TDMS Study 05143-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
CORN OIL / CORN OIL
NTP Experiment-Test: 05143-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/17/94
Route: GAVAGE Time: 18:44:16
Facility: TSI Mason Research
Chemical CAS #: 8001-30-7
Lock Date: 11/08/91
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05143-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CORN OIL / CORN OIL Date: 09/17/94
Route: GAVAGE Time: 18:44:16
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 10 2.5 5.0 10.0
ML/KG ML/KG ML/KG ML/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50
Early Deaths
Moribund Sacrifice 16 14 9 6 4
Natural Death 8 4 8 6 6
Survivors
Terminal Sacrifice 25 32 33 38 40
Natural Death 1
Animals Examined Microscopically 50 50 50 50 50
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ALIMENTARY SYSTEM
Esophagus (49) (48) (50) (50) (50)
Hyperkeratosis 1 (2%)
Intestine Large, Colon (49) (49) (46) (49) (48)
Cyst 1 (2%)
Intestine Large, Cecum (46) (49) (45) (48) (46)
Erosion 3 (7%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Ulcer 1 (2%)
Intestine Small, Ileum (46) (49) (45) (48) (47)
Erosion 1 (2%)
Fibrosis 1 (2%)
Pigmentation 1 (2%)
Liver (50) (50) (50) (50) (50)
Angiectasis 2 (4%) 1 (2%)
Basophilic Focus 33 (66%) 33 (66%) 38 (76%) 37 (74%) 46 (92%)
Clear Cell Focus 11 (22%) 16 (32%) 27 (54%) 24 (48%) 21 (42%)
Congestion 1 (2%)
Degeneration, Cystic 2 (4%)
Eosinophilic Focus 9 (18%) 3 (6%) 4 (8%) 4 (8%) 6 (12%)
Fatty Change, Diffuse 3 (6%) 2 (4%) 19 (38%) 27 (54%) 33 (66%)
Fatty Change, Focal 3 (6%) 4 (8%) 3 (6%)
Hematocyst 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 4 (8%) 6 (12%) 4 (8%) 8 (16%) 5 (10%)
Infarct 1 (2%)
Mixed Cell Focus 5 (10%) 5 (10%) 1 (2%) 8 (16%) 8 (16%)
Necrosis 1 (2%) 1 (2%)
Mesentery (6) (7) (8) (4) (8)
Fat, Hemorrhage 1 (13%)
Fat, Inflammation, Chronic Active 1 (17%) 1 (14%)
Fat, Mineralization 2 (25%)
Fat, Necrosis 2 (33%) 3 (43%) 5 (63%) 2 (50%) 7 (88%)
Pancreas (50) (50) (47) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05143-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CORN OIL / CORN OIL Date: 09/17/94
Route: GAVAGE Time: 18:44:16
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 10 2.5 5.0 10.0
ML/KG ML/KG ML/KG ML/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Metaplasia 1 (2%)
Thrombosis 1 (2%)
Acinus, Atrophy 38 (76%) 40 (80%) 25 (53%) 32 (64%) 24 (48%)
Acinus, Hyperplasia 8 (16%) 5 (10%) 28 (60%) 28 (56%) 35 (70%)
Acinus, Hypertrophy, Focal 1 (2%)
Artery, Hyperplasia 1 (2%)
Artery, Inflammation, Chronic Active 2 (4%) 2 (4%) 5 (11%) 1 (2%) 1 (2%)
Pharynx (1) (1)
Hyperkeratosis 1 (100%)
Inflammation, Chronic Active 1 (100%)
Salivary Glands (50) (50) (50) (50) (49)
Inflammation, Chronic Active 1 (2%)
Duct, Metaplasia, Squamous 6 (12%) 6 (12%) 11 (22%) 8 (16%) 8 (16%)
Stomach, Forestomach (50) (49) (50) (50) (50)
Fibrosis 1 (2%)
Hyperkeratosis 3 (6%) 1 (2%) 1 (2%) 2 (4%) 5 (10%)
Hyperplasia, Basal Cell 4 (8%) 4 (8%) 2 (4%) 1 (2%) 8 (16%)
Ulcer 2 (4%) 3 (6%) 1 (2%) 3 (6%)
Stomach, Glandular (50) (50) (50) (50) (48)
Erosion 10 (20%) 4 (8%) 2 (4%) 2 (4%) 2 (4%)
Hyperplasia 3 (6%)
Mineralization 1 (2%) 1 (2%)
Tongue (3) (2) (3)
Hemorrhage 2 (100%)
Hyperplasia, Squamous 1 (33%)
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CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50) (50)
Cardiomyopathy 47 (94%) 42 (84%) 46 (92%) 47 (94%) 45 (90%)
Pigmentation 1 (2%)
Thrombosis 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Hypertrophy 2 (4%) 3 (6%) 4 (8%)
Adrenal Medulla (49) (49) (50) (50) (50)
Cyst 1 (2%)
Hyperplasia 8 (16%) 7 (14%) 12 (24%) 11 (22%) 9 (18%)
Islets, Pancreatic (50) (49) (47) (50) (50)
Hyperplasia 1 (2%) 2 (4%) 4 (9%) 2 (4%) 3 (6%)
Parathyroid Gland (44) (47) (49) (40) (45)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05143-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CORN OIL / CORN OIL Date: 09/17/94
Route: GAVAGE Time: 18:44:16
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 10 2.5 5.0 10.0
ML/KG ML/KG ML/KG ML/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%) 1 (2%) 1 (3%)
Pituitary Gland (50) (49) (50) (49) (50)
Pars Distalis, Angiectasis 5 (10%) 6 (12%) 5 (10%) 4 (8%) 6 (12%)
Pars Distalis, Cyst 1 (2%) 3 (6%) 1 (2%)
Pars Distalis, Hyperplasia 9 (18%) 9 (18%) 13 (26%) 9 (18%) 9 (18%)
Pars Intermedia, Hyperplasia 1 (2%)
Rathke's Cleft, Cyst 1 (2%)
Thyroid Gland (50) (49) (49) (49) (49)
Bilateral, C-Cell, Hyperplasia 1 (2%) 1 (2%)
C-Cell, Hyperplasia 3 (6%) 9 (18%) 8 (16%) 7 (14%) 11 (22%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 3 (6%) 2 (4%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Epididymis (50) (50) (50) (50) (48)
Spermatocele 1 (2%)
Preputial Gland (50) (50) (50) (50) (48)
Abscess 3 (6%) 4 (8%) 4 (8%) 5 (10%) 7 (15%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Prostate (50) (49) (50) (50) (48)
Hyperplasia 2 (4%) 4 (8%) 6 (12%) 7 (14%) 4 (8%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%) 3 (6%)
Testes (50) (50) (50) (50) (49)
Interstitial Cell, Hyperplasia 4 (8%) 3 (6%) 4 (8%) 4 (8%)
Seminiferous Tubule, Atrophy 7 (14%) 4 (8%) 2 (4%) 4 (8%) 6 (12%)
Seminiferous Tubule, Mineralization 1 (2%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50) (50)
Depletion Cellular 1 (2%)
Fibrosis 1 (2%)
Lymph Node (28) (22) (15) (13) (8)
Lumbar, Pigmentation 1 (5%)
Mediastinal, Angiectasis 4 (14%) 1 (5%) 3 (20%) 5 (38%) 1 (13%)
Mediastinal, Ectasia 1 (4%)
Mediastinal, Infiltration Cellular, Mast Cell 1 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05143-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CORN OIL / CORN OIL Date: 09/17/94
Route: GAVAGE Time: 18:44:16
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 10 2.5 5.0 10.0
ML/KG ML/KG ML/KG ML/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Pigmentation 4 (27%) 1 (8%) 2 (25%)
Pancreatic, Angiectasis 1 (4%) 1 (8%)
Pancreatic, Ectasia 3 (11%) 2 (13%)
Pancreatic, Infiltration Cellular, Histiocyte 2 (7%) 2 (25%)
Pancreatic, Pigmentation 1 (7%) 1 (13%)
Renal, Pigmentation 1 (5%)
Lymph Node, Mandibular (50) (50) (49) (50) (48)
Angiectasis 1 (2%)
Necrosis 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (50) (49)
Angiectasis 1 (2%) 1 (2%)
Ectasia 2 (4%) 1 (2%) 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Necrosis 1 (2%)
Spleen (49) (50) (49) (50) (49)
Angiectasis 2 (4%) 1 (2%)
Fibrosis 12 (24%) 8 (16%) 9 (18%) 3 (6%) 4 (8%)
Hematopoietic Cell Proliferation 8 (16%) 6 (12%) 3 (6%) 5 (10%) 5 (10%)
Infarct 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Infiltration Cellular, Lipocyte 1 (2%)
Metaplasia 1 (2%)
Pigmentation 2 (4%) 1 (2%) 1 (2%)
Capsule, Fibrosis 1 (2%)
Capsule, Hemorrhage 1 (2%)
Thymus (48) (48) (45) (45) (46)
Cyst 1 (2%)
Epithelial Cell, Hyperplasia 10 (21%) 7 (15%) 5 (11%) 5 (11%) 9 (20%)
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INTEGUMENTARY SYSTEM
Mammary Gland (31) (42) (39) (39) (40)
Galactocele 2 (5%)
Skin (50) (50) (50) (50) (50)
Cyst Epithelial Inclusion 4 (8%) 2 (4%) 2 (4%)
Developmental Malformation 1 (2%)
Erosion 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Hyperkeratosis 2 (4%)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05143-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CORN OIL / CORN OIL Date: 09/17/94
Route: GAVAGE Time: 18:44:16
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 10 2.5 5.0 10.0
ML/KG ML/KG ML/KG ML/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (50)
Hyperostosis 2 (4%)
Skeletal Muscle (50) (50) (50) (50) (50)
Atrophy 5 (10%) 3 (6%) 8 (16%) 5 (10%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
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NERVOUS SYSTEM
Brain (50) (49) (50) (50) (50)
Compression 1 (2%) 1 (2%)
Spinal Cord (1) (1) (1)
Hemorrhage 1 (100%)
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RESPIRATORY SYSTEM
Lung (49) (49) (50) (49) (49)
Edema 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Foreign Body 1 (2%)
Fungus 1 (2%)
Hemorrhage 2 (4%) 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 5 (10%) 1 (2%) 2 (4%)
Inflammation, Acute 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Nose (50) (50) (50) (49) (49)
Fungus 13 (26%) 12 (24%) 12 (24%) 18 (37%) 15 (31%)
Hyperplasia 1 (2%)
Inflammation, Acute 16 (32%) 14 (28%) 17 (34%) 21 (43%) 21 (43%)
Metaplasia, Cartilagenous 1 (2%)
Respiratory Epithelium, Hyperkeratosis 3 (6%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 7 (14%) 8 (16%) 2 (4%) 7 (14%) 8 (16%)
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SPECIAL SENSES SYSTEM
Eye (1) (3) (2) (3) (2)
Synechia 1 (33%) 1 (33%) 2 (100%)
Lens, Cataract 2 (67%) 2 (67%)
Retina, Atrophy 1 (100%) 1 (33%) 1 (33%) 2 (100%)
Sclera, Mineralization 1 (50%)
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05143-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CORN OIL / CORN OIL Date: 09/17/94
Route: GAVAGE Time: 18:44:16
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ML/KG 10 2.5 5.0 10.0
ML/KG ML/KG ML/KG ML/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (48) (50) (49)
Degeneration 1 (2%)
Hydronephrosis 1 (2%)
Infarct 1 (2%)
Nephropathy 47 (94%) 45 (92%) 43 (90%) 45 (90%) 40 (82%)
Cortex, Mineralization 1 (2%) 2 (4%)
Cortex, Necrosis 1 (2%)
Papilla, Mineralization 2 (4%)
Renal Tubule, Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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