9| 9| 2| 6| 6| 3| 2| 6| 8| 9| 8| 7| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Spermatocele | |
Interstitial Cell, Hyperplasia | 1 1 1 1 2 2 1|
Seminiferous Tubule, Atrophy | 2 1 4 4 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Myelofibrosis | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Pigmentation | |
Pancreatic, Ectasia | |
Renal, Hemorrhage | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 2 3 2 2 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrosis | 3 3 2 2 3 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | |
Necrosis | 4 |
Pigmentation | 2 2 2 2 2 2 2 2 3|
Lymphoid Follicle, Atrophy | 2|
Red Pulp, Atrophy | 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + I + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + M + I + +|
Hyperplasia, Cystic | 2 3 2 3 1 2 4 2 3 2 1 3|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 6| 7| 5| 5| 6| 7| 4| 6| 7| 7| 6| 4| 5| 5| 6| 4| 6| 7| 6| 6| 4| 5| 5| 6|
DAY ON TEST | 6| 4| 2| 2| 5| 3| 2| 5| 0| 2| 2| 9| 5| 2| 7| 7| 5| 9| 2| 7| 5| 5| 6| 5| 3|
| 2| 6| 9| 6| 3| 0| 0| 6| 4| 9| 9| 2| 6| 6| 3| 2| 6| 8| 9| 8| 7| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Cyst Epithelial Inclusion | X |
Exudate | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 2 2 |
Femur, Osteopetrosis | |
Sternum, Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X |
Hemorrhage | 2 |
Hydrocephalus | 2 2 2 1 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1|
Inflammation, Subacute | 1 |
Metaplasia, Osseous | 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X X|
Foreign Body | 2 2 1 2 3 2 2 2 |
Fungus | X X X X X X|
Mucosa, Hyperplasia | 2 2 2 2 2 2 2 3 2 2 2 2 2 2|
Mucosa, Metaplasia, Squamous | 1 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 6| 7| 5| 5| 6| 7| 4| 6| 7| 7| 6| 4| 5| 5| 6| 4| 6| 7| 6| 6| 4| 5| 5| 6|
DAY ON TEST | 6| 4| 2| 2| 5| 3| 2| 5| 0| 2| 2| 9| 5| 2| 7| 7| 5| 9| 2| 7| 5| 5| 6| 5| 3|
| 2| 6| 9| 6| 3| 0| 0| 6| 4| 9| 9| 2| 6| 6| 3| 2| 6| 8| 9| 8| 7| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy | 2 4 3 3 3 2 3 2 2 3 2 4 2 3 3 3 3 3 4 3 2 2 2 4 2|
Renal Tubule, Hyperplasia | 2 2 |
Renal Tubule, Pigmentation | 3 3 |
Transitional Epithelium, Hyperplasia | 3 1 3 1 1 2 1 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 0| 4| 7| 6| 7| 4| 6| 6| 6| 7| | |
DAY ON TEST | 2| 5| 2| 2| 2| 5| 1| 1| 3| 2| | |
| 0| 6| 9| 2| 0| 6| 7| 4| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
Edema | | 1 2.0|
Erosion | | 1 2.0|
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 58 |
Erosion | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 1 2.0|
Mucosa, Hyperplasia, Diffuse | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
Fibrosis | 3 | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Metaplasia, Osseous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 3 1.3|
Basophilic Focus | X X | 13 |
Clear Cell Focus | X | 6 |
Congestion | | 1 4.0|
Degeneration, Cystic | 2 | 11 1.6|
Eosinophilic Focus | | 2 |
Granuloma | 1 | 3 1.0|
Hematopoietic Cell Proliferation | | 3 2.0|
Hepatodiaphragmatic Nodule | X | 10 |
Hyperplasia, Focal | 3 | 9 2.4|
Hyperplasia, Lymphoid | 1 | 1 1.0|
Inflammation, Subacute | | 1 1.0|
Mixed Cell Focus | X | 6 |
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | 2 1 1 1 2 3 1 | 48 1.8|
Centrilobular, Atrophy | 3 | 9 2.6|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 | 16 2.2|
Kupffer Cell, Pigmentation | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 0| 4| 7| 6| 7| 4| 6| 6| 6| 7| | |
DAY ON TEST | 2| 5| 2| 2| 2| 5| 1| 1| 3| 2| | |
| 0| 6| 9| 2| 0| 6| 7| 4| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lobules, Necrosis | | 4 2.3|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Hemorrhage | | 1 4.0|
Fat, Necrosis | | 5 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | 1 2 1 1 2 | 34 1.8|
Cyst | | 1 |
Fibrosis | | 1 3.0|
Focal Cellular Change | | 1 |
Hyperplasia, Lymphoid | | 1 1.0|
Acinar Cell, Cytoplasmic Alteration | 3 3 | 8 2.8|
Acinar Cell, Hyperplasia, Focal | 2 1 | 10 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | | 2 1.5|
Acinar Cell, Cytoplasmic Alteration | | 5 3.4|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | 3 | 4 2.8|
Erosion | | 2 1.5|
Hyperplasia | | 1 1.0|
Inflammation, Subacute | 2 | 2 2.0|
Ulcer | 4 | 7 3.0|
Mucosa, Hyperplasia | 3 2 3 | 12 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Edema | | 6 2.0|
Erosion | 3 | 11 2.5|
Inflammation, Chronic | | 1 2.0|
Mineralization | | 4 2.5|
Ulcer | 3 | 2 3.5|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 6 |
Hypertrophy | 3 | 2 3.0|
Inflammation, Chronic Active | 3 | 6 1.7|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 2 1 2 1 | 26 1.9|
Thrombosis | | 1 |
Myocardium, Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 0| 4| 7| 6| 7| 4| 6| 6| 6| 7| | |
DAY ON TEST | 2| 5| 2| 2| 2| 5| 1| 1| 3| 2| | |
| 0| 6| 9| 2| 0| 6| 7| 4| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X | 14 |
Atrophy | | 1 3.0|
Congestion | | 1 4.0|
Cyst | | 1 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Diffuse | | 1 2.0|
Hyperplasia, Focal | | 6 1.5|
Hypertrophy, Focal | | 4 1.8|
Pigmentation | 3 | 3 3.0|
Vacuolization Cytoplasmic, Diffuse | 2 | 6 2.7|
Vacuolization Cytoplasmic, Focal | 2 1 | 16 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 3 2 | 22 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 2 | 5 1.6|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 60 |
Hyperplasia | 3 2 | 8 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + | 59 |
Pars Distalis, Angiectasis | 1 | 2 1.5|
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia | 2 1 1 | 9 1.8|
Pars Intermedia, Angiectasis | | 1 2.0|
Pars Intermedia, Cyst | | 2 |
Pars Nervosa, Hyperplasia | 1 | 4 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | | 4 1.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
C-Cell, Hyperplasia | 1 | 11 1.2|
Follicle, Cyst | X | 7 |
Follicular Cell, Hyperplasia | 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 0| 4| 7| 6| 7| 4| 6| 6| 6| 7| | |
DAY ON TEST | 2| 5| 2| 2| 2| 5| 1| 1| 3| 2| | |
| 0| 6| 9| 2| 0| 6| 7| 4| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atypia Cellular | X X X | 15 |
Hypospermia | X X | 26 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Ectasia | | 2 3.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | 2 2 2 | 23 1.8|
Inflammation, Suppurative | 2 | 7 1.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Corpora Amylacea | 2 | 7 2.4|
Ectasia | | 4 2.5|
Fibrosis | | 3 2.0|
Hyperplasia, Lymphoid | 2 | 11 1.5|
Inflammation, Suppurative | 1 3 2 3 1 3 2 | 52 2.4|
Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Mineralization | 1 | 2 1.5|
Spermatocele | | 1 |
Interstitial Cell, Hyperplasia | 1 | 11 1.4|
Seminiferous Tubule, Atrophy | 3 3 | 14 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Congestion | 4 | 1 4.0|
Myelofibrosis | 1 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 19 |
Mediastinal, Hemorrhage | 3 | 3 2.7|
Mediastinal, Hyperplasia, Plasma Cell| 2 | 1 2.0|
Mediastinal, Pigmentation | | 1 3.0|
Pancreatic, Ectasia | | 1 2.0|
Renal, Hemorrhage | | 1 2.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Ectasia | | 5 2.2|
Hemorrhage | 1 | 4 1.8|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | 2 2 2 2 | 15 2.2|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 0| 4| 7| 6| 7| 4| 6| 6| 6| 7| | |
DAY ON TEST | 2| 5| 2| 2| 2| 5| 1| 1| 3| 2| | |
| 0| 6| 9| 2| 0| 6| 7| 4| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + | 59 |
Ectasia | 4 | 1 4.0|
Hemorrhage | 1 | 3 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Developmental Malformation | | 2 |
Fibrosis | 3 2 4 | 11 2.6|
Hematopoietic Cell Proliferation | 2 | 9 2.1|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Necrosis | | 3 3.7|
Pigmentation | 3 3 2 3 2 | 21 2.3|
Lymphoid Follicle, Atrophy | | 2 2.0|
Red Pulp, Atrophy | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 54 |
Congestion | 3 | 1 3.0|
Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + M + + | 54 |
Hyperplasia, Cystic | 1 3 3 4 | 26 2.3|
Hyperplasia, Lobular | 4 | 2 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | 1 | 4 1.3|
Cyst Epithelial Inclusion | | 1 |
Exudate | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | 3 1 | 10 2.2|
Femur, Osteopetrosis | | 1 2.0|
Sternum, Osteopetrosis | | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X | 19 |
Hemorrhage | | 1 2.0|
Hydrocephalus | | 6 1.8|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 0| 4| 7| 6| 7| 4| 6| 6| 6| 7| | |
DAY ON TEST | 2| 5| 2| 2| 2| 5| 1| 1| 3| 2| | |
| 0| 6| 9| 2| 0| 6| 7| 4| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 2 | 4 2.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 15 1.3|
Inflammation, Subacute | 1 | 2 1.0|
Metaplasia, Osseous | | 2 1.0|
Alveolar Epithelium, Hyperplasia | 3 | 6 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X X X X X X | 30 |
Foreign Body | 2 2 3 | 16 2.1|
Fungus | X X X X | 17 |
Mucosa, Hyperplasia | 2 2 2 3 | 25 2.1|
Mucosa, Metaplasia, Squamous | 3 2 | 6 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Cataract | | 4 3.0|
Retina, Atrophy | | 4 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 1 | 10 1.2|
Mineralization | 1 1 | 27 1.0|
Nephropathy | 3 4 3 4 3 4 2 3 2 | 59 2.9|
Renal Tubule, Hyperplasia | | 3 1.7|
Renal Tubule, Pigmentation | 3 | 7 3.0|
Transitional Epithelium, Hyperplasia | 2 2 2 1 | 25 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 2 3.0|
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 5| 6| 5| 5| 6| 6| 4| 5| 5| 3| 5| 6| 4| 7| 7| 7| 7| 6| 6| 3| 5|
DAY ON TEST | 7| 4| 3| 5| 9| 7| 7| 2| 2| 5| 5| 5| 7| 0| 5| 0| 5| 3| 0| 3| 3| 9| 6| 4| 7|
| 3| 6| 1| 6| 1| 9| 5| 0| 9| 1| 6| 3| 5| 7| 7| 3| 6| 1| 8| 1| 1| 9| 6| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Erosion | 1 |
Ulcer | |
Mucosa, Hyperplasia, Diffuse | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Subacute | 4 |
Mucosa, Hyperplasia, Diffuse | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Mucosa, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | |
Congestion | |
Degeneration, Cystic | 2 3 1 1 |
Eosinophilic Focus | X X |
Granuloma | 1 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 3 2 3 1 1 |
Inflammation, Subacute | 1 |
Mixed Cell Focus | X X X |
Thrombosis | |
Bile Duct, Hyperplasia | 3 3 3 2 2 3 3 1 2 2 4 1 3 1 1 1 2 1 1 2 1|
Centrilobular, Atrophy | 3 2 2 2 |
Centrilobular, Necrosis | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 2 2 1|
Kupffer Cell, Pigmentation | 3 |
Lobules, Necrosis | 3 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy | 1 2 2 1 3 4 1 1 2 1 2 1 4 3 2 |
Hyperplasia, Lymphoid | 2 |
Acinar Cell, Cytoplasmic Alteration | 3 3 2 2|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 5| 6| 5| 5| 6| 6| 4| 5| 5| 3| 5| 6| 4| 7| 7| 7| 7| 6| 6| 3| 5|
DAY ON TEST | 7| 4| 3| 5| 9| 7| 7| 2| 2| 5| 5| 5| 7| 0| 5| 0| 5| 3| 0| 3| 3| 9| 6| 4| 7|
| 3| 6| 1| 6| 1| 9| 5| 0| 9| 1| 6| 3| 5| 7| 7| 3| 6| 1| 8| 1| 1| 9| 6| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinar Cell, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Acinar Cell, Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Erosion | |
Fibrosis | 3 |
Inflammation, Subacute | |
Perforation | |
Ulcer | 3 2 4|
Mucosa, Hyperplasia | 3 3 2 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Edema | 2 |
Erosion | 3 2 |
Inflammation, Chronic | |
Mineralization | |
Ulcer | 3 |
Epithelium, Dilatation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 1 2 1 1 2 1 1 1 1 1 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X|
Basophilic Focus | X X |
Congestion | 3 |
Hematopoietic Cell Proliferation | 1 2 |
Hyperplasia, Focal | 1 2 2 |
Hypertrophy, Focal | 2 |
Pigmentation | |
Vacuolization Cytoplasmic, Diffuse | 3 3 2 |
Vacuolization Cytoplasmic, Focal | 2 2 1 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 2 3 3 2 1 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M M + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 5| 6| 5| 5| 6| 6| 4| 5| 5| 3| 5| 6| 4| 7| 7| 7| 7| 6| 6| 3| 5|
DAY ON TEST | 7| 4| 3| 5| 9| 7| 7| 2| 2| 5| 5| 5| 7| 0| 5| 0| 5| 3| 0| 3| 3| 9| 6| 4| 7|
| 3| 6| 1| 6| 1| 9| 5| 0| 9| 1| 6| 3| 5| 7| 7| 3| 6| 1| 8| 1| 1| 9| 6| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 3 2 3 |
Pars Distalis, Necrosis | |
Pars Intermedia, Angiectasis | 3 |
Pars Intermedia, Cyst | |
Pars Nervosa, Hyperplasia | 1 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
Degeneration, Cystic | 1 |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 1 1 1 |
Follicle, Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X X X |
Hypospermia | X X X X X X X X X X |
__________________________________________________________________________|
Penis | + |
Edema | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Suppurative | |
Necrosis | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 3 2 |
Ectasia | |
Fibrosis | 3 2 3 |
Hyperplasia, Lymphoid | 1 2 3 |
Inflammation, Suppurative | 1 4 3 2 3 2 2 2 3 2 1 3 4 2 4 4 3 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 2 2 1 1 1 |
Seminiferous Tubule, Atrophy | 4 4 3 2 4 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 5| 6| 5| 5| 6| 6| 4| 5| 5| 3| 5| 6| 4| 7| 7| 7| 7| 6| 6| 3| 5|
DAY ON TEST | 7| 4| 3| 5| 9| 7| 7| 2| 2| 5| 5| 5| 7| 0| 5| 0| 5| 3| 0| 3| 3| 9| 6| 4| 7|
| 3| 6| 1| 6| 1| 9| 5| 0| 9| 1| 6| 3| 5| 7| 7| 3| 6| 1| 8| 1| 1| 9| 6| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
Myelofibrosis | 4 2 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Lumbar, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Hemorrhage | |
Pancreatic, Pigmentation | 4 |
Renal, Hemorrhage | 2 |
Renal, Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 2 2 2 |
Fibrosis | |
Hemorrhage | 2 1 1 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 2 3 2 3 2 3 3 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 2 3 2 |
Hyperplasia, Lymphoid | 2 3 |
Pigmentation | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Congestion | 3 |
Developmental Malformation | |
Fibrosis | 3 2 3 1 2 3 2 3 1 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 1 |
Necrosis | 2 |
Pigmentation | 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2|
Lymphoid Follicle, Atrophy | 3 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + I + + + + + + +|
Ectopic Thyroid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 1 2 1 2 3 1 4 2 2|
Hyperplasia, Lobular | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 |
Cyst Epithelial Inclusion | |
Exudate | |
Hyperplasia, Basal Cell | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 5| 6| 5| 5| 6| 6| 4| 5| 5| 3| 5| 6| 4| 7| 7| 7| 7| 6| 6| 3| 5|
DAY ON TEST | 7| 4| 3| 5| 9| 7| 7| 2| 2| 5| 5| 5| 7| 0| 5| 0| 5| 3| 0| 3| 3| 9| 6| 4| 7|
| 3| 6| 1| 6| 1| 9| 5| 0| 9| 1| 6| 3| 5| 7| 7| 3| 6| 1| 8| 1| 1| 9| 6| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 3 2 |
Hyperostosis | |
Necrosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X|
Hemorrhage | 4 |
Hydrocephalus | 2 2 2 |
Mineralization | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Edema | |
Foreign Body | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Subacute | 1 2 2 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X|
Foreign Body | 2 2 3 3|
Fungus | X X X X X X|
Mucosa, Hyperplasia | 2 3 2 2 2 3 2|
Mucosa, Metaplasia, Squamous | 1 |
Mucosa, Necrosis | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cataract | |
Inflammation, Chronic | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 5| 6| 5| 5| 6| 6| 4| 5| 5| 3| 5| 6| 4| 7| 7| 7| 7| 6| 6| 3| 5|
DAY ON TEST | 7| 4| 3| 5| 9| 7| 7| 2| 2| 5| 5| 5| 7| 0| 5| 0| 5| 3| 0| 3| 3| 9| 6| 4| 7|
| 3| 6| 1| 6| 1| 9| 5| 0| 9| 1| 6| 3| 5| 7| 7| 3| 6| 1| 8| 1| 1| 9| 6| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Inflammation, Suppurative | 1 1 1 1 1 1 |
Mineralization | 1 1 2 1 1 3 1 1 1 1 1 1 1 |
Nephropathy | 2 2 3 2 3 4 3 2 3 2 3 2 3 2 3 3 3 4 4 3 4 4 2 4|
Renal Tubule, Hyperplasia | 2 1 1 2 |
Renal Tubule, Pigmentation | 2 3 2 2 2 |
Transitional Epithelium, Hyperplasia | 2 1 2 1 2 2 2 1 1 2 1 2 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Suppurative | 3 1 |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 6| 4| 6| 6| 6| 6| 5| 4| 6| 7| 6| 7| 4| 6| 3| 6| 4| 6| 6| 7| 4| 7| 5| 6|
DAY ON TEST | 3| 2| 5| 2| 7| 0| 9| 9| 5| 1| 2| 5| 3| 5| 9| 9| 7| 5| 0| 0| 0| 5| 2| 1| 3|
| 9| 4| 6| 6| 9| 3| 3| 6| 6| 9| 0| 1| 1| 6| 2| 5| 2| 6| 2| 5| 8| 6| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1 |
Ulcer | 2 |
Mucosa, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Mucosa, Hyperplasia, Diffuse | 3 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Mucosa, Hyperplasia, Diffuse | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X |
Clear Cell Focus | X X X |
Congestion | 3 |
Degeneration, Cystic | 1 2 2|
Eosinophilic Focus | X |
Granuloma | 1 |
Hematopoietic Cell Proliferation | 1|
Hepatodiaphragmatic Nodule | X X X X X X|
Hyperplasia, Focal | 1 2 |
Inflammation, Subacute | 1 |
Mixed Cell Focus | |
Thrombosis | X |
Bile Duct, Hyperplasia | 3 2 1 1 1 4 1 1 2 3 1 1 1 1 4 1 3 1 1 |
Centrilobular, Atrophy | 2 2 2 2 3 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 3 1 4 2 4 3 |
Kupffer Cell, Pigmentation | 1 3 2 1|
Lobules, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | 3 |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 1 3 1 2 3 1 1 3 1 1 3 1|
Hyperplasia, Lymphoid | |
Acinar Cell, Cytoplasmic Alteration | 2 3 4 4 3 2 4 |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 6| 4| 6| 6| 6| 6| 5| 4| 6| 7| 6| 7| 4| 6| 3| 6| 4| 6| 6| 7| 4| 7| 5| 6|
DAY ON TEST | 3| 2| 5| 2| 7| 0| 9| 9| 5| 1| 2| 5| 3| 5| 9| 9| 7| 5| 0| 0| 0| 5| 2| 1| 3|
| 9| 4| 6| 6| 9| 3| 3| 6| 6| 9| 0| 1| 1| 6| 2| 5| 2| 6| 2| 5| 8| 6| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinar Cell, Hyperplasia, Focal | 2 3 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2|
Acinar Cell, Cytoplasmic Alteration | 4 3 4 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 3 3 3 |
Erosion | |
Fibrosis | 3 |
Inflammation, Subacute | 2 |
Perforation | X |
Ulcer | 3 2 3 4 4 3 4 4 3 4 |
Mucosa, Hyperplasia | 3 4 4 3 3 2 3 3 2 4 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Edema | 2 |
Erosion | 1 2 3 |
Inflammation, Chronic | 2 2 |
Mineralization | 1 1 |
Ulcer | 2 2 |
Epithelium, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 1 2 1 2 1 2 2 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X|
Basophilic Focus | |
Congestion | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | |
Hypertrophy, Focal | |
Pigmentation | 3 2 |
Vacuolization Cytoplasmic, Diffuse | 2 2 |
Vacuolization Cytoplasmic, Focal | 2 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 1 3 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 6| 4| 6| 6| 6| 6| 5| 4| 6| 7| 6| 7| 4| 6| 3| 6| 4| 6| 6| 7| 4| 7| 5| 6|
DAY ON TEST | 3| 2| 5| 2| 7| 0| 9| 9| 5| 1| 2| 5| 3| 5| 9| 9| 7| 5| 0| 0| 0| 5| 2| 1| 3|
| 9| 4| 6| 6| 9| 3| 3| 6| 6| 9| 0| 1| 1| 6| 2| 5| 2| 6| 2| 5| 8| 6| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 3 2 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 3 1 2 |
Pars Distalis, Necrosis | 4 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | X X |
Pars Nervosa, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia | 1 1 1 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X |
Hypospermia | X X X X X X X X |
__________________________________________________________________________|
Penis | + |
Edema | 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Inflammation, Chronic | 2 2 2 2 2 2 2 1 2 2 2 |
Inflammation, Suppurative | 2 2 |
Necrosis | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 2 2|
Ectasia | 2 |
Fibrosis | 2 |
Hyperplasia, Lymphoid | 1 2 1 2 |
Inflammation, Suppurative | 3 3 3 3 2 2 2 2 3 2 3 3 2 2 3 2 3 3 2 3 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 2 1 1 3 1 2 2 1|
Seminiferous Tubule, Atrophy | 3 4 4 4 4 4 2 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 6| 4| 6| 6| 6| 6| 5| 4| 6| 7| 6| 7| 4| 6| 3| 6| 4| 6| 6| 7| 4| 7| 5| 6|
DAY ON TEST | 3| 2| 5| 2| 7| 0| 9| 9| 5| 1| 2| 5| 3| 5| 9| 9| 7| 5| 0| 0| 0| 5| 2| 1| 3|
| 9| 4| 6| 6| 9| 3| 3| 6| 6| 9| 0| 1| 1| 6| 2| 5| 2| 6| 2| 5| 8| 6| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Lumbar, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | 3 |
Pancreatic, Pigmentation | |
Renal, Hemorrhage | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 |
Fibrosis | 3 |
Hemorrhage | 2 1 |
Hyperplasia, Lymphoid | 2 3|
Hyperplasia, Plasma Cell | 3 2 2 2 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + I|
Ectasia | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Developmental Malformation | X |
Fibrosis | 3 2 3 4 3 2|
Hematopoietic Cell Proliferation | 2 2 2|
Necrosis | |
Pigmentation | 2 2 2 3 2 2 2 3 3 2 3 3 3 2|
Lymphoid Follicle, Atrophy | 4 |
Red Pulp, Atrophy | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Thyroid | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Cystic | 3 1 3 1 3 2 2 1 3 3 2 2 2 2|
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | X |
Exudate | |
Hyperplasia, Basal Cell | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 6| 4| 6| 6| 6| 6| 5| 4| 6| 7| 6| 7| 4| 6| 3| 6| 4| 6| 6| 7| 4| 7| 5| 6|
DAY ON TEST | 3| 2| 5| 2| 7| 0| 9| 9| 5| 1| 2| 5| 3| 5| 9| 9| 7| 5| 0| 0| 0| 5| 2| 1| 3|
| 9| 4| 6| 6| 9| 3| 3| 6| 6| 9| 0| 1| 1| 6| 2| 5| 2| 6| 2| 5| 8| 6| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 3 2 2 1 1 |
Hyperostosis | 3 3 |
Necrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X X |
Hemorrhage | |
Hydrocephalus | 2 2 2 2 |
Mineralization | 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
Foreign Body | 3|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 3 |
Inflammation, Subacute | 1 |
Inflammation, Suppurative | 2 4|
Alveolar Epithelium, Hyperplasia | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X X X X|
Foreign Body | 2 1 2 2 2 2 2 3 4|
Fungus | X X X X X X X|
Mucosa, Hyperplasia | 1 2 2 2 3 2 2 3 1 2 3|
Mucosa, Metaplasia, Squamous | 1 1 2 2 2 |
Mucosa, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 3 |
Inflammation, Chronic | 2 |
Retina, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 6| 6| 4| 6| 6| 6| 6| 5| 4| 6| 7| 6| 7| 4| 6| 3| 6| 4| 6| 6| 7| 4| 7| 5| 6|
DAY ON TEST | 3| 2| 5| 2| 7| 0| 9| 9| 5| 1| 2| 5| 3| 5| 9| 9| 7| 5| 0| 0| 0| 5| 2| 1| 3|
| 9| 4| 6| 6| 9| 3| 3| 6| 6| 9| 0| 1| 1| 6| 2| 5| 2| 6| 2| 5| 8| 6| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.125% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Inflammation, Suppurative | 1 1 1 1 1 2 1 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 2 2 3 2 4 4 4 2 3 3 4 4 4 3 4 2 3 3 4 3 4 2 3 4 3|
Renal Tubule, Hyperplasia | 1 2 3 |
Renal Tubule, Pigmentation | 3 3 2 |
Transitional Epithelium, Hyperplasia | 2 2 3 2 1 2 1 1 2 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 6| 5| 6| 4| 6| 7| | |
DAY ON TEST | 5| 2| 6| 6| 5| 8| 9| 5| 6| 3| | |
| 6| 4| 2| 9| 6| 4| 4| 6| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + I + + + + + + + | 58 |
Parasite Metazoan | X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + | 53 |
Erosion | | 3 1.0|
Ulcer | | 1 2.0|
Mucosa, Hyperplasia, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 57 |
Inflammation, Subacute | | 1 4.0|
Mucosa, Hyperplasia, Diffuse | | 3 2.3|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + | 58 |
Inflammation, Subacute | | 1 2.0|
Mucosa, Hyperplasia, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.0|
Basophilic Focus | X X X | 19 |
Clear Cell Focus | X | 4 |
Congestion | 3 | 2 3.0|
Degeneration, Cystic | 1 | 8 1.6|
Eosinophilic Focus | | 3 |
Granuloma | | 3 1.3|
Hematopoietic Cell Proliferation | 3 | 3 1.7|
Hepatodiaphragmatic Nodule | | 8 |
Hyperplasia, Focal | | 7 1.9|
Inflammation, Subacute | 2 | 3 1.3|
Mixed Cell Focus | | 3 |
Thrombosis | | 1 |
Bile Duct, Hyperplasia | 1 3 1 1 3 3 2 1 3 | 49 1.9|
Centrilobular, Atrophy | 2 2 2 | 12 2.2|
Centrilobular, Necrosis | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 | 14 2.4|
Kupffer Cell, Pigmentation | 1 2 2 | 8 1.9|
Lobules, Necrosis | 2 | 7 1.6|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 6| 5| 6| 4| 6| 7| | |
DAY ON TEST | 5| 2| 6| 6| 5| 8| 9| 5| 6| 3| | |
| 6| 4| 2| 9| 6| 4| 4| 6| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fat, Necrosis | 2 | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy | 1 1 2 1 3 2 1 | 37 1.9|
Hyperplasia, Lymphoid | | 1 2.0|
Acinar Cell, Cytoplasmic Alteration | | 11 2.9|
Acinar Cell, Hyperplasia, Focal | | 5 2.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | | 2 2.0|
Acinar Cell, Cytoplasmic Alteration | | 5 3.4|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 7 2.7|
Erosion | 2 | 1 2.0|
Fibrosis | 4 | 3 3.3|
Inflammation, Subacute | | 1 2.0|
Perforation | | 1 |
Ulcer | 3 | 14 3.3|
Mucosa, Hyperplasia | 3 | 16 3.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Cyst Epithelial Inclusion | | 1 |
Edema | | 2 2.0|
Erosion | | 5 2.2|
Inflammation, Chronic | 2 | 3 2.0|
Mineralization | 2 | 3 1.3|
Ulcer | | 3 2.3|
Epithelium, Dilatation | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
Inflammation, Chronic Active | | 3 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 2 1 2 1 1 | 30 1.4|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X X | 17 |
Basophilic Focus | | 2 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 6| 5| 6| 4| 6| 7| | |
DAY ON TEST | 5| 2| 6| 6| 5| 8| 9| 5| 6| 3| | |
| 6| 4| 2| 9| 6| 4| 4| 6| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia, Focal | 1 1 | 5 1.4|
Hypertrophy, Focal | | 1 2.0|
Pigmentation | 3 | 3 2.7|
Vacuolization Cytoplasmic, Diffuse | 3 | 6 2.5|
Vacuolization Cytoplasmic, Focal | 3 | 9 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 2 1 2 | 21 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 56 |
Hyperplasia | 2 | 9 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 4.0|
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia | 2 | 7 2.3|
Pars Distalis, Necrosis | | 1 4.0|
Pars Intermedia, Angiectasis | | 1 3.0|
Pars Intermedia, Cyst | | 2 |
Pars Nervosa, Hyperplasia | | 4 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | | 1 1.0|
Ultimobranchial Cyst | | 2 |
C-Cell, Hyperplasia | | 9 1.2|
Follicle, Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atypia Cellular | X X X | 9 |
Hypospermia | X X X X | 22 |
__________________________________________________________________________|____________|
Penis | | 2 |
Edema | | 1 3.0|
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Ectasia | 3 3 | 3 3.0|
Inflammation, Chronic | 1 2 2 | 26 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 6| 5| 6| 4| 6| 7| | |
DAY ON TEST | 5| 2| 6| 6| 5| 8| 9| 5| 6| 3| | |
| 6| 4| 2| 9| 6| 4| 4| 6| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2 2 2 | 5 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Corpora Amylacea | 2 | 7 2.1|
Ectasia | | 1 2.0|
Fibrosis | | 4 2.5|
Hyperplasia, Lymphoid | 1 | 8 1.6|
Inflammation, Suppurative | 2 2 3 3 2 1 1 3 2 | 48 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | | 20 1.4|
Seminiferous Tubule, Atrophy | 3 3 4 | 18 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 1 2.0|
Myelofibrosis | 2 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node | | 11 |
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Mediastinal, Hemorrhage | | 1 3.0|
Pancreatic, Pigmentation | | 1 4.0|
Renal, Hemorrhage | | 1 2.0|
Renal, Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + | 58 |
Ectasia | 2 3 | 9 2.3|
Fibrosis | | 1 3.0|
Hemorrhage | 2 | 6 1.5|
Hyperplasia, Lymphoid | | 3 2.3|
Hyperplasia, Plasma Cell | 3 2 2 | 19 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Ectasia | | 1 3.0|
Hemorrhage | | 4 2.0|
Hyperplasia, Lymphoid | 2 | 4 2.5|
Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Congestion | | 1 3.0|
Developmental Malformation | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 6| 5| 6| 4| 6| 7| | |
DAY ON TEST | 5| 2| 6| 6| 5| 8| 9| 5| 6| 3| | |
| 6| 4| 2| 9| 6| 4| 4| 6| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | 2 4 | 17 2.5|
Hematopoietic Cell Proliferation | 2 | 12 2.0|
Necrosis | 3 | 2 2.5|
Pigmentation | 2 2 2 2 2 | 35 2.2|
Lymphoid Follicle, Atrophy | | 2 3.5|
Red Pulp, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
Ectopic Thyroid | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + M + + | 58 |
Hyperplasia, Cystic | 1 1 3 3 2 | 30 2.1|
Hyperplasia, Lobular | | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | 2 | 3 1.3|
Cyst Epithelial Inclusion | | 1 |
Exudate | X | 1 |
Hyperplasia, Basal Cell | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | 1 2 1 | 14 1.6|
Hyperostosis | | 2 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X X | 18 |
Hemorrhage | | 1 4.0|
Hydrocephalus | 2 2 2 | 10 2.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Edema | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 6| 5| 6| 4| 6| 7| | |
DAY ON TEST | 5| 2| 6| 6| 5| 8| 9| 5| 6| 3| | |
| 6| 4| 2| 9| 6| 4| 4| 6| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.125% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | | 1 3.0|
Hemorrhage | 1 | 2 1.0|
Hyperplasia, Lymphoid | 2 | 3 2.3|
Infiltration Cellular, Histiocyte | 1 3 | 12 1.4|
Inflammation, Subacute | 1 | 5 1.4|
Inflammation, Suppurative | | 2 3.0|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X X X X | 26 |
Foreign Body | 3 2 2 2 | 17 2.3|
Fungus | X X X X | 17 |
Mucosa, Hyperplasia | 3 3 2 2 2 1 | 24 2.2|
Mucosa, Metaplasia, Squamous | 2 2 1 | 9 1.6|
Mucosa, Necrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Mucosa, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | 4 | 3 3.3|
Inflammation, Chronic | | 1 2.0|
Retina, Atrophy | 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hydronephrosis | | 1 2.0|
Inflammation, Suppurative | 1 1 1 1 | 18 1.1|
Mineralization | 1 1 1 1 1 1 | 30 1.1|
Nephropathy | 2 4 2 3 4 4 3 3 3 3 | 59 3.1|
Renal Tubule, Hyperplasia | | 7 1.7|
Renal Tubule, Pigmentation | 3 | 9 2.4|
Transitional Epithelium, Hyperplasia | 2 2 1 2 2 | 32 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 6| 5| 6| 5| 5| 6| 6| 3| 5| 6| 4| 5| 6| 4| 5| 5| 4| 5| 6| 3| 7| 5| 4| 3|
DAY ON TEST | 5| 0| 2| 7| 6| 5| 2| 0| 4| 5| 7| 5| 4| 0| 5| 8| 2| 5| 5| 4| 9| 3| 8| 5| 5|
| 6| 3| 8| 9| 9| 3| 3| 7| 3| 6| 3| 6| 7| 5| 6| 0| 5| 6| 1| 5| 8| 0| 9| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Erosion | 1 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | 2 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X |
Congestion | 2 |
Degeneration, Cystic | 2 2 1 |
Granuloma | 2 1 1 1 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 2 |
Hyperplasia, Lymphoid | 1 |
Inflammation, Subacute | 1 1 1 2 |
Mixed Cell Focus | |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 1 3 1 4 1 1 1 1 1 1 1 1 1 2 1 1 2 3 1 |
Centrilobular, Atrophy | 3 2 2 |
Centrilobular, Necrosis | 3 3|
Hepatocyte, Vacuolization Cytoplasmic| 1 3 3 3 2 |
Kupffer Cell, Pigmentation | 3 1 1 2 |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + +|
Accessory Spleen | |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 1 2 2 2 1 2 4 2 2 2 2|
Focal Cellular Change | |
Hyperplasia, Lymphoid | |
Acinar Cell, Cytoplasmic Alteration | 3 3 3 3 3 |
Acinar Cell, Hyperplasia, Focal | 3 2 2 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 6| 5| 6| 5| 5| 6| 6| 3| 5| 6| 4| 5| 6| 4| 5| 5| 4| 5| 6| 3| 7| 5| 4| 3|
DAY ON TEST | 5| 0| 2| 7| 6| 5| 2| 0| 4| 5| 7| 5| 4| 0| 5| 8| 2| 5| 5| 4| 9| 3| 8| 5| 5|
| 6| 3| 8| 9| 9| 3| 3| 7| 3| 6| 3| 6| 7| 5| 6| 0| 5| 6| 1| 5| 8| 0| 9| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | 1 |
Acinar Cell, Cytoplasmic Alteration | 3 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Fibrosis | |
Ulcer | 4 3 4 4 |
Mucosa, Hyperplasia | 3 4 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 3 3 2|
Mineralization | |
Ulcer | 2 3 3 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 2 1 1 1 1 3 |
Thrombosis | |
Myocardium, Mineralization | 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X X |
Hyperplasia, Focal | 1 2 2 2 |
Hypertrophy, Focal | 1 2 |
Pigmentation | 3 |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 2 2 2 1 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 1 3 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 1 1 |
Pars Intermedia, Cyst | |
Pars Nervosa, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 6| 5| 6| 5| 5| 6| 6| 3| 5| 6| 4| 5| 6| 4| 5| 5| 4| 5| 6| 3| 7| 5| 4| 3|
DAY ON TEST | 5| 0| 2| 7| 6| 5| 2| 0| 4| 5| 7| 5| 4| 0| 5| 8| 2| 5| 5| 4| 9| 3| 8| 5| 5|
| 6| 3| 8| 9| 9| 3| 3| 7| 3| 6| 3| 6| 7| 5| 6| 0| 5| 6| 1| 5| 8| 0| 9| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X X X |
Hypospermia | X X X X X X |
__________________________________________________________________________|
Penis | + |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Inflammation, Chronic | 2 2 2 2 2 1 |
Inflammation, Suppurative | 2 1 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 2 |
Ectasia | |
Fibrosis | |
Hyperplasia, Lymphoid | 1 1 |
Inflammation, Suppurative | 2 3 3 3 1 2 3 3 3 2 3 2 2 2 2 2 3 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Interstitial Cell, Hyperplasia | 1 1 1 2 |
Seminiferous Tubule, Atrophy | 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3|
Myelofibrosis | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Congestion | |
Ectasia | 2 2 |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 6| 5| 6| 5| 5| 6| 6| 3| 5| 6| 4| 5| 6| 4| 5| 5| 4| 5| 6| 3| 7| 5| 4| 3|
DAY ON TEST | 5| 0| 2| 7| 6| 5| 2| 0| 4| 5| 7| 5| 4| 0| 5| 8| 2| 5| 5| 4| 9| 3| 8| 5| 5|
| 6| 3| 8| 9| 9| 3| 3| 7| 3| 6| 3| 6| 7| 5| 6| 0| 5| 6| 1| 5| 8| 0| 9| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 2 3 |
Hyperplasia, Plasma Cell | 2 2 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 2 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrosis | 4 2 3 2 |
Hematopoietic Cell Proliferation | 2 3 3|
Necrosis | |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + I + + + + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 3 3 2 3 2 2 3 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + I + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Cyst Epithelial Inclusion | |
Exudate | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 1 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X X |
Granuloma | |
Hemorrhage | |
Hydrocephalus | 2 2 2 2 3 2 |
Vacuolization Cytoplasmic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 1 2 |
Inflammation, Subacute | |
Leukocytosis | 2|
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 6| 5| 6| 5| 5| 6| 6| 3| 5| 6| 4| 5| 6| 4| 5| 5| 4| 5| 6| 3| 7| 5| 4| 3|
DAY ON TEST | 5| 0| 2| 7| 6| 5| 2| 0| 4| 5| 7| 5| 4| 0| 5| 8| 2| 5| 5| 4| 9| 3| 8| 5| 5|
| 6| 3| 8| 9| 9| 3| 3| 7| 3| 6| 3| 6| 7| 5| 6| 0| 5| 6| 1| 5| 8| 0| 9| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X X X |
Foreign Body | 2 2 3 2 3 2 |
Fungus | X X X X X X X X X X |
Mucosa, Hyperplasia | 2 3 2 4 2 3 4 3 3 |
Mucosa, Metaplasia, Squamous | 2 4 3 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Cataract | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 1 1 |
Mineralization | 1 2 1 1 2 1 2 1 1 2 1 1 1 1 1 2|
Nephropathy | 3 2 3 3 2 3 3 2 2 3 3 3 3 4 3 4 4 3 2 4 2 4 3 2 1|
Renal Tubule, Cytoplasmic Alteration | 3 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Hyperplasia, Oncocytic | 1 |
Renal Tubule, Pigmentation | 3 3 3 |
Transitional Epithelium, Hyperplasia | 2 3 1 3 1 2 3 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Dilatation | |
Inflammation, Subacute | |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 4| 6| 4| 7| 6| 6| 5| 6| 4| 6| 5| 5| 6| 5| 6| 7| 5| 4| 5| 5| 6|
DAY ON TEST | 8| 0| 3| 8| 5| 2| 8| 3| 8| 4| 9| 5| 5| 3| 1| 4| 4| 9| 5| 3| 1| 5| 4| 7| 3|
| 2| 3| 7| 9| 6| 4| 4| 0| 5| 3| 5| 3| 6| 7| 2| 5| 3| 5| 0| 0| 0| 6| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Erosion | 2 2 2 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + I + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Basophilic Focus | X X X X X X X X X X X|
Clear Cell Focus | X |
Congestion | |
Degeneration, Cystic | 2 2 3 2 |
Granuloma | 1 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2 1 |
Hyperplasia, Lymphoid | |
Inflammation, Subacute | |
Mixed Cell Focus | X X |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 1 1 3 3 2 3 2 1 1 2|
Centrilobular, Atrophy | 3 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 4 2 2 2 2 2 3 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 2 1 4 |
__________________________________________________________________________|
Mesentery | + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 3 1 2 3 2 2 1 1 4 3 1 2 |
Focal Cellular Change | X |
Hyperplasia, Lymphoid | |
Acinar Cell, Cytoplasmic Alteration | 2 3 2 3 4 2 |
Acinar Cell, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 4| 6| 4| 7| 6| 6| 5| 6| 4| 6| 5| 5| 6| 5| 6| 7| 5| 4| 5| 5| 6|
DAY ON TEST | 8| 0| 3| 8| 5| 2| 8| 3| 8| 4| 9| 5| 5| 3| 1| 4| 4| 9| 5| 3| 1| 5| 4| 7| 3|
| 2| 3| 7| 9| 6| 4| 4| 0| 5| 3| 5| 3| 6| 7| 2| 5| 3| 5| 0| 0| 0| 6| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | 1 |
Acinar Cell, Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 |
Erosion | |
Fibrosis | 2 |
Ulcer | 3 4 |
Mucosa, Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 2 |
Erosion | 1 2 |
Mineralization | 3 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 1 3 2 1 2 3 2 2 2 2 1|
Thrombosis | X |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Hyperplasia, Focal | 2 1 |
Hypertrophy, Focal | |
Pigmentation | |
Vacuolization Cytoplasmic, Diffuse | 2 2 2 |
Vacuolization Cytoplasmic, Focal | 1 1 1 1 1 3 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 3 3 1 2 3 3 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 2 3 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 1 1 3 1 |
Pars Intermedia, Cyst | X |
Pars Nervosa, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 4| 6| 4| 7| 6| 6| 5| 6| 4| 6| 5| 5| 6| 5| 6| 7| 5| 4| 5| 5| 6|
DAY ON TEST | 8| 0| 3| 8| 5| 2| 8| 3| 8| 4| 9| 5| 5| 3| 1| 4| 4| 9| 5| 3| 1| 5| 4| 7| 3|
| 2| 3| 7| 9| 6| 4| 4| 0| 5| 3| 5| 3| 6| 7| 2| 5| 3| 5| 0| 0| 0| 6| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X X X X X X |
Hypospermia | X X X X X X X X X X X |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 2 2 2 |
Ectasia | |
Fibrosis | 4 |
Hyperplasia, Lymphoid | 1 1 2 3 1|
Inflammation, Suppurative | 2 3 1 1 3 2 3 2 2 2 2 3 2 3 4 2 2 2 2|
Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Interstitial Cell, Hyperplasia | 3 2 1 1 1 |
Seminiferous Tubule, Atrophy | 3 3 2 1 4 1 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 2 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Necrosis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Ectasia | 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 4| 6| 4| 7| 6| 6| 5| 6| 4| 6| 5| 5| 6| 5| 6| 7| 5| 4| 5| 5| 6|
DAY ON TEST | 8| 0| 3| 8| 5| 2| 8| 3| 8| 4| 9| 5| 5| 3| 1| 4| 4| 9| 5| 3| 1| 5| 4| 7| 3|
| 2| 3| 7| 9| 6| 4| 4| 0| 5| 3| 5| 3| 6| 7| 2| 5| 3| 5| 0| 0| 0| 6| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 2 2 3 |
Hyperplasia, Plasma Cell | 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 2 2 3 3 2 3 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2|
Necrosis | |
Pigmentation | 3 2 2 2 2 3 2 2 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M M + + + + + + + + + M + + + + + + +|
Hyperplasia, Cystic | 3 3 1 1 2 4 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Cyst Epithelial Inclusion | X |
Exudate | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 1 2 3 2 2 2 2 1 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X|
Granuloma | 2 |
Hemorrhage | 2 |
Hydrocephalus | 2 2 2 2|
Vacuolization Cytoplasmic | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 3 |
Infiltration Cellular, Histiocyte | 1 1 1 |
Inflammation, Subacute | 3 1 1 2 1 1 |
Leukocytosis | |
Metaplasia, Osseous | 1 |
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 4| 6| 4| 7| 6| 6| 5| 6| 4| 6| 5| 5| 6| 5| 6| 7| 5| 4| 5| 5| 6|
DAY ON TEST | 8| 0| 3| 8| 5| 2| 8| 3| 8| 4| 9| 5| 5| 3| 1| 4| 4| 9| 5| 3| 1| 5| 4| 7| 3|
| 2| 3| 7| 9| 6| 4| 4| 0| 5| 3| 5| 3| 6| 7| 2| 5| 3| 5| 0| 0| 0| 6| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 2 2 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X X X X |
Foreign Body | 2 2 2 2 1 2 2 |
Fungus | X X X X X X X X X |
Mucosa, Hyperplasia | 2 2 2 3 3 2 2 3 3 2 2 2 |
Mucosa, Metaplasia, Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 2 1|
Mineralization | 1 1 1 1 1 1 2 1 2 3 1 1 1 2 |
Nephropathy | 3 4 4 4 3 4 2 3 4 4 4 4 3 3 4 2 2 3 3 4 3 2 2 4 3|
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Hyperplasia | 2 2 2 2 |
Renal Tubule, Hyperplasia, Oncocytic | 2 |
Renal Tubule, Pigmentation | 3 2 |
Transitional Epithelium, Hyperplasia | 1 2 2 1 2 1 2 3 3 2 3 2 3 3 2 2 2 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Dilatation | 3 |
Inflammation, Subacute | 2 |
Mucosa, Hyperplasia | 3 1|
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 6| 4| 4| 6| 6| | |
DAY ON TEST | 3| 3| 5| 5| 7| 3| 5| 4| 6| 7| | |
| 0| 0| 6| 1| 3| 8| 6| 9| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + M + + + | 55 |
Ectopic Tissue | | 1 |
Erosion | 2 | 8 1.9|
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Mucosa, Hyperplasia, Diffuse | 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 1 2 | 6 1.8|
Basophilic Focus | X X X | 24 |
Clear Cell Focus | X | 3 |
Congestion | 3 | 2 2.5|
Degeneration, Cystic | 1 | 8 1.9|
Granuloma | | 6 1.2|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 6 |
Hyperplasia, Focal | 2 | 4 1.8|
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Subacute | | 4 1.3|
Mixed Cell Focus | X | 3 |
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | 3 1 2 2 2 2 4 1 | 47 1.6|
Centrilobular, Atrophy | 3 2 2 | 7 2.4|
Centrilobular, Necrosis | | 2 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 13 2.4|
Kupffer Cell, Pigmentation | | 4 1.8|
Lobules, Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | | 9 |
Accessory Spleen | | 1 |
Fat, Necrosis | | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | 1 1 1 1 2 1 | 33 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 6| 4| 4| 6| 6| | |
DAY ON TEST | 3| 3| 5| 5| 7| 3| 5| 4| 6| 7| | |
| 0| 0| 6| 1| 3| 8| 6| 9| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Focal Cellular Change | | 1 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
Acinar Cell, Cytoplasmic Alteration | 3 3 | 13 2.8|
Acinar Cell, Hyperplasia, Focal | 1 | 7 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | | 2 1.0|
Acinar Cell, Cytoplasmic Alteration | 3 | 4 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | 3 3 | 4 3.0|
Erosion | 1 | 1 1.0|
Fibrosis | | 1 2.0|
Ulcer | 4 3 4 | 9 3.7|
Mucosa, Hyperplasia | 1 2 3 3 | 10 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | 3 3 | 5 2.4|
Erosion | | 6 2.2|
Mineralization | 3 | 2 3.0|
Ulcer | 2 | 7 2.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 1 3 | 29 1.7|
Thrombosis | | 1 |
Myocardium, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X X | 15 |
Hyperplasia, Focal | 3 | 7 1.9|
Hypertrophy, Focal | | 2 1.5|
Pigmentation | | 1 3.0|
Vacuolization Cytoplasmic, Diffuse | 3 | 4 2.3|
Vacuolization Cytoplasmic, Focal | 3 1 3 1 | 17 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 2 2 1 2 | 23 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 6| 4| 4| 6| 6| | |
DAY ON TEST | 3| 3| 5| 5| 7| 3| 5| 4| 6| 7| | |
| 0| 0| 6| 1| 3| 8| 6| 9| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 59 |
Hyperplasia | 3 2 3 | 13 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Angiectasis | 3 3 2 | 3 2.7|
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 2 | 9 1.6|
Pars Intermedia, Cyst | | 1 |
Pars Nervosa, Hyperplasia | | 4 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | | 1 1.0|
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | | 2 1.0|
Follicle, Cyst | | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atypia Cellular | | 11 |
Hypospermia | X X | 19 |
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Ectasia | | 1 3.0|
Inflammation, Chronic | 2 2 2 2 | 23 2.0|
Inflammation, Suppurative | | 5 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Corpora Amylacea | 2 3 3 | 9 2.2|
Ectasia | 3 | 1 3.0|
Fibrosis | 3 2 | 3 3.0|
Hyperplasia, Lymphoid | 2 2 | 9 1.6|
Inflammation, Suppurative | 2 3 3 4 2 3 2 3 2 3 | 46 2.4|
Epithelium, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Fibrosis | 3 | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 6| 4| 4| 6| 6| | |
DAY ON TEST | 3| 3| 5| 5| 7| 3| 5| 4| 6| 7| | |
| 0| 0| 6| 1| 3| 8| 6| 9| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 2 2 | 11 1.5|
Seminiferous Tubule, Atrophy | | 10 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 4 2.3|
Myelofibrosis | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 15 |
Mediastinal, Hemorrhage | 2 | 3 2.7|
Mediastinal, Hyperplasia, Plasma Cell| 2 | 1 2.0|
Mediastinal, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Congestion | | 1 3.0|
Ectasia | 3 | 4 2.3|
Hemorrhage | 1 | 2 1.0|
Hyperplasia, Lymphoid | 2 | 8 2.4|
Hyperplasia, Plasma Cell | 2 4 4 | 11 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Ectasia | | 2 2.5|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 6 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 |
Fibrosis | 3 3 3 | 14 2.6|
Hematopoietic Cell Proliferation | 2 2 | 12 2.2|
Necrosis | 3 | 1 3.0|
Pigmentation | 2 | 23 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 57 |
Hyperplasia, Cystic | 2 1 2 1 2 2 | 27 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Acanthosis | | 2 1.5|
Cyst Epithelial Inclusion | | 1 |
Exudate | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 6| 4| 4| 6| 6| | |
DAY ON TEST | 3| 3| 5| 5| 7| 3| 5| 4| 6| 7| | |
| 0| 0| 6| 1| 3| 8| 6| 9| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Fibrous Osteodystrophy | 3 2 1 | 16 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X X | 19 |
Granuloma | | 1 2.0|
Hemorrhage | | 1 2.0|
Hydrocephalus | 2 2 | 12 2.1|
Vacuolization Cytoplasmic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 4 2.5|
Hemorrhage | 1 3 | 2 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
Infiltration Cellular, Histiocyte | 1 1 2 2 1 3 | 12 1.4|
Inflammation, Subacute | 1 | 7 1.4|
Leukocytosis | | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 6 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X X X X X X X | 34 |
Foreign Body | 2 2 1 2 1 | 18 1.9|
Fungus | X X X | 22 |
Mucosa, Hyperplasia | 3 2 2 | 24 2.5|
Mucosa, Metaplasia, Squamous | 2 2 | 9 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 1 1 | 12 1.2|
Mineralization | 2 1 2 1 1 1 2 1 1 1 | 40 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 6| 4| 4| 6| 6| | |
DAY ON TEST | 3| 3| 5| 5| 7| 3| 5| 4| 6| 7| | |
| 0| 0| 6| 1| 3| 8| 6| 9| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.25% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 3 3 3 4 4 2 3 2 3 4 | 60 3.1|
Renal Tubule, Cytoplasmic Alteration | | 1 3.0|
Renal Tubule, Hyperplasia | 2 2 | 6 2.0|
Renal Tubule, Hyperplasia, Oncocytic | | 2 1.5|
Renal Tubule, Pigmentation | 2 | 6 2.7|
Transitional Epithelium, Hyperplasia | 1 1 3 3 1 2 3 | 36 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Dilatation | 3 | 2 3.0|
Inflammation, Subacute | | 1 2.0|
Mucosa, Hyperplasia | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 4| 5| 5| 6| 5| 7| 6| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 5| 6| 6|
DAY ON TEST | 7| 5| 9| 2| 2| 5| 2| 7| 5| 2| 5| 7| 7| 5| 8| 8| 9| 0| 5| 7| 6| 9| 9| 0| 6|
| 7| 6| 5| 6| 4| 5| 9| 2| 6| 4| 3| 5| 5| 6| 8| 7| 4| 8| 6| 9| 7| 4| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.50% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Edema | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mucosa, Hyperplasia, Diffuse | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 1 |
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X |
Congestion | |
Degeneration, Cystic | 3 2 |
Eosinophilic Focus | X X |
Granuloma | 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 1 2|
Inflammation, Subacute | 2 1 |
Mixed Cell Focus | X X |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 1 1 1 1 4 2 3 1 2 1 4 2 1 1 3 3 2 3 2 1 1 1 1 3|
Centrilobular, Atrophy | 3 2 2 2 2|
Centrilobular, Necrosis | 2|
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Pigmentation | 2 2 |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | |
Accessory Spleen | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 3 1 2 2 1 3 2 2 1|
Cyst | X X |
Acinar Cell, Cytoplasmic Alteration | 3 3 3 |
Acinar Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 118
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 4| 5| 5| 6| 5| 7| 6| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 5| 6| 6|
DAY ON TEST | 7| 5| 9| 2| 2| 5| 2| 7| 5| 2| 5| 7| 7| 5| 8| 8| 9| 0| 5| 7| 6| 9| 9| 0| 6|
| 7| 6| 5| 6| 4| 5| 9| 2| 6| 4| 3| 5| 5| 6| 8| 7| 4| 8| 6| 9| 7| 4| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.50% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Acinar Cell, Cytoplasmic Alteration | 3 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Inflammation, Subacute | |
Ulcer | 3 2 |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 1 2 |
Mineralization | 1 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Hypertrophy | |
Inflammation, Chronic Active | |
Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 1 1 2 2 3 1 2|
Thrombosis | X X |
Myocardium, Inflammation, Chronic | 1 |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Basophilic Focus | X |
Hyperplasia, Focal | 1 |
Necrosis | |
Pigmentation | 2 2 |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 3 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + I + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 119
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 4| 5| 5| 6| 5| 7| 6| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 5| 6| 6|
DAY ON TEST | 7| 5| 9| 2| 2| 5| 2| 7| 5| 2| 5| 7| 7| 5| 8| 8| 9| 0| 5| 7| 6| 9| 9| 0| 6|
| 7| 6| 5| 6| 4| 5| 9| 2| 6| 4| 3| 5| 5| 6| 8| 7| 4| 8| 6| 9| 7| 4| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.50% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pigmentation | |
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Hyperplasia | 2 3 3 1 2 2|
Pars Intermedia, Cyst | X X|
Pars Nervosa, Hyperplasia | 1 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 |
Hypoplasia | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 2|
Follicle, Cyst | X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X X X X X |
Hypospermia | X X X X X X X X X|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 2 2 3 2 2 2 2 2 2 3 2|
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 3 3 3 3 |
Ectasia | |
Fibrosis | 2 |
Hyperplasia, Lymphoid | 2 2 2 1 |
Inflammation, Suppurative | 1 2 2 2 2 1 3 2 3 3 1 2 3 2 2|
Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1 1 2 2 1 2 2 1 1 1|
Seminiferous Tubule, Atrophy | 2 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Inguinal, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 120
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 4| 5| 5| 6| 5| 7| 6| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 5| 6| 6|
DAY ON TEST | 7| 5| 9| 2| 2| 5| 2| 7| 5| 2| 5| 7| 7| 5| 8| 8| 9| 0| 5| 7| 6| 9| 9| 0| 6|
| 7| 6| 5| 6| 4| 5| 9| 2| 6| 4| 3| 5| 5| 6| 8| 7| 4| 8| 6| 9| 7| 4| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.50% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Hemorrhage | 3 |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 2 |
Fibrosis | 3|
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | 3 2 2 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 2 2 2 2|
Hematopoietic Cell Proliferation | 2 2 2 2 1 |
Necrosis | 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + M + + + + + + + + + + +|
Cyst | X X |
Ectopic Parathyroid Gland | |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + M M + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 1 1 |
Hyperostosis | 3 |
Necrosis | 3 |
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | |
Hydrocephalus | 2 |
Mineralization | 2 |
Necrosis | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 121
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 5| 4| 5| 5| 6| 5| 7| 6| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 5| 6| 6|
DAY ON TEST | 7| 5| 9| 2| 2| 5| 2| 7| 5| 2| 5| 7| 7| 5| 8| 8| 9| 0| 5| 7| 6| 9| 9| 0| 6|
| 7| 6| 5| 6| 4| 5| 9| 2| 6| 4| 3| 5| 5| 6| 8| 7| 4| 8| 6| 9| 7| 4| 4| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.50% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | 2 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 3 1 1 2|
Inflammation, Subacute | |
Inflammation, Suppurative | 2 |
Alveolar Epithelium, Hyperplasia | 1 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X X X|
Foreign Body | 3 2 1 1 |
Fungus | X X X X X X X X|
Mucosa, Hyperplasia | 3 2 3 2 2 2 3 2 3 2|
Mucosa, Metaplasia, Squamous | 2 2 3 2 2|
Mucosa, Necrosis | 3 4 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + +|
Cataract | 3 3|
Retina, Atrophy | 3 4|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 2 |
Hydronephrosis | 2 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | 1 1 2 1 1 2 1 |
Mineralization | 1 1 3 2 2 2 3 2 3 1 2 3 1 2 3 1 3 2 2 2 3 3 1 3|
Nephropathy | 3 3 4 3 3 3 3 4 2 4 4 3 4 3 3 2 4 3 3 4 3 4 4 4 4|
Thrombosis | X |
Interstitial Tissue, Pigmentation | |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | 3 3 3 2 |
Transitional Epithelium, Hyperplasia | 2 2 1 1 1 3 3 2 2 1 2 3 2 2 2 3 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 122
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 2| 5| 5| 6| 6| 4| 6| 2| 5| 4| 5| 6| 6| 6| 5| 6| 4| 5| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 5| 6| 9| 0| 0| 5| 5| 6| 7| 9| 5| 9| 5| 7| 7| 6| 0| 5| 8| 6| 3| 4| 7| 5| 5|
| 6| 2| 8| 6| 4| 3| 6| 6| 4| 4| 6| 8| 0| 9| 9| 2| 4| 6| 3| 9| 6| 6| 2| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.50% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Edema | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Mucosa, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X |
Clear Cell Focus | X X X X |
Congestion | 2 |
Degeneration, Cystic | 1 2 |
Eosinophilic Focus | X |
Granuloma | 1 |
Hematopoietic Cell Proliferation | 2 3 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | 2 |
Inflammation, Subacute | 1 1 |
Mixed Cell Focus | X |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 2 3 1 3 1 2 1 2 1 1 1 2 1 2 1 3 1 2 2 2 4 |
Centrilobular, Atrophy | 3 2 2 3 2 2 2 2|
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 1 2 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | |
Accessory Spleen | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 1 1 2 1 |
Cyst | X |
Acinar Cell, Cytoplasmic Alteration | 3 2 4 2 |
Acinar Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 123
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 2| 5| 5| 6| 6| 4| 6| 2| 5| 4| 5| 6| 6| 6| 5| 6| 4| 5| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 5| 6| 9| 0| 0| 5| 5| 6| 7| 9| 5| 9| 5| 7| 7| 6| 0| 5| 8| 6| 3| 4| 7| 5| 5|
| 6| 2| 8| 6| 4| 3| 6| 6| 4| 4| 6| 8| 0| 9| 9| 2| 4| 6| 3| 9| 6| 6| 2| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.50% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Acinar Cell, Cytoplasmic Alteration | 3 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Erosion | 1 |
Inflammation, Subacute | |
Ulcer | 2 |
Mucosa, Hyperplasia | 2 1 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 2 |
Erosion | 2 1 2 |
Mineralization | 2 |
Ulcer | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Hypertrophy | 4 |
Inflammation, Chronic Active | 3 |
Thrombosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 3 1 1 1 1 2 1 2 1 2 1 3 2|
Thrombosis | |
Myocardium, Inflammation, Chronic | |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X |
Basophilic Focus | |
Hyperplasia, Focal | 2 2 1 |
Necrosis | |
Pigmentation | |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | 1 1 1 2 2 3 2 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 124
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 2| 5| 5| 6| 6| 4| 6| 2| 5| 4| 5| 6| 6| 6| 5| 6| 4| 5| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 5| 6| 9| 0| 0| 5| 5| 6| 7| 9| 5| 9| 5| 7| 7| 6| 0| 5| 8| 6| 3| 4| 7| 5| 5|
| 6| 2| 8| 6| 4| 3| 6| 6| 4| 4| 6| 8| 0| 9| 9| 2| 4| 6| 3| 9| 6| 6| 2| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.50% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pigmentation | 2 2 |
Pars Distalis, Angiectasis | 1 2 |
Pars Distalis, Hyperplasia | 2 1 1 1 2 2 |
Pars Intermedia, Cyst | X |
Pars Nervosa, Hyperplasia | 2 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
Hypoplasia | 4 |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X |
Hypospermia | X X X X X X X X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 2 2 2 2 2 2 |
Inflammation, Suppurative | 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 2 2 |
Ectasia | 2 |
Fibrosis | |
Hyperplasia, Lymphoid | 2 2 |
Inflammation, Suppurative | 2 1 2 2 3 1 3 3 3 1 2 2 2 2 3 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 2 2 4 4 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
Myelofibrosis | 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Inguinal, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 125
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 2| 5| 5| 6| 6| 4| 6| 2| 5| 4| 5| 6| 6| 6| 5| 6| 4| 5| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 5| 6| 9| 0| 0| 5| 5| 6| 7| 9| 5| 9| 5| 7| 7| 6| 0| 5| 8| 6| 3| 4| 7| 5| 5|
| 6| 2| 8| 6| 4| 3| 6| 6| 4| 4| 6| 8| 0| 9| 9| 2| 4| 6| 3| 9| 6| 6| 2| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.50% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 2 |
Fibrosis | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 2 4 3 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Mast Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 1 3 1 3 4 |
Hematopoietic Cell Proliferation | 3 2 2 2 2 3 |
Necrosis | |
Pigmentation | 2 2 2 2 3 2 2 2 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + I + + + + + + + + + + + + + + +|
Cyst | X |
Ectopic Parathyroid Gland | X |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Cystic | 1 3 2 3 3 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 3 2 2 |
Hyperostosis | |
Necrosis | |
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hemorrhage | |
Hydrocephalus | 2 2 2 |
Mineralization | |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 126
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
_____________________________________________________________________________________________________________________
| 4| 2| 5| 5| 6| 6| 4| 6| 2| 5| 4| 5| 6| 6| 6| 5| 6| 4| 5| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 5| 6| 9| 0| 0| 5| 5| 6| 7| 9| 5| 9| 5| 7| 7| 6| 0| 5| 8| 6| 3| 4| 7| 5| 5|
| 6| 2| 8| 6| 4| 3| 6| 6| 4| 4| 6| 8| 0| 9| 9| 2| 4| 6| 3| 9| 6| 6| 2| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.50% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 3 |
Inflammation, Subacute | 2 1 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X |
Foreign Body | 2 2 2 2 1 2 |
Fungus | X X X X |
Mucosa, Hyperplasia | 2 2 3 2 1 3 1 |
Mucosa, Metaplasia, Squamous | 3 |
Mucosa, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | |
Hydronephrosis | |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 1 1 |
Mineralization | 2 2 3 3 2 3 3 2 2 2 3 3 3 3 3 1 2 3 2 3 1 3 2 2|
Nephropathy | 2 2 4 3 3 3 3 4 2 4 3 3 3 4 4 3 3 2 2 3 3 3 3 3 2|
Thrombosis | |
Interstitial Tissue, Pigmentation | |
Renal Tubule, Hyperplasia | 2 2 2 2 1 |
Renal Tubule, Pigmentation | 2 3 3 3 2 |
Transitional Epithelium, Hyperplasia | 2 1 2 2 3 1 2 3 2 2 3 1 2 1 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 127
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 5| 4| 5| 5| 4| 7| 6| | |
DAY ON TEST | 6| 8| 3| 6| 5| 9| 7| 5| 0| 0| | |
| 6| 9| 9| 9| 6| 6| 5| 6| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.50% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Dilatation | | 1 4.0|
Edema | | 1 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Erosion | 1 1 2 | 4 1.3|
Mucosa, Hyperplasia, Diffuse | 2 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Mucosa, Hyperplasia, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 4 2.0|
Basophilic Focus | X X X | 18 |
Clear Cell Focus | | 5 |
Congestion | | 1 2.0|
Degeneration, Cystic | 3 1 | 6 2.0|
Eosinophilic Focus | | 3 |
Granuloma | | 2 1.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Hepatodiaphragmatic Nodule | | 3 |
Hyperplasia, Focal | 2 4 2 | 6 2.2|
Inflammation, Subacute | | 4 1.3|
Mixed Cell Focus | | 3 |
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | 3 3 1 1 1 3 1 1 2 | 55 1.8|
Centrilobular, Atrophy | 2 2 2 | 16 2.2|
Centrilobular, Necrosis | 2 | 2 2.0|
Hepatocyte, Vacuolization Cytoplasmic| | 4 2.0|
Kupffer Cell, Pigmentation | | 2 2.0|
Lobules, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 3 |
Accessory Spleen | X | 1 |
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 128
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 5| 4| 5| 5| 4| 7| 6| | |
DAY ON TEST | 6| 8| 3| 6| 5| 9| 7| 5| 0| 0| | |
| 6| 9| 9| 9| 6| 6| 5| 6| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.50% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | 1 3 2 1 2 1 3 | 25 1.7|
Cyst | | 3 |
Acinar Cell, Cytoplasmic Alteration | 2 2 2 2 | 11 2.5|
Acinar Cell, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | 1 | 2 1.5|
Acinar Cell, Cytoplasmic Alteration | | 4 3.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 2 2.0|
Erosion | 2 | 2 1.5|
Inflammation, Subacute | 1 | 1 1.0|
Ulcer | | 3 2.3|
Mucosa, Hyperplasia | 1 2 | 7 1.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 3 2.0|
Erosion | 2 | 6 1.7|
Mineralization | | 2 1.5|
Ulcer | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Hypertrophy | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 2 3 | 28 1.6|
Thrombosis | | 2 |
Myocardium, Inflammation, Chronic | | 1 1.0|
Myocardium, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X X X X | 14 |
Basophilic Focus | | 1 |
Hyperplasia, Focal | | 4 1.5|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 129
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 5| 4| 5| 5| 4| 7| 6| | |
DAY ON TEST | 6| 8| 3| 6| 5| 9| 7| 5| 0| 0| | |
| 6| 9| 9| 9| 6| 6| 5| 6| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.50% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pigmentation | | 2 2.0|
Vacuolization Cytoplasmic, Diffuse | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 2 1 1 | 15 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 3 1 | 15 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 58 |
Hyperplasia | 2 | 6 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pigmentation | | 2 2.0|
Pars Distalis, Angiectasis | | 4 2.0|
Pars Distalis, Hyperplasia | 2 | 13 1.8|
Pars Intermedia, Cyst | | 3 |
Pars Nervosa, Hyperplasia | 1 1 1 | 11 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | | 3 1.0|
Hypoplasia | | 1 4.0|
Ultimobranchial Cyst | X | 2 |
C-Cell, Hyperplasia | | 3 1.3|
Follicle, Cyst | X | 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atypia Cellular | X X X | 10 |
Hypospermia | X X X X X | 23 |
__________________________________________________________________________|____________|
Preputial Gland | M + + + + + + + + + | 59 |
Inflammation, Chronic | 2 3 3 2 2 2 | 27 2.1|
Inflammation, Suppurative | 3 2 3 | 6 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Corpora Amylacea | | 7 2.6|
Ectasia | | 1 2.0|
Fibrosis | 2 2 | 3 2.0|
Hyperplasia, Lymphoid | 1 1 | 8 1.6|
Inflammation, Suppurative | 3 3 1 2 2 3 | 37 2.1|
Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 130
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 5| 4| 5| 5| 4| 7| 6| | |
DAY ON TEST | 6| 8| 3| 6| 5| 9| 7| 5| 0| 0| | |
| 6| 9| 9| 9| 6| 6| 5| 6| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.50% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Depletion Cellular | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 1 1 | 20 1.3|
Seminiferous Tubule, Atrophy | 1 4 3 3 | 13 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | 2 | 2 2.5|
Myelofibrosis | 2 | 4 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 20 |
Inguinal, Hyperplasia, Plasma Cell | | 1 3.0|
Mediastinal, Hemorrhage | 2 | 2 2.5|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Hemorrhage | | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Ectasia | 2 | 7 1.9|
Fibrosis | | 1 3.0|
Hyperplasia, Lymphoid | | 3 2.0|
Hyperplasia, Plasma Cell | | 11 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hemorrhage | | 5 1.8|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Mast Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 3 3 | 14 2.4|
Hematopoietic Cell Proliferation | 3 | 12 2.2|
Necrosis | | 1 2.0|
Pigmentation | 2 3 2 | 25 2.1|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + | 56 |
Cyst | | 3 |
Ectopic Parathyroid Gland | | 1 |
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 56 |
Hyperplasia, Cystic | 3 2 2 2 | 16 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 131
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 5| 4| 5| 5| 4| 7| 6| | |
DAY ON TEST | 6| 8| 3| 6| 5| 9| 7| 5| 0| 0| | |
| 6| 9| 9| 9| 6| 6| 5| 6| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.50% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | 1 1 | 10 1.5|
Hyperostosis | | 1 3.0|
Necrosis | | 1 3.0|
Femur, Osteopetrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 6 |
Hemorrhage | 2 2 | 2 2.0|
Hydrocephalus | 2 | 5 2.0|
Mineralization | 2 | 2 2.0|
Necrosis | | 3 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Foreign Body | | 1 2.0|
Hemorrhage | | 2 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 | 15 1.3|
Inflammation, Subacute | | 2 1.5|
Inflammation, Suppurative | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 | 5 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | X X X X | 24 |
Foreign Body | 2 3 | 12 1.9|
Fungus | X X | 14 |
Mucosa, Hyperplasia | 3 2 1 2 | 21 2.2|
Mucosa, Metaplasia, Squamous | 2 | 7 2.3|
Mucosa, Necrosis | 1 | 4 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 3 3.0|
Retina, Atrophy | | 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 132
NTP Experiment-Test: 05142-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TERT-BUTYL ALCOHOL Date: 04/23/97
Route: DOSED WATER Time: 14:52:32
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 5| 4| 5| 5| 4| 7| 6| | |
DAY ON TEST | 6| 8| 3| 6| 5| 9| 7| 5| 0| 0| | |
| 6| 9| 9| 9| 6| 6| 5| 6| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.50% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | X | 1 |
Hemorrhage | | 1 2.0|
Hydronephrosis | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Suppurative | | 9 1.2|
Mineralization | 3 2 1 2 2 2 3 1 3 | 57 2.2|
Nephropathy | 3 3 3 3 2 4 3 3 4 3 | 60 3.2|
Thrombosis | | 1 |
Interstitial Tissue, Pigmentation | 2 | 1 2.0|
Renal Tubule, Hyperplasia | | 6 1.7|
Renal Tubule, Pigmentation | 2 3 2 | 12 2.6|
Transitional Epithelium, Hyperplasia | 2 2 2 3 2 2 3 | 40 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | 3 | 2 3.0|
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 133
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