TDMS Study 05142-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst T-BUTYL ALCOHOL DATE: 05/20/95
EXPERIMENT: 05142 TEST: 03 TIME: 07:57:41
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55121 ROUTE: DOSED WATER NTP C#: 55367B
PATHOLOGIST: DR J. HEATH S. EUSTIS CAS: 75-65-0
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst T-BUTYL ALCOHOL DATE: 05/20/95
EXPERIMENT: 05142 TEST: 03 TIME: 07:57:41
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55121 ROUTE: DOSED WATER NTP C#: 55367B
PATHOLOGIST: DR J. HEATH S. EUSTIS CAS: 75-65-0
T-BUTYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 40 CENSORED DEATHS 10 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 20 288 505 526 526 553 553 553 553 562 |
| 563 572 573 586 588 589 594 594 595 603 |
| 604 614 617 617 622 623 630 636 637 645 |
| 646 657 669 672 678 692 694 698 720 720 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.125% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 44 CENSORED DEATHS 10 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 307 348 395 512 520 553 557 562 569 575 |
| 575 575 584 591 596 602 603 603 605 619 |
| 624 624 626 629 630 639 646 651 651 656 |
| 666 666 672 673 679 679 692 693 694 699 |
| 708 708 720 720 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 46 CENSORED DEATHS 10 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 343 355 398 449 484 510 512 525 528 542 |
| 545 547 551 553 556 569 577 580 582 589 |
| 589 595 595 603 605 607 623 624 630 637 |
| 637 637 638 643 643 645 650 651 653 666 |
| 673 673 678 679 685 703 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
T-BUTYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.50% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 49 CENSORED DEATHS 10 TERMINAL 1 |
| |
| UNCENSORED DEATHS |
| 262 274 506 508 526 553 555 555 562 566 |
| 569 569 575 575 575 577 583 587 588 589 |
| 594 594 594 594 595 596 598 598 604 604 |
| 604 604 624 624 636 639 646 650 651 653 |
| 666 667 669 672 672 679 679 679 708 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
T-BUTYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 98.3 98.3 98.3 96.7 96.7 96.7 90.6 58.4 36.3 20.1 |
|CONTROL | |
| | |
|0.125% | 100.0 100.0 100.0 96.7 95.0 95.0 91.0 62.7 40.4 12.1 |
| | |
| | |
|0.25% | 100.0 100.0 100.0 96.7 95.0 91.3 79.1 50.7 22.3 8.1 |
| | |
| | |
|0.50% | 100.0 100.0 98.3 96.7 96.7 96.7 90.6 36.3 20.1 2.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 0.125% 0.25% 0.50% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 20.1% 12.1% 8.1% 2.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.001 P=0.853 P=0.091 P=0.010 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 589.7 611.3 586.0 592.8 |
|NATURAL DEATHS (C) | (18.7) (13.5) (12.1) (11.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 590.6 597.2 573.9 572.3 |
|(STANDARD ERROR) | (16.1) (13.6) (12.4) (11.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
T-BUTYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 226 428 524 547 554 576 580 589 591 594 |
| 603 604 625 627 637 645 646 650 674 680 |
| 695 723 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 26 CENSORED DEATHS 10 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 232 324 424 430 502 533 542 552 552 589 |
| 590 591 593 610 611 612 618 624 625 645 |
| 646 674 703 703 723 727 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.50% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 28 CENSORED DEATHS 10 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 255 321 332 377 384 459 468 534 562 563 |
| 565 573 575 598 637 639 645 651 652 667 |
| 694 694 699 701 703 703 708 724 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
T-BUTYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.00% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 38 CENSORED DEATHS 10 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 206 476 511 551 555 576 590 591 591 597 |
| 597 597 605 610 610 610 617 617 624 624 |
| 625 625 625 631 636 643 666 666 667 674 |
| 685 685 693 703 703 703 708 727 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
T-BUTYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 98.3 98.3 98.3 96.7 94.7 76.5 64.4 56.4 |
|CONTROL | |
| | |
|0.25% | 100.0 100.0 98.3 96.7 95.0 93.3 87.2 75.1 58.8 48.7 |
| | |
| | |
|0.50% | 100.0 100.0 98.3 95.0 91.7 87.6 85.6 73.3 63.1 44.8 |
| | |
| | |
|1.00% | 100.0 100.0 98.3 98.3 98.3 96.3 94.3 74.3 48.2 24.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 0.25% 0.50% 1.00% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.4% 48.7% 44.8% 24.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.004 P=0.476 P=0.335 P=0.006 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 591.7 576.0 574.4 616.3 |
|NATURAL DEATHS (C) | (22.1) (23.0) (25.6) (14.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 633.3 617.4 611.5 612.3 |
|(STANDARD ERROR) | (15.3) (16.3) (17.4) (13.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
T-BUTYL ALCOHOL
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
0.125% = 2
0.25% = 3
0.50% = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 4 2 3
| 1 4 4 1 2 323 2 1
| 2 3 12 1
| 3 3 32 24
90 + 33 21 12
| 3 3 422
| 33 422
| 3 31 122
80 + 33 44
| 1122
| 1 1 2
| 33 22
P 70 + 3 331 1
E | 44 22
R | 33
C | 3 1 1 2
E 60 + 22
N | 111
T | 3 3
|
S 50 + 44 2 2
U | 3 11122
R | 44
V | 31 12
I 40 + 2 2
V | 4 43311 1
A | 22
L | 44 11
30 + 433 1 1
| 44 2 11
| 33 21 1
| 43 3
20 + 4 33 2 21 1
|
| 22
| 33 2 2
10 + 443 3
| 3 3
| 4 4
| 4 4
0 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 39 obs hidden.
T-BUTYL ALCOHOL
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
0.25% = 2
0.50% = 3
1.00% = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 12 3
| 4 12 3 323 21 4 4 1
| 3 3 22 4 1 1
| 3 3 2 3 2 2 11
90 + 33 22 1 1
| 3 322 1 1
| 3 3
| 2 24
P 80 + 33 1 1
E | 33 41 1
R | 3 2342
C | 3 113
E 70 + 22 131
N | 422
T | 44 13 1
| 2 23 311
S 60 + 2 321 1
U | 2 12 1 1
R | 44 33
V | 2 2
I 50 + 44 33
V | 4 4 3 2 2
A | 3 3
L | 44
40 + 44
|
| 44 4
|
30 +
| 44
| 4 4 4
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 29 obs hidden.